- Support added for computing median and modal sample sizes.
- 'Code for reproduction' box added to the GUI.
- Support added for clinical trials with Poisson distributed outcomes
(
build_dtl_pois(),build_gs_pois(),build_ss_pois(),des_dtl_pois(),des_gs_pois(),des_ss_pois(),opchar_dtl_pois(),opchar_gs_pois(),opchar_ss_pois(),plot.multiarm_des_dtl_pois(),plot.multiarm_des_gs_pois(),plot.multiarm_des_ss_pois(),sim_dtl_pois(),sim_gs_pois(),sim_ss_pois()).
- Analysis functions removed; focus purely on design for now.
- Support added for group-sequential multi-arm multi-stage clinical trials with
normally or Bernoulli distributed outcomes (
build_gs_bern(),build_gs_norm(),des_gs_bern(),des_gs_norm(),opchar_gs_bern(),opchar_gs_norm(),plot.multiarm_des_gs_bern(),plot.multiarm_des_gs_norm(),sim_gs_bern(),sim_gs_norm()). - Corresponding support also added for multi-stage drop-the-losers designs
(
build_dtl_bern(),build_dtl_norm(),des_dtl_bern(),des_dtl_norm(),opchar_dtl_bern(),opchar_dtl_norm(),plot.multiarm_des_dtl_bern(),plot.multiarm_des_dtl_norm(),sim_dtl_bern(),sim_dtl_norm()). - Suffix of
_normadded to all relevant functions given below to indicate outcome variable. _ma_replaced in function names with_ss_.des_int_ma()removed for simplicity; does not add much overdes_ss_norm().
- Corresponding support added for trials with Bernoulli outcomes
(
an_ma_bern(),build_ma_bern(),des_ma_bern(),opchar_ma(),plot.multiarm_des_ma_bern(),sim_ma_bern()). gui_ma()renamedgui()to reflect use for multiple types of outcome.
- Package launched with support for the design (
build_ma(),des_ma(),des_int_ma()), assessment (opchar_ma()), analysis (an_ma()), simulation (sim_ma()), and visualisation (plot.multiarm_des_ma()) of single-stage multi-arm clinical trials with normally distributed outcomes. An R Shiny graphical user interface is also provided (gui_ma()).