diff --git a/Cargo.lock b/Cargo.lock
index 0d8b97c..fdd2194 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -349,6 +349,15 @@ dependencies = [
  "bitflags 1.2.1",
 ]
 
+[[package]]
+name = "cmake"
+version = "0.1.50"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a31c789563b815f77f4250caee12365734369f942439b7defd71e18a48197130"
+dependencies = [
+ "cc",
+]
+
 [[package]]
 name = "colorchoice"
 version = "1.0.0"
@@ -446,9 +455,9 @@ dependencies = [
 
 [[package]]
 name = "curl-sys"
-version = "0.4.36+curl-7.71.1"
+version = "0.4.63+curl-8.1.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "68cad94adeb0c16558429c3c34a607acc9ea58e09a7b66310aabc9788fc5d721"
+checksum = "aeb0fef7046022a1e2ad67a004978f0e3cacb9e3123dc62ce768f92197b771dc"
 dependencies = [
  "cc",
  "libc",
@@ -465,17 +474,6 @@ version = "0.1.7"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ef8ae57c4978a2acd8b869ce6b9ca1dfe817bff704c220209fdef2c0b75a01b9"
 
-[[package]]
-name = "derefable"
-version = "0.1.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e519abf1289075763071c981958e89948b079fc54962617a0e6413d9ce44cbe7"
-dependencies = [
- "proc-macro2 0.4.30",
- "quote 0.6.13",
- "syn 0.15.44",
-]
-
 [[package]]
 name = "derive-new"
 version = "0.5.8"
@@ -678,9 +676,9 @@ checksum = "443144c8cdadd93ebf52ddb4056d257f5b52c04d3c804e657d19eb73fc33668b"
 
 [[package]]
 name = "hts-sys"
-version = "1.11.1-fix1"
+version = "2.1.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d376f20f3cef2b8e0612c4931dc992f7850882fcfda4dfaa2a0c172f43b3352d"
+checksum = "deebfb779c734d542e7f14c298597914b9b5425e4089aef482eacb5cab941915"
 dependencies = [
  "bzip2-sys",
  "cc",
@@ -824,6 +822,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "602113192b08db8f38796c4e85c39e960c145965140e918018bcde1952429655"
 dependencies = [
  "cc",
+ "cmake",
  "libc",
  "pkg-config",
  "vcpkg",
@@ -1330,13 +1329,13 @@ dependencies = [
 
 [[package]]
 name = "rust-htslib"
-version = "0.36.0"
+version = "0.44.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b6d2e5f7980deaf4f41366a5b0d51c2cadaf8639bb12d1258fdab87f37007bd9"
+checksum = "7c7eb0f29fce64a4e22578905efef3d72389058016023279a58b282eb5c0c467"
 dependencies = [
  "bio-types",
+ "byteorder",
  "custom_derive",
- "derefable",
  "derive-new",
  "hts-sys",
  "ieee754",
@@ -1345,7 +1344,6 @@ dependencies = [
  "linear-map",
  "newtype_derive",
  "regex",
- "strum_macros 0.20.1",
  "thiserror",
  "url",
 ]