diff --git a/models/AOP_10.ttl b/models/AOP_10.ttl
index a7b4dc4e..08fa4fb7 100644
--- a/models/AOP_10.ttl
+++ b/models/AOP_10.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_10> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -11,17 +13,27 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/GO_0060079> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0060079> .
+<http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0060079> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007268> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007268> .
+<http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "993.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007268> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_17996> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -40,37 +52,134 @@
 <http://purl.obolibrary.org/obo/PR_000007771> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#chloride> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_17996> .
-
-<http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0022851> .
-
-<http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0050811> .
-
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007766> .
-
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007770> .
-
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007771> .
-
-<http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#seizures> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0051899> .
-
-<http://www.co-ode.org/ontologies/ont.owl#seizures> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000025> .
+	<http://geneontology.org/lego/hint/layout/x> "156.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1465.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_17996> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0022851> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> <http://geneontology.org/lego/hint/layout/x> "665.625"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0050811> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> <http://geneontology.org/lego/hint/layout/x> "862.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1912.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007766> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1912.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007770> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> <http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1912.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007771> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#seizures> ;
+	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0051899> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#seizures> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000025> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_10> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0000056> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2817 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2818 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2819 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2820 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2821 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2822 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2823 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2824 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#seizures> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_12.ttl b/models/AOP_12.ttl
index 155cddab..e5ad8ddc 100644
--- a/models/AOP_12.ttl
+++ b/models/AOP_12.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_12> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -22,25 +24,41 @@
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> .
+	<http://purl.obolibrary.org/obo/RO_0002234> <https://noctua.apps.renci.org/model/AOP_12/64ecbbe400000017> ;
+	<http://geneontology.org/lego/hint/layout/x> "2870.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "756.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/CHEBI_39124> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0006816> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> .
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://geneontology.org/lego/hint/layout/x> "2247"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "964"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002463> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> .
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://geneontology.org/lego/hint/layout/x> "2710.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "949.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> .
+<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://geneontology.org/lego/hint/layout/x> "2691.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "562.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -50,34 +68,42 @@
 
 <http://purl.obolibrary.org/obo/MP_0002229> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#astrocyte> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> .
+<http://www.co-ode.org/ontologies/ont.owl#astrocyte> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	<http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> .
+<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	<http://geneontology.org/lego/hint/layout/x> "2697.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "321"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> , <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
+	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> .
+<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> .
 
-<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> .
+<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://geneontology.org/lego/hint/layout/x> "2330.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "356.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004972> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0017146> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> .
+<http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "2710.7500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1122"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> .
+	<http://geneontology.org/lego/hint/layout/x> "2413.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1111"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0046903> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -85,21 +111,144 @@
 
 <http://purl.obolibrary.org/obo/GO_0007613> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#learning> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> .
+<http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "2569.7499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "172"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#memory> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> .
+<http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "2842"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "179"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000004716> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> .
+<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://geneontology.org/lego/hint/layout/x> "2218.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "766.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#secretion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> .
+	<http://geneontology.org/lego/hint/layout/x> "2575.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "773.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_12> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002463> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0003304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_12/64ecbbe400000017> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2894 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2895 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2896 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2897 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_12/64ecbbe400000017> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2898 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2899 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2900 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2901 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2902 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2903 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2904 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002463> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2905 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_131.ttl b/models/AOP_131.ttl
index 1ddfcfb4..694fcb3e 100644
--- a/models/AOP_131.ttl
+++ b/models/AOP_131.ttl
@@ -48,8 +48,8 @@
 <http://purl.obolibrary.org/obo/PR_000003858> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "93.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1644.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "100.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1649.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003858> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
@@ -74,15 +74,15 @@
 <http://purl.obolibrary.org/obo/PR_P79761> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A2> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "48.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1286.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "143.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1295.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006102> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A5%20%28chicken%29> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "926.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1281.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "832.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1289.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_P79761> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
@@ -134,28 +134,28 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2602 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t2617 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2603 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2618 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2604 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002211> ;
+_:t2619 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002211> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2605 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+_:t2620 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_15.ttl b/models/AOP_15.ttl
index 7301d239..7c9bceca 100644
--- a/models/AOP_15.ttl
+++ b/models/AOP_15.ttl
@@ -15,6 +15,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/CHEBI_16991> a <http://www.w3.org/2002/07/owl#Class> .
@@ -27,7 +29,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "350.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16991> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://geneontology.org/lego/hint/layout/x> "488.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -35,7 +37,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002305> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006305> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://geneontology.org/lego/hint/layout/x> "484.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -43,23 +45,23 @@
 	<http://purl.obolibrary.org/obo/RO_0002412> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006281> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D009154> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mutation> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
+<http://www.co-ode.org/ontologies/ont.owl#mutation> <http://purl.obolibrary.org/obo/RO_0000057> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://geneontology.org/lego/hint/layout/x> "482.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "124"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009154> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_15> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://www.w3.org/2002/07/owl#versionIRI> <https://noctua.apps.renci.org/model/AOP_15> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -75,35 +77,35 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2414 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t2749 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000057> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2415 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t2750 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2416 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002305> ;
+_:t2751 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002305> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-05"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2417 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t2752 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-05"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2418 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002412> ;
+_:t2753 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002412> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_150.ttl b/models/AOP_150.ttl
index ded7f736..618c454f 100644
--- a/models/AOP_150.ttl
+++ b/models/AOP_150.ttl
@@ -19,11 +19,11 @@
 
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "735.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "173"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "733.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "145"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -37,11 +37,11 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> ;
 	<http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
-	<http://geneontology.org/lego/hint/layout/x> "579.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1181.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "644.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1187.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -53,33 +53,34 @@
 
 <http://purl.obolibrary.org/obo/PR_000004303> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> , <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> , <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
-	<http://geneontology.org/lego/hint/layout/x> "266.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1677.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
+	<http://geneontology.org/lego/hint/layout/x> "322.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1686.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003858> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "567.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1907.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "536.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1849.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004874> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20nuclear%20translocator> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
-	<http://geneontology.org/lego/hint/layout/x> "887.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1661.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20nuclear%20translocator> <http://geneontology.org/lego/hint/layout/x> "962.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1665.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004303> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "575.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1440"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "663.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1410"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046983> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0072358> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -90,40 +91,40 @@
 <http://purl.obolibrary.org/obo/UBERON_0004535> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#mortality> , <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
-	<http://geneontology.org/lego/hint/layout/x> "763.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "525.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "892.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "505.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001544> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "125.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "541.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> <http://geneontology.org/lego/hint/layout/x> "189.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "343.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0004535> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#mortality> , <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
-	<http://geneontology.org/lego/hint/layout/x> "409.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "535.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "473.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "471.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002296> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0072358> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> <http://geneontology.org/lego/hint/layout/x> "386.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "189"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0008762> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000008555> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "273"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1432.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> <http://geneontology.org/lego/hint/layout/x> "305"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1396.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000008555> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003158> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -132,11 +133,11 @@
 <http://purl.obolibrary.org/obo/PR_000017284> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "578.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "582.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "980.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0008469> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
 	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
@@ -144,20 +145,20 @@
 	<http://geneontology.org/lego/hint/layout/y> "756.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003158> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "172.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1167"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "220.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1144"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000017284> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_150> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-8688-6599"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -167,12 +168,23 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> <http://geneontology.org/lego/hint/layout/x> "589.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1659"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://purl.obolibrary.org/obo/RO_0002296> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> <http://geneontology.org/lego/hint/layout/x> "633.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1671"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046983> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000010> <http://geneontology.org/lego/hint/layout/x> "953"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1407"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003858> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -180,100 +192,114 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2570 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t2713 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2571 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+_:t2714 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2715 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2572 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+_:t2716 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2573 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2717 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2574 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+_:t2718 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2575 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t2719 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2576 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2720 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000010> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2721 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2577 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2722 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2578 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t2723 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2579 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2724 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20nuclear%20translocator> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2725 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002296> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-8688-6599"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2580 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t2726 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2581 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t2727 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2582 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+_:t2728 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t2583 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_157.ttl b/models/AOP_157.ttl
index a1604e02..8b046a06 100644
--- a/models/AOP_157.ttl
+++ b/models/AOP_157.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_157> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -18,7 +20,11 @@
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> .
+	<http://geneontology.org/lego/hint/layout/x> "348.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "199.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -30,10 +36,18 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> .
+<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "163.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "101"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> .
+	<http://geneontology.org/lego/hint/layout/x> "324.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "632.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -42,42 +56,106 @@
 <http://purl.obolibrary.org/obo/PR_000006480> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> .
+	<http://geneontology.org/lego/hint/layout/x> "638.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "622.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> .
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "614"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "107.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> .
-
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> .
-
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> .
+	<http://geneontology.org/lego/hint/layout/x> "141.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "286.49998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "566"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "548.2500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "157"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "532.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> .
+<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "307.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "406.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/UBERON_2001278> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001278> .
+<http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "686.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "399.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001278> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_157> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation "^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation "^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2926 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2927 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2928 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2929 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_158.ttl b/models/AOP_158.ttl
index 1eeb8da5..bb3486ce 100644
--- a/models/AOP_158.ttl
+++ b/models/AOP_158.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_158> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -18,7 +20,11 @@
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> .
+	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -30,10 +36,18 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> .
+<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> .
+	<http://geneontology.org/lego/hint/layout/x> "750.7350158691406"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1620.2483520507812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -41,43 +55,82 @@
 
 <http://purl.obolibrary.org/obo/PR_000006480> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> .
+<http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	<http://geneontology.org/lego/hint/layout/x> "747.8749694824219"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1923.4998168945312"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> .
+	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> .
-
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> .
-
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> .
+	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/UBERON_2001277> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001277> .
+<http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001277> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> .
+	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "993.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_158> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2610 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_360.ttl b/models/AOP_360.ttl
index e4219d7a..011fa3e0 100644
--- a/models/AOP_360.ttl
+++ b/models/AOP_360.ttl
@@ -1,13 +1,21 @@
 
 <https://noctua.apps.renci.org/model/AOP_360> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://id.nlm.nih.gov/mesh/D009026> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> .
+<http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "274.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "397"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -19,18 +27,78 @@
 
 <http://purl.obolibrary.org/obo/UBERON_0001002> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#chitin%20synthase%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004100> .
+<http://www.co-ode.org/ontologies/ont.owl#chitin%20synthase%20activity> <http://geneontology.org/lego/hint/layout/x> "434.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "790.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004100> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cuticle> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0001002> .
+<http://www.co-ode.org/ontologies/ont.owl#cuticle> <http://geneontology.org/lego/hint/layout/x> "110"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "786.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0001002> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0042335> .
+<http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> <http://geneontology.org/lego/hint/layout/x> "275.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "682.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0042335> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0018990> .
+<http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	<http://geneontology.org/lego/hint/layout/x> "271.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "531.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0018990> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_360> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Chitin synthase 1 inhibition leading to mortality"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Chitin synthase 1 inhibition leading to mortality"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2835 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cuticle> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2836 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chitin%20synthase%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2837 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2838 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_48.ttl b/models/AOP_48.ttl
index 3264f777..38be224b 100644
--- a/models/AOP_48.ttl
+++ b/models/AOP_48.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_48> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -35,30 +37,37 @@
 
 <http://purl.obolibrary.org/obo/GO_0006816> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> .
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://geneontology.org/lego/hint/layout/x> "133.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1794.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://purl.obolibrary.org/obo/RO_0000057> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://purl.obolibrary.org/obo/RO_0002332> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> .
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://geneontology.org/lego/hint/layout/x> "460.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1804.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0004025> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0005739> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005739> .
+<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005739> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> .
+<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://purl.obolibrary.org/obo/RO_0003303> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
+	<http://geneontology.org/lego/hint/layout/x> "471.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1389"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -68,47 +77,76 @@
 
 <http://purl.obolibrary.org/obo/MP_0002229> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#astrocyte> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> .
+<http://www.co-ode.org/ontologies/ont.owl#astrocyte> <http://geneontology.org/lego/hint/layout/x> "837.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1006"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0001015> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	<http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> .
-
-<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> .
-
-<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> .
+	<http://geneontology.org/lego/hint/layout/x> "270.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "923.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://geneontology.org/lego/hint/layout/x> "52"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1022"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0001015> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://geneontology.org/lego/hint/layout/x> "430.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "746.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004972> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0017146> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> .
+<http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "474.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2012.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> .
+	<http://geneontology.org/lego/hint/layout/x> "864.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1999"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007612> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0007613> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#learning> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> .
+<http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "589.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "283"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#memory> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> .
+<http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "257.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> .
+	<http://geneontology.org/lego/hint/layout/x> "417.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "433.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004970> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -116,4 +154,122 @@
 
 <https://noctua.apps.renci.org/model/AOP_48> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment."^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment."^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0000056> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0001015> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0004025> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> , <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	<http://geneontology.org/lego/hint/layout/x> "468"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1134"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	<http://geneontology.org/lego/hint/layout/x> "617"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "920"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t2737 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2738 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2739 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2740 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2741 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2742 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2743 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2744 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2745 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2746 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004025> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2747 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2748 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_6.ttl b/models/AOP_6.ttl
index ee645b37..6835ceda 100644
--- a/models/AOP_6.ttl
+++ b/models/AOP_6.ttl
@@ -15,23 +15,27 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/GO_0006635> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
-	<http://geneontology.org/lego/hint/layout/x> "413.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "513.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> <http://geneontology.org/lego/hint/layout/x> "137.63333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "449.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006635> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000013056> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#peroxisome%20proliferator-activated%20receptor%20alpha> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> , <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
-	<http://geneontology.org/lego/hint/layout/x> "152.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "913.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#peroxisome%20proliferator-activated%20receptor%20alpha> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
+	<http://geneontology.org/lego/hint/layout/x> "173.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "915.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000013056> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0035624> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -55,78 +59,104 @@
 
 <http://purl.obolibrary.org/obo/PR_000011048> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> <http://geneontology.org/lego/hint/layout/x> "749.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "208"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> <http://geneontology.org/lego/hint/layout/x> "548.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "177"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002118> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#ketone%20body> <http://geneontology.org/lego/hint/layout/x> "103.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "276"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#ketone%20body> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	<http://geneontology.org/lego/hint/layout/x> "862.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "397"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_73693> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#ketosis> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> , <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
-	<http://geneontology.org/lego/hint/layout/x> "453.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "296.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#ketosis> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
+	<http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
+	<http://geneontology.org/lego/hint/layout/x> "540.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "390.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D007662> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
-	<http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> ;
-	<http://geneontology.org/lego/hint/layout/x> "549.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "648.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> <http://geneontology.org/lego/hint/layout/x> "531.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "558.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> , <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0035624> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#weight%20loss> <http://geneontology.org/lego/hint/layout/x> "448"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "10"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#weight%20loss> <http://geneontology.org/lego/hint/layout/x> "63"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "32"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001263> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_6> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Antagonist binding to PPARα leading to body-weight loss"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> <http://geneontology.org/lego/hint/layout/x> "549"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "884"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> <http://geneontology.org/lego/hint/layout/x> "529"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "917"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048019> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000002> <http://geneontology.org/lego/hint/layout/x> "291"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "744"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000002> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	<http://geneontology.org/lego/hint/layout/x> "160"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "719"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000011048> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000003> <http://geneontology.org/lego/hint/layout/x> "804"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "741"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000003> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	<http://geneontology.org/lego/hint/layout/x> "839"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "723"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000011047> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> <http://geneontology.org/lego/hint/layout/x> "538"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "735"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> <http://geneontology.org/lego/hint/layout/x> "530"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "733"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003714> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> <http://geneontology.org/lego/hint/layout/x> "442"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "96"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> <http://purl.obolibrary.org/obo/RO_0000057> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> ;
+	<http://geneontology.org/lego/hint/layout/x> "547"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#weight%20loss> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0030163> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000011> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
+	<http://geneontology.org/lego/hint/layout/x> "844"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "553"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000013056> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://n2t.net/MESH:D009124> a <http://www.w3.org/2002/07/owl#Class> .
+
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> <http://geneontology.org/lego/hint/layout/x> "828"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://n2t.net/MESH:D009124> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -134,16 +164,100 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2458 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2800 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2801 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000003> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2802 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2803 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000057> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2804 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#weight%20loss> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2805 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000011> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2806 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2807 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2808 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2809 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#peroxisome%20proliferator-activated%20receptor%20alpha> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2459 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t2810 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2811 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2812 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t2813 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000002> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .