diff --git a/.github/workflows/pr-differences-mutants.yml b/.github/workflows/pr-differences-mutants.yml
index 831d9156c1..3c0403c00f 100644
--- a/.github/workflows/pr-differences-mutants.yml
+++ b/.github/workflows/pr-differences-mutants.yml
@@ -23,8 +23,10 @@ jobs:
     runs-on: ubuntu-latest
 
     outputs:
-      run_big_packages: ${{ steps.check_packages_and_shards.outputs.run_big_packages }}
-      big_packages_with_shards: ${{ steps.check_packages_and_shards.outputs.big_packages_with_shards }}
+      run_stackslib: ${{ steps.check_packages_and_shards.outputs.run_stackslib }}
+      stackslib_with_shards: ${{ steps.check_packages_and_shards.outputs.stackslib_with_shards }}
+      run_stacks_node: ${{ steps.check_packages_and_shards.outputs.run_stacks_node }}
+      stacks_node_with_shards: ${{ steps.check_packages_and_shards.outputs.stacks_node_with_shards }}
       run_small_packages: ${{ steps.check_packages_and_shards.outputs.run_small_packages }}
       small_packages_with_shards: ${{ steps.check_packages_and_shards.outputs.small_packages_with_shards }}
       run_stacks_signer: ${{ steps.check_packages_and_shards.outputs.run_stacks_signer }}
@@ -47,7 +49,7 @@ jobs:
       - name: Run mutants on diffs
         uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
         with:
-          package-dimension: "small"
+          package: "small"
 
   # Mutation testing - Execute on PR on small packages that have functions modified (run with strategy matrix shards)
   pr-differences-mutants-small-shards:
@@ -69,15 +71,15 @@ jobs:
         uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
         with:
           shard: ${{ matrix.shard }}
-          package-dimension: "small"
+          package: "small"
 
-  # Mutation testing - Execute on PR on big packages that have functions modified (normal run, no shards)
-  pr-differences-mutants-big-normal:
-    name: Mutation Testing - Normal, Big
+  # Mutation testing - Execute on PR on stackslib package (normal run, no shards)
+  pr-differences-mutants-stackslib-normal:
+    name: Mutation Testing - Normal, Stackslib
 
     needs: check-big-packages-and-shards
 
-    if: ${{ needs.check-big-packages-and-shards.outputs.run_big_packages == 'true' && needs.check-big-packages-and-shards.outputs.big_packages_with_shards == 'false' }}
+    if: ${{ needs.check-big-packages-and-shards.outputs.run_stackslib == 'true' && needs.check-big-packages-and-shards.outputs.stackslib_with_shards == 'false' }}
 
     runs-on: ubuntu-latest
 
@@ -88,15 +90,15 @@ jobs:
           RUST_BACKTRACE: full
         uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
         with:
-          package-dimension: "big"
+          package: "stackslib"
 
-  # Mutation testing - Execute on PR on big packages that have functions modified (run with strategy matrix shards)
-  pr-differences-mutants-big-shards:
-    name: Mutation Testing - Shards, Big
+  # Mutation testing - Execute on PR on stackslib package (run with strategy matrix shards)
+  pr-differences-mutants-stackslib-shards:
+    name: Mutation Testing - Shards, Stackslib
 
     needs: check-big-packages-and-shards
 
-    if: ${{ needs.check-big-packages-and-shards.outputs.run_big_packages == 'true' && needs.check-big-packages-and-shards.outputs.big_packages_with_shards == 'true' }}
+    if: ${{ needs.check-big-packages-and-shards.outputs.run_stackslib == 'true' && needs.check-big-packages-and-shards.outputs.stackslib_with_shards == 'true' }}
 
     runs-on: ubuntu-latest
 
@@ -113,23 +115,67 @@ jobs:
         uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
         with:
           shard: ${{ matrix.shard }}
-          package-dimension: "big"
+          package: "stackslib"
 
-  # Mutation testing - Execute on PR on stacks-signer package if it has functions modified (normal run, no shards)
-  pr-differences-mutants-stacks-signer:
-    name: Mutation Testing - Normal, Signer
+  # Mutation testing - Execute on PR on stacks-node package (normal run, no shards)
+  pr-differences-mutants-stacks-node-normal:
+    name: Mutation Testing - Normal, Stacks Node
 
     needs: check-big-packages-and-shards
 
-    if: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_signer == 'true' }}
+    if: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_node == 'true' && needs.check-big-packages-and-shards.outputs.stacks_node_with_shards == 'false' }}
+
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Run Run mutants on diffs
+        env:
+          BITCOIND_TEST: 1
+          RUST_BACKTRACE: full
+        uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
+        with:
+          package: "stacks-node"
+
+  # Mutation testing - Execute on PR on stacks-node package (run with strategy matrix shards)
+  pr-differences-mutants-stacks-node-shards:
+    name: Mutation Testing - Shards, Stacks Node
+
+    needs: check-big-packages-and-shards
+
+    if: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_node == 'true' && needs.check-big-packages-and-shards.outputs.stacks_node_with_shards == 'true' }}
 
     runs-on: ubuntu-latest
 
+    strategy:
+      fail-fast: false
+      matrix:
+        shard: [0, 1, 2, 3]
+
     steps:
       - name: Run mutants on diffs
+        env:
+          BITCOIND_TEST: 1
+          RUST_BACKTRACE: full
+        uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
+        with:
+          shard: ${{ matrix.shard }}
+          package: "stacks-node"
+
+  # Mutation testing - Execute on PR on stacks-signer package (normal run, no shards)
+  pr-differences-mutants-stacks-signer-normal:
+    name: Mutation Testing - Normal, Stacks Signer
+
+    needs: check-big-packages-and-shards
+
+    if: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_signer == 'true' }}
+
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Run Run mutants on diffs
         uses: stacks-network/actions/stacks-core/mutation-testing/pr-differences@feat/mutation-testing
         with:
-          package-dimension: "stacks-signer"
+          package: "stacks-signer"
 
   # Output the mutants and fail the workflow if there are missed/timeout/unviable mutants
   output-mutants:
@@ -137,22 +183,27 @@ jobs:
 
     runs-on: ubuntu-latest
 
+    if: always()
     needs:
       [
         check-big-packages-and-shards,
         pr-differences-mutants-small-normal,
         pr-differences-mutants-small-shards,
-        pr-differences-mutants-big-normal,
-        pr-differences-mutants-big-shards,
-        pr-differences-mutants-stacks-signer,
+        pr-differences-mutants-stackslib-normal,
+        pr-differences-mutants-stackslib-shards,
+        pr-differences-mutants-stacks-node-normal,
+        pr-differences-mutants-stacks-node-shards,
+        pr-differences-mutants-stacks-signer-normal,
       ]
 
     steps:
       - name: Output Mutants
         uses: stacks-network/actions/stacks-core/mutation-testing/output-pr-mutants@feat/mutation-testing
         with:
-          big_packages: ${{ needs.check-big-packages-and-shards.outputs.run_big_packages }}
-          shards_for_big_packages: ${{ needs.check-big-packages-and-shards.outputs.big_packages_with_shards }}
+          stackslib_package: ${{ needs.check-big-packages-and-shards.outputs.run_stackslib }}
+          shards_for_stackslib_package: ${{ needs.check-big-packages-and-shards.outputs.stackslib_with_shards }}
+          stacks_node_package: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_node }}
+          shards_for_stacks_node_package: ${{ needs.check-big-packages-and-shards.outputs.stacks_node_with_shards }}
           small_packages: ${{ needs.check-big-packages-and-shards.outputs.run_small_packages }}
           shards_for_small_packages: ${{ needs.check-big-packages-and-shards.outputs.small_packages_with_shards }}
           stacks_signer: ${{ needs.check-big-packages-and-shards.outputs.run_stacks_signer }}