diff --git a/src/arch/aarch64/memchr.rs b/src/arch/aarch64/memchr.rs
index e0053b2..4d96b16 100644
--- a/src/arch/aarch64/memchr.rs
+++ b/src/arch/aarch64/memchr.rs
@@ -8,7 +8,7 @@ available for `aarch64` targets.)
 
 macro_rules! defraw {
     ($ty:ident, $find:ident, $start:ident, $end:ident, $($needles:ident),+) => {{
-        #[cfg(target_feature = "neon")]
+        #[cfg(all(target_feature = "neon", target_endian = "little"))]
         {
             use crate::arch::aarch64::neon::memchr::$ty;
 
@@ -19,7 +19,7 @@ macro_rules! defraw {
             // enabled.
             $ty::new_unchecked($($needles),+).$find($start, $end)
         }
-        #[cfg(not(target_feature = "neon"))]
+        #[cfg(not(all(target_feature = "neon", target_endian = "little")))]
         {
             use crate::arch::all::memchr::$ty;
 
diff --git a/src/arch/aarch64/mod.rs b/src/arch/aarch64/mod.rs
index 7b32912..7262414 100644
--- a/src/arch/aarch64/mod.rs
+++ b/src/arch/aarch64/mod.rs
@@ -2,6 +2,8 @@
 Vector algorithms for the `aarch64` target.
 */
 
+#[cfg(target_endian = "little")]
 pub mod neon;
 
+#[cfg(target_endian = "little")]
 pub(crate) mod memchr;
diff --git a/src/memchr.rs b/src/memchr.rs
index 92a18bd..665adbf 100644
--- a/src/memchr.rs
+++ b/src/memchr.rs
@@ -518,14 +518,14 @@ unsafe fn memchr_raw(
     {
         crate::arch::wasm32::memchr::memchr_raw(needle, start, end)
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memchr_raw(needle, start, end)
     }
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::One::new(needle).find_raw(start, end)
@@ -551,14 +551,14 @@ unsafe fn memrchr_raw(
     {
         crate::arch::wasm32::memchr::memrchr_raw(needle, start, end)
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memrchr_raw(needle, start, end)
     }
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::One::new(needle).rfind_raw(start, end)
@@ -585,14 +585,14 @@ unsafe fn memchr2_raw(
     {
         crate::arch::wasm32::memchr::memchr2_raw(needle1, needle2, start, end)
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memchr2_raw(needle1, needle2, start, end)
     }
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::Two::new(needle1, needle2)
@@ -620,7 +620,7 @@ unsafe fn memrchr2_raw(
     {
         crate::arch::wasm32::memchr::memrchr2_raw(needle1, needle2, start, end)
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memrchr2_raw(
             needle1, needle2, start, end,
@@ -629,7 +629,7 @@ unsafe fn memrchr2_raw(
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::Two::new(needle1, needle2)
@@ -662,7 +662,7 @@ unsafe fn memchr3_raw(
             needle1, needle2, needle3, start, end,
         )
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memchr3_raw(
             needle1, needle2, needle3, start, end,
@@ -671,7 +671,7 @@ unsafe fn memchr3_raw(
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::Three::new(needle1, needle2, needle3)
@@ -704,7 +704,7 @@ unsafe fn memrchr3_raw(
             needle1, needle2, needle3, start, end,
         )
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::memrchr3_raw(
             needle1, needle2, needle3, start, end,
@@ -713,7 +713,7 @@ unsafe fn memrchr3_raw(
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::Three::new(needle1, needle2, needle3)
@@ -736,14 +736,14 @@ unsafe fn count_raw(needle: u8, start: *const u8, end: *const u8) -> usize {
     {
         crate::arch::wasm32::memchr::count_raw(needle, start, end)
     }
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     {
         crate::arch::aarch64::memchr::count_raw(needle, start, end)
     }
     #[cfg(not(any(
         target_arch = "x86_64",
         all(target_arch = "wasm32", target_feature = "simd128"),
-        target_arch = "aarch64"
+        all(target_arch = "aarch64", target_endian = "little")
     )))]
     {
         crate::arch::all::memchr::One::new(needle).count_raw(start, end)
diff --git a/src/memmem/searcher.rs b/src/memmem/searcher.rs
index 2a533e0..fbca707 100644
--- a/src/memmem/searcher.rs
+++ b/src/memmem/searcher.rs
@@ -3,7 +3,7 @@ use crate::arch::all::{
     rabinkarp, twoway,
 };
 
-#[cfg(target_arch = "aarch64")]
+#[cfg(all(target_arch = "aarch64", target_endian = "little"))]
 use crate::arch::aarch64::neon::packedpair as neon;
 #[cfg(all(target_arch = "wasm32", target_feature = "simd128"))]
 use crate::arch::wasm32::simd128::packedpair as simd128;
@@ -129,7 +129,7 @@ impl Searcher {
                 Searcher::twoway(needle, rabinkarp, prestrat)
             }
         }
-        #[cfg(target_arch = "aarch64")]
+        #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
         {
             if let Some(pp) = neon::Finder::with_pair(needle, pair) {
                 if do_packed_search(needle) {
@@ -152,7 +152,7 @@ impl Searcher {
         #[cfg(not(any(
             all(target_arch = "x86_64", target_feature = "sse2"),
             all(target_arch = "wasm32", target_feature = "simd128"),
-            target_arch = "aarch64"
+            all(target_arch = "aarch64", target_endian = "little")
         )))]
         {
             if prefilter.is_none() {
@@ -253,7 +253,7 @@ union SearcherKind {
     avx2: crate::arch::x86_64::avx2::packedpair::Finder,
     #[cfg(all(target_arch = "wasm32", target_feature = "simd128"))]
     simd128: crate::arch::wasm32::simd128::packedpair::Finder,
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     neon: crate::arch::aarch64::neon::packedpair::Finder,
 }
 
@@ -421,7 +421,7 @@ unsafe fn searcher_kind_simd128(
 /// # Safety
 ///
 /// Callers must ensure that the `searcher.kind.neon` union field is set.
-#[cfg(target_arch = "aarch64")]
+#[cfg(all(target_arch = "aarch64", target_endian = "little"))]
 unsafe fn searcher_kind_neon(
     searcher: &Searcher,
     _prestate: &mut PrefilterState,
@@ -686,7 +686,7 @@ impl Prefilter {
     }
 
     /// Return a prefilter using a aarch64 neon vector algorithm.
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     #[inline]
     fn neon(finder: neon::Finder, needle: &[u8]) -> Prefilter {
         trace!("building aarch64 neon prefilter");
@@ -763,7 +763,7 @@ union PrefilterKind {
     avx2: crate::arch::x86_64::avx2::packedpair::Finder,
     #[cfg(all(target_arch = "wasm32", target_feature = "simd128"))]
     simd128: crate::arch::wasm32::simd128::packedpair::Finder,
-    #[cfg(target_arch = "aarch64")]
+    #[cfg(all(target_arch = "aarch64", target_endian = "little"))]
     neon: crate::arch::aarch64::neon::packedpair::Finder,
 }
 
@@ -852,7 +852,7 @@ unsafe fn prefilter_kind_simd128(
 /// # Safety
 ///
 /// Callers must ensure that the `strat.kind.neon` union field is set.
-#[cfg(target_arch = "aarch64")]
+#[cfg(all(target_arch = "aarch64", target_endian = "little"))]
 unsafe fn prefilter_kind_neon(
     strat: &Prefilter,
     haystack: &[u8],
diff --git a/src/vector.rs b/src/vector.rs
index d86fbca..9ab4db6 100644
--- a/src/vector.rs
+++ b/src/vector.rs
@@ -289,7 +289,7 @@ mod x86avx2 {
     }
 }
 
-#[cfg(target_arch = "aarch64")]
+#[cfg(all(target_arch = "aarch64", target_endian = "little"))]
 mod aarch64neon {
     use core::arch::aarch64::*;