From 1a56cee56db828db2208d62142e915aeeec4cb9a Mon Sep 17 00:00:00 2001
From: Ontobot <ontolobot@gmail.com>
Date: Tue, 26 Sep 2023 18:36:34 +0000
Subject: [PATCH] Automated commit.

---
 models/AOP_54.ttl | 294 ++++++++++++++++++++++++++++++++++++++--------
 1 file changed, 246 insertions(+), 48 deletions(-)

diff --git a/models/AOP_54.ttl b/models/AOP_54.ttl
index f6da8cd5..8d5be540 100644
--- a/models/AOP_54.ttl
+++ b/models/AOP_54.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_54> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -13,6 +15,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002566> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0004021> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -33,39 +37,60 @@
 
 <http://purl.obolibrary.org/obo/MP_0005475> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005475> .
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	<http://geneontology.org/lego/hint/layout/x> "291.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2236.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005475> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#iodide> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16382> .
+<http://www.co-ode.org/ontologies/ont.owl#iodide> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16382> .
 
-<http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0015705> .
+<http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#iodide> ;
+	<http://geneontology.org/lego/hint/layout/x> "282.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2605.9999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0015705> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_60311> .
+	<http://geneontology.org/lego/hint/layout/x> "652.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2409.9999237060547"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_60311> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://geneontology.org/lego/hint/layout/x> "289.88331604003906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2401.7499237060547"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006590> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "671.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2251.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006590> .
+<http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
-	<http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> .
+<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://geneontology.org/lego/hint/layout/x> "482.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1843.9999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
+<http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> .
+<http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/GO_0045202> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synapse> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0045202> .
+<http://www.co-ode.org/ontologies/ont.owl#synapse> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0045202> .
 
 <http://purl.obolibrary.org/obo/GO_0008507> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -74,16 +99,25 @@
 <http://purl.obolibrary.org/obo/PR_000015171> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010817> .
+	<http://geneontology.org/lego/hint/layout/x> "282.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2036.2499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010817> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#sodium/iodide%20cotransporter> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000015171> .
-
-<http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008507> .
+	<http://geneontology.org/lego/hint/layout/x> "621.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2758.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000015171> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> <http://geneontology.org/lego/hint/layout/x> "276"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2762.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008507> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0046903> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -91,37 +125,201 @@
 
 <http://purl.obolibrary.org/obo/GO_0007613> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#learning> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> .
+<http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "539.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1184.000015258789"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#memory> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> .
+<http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "152"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1174"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> .
+<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002566> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	<http://geneontology.org/lego/hint/layout/x> "327.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1301.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000004716> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> .
+<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://geneontology.org/lego/hint/layout/x> "17.000015258789062"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1947.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#secretion> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> .
+<http://www.co-ode.org/ontologies/ont.owl#secretion> <http://geneontology.org/lego/hint/layout/x> "151.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1836"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007416> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007416> .
+<http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
+	<http://geneontology.org/lego/hint/layout/x> "329.88331604003906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1485.4999542236328"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007416> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/MP_0002882> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002882> .
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
+	<http://geneontology.org/lego/hint/layout/x> "321.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1653.7499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002882> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_54> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_54> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment "^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment "^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000018> <http://geneontology.org/lego/hint/layout/x> "673"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2033.9999542236328"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000019> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://geneontology.org/lego/hint/layout/x> "829.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1819.9999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2987 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2988 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2989 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2990 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2991 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2992 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000018> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2993 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000019> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2994 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2995 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2996 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2997 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2998 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2999 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#iodide> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t3000 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t3001 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .