diff --git a/ddtrace/internal/datadog/profiling/stack_v2/src/stack_v2.cpp b/ddtrace/internal/datadog/profiling/stack_v2/src/stack_v2.cpp
index 5548be35c2c..db56b0f6457 100644
--- a/ddtrace/internal/datadog/profiling/stack_v2/src/stack_v2.cpp
+++ b/ddtrace/internal/datadog/profiling/stack_v2/src/stack_v2.cpp
@@ -73,7 +73,10 @@ stack_v2_thread_register(PyObject* self, PyObject* args)
         return NULL;
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().register_thread(id, native_id, name);
+    Py_END_ALLOW_THREADS;
+
     Py_RETURN_NONE;
 }
 
@@ -87,8 +90,11 @@ stack_v2_thread_unregister(PyObject* self, PyObject* args)
         return NULL;
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().unregister_thread(id);
     ThreadSpanLinks::get_instance().unlink_span(id);
+    Py_END_ALLOW_THREADS;
+
     Py_RETURN_NONE;
 }
 
@@ -122,7 +128,9 @@ _stack_v2_link_span(PyObject* self, PyObject* args, PyObject* kwargs)
         span_type = empty_string.c_str();
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     ThreadSpanLinks::get_instance().link_span(thread_id, span_id, local_root_span_id, std::string(span_type));
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -140,7 +148,9 @@ stack_v2_track_asyncio_loop(PyObject* self, PyObject* args)
         return NULL;
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().track_asyncio_loop(thread_id, loop);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -172,7 +182,9 @@ stack_v2_link_tasks(PyObject* self, PyObject* args)
         return NULL;
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().link_tasks(parent, child);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -211,7 +223,9 @@ track_greenlet(PyObject* Py_UNUSED(m), PyObject* args)
         return NULL;
     }
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().track_greenlet(greenlet_id, greenlet_name, frame);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -223,7 +237,9 @@ untrack_greenlet(PyObject* Py_UNUSED(m), PyObject* args)
     if (!PyArg_ParseTuple(args, "l", &greenlet_id))
         return NULL;
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().untrack_greenlet(greenlet_id);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -236,7 +252,9 @@ link_greenlets(PyObject* Py_UNUSED(m), PyObject* args)
     if (!PyArg_ParseTuple(args, "ll", &child, &parent))
         return NULL;
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().link_greenlets(parent, child);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
@@ -250,7 +268,9 @@ update_greenlet_frame(PyObject* Py_UNUSED(m), PyObject* args)
     if (!PyArg_ParseTuple(args, "lO", &greenlet_id, &frame))
         return NULL;
 
+    Py_BEGIN_ALLOW_THREADS;
     Sampler::get().update_greenlet_frame(greenlet_id, frame);
+    Py_END_ALLOW_THREADS;
 
     Py_RETURN_NONE;
 }
diff --git a/releasenotes/notes/fix-profiler-release-gil-internal-mutation-2f0fc19f83759a72.yaml b/releasenotes/notes/fix-profiler-release-gil-internal-mutation-2f0fc19f83759a72.yaml
new file mode 100644
index 00000000000..f3028aa0f0b
--- /dev/null
+++ b/releasenotes/notes/fix-profiler-release-gil-internal-mutation-2f0fc19f83759a72.yaml
@@ -0,0 +1,4 @@
+---
+fixes:
+  - |
+    Profiling: prevent potential deadlocks with thread pools.