diff --git a/models/AOP_10.ttl b/models/AOP_10.ttl
index cd4f9058..650f951e 100644
--- a/models/AOP_10.ttl
+++ b/models/AOP_10.ttl
@@ -15,8 +15,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/GO_0060079> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> <http://geneontology.org/lego/hint/layout/x> "455.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -24,7 +22,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0060079> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007268> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -33,7 +31,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007268> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_17996> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -51,66 +49,66 @@
 
 <http://purl.obolibrary.org/obo/PR_000007771> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#chloride> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "153.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#chloride> <http://geneontology.org/lego/hint/layout/x> "153.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1495.2499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_17996> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> <http://geneontology.org/lego/hint/layout/x> "460.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1465.9999542236328"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0022851> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> <http://geneontology.org/lego/hint/layout/x> "665.625"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0050811> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://geneontology.org/lego/hint/layout/x> "820.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> <http://geneontology.org/lego/hint/layout/x> "820.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1746.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007766> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://geneontology.org/lego/hint/layout/x> "560.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> <http://geneontology.org/lego/hint/layout/x> "560.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1747.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007770> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
-	<http://geneontology.org/lego/hint/layout/x> "296"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> <http://geneontology.org/lego/hint/layout/x> "296"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1723.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007771> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> <http://geneontology.org/lego/hint/layout/x> "457.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "942.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#seizures> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0051899> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#seizures> <http://geneontology.org/lego/hint/layout/x> "454.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "821"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000025> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_10> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -120,6 +118,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
@@ -128,56 +128,63 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3726 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t3934 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chloride> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t3935 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3727 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t3936 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3728 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t3937 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3729 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t3938 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3730 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t3939 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3731 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t3940 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3732 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t3941 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3733 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+_:t3942 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#seizures> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_12.ttl b/models/AOP_12.ttl
index 4e008fad..2d769277 100644
--- a/models/AOP_12.ttl
+++ b/models/AOP_12.ttl
@@ -23,13 +23,13 @@
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://purl.obolibrary.org/obo/RO_0002234> <https://noctua.apps.renci.org/model/AOP_12/64ecbbe400000017> ;
 	<http://geneontology.org/lego/hint/layout/x> "2870.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "756.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -37,19 +37,19 @@
 
 <http://purl.obolibrary.org/obo/GO_0006816> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://geneontology.org/lego/hint/layout/x> "2247"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "964"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://geneontology.org/lego/hint/layout/x> "2346"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "947"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://geneontology.org/lego/hint/layout/x> "2710.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "949.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -58,7 +58,7 @@
 	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -70,22 +70,22 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#astrocyte> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "2697.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://geneontology.org/lego/hint/layout/x> "2697.4999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "321"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> , <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
 	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> .
 
-<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://geneontology.org/lego/hint/layout/x> "2330.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "356.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://geneontology.org/lego/hint/layout/x> "2214.997314453125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "357.9989547729492"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004972> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -96,14 +96,14 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	<http://geneontology.org/lego/hint/layout/x> "2413.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1111"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0046903> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -115,7 +115,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "129"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "2856"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "123"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -125,25 +125,25 @@
 
 <http://purl.obolibrary.org/obo/PR_000004716> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://geneontology.org/lego/hint/layout/x> "2168.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	<http://geneontology.org/lego/hint/layout/x> "2168.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "771"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#secretion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+<http://www.co-ode.org/ontologies/ont.owl#secretion> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://geneontology.org/lego/hint/layout/x> "2575.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "773.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_12> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -161,92 +161,108 @@
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3689 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+_:t4975 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4976 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3690 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4977 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3691 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4978 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3692 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+_:t4979 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_12/64ecbbe400000017> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3693 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+_:t4980 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4981 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4982 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3694 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+_:t4983 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3695 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4984 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3696 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4985 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3697 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4986 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3698 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4987 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3699 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4988 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3700 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_13.ttl b/models/AOP_13.ttl
index 76b6e04d..90097d60 100644
--- a/models/AOP_13.ttl
+++ b/models/AOP_13.ttl
@@ -13,8 +13,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0004024> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002410> <https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> ;
@@ -23,7 +21,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_39124> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -34,14 +32,14 @@
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://geneontology.org/lego/hint/layout/x> "543.5000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1443.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -50,7 +48,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "763.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004972> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -61,14 +59,14 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	<http://geneontology.org/lego/hint/layout/x> "906.6333160400391"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1611.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0045202> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -77,7 +75,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "771.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0045202> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0046903> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -89,22 +87,22 @@
 	<http://geneontology.org/lego/hint/layout/y> "555"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "189.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "541"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "565.6333160400391"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://geneontology.org/lego/hint/layout/x> "565.6333160400391"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "556.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000004716> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -113,16 +111,16 @@
 	<http://geneontology.org/lego/hint/layout/y> "1135.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#secretion> <http://purl.obolibrary.org/obo/RO_0002410> <https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	<http://geneontology.org/lego/hint/layout/x> "394.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1144"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_14321> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -139,41 +137,41 @@
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0030425> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
-	<http://geneontology.org/lego/hint/layout/x> "466.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> <http://geneontology.org/lego/hint/layout/x> "466.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "908.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048813> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> <http://geneontology.org/lego/hint/layout/x> "692.5000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "917.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0014047> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#glutamate%281-%29> <http://geneontology.org/lego/hint/layout/x> "1007.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "920"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_14321> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> <http://geneontology.org/lego/hint/layout/x> "562.6333160400391"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "768.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007416> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_13> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -188,13 +186,17 @@
 	<http://geneontology.org/lego/hint/layout/y> "1130"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> <http://geneontology.org/lego/hint/layout/x> "552.8833160400391"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1237"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> <http://geneontology.org/lego/hint/layout/x> "547.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1267"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0002411> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0017003> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -202,126 +204,133 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3704 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4926 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#dendrite> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3705 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4927 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3706 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t4928 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3707 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4929 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3708 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4930 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3709 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4931 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3710 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4932 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#glutamate%281-%29> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3711 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4933 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3712 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4934 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3713 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+_:t4935 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4936 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000015> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3714 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4937 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#glutamate%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3715 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4938 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_13/64ecbbe400000016> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3716 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t4939 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#dendrite%20morphogenesis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3717 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+_:t4940 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3718 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4941 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3719 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4942 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3720 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4943 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3721 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4944 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_131.ttl b/models/AOP_131.ttl
index 40fc283f..5bb13d94 100644
--- a/models/AOP_131.ttl
+++ b/models/AOP_131.ttl
@@ -19,21 +19,24 @@
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
+<http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0002332> <http://www.co-ode.org/ontologies/ont.owl#porphyrins> ;
 	<http://geneontology.org/lego/hint/layout/x> "454.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "695.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A2> , <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A5%20%28chicken%29> ;
+	<http://purl.obolibrary.org/obo/RO_0002332> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
+	<http://geneontology.org/lego/hint/layout/x> "467.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1229"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -52,14 +55,14 @@
 	<http://geneontology.org/lego/hint/layout/y> "1513.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003858> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "464"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1506.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004874> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_26214> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -73,15 +76,13 @@
 
 <http://purl.obolibrary.org/obo/PR_P79761> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A2> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "143.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A2> <http://geneontology.org/lego/hint/layout/x> "143.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1295.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006102> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A5%20%28chicken%29> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "832.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A5%20%28chicken%29> <http://geneontology.org/lego/hint/layout/x> "832.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1289.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_P79761> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -91,34 +92,34 @@
 	<http://geneontology.org/lego/hint/layout/y> "197"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005654> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#porphyrins> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#porphyria> ;
+<http://www.co-ode.org/ontologies/ont.owl#porphyrins> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#porphyria> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "416.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_26214> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> <http://geneontology.org/lego/hint/layout/x> "453.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> <http://geneontology.org/lego/hint/layout/x> "452.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "996.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_27258> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen%20decarboxylase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	<http://geneontology.org/lego/hint/layout/x> "831.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "682.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000017134> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_131> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_131> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Aryl hydrocarbon receptor activation leading to uroporphyria"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -134,30 +135,51 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3185 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5079 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#porphyrins> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#porphyria> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5080 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3186 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t5081 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3187 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5082 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3188 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+_:t5083 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A2> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5084 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cytochrome%20P450%201A5%20%28chicken%29> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5085 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002332> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#uroporphyrinogen> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_15.ttl b/models/AOP_15.ttl
index 75525ce4..abef89fa 100644
--- a/models/AOP_15.ttl
+++ b/models/AOP_15.ttl
@@ -13,9 +13,9 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -25,11 +25,12 @@
 
 <http://purl.obolibrary.org/obo/GO_0006305> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> <http://geneontology.org/lego/hint/layout/x> "106"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "350.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+	<http://geneontology.org/lego/hint/layout/x> "64"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "352.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16991> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://geneontology.org/lego/hint/layout/x> "488.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -37,31 +38,30 @@
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006305> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
-	<http://geneontology.org/lego/hint/layout/x> "484.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "365.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+	<http://geneontology.org/lego/hint/layout/x> "501.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "355.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019002> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006281> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D009154> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mutation> <http://purl.obolibrary.org/obo/RO_0000057> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
-	<http://geneontology.org/lego/hint/layout/x> "482.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "124"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mutation> <http://geneontology.org/lego/hint/layout/x> "483.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "105"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009154> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_15> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_15> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://www.w3.org/2002/07/owl#versionIRI> <https://noctua.apps.renci.org/model/AOP_15> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -69,43 +69,45 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0019002> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3079 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000057> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3080 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4121 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3081 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t4122 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20alkylation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3082 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4123 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-09-05"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3083 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t4124 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019002> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-05"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4125 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_150.ttl b/models/AOP_150.ttl
index b824e329..e75c7552 100644
--- a/models/AOP_150.ttl
+++ b/models/AOP_150.ttl
@@ -23,7 +23,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "193"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -35,13 +35,12 @@
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> ;
-	<http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
+<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
 	<http://geneontology.org/lego/hint/layout/x> "658.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "990.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002234> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -59,28 +58,28 @@
 	<http://purl.obolibrary.org/obo/RO_0002352> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003858> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "619.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1543.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> <http://geneontology.org/lego/hint/layout/x> "609.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1549.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004874> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20nuclear%20translocator> <http://geneontology.org/lego/hint/layout/x> "1004.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1359.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002352> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004303> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> <http://geneontology.org/lego/hint/layout/x> "660.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1165"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046983> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0072358> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -91,31 +90,31 @@
 <http://purl.obolibrary.org/obo/UBERON_0004535> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#mortality> , <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
-	<http://geneontology.org/lego/hint/layout/x> "871.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "448.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "819.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "394.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001544> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> <http://geneontology.org/lego/hint/layout/x> "189.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
+	<http://geneontology.org/lego/hint/layout/x> "189.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "343.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0004535> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#mortality> , <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
 	<http://geneontology.org/lego/hint/layout/x> "473.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "471.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002296> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0072358> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> <http://geneontology.org/lego/hint/layout/x> "489.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "194"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0008762> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000008555> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -124,7 +123,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000008555> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003158> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -132,33 +131,34 @@
 
 <http://purl.obolibrary.org/obo/PR_000017284> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "659.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "802.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
+	<http://geneontology.org/lego/hint/layout/x> "665.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "826.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0008469> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
-	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "643.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> <http://geneontology.org/lego/hint/layout/x> "643.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "615.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019002> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003158> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	<http://geneontology.org/lego/hint/layout/x> "305.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "820"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000017284> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_150> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_150> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-8688-6599"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -168,14 +168,12 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002296> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> <http://geneontology.org/lego/hint/layout/x> "650.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1366"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046983> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -186,127 +184,131 @@
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
+<http://purl.obolibrary.org/obo/RO_0019002> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002411> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3161 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4890 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3162 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t4891 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3163 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
+_:t4892 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019002> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3164 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+_:t4893 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3165 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4894 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3166 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4895 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3167 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+_:t4896 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20A> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3168 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4897 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3169 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4898 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000010> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20dimerization%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3170 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4899 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004021> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20protein%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4900 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3171 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4901 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3172 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4902 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3173 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4903 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aryl%20hydrocarbon%20receptor%20nuclear%20translocator> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_150/64ecbbe400000006> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3174 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002296> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> ;
+_:t4904 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-8688-6599"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3175 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4905 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3176 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4906 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cardiovascular%20system%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#embryonic%20lethality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3177 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20cardiovascular%20system%20physiology> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_154.ttl b/models/AOP_154.ttl
index bece4d56..f5980252 100644
--- a/models/AOP_154.ttl
+++ b/models/AOP_154.ttl
@@ -1,8 +1,6 @@
 
 <https://noctua.apps.renci.org/model/AOP_154> a <http://www.w3.org/2002/07/owl#Ontology> .
 
-<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -19,19 +17,19 @@
 
 <http://purl.obolibrary.org/obo/PR_000001391> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#interleukin-4> <http://geneontology.org/lego/hint/layout/x> "18"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "732.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
+<http://www.co-ode.org/ontologies/ont.owl#interleukin-4> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
+	<http://geneontology.org/lego/hint/layout/x> "17"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "777.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000001391> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> <http://geneontology.org/lego/hint/layout/x> "242.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "644.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#Immunosuppression> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_154/64ecbbe400000028> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0032633> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0001775> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -42,23 +40,23 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005488> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20activation> <http://geneontology.org/lego/hint/layout/x> "173.49998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "917.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cell%20activation> <http://geneontology.org/lego/hint/layout/x> "337.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "923.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> , <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0001775> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0002534> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "458.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "884.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "632.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "902.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> , <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002534> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D007165> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -78,65 +76,58 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#FK506-binding%20protein%2015> <http://geneontology.org/lego/hint/layout/x> "722.4999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1397.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007535> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#FKBP12%20%28Arabidopsis%20thaliana%29> <http://geneontology.org/lego/hint/layout/x> "209.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1385.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
+<http://www.co-ode.org/ontologies/ont.owl#FKBP12%20%28Arabidopsis%20thaliana%29> <http://geneontology.org/lego/hint/layout/x> "179.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1414.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/TAIR_AT5G64350> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> <http://geneontology.org/lego/hint/layout/x> "467.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1139.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> <http://geneontology.org/lego/hint/layout/x> "473.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1122.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MI_0254> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-<http://www.co-ode.org/ontologies/ont.owl#Immunosuppression> <http://geneontology.org/lego/hint/layout/x> "477.63331604003906"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "438"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D007165> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#interleukin-2> <http://geneontology.org/lego/hint/layout/x> "929.2499542236328"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "738.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
+<http://www.co-ode.org/ontologies/ont.owl#interleukin-2> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
+	<http://geneontology.org/lego/hint/layout/x> "1053.2423248291016"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "740.4848022460938"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000001379> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> <http://geneontology.org/lego/hint/layout/x> "738.5000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "655.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#Immunosuppression> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_154/64ecbbe400000028> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0032623> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#NFAT%20activation%20molecule%201> <http://geneontology.org/lego/hint/layout/x> "879.5000457763672"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "927.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
+<http://www.co-ode.org/ontologies/ont.owl#NFAT%20activation%20molecule%201> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
+	<http://geneontology.org/lego/hint/layout/x> "972.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "916.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000011161> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#NFAT%20protein> <http://geneontology.org/lego/hint/layout/x> "180.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1217"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
+<http://www.co-ode.org/ontologies/ont.owl#NFAT%20protein> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
+	<http://geneontology.org/lego/hint/layout/x> "49.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1121"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000003112> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_154> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	a <http://www.w3.org/2002/07/owl#Ontology> ;
+<https://noctua.apps.renci.org/model/AOP_154> a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -146,7 +137,15 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/GO_0006955> a <http://www.w3.org/2002/07/owl#Class> .
+
+<https://noctua.apps.renci.org/model/AOP_154/64ecbbe400000028> <http://geneontology.org/lego/hint/layout/x> "474.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "471"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006955> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -154,105 +153,105 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3377 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5048 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3378 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5049 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3379 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5050 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3380 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5051 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3381 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5052 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3382 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5053 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Immunosuppression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_154/64ecbbe400000028> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3383 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5054 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Immunosuppression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_154/64ecbbe400000028> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3384 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5055 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3385 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5056 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3386 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5057 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#FK506-binding%20protein%2015> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3387 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5058 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#FKBP12%20%28Arabidopsis%20thaliana%29> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3388 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5059 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NFAT%20protein> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#genetic%20interference> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3389 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5060 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NFAT%20activation%20molecule%201> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3390 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5061 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-2%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3391 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5062 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#interleukin-4%20production> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_155.ttl b/models/AOP_155.ttl
index cb6f05ae..4138723f 100644
--- a/models/AOP_155.ttl
+++ b/models/AOP_155.ttl
@@ -19,12 +19,12 @@
 
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "164.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "164.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "206.24998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -39,15 +39,14 @@
 <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "335.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "76"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://geneontology.org/lego/hint/layout/x> "201.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "740.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -55,12 +54,12 @@
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "757"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://geneontology.org/lego/hint/layout/x> "757"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "71.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000006481> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -68,55 +67,56 @@
 	<http://geneontology.org/lego/hint/layout/x> "603.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "731.4999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006481> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	<http://geneontology.org/lego/hint/layout/x> "454.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "454.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "312.49998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "845"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "574.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "779"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "571.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://geneontology.org/lego/hint/layout/x> "448"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "564.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "352"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "564"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "175.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "432.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "100.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "421.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/UBERON_2001278> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "597.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "411"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001278> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_155> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_155> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -126,11 +126,9 @@
 
 <http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
-<http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -138,42 +136,56 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3449 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
+_:t4852 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3450 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+_:t4853 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4854 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004021> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4855 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3451 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4856 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3452 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+_:t4857 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3453 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4858 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3454 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4859 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#type%20II%20iodothyronine%20deiodinase> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_156.ttl b/models/AOP_156.ttl
index 001250c3..18411ac4 100644
--- a/models/AOP_156.ttl
+++ b/models/AOP_156.ttl
@@ -17,16 +17,14 @@
 
 <http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002566> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "408.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "408.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "166.24998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -38,18 +36,18 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "265.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "67"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "269.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "35"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0002566> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://geneontology.org/lego/hint/layout/x> "315.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "595.2500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://geneontology.org/lego/hint/layout/x> "321.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "668.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -57,44 +55,44 @@
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "702"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://geneontology.org/lego/hint/layout/x> "702"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "69.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000006481> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#type%20II%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "622.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "582.5000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "625.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "663.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006481> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	<http://geneontology.org/lego/hint/layout/x> "246.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "246.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "269.49998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "659"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "502.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "577"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "512.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://geneontology.org/lego/hint/layout/x> "223.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "491"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "115.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "532"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -102,23 +100,23 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "23"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "377.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001277> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "414.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "394.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_156> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_156> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -126,7 +124,11 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -134,49 +136,63 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3473 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4312 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4313 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3474 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t4314 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3475 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4315 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3476 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+_:t4316 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4317 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-10"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3477 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4318 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3478 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4319 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3479 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4320 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#type%20II%20iodothyronine%20deiodinase> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_157.ttl b/models/AOP_157.ttl
index 8b046a06..abffce71 100644
--- a/models/AOP_157.ttl
+++ b/models/AOP_157.ttl
@@ -19,12 +19,12 @@
 
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "348.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "348.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "199.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -39,15 +39,15 @@
 <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "163.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "101"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://geneontology.org/lego/hint/layout/x> "324.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "632.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://geneontology.org/lego/hint/layout/x> "316.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "732.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -56,43 +56,43 @@
 <http://purl.obolibrary.org/obo/PR_000006480> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "638.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "622.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "664.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "715.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "614"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://geneontology.org/lego/hint/layout/x> "614"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "107.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	<http://geneontology.org/lego/hint/layout/x> "141.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "141.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "286.49998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "566"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "548.2500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://geneontology.org/lego/hint/layout/x> "157"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "532.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "99"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "563.9833374023438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -100,23 +100,23 @@
 	<http://geneontology.org/lego/hint/layout/y> "406.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/UBERON_2001278> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "686.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "686.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "399.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001278> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_157> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_157> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation "^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -124,7 +124,11 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -132,28 +136,49 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2926 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5064 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5065 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2927 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5066 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5067 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-10"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5068 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-13"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2928 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5069 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#posterior%20chamber%20swim%20bladder> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2929 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5070 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_158.ttl b/models/AOP_158.ttl
index bb3486ce..b4e7d635 100644
--- a/models/AOP_158.ttl
+++ b/models/AOP_158.ttl
@@ -19,12 +19,12 @@
 
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003824> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -39,15 +39,14 @@
 <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://geneontology.org/lego/hint/layout/x> "750.7350158691406"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1620.2483520507812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> <http://geneontology.org/lego/hint/layout/x> "695.7333374023438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1410.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003824> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -55,82 +54,147 @@
 
 <http://purl.obolibrary.org/obo/PR_000006480> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "747.8749694824219"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1923.4998168945312"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	<http://geneontology.org/lego/hint/layout/x> "726.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1602.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006480> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
-	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
-	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "172"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1413.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	<http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://geneontology.org/lego/hint/layout/x> "458.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1245"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0004009> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/UBERON_2001277> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001277> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
-	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "993.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_158> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_158> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0004009> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2610 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t4998 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4999 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5000 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004021> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5001 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-10"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5002 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5003 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5004 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5005 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-10"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5006 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#type%20I%20iodothyronine%20deiodinase> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#catalytic%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-10"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_159.ttl b/models/AOP_159.ttl
index 0b82d5b0..e33d0a54 100644
--- a/models/AOP_159.ttl
+++ b/models/AOP_159.ttl
@@ -21,10 +21,10 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "516.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "649.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PCO_0000008> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -36,11 +36,11 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "376.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "535"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "348.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "490"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_30660> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -51,32 +51,32 @@
 <http://purl.obolibrary.org/obo/MP_0005475> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+	<http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	<http://geneontology.org/lego/hint/layout/x> "225"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1188.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0004009> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005475> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	<http://geneontology.org/lego/hint/layout/x> "722.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1418.7500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_60311> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://geneontology.org/lego/hint/layout/x> "373.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1407.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://geneontology.org/lego/hint/layout/x> "360.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1388.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006590> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "88"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1299.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "54"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1389.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_28774> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -84,53 +84,53 @@
 
 <http://purl.obolibrary.org/obo/PCO_0000001> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "557"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "450.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://geneontology.org/lego/hint/layout/x> "706"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "453.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/NBO_0000371> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "333.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "754.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
+<http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> <http://geneontology.org/lego/hint/layout/x> "327.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "792.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017004> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/NBO_0000371> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004447> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/PR_000016584> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "869.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1278.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+<http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> <http://geneontology.org/lego/hint/layout/x> "630.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1327.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_28774> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	<http://geneontology.org/lego/hint/layout/x> "617.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1186"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005418> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#iodide%20peroxidase%20activity> <http://geneontology.org/lego/hint/layout/x> "366"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1572.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004447> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#thyroid%20peroxidase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#iodide%20peroxidase%20activity> ;
 	<http://geneontology.org/lego/hint/layout/x> "713.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1581.0000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000016584> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0048798> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -138,7 +138,6 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> <http://geneontology.org/lego/hint/layout/x> "67"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1059"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_2001277> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
@@ -146,15 +145,16 @@
 <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> <http://geneontology.org/lego/hint/layout/x> "399.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1003.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048798> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_159> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_159> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -162,11 +162,13 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0017004> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0003304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0004009> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -174,58 +176,65 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3243 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4737 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3244 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+_:t4738 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3245 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#3%2C3%27%2C5%27-triiodothyronine> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20hormone%20level> ;
+_:t4739 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3246 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+_:t4740 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004021> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3247 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4741 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017004> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3248 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4742 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20peroxidase%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3249 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4743 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4744 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#anterior%20chamber%20swim%20bladder> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3250 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+_:t4745 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#swim%20bladder%20inflation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#aquatic%20locomotion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_17.ttl b/models/AOP_17.ttl
index 70d12309..bafe2d6b 100644
--- a/models/AOP_17.ttl
+++ b/models/AOP_17.ttl
@@ -7,8 +7,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002566> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -19,14 +17,14 @@
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
-	<http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+<http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://geneontology.org/lego/hint/layout/x> "471.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1221.500015258789"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -38,20 +36,20 @@
 	<http://geneontology.org/lego/hint/layout/y> "1158"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://geneontology.org/lego/hint/layout/x> "198.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1014.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> , <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://geneontology.org/lego/hint/layout/x> "53.633331298828125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "881"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0002526> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -71,28 +69,28 @@
 	<http://geneontology.org/lego/hint/layout/y> "625.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "277.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "623.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002566> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "473.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://geneontology.org/lego/hint/layout/x> "473.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "846.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_17> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -102,71 +100,73 @@
 
 <http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<https://noctua.apps.renci.org/model/AOP_17/64ecbbe400000014> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
-	<http://geneontology.org/lego/hint/layout/x> "473"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_17/64ecbbe400000014> <http://geneontology.org/lego/hint/layout/x> "473"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1354"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002526> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
+<http://purl.obolibrary.org/obo/RO_0002411> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3734 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
+_:t5109 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3735 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
+_:t5110 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3736 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5111 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3737 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t5112 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3738 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+_:t5113 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3739 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+_:t5114 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3740 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+_:t5115 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3741 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+_:t5116 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_17/64ecbbe400000014> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_202.ttl b/models/AOP_202.ttl
index 4d449bbb..c534618a 100644
--- a/models/AOP_202.ttl
+++ b/models/AOP_202.ttl
@@ -14,7 +14,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "133"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0061505> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#Translocation%2C%20Genetic> <http://geneontology.org/lego/hint/layout/x> "679"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "138"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -26,7 +26,7 @@
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Inhibitor binding to topoisomerase II leading to infant leukaemia"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -38,7 +38,7 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2465 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4247 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20topoisomerase%20II%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Translocation%2C%20Genetic> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_212.ttl b/models/AOP_212.ttl
index 5216660f..d2bb644a 100644
--- a/models/AOP_212.ttl
+++ b/models/AOP_212.ttl
@@ -27,12 +27,12 @@
 
 <http://purl.obolibrary.org/obo/GO_0006915> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#apoptotic%20process> <http://geneontology.org/lego/hint/layout/x> "491.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "465.50001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#apoptotic%20process> <http://geneontology.org/lego/hint/layout/x> "497.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "451.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0011003> <http://www.co-ode.org/ontologies/ont.owl#spermatocyte> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006915> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004857> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -42,15 +42,15 @@
 	<http://geneontology.org/lego/hint/layout/y> "955.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004857> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#histone%20deacetylase%201> <http://geneontology.org/lego/hint/layout/x> "894.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "962.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#enzyme%20inhibitor%20activity> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#enzyme%20inhibitor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000008478> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_15358> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -58,17 +58,17 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#histone> <http://geneontology.org/lego/hint/layout/x> "117.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "783.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_15358> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20cell%20cycle> ;
+	<http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#histone> ;
 	<http://geneontology.org/lego/hint/layout/x> "512.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "770"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0031399> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000017> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -84,41 +84,42 @@
 	<http://geneontology.org/lego/hint/layout/x> "109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "598.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000029191> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20cell%20cycle> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#apoptotic%20process> ;
 	<http://geneontology.org/lego/hint/layout/x> "498.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "602.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0051726> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#spermatocyte> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
 	<http://geneontology.org/lego/hint/layout/x> "498.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "308.24998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000017> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> <http://geneontology.org/lego/hint/layout/x> "499.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "205"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> <http://geneontology.org/lego/hint/layout/x> "497.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "113"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0004020> <http://www.co-ode.org/ontologies/ont.owl#Testis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/HP_0000029> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#Testis> <http://geneontology.org/lego/hint/layout/x> "109.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "195.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
+<http://www.co-ode.org/ontologies/ont.owl#Testis> <http://geneontology.org/lego/hint/layout/x> "36"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "125.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/FMA_7210> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_212> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_212> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Histone deacetylase inhibition leading to testicular atrophy"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -126,61 +127,70 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0011003> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0004020> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3412 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5123 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#Testis> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3413 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#histone> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3414 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+_:t5124 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#spermatocyte> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3415 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0011003> ;
+_:t5125 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004020> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#Testicular%20atrophy> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Testis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5126 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0011003> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#apoptotic%20process> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#spermatocyte> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3416 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t5127 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20cycle-related%20cyclin> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20cell%20cycle> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3417 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t5128 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#enzyme%20inhibitor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3418 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t5129 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#histone%20deacetylase%201> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#enzyme%20inhibitor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5130 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20protein%20modification%20process> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#histone> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-15"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_220.ttl b/models/AOP_220.ttl
index 6976850a..5d0f17bc 100644
--- a/models/AOP_220.ttl
+++ b/models/AOP_220.ttl
@@ -1,12 +1,20 @@
 
 <https://noctua.apps.renci.org/model/AOP_220> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002410> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/CL_0000235> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://www.co-ode.org/ontologies/ont.owl#macrophage> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#macrophage%20activation%20involved%20in%20immune%20response> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000235> .
+	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000235> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -22,20 +30,64 @@
 
 <http://purl.obolibrary.org/obo/PR_000017294> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cellular%20response%20to%20oxidative%20stress> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0034599> .
+<http://www.co-ode.org/ontologies/ont.owl#cellular%20response%20to%20oxidative%20stress> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0034599> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#hypoxia> <http://geneontology.org/lego/hint/layout/x> "862.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005039> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
+	<http://geneontology.org/lego/hint/layout/x> "873.4998931884766"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "337.2499771118164"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000008555> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#macrophage%20activation%20involved%20in%20immune%20response> <http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002281> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://www.co-ode.org/ontologies/ont.owl#von%20Hippel-Lindau%20disease%20tumor%20suppressor> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
+	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000017294> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#hypoxia> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005039> .
+<https://noctua.apps.renci.org/model/AOP_220> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#Ontology> ;
+	<http://purl.org/dc/elements/1.1/title> "Cyp2E1 Activation Leading to Liver Cancer"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000008555> .
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#macrophage%20activation%20involved%20in%20immune%20response> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002281> .
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#von%20Hippel-Lindau%20disease%20tumor%20suppressor> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000017294> .
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<https://noctua.apps.renci.org/model/AOP_220> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Cyp2E1 Activation Leading to Liver Cancer"^^<http://www.w3.org/2001/XMLSchema#string> .
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t4052 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hypoxia-inducible%20factor%201-alpha> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4053 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#von%20Hippel-Lindau%20disease%20tumor%20suppressor> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hypoxia> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_23.ttl b/models/AOP_23.ttl
index 386e4ffc..96209690 100644
--- a/models/AOP_23.ttl
+++ b/models/AOP_23.ttl
@@ -32,36 +32,36 @@
 	<http://geneontology.org/lego/hint/layout/y> "2770.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004191> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#testosterone> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
 	<http://geneontology.org/lego/hint/layout/x> "883.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2228"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_17347> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2218.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0061370> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
 	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -89,69 +89,68 @@
 
 <http://purl.obolibrary.org/obo/VT_1000294> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
+<http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16469> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	<http://geneontology.org/lego/hint/layout/x> "665.625"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/VT_1000294> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1912.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> <http://purl.obolibrary.org/obo/RO_0002332> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
+	<http://geneontology.org/lego/hint/layout/x> "482.7499694824219"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1918.4998168945312"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006703> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "862.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048599> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0001555> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "94.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "94.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "72.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+<http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
 	<http://geneontology.org/lego/hint/layout/x> "668.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1290"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0009306> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006898> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#vitellogenins> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> , <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> , <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "993.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#vitellogenins> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> , <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> , <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> ;
+	<http://geneontology.org/lego/hint/layout/x> "472.7499694824219"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "954.7498779296875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D014819> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004882> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -160,7 +159,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "2763.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004882> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_81568> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -178,13 +177,13 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_81568> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_23> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_23> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -192,64 +191,108 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3092 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+_:t4107 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#testosterone> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4108 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002332> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4109 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4110 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4111 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4112 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3093 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4113 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4114 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4115 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4116 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4117 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3094 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4118 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#Follicle%20stimulating%20hormone> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3095 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4119 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#Luteinizing%20hormone> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3096 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4120 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#androgen%20receptor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#androgen%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3097 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3098 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3099 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#testosterone%20biosynthetic%20process> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_25.ttl b/models/AOP_25.ttl
index dfe120e6..fb65b374 100644
--- a/models/AOP_25.ttl
+++ b/models/AOP_25.ttl
@@ -13,6 +13,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/PCO_0000008> a <http://www.w3.org/2002/07/owl#Class> .
@@ -23,10 +25,9 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000008> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -34,8 +35,8 @@
 	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1300"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -67,63 +68,64 @@
 	<http://geneontology.org/lego/hint/layout/x> "509.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1716.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16469> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://geneontology.org/lego/hint/layout/x> "665.625"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> <http://geneontology.org/lego/hint/layout/x> "665.625"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/VT_1000294> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> <http://purl.obolibrary.org/obo/RO_0002332> <http://www.co-ode.org/ontologies/ont.owl#17beta-estradiol> ;
 	<http://geneontology.org/lego/hint/layout/x> "460.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2133.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006703> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "862.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048599> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0001555> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://geneontology.org/lego/hint/layout/x> "146.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	<http://geneontology.org/lego/hint/layout/x> "146.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "263.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PCO_0000001> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#protein%20secretion> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> ;
 	<http://geneontology.org/lego/hint/layout/x> "673.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1303"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0009306> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
 	<http://geneontology.org/lego/hint/layout/x> "75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006898> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vitellogenins> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#oocyte%20development> , <http://www.co-ode.org/ontologies/ont.owl#oocyte%20growth> , <http://www.co-ode.org/ontologies/ont.owl#receptor-mediated%20endocytosis> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "993.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D014819> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0070330> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -133,21 +135,21 @@
 	<http://geneontology.org/lego/hint/layout/x> "767.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2535"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000006100> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#aromatase%20activity> <http://geneontology.org/lego/hint/layout/x> "441.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2529.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0070330> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_25> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_25> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Aromatase inhibition leading to reproductive dysfunction"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -155,22 +157,31 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2484 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4285 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#aromatase%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#estrogen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2485 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+_:t4286 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#egg%20quantity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-11"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4287 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#population%20of%20organisms> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#population%20growth%20rate> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_263.ttl b/models/AOP_263.ttl
index b6ccebc5..58d4ebf4 100644
--- a/models/AOP_263.ttl
+++ b/models/AOP_263.ttl
@@ -18,9 +18,10 @@
 <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#growth> ;
 	<http://geneontology.org/lego/hint/layout/x> "472.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "448.25001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0004009> <http://www.co-ode.org/ontologies/ont.owl#cell> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008283> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_15422> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -30,26 +31,25 @@
 
 <http://purl.obolibrary.org/obo/GO_0005739> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#ATP> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
-	<http://geneontology.org/lego/hint/layout/x> "930.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "777.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#ATP> <http://geneontology.org/lego/hint/layout/x> "836.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "702.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_15422> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> <http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "687.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
+	<http://purl.obolibrary.org/obo/RO_0004008> <http://www.co-ode.org/ontologies/ont.owl#ATP> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006754> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://geneontology.org/lego/hint/layout/x> "511.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1034"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0001015> <http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> , <http://www.co-ode.org/ontologies/ont.owl#proton%20binding> , <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> ;
+<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://geneontology.org/lego/hint/layout/x> "503.6299133300781"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1315.9842224121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005739> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0040007> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -58,15 +58,15 @@
 <http://www.co-ode.org/ontologies/ont.owl#growth> <http://geneontology.org/lego/hint/layout/x> "119.63333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "459.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0040007> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#multicellular%20organism> <http://geneontology.org/lego/hint/layout/x> "198.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "651.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#growth> ;
+	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#growth> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0000468> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0005623> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -74,39 +74,41 @@
 
 <http://purl.obolibrary.org/obo/GO_1901691> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell> <http://geneontology.org/lego/hint/layout/x> "916.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "474.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
+<http://www.co-ode.org/ontologies/ont.owl#cell> <http://geneontology.org/lego/hint/layout/x> "477.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "301.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005623> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> <http://geneontology.org/lego/hint/layout/x> "223"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "892.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> <http://geneontology.org/lego/hint/layout/x> "231.99359130859375"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1020.7378540039062"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017077> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#proton%20binding> <http://geneontology.org/lego/hint/layout/x> "512.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "901.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#proton%20binding> <http://geneontology.org/lego/hint/layout/x> "500.7485046386719"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1026.7399597167969"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_1901691> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> <http://geneontology.org/lego/hint/layout/x> "801.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "896.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> <http://geneontology.org/lego/hint/layout/x> "775.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1037.7333374023438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0051881> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_263> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_263> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -116,9 +118,13 @@
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0001015> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0004009> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0004008> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -126,65 +132,72 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3207 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell> ;
+_:t4763 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3208 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t3209 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#proton%20binding> ;
+_:t4764 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3210 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> ;
+_:t4765 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004008> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ATP> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3211 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
+_:t4766 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3212 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4767 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#multicellular%20organism> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#growth> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4768 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3213 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4769 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#oxidative%20phosphorylation%20uncoupler%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3214 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4770 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#proton%20binding> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4771 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#proton%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3215 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4772 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20mitochondrial%20membrane%20potential> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ATP%20biosynthetic%20process> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_277.ttl b/models/AOP_277.ttl
index 410fc4d4..b0a530f9 100644
--- a/models/AOP_277.ttl
+++ b/models/AOP_277.ttl
@@ -1,6 +1,8 @@
 
 <https://noctua.apps.renci.org/model/AOP_277> a <http://www.w3.org/2002/07/owl#Ontology> .
 
+<http://geneontology.org/lego/modelstate> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002331> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -13,14 +15,38 @@
 
 <http://purl.obolibrary.org/obo/PR_000001753> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase/NF-kappaB%20signaling> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007249> .
+<http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase/NF-kappaB%20signaling> <http://geneontology.org/lego/hint/layout/x> "86"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "165"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007249> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#transcription%20factor%20NF-kappa-B%20subunit> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase%2FNF-kappaB%20signaling> ;
-	<http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase%2FNF-kappaB%20signaling> ;
-	<http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase%2FNF-kappaB%20signaling> ;
-	<http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase%2FNF-kappaB%20signaling> ;
-	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000001753> .
+<http://www.co-ode.org/ontologies/ont.owl#transcription%20factor%20NF-kappa-B%20subunit> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase/NF-kappaB%20signaling> ;
+	<http://geneontology.org/lego/hint/layout/x> "271.875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000001753> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_277> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_277> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
-	<http://purl.org/dc/elements/1.1/title> "Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/title> "Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+<http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
+
+_:t4358 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#transcription%20factor%20NF-kappa-B%20subunit> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#I-kappaB%20kinase/NF-kappaB%20signaling> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_296.ttl b/models/AOP_296.ttl
index 98fe39ca..105f5e98 100644
--- a/models/AOP_296.ttl
+++ b/models/AOP_296.ttl
@@ -15,66 +15,66 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#reactive%20oxygen%20species> <http://geneontology.org/lego/hint/layout/x> "931.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "408.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> ;
+<http://www.co-ode.org/ontologies/ont.owl#reactive%20oxygen%20species> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> ;
+	<http://geneontology.org/lego/hint/layout/x> "780.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "453.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_26523> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/CHEBI_16991> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0006281> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> <http://geneontology.org/lego/hint/layout/x> "224.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "124.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002463> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> , <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+<http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> <http://purl.obolibrary.org/obo/RO_0000053> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+	<http://geneontology.org/lego/hint/layout/x> "118"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "122.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16991> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> <http://geneontology.org/lego/hint/layout/x> "461"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "208"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002296> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
+<http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> <http://geneontology.org/lego/hint/layout/x> "416"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "244"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0019002> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006281> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D009154> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#mutation> <http://geneontology.org/lego/hint/layout/x> "474.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "7"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009154> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_1901031> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
-	<http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "381.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> <http://geneontology.org/lego/hint/layout/x> "435.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "439.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_1901031> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_296> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_296> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Oxidative DNA damage leading to chromosomal aberrations and mutations"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002296> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002463> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0019002> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -82,37 +82,37 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3284 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002296> ;
+_:t4683 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019002> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3285 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002463> ;
+_:t4684 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000053> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mutation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3286 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002463> ;
+_:t4685 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#deoxyribonucleic%20acid> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3287 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4686 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#reactive%20oxygen%20species> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3288 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4687 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20response%20to%20reactive%20oxygen%20species> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#DNA%20repair> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_3.ttl b/models/AOP_3.ttl
index 71e417b2..1f2543ed 100644
--- a/models/AOP_3.ttl
+++ b/models/AOP_3.ttl
@@ -21,6 +21,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -29,21 +31,21 @@
 
 <http://purl.obolibrary.org/obo/RO_0002332> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#protein> <http://geneontology.org/lego/hint/layout/x> "56.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "741.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
+<http://www.co-ode.org/ontologies/ont.owl#protein> <http://geneontology.org/lego/hint/layout/x> "123.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "752.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_36080> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0005739> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
-	<http://geneontology.org/lego/hint/layout/x> "417"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "937.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002331> <https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> ;
+	<http://geneontology.org/lego/hint/layout/x> "891.9623107910156"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "943.7144165039062"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005739> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D057165> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -59,22 +61,22 @@
 	<http://geneontology.org/lego/hint/layout/x> "714.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1118.2500610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000031316> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#NADH%20dehydrogenase%20%28ubiquinone%29%20activity> <http://purl.obolibrary.org/obo/RO_0002428> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+<http://www.co-ode.org/ontologies/ont.owl#NADH%20dehydrogenase%20%28ubiquinone%29%20activity> <http://purl.obolibrary.org/obo/RO_0002428> <https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> ;
 	<http://geneontology.org/lego/hint/layout/x> "329.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1112"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008137> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> <http://geneontology.org/lego/hint/layout/x> "437.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "740.5000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D057165> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -86,105 +88,126 @@
 	<http://geneontology.org/lego/hint/layout/x> "702.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "725.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://geneontology.org/lego/hint/layout/x> "831.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "532.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://geneontology.org/lego/hint/layout/x> "946.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "724.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://id.nlm.nih.gov/mesh/D020734> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/MP_0003244> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> <http://purl.obolibrary.org/obo/RO_0000052> <http://www.co-ode.org/ontologies/ont.owl#Parkinsonian%20disorders> ;
-	<http://geneontology.org/lego/hint/layout/x> "441.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> <http://geneontology.org/lego/hint/layout/x> "441.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "489.24998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#Parkinsonian%20disorders> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0003244> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#Parkinsonian%20disorders> <http://geneontology.org/lego/hint/layout/x> "432.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "331"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D020734> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_3> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_3> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0003304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002503> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
+	<http://geneontology.org/lego/hint/layout/x> "446.7364196777344"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "927.9835357666016"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006120> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3346 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+_:t4843 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3347 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+_:t4844 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3348 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4845 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3349 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
+_:t4846 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002428> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NADH%20dehydrogenase%20%28ubiquinone%29%20activity> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-23"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3350 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4847 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3351 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4848 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3352 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+_:t4849 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#loss%20of%20dopaminergic%20neurons> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Parkinsonian%20disorders> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4850 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4851 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019000> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_3/64ecbbe400000021> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#Proteostasis%20deficiencies> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_360.ttl b/models/AOP_360.ttl
index eb02dbe5..1adb05e5 100644
--- a/models/AOP_360.ttl
+++ b/models/AOP_360.ttl
@@ -7,13 +7,15 @@
 
 <http://purl.obolibrary.org/obo/RO_0002327> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0002353> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://id.nlm.nih.gov/mesh/D009026> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#mortality> <http://geneontology.org/lego/hint/layout/x> "274.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "397"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D009026> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -30,34 +32,34 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004100> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cuticle> <http://geneontology.org/lego/hint/layout/x> "50"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cuticle> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
+	<http://geneontology.org/lego/hint/layout/x> "50"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "824.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0001002> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> <http://geneontology.org/lego/hint/layout/x> "275.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "682.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0042335> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> <http://geneontology.org/lego/hint/layout/x> "271.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "531.2499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0019002> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0018990> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_360> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Chitin synthase 1 inhibition leading to mortality"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -65,8 +67,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0019002> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
@@ -75,28 +75,28 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3722 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t3977 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cuticle> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3723 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t3978 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chitin%20synthase%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3724 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t3979 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cuticle%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-19"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3725 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019002> ;
+_:t3980 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019002> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ecdysis%2C%20chitin-based%20cuticle> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mortality> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_38.ttl b/models/AOP_38.ttl
index 5bf6607f..ca2f749d 100644
--- a/models/AOP_38.ttl
+++ b/models/AOP_38.ttl
@@ -17,50 +17,51 @@
 
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0004021> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/CHEBI_3815> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0032964> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#collagen> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
-	<http://geneontology.org/lego/hint/layout/x> "607.7499847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "200.50001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "681.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "201.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_3815> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> <http://geneontology.org/lego/hint/layout/x> "338.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "204.25001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002296> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0032964> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cell%20death> <http://geneontology.org/lego/hint/layout/x> "316.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "897.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
+	<http://purl.obolibrary.org/obo/RO_0002304> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008213> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#protein%20alkylation> <http://geneontology.org/lego/hint/layout/x> "316.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1049.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0003304> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008213> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0002526> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#acute%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "340.74998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "526.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#acute%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "325.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "537.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002526> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000632> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -76,41 +77,42 @@
 	<http://geneontology.org/lego/hint/layout/y> "716"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#acute%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002263> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell> <http://geneontology.org/lego/hint/layout/x> "714.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "362.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000632> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> <http://geneontology.org/lego/hint/layout/x> "336.99998474121094"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "366.50001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
+	<http://purl.obolibrary.org/obo/RO_0004009> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0035733> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#liver> <http://geneontology.org/lego/hint/layout/x> "643.9999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "73.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
+<http://www.co-ode.org/ontologies/ont.owl#liver> <http://geneontology.org/lego/hint/layout/x> "798.9985046386719"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "73.2421760559082"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0002107> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> <http://geneontology.org/lego/hint/layout/x> "338.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> <http://purl.obolibrary.org/obo/RO_0004021> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
+	<http://geneontology.org/lego/hint/layout/x> "338.8833465576172"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "72"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0003333> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_38> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_38> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Protein Alkylation leading to Liver Fibrosis"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -118,11 +120,13 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002296> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002411> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0003304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0004009> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -130,58 +134,58 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3270 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
+_:t4668 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#liver> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3271 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4669 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#acute%20inflammatory%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3272 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4670 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3273 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4671 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation%20involved%20in%20immune%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#acute%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3274 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002296> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
+_:t4672 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3275 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
+_:t4673 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3276 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hepatic%20stellate%20cell%20activation> ;
+_:t4674 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004021> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#liver%20fibrosis> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#collagen%20biosynthetic%20process> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3277 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003304> ;
+_:t4675 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20alkylation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_40.ttl b/models/AOP_40.ttl
index 8ed6e079..b2308894 100644
--- a/models/AOP_40.ttl
+++ b/models/AOP_40.ttl
@@ -15,11 +15,11 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> <http://geneontology.org/lego/hint/layout/x> "254.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "363"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> <http://geneontology.org/lego/hint/layout/x> "250.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "192"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008283> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0001775> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -35,76 +35,77 @@
 
 <http://purl.obolibrary.org/obo/GO_0042110> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cell%20activation> <http://geneontology.org/lego/hint/layout/x> "558.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "622.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cell%20activation> <http://geneontology.org/lego/hint/layout/x> "571.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "595.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> , <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0001775> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#electrophilic%20reagant> <http://geneontology.org/lego/hint/layout/x> "708.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "903.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
+<http://www.co-ode.org/ontologies/ont.owl#electrophilic%20reagant> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
+	<http://geneontology.org/lego/hint/layout/x> "719.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1123.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_59739> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#memory%20T%20cell> <http://geneontology.org/lego/hint/layout/y> "446.25001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#memory%20T%20cell> <http://geneontology.org/lego/hint/layout/x> "55"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "28.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000813> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> <http://geneontology.org/lego/hint/layout/x> "263.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "610.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> <http://geneontology.org/lego/hint/layout/x> "253.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "586.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> , <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002396> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#protein%20binding> <http://geneontology.org/lego/hint/layout/x> "363.38330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "891.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#protein%20binding> <http://geneontology.org/lego/hint/layout/x> "361.38330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1123.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> , <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> , <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> , <http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005515> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#T%20cell> <http://geneontology.org/lego/hint/layout/x> "824.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "437.25001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#T%20cell> <http://geneontology.org/lego/hint/layout/x> "895.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "62.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000084> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> <http://geneontology.org/lego/hint/layout/x> "586.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "361"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> <http://geneontology.org/lego/hint/layout/x> "630.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "204"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0042110> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0002534> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0032980> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "1"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "782.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> <http://geneontology.org/lego/hint/layout/x> "2"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "888.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> , <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0002534> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> <http://geneontology.org/lego/hint/layout/x> "815.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "786.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> <http://geneontology.org/lego/hint/layout/x> "728.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "904.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> , <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0032980> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_40> <http://geneontology.org/lego/modelstate> "development"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_40> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Covalent Protein binding leading to Skin Sensitisation"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -112,8 +113,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0000056> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
@@ -122,105 +121,105 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3743 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4220 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3744 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4221 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3745 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4222 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#memory%20T%20cell> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3746 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4223 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3747 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4224 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3748 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4225 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3749 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4226 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3750 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4227 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3751 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4228 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#T%20cell> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-28"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3752 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4229 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#T%20cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3753 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4230 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20proliferation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3754 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4231 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3755 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4232 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cytokine%20production%20involved%20in%20inflammatory%20response> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20activation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3756 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+_:t4233 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#electrophilic%20reagant> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#protein%20binding> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-31"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3757 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4234 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#keratinocyte%20activation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#MHC%20protein%20complex%20assembly> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
diff --git a/models/AOP_42.ttl b/models/AOP_42.ttl
index 499e748e..434a333e 100644
--- a/models/AOP_42.ttl
+++ b/models/AOP_42.ttl
@@ -25,12 +25,12 @@
 
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> <http://geneontology.org/lego/hint/layout/x> "386.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "895.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> <http://geneontology.org/lego/hint/layout/x> "465.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "893.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002211> <http://www.co-ode.org/ontologies/ont.owl#hippocampal%20formation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010468> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CHEBI_30660> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -44,29 +44,29 @@
 	<http://geneontology.org/lego/hint/layout/x> "468"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1201.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005475> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
-	<http://geneontology.org/lego/hint/layout/x> "159.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://geneontology.org/lego/hint/layout/x> "159.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1349.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_60311> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
-	<http://geneontology.org/lego/hint/layout/x> "468.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1339.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> ;
+	<http://purl.obolibrary.org/obo/RO_0019000> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://geneontology.org/lego/hint/layout/x> "462.86669921875"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1343.4833374023438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006590> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "866.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1206.250015258789"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004447> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -76,15 +76,15 @@
 	<http://geneontology.org/lego/hint/layout/y> "1497.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004447> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#thyroid%20peroxidase> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#iodide%20peroxidase%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "1017.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1481"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "783.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1509"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000016584> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007268> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -98,32 +98,33 @@
 
 <http://purl.obolibrary.org/obo/UBERON_0002421> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain%20development> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
-	<http://geneontology.org/lego/hint/layout/x> "244.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "662.4999847412109"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#brain%20development> <http://geneontology.org/lego/hint/layout/x> "455.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "639.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007420> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cognition> , <http://www.co-ode.org/ontologies/ont.owl#learning%20or%20memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "249.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "515.2500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "234.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "500.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007268> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#cognition> <http://geneontology.org/lego/hint/layout/x> "476.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "360"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0050890> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#hippocampal%20formation> <http://geneontology.org/lego/hint/layout/x> "234"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "774.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#hippocampal%20formation> <http://geneontology.org/lego/hint/layout/x> "465"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "765.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002012> <http://www.co-ode.org/ontologies/ont.owl#brain%20development> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0002421> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#learning%20or%20memory> <http://geneontology.org/lego/hint/layout/x> "85"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "360"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -133,25 +134,24 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#synapse> <http://geneontology.org/lego/hint/layout/x> "612"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "524.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0001015> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0045202> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0010817> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> ;
-	<http://geneontology.org/lego/hint/layout/x> "467.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> <http://geneontology.org/lego/hint/layout/x> "467.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1055"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002411> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010817> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_42> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_42> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -161,84 +161,100 @@
 
 <http://purl.obolibrary.org/obo/RO_0002211> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0001015> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002462> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002012> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <https://noctua.apps.renci.org/model/AOP_42/64ecbbe400000020> <http://geneontology.org/lego/hint/layout/x> "85"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1056"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002462> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
+<http://purl.obolibrary.org/obo/RO_0002411> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3317 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
+_:t4639 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3318 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
+_:t4640 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4641 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_42/64ecbbe400000020> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3319 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4642 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20development> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4643 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3320 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4644 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cognition> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3321 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t4645 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning%20or%20memory> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3322 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002012> ;
+_:t4646 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002012> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#hippocampal%20formation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20development> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3323 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4647 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20peroxidase%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3324 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002211> ;
+_:t4648 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002211> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#hippocampal%20formation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3325 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002462> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_42/64ecbbe400000020> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+_:t4649 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002411> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-22"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_43.ttl b/models/AOP_43.ttl
index 5218f0d1..b8f7fa3a 100644
--- a/models/AOP_43.ttl
+++ b/models/AOP_43.ttl
@@ -15,20 +15,21 @@
 
 <http://purl.obolibrary.org/obo/GO_0001525> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#angiogenesis> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
-	<http://geneontology.org/lego/hint/layout/x> "325.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#angiogenesis> <http://geneontology.org/lego/hint/layout/x> "325.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "550.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0001525> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0003158> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> <http://geneontology.org/lego/hint/layout/x> "330.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "409"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000024> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003158> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008015> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -45,31 +46,31 @@
 <http://purl.obolibrary.org/obo/UBERON_0035753> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%201> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%202%20binding> ;
-	<http://geneontology.org/lego/hint/layout/x> "697.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "692.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "632.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "754.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000007563> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%202> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%202%20binding> ;
-	<http://geneontology.org/lego/hint/layout/x> "23"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "688.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "41"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "757.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000002112> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%202%20binding> <http://geneontology.org/lego/hint/layout/x> "332.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "685.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#angiogenesis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0043184> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_43> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_43> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Disruption of VEGFR Signaling Leading to Developmental Defects"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -77,15 +78,83 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/BFO_0000066> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0017003> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000024> <http://geneontology.org/lego/hint/layout/x> "329"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "274"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000027> ;
+	<http://purl.obolibrary.org/obo/RO_0004009> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000025> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008015> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000025> <http://geneontology.org/lego/hint/layout/x> "19"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "353"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0000178> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000026> <http://geneontology.org/lego/hint/layout/x> "572"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "98"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/UBERON_0035753> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000027> <http://geneontology.org/lego/hint/layout/x> "330"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "101"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/BFO_0000066> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000026> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0009653> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0004009> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3429 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4694 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#angiogenesis> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4695 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#endothelium%20development> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000024> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4696 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#vascular%20endothelial%20growth%20factor%20receptor%202%20binding> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#angiogenesis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-20"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4697 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004009> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000024> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000025> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4698 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000024> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000027> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-03"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4699 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/BFO_0000066> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000027> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_43/64ecbbe400000026> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_48.ttl b/models/AOP_48.ttl
index 38be224b..351f1925 100644
--- a/models/AOP_48.ttl
+++ b/models/AOP_48.ttl
@@ -39,26 +39,26 @@
 
 <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> <http://geneontology.org/lego/hint/layout/x> "133.88333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1794.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0000056> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
+	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_39124> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://geneontology.org/lego/hint/layout/x> "460.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
+	<http://geneontology.org/lego/hint/layout/x> "460.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1804.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0004025> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006816> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0005739> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
+<http://www.co-ode.org/ontologies/ont.owl#mitochondrion> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://geneontology.org/lego/hint/layout/x> "468.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1606.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0005739> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0008219> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -66,8 +66,8 @@
 	<http://geneontology.org/lego/hint/layout/x> "471.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1389"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008219> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/CL_0000127> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -77,33 +77,33 @@
 
 <http://purl.obolibrary.org/obo/MP_0002229> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#astrocyte> <http://geneontology.org/lego/hint/layout/x> "837.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1006"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0001015> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+<http://www.co-ode.org/ontologies/ont.owl#astrocyte> <http://purl.obolibrary.org/obo/RO_0002331> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+	<http://geneontology.org/lego/hint/layout/x> "849.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1003"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000127> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	<http://geneontology.org/lego/hint/layout/x> "270.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> <http://geneontology.org/lego/hint/layout/x> "270.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "923.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002304> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://geneontology.org/lego/hint/layout/x> "52"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> <http://purl.obolibrary.org/obo/RO_0002331> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://geneontology.org/lego/hint/layout/x> "52"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1022"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0001015> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CL_0000129> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> <http://purl.obolibrary.org/obo/RO_0004024> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
-	<http://geneontology.org/lego/hint/layout/x> "430.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "746.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "420.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "736.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004972> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -113,15 +113,15 @@
 	<http://geneontology.org/lego/hint/layout/y> "2012.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004972> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	<http://geneontology.org/lego/hint/layout/x> "864.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1999"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0017146> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007612> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -130,33 +130,33 @@
 <http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "589.63330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "283"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "257.8833312988281"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "300"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007613> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "417.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "433.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://geneontology.org/lego/hint/layout/x> "429.7461700439453"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "508.23860931396484"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0004970> a <http://www.w3.org/2002/07/owl#Class> .
 
 <http://purl.obolibrary.org/obo/GO_0008328> a <http://www.w3.org/2002/07/owl#Class> .
 
-<https://noctua.apps.renci.org/model/AOP_48> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_48> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment."^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -164,112 +164,161 @@
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0000056> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
-<http://purl.obolibrary.org/obo/RO_0001015> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
-<http://purl.obolibrary.org/obo/RO_0004025> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
-<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> , <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> , <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
 	<http://geneontology.org/lego/hint/layout/x> "468"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1134"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002229> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
-	<http://geneontology.org/lego/hint/layout/x> "617"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> <http://geneontology.org/lego/hint/layout/x> "617"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "920"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002304> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001847> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
+<http://purl.obolibrary.org/obo/RO_0002352> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000022> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000023> ;
+	<http://geneontology.org/lego/hint/layout/x> "907.9015045166016"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2266.8900146484375"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008328> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000023> <http://geneontology.org/lego/hint/layout/x> "488.95448303222656"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2267.9468383789062"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0004970> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0017003> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
+<http://purl.obolibrary.org/obo/RO_0002304> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/contributor> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2737 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
+_:t5131 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#astrocyte> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5132 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002331> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5133 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2738 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t5134 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5135 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2739 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t5136 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-18"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2740 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t5137 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002304> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000008> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5138 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000022> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000023> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-02"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2741 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+_:t5139 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000023> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-02"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5140 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2742 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t5141 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2743 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t5142 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2744 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t5143 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2745 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000056> ;
+_:t5144 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002304> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-16"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t5145 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2746 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004025> ;
+_:t5146 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002410> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#mitochondrion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2747 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+_:t5147 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#cell%20death> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_48/64ecbbe400000007> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
-
-_:t2748 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0001015> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> ;
-	a <http://www.w3.org/2002/07/owl#Axiom> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-12"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_54.ttl b/models/AOP_54.ttl
index bfc314b3..c2774dfe 100644
--- a/models/AOP_54.ttl
+++ b/models/AOP_54.ttl
@@ -15,8 +15,6 @@
 
 <http://purl.obolibrary.org/obo/RO_0000053> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
-<http://purl.obolibrary.org/obo/RO_0002566> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
-
 <http://purl.obolibrary.org/obo/RO_0002610> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0004021> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -43,37 +41,37 @@
 	<http://purl.obolibrary.org/obo/RO_0002503> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0005475> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#iodide> a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_16382> .
 
 <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> <http://purl.obolibrary.org/obo/RO_0002233> <http://www.co-ode.org/ontologies/ont.owl#iodide> ;
-	<http://geneontology.org/lego/hint/layout/x> "282.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "2605.9999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "274"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2605"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0015705> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
-	<http://geneontology.org/lego/hint/layout/x> "652.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> <http://geneontology.org/lego/hint/layout/x> "652.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2409.9999237060547"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_60311> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://geneontology.org/lego/hint/layout/x> "289.88331604003906"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> <http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> ;
+	<http://geneontology.org/lego/hint/layout/x> "289.88331604003906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2401.7499237060547"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006590> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "671.7500152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "2251.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#thyroxine> <http://geneontology.org/lego/hint/layout/x> "670.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2242.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0010467> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -82,7 +80,7 @@
 	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010467> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002233> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
@@ -98,26 +96,26 @@
 
 <http://purl.obolibrary.org/obo/PR_000015171> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+<http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> <http://purl.obolibrary.org/obo/RO_0002610> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> , <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	<http://geneontology.org/lego/hint/layout/x> "282.75001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2036.2499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0010817> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#sodium/iodide%20cotransporter> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	<http://geneontology.org/lego/hint/layout/x> "621.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "2758.5000610351562"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "613.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "2760.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000015171> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> <http://geneontology.org/lego/hint/layout/x> "276"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "2762.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0008507> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0046903> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -125,11 +123,11 @@
 
 <http://purl.obolibrary.org/obo/GO_0007613> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "532.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "1128"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#learning> <http://geneontology.org/lego/hint/layout/x> "548.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "1129"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007612> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#memory> <http://geneontology.org/lego/hint/layout/x> "96"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1129"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -139,28 +137,28 @@
 
 <http://purl.obolibrary.org/obo/GO_0099536> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://purl.obolibrary.org/obo/RO_0002566> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
-	<http://geneontology.org/lego/hint/layout/x> "327.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> <http://geneontology.org/lego/hint/layout/x> "327.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1301.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.obolibrary.org/obo/RO_0017003> <http://www.co-ode.org/ontologies/ont.owl#learning> , <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0099536> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000004716> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://geneontology.org/lego/hint/layout/x> "17.000015258789062"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
+	<http://geneontology.org/lego/hint/layout/x> "17.000015258789062"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1947.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#secretion> <http://geneontology.org/lego/hint/layout/x> "151.00001525878906"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1836"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0046903> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0007416> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -170,7 +168,7 @@
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0007416> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/MP_0002882> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -179,13 +177,13 @@
 	<http://geneontology.org/lego/hint/layout/y> "1653.7499389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002882> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_54> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment "^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> , "https://orcid.org/0000-0002-5167-9928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -204,14 +202,16 @@
 	<http://purl.obolibrary.org/obo/RO_0002352> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_30660> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000019> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://geneontology.org/lego/hint/layout/x> "829.0000152587891"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "1819.9999389648438"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000004716> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-27"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-08"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0017003> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -219,107 +219,128 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t3525 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+_:t4581 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3526 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+_:t4582 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4583 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4584 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synapse> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3527 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+_:t4585 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#learning> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3528 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002566> ;
+_:t4586 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0017003> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#memory> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4587 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3529 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+_:t4588 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3530 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4589 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000018> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3531 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+_:t4590 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_54/64ecbbe400000019> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3532 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
+_:t4591 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002503> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroxine> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3533 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
+_:t4592 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0004024> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20circulating%20thyroxine%20level> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3534 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002352> ;
+_:t4593 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3535 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+_:t4594 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20neuron%20morphology> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3536 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4595 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#thyroid%20hormone%20generation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3537 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
+_:t4596 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002233> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#iodide> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-26"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3538 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#sodium%3Aiodide%20symporter%20activity> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#iodide%20transport> ;
+_:t4597 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#secretion> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t3539 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#synapse%20assembly> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#synaptic%20signaling> ;
+_:t4598 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002610> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#regulation%20of%20hormone%20levels> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#gene%20expression> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-21"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-11-07"^^<http://www.w3.org/2001/XMLSchema#string> .
diff --git a/models/AOP_6.ttl b/models/AOP_6.ttl
index 6835ceda..fd725ffb 100644
--- a/models/AOP_6.ttl
+++ b/models/AOP_6.ttl
@@ -13,6 +13,8 @@
 
 <http://purl.obolibrary.org/obo/RO_0002428> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
+<http://purl.obolibrary.org/obo/RO_0003303> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
+
 <http://purl.obolibrary.org/obo/RO_0019000> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0000057> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
@@ -21,12 +23,12 @@
 
 <http://purl.obolibrary.org/obo/GO_0006635> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> <http://geneontology.org/lego/hint/layout/x> "137.63333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "449.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> <http://geneontology.org/lego/hint/layout/x> "86.63333129882812"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "405.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0006635> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/PR_000013056> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -35,7 +37,7 @@
 	<http://geneontology.org/lego/hint/layout/y> "915.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000013056> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/GO_0035624> a <http://www.w3.org/2002/07/owl#Class> .
 
@@ -59,57 +61,56 @@
 
 <http://purl.obolibrary.org/obo/PR_000011048> a <http://www.w3.org/2002/07/owl#Class> .
 
-<http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> <http://geneontology.org/lego/hint/layout/x> "548.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "177"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+<http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> <http://geneontology.org/lego/hint/layout/x> "528.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "199"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0002118> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> <http://purl.obolibrary.org/obo/RO_0002353> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
-	<http://geneontology.org/lego/hint/layout/x> "862.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "397"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "929.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "373"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/CHEBI_73693> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#ketosis> <http://purl.obolibrary.org/obo/RO_0002410> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
+<http://www.co-ode.org/ontologies/ont.owl#ketosis> <http://purl.obolibrary.org/obo/RO_0003303> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
 	<http://purl.obolibrary.org/obo/RO_0002234> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
-	<http://geneontology.org/lego/hint/layout/x> "540.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "390.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "530.75"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "388.25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://id.nlm.nih.gov/mesh/D007662> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> <http://geneontology.org/lego/hint/layout/x> "531.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "558.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> <http://geneontology.org/lego/hint/layout/x> "535.88330078125"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "564.5"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> , <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0035624> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<http://www.co-ode.org/ontologies/ont.owl#weight%20loss> <http://geneontology.org/lego/hint/layout/x> "63"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<http://www.co-ode.org/ontologies/ont.owl#weight%20loss> <http://geneontology.org/lego/hint/layout/x> "124"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "32"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/MP_0001263> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6> <http://geneontology.org/lego/modelstate> "review"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6> <http://geneontology.org/lego/modelstate> "production"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#Ontology> ;
 	<http://purl.org/dc/elements/1.1/title> "Antagonist binding to PPARα leading to body-weight loss"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://geneontology.org/lego/hint/layout/x> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
 <http://geneontology.org/lego/hint/layout/y> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> <http://geneontology.org/lego/hint/layout/x> "529"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "917"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> <http://geneontology.org/lego/hint/layout/x> "558"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "913"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002213> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0048019> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000002> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	<http://geneontology.org/lego/hint/layout/x> "160"^^<http://www.w3.org/2001/XMLSchema#string> ;
@@ -119,44 +120,48 @@
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000003> <http://purl.obolibrary.org/obo/RO_0002327> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
-	<http://geneontology.org/lego/hint/layout/x> "839"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "723"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "930"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "716"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000011047> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> <http://geneontology.org/lego/hint/layout/x> "530"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> <http://geneontology.org/lego/hint/layout/x> "524"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://geneontology.org/lego/hint/layout/y> "733"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0003714> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> <http://purl.obolibrary.org/obo/RO_0000057> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> ;
-	<http://geneontology.org/lego/hint/layout/x> "547"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "539"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "25"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.obolibrary.org/obo/RO_0002212> <http://www.co-ode.org/ontologies/ont.owl#weight%20loss> ;
+	<http://purl.obolibrary.org/obo/RO_0019001> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/GO_0030163> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://purl.obolibrary.org/obo/RO_0002213> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.obolibrary.org/obo/RO_0002212> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000011> <http://purl.obolibrary.org/obo/RO_0002327> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
-	<http://geneontology.org/lego/hint/layout/x> "844"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "553"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/x> "928"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "549"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://purl.obolibrary.org/obo/PR_000013056> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
 
 <http://n2t.net/MESH:D009124> a <http://www.w3.org/2002/07/owl#Class> .
 
-<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> <http://geneontology.org/lego/hint/layout/x> "828"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://geneontology.org/lego/hint/layout/y> "25"^^<http://www.w3.org/2001/XMLSchema#string> ;
+<https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> <http://geneontology.org/lego/hint/layout/x> "924"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://geneontology.org/lego/hint/layout/y> "37"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	a <http://www.w3.org/2002/07/owl#NamedIndividual> , <http://n2t.net/MESH:D009124> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+<http://purl.obolibrary.org/obo/RO_0019001> a <http://www.w3.org/2002/07/owl#ObjectProperty> .
 
 <http://purl.org/dc/elements/1.1/title> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
@@ -164,98 +169,105 @@
 
 <http://purl.org/dc/elements/1.1/date> a <http://www.w3.org/2002/07/owl#AnnotationProperty> .
 
-_:t2800 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
+_:t4144 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002234> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2801 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4145 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000003> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2802 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4146 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2803 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000057> ;
+_:t4147 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0000057> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000012> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2804 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
+_:t4148 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002212> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#weight%20loss> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2805 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4149 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0019001> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
+	a <http://www.w3.org/2002/07/owl#Axiom> ;
+	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
+	<http://purl.org/dc/elements/1.1/date> "2023-10-25"^^<http://www.w3.org/2001/XMLSchema#string> .
+
+_:t4150 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000011> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2806 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
-	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
-	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000005> ;
+_:t4151 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0003303> ;
+	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
+	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#abnormal%20lipid%20homeostasis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
-	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
+	<http://purl.org/dc/elements/1.1/date> "2023-10-12"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2807 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4152 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2808 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
+_:t4153 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002353> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#ketone%20body> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2809 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4154 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#peroxisome%20proliferator-activated%20receptor%20alpha> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-08"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2810 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4155 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#ketosis> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2811 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4156 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <http://www.co-ode.org/ontologies/ont.owl#receptor%20transactivation> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <http://www.co-ode.org/ontologies/ont.owl#fatty%20acid%20beta-oxidation> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-14"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2812 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
+_:t4157 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002213> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000001> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;
 	<http://purl.org/dc/elements/1.1/contributor> "https://orcid.org/0000-0001-9356-3475"^^<http://www.w3.org/2001/XMLSchema#string> ;
 	<http://purl.org/dc/elements/1.1/date> "2023-09-15"^^<http://www.w3.org/2001/XMLSchema#string> .
 
-_:t2813 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
+_:t4158 <http://www.w3.org/2002/07/owl#annotatedProperty> <http://purl.obolibrary.org/obo/RO_0002327> ;
 	<http://www.w3.org/2002/07/owl#annotatedSource> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000002> ;
 	<http://www.w3.org/2002/07/owl#annotatedTarget> <https://noctua.apps.renci.org/model/AOP_6/64ecbbe400000004> ;
 	a <http://www.w3.org/2002/07/owl#Axiom> ;