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model_Raimundez_PCB2020.xml
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model_Raimundez_PCB2020.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Raimundez_PCB2020" name="Raimundez_PCB2020">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#benchmark_models_petab">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/doi/10.1371/journal.pcbi.1007147"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfUnitDefinitions>
<unitDefinition id="time" name="time">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="60"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="pl" name="pl">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1e-12"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cyt" spatialDimensions="3" size="1" units="pl" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="EGFR" name="EGFR" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="EGFR_CET" name="EGFR:CET" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="EGFR_EGF" name="EGFR:EGF" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="EGFR_EGF_2" name="(EGFR:EGF)_2" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pEGFR_EGF_2" name="(pEGFR:EGF)_2" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pEGFR_EGF_2_i" name="(pEGFR:EGF)_{2,i}" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET" name="MMET" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET_2" name="MMET_2" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMMET_2" name="pMMET_2" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMMET_2_i" name="pMMET_2_i" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET_EGFR" name="MMET:EGFR" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMMET_pEGFR" name="pMMET:pEGFR" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMMET_pEGFR_i" name="pMMET:pEGFR_i" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET_METinh" name="MMET:Inhibitor" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET_MMET_METinh" name="MMET_2:Inhibitor" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="MMET_METinh_2" name="MMET_2:Inhibitor_2" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="EGFR_MMET_METinh" name="EGFR:MMET:Inhibitor" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="RAS_GTP" name="RAS:GTP" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMAPK" name="pMAPK" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pPI3K" name="pPI3K" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pMPI3K" name="pMPI3K" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="pAKT" name="pAKT" compartment="cyt" initialConcentration="1" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="AKTtotal__MKN1_fm" name="AKTtotal__MKN1_fm" value="1" constant="true"/>
<parameter id="CET_level" name="CET_level" value="1" constant="true"/>
<parameter id="EGF_level" name="EGF_level" value="1" constant="true"/>
<parameter id="HS746T" name="HS746T" value="1" constant="true"/>
<parameter id="KD_EGFR_CET" name="KD_EGFR_CET" value="0.218012149340634" constant="true"/>
<parameter id="KD_EGFR_EGF" name="KD_EGFR_EGF" value="0.320759905034371" constant="true"/>
<parameter id="KD_METinh" name="KD_METinh" value="0.0419369011942491" constant="true"/>
<parameter id="MAPKtotal__MKN1_fm" name="MAPKtotal__MKN1_fm" value="1" constant="true"/>
<parameter id="METinh_level" name="METinh_level" value="1" constant="true"/>
<parameter id="MKN1" name="MKN1" value="1" constant="true"/>
<parameter id="MPI3Ktotal__MKN1_fm" name="MPI3Ktotal__MKN1_fm" value="1" constant="true"/>
<parameter id="PI3Ktotal__HS746T_fm" name="PI3Ktotal__HS746T_fm" value="1" constant="true"/>
<parameter id="RAStotal__MKN1_fm" name="RAStotal__MKN1_fm" value="1" constant="true"/>
<parameter id="d_AKTtotal__MKN1_2_HS746T" name="d_AKTtotal__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_AKTtotal__fm_2_hm" name="d_AKTtotal__fm_2_hm" value="0.822922669170335" constant="true"/>
<parameter id="d_MAPKtotal__MKN1_2_HS746T" name="d_MAPKtotal__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_MAPKtotal__fm_2_hm" name="d_MAPKtotal__fm_2_hm" value="0.427450996540987" constant="true"/>
<parameter id="d_MPI3Ktotal__fm_2_hm" name="d_MPI3Ktotal__fm_2_hm" value="-1.54468079589527" constant="true"/>
<parameter id="d_PI3Ktotal__fm_2_hm" name="d_PI3Ktotal__fm_2_hm" value="-0.53183572852766" constant="true"/>
<parameter id="d_RAStotal__MKN1_2_HS746T" name="d_RAStotal__MKN1_2_HS746T" value="-1.05879118406788e-22" constant="true"/>
<parameter id="d_RAStotal__fm_2_hm" name="d_RAStotal__fm_2_hm" value="-0.538190130449678" constant="true"/>
<parameter id="d_ka_AKT__MKN1_2_HS746T" name="d_ka_AKT__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_ka_MAPK__MKN1_2_HS746T" name="d_ka_MAPK__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_ka_RAS__basal__MKN1_2_HS746T" name="d_ka_RAS__basal__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_ka_RAS__pEGFR_EGF_2__MKN1_2_HS746T" name="d_ka_RAS__pEGFR_EGF_2__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_kdeg_membran__MKN1_2_HS746T" name="d_kdeg_membran__MKN1_2_HS746T" value="-0.599975506316473" constant="true"/>
<parameter id="d_kdeg_pEGFR_EGF_2_i__MKN1_2_HS746T" name="d_kdeg_pEGFR_EGF_2_i__MKN1_2_HS746T" value="2.99999999999997" constant="true"/>
<parameter id="d_kexp_pEGFR_EGF_2_i__MKN1_2_HS746T" name="d_kexp_pEGFR_EGF_2_i__MKN1_2_HS746T" value="-0.23823693668421" constant="true"/>
<parameter id="d_ki_AKT__MKN1_2_HS746T" name="d_ki_AKT__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_ki_PI3K__MKN1_2_HS746T" name="d_ki_PI3K__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_ki_RAS__MKN1_2_HS746T" name="d_ki_RAS__MKN1_2_HS746T" value="0" constant="true"/>
<parameter id="d_kimp_pEGFR_EGF_2__MKN1_2_HS746T" name="d_kimp_pEGFR_EGF_2__MKN1_2_HS746T" value="-1.74579260575349" constant="true"/>
<parameter id="d_ksyn_EGFR__MKN1_2_HS746T" name="d_ksyn_EGFR__MKN1_2_HS746T" value="-2.99999999999997" constant="true"/>
<parameter id="d_ksyn_EGFR__fm_2_hm" name="d_ksyn_EGFR__fm_2_hm" value="-0.087595179128819" constant="true"/>
<parameter id="d_ksyn_MMET__fm_2_hm" name="d_ksyn_MMET__fm_2_hm" value="-0.518888973548685" constant="true"/>
<parameter id="full_medium" name="full_medium" value="1" constant="true"/>
<parameter id="hunger_medium" name="hunger_medium" value="1" constant="true"/>
<parameter id="ka_AKT__MKN1" name="ka_AKT__MKN1" value="443.101158324899" constant="true"/>
<parameter id="ka_MAPK__MKN1" name="ka_MAPK__MKN1" value="999.999999999942" constant="true"/>
<parameter id="ka_PI3K__basal" name="ka_PI3K__basal" value="0.000364915071486299" constant="true"/>
<parameter id="ka_PI3K__pEGFR_EGF_2" name="ka_PI3K__pEGFR_EGF_2" value="0.00170094333323992" constant="true"/>
<parameter id="ka_RAS__basal__MKN1" name="ka_RAS__basal__MKN1" value="0.000214463346879122" constant="true"/>
<parameter id="ka_RAS__pEGFR_EGF_2__MKN1" name="ka_RAS__pEGFR_EGF_2__MKN1" value="1.46548915399828e-05" constant="true"/>
<parameter id="kbin_EGFR_CET" name="kbin_EGFR_CET" value="0.585302658299007" constant="true"/>
<parameter id="kbin_EGFR_EGF" name="kbin_EGFR_EGF" value="8.88174858370342" constant="true"/>
<parameter id="kdeg_membran__MKN1" name="kdeg_membran__MKN1" value="0.00225906406531955" constant="true"/>
<parameter id="kdeg_pEGFR_EGF_2_i__MKN1" name="kdeg_pEGFR_EGF_2_i__MKN1" value="0.0667956122089203" constant="true"/>
<parameter id="kdim_EGFR_EGF" name="kdim_EGFR_EGF" value="0.0323948687677602" constant="true"/>
<parameter id="kdim_MMET" name="kdim_MMET" value="2.61246774136855e-05" constant="true"/>
<parameter id="kdim_MMET_EGFR" name="kdim_MMET_EGFR" value="0.0018821970256015" constant="true"/>
<parameter id="kdim_MMETinh" name="kdim_MMETinh" value="0.0312714078548831" constant="true"/>
<parameter id="kexp_pEGFR_EGF_2_i__MKN1" name="kexp_pEGFR_EGF_2_i__MKN1" value="0.75168312329534" constant="true"/>
<parameter id="ki_AKT__MKN1" name="ki_AKT__MKN1" value="18.4692967396058" constant="true"/>
<parameter id="ki_MAPK" name="ki_MAPK" value="2.17715931380425" constant="true"/>
<parameter id="ki_PI3K__MKN1" name="ki_PI3K__MKN1" value="1.31587984277014" constant="true"/>
<parameter id="ki_RAS__MKN1" name="ki_RAS__MKN1" value="0.326956568863966" constant="true"/>
<parameter id="kimp_pEGFR_EGF_2__MKN1" name="kimp_pEGFR_EGF_2__MKN1" value="0.746870204508838" constant="true"/>
<parameter id="kpho_EGFR_EGF" name="kpho_EGFR_EGF" value="1.34412787040515" constant="true"/>
<parameter id="kpho_MMET" name="kpho_MMET" value="2.54267401784407" constant="true"/>
<parameter id="kpho_MMET_EGFR" name="kpho_MMET_EGFR" value="4.56300939074226" constant="true"/>
<parameter id="ksyn_EGFR__MKN1_fm" name="ksyn_EGFR__MKN1_fm" value="1" constant="true"/>
<parameter id="ksyn_MMET__HS746T_fm" name="ksyn_MMET__HS746T_fm" value="0.0263508050701968" constant="true"/>
<parameter id="relative_ksyn_EGFR" name="relative_ksyn_EGFR" value="1" constant="true"/>
<parameter id="xi_ka_PI3K_pMMET_2" name="xi_ka_PI3K_pMMET_2" value="301.340865539045" constant="true"/>
<parameter id="xi_ka_PI3K_pMMET_pEGFR" name="xi_ka_PI3K_pMMET_pEGFR" value="0.765472157713775" constant="true"/>
<parameter id="xi_ka_RAS_pMMET_2" name="xi_ka_RAS_pMMET_2" value="0.449351471804434" constant="true"/>
<parameter id="xi_ka_RAS_pMMET_pEGFR" name="xi_ka_RAS_pMMET_pEGFR" value="0.253561151358926" constant="true"/>
<parameter id="xi_kdeg_pMMET_2_i" name="xi_kdeg_pMMET_2_i" value="0.783710318142686" constant="true"/>
<parameter id="xi_kdeg_pMMET_pEGFR_i" name="xi_kdeg_pMMET_pEGFR_i" value="3.53345024355609" constant="true"/>
<parameter id="xi_kdim_MMET" name="xi_kdim_MMET" value="0.974771379091693" constant="true"/>
<parameter id="xi_kdim_MMET_EGFR" name="xi_kdim_MMET_EGFR" value="1.00042475919183" constant="true"/>
<parameter id="xi_kexp_pMMET_2_i" name="xi_kexp_pMMET_2_i" value="1.24320885340702" constant="true"/>
<parameter id="xi_kexp_pMMET_pEGFR_i" name="xi_kexp_pMMET_pEGFR_i" value="0.286399421450953" constant="true"/>
<parameter id="xi_ki_MPI3K" name="xi_ki_MPI3K" value="0.0032202841840531" constant="true"/>
<parameter id="xi_kimp_pMMET_2" name="xi_kimp_pMMET_2" value="0.0771538780627502" constant="true"/>
<parameter id="xi_kimp_pMMET_pEGFR" name="xi_kimp_pMMET_pEGFR" value="0.00796005343654933" constant="true"/>
<parameter id="xi_kpho_MMET" name="xi_kpho_MMET" value="0.00832776881377235" constant="true"/>
<parameter id="xi_kpho_MMET_EGFR" name="xi_kpho_MMET_EGFR" value="0.0696731441268168" constant="true"/>
<parameter id="EGF" name="EGF" value="0" constant="false"/>
<parameter id="CET" name="CET" value="0" constant="false"/>
<parameter id="METinh" name="METinh" value="0" constant="false"/>
<parameter id="FM" name="FM" value="0" constant="false"/>
<parameter id="HM" name="HM" value="0" constant="false"/>
<parameter id="ksyn_MMET" name="ksyn_MMET" value="0" constant="false"/>
<parameter id="ksyn_EGFR" name="ksyn_EGFR" value="0" constant="false"/>
<parameter id="RAS_total" name="RAS_total" value="0" constant="false"/>
<parameter id="MAPK_total" name="MAPK_total" value="0" constant="false"/>
<parameter id="PI3K_total" name="PI3K_total" value="0" constant="false"/>
<parameter id="MPI3K_total" name="MPI3K_total" value="0" constant="false"/>
<parameter id="AKT_total" name="AKT_total" value="0" constant="false"/>
<parameter id="kimp_pEGFR_EGF_2" name="kimp_pEGFR_EGF_2" value="0" constant="false"/>
<parameter id="kdeg_pEGFR_EGF_2_i" name="kdeg_pEGFR_EGF_2_i" value="0" constant="false"/>
<parameter id="kdeg_membran" name="kdeg_membran" value="0" constant="false"/>
<parameter id="kexp_pEGFR_EGF_2_i" name="kexp_pEGFR_EGF_2_i" value="0" constant="false"/>
<parameter id="ka_RAS__basal" name="ka_RAS__basal" value="0" constant="false"/>
<parameter id="ka_RAS__pEGFR_EGF_2" name="ka_RAS__pEGFR_EGF_2" value="0" constant="false"/>
<parameter id="ki_RAS" name="ki_RAS" value="0" constant="false"/>
<parameter id="ka_MAPK" name="ka_MAPK" value="0" constant="false"/>
<parameter id="ka_AKT" name="ka_AKT" value="0" constant="false"/>
<parameter id="ki_AKT" name="ki_AKT" value="0" constant="false"/>
<parameter id="ki_PI3K" name="ki_PI3K" value="0" constant="false"/>
</listOfParameters>
<listOfInitialAssignments>
<initialAssignment symbol="EGFR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="EGFR_CET">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="EGFR_EGF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="EGFR_EGF_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pEGFR_EGF_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pEGFR_EGF_2_i">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMMET_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMMET_2_i">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET_EGFR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMMET_pEGFR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMMET_pEGFR_i">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET_METinh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET_MMET_METinh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="MMET_METinh_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="EGFR_MMET_METinh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="RAS_GTP">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMAPK">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pPI3K">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pMPI3K">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
<initialAssignment symbol="pAKT">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn type="integer"> 0 </cn>
</math>
</initialAssignment>
</listOfInitialAssignments>
<listOfRules>
<assignmentRule variable="EGF">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<cn> 0.161 </cn>
<ci> EGF_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="CET">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<cn> 6.86 </cn>
<ci> CET_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="METinh">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> METinh_level </ci>
<piecewise>
<piece>
<cn type="integer"> 0 </cn>
<apply>
<lt/>
<csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
<cn type="integer"> 0 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="FM">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> full_medium </ci>
</math>
</assignmentRule>
<assignmentRule variable="HM">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> hunger_medium </ci>
</math>
</assignmentRule>
<assignmentRule variable="ksyn_MMET">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> HS746T </ci>
<ci> ksyn_MMET__HS746T_fm </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> d_ksyn_MMET__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ksyn_EGFR">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ksyn_EGFR__MKN1_fm </ci>
<ci> relative_ksyn_EGFR </ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ksyn_EGFR__MKN1_2_HS746T </ci>
</apply>
<apply>
<times/>
<ci> d_ksyn_EGFR__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="RAS_total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> RAStotal__MKN1_fm </ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_RAStotal__MKN1_2_HS746T </ci>
</apply>
<apply>
<times/>
<ci> d_RAStotal__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="MAPK_total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> MAPKtotal__MKN1_fm </ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_MAPKtotal__MKN1_2_HS746T </ci>
</apply>
<apply>
<times/>
<ci> d_MAPKtotal__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="PI3K_total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> HS746T </ci>
<ci> PI3Ktotal__HS746T_fm </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> d_PI3Ktotal__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="MPI3K_total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> MKN1 </ci>
<ci> MPI3Ktotal__MKN1_fm </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> d_MPI3Ktotal__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="AKT_total">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> AKTtotal__MKN1_fm </ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_AKTtotal__MKN1_2_HS746T </ci>
</apply>
<apply>
<times/>
<ci> d_AKTtotal__fm_2_hm </ci>
<ci> hunger_medium </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="kimp_pEGFR_EGF_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kimp_pEGFR_EGF_2__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_kimp_pEGFR_EGF_2__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="kdeg_pEGFR_EGF_2_i">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdeg_pEGFR_EGF_2_i__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_kdeg_pEGFR_EGF_2_i__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="kdeg_membran">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kdeg_membran__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_kdeg_membran__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="kexp_pEGFR_EGF_2_i">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kexp_pEGFR_EGF_2_i__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_kexp_pEGFR_EGF_2_i__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ka_RAS__basal">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ka_RAS__basal__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ka_RAS__basal__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ka_RAS__pEGFR_EGF_2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ka_RAS__pEGFR_EGF_2__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ka_RAS__pEGFR_EGF_2__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ki_RAS">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ki_RAS__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ki_RAS__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ka_MAPK">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ka_MAPK__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ka_MAPK__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ka_AKT">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ka_AKT__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ka_AKT__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ki_AKT">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ki_AKT__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ki_AKT__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="ki_PI3K">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> ki_PI3K__MKN1 </ci>
<apply>
<exp/>
<apply>
<times/>
<ci> HS746T </ci>
<ci> d_ki_PI3K__MKN1_2_HS746T </ci>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="v1_v_0" name="v_0" reversible="false">
<listOfProducts>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> ksyn_EGFR </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v2_v_1" name="v_1" reversible="false">
<listOfReactants>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v3_v_2" name="v_2" reversible="false">
<listOfReactants>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR_CET" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> CET </ci>
<ci> EGFR </ci>
<ci> kbin_EGFR_CET </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v4_v_3" name="v_3" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_CET" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_CET </ci>
<ci> KD_EGFR_CET </ci>
<ci> kbin_EGFR_CET </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v5_v_4" name="v_4" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_CET" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_CET </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v6_v_5" name="v_5" reversible="false">
<listOfReactants>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR_EGF" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGF </ci>
<ci> EGFR </ci>
<ci> kbin_EGFR_EGF </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v7_v_6" name="v_6" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_EGF" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_EGF </ci>
<ci> KD_EGFR_EGF </ci>
<ci> kbin_EGFR_EGF </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v8_v_7" name="v_7" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_EGF" stoichiometry="2"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR_EGF_2" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<apply>
<power/>
<ci> EGFR_EGF </ci>
<cn type="integer"> 2 </cn>
</apply>
<ci> kdim_EGFR_EGF </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v9_v_8" name="v_8" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_EGF_2" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pEGFR_EGF_2" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_EGF_2 </ci>
<ci> kpho_EGFR_EGF </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v10_v_9" name="v_9" reversible="false">
<listOfReactants>
<speciesReference species="pEGFR_EGF_2" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="pEGFR_EGF_2_i" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> kimp_pEGFR_EGF_2 </ci>
<ci> pEGFR_EGF_2 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v11_v_10" name="v_10" reversible="false">
<listOfReactants>
<speciesReference species="pEGFR_EGF_2_i" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="EGFR" stoichiometry="2"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> kexp_pEGFR_EGF_2_i </ci>
<ci> pEGFR_EGF_2_i </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v12_v_11" name="v_11" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_EGF" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_EGF </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v13_v_12" name="v_12" reversible="false">
<listOfReactants>
<speciesReference species="EGFR_EGF_2" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> EGFR_EGF_2 </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v14_v_13" name="v_13" reversible="false">
<listOfReactants>
<speciesReference species="pEGFR_EGF_2_i" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> kdeg_pEGFR_EGF_2_i </ci>
<ci> pEGFR_EGF_2_i </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v15_v_14" name="v_14" reversible="false">
<listOfProducts>
<speciesReference species="MMET" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> ksyn_MMET </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v16_v_15" name="v_15" reversible="false">
<listOfReactants>
<speciesReference species="MMET" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> MMET </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v17_v_16" name="v_16" reversible="false">
<listOfReactants>
<speciesReference species="MMET" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MMET_METinh" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> METinh </ci>
<ci> MMET </ci>
<ci> kdim_MMETinh </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v18_v_17" name="v_17" reversible="false">
<listOfReactants>
<speciesReference species="MMET_METinh" stoichiometry="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MMET" stoichiometry="1"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> KD_METinh </ci>
<ci> MMET_METinh </ci>
<ci> kdim_MMETinh </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v19_v_18" name="v_18" reversible="false">
<listOfReactants>
<speciesReference species="MMET_METinh" stoichiometry="1"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> cyt </ci>
<ci> MMET_METinh </ci>
<ci> kdeg_membran </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="v20_v_19" name="v_19" reversible="false">
<listOfReactants>
<speciesReference species="MMET" stoichiometry="2"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="MMET_2" stoichiometry="1"/>
</listOfProducts>