diff --git a/.builders/images/runner_dependencies.txt b/.builders/images/runner_dependencies.txt
index 192632213f618..657c0f71a8737 100644
--- a/.builders/images/runner_dependencies.txt
+++ b/.builders/images/runner_dependencies.txt
@@ -2,4 +2,5 @@ python-dotenv==1.0.0
 urllib3==2.1.0
 auditwheel==5.4.0; sys_platform == 'linux'
 delvewheel==1.5.2; sys_platform == 'win32'
-delocate==0.10.7; sys_platform == 'darwin'
+# Custom patch to be able to strip (sanitize) absolute rpaths
+delocate @ git+https://github.com/DataDog/delocate.git@8423951d8ff69bb5f3c7a1c44689c59b5c4ea4e3; sys_platform == 'darwin'
diff --git a/.builders/scripts/repair_wheels.py b/.builders/scripts/repair_wheels.py
index 16ae60c1d9ee3..7c3cd8c6baf0c 100644
--- a/.builders/scripts/repair_wheels.py
+++ b/.builders/scripts/repair_wheels.py
@@ -164,6 +164,7 @@ def copy_filt_func(libname):
             str(wheel),
             os.path.join(output_dir, os.path.basename(wheel)),
             copy_filt_func=copy_filt_func,
+            sanitize_rpaths=True,
         )
         print('Repaired wheel')
         if copied_libs: