From b404cd2d8287d9d9418f915c5495801b908b5b03 Mon Sep 17 00:00:00 2001 From: Chris Mungall Date: Wed, 20 Dec 2023 14:56:59 -0800 Subject: [PATCH] Enhanced implementations for remote endpoints. (#682) * Enhanced implementations for remote endpoints. Added ability to query gene associations from NCBI Added ability to query amigo for terms and relationships * lint * add missing * add missing --- src/oaklib/cli.py | 17 +- src/oaklib/datamodels/association.py | 52 +- src/oaklib/datamodels/association.yaml | 16 + src/oaklib/implementations/__init__.py | 2 + .../amigo/amigo_implementation.py | 118 +- src/oaklib/implementations/ncbi/__init__.py | 0 .../ncbi/ncbi_gene_implementation.py | 184 + .../uniprot/uniprot_implementation.py | 115 +- .../interfaces/basic_ontology_interface.py | 3 + src/oaklib/interfaces/dumper_interface.py | 18 +- src/oaklib/utilities/keyval_cache.py | 39 + src/oaklib/utilities/table_filler.py | 16 +- tests/input/ncbigene-1956.xml | 635814 +++++++++++++++ tests/input/uniprot-P12345.json | 1898 + tests/test_implementations/test_ncbigene.py | 46 + tests/test_implementations/test_uniprot.py | 38 + 16 files changed, 638356 insertions(+), 20 deletions(-) create mode 100644 src/oaklib/implementations/ncbi/__init__.py create mode 100644 src/oaklib/implementations/ncbi/ncbi_gene_implementation.py create mode 100644 src/oaklib/utilities/keyval_cache.py create mode 100644 tests/input/ncbigene-1956.xml create mode 100644 tests/input/uniprot-P12345.json create mode 100644 tests/test_implementations/test_ncbigene.py create mode 100644 tests/test_implementations/test_uniprot.py diff --git a/src/oaklib/cli.py b/src/oaklib/cli.py index 70a200062..092fb44a8 100644 --- a/src/oaklib/cli.py +++ b/src/oaklib/cli.py @@ -1006,8 +1006,9 @@ def main( @main.command() @click.argument("terms", nargs=-1) @ontological_output_type_option +@autolabel_option @output_option -def search(terms, output_type: str, output: TextIO): +def search(terms, output_type: str, autolabel, output: TextIO): """ Searches ontology for entities that have a label, alias, or other property matching a search term. @@ -1056,11 +1057,15 @@ def search(terms, output_type: str, output: TextIO): if isinstance(impl, SearchInterface): writer = _get_writer(output_type, impl, StreamingInfoWriter) writer.output = output - for curie_it in chunk(query_terms_iterator(terms, impl)): - logging.info("** Next chunk:") - # TODO: move chunking logic to writer - for curie, label in impl.labels(curie_it): - writer.emit(dict(id=curie, label=label)) + if autolabel: + for curie_it in chunk(query_terms_iterator(terms, impl)): + logging.info("** Next chunk:") + # TODO: move chunking logic to writer + for curie, label in impl.labels(curie_it): + writer.emit(dict(id=curie, label=label)) + else: + for curie in query_terms_iterator(terms, impl): + writer.emit(dict(id=curie), label_fields=[]) writer.finish() else: raise NotImplementedError(f"Cannot execute this using {impl} of type {type(impl)}") diff --git a/src/oaklib/datamodels/association.py b/src/oaklib/datamodels/association.py index 7bde7c455..2da07bb06 100644 --- a/src/oaklib/datamodels/association.py +++ b/src/oaklib/datamodels/association.py @@ -1,5 +1,5 @@ -# Auto generated from association.yaml by pythongen.py version: 0.9.0 -# Generation date: 2023-08-14T15:53:04 +# Auto generated from association.yaml by pythongen.py version: 0.0.1 +# Generation date: 2023-11-17T17:56:03 # Schema: association # # id: https://w3id.org/oak/association @@ -69,6 +69,7 @@ OA = CurieNamespace("oa", "http://www.w3.org/ns/oa#") ONTOASSOC = CurieNamespace("ontoassoc", "https://w3id.org/oak/association/") RDF = CurieNamespace("rdf", "http://example.org/UNKNOWN/rdf/") +RDFS = CurieNamespace("rdfs", "http://example.org/UNKNOWN/rdfs/") SSSOM = CurieNamespace("sssom", "https://w3id.org/sssom/") DEFAULT_ = ONTOASSOC @@ -100,6 +101,10 @@ class PositiveOrNegativeAssociation(YAMLRoot): publications: Optional[ Union[Union[str, URIorCURIE], List[Union[str, URIorCURIE]]] ] = empty_list() + evidence_type: Optional[Union[str, URIorCURIE]] = None + supporting_objects: Optional[ + Union[Union[str, URIorCURIE], List[Union[str, URIorCURIE]]] + ] = empty_list() primary_knowledge_source: Optional[Union[str, URIorCURIE]] = None aggregator_knowledge_source: Optional[Union[str, URIorCURIE]] = None subject_closure: Optional[ @@ -110,6 +115,7 @@ class PositiveOrNegativeAssociation(YAMLRoot): Union[Union[str, URIorCURIE], List[Union[str, URIorCURIE]]] ] = empty_list() object_closure_label: Optional[Union[str, List[str]]] = empty_list() + comments: Optional[Union[str, List[str]]] = empty_list() def __post_init__(self, *_: List[str], **kwargs: Dict[str, Any]): if self.subject is not None and not isinstance(self.subject, URIorCURIE): @@ -148,6 +154,17 @@ def __post_init__(self, *_: List[str], **kwargs: Dict[str, Any]): v if isinstance(v, URIorCURIE) else URIorCURIE(v) for v in self.publications ] + if self.evidence_type is not None and not isinstance(self.evidence_type, URIorCURIE): + self.evidence_type = URIorCURIE(self.evidence_type) + + if not isinstance(self.supporting_objects, list): + self.supporting_objects = ( + [self.supporting_objects] if self.supporting_objects is not None else [] + ) + self.supporting_objects = [ + v if isinstance(v, URIorCURIE) else URIorCURIE(v) for v in self.supporting_objects + ] + if self.primary_knowledge_source is not None and not isinstance( self.primary_knowledge_source, URIorCURIE ): @@ -188,6 +205,10 @@ def __post_init__(self, *_: List[str], **kwargs: Dict[str, Any]): v if isinstance(v, str) else str(v) for v in self.object_closure_label ] + if not isinstance(self.comments, list): + self.comments = [self.comments] if self.comments is not None else [] + self.comments = [v if isinstance(v, str) else str(v) for v in self.comments] + super().__post_init__(**kwargs) @@ -711,6 +732,33 @@ class slots: range=Optional[Union[str, URIorCURIE]], ) +slots.evidence_type = Slot( + uri=ONTOASSOC.evidence_type, + name="evidence_type", + curie=ONTOASSOC.curie("evidence_type"), + model_uri=ONTOASSOC.evidence_type, + domain=None, + range=Optional[Union[str, URIorCURIE]], +) + +slots.supporting_objects = Slot( + uri=ONTOASSOC.supporting_objects, + name="supporting_objects", + curie=ONTOASSOC.curie("supporting_objects"), + model_uri=ONTOASSOC.supporting_objects, + domain=None, + range=Optional[Union[Union[str, URIorCURIE], List[Union[str, URIorCURIE]]]], +) + +slots.comments = Slot( + uri=RDFS.comment, + name="comments", + curie=RDFS.curie("comment"), + model_uri=ONTOASSOC.comments, + domain=None, + range=Optional[Union[str, List[str]]], +) + slots.denormalized_slot = Slot( uri=ONTOASSOC.denormalized_slot, name="denormalized_slot", diff --git a/src/oaklib/datamodels/association.yaml b/src/oaklib/datamodels/association.yaml index 9948af003..8028299cc 100644 --- a/src/oaklib/datamodels/association.yaml +++ b/src/oaklib/datamodels/association.yaml @@ -41,12 +41,15 @@ classes: - object_label - negated - publications + - evidence_type + - supporting_objects - primary_knowledge_source - aggregator_knowledge_source - subject_closure - subject_closure_label - object_closure - object_closure_label + - comments Association: is_a: PositiveOrNegativeAssociation @@ -242,6 +245,18 @@ slots: description: The knowledge source that aggregated the association slot_uri: biolink:aggregator_knowledge_source range: uriorcurie + evidence_type: + description: The type of evidence supporting the association + range: uriorcurie + supporting_objects: + description: The objects that support the association + range: uriorcurie + multivalued: true + comments: + description: Comments about the association + slot_uri: rdfs:comment + range: string + multivalued: true denormalized_slot: mixin: true description: |- @@ -387,3 +402,4 @@ slots: associations_for_subjects_in_common: multivalued: true range: Association + diff --git a/src/oaklib/implementations/__init__.py b/src/oaklib/implementations/__init__.py index dcabc5ce7..8ef19c563 100644 --- a/src/oaklib/implementations/__init__.py +++ b/src/oaklib/implementations/__init__.py @@ -17,6 +17,7 @@ from oaklib.implementations.kgx.kgx_implementation import KGXImplementation from oaklib.implementations.llm_implementation import LLMImplementation from oaklib.implementations.monarch.monarch_implementation import MonarchImplementation +from oaklib.implementations.ncbi.ncbi_gene_implementation import NCBIGeneImplementation from oaklib.implementations.ols import ( BaseOlsImplementation, OlsImplementation, @@ -77,6 +78,7 @@ "OlsImplementation", "TIBOlsImplementation", "MonarchImplementation", + "NCBIGeneImplementation", "OntobeeImplementation", "ProntoImplementation", "SimpleOboImplementation", diff --git a/src/oaklib/implementations/amigo/amigo_implementation.py b/src/oaklib/implementations/amigo/amigo_implementation.py index dc9a68b5a..3cc46783c 100644 --- a/src/oaklib/implementations/amigo/amigo_implementation.py +++ b/src/oaklib/implementations/amigo/amigo_implementation.py @@ -1,12 +1,16 @@ """Adapter for AmiGO solr index.""" +import json import logging from dataclasses import dataclass from time import sleep -from typing import Any, Dict, Iterable, Iterator, List, Optional +from typing import Any, Dict, Iterable, Iterator, List, Optional, Tuple import pysolr from oaklib.datamodels.association import Association +from oaklib.datamodels.search import SearchConfiguration +from oaklib.datamodels.vocabulary import RDFS_LABEL +from oaklib.interfaces import SearchInterface from oaklib.interfaces.association_provider_interface import ( AssociationProviderInterface, ) @@ -15,8 +19,9 @@ "AmiGOImplementation", ] -from oaklib.interfaces.basic_ontology_interface import LANGUAGE_TAG +from oaklib.interfaces.basic_ontology_interface import LANGUAGE_TAG, RELATIONSHIP from oaklib.types import CURIE, PRED_CURIE +from oaklib.utilities.iterator_utils import chunk AMIGO_ENDPOINT = "http://golr.geneontology.org/solr/" @@ -24,6 +29,8 @@ LIMIT = 10000 +ONTOLOGY_CLASS_CATEGORY = "ontology_class" + # TODO: derive from schema DOCUMENT_CATEGORY = "document_category" BIOENTITY = "bioentity" @@ -36,6 +43,10 @@ ASSIGNED_BY = "assigned_by" REFERENCE = "reference" +NEIGHBORHOOD_GRAPH_JSON = "neighborhood_graph_json" +TOPOLOGY_GRAPH_JSON = "topology_graph_json" +REGULATES_TRANSITIVITY_GRAPH_JSON = "regulates_transitivity_graph_json" + # general ENTITY = "entity" ENTITY_LABEL = "entity_label" @@ -57,15 +68,20 @@ def _fq_element(k, vs): return f"{k}:({v})" -def _query(solr, fq, fields, start: int = None, limit: int = None) -> Iterator[Dict]: +def _query( + solr, fq, fields, q=None, start: int = None, limit: int = None, **kwargs +) -> Iterator[Dict]: if start is None: start = 0 if limit is None: limit = LIMIT fq_list = [_fq_element(k, vs) for k, vs in fq.items()] - params = {"fq": fq_list, "fl": ",".join(fields)} + params = {"fq": fq_list, "fl": ",".join(fields), **kwargs} + if not q: + q = "*:*" + logging.info(f"QUERY: {q} PARAMS: {params}") while True: - results = solr.search("*:*", rows=limit, start=start, **params) + results = solr.search(q, rows=limit, start=start, **params) yield from results logging.debug(f"CHECKING: {start} + {len(results)} >= {results.hits}") if start + len(results) >= results.hits: @@ -90,6 +106,7 @@ def _normalize(curie: CURIE) -> CURIE: @dataclass class AmiGOImplementation( AssociationProviderInterface, + SearchInterface, ): """ Wraps AmiGO endpoint. @@ -121,14 +138,48 @@ def __post_init__(self): self._source = self.resource.slug self._solr = pysolr.Solr(AMIGO_ENDPOINT) + def _cache_nodes(self, nodes: List[Dict], curies: Iterable[CURIE]): + for node in nodes: + curie = node["id"] + if curie in curies: + lbl = node.get("lbl", None) + if lbl: + self.property_cache.add(curie, RDFS_LABEL, node["lbl"]) + def label(self, curie: CURIE, lang: Optional[LANGUAGE_TAG] = None) -> Optional[str]: if lang: raise NotImplementedError + if self.property_cache.contains(curie, RDFS_LABEL): + return self.property_cache.get(curie, RDFS_LABEL) fq = {"document_category": ["general"], ENTITY: [curie]} solr = self._solr results = _query(solr, fq, [ENTITY_LABEL]) + self.property_cache.add(curie, RDFS_LABEL, None) for doc in results: - return doc[ENTITY_LABEL] + lbl = doc[ENTITY_LABEL] + self.property_cache.add(curie, RDFS_LABEL, lbl) + return lbl + + def labels( + self, curies: Iterable[CURIE], allow_none=True, lang: LANGUAGE_TAG = None + ) -> Iterable[Tuple[CURIE, str]]: + if lang: + raise NotImplementedError + # Note: some issues with post, use a low chunk size to ensure GET + for curie_it in chunk(curies, 10): + next_curies = list(curie_it) + for curie in next_curies: + lbl = self.property_cache.get(curie, RDFS_LABEL) + if lbl is not None: + yield curie, lbl + next_curies.remove(curie) + if not next_curies: + continue + fq = {"document_category": ["general"], ENTITY: next_curies} + solr = self._solr + results = _query(solr, fq, [ENTITY, ENTITY_LABEL]) + for doc in results: + yield doc[ENTITY], doc[ENTITY_LABEL] def associations( self, @@ -179,3 +230,58 @@ def associations( assoc.subject_closure = doc[ISA_PARTOF_CLOSURE] assoc.subject_closure_label = doc[ISA_PARTOF_CLOSURE_LABEL] yield assoc + + def relationships( + self, + subjects: Iterable[CURIE] = None, + predicates: Iterable[PRED_CURIE] = None, + objects: Iterable[CURIE] = None, + include_tbox: bool = True, + include_abox: bool = True, + include_entailed: bool = False, + exclude_blank: bool = True, + ) -> Iterator[RELATIONSHIP]: + solr = self._solr + fq = {DOCUMENT_CATEGORY: [ONTOLOGY_CLASS_CATEGORY]} + # neighborhood graph is indexed for both subject and object + if subjects: + subjects = list(subjects) + fq[ANNOTATION_CLASS] = subjects + elif objects: + objects = list(objects) + fq[ANNOTATION_CLASS] = objects + select_fields = [ANNOTATION_CLASS, NEIGHBORHOOD_GRAPH_JSON] + if include_entailed: + select_fields.append(REGULATES_TRANSITIVITY_GRAPH_JSON) + results = _query(solr, fq, select_fields) + + for doc in results: + neighborhood_graph = json.loads(doc[NEIGHBORHOOD_GRAPH_JSON]) + edges = neighborhood_graph["edges"] + nodes = neighborhood_graph["nodes"] + if include_entailed: + closure_graph = json.loads(doc[REGULATES_TRANSITIVITY_GRAPH_JSON]) + edges.extend(closure_graph["edges"]) + if subjects: + edges = [e for e in edges if e["sub"] in subjects] + if objects: + edges = [e for e in edges if e["obj"] in objects] + if predicates: + edges = [e for e in edges if e["pred"] in predicates] + for edge in edges: + s, p, o = edge["sub"], edge["pred"], edge["obj"] + self._cache_nodes(nodes, [s, p, o]) + yield s, p, o + + def basic_search( + self, search_term: str, config: Optional[SearchConfiguration] = None + ) -> Iterable[CURIE]: + solr = self._solr + fq = {DOCUMENT_CATEGORY: ["general"]} + # fq["general_blob"] = search_term + results = _query( + solr, fq, ["entity"], q=search_term, qf="general_blob_searchable", defType="edismax" + ) + + for doc in results: + yield doc["entity"] diff --git a/src/oaklib/implementations/ncbi/__init__.py b/src/oaklib/implementations/ncbi/__init__.py new file mode 100644 index 000000000..e69de29bb diff --git a/src/oaklib/implementations/ncbi/ncbi_gene_implementation.py b/src/oaklib/implementations/ncbi/ncbi_gene_implementation.py new file mode 100644 index 000000000..e652dc104 --- /dev/null +++ b/src/oaklib/implementations/ncbi/ncbi_gene_implementation.py @@ -0,0 +1,184 @@ +"""Adapter for NCBIGene solr index.""" +import logging +from dataclasses import dataclass +from typing import Any, Dict, Iterable, Iterator, List, Optional, Tuple +from xml.etree import ElementTree # noqa S405 + +import requests + +from oaklib.datamodels.association import Association +from oaklib.datamodels.search import SearchConfiguration +from oaklib.datamodels.vocabulary import RDFS_LABEL +from oaklib.interfaces import SearchInterface +from oaklib.interfaces.association_provider_interface import ( + AssociationProviderInterface, +) + +__all__ = [ + "NCBIGeneImplementation", +] + +from oaklib.interfaces.basic_ontology_interface import LANGUAGE_TAG +from oaklib.types import CURIE, PRED_CURIE + +EFETCH_URL = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi" +ESEARCH_URL = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi" + +logger = logging.getLogger(__name__) + + +@dataclass +class NCBIGeneImplementation( + AssociationProviderInterface, + SearchInterface, +): + """ + Wraps NCBIGene endpoint. + + The general form of the argument to :ref:`get_adapter()` is ``NCBIGene:``: + + >>> from oaklib import get_adapter + >>> NCBIGene = get_adapter("NCBIGene:NCBITaxon:9606") + >>> gene_products = sorted([a.subject for a in NCBIGene.associations(objects=["GO:0098794"])]) + >>> for gp in gene_products: + ... print(gp) + + ... + UniProtKB:P14867 + ... + UniProtKB:P23677 + ... + + On the command line: + + + + """ + + def __post_init__(self): + self._source = self.resource.slug + # self._solr = pysolr.Solr(NCBIGene_ENDPOINT) + + def label(self, curie: CURIE, lang: Optional[LANGUAGE_TAG] = None) -> Optional[str]: + if lang: + raise NotImplementedError + for _, lbl in self.labels([curie]): + return lbl + + def labels( + self, curies: Iterable[CURIE], allow_none=True, lang: LANGUAGE_TAG = None + ) -> Iterable[Tuple[CURIE, str]]: + if lang: + raise NotImplementedError + for curie in curies: + yield curie, self.property_cache.get(curie, RDFS_LABEL) + + def associations( + self, + subjects: Iterable[CURIE] = None, + predicates: Iterable[PRED_CURIE] = None, + objects: Iterable[CURIE] = None, + property_filter: Dict[PRED_CURIE, Any] = None, + subject_closure_predicates: Optional[List[PRED_CURIE]] = None, + predicate_closure_predicates: Optional[List[PRED_CURIE]] = None, + object_closure_predicates: Optional[List[PRED_CURIE]] = None, + include_modified: bool = False, + add_closure_fields: bool = False, + **kwargs, + ) -> Iterator[Association]: + logging.info(f"SUBJS: {subjects}") + if subjects: + subjects = list(subjects) + if not subjects: + raise ValueError("NCBIGene requires subjects") + + for subject in subjects: + if subject.startswith("NCBIGene:"): + gene_id = subject.split(":")[1] + elif subject.isnumeric(): + gene_id = subject + else: + raise ValueError("NCBIGene requires subjects to be NCBIGene CURIEs or numbers") + params = { + "db": "gene", + "id": gene_id, + "retmode": "xml", + } + response = requests.get(EFETCH_URL, params) + + # Parsing the XML file + root = ElementTree.fromstring(response.content) # noqa S314 + + yield from self.associations_from_xml(subject, root) + + def associations_from_xml(self, subject, root): + """ + Extracts associations from the XML file + + :param subject: + :param root: + :return: + """ + gene_symbol = None + for gene_ref in root.iter("Gene-ref_locus"): + gene_symbol = gene_ref.text + self.property_cache.add(subject, RDFS_LABEL, gene_ref.text) + + # Searching for GO annotations in the specified structure + subpath = "Gene-commentary/Gene-commentary_comment" + for gene_commentary in root.findall( + f".//Entrezgene_properties/{subpath}/{subpath}/Gene-commentary" + ): + pmids = set() + for pmid in gene_commentary.iter("PubMedId"): + pmids.add(f"PMID:{pmid.text}") + for gene_commentary_source in gene_commentary.iter("Gene-commentary_source"): + for other_source in gene_commentary_source: + # Check if the source is a GO term + if other_source.find("Other-source_src/Dbtag/Dbtag_db") is not None: + db_tag = other_source.find("Other-source_src/Dbtag/Dbtag_db").text + if db_tag == "GO": # Confirming it's a GO term + # Extracting the GO ID + go_id = other_source.find( + "Other-source_src/Dbtag/Dbtag_tag/Object-id/Object-id_id" + ).text + go_id = f"GO:{int(go_id):07d}" + go_label = other_source.find("Other-source_anchor").text + self.property_cache.add(go_id, RDFS_LABEL, go_label) + predicate = other_source.find("Other-source_pre-text").text + # Extracting the evidence type + evidence = other_source.find("Other-source_post-text").text + evidence = evidence.split(": ")[1] + # Adding the extracted information to the list + assoc = Association( + subject=subject, + subject_label=gene_symbol, + predicate=predicate, + object=go_id, + object_label=go_label, + evidence_type=evidence, + # property_values=[evidence_obj], + publications=list(pmids), + ) + yield assoc + + def basic_search( + self, search_term: str, config: Optional[SearchConfiguration] = None + ) -> Iterable[CURIE]: + search_params = { + "db": "gene", # Database to search in + "term": search_term, # Gene name or symbol to search for + "retmode": "json", # Return mode + "retmax": "10", # Number of results to return (adjust as needed) + } + + response = requests.get(ESEARCH_URL, params=search_params) + if response.status_code != 200: + raise Exception(f"Failed to search for gene '{search_term}'") + + # Parse the JSON response + result = response.json() + ids = result.get("esearchresult", {}).get("idlist", []) + + for id in ids: + yield f"NCBIGene:{id}" diff --git a/src/oaklib/implementations/uniprot/uniprot_implementation.py b/src/oaklib/implementations/uniprot/uniprot_implementation.py index ceb1da2d5..0918338fe 100644 --- a/src/oaklib/implementations/uniprot/uniprot_implementation.py +++ b/src/oaklib/implementations/uniprot/uniprot_implementation.py @@ -24,6 +24,8 @@ from dataclasses import dataclass from typing import Any, Dict, Iterable, Iterator, List, Optional +import requests + from oaklib.datamodels.association import Association from oaklib.datamodels.vocabulary import OWL_SAME_AS, RDF_SEE_ALSO from oaklib.implementations.sparql.abstract_sparql_implementation import ( @@ -46,6 +48,8 @@ "UniprotImplementation", ] +UNIPROT_API_URL = "https://rest.uniprot.org/uniprotkb" + UNIPROT_PREFIX_MAP = { "up": "http://purl.uniprot.org/core/", "updb": "http://purl.uniprot.org/database/", @@ -134,7 +138,8 @@ def relationships( objects: Iterable[CURIE] = None, include_tbox: bool = True, include_abox: bool = True, - include_entailed: bool = True, + include_entailed: bool = False, + exclude_blank: bool = True, ) -> Iterator[RELATIONSHIP]: """ Uniprot implementation of :ref:`relationships` @@ -198,6 +203,7 @@ def associations( predicate_closure_predicates: Optional[List[PRED_CURIE]] = None, object_closure_predicates: Optional[List[PRED_CURIE]] = None, include_modified: bool = False, + **kwargs, ) -> Iterator[Association]: """ Uniprot implementation of :ref:`associations` @@ -235,6 +241,13 @@ def associations( :param include_modified: not implemented :return: """ + if subjects: + yield from self._associations_via_api( + subjects, + predicates, + objects, + ) + return query = SparqlQuery( select=["?s", "?p", "?o"], where=[ @@ -267,3 +280,103 @@ def associations( pred = self.uri_to_curie(row["p"]["value"]) obj = self.uri_to_curie(row["o"]["value"]) yield Association(subject=subj, predicate=pred, object=obj) + + def _associations_via_api( + self, + subjects: Iterable[CURIE] = None, + predicates: Iterable[PRED_CURIE] = None, + objects: Iterable[CURIE] = None, + property_filter: Dict[PRED_CURIE, Any] = None, + subject_closure_predicates: Optional[List[PRED_CURIE]] = None, + predicate_closure_predicates: Optional[List[PRED_CURIE]] = None, + object_closure_predicates: Optional[List[PRED_CURIE]] = None, + include_modified: bool = False, + add_closure_fields: bool = False, + **kwargs, + ) -> Iterator[Association]: + if not subjects: + raise ValueError("subjects must be specified") + subjects = list(subjects) + for subject in subjects: + acc = subject + if subject.startswith("UniProtKB:"): + acc = subject.split(":")[1] + params = { + "format": "json", + } + response = requests.get(f"{UNIPROT_API_URL}/{acc}", params) + logging.info(f"URL: {response.url}") + if response.status_code != 200: + raise ValueError(f"Could not find {subject}") + data = response.json() + for assoc in self._parse_uniprot_json(subject, data): + yield assoc + + def _parse_uniprot_json( + self, subject: CURIE, data: dict, databases: List[str] = None + ) -> Iterator[Association]: + if not databases: + databases = ["GO", "EC", "KW", "Reactome", "Interpro", "Pfam", "KEGG"] + label_property_by_database = { + "GO": "GoTerm", + "Reactome": "PathwayName", + } + gene_name = data["genes"][0].get("geneName", {}).get("value", None) + for xref in data.get("uniProtKBCrossReferences", []): + # print(xref) + database = xref["database"] + if database not in databases: + continue + # translate list of {key: key, value: value} to dict + props = {x["key"]: x["value"] for x in xref.get("properties", [])} + evidences = [(props.get("GoEvidenceType", None), None)] + if "evidences" in xref: + evidences = [ + (x["evidenceCode"], f'{x["source"]}:{x["id"]}') for x in xref["evidences"] + ] + for evidence_type, pubs in evidences: + object_id = xref["id"] + if ":" not in object_id: + # unbanana + object_id = f"{database}:{object_id}" + object_label = props.get( + label_property_by_database.get(database, "EntryName"), None + ) + if database == "GO": + object_label = object_label[2:] + assoc = Association( + subject=subject, + subject_label=gene_name, + object=object_id, + object_label=object_label, + evidence_type=evidence_type, + publications=pubs, + ) + yield assoc + for comment in data.get("comments", []): + typ = comment.get("commentType", None) + # print(comment) + if typ is None: + continue + if typ == "FUNCTION": + continue + elif typ == "CATALYTIC ACTIVITY": + reaction = comment["reaction"] + if "ecNumber" in reaction: + object_id = f"EC:{reaction['ecNumber']}" + else: + object_id = reaction["reactionCrossReferences"][0]["id"] + object_label = reaction["name"] + evidences = reaction.get("evidences", []) + else: + continue + for evidence in evidences: + assoc = Association( + subject=subject, + subject_label=gene_name, + object=object_id, + object_label=object_label, + evidence_type=evidence["evidenceCode"], + publications=f'{evidence["source"]}:{evidence["id"]}', + ) + yield assoc diff --git a/src/oaklib/interfaces/basic_ontology_interface.py b/src/oaklib/interfaces/basic_ontology_interface.py index 1f45a82e5..c52afb43f 100644 --- a/src/oaklib/interfaces/basic_ontology_interface.py +++ b/src/oaklib/interfaces/basic_ontology_interface.py @@ -31,6 +31,7 @@ from oaklib.types import CATEGORY_CURIE, CURIE, PRED_CURIE, SUBSET_CURIE, URI from oaklib.utilities.basic_utils import get_curie_prefix, pairs_as_dict from oaklib.utilities.iterator_utils import chunk +from oaklib.utilities.keyval_cache import KeyValCache LANGUAGE_TAG = str NC_NAME = str @@ -158,6 +159,8 @@ class BasicOntologyInterface(OntologyInterface, ABC): cache_lookups: bool = False """If True, the implementation may choose to cache lookup operations""" + property_cache: KeyValCache = field(default_factory=lambda: KeyValCache()) + _edge_index: Optional[EdgeIndex] = None _entailed_edge_index: Optional[EdgeIndex] = None diff --git a/src/oaklib/interfaces/dumper_interface.py b/src/oaklib/interfaces/dumper_interface.py index 75aada944..b41606a74 100644 --- a/src/oaklib/interfaces/dumper_interface.py +++ b/src/oaklib/interfaces/dumper_interface.py @@ -22,10 +22,16 @@ "owl": OboGraphToRdfOwlConverter, "turtle": OboGraphToRdfOwlConverter, "rdf": OboGraphToRdfOwlConverter, + "rdfxml": (OboGraphToRdfOwlConverter, {"format": "xml"}), "cx": OboGraphToCXConverter, "obojson": None, } +FORMAT_SYNONYMS = { + "json": "obojson", + "obographs": "obojson", +} + class DumperInterface(BasicOntologyInterface, ABC): """ @@ -47,6 +53,8 @@ def dump( logging.info(f"Dumping graph to {path} in {syntax}") if not syntax: raise ValueError(f"Unknown syntax: {syntax}") + if syntax in FORMAT_SYNONYMS: + syntax = FORMAT_SYNONYMS[syntax] if syntax not in OBOGRAPH_CONVERTERS: raise ValueError(f"Cannot handle syntax: {syntax}") if not isinstance(self, OboGraphInterface): @@ -54,16 +62,20 @@ def dump( og = self.as_obograph() ogdoc = GraphDocument(graphs=[og]) if syntax == "obojson": - json_str = json_dumper.dumps(ogdoc) + json_str = json_dumper.dumps(ogdoc, inject_type=False) if path: with open(path, "w", encoding="utf-8") as f: f.write(json_str) else: print(json_str) else: - converter = OBOGRAPH_CONVERTERS[syntax]() + converter_class = OBOGRAPH_CONVERTERS[syntax] + if isinstance(converter_class, tuple): + converter_class, converter_kwargs = converter_class + kwargs.update(converter_kwargs) + converter = converter_class() converter.enforce_canonical_ordering = enforce_canonical_ordering - logging.info(f"Using {converter}") + logging.info(f"Using {converter}, kwargs={kwargs}") converter.curie_converter = self.converter kwargs = {k: v for k, v in kwargs.items() if v is not None} converter.dump(ogdoc, target=path, **kwargs) diff --git a/src/oaklib/utilities/keyval_cache.py b/src/oaklib/utilities/keyval_cache.py new file mode 100644 index 000000000..5d19390c9 --- /dev/null +++ b/src/oaklib/utilities/keyval_cache.py @@ -0,0 +1,39 @@ +from typing import Any, Dict + +from pydantic import BaseModel + +from oaklib.types import CURIE + + +class KeyValCache(BaseModel): + """ + Key-value cache for storing arbitrary data. + """ + + cache: Dict[str, Dict[str, Any]] = {} + + def add(self, curie: CURIE, property: CURIE, value: Any): + """ + Add a key-value pair to the cache. + """ + if property not in self.cache: + self.cache[property] = {} + self.cache[property][curie] = value + + def get(self, curie: CURIE, property: CURIE) -> Any: + """ + Get a value from the cache. + """ + if property not in self.cache: + return None + if curie not in self.cache[property]: + return None + return self.cache[property][curie] + + def contains(self, curie: CURIE, property: CURIE) -> Any: + """ + Check if a value is in the cache. + """ + if property not in self.cache: + return False + return curie in self.cache[property] diff --git a/src/oaklib/utilities/table_filler.py b/src/oaklib/utilities/table_filler.py index ad3187f0b..c5ab9929c 100644 --- a/src/oaklib/utilities/table_filler.py +++ b/src/oaklib/utilities/table_filler.py @@ -130,7 +130,12 @@ def parse_table(input_file: IO, delimiter="\t") -> List[ROW]: def write_table( - rows: List[ROW], output_file: IO, comments: List[str] = None, delimiter="\t", list_delimiter="|" + rows: List[ROW], + output_file: IO, + comments: List[str] = None, + delimiter="\t", + list_delimiter="|", + header: List[str] = None, ) -> None: """Writes a list of rows to a file, replacing None values with empty strings. @@ -144,7 +149,14 @@ def write_table( for comment in comments: output_file.write(comment) - cols = list(rows[0].keys()) + if header: + cols = header + else: + cols = [] + for row in rows: + for col in row.keys(): + if col not in cols: + cols.append(col) writer = csv.DictWriter(output_file, fieldnames=cols, delimiter=delimiter) writer.writeheader() for row in rows: diff --git a/tests/input/ncbigene-1956.xml b/tests/input/ncbigene-1956.xml new file mode 100644 index 000000000..ab81965ee --- /dev/null +++ b/tests/input/ncbigene-1956.xml @@ -0,0 +1,635814 @@ + + + + + + + 1956 + 0 + + + + + 1992 + 12 + 3 + + + + + + + + + 2023 + 11 + 14 + 20 + 34 + 0 + + + + + + + 6 + + + 1 + 1 + + + Homo sapiens + human + + + taxon + + + 9606 + + + + + + + + + + Homo + sapiens + + + + specified + Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo + 1 + 2 + PRI + + + + + + + 1 + 7 + + + + + + + EGFR + epidermal growth factor receptor + 7p11.2 + + + HGNC + + + HGNC:3236 + + + + + Ensembl + + + ENSG00000146648 + + + + + MIM + + + 131550 + + + + + AllianceGenome + + + HGNC:3236 + + + + + + ERBB + ERRP + HER1 + mENA + ERBB1 + PIG61 + NISBD2 + + + + + + + EGFR vIII + avian erythroblastic leukemia viral (v-erb-b) oncogene homolog + cell growth inhibiting protein 40 + cell proliferation-inducing protein 61 + epidermal growth factor receptor tyrosine kinase domain + erb-b2 receptor tyrosine kinase 1 + proto-oncogene c-ErbB-1 + receptor tyrosine-protein kinase erbB-1 + + epidermal growth factor receptor + + + The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] + + + 7p11.2 + + + + + + + + LocusLink + 1956 + 1956 + + + + + 1 + Reference GRCh38.p14 Primary Assembly + Chromosome 7 Reference GRCh38.p14 Primary Assembly + NC_000007 + 14 + + + + + 55019016 + 55211627 + + + + + + 568815591 + + + + + + + + + 3 + Reference + transcript variant 1 + NM_005228 + 5 + + + + + + + + 55019016 + 55019364 + + + + + + 568815591 + + + + + + + + + 55142285 + 55142436 + + + + + + 568815591 + + + + + + + + + 55143304 + 55143487 + + + + + + 568815591 + + + + + + + + + 55146605 + 55146739 + + + + + + 568815591 + + + + + + + + + 55151293 + 55151361 + + + + + + 568815591 + + + + + + + + + 55152545 + 55152663 + + + + + + 568815591 + + + + + + + + + 55154010 + 55154151 + + + + + + 568815591 + + + + + + + + + 55155829 + 55155945 + + + + + + 568815591 + + + + + + + + + 55156532 + 55156658 + + + + + + 568815591 + + + + + + + + + 55156758 + 55156831 + + + + + + 568815591 + + + + + + + + + 55157662 + 55157752 + + + + + + 568815591 + + + + + + + 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+ + + + + ClinGen Genome Curation Page + https://www.ncbi.nlm.nih.gov/projects/dbvar/ISCA/isca_gene.cgi?sym=EGFR + + + + + + + 19 + Cetuximab response + + + 19 + GTR + + + + + GTRDisease + + + CN077967 + + + + + Genetic Testing Registry + + + + + 19 + MedGen + + + + + MedGen + + + CN077967 + + + + + MedGen + + + + + + + 19 + Chromosome 7p11.2 (EGFR) variation influences glioma risk. + + + 19 + EBI GWAS Catalog + + + + 21531791 + + + + + + EBI GWAS Catalog + https://www.ebi.ac.uk/gwas/publications/21531791 + + + + + + + 19 + Inflammatory skin and bowel disease, neonatal, 2 + + + 19 + GTR + + + + + GTRDisease + + + C4015130 + + + + + Genetic Testing Registry + + + + + 19 + MedGen + + + + + MedGen + + + C4015130 + + + + + MedGen + + + + + 19 + OMIM + + + + + MIM + + + 616069 + + + + + MIM: 616069 + + + + + + + 19 + Lung cancer + + + 19 + GTR + + + + + GTRDisease + + + C0242379 + + + + + Genetic Testing Registry + + + + + 19 + MedGen + + + + + MedGen + + + C0242379 + + + + + MedGen + + + + + 19 + OMIM + + + + + MIM + + + 211980 + + + + + MIM: 211980 + + + + + + + 19 + Panitumumab response + + + 19 + GTR + + + + + GTRDisease + + + CN077999 + + + + + Genetic Testing Registry + + + + + 19 + MedGen + + + + + MedGen + + + CN077999 + + + + + MedGen + + + + + + + + + 254 + NCBI Reference Sequences (RefSeq) + + + 254 + RefSeqs maintained independently of Annotated Genomes + + + 3 + mRNA Sequence + NM_001346897 + 2 + + + + + Nucleotide + + + 1676319802 + + + + + NM_001346897 + + + + + + + 1676319802 + + + + + + + 8 + Product + NP_001333826 + 1 + + + + + Protein + + + 1100818972 + + + + + NP_001333826 + epidermal growth factor receptor isoform e precursor + + + + + + + 1100818972 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000415559.1 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + F2YGG7 + + + + + F2YGG7 + + + + + UniProtKB/TrEMBL + + + Q504U8 + + + + + Q504U8 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS87507.1 + + + + + CCDS87507.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus compared to isoform a. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324,BC094761 + + + + + AC006977,AC073324,BC094761 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000455089.5 + + + + + + + + + + + 3 + mRNA Sequence + NM_001346898 + 2 + + + + + Nucleotide + + + 1674985904 + + + + + NM_001346898 + + + + + + + 1674985904 + + + + + + + 8 + Product + NP_001333827 + 1 + + + + + Protein + + + 1100832916 + + + + + NP_001333827 + epidermal growth factor receptor isoform f precursor + + + + + + + 1100832916 + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + A9CB80 + + + + + A9CB80 + + + + + UniProtKB/TrEMBL + + + E7BSV0 + + + + + E7BSV0 + + + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (6) has a 3' terminal exon that extends past a splice site that is used in variant 1. The encoded isoform (f) has a shorter and distinct C-terminus compared to isoform a. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324,BC094761,GU255993,HQ912715 + + + + + AC006977,AC073324,BC094761,GU255993,HQ912715 + + + + + + + 3 + mRNA Sequence + NM_001346899 + 2 + + + + + Nucleotide + + + 1890245545 + + + + + NM_001346899 + + + + + + + 1890245545 + + + + + + + 8 + Product + NP_001333828 + 1 + + + + + Protein + + + 1100818974 + + + + + NP_001333828 + epidermal growth factor receptor isoform g precursor + + + + + + + 1100818974 + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + F2YGG7 + + + + + F2YGG7 + + + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324,AW450657,BC094761,DA371223,HQ912715 + + + + + AC006977,AC073324,AW450657,BC094761,DA371223,HQ912715 + + + + + + + 3 + mRNA Sequence + NM_001346900 + 2 + + + + + Nucleotide + + + 1676318675 + + + + + NM_001346900 + + + + + + + 1676318675 + + + + + + + 8 + Product + NP_001333829 + 1 + + + + + Protein + + + 1100818978 + + + + + NP_001333829 + epidermal growth factor receptor isoform h + + + + + + + 1100818978 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000413354.2 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + B7Z2I3 + + + + + B7Z2I3 + + + + + UniProtKB/TrEMBL + + + C9JYS6 + + + + + C9JYS6 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS94105.1 + + + + + CCDS94105.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (8) uses a novel 5' terminal exon compared to variant 1. The encoded isoform (h) has a shorter and distinct N-terminus compared to isoform a. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324,AK294750,AW450657,DA371223,DC347326,HQ912715 + + + + + AC006977,AC073324,AK294750,AW450657,DA371223,DC347326,HQ912715 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000450046.2 + + + + + + + + + + + 3 + mRNA Sequence + NM_001346941 + 2 + + + + + Nucleotide + + + 1675033261 + + + + + NM_001346941 + + + + + + + 1675033261 + + + + + + + 8 + Product + NP_001333870 + 1 + + + + + Protein + + + 1101020101 + + + + + NP_001333870 + epidermal growth factor receptor isoform i precursor + + + + + + + 1101020101 + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + Q59FL8 + + + + + Q59FL8 + + + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (EGFRvIII, also known as delta-EGFR and de2-7EGFR) has an in-frame deletion of six exons in the 5' coding region, compared to variant 1. The encoded isoform (i) has a shorter extracellular domain compared to isoform a. This variant is considered to be tumorigenic and the encoded protein lacks normal ligand binding ability and is constitutively active (PMID: 23777544). + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324 + + + + + AC006977,AC073324 + + + + + + + 3 + mRNA Sequence + NM_005228 + 5 + + + + + Nucleotide + + + 1519245592 + + + + + NM_005228 + + + + + + + 1519245592 + + + + + + + 8 + Product + NP_005219 + 2 + + + + + Protein + + + 29725609 + + + + + NP_005219 + epidermal growth factor receptor isoform a precursor + + + + + + + 29725609 + + + + + + + 255 + Conserved Domains + + + (10) + summary + + + + + 255 + + + + + CDD + + + 197581 + + + + + smart00219: TyrKc; Tyrosine kinase, catalytic domain + + + + + 255 + Location: 713 - 968 + + + + + 255 + + + + + CDD + + + 213054 + + + + + cd12093: TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase + + + + + 255 + Location: 634 - 677 + + + + + 255 + + + + + CDD + + + 214589 + + + + + smart00261: FU; Furin-like repeats + + + + + 255 + Location: 552 - 598 + + + + + 255 + + + + + CDD + + + 238021 + + + + + cd00064: FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. + + + + + 255 + Location: 231 - 274 + + + 255 + Location: 506 - 559 + + + + + 255 + + + + + CDD + + + 270683 + + + + + cd05108: PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor + + + + + 255 + Location: 704 - 1016 + + + + + 255 + + + + + CDD + + + 279142 + + + + + pfam00757: Furin-like; Furin-like cysteine rich region + + + + + 255 + Location: 185 - 335 + + + + + 255 + + + + + CDD + + + 279382 + + + + + pfam01030: Recep_L_domain; Receptor L domain + + + + + 255 + Location: 57 - 168 + + + 255 + Location: 361 - 481 + + + + + 255 + + + + + CDD + + + 291509 + + + + + pfam14843: GF_recep_IV; Growth factor receptor domain IV + + + + + 255 + Location: 505 - 637 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000275493.2 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + A9CB80 + + + + + A9CB80 + + + + + UniProtKB/Swiss-Prot + + + O00688 + + + + + O00688 + + + + + UniProtKB/Swiss-Prot + + + O00732 + + + + + O00732 + + + + + UniProtKB/Swiss-Prot + + + P00533 + + + + + P00533 + + + + + UniProtKB/Swiss-Prot + + + P06268 + + + + + P06268 + + + + + UniProtKB/Swiss-Prot + + + Q14225 + + + + + Q14225 + + + + + UniProtKB/TrEMBL + + + Q2TTR7 + + + + + Q2TTR7 + + + + + UniProtKB/Swiss-Prot + + + Q68GS5 + + + + + Q68GS5 + + + + + UniProtKB/Swiss-Prot + + + Q92795 + + + + + Q92795 + + + + + UniProtKB/Swiss-Prot + + + Q9BZS2 + + + + + Q9BZS2 + + + + + UniProtKB/Swiss-Prot + + + Q9GZX1 + + + + + Q9GZX1 + + + + + UniProtKB/Swiss-Prot + + + Q9H2C9 + + + + + Q9H2C9 + + + + + UniProtKB/Swiss-Prot + + + Q9H3C9 + + + + + Q9H3C9 + + + + + UniProtKB/Swiss-Prot + + + Q9UMD7 + + + + + Q9UMD7 + + + + + UniProtKB/Swiss-Prot + + + Q9UMD8 + + + + + Q9UMD8 + + + + + UniProtKB/Swiss-Prot + + + Q9UMG5 + + + + + Q9UMG5 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS5514.1 + + + + + CCDS5514.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (1) encodes the longest isoform (a). + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AC073324,AF125253,AU137334,AW450657,BC094761,DA371223,HQ912715,X00588 + + + + + AC006977,AC073324,AF125253,AU137334,AW450657,BC094761,DA371223,HQ912715,X00588 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000275493.7 + + + + + + + + + + + 3 + mRNA Sequence + NM_201282 + 2 + + + + + Nucleotide + + + 1676319062 + + + + + NM_201282 + + + + + + + 1676319062 + + + + + + + 8 + Product + NP_958439 + 1 + + + + + Protein + + + 41327732 + + + + + NP_958439 + epidermal growth factor receptor isoform b precursor + + + + + + + 41327732 + + + + + + + 255 + Conserved Domains + + + (7) + summary + + + + + 255 + + + + + CDD + + + 214589 + + + + + smart00261: FU; Furin-like repeats + + + + + 255 + Location: 552 - 598 + + + + + 255 + + + + + CDD + + + 238021 + + + + + cd00064: FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. + + + + + 255 + Location: 231 - 274 + + + 255 + Location: 506 - 559 + + + + + 255 + + + + + CDD + + + 279142 + + + + + pfam00757: Furin-like; Furin-like cysteine rich region + + + + + 255 + Location: 185 - 335 + + + + + 255 + + + + + CDD + + + 279382 + + + + + pfam01030: Recep_L_domain; Receptor L domain + + + + + 255 + Location: 57 - 168 + + + 255 + Location: 361 - 481 + + + + + 255 + + + + + CDD + + + 291509 + + + + + pfam14843: GF_recep_IV; Growth factor receptor domain IV + + + + + 255 + Location: 505 - 627 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000342376.3 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + Q68GS6 + + + + + Q68GS6 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS5516.1 + + + + + CCDS5516.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (2) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform b. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AF125253,AF277897,AW163038,X00588 + + + + + AC006977,AF125253,AF277897,AW163038,X00588 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000342916.7 + + + + + + + + + + + 3 + mRNA Sequence + NM_201283 + 2 + + + + + Nucleotide + + + 1890270827 + + + + + NM_201283 + + + + + + + 1890270827 + + + + + + + 8 + Product + NP_958440 + 1 + + + + + Protein + + + 41327734 + + + + + NP_958440 + epidermal growth factor receptor isoform c precursor + + + + + + + 41327734 + + + + + + + 255 + Conserved Domains + + + (4) + summary + + + + + 255 + + + + + CDD + + + 238021 + + + + + cd00064: FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. + + + + + 255 + Location: 231 - 274 + + + + + 255 + + + + + CDD + + + 279142 + + + + + pfam00757: Furin-like; Furin-like cysteine rich region + + + + + 255 + Location: 185 - 335 + + + + + 255 + + + + + CDD + + + 279382 + + + + + pfam01030: Recep_L_domain; Receptor L domain + + + + + 255 + Location: 57 - 168 + + + 255 + Location: 361 - 403 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000413843.2 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/Swiss-Prot + + + P00533 + + + + + P00533 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS47587.1 + + + + + CCDS47587.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (3, also known as ErbB1-S) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform c. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AW163038,U48722,X00588 + + + + + AC006977,AW163038,U48722,X00588 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000420316.6 + + + + + + + + + + + 3 + mRNA Sequence + NM_201284 + 2 + + + + + Nucleotide + + + 1675049307 + + + + + NM_201284 + + + + + + + 1675049307 + + + + + + + 8 + Product + NP_958441 + 1 + + + + + Protein + + + 41327736 + + + + + NP_958441 + epidermal growth factor receptor isoform d precursor + + + + + + + 41327736 + + + + + + + 255 + Conserved Domains + + + (7) + summary + + + + + 255 + + + + + CDD + + + 214589 + + + + + smart00261: FU; Furin-like repeats + + + + + 255 + Location: 552 - 598 + + + + + 255 + + + + + CDD + + + 238021 + + + + + cd00064: FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. + + + + + 255 + Location: 231 - 274 + + + 255 + Location: 506 - 559 + + + + + 255 + + + + + CDD + + + 279142 + + + + + pfam00757: Furin-like; Furin-like cysteine rich region + + + + + 255 + Location: 185 - 335 + + + + + 255 + + + + + CDD + + + 279382 + + + + + pfam01030: Recep_L_domain; Receptor L domain + + + + + 255 + Location: 57 - 168 + + + 255 + Location: 361 - 481 + + + + + 255 + + + + + CDD + + + 291509 + + + + + pfam14843: GF_recep_IV; Growth factor receptor domain IV + + + + + 255 + Location: 505 - 627 + + + + + + + 255 + Related + + + + + Ensembl + + + ENSP00000345973.2 + + + + + + + + + 255 + UniProtKB + + + + 255 + + + + + UniProtKB/TrEMBL + + + Q68GS6 + + + + + Q68GS6 + + + + + + + 255 + Consensus CDS (CCDS) + + + + + CCDS + + + CCDS5515.1 + + + + + CCDS5515.1 + + + + + + + + + 254 + RefSeq Status + REVIEWED + + + 254 + Transcriptional Variant + + + 254 + Transcript Variant: This variant (4) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform d. + + + + + 255 + Source Sequence + + + + + Nucleotide + + + AC006977,AF125253,AW163038,X00588 + + + + + AC006977,AF125253,AW163038,X00588 + + + + + 255 + Related + + + + + Ensembl + + + ENST00000344576.7 + + + + + + + + + + + + + 1 + RefSeqGene + NG_007726 + 3 + + + + + Nucleotide + + + 399923581 + + + + + NG_007726 + + + + + LRG + + + LRG_304 + + + + + LRG_304 + + + + + + + 5000 + 193306 + + + + + + 399923581 + + + + + + + + + + + 254 + RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10 + + + 1 + Reference GRCh38.p14 Primary Assembly + NC_000007 + 14 + + + + + Nucleotide + + + 568815591 + + + + + + + + + + + 55019016 + 55211627 + + + + + + 568815591 + + + + + + + + + 3 + XM_047419953 + 1 + + + + + Nucleotide + + + 2217365843 + + + + + + + + + + + 2217365843 + + + + + + + 8 + XP_047275909 + 1 + + + + + Protein + + + 2217365844 + + + + + XP_047275909 + epidermal growth factor receptor isoform X1 + + + + + + + 2217365844 + + + 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11 + 56 + 0 + + + + + + + + + 2023 + 11 + 1 + 20 + 38 + 0 + + + + + + + 18 + RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer. + + + + 37853459 + + + + + + + + 2023 + 10 + 30 + 14 + 46 + 0 + + + + + + + + + 2023 + 10 + 30 + 20 + 34 + 0 + + + + + + + 18 + VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer. + + + + 36738481 + + + + + + + + 2023 + 10 + 28 + 13 + 6 + 0 + + + + + + + + + 2023 + 10 + 28 + 20 + 35 + 0 + + + + + + + 18 + Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer. + + + + 37783120 + + + + + + + + 2023 + 10 + 13 + 10 + 17 + 0 + + + + + + + + + 2023 + 10 + 13 + 20 + 37 + 0 + + + + + + + 18 + Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex. + + + + 37442582 + + + + + + + + 2023 + 10 + 11 + 15 + 46 + 0 + + + + + + + + + 2023 + 10 + 11 + 20 + 31 + 0 + + + + + + + 18 + microRNA-143 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Therapeutic Response in African American Patients With Non-Small-Cell Lung Cancer. + + + + 37625101 + + + + + + + + 2023 + 9 + 12 + 11 + 51 + 0 + + + + + + + + + 2023 + 9 + 12 + 20 + 36 + 0 + + + + + + + 18 + IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m[6]A-dependent manner. + + + + 37658049 + + + + + + + + 2023 + 9 + 11 + 7 + 24 + 0 + + + + + + + + + 2023 + 9 + 11 + 20 + 36 + 0 + + + + + + + 18 + [Clinical characteristics and their influences on the survival of leptomeningeal metastasis derived from lung adenocarcinoma harboring epithelial growth factor receptor mutation]. + + + + 37675543 + + + + + + + + 2023 + 9 + 8 + 12 + 43 + 0 + + + + + + + + + 2023 + 9 + 8 + 20 + 42 + 0 + + + + + + + 18 + Osteoblastic bone reaction in non-small cell lung cancer harboring epidermal growth factor receptor mutation treated with osimertinib. + + + + 37674153 + + + + + + + + 2023 + 9 + 8 + 12 + 9 + 0 + + + + + + + + + 2023 + 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the EGFR mutation on thoracic spinal metastases from lung cancer. + + + + 34633298 + + + + + + + + 2022 + 4 + 23 + 10 + 2 + 0 + + + + + + + + + 2022 + 4 + 23 + 11 + 18 + 0 + + + + + + + 18 + The clinicopathological and molecular characteristics of resected EGFR-mutant lung adenocarcinoma. + + + + 35023616 + + + + + + + + 2022 + 4 + 23 + 10 + 2 + 0 + + + + + + + + + 2022 + 4 + 23 + 11 + 15 + 0 + + + + + + + 18 + GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation. + + + + 35220009 + + + + + + + + 2022 + 4 + 23 + 10 + 2 + 0 + + + + + + + + + 2022 + 4 + 23 + 11 + 14 + 0 + + + + + + + 18 + T-box transcription factor 19 promotes hepatocellular carcinoma metastasis through upregulating EGFR and RAC1. + + + + 35217793 + + + + + + + + 2022 + 4 + 23 + 10 + 2 + 0 + + + + + + + + + 2022 + 4 + 23 + 11 + 14 + 0 + + + + + + + 18 + Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes. + + + + 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Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFR(Y1086) Phosphorylation. + + + + 35208960 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 11 + 0 + + + + + + + 18 + Co-occurrence CDK4/6 amplification serves as biomarkers of de novo EGFR TKI resistance in sensitizing EGFR mutation non-small cell lung cancer. + + + + 35140316 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 9 + 0 + + + + + + + 18 + Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis. + + + + 34610265 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 6 + 0 + + + + + + + 18 + Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer. + + + + 34319535 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 3 + 0 + + + + + + + 18 + T790M-EGFR mutation frequency in advanced NSCLC patients on progression from a previous TKI therapy: results from a Portuguese study. + + + + 34172423 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 2 + 0 + + + + + + + 18 + Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma. + + + + 33473104 + + + + + + + + 2022 + 3 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 3 + 5 + 11 + 1 + 0 + + + + + + + 18 + CK1delta stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer. + + + + 34709767 + + + + + + + + 2022 + 2 + 26 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 26 + 11 + 7 + 0 + + + + + + + 18 + EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression. + + + + 34620174 + + + + + + + + 2022 + 2 + 26 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 26 + 11 + 6 + 0 + + + + + + + 18 + O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR. + + + + 32776095 + + + + + + + + 2022 + 2 + 26 + 10 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12 + 11 + 33 + 0 + + + + + + + 18 + EGFR mutational landscape in nasopharyngeal carcinoma. + + + + 34077017 + + + + + + + + 2022 + 2 + 12 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 12 + 11 + 27 + 0 + + + + + + + 18 + Body Mass Index, Weight Loss, and Mortality Risk in Advanced-Stage Non-Small Cell Lung Cancer Patients: A Focus on EGFR Mutation. + + + + 34836017 + + + + + + + + 2022 + 2 + 12 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 12 + 11 + 25 + 0 + + + + + + + 18 + Comprehensive analysis of NGS and ARMS-PCR for detecting EGFR mutations based on 4467 cases of NSCLC patients. + + + + 34693477 + + + + + + + + 2022 + 2 + 12 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 12 + 11 + 23 + 0 + + + + + + + 18 + Phosphorylated EGFR (pEGFR T693) as a Novel Predictor of Recurrence in Non-Functioning Pituitary Adenomas. + + + + 34295309 + + + + + + + + 2022 + 2 + 12 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 12 + 11 + 23 + 0 + + + + + + + 18 + B-cell clonogenic activity of HIV-1 p17 variants is driven by 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Survival in Laryngeal Carcinoma. + + + + 33758141 + + + + + + + + 2022 + 2 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 5 + 11 + 21 + 0 + + + + + + + 18 + STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma. + + + + 34741044 + + + + + + + + 2022 + 2 + 5 + 10 + 2 + 0 + + + + + + + + + 2022 + 2 + 5 + 11 + 18 + 0 + + + + + + + 18 + NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer. + + + + 34385595 + + + + + + + + 2022 + 1 + 29 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 29 + 11 + 16 + 0 + + + + + + + 18 + Topomer-CoMFA proposed as a tool to construct dual EGFR/HER-2 models. + + + + 34363097 + + + + + + + + 2022 + 1 + 29 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 29 + 11 + 15 + 0 + + + + + + + 18 + Comparative clinical outcomes for patients with advanced NSCLC harboring EGFR exon 20 insertion mutations and common EGFR mutations. + + + + 34818606 + + 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Druggable Gene Mutations in Melanoma, Breast, Lung, and Thyroid Cancers. + + + + 34906047 + + + + + + + + 2022 + 1 + 22 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 22 + 11 + 6 + 0 + + + + + + + 18 + Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells. + + + + 33340661 + + + + + + + + 2022 + 1 + 22 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 22 + 11 + 5 + 0 + + + + + + + 18 + EGFR-rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway-suppressed ROS. + + + + 33304472 + + + + + + + + 2022 + 1 + 22 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 22 + 11 + 5 + 0 + + + + + + + 18 + Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer. + + + + 33158848 + + + + + + + + 2022 + 1 + 22 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 22 + 11 + 4 + 0 + + + + + + + 18 + A Rare Presentation of a Non-Asian Female With Metastatic Non-small-cell Lung Cancer Harboring EGFR L747P Mutation With Clinical Response to Multi-targeted Epigenetic and EGFR Inhibition. + + + + 34969754 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 22 + 0 + + + + + + + 18 + Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor. + + + + 34948100 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 22 + 0 + + + + + + + 18 + EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor. + + + + 34884742 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 21 + 0 + + + + + + + 18 + Predictive value of EGFR mutation in non-small-cell lung cancer patients treated with platinum doublet postoperative chemotherapy. + + + + 34689382 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 19 + 0 + + + + + + + 18 + CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. + + + + 34187934 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 18 + 0 + + + + + + + 18 + ALCAM-EGFR interaction regulates myelomagenesis. + + + + 34592762 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 17 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) mutation testing is useful for primary lung cancer diagnosis and appropriate surgical resection: A case series. + + + + 34544656 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 15 + 11 + 16 + 0 + + + + + + + 18 + Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D. + + + + 33888812 + + + + + + + + 2022 + 1 + 15 + 10 + 2 + 0 + + + + + + + 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invasion involves the EGFR ligand amphiregulin. + + + + 34843542 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 25 + 0 + + + + + + + 18 + Mutation Spectrum of EGFR From 21,324 Chinese Patients With Non-Small Cell Lung Cancer (NSCLC) Successfully Tested by Multiple Methods in a CAP-Accredited Laboratory. + + + + 34257561 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 22 + 0 + + + + + + + 18 + EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma. + + + + 34257550 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 22 + 0 + + + + + + + 18 + Long noncoding RNA lnc-LEMGC combines with DNA-PKcs to suppress gastric cancer metastasis. + + + + 34626692 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 20 + 0 + + + + + + + 18 + Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer. + + + + 34599295 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 20 + 0 + + + + + + + 18 + METTL3 induces PLX4032 resistance in melanoma by promoting m(6)A-dependent EGFR translation. + + + + 34530048 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 19 + 0 + + + + + + + 18 + Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer. + + + + 34098062 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 16 + 0 + + + + + + + 18 + STAT3 mediated upregulation of C-MET signaling acts as a compensatory survival mechanism upon EGFR family inhibition in chemoresistant breast cancer cells. + + + + 34348188 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 13 + 0 + + + + + + + 18 + DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals. + + + + 34320372 + + + + + + + + 2022 + 1 + 8 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 8 + 11 + 13 + 0 + + + + + + + 18 + MASTL regulates EGFR signaling to impact pancreatic cancer progression. + + + + 34331012 + + + + + + + + 2022 + 1 + 1 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 1 + 11 + 20 + 0 + + + + + + + 18 + Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling. + + + + 34916513 + + + + + + + + 2022 + 1 + 1 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 1 + 11 + 19 + 0 + + + + + + + 18 + ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling. + + + + 34556814 + + + + + + + + 2022 + 1 + 1 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 1 + 11 + 16 + 0 + + + + + + + 18 + Genotype-determined EGFR-RTK heterodimerization and its effects on drug resistance in lung Cancer treatment revealed by molecular dynamics simulations. + + + + 34112110 + + + + + + + + 2022 + 1 + 1 + 10 + 2 + 0 + + + + + + + + + 2022 + 1 + 1 + 11 + 15 + 0 + + + + + + + 18 + The Allele Frequency of EGFR Mutations Predicts Survival in Advanced EGFR T790M-Positive Non-small Cell Lung Cancer Patients Treated with Osimertinib. + + + + 33270169 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 11 + 0 + + + + + + + 18 + Non-small cell lung cancer in the very young: Higher EGFR/ALK mutation proportion than the elder. + + + + 32221155 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 11 + 0 + + + + + + + 18 + GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling. + + + + 34023418 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 11 + 0 + + + + + + + 18 + MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma. + + + + 33980265 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 10 + 0 + + + + + + + 18 + NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization. + + + + 34613794 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 10 + 0 + + + + + + + 18 + Validation of a next-generation sequencing assay for the detection of EGFR mutations in cell-free circulating tumor DNA. + + + + 34560086 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 10 + 0 + + + + + + + 18 + TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways. + + + + 32535744 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 5 + 0 + + + + + + + 18 + [Hypomethylation of DAPL1 associated with prognosis of lung cancer patients with EGFR Del19 mutation]. + + + + 34915634 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 5 + 0 + + + + + + + 18 + [Differences between EGFR Exon 19 Deletion and Exon 21 L858R Point Mutation, Frequently Detected EGFR Mutations in Patients with Non-Small Cell Lung Cancer, from a Molecular Biology Viewpoint]. + + + + 34911913 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 5 + 0 + + + + + + + 18 + ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCiota. + + + + 34830169 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 4 + 0 + + + + + + + 18 + WSG, a glucose-enriched polysaccharide from Ganoderma lucidum, suppresses tongue cancer cells via inhibition of EGFR-mediated signaling and potentiates cisplatin-induced apoptosis. + + + + 34742847 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 25 + 11 + 1 + 0 + + + + + + + 18 + Treatment strategy optimization for patients with non-small-cell lung cancer harboring EGFR mutation: a Delphi consensus. + + + + 33210237 + + + + + + + + 2021 + 12 + 25 + 10 + 2 + 0 + + + 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18 + 11 + 8 + 0 + + + + + + + 18 + Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. + + + + 34830467 + + + + + + + + 2021 + 12 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 18 + 11 + 7 + 0 + + + + + + + 18 + Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands. + + + + 34830377 + + + + + + + + 2021 + 12 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 18 + 11 + 7 + 0 + + + + + + + 18 + Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. + + + + 34830108 + + + + + + + + 2021 + 12 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 18 + 11 + 7 + 0 + + + + + + + 18 + Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer. + + + + 34769263 + + + + + + + + 2021 + 12 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 12 + 18 + 11 + 4 + 0 + + + + + + + 18 + IL13Ralpha2 and EGFRtargeted pseudomonas exotoxin potentiates the TRAILmediated death of GBM cells. + + + + 34080646 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 24 + 0 + + + + + + + 18 + Epidermal growth factor receptor association with beta1-adrenergic receptor is mediated via its juxtamembrane domain. + + + + 33238186 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 21 + 0 + + + + + + + 18 + LncRNA TSLNC8 synergizes with EGFR inhibitor osimertinib to inhibit lung cancer tumorigenesis by blocking the EGFR-STAT3 pathway. + + + + 33064977 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 20 + 0 + + + + + + + 18 + G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor. + + + + 34609770 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 18 + 0 + + + + + + + 18 + Computed Tomography Imaging Characteristics: Potential Indicators of Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinoma. + + + + 34581708 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 16 + 0 + + + + + + + 18 + EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis. + + + + 34550317 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 16 + 0 + + + + + + + 18 + EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions. + + + + 34515735 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 15 + 0 + + + + + + + 18 + Prolonged cetuximab treatment promotes p27(Kip1)-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma. + + + + 33664437 + + + + + + + + 2021 + 12 + 11 + 10 + 3 + 0 + + + + + + + + + 2021 + 12 + 11 + 11 + 12 + 0 + + + + + + + 18 + Value of CT features for predicting EGFR mutations and ALK positivity in patients with lung adenocarcinoma. + + + + 33707479 + + + + + + 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27 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 27 + 11 + 16 + 0 + + + + + + + 18 + Reduced kinase Dinteracting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression. + + + + 33955519 + + + + + + + + 2021 + 11 + 27 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 27 + 11 + 15 + 0 + + + + + + + 18 + [Analysis of the Efficacy of Immunotherapy on the Posterior Lines of Advanced EGFR Mutant Patients with Non-small cell Lung Cancer]. + + + + 34034457 + + + + + + + + 2021 + 11 + 20 + 10 + 4 + 0 + + + + + + + + + 2021 + 11 + 22 + 16 + 33 + 0 + + + + + + + 18 + [Analysis of the Relationship Between the Quality of Small Biopsy Specimens of Non-small Cell Lung Cancer and the Mutation Rate of EGFR Gene]. + + + + 34034456 + + + + + + + + 2021 + 11 + 20 + 10 + 4 + 0 + + + + + + + + + 2021 + 11 + 22 + 16 + 33 + 0 + + + + + + + 18 + ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial-mesenchymal 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11 + 22 + 16 + 24 + 0 + + + + + + + 18 + Exploring the role of epidermal growth factor receptor variant III in meningeal tumors. + + + + 34582442 + + + + + + + + 2021 + 11 + 20 + 10 + 4 + 0 + + + + + + + + + 2021 + 11 + 22 + 16 + 23 + 0 + + + + + + + 18 + Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition. + + + + 33159968 + + + + + + + + 2021 + 11 + 20 + 10 + 4 + 0 + + + + + + + + + 2021 + 11 + 22 + 16 + 22 + 0 + + + + + + + 18 + Altered expression of EGFR and miR-34a derived from serum and tumoral tissue was associated with glioblastoma multiform. + + + + 34062187 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 30 + 0 + + + + + + + 18 + PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients: a Danish cohort study. + + + + 34413420 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 26 + 0 + + + + + + + 18 + Circulating tumor DNA sequencing in colorectal cancer patients treated with first-line chemotherapy with anti-EGFR. + + + + 34381078 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 25 + 0 + + + + + + + 18 + Comparison of the outcome between immunotherapy alone or in combination with chemotherapy in EGFR-mutant non-small cell lung cancer. + + + + 34373555 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 25 + 0 + + + + + + + 18 + ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells. + + + + 33203722 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 22 + 0 + + + + + + + 18 + The Frequency of Epidermal Growth Factor Receptor (EGFR) mutations in Iraqi patients with Non-Small Cell Lung Cancer (NSCLC). + + + + 33639678 + + + + + + + + 2021 + 11 + 13 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 13 + 11 + 20 + 0 + + + + + + + 18 + K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR. + + + + 34117217 + + + + + + + + 2021 + 11 + 6 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 6 + 11 + 18 + 0 + + + + + + + 18 + Analysis of EGFR Mutation Status in Algerian Patients with Non-Small Cell Lung Cancer. + + + + 33906297 + + + + + + + + 2021 + 11 + 6 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 6 + 11 + 16 + 0 + + + + + + + 18 + FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth. + + + + 34635651 + + + + + + + + 2021 + 11 + 6 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 6 + 11 + 14 + 0 + + + + + + + 18 + The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-alpha Gene Polymorphisms in Metal Industrial Workers and General Population. + + + + 34501555 + + + + + + + + 2021 + 11 + 6 + 10 + 2 + 0 + + + + + + + + + 2021 + 11 + 6 + 11 + 12 + 0 + + + + + + + 18 + The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma. + + + + 34487971 + + + + + + + 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through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. + + + + 34576152 + + + + + + + + 2021 + 10 + 23 + 10 + 2 + 0 + + + + + + + + + 2021 + 10 + 23 + 11 + 12 + 0 + + + + + + + 18 + Osteopontin improves sensitivity to tyrosine kinase inhibitor in lung adenocarcinoma in vitro by promoting epidermal growth factor receptor phosphorylation. + + + + 34255150 + + + + + + + + 2021 + 10 + 23 + 10 + 2 + 0 + + + + + + + + + 2021 + 10 + 23 + 11 + 9 + 0 + + + + + + + 18 + Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-alpha Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo. + + + + 34130299 + + + + + + + + 2021 + 10 + 23 + 10 + 2 + 0 + + + + + + + + + 2021 + 10 + 23 + 11 + 8 + 0 + + + + + + + 18 + The impact of different first-line EGFR-TKIs on the clinical outcome of sequential osimertinib treatment in advanced NSCLC with secondary T790M. + + + + 34103652 + + + + + + + + 2021 + 10 + 23 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Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer. + + + + 34521849 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 39 + 0 + + + + + + + 18 + Foxq1 promotes metastasis of nasopharyngeal carcinoma by inducing vasculogenic mimicry via the EGFR signaling pathway. + + + + 33875643 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 38 + 0 + + + + + + + 18 + The role of the calmodulin-binding and calmodulin-like domains of the epidermal growth factor receptor in tyrosine kinase activation. + + + + 33305427 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 36 + 0 + + + + + + + 18 + Comprehensive review of targeted therapy for colorectal cancer. + + + + 32296018 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 36 + 0 + + + + + + + 18 + E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. + + + + 33627783 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 35 + 0 + + + + + + + 18 + Structural basis of the effect of activating mutations on the EGF receptor. + + + + 34319231 + + + + + + + + 2021 + 10 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 16 + 11 + 34 + 0 + + + + + + + 18 + FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis Development. + + + + 32888953 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 9 + 11 + 43 + 0 + + + + + + + 18 + Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT. + + + + 32868760 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 9 + 11 + 42 + 0 + + + + + + + 18 + Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer. + + + + 32792513 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + 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pathways. + + + + 34032851 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 9 + 11 + 35 + 0 + + + + + + + 18 + Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/beta-catenin signaling regulation. + + + + 33398673 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 9 + 11 + 33 + 0 + + + + + + + 18 + [Immune Microenvironment Comparation Study between EGFR Mutant and EGFR Wild Type Lung Adenocarcinoma Patients Based on TCGA Database]. + + + + 33910272 + + + + + + + + 2021 + 10 + 9 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 9 + 11 + 32 + 0 + + + + + + + 18 + Diffusion tensor and postcontrast T1-weighted imaging radiomics to differentiate the epidermal growth factor receptor mutation status of brain metastases from non-small cell lung cancer. + + + + 32827069 + + + + + + + + 2021 + 10 + 2 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 2 + 11 + 26 + 0 + + + + + + + 18 + Simultaneous Single Cell Gene Expression and EGFR Mutation Analysis of Circulating Tumor Cells Reveals Distinct Phenotypes in NSCLC. + + + + 32700450 + + + + + + + + 2021 + 10 + 2 + 10 + 3 + 0 + + + + + + + + + 2021 + 10 + 2 + 11 + 26 + 0 + + + + + + + 18 + Somatic Copy-Number Alterations in Plasma Circulating Tumor DNA from Advanced EGFR-Mutated Lung Adenocarcinoma Patients. + + + + 33919291 + + + + + + + + 2021 + 9 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 25 + 11 + 14 + 0 + + + + + + + 18 + Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes. + + + + 33373325 + + + + + + + + 2021 + 9 + 25 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 25 + 11 + 9 + 0 + + + + + + + 18 + Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners. + + + + 33741329 + + + + + + + + 2021 + 9 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 18 + 11 + 13 + 0 + + + + + + + 18 + 20(S)-Ginsenoside Rg3 Inhibits Lung Cancer Cell Proliferation by Targeting EGFR-Mediated Ras/Raf/MEK/ERK Pathway. + + + + 33641655 + + + + + + + + 2021 + 9 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 18 + 11 + 12 + 0 + + + + + + + 18 + Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer. + + + + 34320120 + + + + + + + + 2021 + 9 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 18 + 11 + 12 + 0 + + + + + + + 18 + Novel Perbutyrylated Glucose Derivatives of (-)-Epigallocatechin-3-Gallate Inhibit Cancer Cells Proliferation by Decreasing Phosphorylation of the EGFR: Synthesis, Cytotoxicity, and Molecular Docking. + + + + 34299635 + + + + + + + + 2021 + 9 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 18 + 11 + 11 + 0 + + + + + + + 18 + Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. + + + + 34461927 + + + + + + + + 2021 + 9 + 18 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 18 + 11 + 11 + 0 + 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Exon 20 insertion in advanced non-small cell lung cancer: A systematic literature review. + + + + 33684140 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 34 + 0 + + + + + + + 18 + USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics. + + + + 33202887 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 34 + 0 + + + + + + + 18 + Preparation and identification of an anti-idiotypic antibody antagonist (FG8) for EGFR that shows potential activity against liver cancer cells. + + + + 33141321 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 33 + 0 + + + + + + + 18 + Multiparametric MRI-Based Radiomics Approaches for Preoperative Prediction of EGFR Mutation Status in Spinal Bone Metastases in Patients with Lung Adenocarcinoma. + + + + 33638577 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 32 + 0 + + + + + + + 18 + Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. + + + + 33572344 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 32 + 0 + + + + + + + 18 + FGD5 facilitates tumor growth by regulating EGFR ubiquitination in gastric cancer. + + + + 34034092 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 29 + 0 + + + + + + + 18 + Pediatric Soft Tissue Tumors With BCOR ITD Express EGFR but Not OLIG2. + + + + 32790583 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 28 + 0 + + + + + + + 18 + Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646/EGFR in Human Trabecular Meshwork Cells. + + + + 33335643 + + + + + + + + 2021 + 9 + 11 + 10 + 2 + 0 + + + + + + + + + 2021 + 9 + 11 + 11 + 26 + 0 + + + + + + + 18 + Germline EGFR variants are over-represented in adolescents and young adults (AYA) with adrenocortical carcinoma. + + + + 33326033 + + + + + + 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family, are aberrantly expressed in EGFR mutated lung adenocarcinoma. + + + + 32853956 + + + + + + + + 2021 + 8 + 21 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 21 + 11 + 7 + 0 + + + + + + + 18 + Extensive functional evaluation of exon 20 insertion mutations of EGFR. + + + + 33395611 + + + + + + + + 2021 + 8 + 21 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 21 + 11 + 6 + 0 + + + + + + + 18 + Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors. + + + + 33597720 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 17 + 0 + + + + + + + 18 + CSF cell-free DNA EGFR testing using DdPCR holds promise over conventional modalities for diagnosing leptomeningeal involvement in patients with non-small cell lung cancer. + + + + 32784073 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 16 + 0 + + + + + + + 18 + Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient. + + + + 32777674 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 16 + 0 + + + + + + + 18 + Dysregulated miR-137 and its target EGFR contribute to the progression of pituitary adenomas. + + + + 33246030 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 9 + 0 + + + + + + + 18 + External and internal EGFR-activating signals drive mammary epithelial cells proliferation and viability. + + + + 33181234 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 8 + 0 + + + + + + + 18 + Computational studies of potent covalent inhibitors on wild type or T790M/L858R mutant epidermal growth factor receptor. + + + + 32668314 + + + + + + + + 2021 + 8 + 14 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 14 + 11 + 6 + 0 + + + + + + + 18 + Association of CD8 T cell apoptosis and EGFR mutation in non-small lung cancer patients. + + + + 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32558183 + + + + + + + + 2021 + 8 + 7 + 10 + 2 + 0 + + + + + + + + + 2021 + 8 + 7 + 11 + 18 + 0 + + + + + + + 18 + PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling. + + + + 33570794 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 23 + 0 + + + + + + + 18 + Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. + + + + 33479497 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 22 + 0 + + + + + + + 18 + ANO1 regulates the maintenance of stemness in glioblastoma stem cells by stabilizing EGFRvIII. + + + + 33452454 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 22 + 0 + + + + + + + 18 + Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. + + + + 33420372 + + + + + + + + 2021 + 7 + 31 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0 + + + + + + + 18 + PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III. + + + + 33188296 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 15 + 0 + + + + + + + 18 + PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy. + + + + 31448672 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 13 + 0 + + + + + + + 18 + Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis. + + + + 33664875 + + + + + + + + 2021 + 7 + 31 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 31 + 11 + 12 + 0 + + + + + + + 18 + The 14-3-3sigma protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway. + + + + 33391517 + + + + + + + + 2021 + 7 + 24 + 10 + 2 + 0 + + + + + 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immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation. + + + + 33537094 + + + + + + + + 2021 + 7 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 24 + 11 + 6 + 0 + + + + + + + 18 + Analysis of EGFR, KRAS, and PIK3CA gene mutation rates and clinical distribution in patients with different types of lung cancer. + + + + 34217313 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 14 + 0 + + + + + + + 18 + Performance Characteristics of a Real-Time Polymerase Chain Reaction Assay for the Detection of Epidermal Growth Factor Receptor (EGFR) Mutations in Plasma Samples of Non-Small Cell Lung Cancer (NSCLC) Patients. + + + + 32406048 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 12 + 0 + + + + + + + 18 + Developing an Arrayed CRISPR-Cas9 Co-Culture Screen for Immuno-Oncology Target ID. + + + + 32375580 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 12 + 0 + + + + + + + 18 + PLCgamma1dependent invasion and migration of cells expressing NSCLCassociated EGFR mutants. + + + + 32945365 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 9 + 0 + + + + + + + 18 + Mitogen-activated protein kinase inhibition-induced modulation of epidermal growth factor receptor signaling in human head and neck squamous cell carcinoma. + + + + 33533173 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 6 + 0 + + + + + + + 18 + DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration. + + + + 33420898 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 6 + 0 + + + + + + + 18 + Detection of Low-level EGFR c.2369 C > T (p.Thr790Met) Resistance Mutation in Pre-treatment Non-small Cell Lung Carcinomas Harboring Activating EGFR Mutations and Correlation with Clinical Outcomes. + + + + 32506395 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 3 + 0 + + + + + + + 18 + The papillomavirus E5 gene does not affect EGFR transcription and overall survival in cervical cancer. + + + + 31696949 + + + + + + + + 2021 + 7 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 17 + 11 + 3 + 0 + + + + + + + 18 + EGFR mutation detection of lung circulating tumor cells using a multifunctional microfluidic chip. + + + + 33592778 + + + + + + + + 2021 + 7 + 10 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 10 + 11 + 17 + 0 + + + + + + + 18 + Dissecting the molecular recognition of dual lapatinib derivatives for EGFR/HER2. + + + + 31828486 + + + + + + + + 2021 + 7 + 10 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 10 + 11 + 12 + 0 + + + + + + + 18 + PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas. + + + + 32727536 + + + + + + + + 2021 + 7 + 10 + 10 + 2 + 0 + + + + + + + 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is associated with milk epidermal growth factor in Filipino women. + + + + 32057154 + + + + + + + + 2021 + 7 + 3 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 3 + 11 + 13 + 0 + + + + + + + 18 + Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. + + + + 32323422 + + + + + + + + 2021 + 7 + 3 + 10 + 2 + 0 + + + + + + + + + 2021 + 7 + 3 + 11 + 9 + 0 + + + + + + + 18 + Evaluation of Nestin and EGFR in Patients with Glioblastoma Multiforme in a Public Hospital in Iran. + + + + 33112545 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 11 + 0 + + + + + + + 18 + Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway. + + + + 33096942 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 11 + 0 + + + + + + + 18 + Genetic variants of the EGFR ligand-binding domain and their association with structural alterations in Arab cancer patients. + + + + 33874989 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 9 + 0 + + + + + + + 18 + Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling. + + + + 33795873 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 9 + 0 + + + + + + + 18 + Histological transformation of lung adenocarcinoma to small cell lung cancer with mutant C797S conferring acquired resistance to osimertinib. + + + + 32600081 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 7 + 0 + + + + + + + 18 + High expression of NEK2 promotes lung cancer progression and drug resistance and is regulated by mutant EGFR. + + + + 32761510 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 3 + 0 + + + + + + + 18 + Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines. + + + + 33287368 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 2 + 0 + + + + + + + 18 + Positive EGFR mutation status is a risk of recurrence in pN0-1 lung adenocarcinoma when combined with pathological stage and histological subtype: A retrospective multi-center analysis. + + + + 32035371 + + + + + + + + 2021 + 6 + 26 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 26 + 11 + 1 + 0 + + + + + + + 18 + Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes. + + + + 32690371 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 37 + 0 + + + + + + + 18 + The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris. + + + + 32421896 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + 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18 + Silibinin induces metabolic crisis in triple-negative breast cancer cells by modulating EGFR-MYC-TXNIP axis: potential therapeutic implications. + + + + 32356386 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 35 + 0 + + + + + + + 18 + Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis. + + + + 33172155 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 33 + 0 + + + + + + + 18 + Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis. + + + + 34045585 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 33 + 0 + + + + + + + 18 + Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide. + + + + 33138194 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 31 + 0 + + + + + + + 18 + Combined High Resistin and EGFR Expression Predicts a Poor Prognosis in Breast Cancer. + + + + 33313320 + + + + + + + + 2021 + 6 + 19 + 10 + 2 + 0 + + + + + + + + + 2021 + 6 + 19 + 11 + 29 + 0 + + + + + + + 18 + Detailed identification of epidermal growth factor receptor mutations in lung adenocarcinoma: Combining radiomics with machine learning. + + + + 32416013 + + + + + + + + 2021 + 6 + 12 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 12 + 13 + 0 + 0 + + + + + + + 18 + Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization. + + + + 31668800 + + + + + + + + 2021 + 6 + 12 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 12 + 12 + 59 + 0 + + + + + + + 18 + [EGFR protein is a negative prognostic and predictive factor in wild-type RAS colorectal cancer].", trans "Az EGFR-protein-expresszio negativ prognosztikus es prediktiv marker vad RAS tipusu vastagbelrakban. + + + 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32917240 + + + + + + + + 2021 + 6 + 12 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 12 + 12 + 54 + 0 + + + + + + + 18 + Comparison of Biocartis IDYLLA cartridge assay with Qiagen GeneReader NGS for detection of targetable mutations in EGFR, KRAS/NRAS, and BRAF genes. + + + + 33773991 + + + + + + + + 2021 + 6 + 12 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 12 + 12 + 52 + 0 + + + + + + + 18 + Monitoring epidermal growth factor receptor C797S mutation in Japanese non-small cell lung cancer patients with serial cell-free DNA evaluation using digital droplet PCR. + + + + 33686722 + + + + + + + + 2021 + 6 + 12 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 12 + 12 + 52 + 0 + + + + + + + 18 + Oncogenic mutations within the beta3-alphaC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies. + + + + 32757330 + + + + + + + + 2021 + 6 + 5 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 5 + 13 + 9 + 0 + + + + + + + 18 + Treatment outcome and pattern of recurrence of sinonasal squamous cell carcinoma with EGFR-mutation and human papillomavirus. + + + + 33676817 + + + + + + + + 2021 + 6 + 5 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 5 + 13 + 7 + 0 + + + + + + + 18 + Evaluation of the potential effect of dacomitinib, an EGFR tyrosine kinase inhibitor, on ECG parameters in patients with advanced non-small cell lung cancer. + + + + 31858327 + + + + + + + + 2021 + 6 + 5 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 5 + 13 + 6 + 0 + + + + + + + 18 + Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC. + + + + 32234966 + + + + + + + + 2021 + 6 + 5 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 5 + 13 + 4 + 0 + + + + + + + 18 + Impact of neutrophil-to-lymphocyte ratio in patients with EGFR-mutant NSCLC treated with tyrosine kinase inhibitors. + + + + 32157598 + + + + + + + + 2021 + 6 + 5 + 10 + 3 + 0 + + + + + + + + + 2021 + 6 + 5 + 13 + 3 + 0 + + + + + + + 18 + Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity. + 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Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy. + + + + 32142290 + + + + + + + + 2021 + 5 + 29 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 29 + 12 + 58 + 0 + + + + + + + 18 + Evaluation of plasma EGFR mutation as an early predictor of response of erlotinib plus bevacizumab treatment in the NEJ026 study. + + + + 32629391 + + + + + + + + 2021 + 5 + 29 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 29 + 12 + 57 + 0 + + + + + + + 18 + Rational Application of First-Line EGFR-TKIs Combined with Antiangiogenic Inhibitors in Advanced EGFR-Mutant Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. + + + + 33575349 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 51 + 0 + + + + + + + 18 + PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer. + + + + 33271263 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 49 + 0 + + + + + + + 18 + Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. + + + + 31994813 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 48 + 0 + + + + + + + 18 + Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. + + + + 31985874 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 48 + 0 + + + + + + + 18 + EGFR and BRAF mutations in inverted sinonasal papilloma - a more complex landscape? + + + + 33048186 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 46 + 0 + + + + + + + 18 + Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-kB)-Dependent Pathway. + + + + 32881844 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 46 + 0 + + + + + + + 18 + Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma. + + + + 32056244 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 45 + 0 + + + + + + + 18 + MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of epidermal growth factor receptor-mutant lung cancers. + + + + 32497272 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 42 + 0 + + + + + + + 18 + Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. + + + + 31758670 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 42 + 0 + + + + + + + 18 + NRF2 Enables EGFR Signaling in Melanoma Cells. + + + + 33916908 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 41 + 0 + + + + + + + 18 + CT radiomics-based prediction of anaplastic lymphoma kinase and epidermal growth factor receptor mutations in lung adenocarcinoma. + + + + 33862316 + + + + + + + + 2021 + 5 + 22 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 22 + 12 + 41 + 0 + + + + + + + 18 + Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone. + + + + 33952497 + + + + + + + + 2021 + 5 + 15 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 15 + 13 + 32 + 0 + + + + + + + 18 + Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini. + + + + 33921304 + + + + + + + + 2021 + 5 + 15 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 15 + 13 + 32 + 0 + + + + + + + 18 + Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity. + + + + 33805918 + + + + + + + + 2021 + 5 + 15 + 10 + 3 + 0 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+ + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 24 + 0 + + + + + + + 18 + Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling. + + + + 33361428 + + + + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 21 + 0 + + + + + + + 18 + Mechanism of RET gene mediated EGFR signaling pathway on epithelial-mesenchymal transition, proliferation and apoptosis of papillary thyroid carcinoma cells. + + + + 32767330 + + + + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 18 + 0 + + + + + + + 18 + A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR. + + + + 33130881 + + + + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 16 + 0 + + + + + + + 18 + Compared to plasma, bronchial washing fluid shows higher diagnostic yields for detecting EGFR-TKI sensitizing mutations by ddPCR in lung cancer. + + + + 32517757 + + + + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 13 + 0 + + + + + + + 18 + Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors. + + + + 31679083 + + + + + + + + 2021 + 5 + 8 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 8 + 14 + 8 + 0 + + + + + + + 18 + Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications. + + + + 33886813 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 9 + 0 + + + + + + + 18 + [Semiquantitative parameters of (18)F-FDG PET/CT, gene mutation states of epidermal growth factor receptor and anaplastic lymphoma kinase in prognosis evaluation of patients with lung adenocarcinoma]. + + + + 33879893 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 9 + 0 + + + + + + + 18 + The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma. + + + + 33799753 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 9 + 0 + + + + + + + 18 + FAT10 promotes the progression of bladder cancer by upregulating HK2 through the EGFR/AKT pathway. + + + + 33253711 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 7 + 0 + + + + + + + 18 + MALT1 is a potential therapeutic target in glioblastoma and plays a crucial role in EGFR-induced NF-kappaB activation. + + + + 32452133 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 4 + 0 + + + + + + + 18 + EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2. + + + + 31823521 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 3 + 0 + + + + + + + 18 + LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival. + + + + 33152401 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 2 + 0 + + + + + + + 18 + EGFR overexpression increases radiotherapy response in HPV-positive head and neck cancer through inhibition of DNA damage repair and HPV E6 downregulation. + + + + 33137407 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 2 + 0 + + + + + + + 18 + Association between epidermal growth factor receptor gene polymorphisms and susceptibility to Parkinson's disease. + + + + 32712352 + + + + + + + + 2021 + 5 + 1 + 10 + 3 + 0 + + + + + + + + + 2021 + 5 + 1 + 13 + 1 + 0 + + + + + + + 18 + Cost-effectiveness analysis comparing companion diagnostic tests for EGFR, ALK, and ROS1 versus next-generation sequencing (NGS) in advanced adenocarcinoma lung cancer patients. + + + + 32928143 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 18 + 0 + + + + + + + 18 + EGFR and PDL1: A Match (Not) Made in Heaven-A Real-World Retrospective Analysis of PDL1 Expression in EGFR-Mutated NSCLC. + + + + 33641057 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 15 + 0 + + + + + + + 18 + Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches. + + + + 31812932 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 12 + 0 + + + + + + + 18 + Robust radiogenomics approach to the identification of EGFR mutations among patients with NSCLC from three different countries using topologically invariant Betti numbers. + + + + 33428651 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 12 + 0 + + + + + + + 18 + Altered Regulation of HIF-1alpha in Naive- and Drug-Resistant EGFR-Mutant NSCLC: Implications for a Vascular Endothelial Growth Factor-Dependent Phenotype. + + + + 33309987 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 11 + 0 + + + + + + + 18 + Differences in failure patterns according to the EGFR mutation status after proton beam therapy for early stage non-small cell lung cancer. + + + + 32387485 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 9 + 0 + + + + + + + 18 + Exosomes transmit T790M mutation-induced resistance in EGFR-mutant NSCLC by activating PI3K/AKT signalling pathway. + + + + 31894895 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 9 + 0 + + + + + + + 18 + EGFR-independent EGFR-mutant lung adenocarcinoma cells depend on Bcl-xL and MCL1 for survival. + + + + 32223928 + + + + + + + + 2021 + 4 + 24 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 24 + 13 + 6 + 0 + + + + + + + 18 + EGFR-mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions. + + + + 32926474 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 17 + 0 + + + + + + + 18 + Prognostic analysis of patients with non-small cell lung cancer harboring exon 19 or 21 mutation in the epidermal growth factor gene and brain metastases. + + + + 32883221 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 17 + 0 + + + + + + + 18 + ciRS-7 Promotes the Proliferation and Migration of Papillary Thyroid Cancer by Negatively Regulating the miR-7/Epidermal Growth Factor Receptor Axis. + + + + 32685551 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 16 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor and its Oncogenic EGFRvIII Variant in Benign and Malignant Brain Tumors. + + + + 33517305 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 15 + 0 + + + + + + + 18 + Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells. + + + + 33310188 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 14 + 0 + + + + + + + 18 + The next tier of EGFR resistance mutations in lung cancer. + + + + 33060857 + + + + + + + + 2021 + 4 + 17 + 10 + 2 + 0 + + + + + + + + + 2021 + 4 + 17 + 13 + 12 + 0 + + + + + + + 18 + Genetic Polymorphism of Epidermal Growth Factor Gene as a Predictor of Hepatocellular Carcinoma in Hepatitis C Cirrhotic Patients. + + + + 32711431 + + + + + + + + 2021 + 4 + 10 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 13 + 10 + 15 + 0 + + + + + + + 18 + Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers. + + + + 33741979 + + + + + + + + 2021 + 4 + 10 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 13 + 10 + 14 + 0 + + + + + + + 18 + Multiclonality and Radiosensitivity of Granulocyte-colony Stimulating Factor-Producing Lung Adenocarcinoma Positive for an Activating EGFR Mutation. + + + + 31649000 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 37 + 0 + + + + + + + 18 + Phase II Study Evaluating the Mechanisms of Resistance on Tumor Tissue and Liquid Biopsy in Patients With EGFR-mutated Non-pretreated Advanced Lung Cancer Receiving Osimertinib Until and Beyond Radiologic Progression: The MELROSE Trial. + + + + 31648999 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 37 + 0 + + + + + + + 18 + Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-grade gliomas. + + + + 32785770 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 37 + 0 + + + + + + + 18 + 6-Color Crystal Digital PCR(TM) for the High-Plex Detection of EGFR Mutations in Non-Small Cell Lung Cancer. + + + + 33683690 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + 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A Role of Prolidase. + + + + 33477820 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 36 + 0 + + + + + + + 18 + CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma. + + + + 32507856 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 35 + 0 + + + + + + + 18 + Updated Insights on EGFR Signaling Pathways in Glioma. + + + + 33435537 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 34 + 0 + + + + + + + 18 + The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells. + + + + 33396457 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 34 + 0 + + + + + + + 18 + Rose (Rosa gallica) Petal Extract Suppress Proliferation, Migration, and Invasion of Human Lung Adenocarcinoma A549 Cells through via the EGFR Signaling Pathway. + + + + 33158043 + 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Prevalence of EGFR Mutations in Lung Adenocarcinomas From Brazilian Patients Harboring the TP53 p.R337H Variant. + + + + 31889631 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 31 + 0 + + + + + + + 18 + Clinical Features and Progression Pattern of Acquired T790M-positive Compared With T790M-negative EGFR Mutant Non-small-cell Lung Cancer: Catching Tumor and Clinical Heterogeneity Over Time Through Liquid Biopsy. + + + + 31601525 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 31 + 0 + + + + + + + 18 + Critical Assessment in Routine Clinical Practice of Liquid Biopsy for EGFR Status Testing in Non-Small-Cell Lung Cancer: A Single-Laboratory Experience (LPCE, Nice, France). + + + + 31519454 + + + + + + + + 2021 + 4 + 3 + 10 + 3 + 0 + + + + + + + + + 2021 + 4 + 3 + 13 + 30 + 0 + + + + + + + 18 + Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. + + + + 33139779 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+ + + + + + + 2021 + 3 + 27 + 14 + 41 + 0 + + + + + + + 18 + Absence of EGFR C797S Mutation in Tyrosine Kinase Inhibitor-Naive Non-Small Cell Lung Cancer Tissues. + + + + 31243697 + + + + + + + + 2021 + 3 + 27 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 27 + 14 + 41 + 0 + + + + + + + 18 + What is the prognostic value of reduced eGFR? + + + + 33713086 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 36 + 0 + + + + + + + 18 + [Clinicopathological significance in non-small cell lung cancer with mutations and co-mutations of EGFR, ALK and ROS1]. + + + + 33677892 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 35 + 0 + + + + + + + 18 + Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras. + + + + 32972751 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 32 + 0 + + + + + + + 18 + Low-Dose Nicotine Activates EGFR Signaling via alpha5-nAChR and Promotes Lung Adenocarcinoma Progression. + + + + 32957649 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 32 + 0 + + + + + + + 18 + Gremlin-1 augments the oestrogen-related receptor alpha signalling through EGFR activation: implications for the progression of breast cancer. + + + + 32572171 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 31 + 0 + + + + + + + 18 + NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment. + + + + 32901097 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 29 + 0 + + + + + + + 18 + EGFR/Ras-induced CCL20 production modulates the tumour microenvironment. + + + + 32601464 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + + + + + + + 2021 + 3 + 20 + 13 + 28 + 0 + + + + + + + 18 + NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma. + + + + 32382041 + + + + + + + + 2021 + 3 + 20 + 10 + 3 + 0 + + + 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non-small cell lung cancer. + + + + 32211850 + + + + + + + + 2021 + 2 + 13 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 13 + 13 + 29 + 0 + + + + + + + 18 + Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma. + + + + 32747363 + + + + + + + + 2021 + 2 + 13 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 13 + 13 + 28 + 0 + + + + + + + 18 + HBx increases EGFR expression by inhibiting miR129-5p function. + + + + 32703411 + + + + + + + + 2021 + 2 + 13 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 13 + 13 + 28 + 0 + + + + + + + 18 + The epidermal growth factor receptor variant type III mutation frequently found in gliomas induces astrogenesis in human cerebral organoids. + + + + 33283409 + + + + + + + + 2021 + 2 + 13 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 13 + 13 + 27 + 0 + + + + + + + 18 + The clinical value of the combined detection of sEGFR, CA125 and HE4 for epithelial ovarian cancer diagnosis. + + + + 32016961 + + + + + + + + 2021 + 2 + 13 + 10 + 3 + 0 + + + + + + + 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Identification of a novel anti-EGFR nanobody by phage display and its distinct paratope and epitope via homology modeling and molecular docking. + + + + 33130376 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 28 + 0 + + + + + + + 18 + Clinicopathologic Significance of EGFR Mutation and HPV Infection in Sinonasal Squamous Cell Carcinoma. + + + + 32868526 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 27 + 0 + + + + + + + 18 + EGFR forms ligand-independent oligomers that are distinct from the active state. + + + + 32727847 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 27 + 0 + + + + + + + 18 + Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance. + + + + 32669362 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 26 + 0 + + + + + + + 18 + Characteristics of patients with EGFR-mutant non-small-cell lung cancer who benefited from immune checkpoint inhibitors. + + + + 32648165 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 26 + 0 + + + + + + + 18 + Inter-lobe Motions Allosterically Regulate the Structure and Function of EGFR Kinase. + + + + 32534062 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 26 + 0 + + + + + + + 18 + Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification. + + + + 31776131 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 2 + 2 + 13 + 25 + 0 + + + + + + + 18 + Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation-Positive Non-Small Cell Lung Cancer. + + + + 31937613 + + + + + + + + 2021 + 1 + 30 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 30 + 13 + 3 + 0 + + + + + + + 18 + Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity. + + + + 31911540 + + + + + 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nonsmallcell lung cancer cells. + + + + 32236608 + + + + + + + + 2021 + 1 + 23 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 23 + 12 + 57 + 0 + + + + + + + 18 + Real-world efficacy and potential mechanism of resistance of icotinib in Asian advanced non-small cell lung cancer with EGFR uncommon mutations: A multi-center study. + + + + 31692291 + + + + + + + + 2021 + 1 + 23 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 23 + 12 + 56 + 0 + + + + + + + 18 + EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma. + + + + 31852834 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 16 + 15 + 57 + 0 + + + + + + + 18 + Concomitant echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in non-small cell lung cancer patients from eastern India. + + + + 32930129 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 16 + 15 + 56 + 0 + + + + + + + 18 + Association of cytokines levels with epidermal growth factor receptor mutation in lung cancer patients. + + + + 32930123 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 16 + 15 + 56 + 0 + + + + + + + 18 + Primary Tumor Resection Is Associated with a Better Outcome among Advanced EGFR-Mutant Lung Adenocarcinoma Patients Receiving EGFR-TKI Treatment. + + + + 32894845 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 16 + 15 + 56 + 0 + + + + + + + 18 + MiR-450a-5p strengthens the drug sensitivity of gefitinib in glioma chemotherapy via regulating autophagy by targeting EGFR. + + + + 32820249 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + + + 2021 + 1 + 16 + 15 + 55 + 0 + + + + + + + 18 + Mutations in the exons of epidermal growth factor receptor gene are associated with clinicopathological features of lung cancer. + + + + 32747142 + + + + + + + + 2021 + 1 + 16 + 10 + 3 + 0 + + + + + + + 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sinonasal inverted papilloma and squamous cell carcinoma. + + + + 32199023 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 13 + 3 + 0 + + + + + + + 18 + First-line angiogenesis inhibitor plus erlotinib versus erlotinib alone for advanced non-small-cell lung cancer harboring an EGFR mutation. + + + + 32632581 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 13 + 0 + 0 + + + + + + + 18 + Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas. + + + + 32587323 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 13 + 0 + 0 + + + + + + + 18 + Oxidative stress-mediated epidermal growth factor receptor activation regulates PM2.5-induced over-secretion of pro-inflammatory mediators from human bronchial epithelial cells. + + + + 32562736 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 13 + 0 + 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expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation. + + + + 32170146 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 12 + 58 + 0 + + + + + + + 18 + Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer. + + + + 32157215 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 12 + 58 + 0 + + + + + + + 18 + Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway. + + + + 32058048 + + + + + + + + 2020 + 12 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 12 + 5 + 12 + 57 + 0 + + + + + + + 18 + VHL-HIF-2alpha axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR. + + + + 32291411 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 17 + 0 + + + + + + + 18 + Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells. + + + + 32242147 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 17 + 0 + + + + + + + 18 + Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation. + + + + 32235891 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 17 + 0 + + + + + + + 18 + Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma. + + + + 33053439 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 16 + 0 + + + + + + + 18 + Functional coding/non-coding variants in EGFR, ROS1 and ALK genes and their role in liquid biopsy as a personalized therapy. + + + + 33038629 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 16 + 0 + + + + + + + 18 + HUNK phosphorylates EGFR to regulate breast cancer metastasis. + + + + 31597954 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 15 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor Gene Mutation Status in Primary Lung Adenocarcinoma and Corresponding Bone Metastases. + + + + 30601156 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 15 + 0 + + + + + + + 18 + Comparison detection methods for EGFR in formalin-fixed paraffin-embedded tissues of patients with NSCLC. + + + + 31859115 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 14 + 0 + + + + + + + 18 + Intense Expression of EGFR L858R Characterizes the Micropapillary Component and L858R Is Associated with the Risk of Recurrence in pN0M0 Lung Adenocarcinoma with the Micropapillary Component. + + + + 31732945 + + + + + + + + 2020 + 11 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 28 + 13 + 12 + 0 + + + + + + + 18 + Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. + + + + 32080212 + + + + + + + + 2020 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 32 + 0 + + + + + + + 18 + Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity. + + + + 32040702 + + + + + + + + 2020 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 31 + 0 + + + + + + + 18 + Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation. + + + + 32093124 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 28 + 0 + + + + + + + 18 + Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese population. + + + + 32066856 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 27 + 0 + + + + + + + 18 + EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma. + + + + 32034306 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 26 + 0 + + + + + + + 18 + Correlation of epidermal growth factor receptor mutation status in plasma and tissue samples of patients with non-small cell lung cancer. + + + + 32930128 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 22 + 0 + + + + + + + 18 + Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway. + + + + 31789102 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 21 + 0 + + + + + + + 18 + The effects of somatic mutations on EGFR interaction with anti-EGFR monoclonal antibodies: Implication for acquired resistance. + + + + 31228284 + + + + + + + + 2020 + 11 + 21 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 20 + 0 + + + + + + + 18 + Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies. + + + + 32207968 + + + + + + + + 2020 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 14 + 0 + + + + + + + 18 + Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos. + + + + 31819141 + + + + + + + + 2020 + 11 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 13 + 0 + + + + + + + 18 + IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. + + + + 31805013 + + + + + + + + 2020 + 11 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 11 + 21 + 13 + 13 + 0 + + + + + + + 18 + EGFR in enterocytes & endothelium and HIF1alpha in enterocytes are dispensable for massive small bowel resection induced angiogenesis. + + + + 32931498 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 20 + 0 + + + + + + + 18 + ErbB1 and ErbB2 overexpression in patients with sinonasal inverted papilloma and inverted papilloma with squamous cell carcinoma in China. + + + + 31556771 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 18 + 0 + + + + + + + 18 + Analyzing expression and phosphorylation of the EGF receptor in HNSCC. + + + + 31537844 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 18 + 0 + + + + + + + 18 + Comparative expression of immunohistochemical biomarkers in cribriform and pattern 4 non-cribriform prostatic adenocarcinoma. + + + + 32061580 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 15 + 0 + + + + + + + 18 + Urothelial cancer harbours EGFR and HER2 amplifications and exon 20 insertions. + + + + 31985116 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 15 + 0 + + + + + + + 18 + Sensitive detection of low-abundance in-frame deletions in EGFR exon 19 using novel wild-type blockers in real-time PCR. + + + + 31164704 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 14 + 0 + + + + + + + 18 + EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients. + + + + 31092882 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 14 + 0 + + + + + + + 18 + Impact of HPV E5 on viral life cycle via EGFR signaling. + + + + 31836496 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 13 + 0 + + + + + + + 18 + Cell proliferation and invasion are regulated differently by EGFR and MRP1 in T-DM1-resistant breast cancer cells. + + + + 31704984 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 13 + 0 + + + + + + + 18 + EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2. + + + + 31665243 + + + + + + + + 2020 + 10 + 31 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 31 + 13 + 12 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor and Abl2 Kinase Regulate Distinct Steps of Human Papillomavirus 16 Endocytosis. + + + + 32188731 + + + + + + + + 2020 + 10 + 24 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 24 + 14 + 8 + 0 + + + + + + + 18 + EGFR Gene Mutation and Methodological Evaluation in 399 Patients with Non-small Cell Lung Cancer. + + + + 32166668 + + + + + + + + 2020 + 10 + 24 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 24 + 14 + 8 + 0 + + + + + + + 18 + BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation. + + + + 31588230 + + + + + + + + 2020 + 10 + 24 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 24 + 13 + 58 + 0 + + + + + + + 18 + Treatment of Patients With Non-small-cell Lung Cancer With Uncommon EGFR Mutations in Clinical Practice. + + + + 32988903 + + + + + + + + 2020 + 10 + 10 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 10 + 13 + 4 + 0 + + + + + + + 18 + Prognostic value of TP53 co-mutation status combined with EGFR mutation in patients with lung adenocarcinoma. + + + + 32743759 + + + + + + + + 2020 + 10 + 10 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 10 + 13 + 3 + 0 + + + + + + + 18 + MicroRNA-141-3p affected proliferation, chemosensitivity, migration and invasion of colorectal cancer cells by targeting EGFR. + + + + 31704502 + + + + + + + + 2020 + 10 + 10 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 10 + 12 + 59 + 0 + + + + + + + 18 + A novel loopmediated isothermal amplification method for efficient and robust detection of EGFR mutations. + + + + 32124949 + + + + + + + + 2020 + 10 + 10 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 10 + 12 + 58 + 0 + + + + + + + 18 + Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning. + + + + 30635290 + + + + + + + + 2020 + 10 + 10 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 10 + 12 + 58 + 0 + + + + + + + 18 + HCMV-induced signaling through gB-EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes. + + + + 32723814 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 59 + 0 + + + + + + + 18 + Emerging RAS, BRAF, and EGFR mutations in cell-free DNA of metastatic colorectal patients are associated with both primary and secondary resistance to first-line anti-EGFR therapy. + + + + 32394048 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 58 + 0 + + + + + + + 18 + Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370. + + + + 31298332 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 57 + 0 + + + + + + + 18 + Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations. + + + + 32005111 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 57 + 0 + + + + + + + 18 + Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression. + + + + 32093629 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 53 + 0 + + + + + + + 18 + Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment. + + + + 31780432 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 53 + 0 + + + + + + + 18 + Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. + + + + 30914776 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 51 + 0 + + + + + + + 18 + A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy. + + + + 30907457 + + + + + + + + 2020 + 10 + 3 + 10 + 3 + 0 + + + + + + + + + 2020 + 10 + 3 + 12 + 51 + 0 + + + + + + + 18 + MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation. + + + + 31771093 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 13 + 8 + 0 + + + + + + + 18 + Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer. + + + + 30890751 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 13 + 7 + 0 + + + + + + + 18 + Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells. + + + + 31638339 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 13 + 4 + 0 + + + + + + + 18 + The Correlation between EGFR and Androgen Receptor Pathways: A Novel Potential Prognostic Marker in Gastric Cancer. + + + + 31566139 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 13 + 2 + 0 + + + + + + + 18 + Revealing membrane alteration in cellsoverexpressing CA IX and EGFR by Surface-Enhanced Raman Scattering. + + + + 30755643 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 13 + 1 + 0 + + + + + + + 18 + Presence of both EGFR (del19) and ultra-low EGFR (T790M) mutations in non-small cell lung cancer predict favorable clinical outcome for patients treated with tyrosine kinase inhibitors. + + + + 30936123 + + + + + + + + 2020 + 9 + 26 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 26 + 12 + 37 + 0 + + + + + + + 18 + Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. + + + + 31281520 + + + + + + + + 2020 + 9 + 19 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 19 + 16 + 31 + 0 + + + + + + + 18 + Identification of the minimal N-glycosylation on integrin alpha5beta1 required for its inhibitory effect on EGFR signaling and cell proliferation. + + + + 31858971 + + + + + + + + 2020 + 9 + 19 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 19 + 16 + 30 + 0 + + + + + + + 18 + Reversal of EGFR inhibitors' resistance by co-delivering EGFR and integrin alphavbeta3 inhibitors with nanoparticles in non-small cell lung cancer. + + + + 31316001 + + + + + + + + 2020 + 9 + 19 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 19 + 16 + 23 + 0 + + + + + + + 18 + LXRalpha-mediated downregulation of EGFR suppress colorectal cancer cell proliferation. + + + + 31104333 + + + + + + + + 2020 + 9 + 19 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 19 + 16 + 23 + 0 + + + + + + + 18 + Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations. + + + + 30824880 + + + + + + + + 2020 + 9 + 19 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 19 + 16 + 22 + 0 + + + + + + + 18 + Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09). + + + + 31825714 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 16 + 4 + 0 + + + + + + + 18 + TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target. + + + + 32694521 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 16 + 3 + 0 + + + + + + + 18 + Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. + + + + 31507089 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 16 + 1 + 0 + + + + + + + 18 + DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291. + + + + 31454149 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 16 + 1 + 0 + + + + + + + 18 + The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma. + + + + 31182434 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 16 + 0 + 0 + + + + + + + 18 + lncRNA MEG3 modified epithelial-mesenchymal transition of ovarian cancer cells by sponging miR-219a-5p and regulating EGFR. + + + + 31161607 + + + + + + + + 2020 + 9 + 12 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 12 + 15 + 58 + 0 + + + + + + + 18 + The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network. + + + + 31836663 + + + + + + + + 2020 + 9 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 5 + 13 + 55 + 0 + + + + + + + 18 + A Cross-Linking-Aided Immunoprecipitation/Mass Spectrometry Workflow Reveals Extensive Intracellular Trafficking in Time-Resolved, Signal-Dependent Epidermal Growth Factor Receptor Proteome. + + + + 31442056 + + + + + + + + 2020 + 9 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 5 + 13 + 55 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR), KRAS, and BRAF mutations in lung adenocarcinomas: A study from India. + + + + 30591192 + + + + + + + + 2020 + 9 + 5 + 10 + 3 + 0 + + + + + + + + + 2020 + 9 + 5 + 13 + 54 + 0 + + + + + + + 18 + Fusion affecting EGFR gene was detected in unselected lung adenocarcinomas in oncogenic driver-negative lung adenocarcinomas from Chinese population. + + + + 31382039 + + + + + + + + 2020 + 8 + 29 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 29 + 12 + 20 + 0 + + + + + + + 18 + In non small lung cancer somatic mutation of EGFR can acquire resistance to osimertinib through development of the EGFR C797S mutation. In this scenario, the tumor may respond transiently to reversible first-generation EGFR inhibitors (gefitinib or erlotinib), but EGFR C797S can further evolve along with EGFR T790M mutation inducing resistance to gefitinib or erlotinib. + + + + 31377341 + + + + + + + + 2020 + 8 + 29 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 29 + 12 + 14 + 0 + + + + + + + 18 + Acquisition of EGFR M766Q exon 20 mutation is a novel mechanism of acquired resistance to osimertinib in lung adenocarcinoma. + + + + 31254668 + + + + + + + + 2020 + 8 + 29 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 29 + 10 + 17 + 0 + + + + + + + 18 + PTRF/CAVIN1, regulated by SHC1 through the EGFR pathway, is found in urine exosomes as a potential biomarker of ccRCC. + + + + 31605605 + + + + + + + + 2020 + 8 + 22 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 22 + 15 + 31 + 0 + + + + + + + 18 + Preclinical Modeling of Osimertinib for NSCLC With EGFR Exon 20 Insertion Mutations. + + + + 31108249 + + + + + + + + 2020 + 8 + 22 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 22 + 15 + 29 + 0 + + + + + + + 18 + PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinoma. + + + + 31735331 + + + + + + + + 2020 + 8 + 22 + 10 + 3 + 0 + + + + + + + + + 2020 + 8 + 22 + 15 + 27 + 0 + + + + + + + 18 + PIK3CA mutations and specific treatment: do not forget lessons from RAS mutations and EGFR targeting. + + + + 31970497 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 7 + 0 + + + + + + + 18 + Interaction and molecular dynamics simulation study of Osimertinib (AstraZeneca 9291) anticancer drug with the EGFR kinase domain in native protein and mutated L844V and C797S. + + + + 30916819 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 7 + 0 + + + + + + + 18 + Raloxifene nano-micelles effect on triple-negative breast cancer is mediated through estrogen receptor-beta and epidermal growth factor receptor. + + + + 30615483 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 5 + 0 + + + + + + + 18 + Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib. + + + + 31838083 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 5 + 0 + + + + + + + 18 + ALDOLASE A regulates invasion of bladder cancer cells via E-cadherin-EGFR signaling. + + + + 31081974 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 5 + 0 + + + + + + + 18 + Incorporation of EGFR mutation status into M descriptor of new TNM classification influences survival curves in non-small cell lung cancer patients. + + + + 31747381 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 4 + 0 + + + + + + + 18 + Effect of Isomerization of TX-2036 Derivatives on the Interaction With Tyrosine Kinase Domain of EGF Receptor. + + + + 32727791 + + + + + + + + 2020 + 8 + 15 + 13 + 37 + 0 + + + + + + + + + 2020 + 8 + 15 + 19 + 3 + 0 + + + + + + + 18 + Mutation Profile of Resected EGFR-Mutated Lung Adenocarcinoma by Next-Generation Sequencing. + + + + 30872465 + + + + + + + + 2020 + 8 + 12 + 10 + 38 + 0 + + + + + + + + + 2020 + 8 + 13 + 18 + 51 + 0 + + + + + + + 18 + Findings identify a novel glucose/HB-EGF/EGFR axis implicated in beta-cell compensation to increased metabolic demand. + + + + 31882563 + + + + + + + + 2020 + 8 + 12 + 10 + 38 + 0 + + + + + + + + + 2020 + 8 + 12 + 15 + 29 + 0 + + + + + + + 18 + Low-risk human papillomavirus positivity is mutually exclusive with EGFR mutations in sinonasal inverted papilloma, which suggests alternate mechanisms of pathogenesis. + + + + 31743131 + + + + + + + + 2020 + 8 + 12 + 10 + 38 + 0 + + + + + + + + + 2020 + 8 + 12 + 12 + 23 + 0 + + + + + + + 18 + EGFR copy number gain (CNG), detected in 30.5% of the sinonasal squamous cell carcinomas (SNSCCs), was correlated with EGFR protein overexpression (P=0.0001). HPV infection and EGFR CNG were mutually exclusive. The HPV/EGFR CNG group had significantly better overall survival than the HPV/EGFR CNG and HPV/EGFR CNG groups (P=0.0471 and 0.0343, respectively). + + + + 31743130 + + + + + + + + 2020 + 8 + 12 + 10 + 38 + 0 + + + + + + + + + 2020 + 8 + 12 + 12 + 23 + 0 + + + + + + + 18 + The study unravels the interplay between integrin-alpha2beta1/-alpha5beta1 and EGFR in anoikis resistance and suggest that the resistant cells are cancer initiating or cancer stem cells, which may serve as a promising target to combat metastasis of cancer. + + + + 31641961 + + + + + + + + 2020 + 8 + 12 + 10 + 38 + 0 + + + + + + + + + 2020 + 8 + 12 + 11 + 34 + 0 + + + + + + + 18 + Up-regulation of EGFR is associated with gastric cancer cell migration. + + + + 31034158 + + + + + + + + 2020 + 8 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 8 + 1 + 15 + 34 + 0 + + + + + + + 18 + The authors identify critical constituent enhancers present in the first intron of the EGFR gene, and provide a rationale for therapeutic targeting of EGFR intron 1 enhancers through perturbation of AP-1 and BET in EGFR-positive malignancies. + + + + 31444232 + + + + + + + + 2020 + 8 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 8 + 1 + 14 + 59 + 0 + + + + + + + 18 + EGFR mutations were found more frequently in females (63.11%), never-smokers (59.69%), and those with lung adenocarcinoma (ADC) (53.87%). Negative carbohydrate antigen (CA) 125, ferritin (FERR), squamous cell carcinoma antigen (SCC), and soluble fragment of cytokeratin 19 (CYFRA 21-1) levels were significantly associated with EGFR mutations. + + + + 31707279 + + + + + + + + 2020 + 8 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 8 + 1 + 14 + 45 + 0 + + + + + + + 18 + Depatuxizumab mafodotin (depatux-m) is an antibody-drug conjugate (ADC) designed for the treatment of tumors expressing epidermal growth factor receptor (EGFR). + + + + 30990907 + + + + + + + + 2020 + 8 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 8 + 1 + 14 + 37 + 0 + + + + + + + 18 + Mounting evidence now suggests an increase in the level of activated EGFR (p-EGFR/EGFR) in the adult brains of neurodegenerative diseases, as well as brain and spinal cord injuries. This activation and upregulation of EGFR are reported in both reactive astrocytes and neurons. [review] + + + + 32350120 + + + + + + + + 2020 + 8 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 8 + 1 + 14 + 17 + 0 + + + + + + + 18 + EGFR expression is significantly higher in human papilloma virus positive inverted papilloma. Stathmin is expressed by all IP tumour cells. Stathmin was also associated with dysplasia. + + + + 31710049 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 12 + 40 + 0 + + + + + + + 18 + Data indicate the localization of adenylate cyclase activating polypeptide 1 (PACAP), its receptor PACAP type I receptor (PAC1R) and epidermal growth factor receptor (EGFR) in human corneal endothelium. + + + + 30548314 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 12 + 4 + 0 + + + + + + + 18 + we found that the expression of MGAT1 is higher in glioblastoma compared to normal brain tissues. Inhibition of EGFR signalling pathway or serum starvation reduces MGAT1 expression. Knockdown of MGAT1 inhibits glioma cell proliferation and migration. + + + + 31494931 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 11 + 39 + 0 + + + + + + + 18 + Study found EGFR mutation as an independent prognostic factor for for the long-term outcomes (overall survival) of patients with resected lung adenocarcinoma. + + + + 31215177 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 10 + 52 + 0 + + + + + + + 18 + In this study, molecular dynamics simulations and free energy calculations were carried out on EAI001 and EAI045 in complex with EGFR, revealing the detailed inhibitory mechanism of EAI001 and EAI045 as EGFR allosteric inhibitor, which was expected to provide a basis for rational drug design of the EGFR allosteric inhibitors. + + + + 30499387 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 10 + 31 + 0 + + + + + + + 18 + This study shows that SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor. + + + + 31492760 + + + + + + + + 2020 + 7 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 25 + 10 + 13 + 0 + + + + + + + 18 + Found a statistically significant association between MGMT protein expression and promoter methylation status as well as between EGFR protein expression and EGFR amplification in adult patients with newly diagnosed resected glioblastoma. However, Only MGMT promoter methylation was statistically significantly associated with progression-free and overall survival. + + + + 31823165 + + + + + + + + 2020 + 7 + 18 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 18 + 11 + 14 + 0 + + + + + + + 18 + EGFRvIII-mediated epigenetic suppression of ARHI promoted glioma cell proliferation and migration via upregulating EZH2 + + + + 31751560 + + + + + + + + 2020 + 7 + 18 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 18 + 11 + 4 + 0 + + + + + + + 18 + 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment + + + + 31492173 + + + + + + + + 2020 + 7 + 18 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 18 + 11 + 2 + 0 + + + + + + + 18 + Myocardial tissues from patients with ischemic heart disease showed increased ERBB1 protein expression. + + + + 31794514 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 12 + 55 + 0 + + + + + + + 18 + By the sustained stimulation of epidermal growth factor receptor (EGFR). + + + + 31694343 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 12 + 43 + 0 + + + + + + + 18 + High EGFR expression is associated with glioblastoma. + + + + 32134157 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 11 + 49 + 0 + + + + + + + 18 + In head and neck squamous cell carcinoma, S100A8/A9 is directly associated with cellular differentiation and appears to promote caspase-3/7-mediated cleavage of EGFR, which could explain why patients with S100A8/A9-high tumors survive longer + + + + 31345374 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 11 + 43 + 0 + + + + + + + 18 + A PD-L1 tumor proportion score >/= 50% was more frequent in non-small cell lung cancer patients harboring uncommon EGFR mutations and was associated with pembrolizumab efficacy. + + + + 32211792 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 10 + 46 + 0 + + + + + + + 18 + Quantification of longitudinal plasma EGFR T790M mutation by droplet digital polymerase chain reaction assay may allow noninvasive assessment of drug resistance and guide follow-up treatment for tyrosine kinase inhibitor treated patients. + + + + 31691892 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 10 + 30 + 0 + + + + + + + 18 + Activation of A2B receptor mediates gamma-radiation-induced translocation of EGFR and phosphorylation of src and EGFR, thereby promoting recovery of irradiated lung cancer cells from DNA damage + + + + 31678144 + + + + + + + + 2020 + 7 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 7 + 11 + 10 + 28 + 0 + + + + + + + 18 + High EGFR expression is associated with glioblastoma. + + + + 30590711 + + + + + + + + 2020 + 7 + 4 + 10 + 3 + 0 + + + + + + + + + 2020 + 7 + 4 + 12 + 34 + 0 + + + + + + + 18 + Liquid biopsy shows potential for prediction of EGFR-TKI efficacy and elucidation of clonal tumor evolution during targeted therapy. + + + + 31503343 + + + + + + + + 2020 + 7 + 4 + 10 + 3 + 0 + + + + + + + + + 2020 + 7 + 4 + 11 + 39 + 0 + + + + + + + 18 + Ageing, pneumonia and gastroesophageal reflux are linked with developing EGFR mutation in lung cancer. + + + + 31634646 + + + + + + + + 2020 + 6 + 20 + 10 + 2 + 0 + + + + + + + + + 2020 + 6 + 20 + 12 + 58 + 0 + + + + + + + 18 + ULK-1 with EGFR can predict early impairment in DN while PDCN can highlight progressive diabetic nephropathy (DN) risk EGFR and PDCN may interact synergistically with ULK-1 in autophagy dysregulation as a pathogenic mechanism of DN induction and progression. + + + + 30545560 + + + + + + + + 2020 + 6 + 20 + 10 + 2 + 0 + + + + + + + + + 2020 + 6 + 20 + 12 + 49 + 0 + + + + + + + 18 + the presence of concomitant EGFR mutation can affect the tyrosine kinase inhibitors response of KRAS-mutated cells. + + + + 32130260 + + + + + + + + 2020 + 6 + 20 + 10 + 2 + 0 + + + + + + + + + 2020 + 6 + 20 + 12 + 38 + 0 + + + + + + + 18 + Molecular dynamic studies have revealed the conformational changes in the EGFR-compound 2complex during the 25 ns simulation time frame. + + + + 31814499 + + + + + + + + 2020 + 6 + 20 + 10 + 2 + 0 + + + + + + + + + 2020 + 6 + 20 + 12 + 8 + 0 + + + + + + + 18 + The oncogenic effects of CSN5 on OS cells were EGFR dependent. + + + + 31560888 + + + + + + + + 2020 + 6 + 20 + 10 + 2 + 0 + + + + + + + + + 2020 + 6 + 20 + 11 + 21 + 0 + + + + + + + 18 + CD44v9 promoted cell proliferation, and EGFR inhibition attenuated CD44v9 protein expression through downregulation of the AKT and the ERK signalling pathways, leading to preferential suppression of CD44v9-positive cells + + + + 31607750 + + + + + + + + 2020 + 6 + 13 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 13 + 12 + 23 + 0 + + + + + + + 18 + rs11569017 single nucleotide polymorphism (SNP) in the EGF gene showed significant association with end-stage renal disease (ESRD) but not with allograft rejection (AR). rs11568835 in the EGF gene showed significant association with susceptibility to AR but not with ESRD. rs1050171 in the EGFR gene showed significant association with susceptibility to AR but not with ESRD in the Korean population. + + + + 31906817 + + + + + + + + 2020 + 6 + 13 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 13 + 12 + 6 + 0 + + + + + + + 18 + Compared with 212 EGFR wild-type non-small-cell lung cancer (NSCLC), outcomes with programmed cell death 1 or programmed death-ligand 1 (PD-(L)1) blockade were worse in patients with NSCLC harboring alterations in exon 19 of EGFR (EGFRDelta19) but similar for EGFRL858R NSCLC. EGFRT790M status and PD-L1 expression did not impact response or survival outcomes to immune checkpoint blockade. + + + + 31086949 + + + + + + + + 2020 + 6 + 13 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 13 + 11 + 39 + 0 + + + + + + + 18 + HaCaT keratinocytes overexpressing S100A6 had enhanced EGFR, phospho EGFR, and phospho extracellular signal-regulated kinase 1/2 (pERK1/2) staining intensity and level coupled to higher signal transducer and activator of transcription 3 (STAT3) activity. + + + + 30805941 + + + + + + + + 2020 + 6 + 13 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 13 + 10 + 32 + 0 + + + + + + + 18 + Study revealed that miR-145-5p overexpression inhibited tumorigenesis in CRC by downregulating RHBDD1 via suppressing the EGFR-associated signaling pathway (EGFR/Raf/MEK/ERK cascades). + + + + 31693935 + + + + + + + + 2020 + 6 + 13 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 13 + 10 + 13 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) copy number gain may be associated with inferior outcomes in young adults with newly diagnosed, IDH-WT GBM, suggesting a potential role for targeting EGFR in this population. + + + + 31542863 + + + + + + + + 2020 + 6 + 6 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 6 + 13 + 19 + 0 + + + + + + + 18 + EGFR positivity was defined as the presence of mutation and EGFR negativity was defined as wild-type EGFR. EGFR positivity was 38.0%, with the incidence of mutations in E18, E19, E20, and E21 was 3.6%, 51.0%, 3.4%, and 42.0%, respectively. The EGFR positive group survived significantly longer than the negative group (p<0.001), and there was a significant difference in survival among the four EGFR mutation sites + + + + 32053675 + + + + + + + + 2020 + 6 + 6 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 6 + 11 + 35 + 0 + + + + + + + 18 + These findings suggested a PKG II-specific phosphorylation site on EGFR. + + + + 31395339 + + + + + + + + 2020 + 6 + 6 + 10 + 3 + 0 + + + + + + + + + 2020 + 6 + 6 + 10 + 15 + 0 + + + + + + + 18 + 3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR. + + + + 30810849 + + + + + + + + 2020 + 5 + 30 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 30 + 13 + 48 + 0 + + + + + + + 18 + EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. + + + + 31741433 + + + + + + + + 2020 + 5 + 30 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 30 + 13 + 0 + 0 + + + + + + + 18 + Hydrogen bond analysis of the EGFR-ErbB3 heterodimer related to non-small cell lung cancer and drug resistance. + + + + 30593826 + + + + + + + + 2020 + 5 + 30 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 30 + 12 + 7 + 0 + + + + + + + 18 + Study found that the EGFR gene was amplified in 139/330 glioblastomas (42%), 16/26 multicentric (62%) versus 123/303 monocentric tumors (40%). The association between EGFR amplification and both multicentricity at diagnosis and higher propensity to become multicentric at recurrence is in line with the implication of EGFR signaling in glioma invasiveness. + + + + 31728885 + + + + + + + + 2020 + 5 + 30 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 30 + 11 + 59 + 0 + + + + + + + 18 + Results show that EGFR expression is low and heterogeneous in a great percentage of hepatocellular carcinoma (HCC) patients and suggest that EGFR loss facilitates some of TGF-beta pro-invasive and metastatic functions. + + + + 31465839 + + + + + + + + 2020 + 5 + 23 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 23 + 11 + 50 + 0 + + + + + + + 18 + The high expression of EGFR can be used to predict the severity of invasive breast cancer, as well as the candidate biomarkers of metastasis, and it may also be associated with poor prognosis of invasive breast cancer patients. + + + + 30431376 + + + + + + + + 2020 + 5 + 23 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 23 + 11 + 2 + 0 + + + + + + + 18 + This study demonstrated that EGFR mutations are frequent in resectable lung cancer and contribute to the long-term survival outcomes of lung adenocarcinoma (LUAD) patients. The levels of tumor immune cell infiltrates in LUAD and lung squamous carcinoma differed and, in part, were significantly related to EGFR expression. + + + + 31746315 + + + + + + + + 2020 + 5 + 23 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 23 + 10 + 34 + 0 + + + + + + + 18 + AXL degradation in combination with EGFR inhibition can delay and overcome acquired resistance in human non-small cell lung cancer cells. + + + + 31043587 + + + + + + + + 2020 + 5 + 16 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 16 + 13 + 0 + 0 + + + + + + + 18 + Our results demonstrated that the lncRNALOXL1-AS1/miR-let-7a-5p/EGFR axis significantly affected proliferation, migration, and apoptosis of drug-resistant DU-145 Cells, which may provide us with a potential treatment strategy for drug-resistant prostate cancer (PCa) patients + + + + 31188543 + + + + + + + + 2020 + 5 + 16 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 16 + 12 + 25 + 0 + + + + + + + 18 + Loss of heterozygosity (LOH) was analyzed in a cohort of EGFR-mutated non-small-cell lung cancer (NSCLC) patients who were positive or negative for EGFR mutations in their cfDNA. Patients carrying KRAS mutations were also analyzed. In EGFR-negative post-tyrosine-kinase-inhibitor (TKI) cfDNAs, LOH frequency was significantly higher than in both pre- and post-TKI EGFR-positive cfDNAs. + + + + 31861832 + + + + + + + + 2020 + 5 + 16 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 16 + 10 + 7 + 0 + + + + + + + 18 + These data suggest that lapatinib-induced AnxA6 expression and accumulation of cholesterol in late endosomes constitute an adaptive mechanism for EGFR-expressing triple-negative breast cancer (TNBC) cells to overcome prolong treatment with EGFR-targeted TKIs and can be exploited as an option to inhibit and/or monitor the frequently observed acquired resistance to these drugs. + + + + 30590459 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 13 + 52 + 0 + + + + + + + 18 + characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients + + + + 31314158 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 12 + 57 + 0 + + + + + + + 18 + this study reveals 8.6% of EGFR mutation rate in the cytology specimens from the patients with primary or metastatic lung non-small cell carcinoma + + + + 30688675 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 12 + 48 + 0 + + + + + + + 18 + These findings suggest that Del19 mutations of EGFR, with an estimated frequency of 40% in Chinese lung adenocarcinoma patients, may serve as unique targets for immunotherapy in Chinese lung cancer patients. + + + + 31722672 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 12 + 6 + 0 + + + + + + + 18 + Study identified two concurrent non-synonymous missense mutations (G33S and N56K) mapping to domain I in or near the EGF binding pocket of the ectodomain (ECD) of EGFR in patient-derived head and neck squamous cell carcinoma (HNSCC) cells that were selected for cetuximab (CTX) resistance through repeated exposure to the agent in an effort to mimic what may occur clinically. + + + + 32069320 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 11 + 52 + 0 + + + + + + + 18 + Results indicate that epidermal growth factor receptor (EGFR) signaling and its downstream pathways play a central and ancient role in regulating sleep. + + + + 31763451 + + + + + + + + 2020 + 5 + 9 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 9 + 11 + 46 + 0 + + + + + + + 18 + optimal subset of CT radiomics features has high accuracy in predicting EGFR mutations in lung cancer + + + + 32187913 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 12 + 23 + 0 + + + + + + + 18 + SGLT1 depletion results in decreased levels of phospho-EGFR, and as a result, the activity of downstream signalling pathways (such as AKT and ERK) is inhibited. Hence, targeting SGLT1 itself or the EGFR-SGLT1 interaction may provide novel therapeutics against triple-negative breast cancer. + + + + 31199048 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 12 + 5 + 0 + + + + + + + 18 + We screened a panel of cancer cell surface markers and identified intercellular adhesion molecule-1 (ICAM1) and epithelial growth factor receptor (EGFR) as optimal candidates for triple-negative breast cancer (TNBC) complementary targeting. We engineered a dual complementary liposome (DCL) that precisely complements the molecular ratio and organization of ICAM1 and EGFR specific to TNBC cell surfaces. + + + + 30906868 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 12 + 5 + 0 + + + + + + + 18 + The urea cycle may be a novel metabolic vulnerability in the context of EGFR inhibition. + + + + 30808730 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 11 + 40 + 0 + + + + + + + 18 + The PRDX4 expression and EGFR mutation status were significantly associated with the prognosis of patients with stage I lung adenocarcinoma, and EGFR mutations affected the role of PRDX4 in the proliferation of lung adenocarcinoma cells. + + + + 31588184 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 10 + 57 + 0 + + + + + + + 18 + EGFR/ERBB2 germline mutations were found to be rare in Chinese lung cancer patients with more diversity other than the previously reported EGFR-T790M, with EGFR-K757R being the most common EGFR germline mutation. + + + + 30610926 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 10 + 15 + 0 + + + + + + + 18 + Data suggest that overexpression of GGA2 in LUAD tumors results in the accumulation of EGFR protein and increased EGFR signaling, which helps drive tumor progression. + + + + 30578931 + + + + + + + + 2020 + 5 + 2 + 10 + 3 + 0 + + + + + + + + + 2020 + 5 + 2 + 10 + 9 + 0 + + + + + + + 18 + neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner + + + + 31614143 + + + + + + + + 2020 + 4 + 25 + 10 + 3 + 0 + + + + + + + + + 2020 + 4 + 25 + 12 + 36 + 0 + + + + + + + 18 + The activating an EGFR-dependent polarity pathway promotes functional rescue of dystrophin-deficient satellite cells and enhances muscle force generation. + + + + 30713094 + + + + + + + + 2020 + 4 + 25 + 10 + 3 + 0 + + + + + + + + + 2020 + 4 + 25 + 12 + 26 + 0 + + + + + + + 18 + When mutations in EGFR pathway genes were analyzed continuously, higher mutant allele frequency correlated with poorer outcomes. + + + + 30487126 + + + + + + + + 2020 + 4 + 25 + 10 + 3 + 0 + + + + + + + + + 2020 + 4 + 25 + 12 + 24 + 0 + + + + + + + 18 + In combination with gefitinib for the treatment of patients harboring EGFR-mutant NSCLC tumors. + + + + 31610280 + + + + + + + + 2020 + 4 + 25 + 10 + 3 + 0 + + + + + + + + + 2020 + 4 + 25 + 11 + 51 + 0 + + + + + + + 18 + We found that there was an association between depth tumour invasion and tumour size with EGFR [ Epidermal Growth Factor Receptor ] expression, suggesting that most EGFR positive colorectal carcinomas are large and show deeper invasion by the tumours. Thus, EGFR positive tumours most likely have poor prognosis. + + + + 32150626 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 12 + 54 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) mutation leads to an up-regulation of immune response related pathways and dismal prognosis in lower-grade glioma. Infiltration of CD4+ T cells, neutrophils, macrophages, and dendritic cells is increased in EGFR-mutant cases. Infiltration of specific types of immune cells is correlated with shorter survival time. + + + + 31801484 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 12 + 45 + 0 + + + + + + + 18 + Study demonstrated that EVI1 regulated EGFR transcription and affected the proliferation of glioblastoma cells. Further, we found that both TC-rich stretches in the EGFR promoter were essential for the EVI1 regulation of EGFR transcription. + + + + 31617054 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 11 + 49 + 0 + + + + + + + 18 + In our study, 56 per cent were found to be EGFR mutated, 22.5 per cent were non-mutated and others were not tested for EGFR mutation due to non-availability of tissue.A high proportion of EGFR-positive patients were non-smokers; on the other hand, majority of patients without mutation were smokers. + + + + 31571631 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 10 + 52 + 0 + + + + + + + 18 + KRAS mutations were the most common genetic alterations involving 22.1% of the cases and being mutually exclusive with the EGFR mutations, which were found in 12.6% of them. + + + + 31711449 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 10 + 15 + 0 + + + + + + + 18 + The results revealed that miRNA128b regulated EGFR expression in in nonsmall cell lung cancer cells. + + + + 31638205 + + + + + + + + 2020 + 4 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 11 + 10 + 9 + 0 + + + + + + + 18 + High expression level of both EGFR and MET proteins was associated with markedly poor prognosis in oral squamous cell carcinoma + + + + 31762177 + + + + + + + + 2020 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 4 + 12 + 1 + 0 + + + + + + + 18 + These results indicated that VEGFR-1 regulated EGF-R expression to promote proliferation activity in a cell-autonomous-dependent manner. + + + + 31717527 + + + + + + + + 2020 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 4 + 10 + 26 + 0 + + + + + + + 18 + These results supported that PDK1 contributes to chemoresistance of ovarian cancer by activating EGFR + + + + 30229902 + + + + + + + + 2020 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 4 + 4 + 10 + 11 + 0 + + + + + + + 18 + TAS-121 is a novel third-generation EGFR-TKI and demonstrates antitumor activities in patients with Non Small Cell Lung Carcinoma expressing either common or uncommon EGFR mutations. + + + + 30872380 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 12 + 43 + 0 + + + + + + + 18 + Utilisation of supernatant cytology cfDNA in CSF will allow us to perform both EGFR mutation analysis and cytopathological diagnosis at the same time. This represents a new role of cytology in patient treatment, based on assured sample quality + + + + 30471155 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 11 + 41 + 0 + + + + + + + 18 + Response rate (RR), progression-free survival (PFS) and overall survival (OS) were increasingly improved in patients with RAS wild-type, RAS/BRAF wild-type or quadruple (KRAS/NRAS/BRAF/PIK3CA) wild-type tumours treated with anti-EGFR, assessed by standard-of-care. + + + + 30689692 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 11 + 12 + 0 + + + + + + + 18 + Data show that in the mutant kinase, a salt bridge between E762 and K745, which is key for epidermal growth factor receptor (EGFR) activity, was stabilized during the simulation. + + + + 31536605 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 10 + 25 + 0 + + + + + + + 18 + This study developed and validated a novel nomogram, incorporating epidermal growth factor receptor mutation status and treatments, for predicting 1-year and 2-year survival probability of patients with advanced adenocarcinoma. + + + + 31419239 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 10 + 25 + 0 + + + + + + + 18 + Investigated the role of epidermal growth factor receptor(EGFR) in mediating hepatitis B virus-sodium taurocholate cotransporting polypeptide(HBV-NTCP) internalization into susceptible cells. Results show EGFR acts a link from cell-surface HBV-NTCP attachment to viral invasion beyond the host cell membrane. + + + + 30952782 + + + + + + + + 2020 + 3 + 28 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 28 + 10 + 24 + 0 + + + + + + + 18 + Head and neck squamous cell carcinoma (HNSCC) are fast-growing tumours for which treatment must not be delayed. Clinical tumour growth rates are influences by EGFR, KI67 and CD44 expression. + + + + 30782931 + + + + + + + + 2020 + 3 + 21 + 10 + 2 + 0 + + + + + + + + + 2020 + 3 + 21 + 11 + 18 + 0 + + + + + + + 18 + EGFR and KRAS mutations were found in 10.7% and 16.6% of all histologies, respectively, and in 14.9% and 21.9% of adenocarcinomas. At 4.5 years median follow-up, KRAS status was an independent negative prognostic factor for overall survival (OS, p=0.016). KRAS mutations conferred 80% increased risk of death in patients receiving first-line treatment + + + + 31659106 + + + + + + + + 2020 + 3 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 3 + 14 + 12 + 23 + 0 + + + + + + + 18 + This study demonstrates that LAMC2 silencing suppresses the activity of the EGFR signaling pathway, thus functioning as a tumor suppressor in Cholangiocarcinoma. + + + + 31345467 + + + + + + + + 2020 + 3 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 3 + 14 + 11 + 5 + 0 + + + + + + + 18 + Study demonstrated that EGFR stimulation dose- and time-dependently augmented T47D breast cancer cell glucose uptake in a manner accompanied by increased lactate production, thus indicating enhanced glycolytic flux. + + + + 31532771 + + + + + + + + 2020 + 3 + 14 + 10 + 2 + 0 + + + + + + + + + 2020 + 3 + 14 + 10 + 57 + 0 + + + + + + + 18 + Pleural effusion might be a poor prognosis factor for advanced EGFR-mutant NSCLC patients without brain metastasis treated with first-generation EGFR-tyrosine kinase inhibitors. Further precision medicine according to the metastatic site is required. + + + + 30672656 + + + + + + + + 2020 + 3 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 7 + 12 + 29 + 0 + + + + + + + 18 + TargetScan analysis indicated EGFR to be the potential target of miR-133 in A549 cells. Analysis of EGFR expression in lung cancer cell lines showed up to 4.6 fold upregulation of EGFR. + + + + 31424644 + + + + + + + + 2020 + 3 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 7 + 12 + 16 + 0 + + + + + + + 18 + EGFR mutations were closely associated with lepidic predominant (65%, P = 0.56) but less commonly associated with solid predominant with mucin production adenocarcinoma (24%, P = 0.02). There was no significant difference in survival between EGFR gene mutation-positive and negative groups (P = 0.402). + + + + 30648815 + + + + + + + + 2020 + 3 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 7 + 10 + 59 + 0 + + + + + + + 18 + Median progression-free survival (PFS) was 10.4 months (95% CI 7.3-13.4) in the anti-EGFR containing regimens group and 9.7 months (8.2-11.1) in the anti-VEGF containing regimens group (p=0.037); however, median overall survival (OS) was 18.4 months (95% CI 11.7-25.1) in the anti-EGFR containing regimens group and 19.3 months (95% CI 15.7-22.9) in the anti-VEGF containing regimens group (p=0.635). + + + + 31646798 + + + + + + + + 2020 + 3 + 7 + 10 + 3 + 0 + + + + + + + + + 2020 + 3 + 7 + 10 + 30 + 0 + + + + + + + 18 + The two signaling pathways of EGFR and IL-6R have a synergistic effect on the progression of non-small cell lung cancer. + + + + 30132982 + + + + + + + + 2020 + 2 + 29 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 29 + 12 + 46 + 0 + + + + + + + 18 + We find that the proteinase ADAM17 activates the extracellular signal-regulated kinases (ERK1/2) pathway by the shedding of growth factors which triggers the formation of an endocytic entry platform. Infectious endocytic entry platforms carrying virus particles consist of two-fold larger CD151 domains containing the EGFR. Our finding clearly dissects initial virus binding from ADAM17-dependent assembly of a HPV/CD151/EGFR + + + + 31107240 + + + + + + + + 2020 + 2 + 29 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 29 + 12 + 15 + 0 + + + + + + + 18 + The EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung subtype. + + + + 31518089 + + + + + + + + 2020 + 2 + 29 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 29 + 11 + 6 + 0 + + + + + + + 18 + New or increased pleural effusions were observed in 56% of patients. No radiologic responses were observed, although several EGFR-mutant TKI-resistant patients (26%) had prolonged stable disease over 6 months. The combination reduced the EGFR mutation and T790M variant allele frequency in cell-free DNA + + + + 30880334 + + + + + + + + 2020 + 2 + 29 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 29 + 10 + 48 + 0 + + + + + + + 18 + Circulating tumor cell EGFR expression was significantly increased with regorafenib at the time of disease progression, suggesting this to be a mode of resistance. + + + + 31821662 + + + + + + + + 2020 + 2 + 22 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 22 + 12 + 55 + 0 + + + + + + + 18 + Studied association of prognosis and survival in gastric cancer patients with regards to phosphatase and tensin homolog (PTEN), epidermal growth factor receptor (EGFR), erb-b2 receptor tyrosine kinase 2 (HER-2), and insulin like growth factor 1 receptor (IGF-1R) expression. + + + + 31318186 + + + + + + + + 2020 + 2 + 22 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 22 + 11 + 51 + 0 + + + + + + + 18 + The differences in the mean allele fraction of EGFR T790M may determine different responses to TKI therapy in NSCLC patients harboring dual mutations. + + + + 31696302 + + + + + + + + 2020 + 2 + 22 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 22 + 11 + 21 + 0 + + + + + + + 18 + CLP suppresses growth and migration by attenuating cell cycle of TNBC cell lines via EGFR and CD151 signaling. + + + + 31669320 + + + + + + + + 2020 + 2 + 22 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 22 + 10 + 34 + 0 + + + + + + + 18 + Colorectal cancer tissues showed increased microvascular density and EGFR expression, activated ERK signaling, and miR-7 downregulation. EGFR was a target gene of miR-7. miR-7 overexpression and EGFR silencing decreased vasculogenic mimicry density, cell migration, and cell invasion, but increased cell apoptosis. + + + + 30909065 + + + + + + + + 2020 + 2 + 15 + 10 + 3 + 0 + + + + + + + + + 2020 + 2 + 15 + 12 + 38 + 0 + + + + + + + 18 + The overall discordance rate in EGFR mutation between primary lung tumor and paired distant metastases in non-small-cell lung cancer is low, although higher discordance rates were observed in bone metastases compared with CNS and lung/pleural metastases. Future studies assessing the impact of EGFR mutation discordance on treatment outcomes are required. + + + + 31216329 + + + + + + + + 2020 + 2 + 15 + 10 + 3 + 0 + + + + + + + + + 2020 + 2 + 15 + 11 + 40 + 0 + + + + + + + 18 + reviews the pathogenesis, amino acid sequence variants and current management of EGFR exon 20 insertion mutant NSCLC [review] + + + + 32023765 + + + + + + + + 2020 + 2 + 15 + 10 + 3 + 0 + + + + + + + + + 2020 + 2 + 15 + 10 + 31 + 0 + + + + + + + 18 + Human lung epithelial cells, BEAS-2B, exhibited EGFR transactivation by TNF via cleavage of heparin-binding (HB)-EGF by TACE and was thereby protected from TNF-induced apoptosis. + + + + 31426531 + + + + + + + + 2020 + 2 + 8 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 8 + 11 + 26 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small cell lung cancer. + + + + 30565433 + + + + + + + + 2020 + 2 + 8 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 8 + 11 + 8 + 0 + + + + + + + 18 + MUC21 proteins with a specific glycosylation status may be involved in the progression of EGFR-mutated lung adenocarcinomas, particularly at the stage where tumors are transforming from pure lepidic to micropapillary through low papillary lepidic lesions. + + + + 30973916 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 12 + 25 + 0 + + + + + + + 18 + This work has defined EGFR mutations and AKT phosphorylation as markers for sensitivity to combined MCL-1 and BCL-2/xL targeted therapy and establishes a rationale to explore multiple BCL-2 family members in patients who are refractory to EGFR inhibitor treatment. Our data support the design of a clinical trial that aims to employ inhibitors of the BCL-2 family of proteins in lung cancer patients. + + + + 31150457 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 12 + 15 + 0 + + + + + + + 18 + The alteration in ATF1 expression induced a change in the epidermal growth factor receptor (EGFR) and matrix metalloproteinases (MMP)-2 expression level in the same tendency. Thus, we provided a potential new candidate for therapies against lung cancer, showing the possible mechanism underlying the invasion and migration of lung cancer cells + + + + 31420907 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 11 + 40 + 0 + + + + + + + 18 + With advanced EGFR-positive non-small-cell lung cancer. + + + + 31298572 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 11 + 31 + 0 + + + + + + + 18 + In a systems-biology approach, we developed a mathematical model for growth-driving signaling (S) and metabolic (M) pathways, defining cancer-specific S-M interconnected networks (SMINs) in mutated EGF receptor (EGFRvIII) compared to wild-type EGF receptor (EGFRwt) expressing glioblastoma multiforme. + + + + 31386654 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 11 + 29 + 0 + + + + + + + 18 + Newly diagnosed patients with EGFR mutation-positive, advanced non-small-cell lung cancer received oral dacomitinib. + + + + 31313942 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 11 + 27 + 0 + + + + + + + 18 + Authors experimentally established acquired osimertinib-resistant cell lines from EGFR-mutant NSCLC cell lines and investigated the molecular profiles of resistant cells to uncover the mechanisms of acquired resistance. + + + + 30463991 + + + + + + + + 2020 + 2 + 1 + 10 + 2 + 0 + + + + + + + + + 2020 + 2 + 1 + 11 + 22 + 0 + + + + + + + 18 + our findings that KLF4 induces the development of SR and it cooperates with EGFR to form a positive feedback loop to amplify their SR-inducing abilities have rarely been reported. Our findings bear possible implications for the improvement of the efficacy of sorafenib in hepatocellular carcinoma (HCC). + + + + 31465134 + + + + + + + + 2020 + 1 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 25 + 14 + 49 + 0 + + + + + + + 18 + We evaluated the clinical characteristics of BRAF(non-V600E) MTs vs. those of other MTs in the EGFR signaling pathway, including BRAF(V600E) . + + + + 30963570 + + + + + + + + 2020 + 1 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 25 + 13 + 55 + 0 + + + + + + + 18 + The GBN further showed reduced level of p-epidermal growth factor receptor. + + + + 31167205 + + + + + + + + 2020 + 1 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 25 + 11 + 55 + 0 + + + + + + + 18 + Sinonasal inverted papilloma and sinonasal oncocytic papilloma are two clinical entities with different genetic mutational patterns of EGFR and KRAS. Mixed types with elements of both may harbour both EGFR and KRAS mutations. + + + + 30916792 + + + + + + + + 2020 + 1 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 25 + 10 + 43 + 0 + + + + + + + 18 + Metformin may potentially enhance the therapeutic effect and increase survival in type 2 DM patients with lung cancer receiving EGFR-TKI therapy. + + + + 31409137 + + + + + + + + 2020 + 1 + 25 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 25 + 10 + 19 + 0 + + + + + + + 18 + Non-small cell lung carcinoma patients in whom an EGFR T790M mutation was detected in plasma samples demonstrated a poorer response to osimertinib than those in whom the mutation was detected in tissue specimens. + + + + 31494653 + + + + + + + + 2020 + 1 + 18 + 10 + 3 + 0 + + + + + + + + + 2020 + 1 + 18 + 12 + 47 + 0 + + + + + + + 18 + WEE1 expression was increased after EGFR-TKIs resistance. + + + + 31387179 + + + + + + + + 2020 + 1 + 18 + 10 + 3 + 0 + + + + + + + + + 2020 + 1 + 18 + 10 + 58 + 0 + + + + + + + 18 + miR-7 inhibition protects human osteoblasts from Dexamethasone via activation of EGFR signaling. + + + + 31313024 + + + + + + + + 2020 + 1 + 18 + 10 + 3 + 0 + + + + + + + + + 2020 + 1 + 18 + 10 + 57 + 0 + + + + + + + 18 + It was confirmed that Osimertinib could inhibit the proliferation of tumor cells with EGFR mutation and T790M resistance mutation in zebrafish, which was consistent with the clinical research conclusion. + + + + 31346515 + + + + + + + + 2020 + 1 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 11 + 12 + 18 + 0 + + + + + + + 18 + A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. + + + + 31017840 + + + + + + + + 2020 + 1 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 11 + 11 + 43 + 0 + + + + + + + 18 + Our results suggest that SPP1 enhanced the second-generation EGFR TKI resistance in lung cancer, and inhibiting SPP1 might be a therapeutic target to overcome afatinib resistance. + + + + 30832751 + + + + + + + + 2020 + 1 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 11 + 11 + 12 + 0 + + + + + + + 18 + EGFR T790M mutation is a major mechanism of acquired resistance to afatinib + + + + 30539501 + + + + + + + + 2020 + 1 + 11 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 11 + 10 + 52 + 0 + + + + + + + 18 + EGFR mutation testing should be performed in Asian patients with squamous cell carcinoma diagnosed from small lung biopsies + + + + 31221183 + + + + + + + + 2020 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 4 + 12 + 7 + 0 + + + + + + + 18 + The emergence of EGFR mutations determines the outcome of anti-EGFR treatment in colorectal cancer patients. + + + + 31220949 + + + + + + + + 2020 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 4 + 12 + 7 + 0 + + + + + + + 18 + Study shows that skin and keratinocytes from Kindler syndrome patients have significantly reduced expression levels of the EGFR, resulting in defective EGF-dependent signaling and cell migration. Kindlin-1 can associate directly with EGFR in vitro and in keratinocytes in an EGF-dependent manner and formation of this complex protect EGFR from lysosomal-mediated degradation and required for EGF-dependent migration. + + + + 30248333 + + + + + + + + 2020 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2020 + 1 + 4 + 11 + 43 + 0 + + + + + + + 18 + Loss of T790 M mutation at resistance was correlated with early progression and overall survival in response to osimertinib treatment in Chinese patients with NSCLC harboring acquired T790 M mutation. + + + + 30642450 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 12 + 0 + 0 + + + + + + + 18 + We have developed a clinically translatable bispecific antibody that redirects human T cells to safely and effectively treat malignant glioma. On the basis of these results, we have developed a clinical study of hEGFRvIII-CD3 bi-scFv for patients with EGFRvIII-positive malignant glioma. + + + + 29703821 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 11 + 34 + 0 + + + + + + + 18 + We identified EE02 as an EGFR/Eps8 complex inhibitor that demonstrated promising antitumor effects in breast cancer and non-small cell lung cancer (NSCLC). Our data suggest that the EGFR/Eps8 complex offers a no + + + + 31118055 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 11 + 6 + 0 + + + + + + + 18 + EGFR-mutant non-small cell lung carcinomas can undergo small cell lung carcinoma transformation. This occurs at an average of 17.8 months after diagnosis and cases are often characterized by Rb1, TP53, and PIK3CA mutations. + + + + 30550363 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 10 + 47 + 0 + + + + + + + 18 + FOXO3a activation is a crucial event in the response of glioblastoma cells to EGFR inhibition. + + + + 30980364 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 10 + 44 + 0 + + + + + + + 18 + For those cases who developed resistance with circulating DNA showing an EGFR mutation, 50% were positive for T790M that is also comparable to the international literature. + + + + 31147859 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 10 + 17 + 0 + + + + + + + 18 + Mechanistically, GPAA1 enhanced the levels of metastasis-associated GPI-anchored proteins to increase tumour metastasis and intensified lipid raft formation, which consequently promoted the interaction between EGFR and ERBB2 as well as downstream pro-proliferative signalling. + + + + 31118109 + + + + + + + + 2019 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 21 + 10 + 15 + 0 + + + + + + + 18 + prosurvival response was partially mediated through enhanced DNA repair, as EGFR or MEK/ERK inhibitors delayed DNA damage resolution + + + + 30679314 + + + + + + + + 2019 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 14 + 12 + 14 + 0 + + + + + + + 18 + extracellular domain of epithelial cell adhesion molecule -induced LIN28 expression reduces the expression of the microRNA LET7 and up-regulates that of the transcription factor high-mobility group AT-hook 2 (HMGA2), which activates the transcription of pluripotency factors. + + + + 30926604 + + + + + + + + 2019 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 14 + 12 + 9 + 0 + + + + + + + 18 + APE1 stimulates EGFR-tyrosine kinase inhibitors resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma. + + + + 30382076 + + + + + + + + 2019 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 14 + 11 + 45 + 0 + + + + + + + 18 + The T790M mutation rate was 8.4% in overall patients. The T790M mutation was more frequent in patients with brain metastasis 30.0% . We found that post-TKI (tyrosine kinase inhibitors) samples 42.8% were associated with a higher T790M mutation rate. Subgroup analysis showed that the duration of TKI therapy for 6 to 10 months 66.6% and >10 months 75.0% were also associated with higher T790M mutation rate. + + + + 30337598 + + + + + + + + 2019 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 14 + 11 + 36 + 0 + + + + + + + 18 + The expression of lncRNA EGFR-AS1 is decreased in preeclampsia patients, promoting disease progression by inhibiting EGFR-JAK/STAT signaling pathway. + + + + 30338781 + + + + + + + + 2019 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 14 + 10 + 14 + 0 + + + + + + + 18 + The esophageal squamous cell carcinoma patients with the CC genotype of PLCE1 rs17109671 and EGFR rs2072454 have poor overall survival. + + + + 31209807 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 12 + 28 + 0 + + + + + + + 18 + interactions of EGFR binding to phosphorylated Mig6-segment2. + + + + 29574142 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 12 + 5 + 0 + + + + + + + 18 + We found that both protein and gene expression levels of serum cMET, HGF and EGFR were higher in patients with lung cancer. We suggest that protein and gene expression levels of c-MET in patients with lung cancer will lead to targeted therapies as a new biomarker. + + + + 31104010 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 11 + 41 + 0 + + + + + + + 18 + Positive selection of amino acid replacements during somatic mutagenesis of EGFR gene in cancer cells. + + + + 30974384 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 11 + 33 + 0 + + + + + + + 18 + EGFR to KLF5 pathway is predictive of patient progression on platinum-based therapy. + + + + 30478887 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 11 + 11 + 0 + + + + + + + 18 + Study found that in cervical cancer patient serum and cancer tissues, EGFR is over-expressed. A small group of cervical cancer patients present mutation of EGFR exon 19 and 21, but at relatively lower incidence. Mutation rates were significantly higher in patients with highly differentiated grade, early TNM stage, and those without lymph node or distal metastasis. + + + + 30338793 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 11 + 2 + 0 + + + + + + + 18 + The RAS-PI3K interaction is an important signaling node and potential therapeutic target in EGFR-mutant lung cancer. + + + + 30590030 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 10 + 38 + 0 + + + + + + + 18 + COMMD5 participates in long-range endosome transport, including epidermal growth factor receptor (EGFR) recycling, and provides the strength to deform and assist the scission of vesicles into sorting endosomes. + + + + 30021164 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 10 + 9 + 0 + + + + + + + 18 + ALIX is a regulator of both EGFR activity and PD-L1 surface presentation in basal-like breast cancer (BLBC) cells. + + + + 30021161 + + + + + + + + 2019 + 12 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 12 + 7 + 10 + 9 + 0 + + + + + + + 18 + High EGFR expression is associated with Glioma. + + + + 31704826 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 12 + 55 + 0 + + + + + + + 18 + Extracellular vesicle-encapsulated EGFR is protected from targeted inhibitors of EGFR and can trigger signaling pathway in recipient cancer cells, promoting proliferation and migration ability in vitro. + + + + 30683316 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 12 + 3 + 0 + + + + + + + 18 + the present study suggests that the four ddPCR testing systems could be used for early detection of EGFR mutations in plasma samples, so that patients can better select the targeted drugs according to the EGFR mutation. + + + + 31115577 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 11 + 54 + 0 + + + + + + + 18 + Results provide evidence that KRAS and EGFR gene amplifications mediate resistance to the third-generation EGFR TKIs rociletinib and osimertinibin acquired Afatinib-resistant non-small cell lung cancer harboring exon 19 deletion/T790M in EGFR. + + + + 30322949 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 11 + 46 + 0 + + + + + + + 18 + High EGFR expression is associated with breast cancer progression. + + + + 30583076 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 11 + 32 + 0 + + + + + + + 18 + Our findings reveal a heterogenous pattern of resistance mechanisms to abivertinib which is distinct from that previously reported with osimertinib. EGFR amplification was the most common resistance mechanism in this cohort. + + + + 31027916 + + + + + + + + 2019 + 11 + 30 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 30 + 10 + 22 + 0 + + + + + + + 18 + Actin stabilization through the MC1R consisted of ERK1/2 dependent phosphorylation and inactivation of EGFR signaling with stabilization of synaptopodin and stress fibers in podocytes. These results further explain how patients with nephrotic syndrome show responsiveness to MC1R receptor activation by decreasing EGFR signaling + + + + 30356069 + + + + + + + + 2019 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 23 + 12 + 49 + 0 + + + + + + + 18 + We present comprehensive mutation profiles of a large cohort of osimertinib-resistance lung cancer patients using mainly cfDNA. Besides C797 mutations, novel secondary mutations of EGFR L718 and L792 residues confer osimertinib resistance, both in vitro and in vivo, and are of great clinical and pharmaceutical relevance. + + + + 29506987 + + + + + + + + 2019 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 23 + 12 + 24 + 0 + + + + + + + 18 + EGFR-mutant lung cancers harbor a spectrum of concurrent alterations that have prognostic and predictive significance. By utilizing paired samples, we identified several novel acquired alterations that may be relevant in mediating resistance, including an activating mutation in MTOR further validated functionally. + + + + 29530932 + + + + + + + + 2019 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 23 + 11 + 42 + 0 + + + + + + + 18 + In this article, we discuss the nature of EGFR mutation heterogeneity in NSCLC and review recent preclinical and clinical data that have assessed the sensitivity of different mutations to different EGFR tyrosine kinase inhibitors + + + + 31558282 + + + + + + + + 2019 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 23 + 11 + 25 + 0 + + + + + + + 18 + Our study reveals that different combinations of TP53, EGFR, and STK11 mutations, together with PD-L1 expression by tumor cells, represent robust parameters to identify best responders to PD-1 blockade. + + + + 29764856 + + + + + + + + 2019 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 23 + 10 + 7 + 0 + + + + + + + 18 + Our data demonstrated that co-targeting EGFR and IKKbeta with Gefitinib and IKKbeta inhibitors could provide a potential novel therapy for head and neck squamous cell cancer. + + + + 30585254 + + + + + + + + 2019 + 11 + 16 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 16 + 13 + 0 + 0 + + + + + + + 18 + treating primary cytotrophoblasts with therapeutics which have been previously found to reduce sFlt-1 secretion, either reduced EGFR signaling (esomeprazole and statins) or perturbed mitochondrial function (esomeprazole, resveratrol, and metformin). Additionally, targeting both pathways simultaneously produced additive reductions in sFlt-1 secretion + + + + 30636550 + + + + + + + + 2019 + 11 + 16 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 16 + 11 + 41 + 0 + + + + + + + 18 + Targeting activated EGFR may inhibit both EMT and PD-L1. + + + + 29954240 + + + + + + + + 2019 + 11 + 16 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 16 + 10 + 23 + 0 + + + + + + + 18 + Mechanistically, FoxM1/ADAM17 axis activated the EGFR/AKT/GSK3beta signaling pathway and ADAM17/EGFR/GSK3beta axis could maintain FoxM1 stability in glioma cells. + + + + 29700308 + + + + + + + + 2019 + 11 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 11 + 9 + 11 + 25 + 0 + + + + + + + 18 + Matrix stiffness regulates keratinocyte proliferation and is mediated by EGF signaling. + + + + 29669739 + + + + + + + + 2019 + 11 + 2 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 2 + 12 + 6 + 0 + + + + + + + 18 + YTHDF2 may act as a tumor suppressor to repress cell proliferation and growth by destabilizing the EGFR mRNA in hepatocellular carcinoma cells. + + + + 30423408 + + + + + + + + 2019 + 11 + 2 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 2 + 11 + 27 + 0 + + + + + + + 18 + The expressions of VEGF, HIF-1alpha, and EGFR are the highest in Marjolin ulcer canceration area, and EGFR may promote angiogenesis through HIF-1alpha or directly increasing the expression of VEGF. + + + + 31594186 + + + + + + + + 2019 + 11 + 2 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 2 + 11 + 6 + 0 + + + + + + + 18 + The impaired EGFR signaling and its effects on epidermal differentiation were also observed in familial AI patients and Ncstn(DeltaKC) mice. Thus, our study showed that miR-30a-3p/RAB31/EGFR signaling pathway may play a key role in the pathogenesis of familial AI with NCSTN mutations. + + + + 30120935 + + + + + + + + 2019 + 11 + 2 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 2 + 10 + 58 + 0 + + + + + + + 18 + EGFR endocytosis is dysregulated in advanced SCC and correlates with anti-EGFR monoclonal antibody therapy outcomes. In actinic keratosis, intraepidermal carcinoma, and well-differentiated cutaneous squamous cell carcinoma, different patterns of epidermal growth factor ligand uptake and binding were observed at the leading edge of different dysplastic lesions, suggesting that these differences in EGFR endocytosis might in + + + + 30077724 + + + + + + + + 2019 + 11 + 2 + 10 + 3 + 0 + + + + + + + + + 2019 + 11 + 2 + 10 + 50 + 0 + + + + + + + 18 + The pY291-Fas is essential for the EGF-induced formation of the Fas-mediated nuclear EGFR/STAT3 signaling complex. + + + + 30127519 + + + + + + + + 2019 + 10 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 26 + 12 + 29 + 0 + + + + + + + 18 + EGFR-mediated kinase cascade controls the force-dependent recruitment of vinculin to stressed E-cadherin complexes - a key early signature of cadherin-based mechanotransduction. + + + + 29487179 + + + + + + + + 2019 + 10 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 26 + 11 + 33 + 0 + + + + + + + 18 + to reveal the prognostic value of TP53 in advanced non-small cell lung cancer, as well as the correlation with EGFR mutation + + + + 30089598 + + + + + + + + 2019 + 10 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 26 + 11 + 33 + 0 + + + + + + + 18 + Frequency of EGFR mutations in pulmonary adenocarcinomas of our series is similar to that found in the European ones with some particularities. The mutations detected are uncommon. + + + + 29540329 + + + + + + + + 2019 + 10 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 26 + 11 + 5 + 0 + + + + + + + 18 + The optimal prediction of EGFR mutational status in early stage LACs was achieved by using thin CT-scan slices. + + + + 30559455 + + + + + + + + 2019 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2019 + 10 + 19 + 11 + 34 + 0 + + + + + + + 18 + Monensin blunts PDAC xenograft tumor growth by suppressing cell proliferation via targeting EGFR pathway. + + + + 30559409 + + + + + + + + 2019 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2019 + 10 + 19 + 11 + 34 + 0 + + + + + + + 18 + cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells + + + + 29674627 + + + + + + + + 2019 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2019 + 10 + 19 + 11 + 7 + 0 + + + + + + + 18 + Full-length EGFR and truncated EGFRvIII work through KRAS to upregulate the chemokine CCL2 and drive macrophage infiltration in glioblastoma + + + + 30401716 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 12 + 26 + 0 + + + + + + + 18 + This article explicitly links EGFR tyrosine kinase inhibitors to the development of a specific DNA-resistant mutation through AICDA activity in lung cancer. + + + + 30333118 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 11 + 13 + 0 + + + + + + + 18 + Drugs that target HER2/EGFR protein folding, including DDAs and CsA, have the potential to kill cancers. + + + + 30718919 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 11 + 4 + 0 + + + + + + + 18 + The quantitative study of epidermal growth factor (EGF) -epidermal growth factor receptor (EGFR) complex translocation to the nucleus may help to unravel its roles in health and pathological conditions, such as cancer. + + + + 29277356 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 10 + 48 + 0 + + + + + + + 18 + because the investigation was limited to mutations in the EGFR gene, other possible resistance mechanisms such as MET amplification were not assessed in the present study. Further studies are required to fully address the mechanisms of resistance of osimertinib. + + + + 30625213 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 10 + 17 + 0 + + + + + + + 18 + TGFbeta signaling can shift from inhibiting to promoting breast cancer development via HER2/EGFR AKT-mediated phosphorylation of Smad3 at S208, enhancing its nuclear accumulation and upregulation of EMT-related genes + + + + 30171053 + + + + + + + + 2019 + 10 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 12 + 10 + 4 + 0 + + + + + + + 18 + thermodynamic analysis indicated that the hydrogen bond or Van der Waals force was the main interaction force in the process of EGFR binding to all 5 ligands. Overall, these results demonstrate that a cell membrane chromatography method could be an effective tool to investigate the binding characteristics between ligands and receptors. + + + + 29363191 + + + + + + + + 2019 + 10 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 5 + 11 + 43 + 0 + + + + + + + 18 + the obtained results suggest that ERbeta5 and EGFR synergistically promote the progression of lung cancer by activating MEK/ERK signalling pathway, which provides a theoretical basis for more accurate combined targeted therapy. + + + + 30022688 + + + + + + + + 2019 + 10 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 5 + 11 + 42 + 0 + + + + + + + 18 + This study provides an extensive characterization of human glioma cell models, including stem-like models + + + + 29953622 + + + + + + + + 2019 + 10 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 10 + 5 + 10 + 46 + 0 + + + + + + + 18 + study identifies USP43 to be an H2BK120 deubiquitinase and a potential tumor suppressor and reveals a reciprocally inhibitory loop between USP43 and EGFR/PI3K/AKT, whose imbalance drives breast carcinogenesis + + + + 30135474 + + + + + + + + 2019 + 9 + 28 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 28 + 11 + 30 + 0 + + + + + + + 18 + The EGFR L858R/T790M/L792H and L858R/T790M/G796R mutations conferred resistance to osimertinib both in vitro and in silico. + + + + 29857056 + + + + + + + + 2019 + 9 + 28 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 28 + 11 + 28 + 0 + + + + + + + 18 + Enhanced glycolysis by EGFR mutation is required for maintaining EGFR levels via inhibition of JNK-induced autophagy. This provides a promising rationale for use of JNK activators in patients with EGFR-mutated NSCLC + + + + 29945964 + + + + + + + + 2019 + 9 + 28 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 28 + 11 + 11 + 0 + + + + + + + 18 + Expressions level of VEGF and EGFR in serum of well-differentiated, moderatelydifferentiated, and poorly-differentiated RCC were all higher than those in the healthy control group. + + + + 30358217 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 12 + 40 + 0 + + + + + + + 18 + Results provide evidence that EGFR rs712829, rs2072454 SNPs, and TCCG haplotypes are associated with a risk of lung cancer among Jordanians. + + + + 30011810 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 12 + 31 + 0 + + + + + + + 18 + EGFR mutations and EGFRamp are associated with better OS, PFS, CR, and PR to erlotinib and, hence, could aid in the correct selection of patients that benefit from EGFR TKI treatment. + + + + 30284706 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 39 + 0 + + + + + + + 18 + ectopic expression of CBLC enhanced the activation of EGFR and downstream ERK1/2 signaling after ligand stimulation by competing with CBL for EGFR binding.. + + + + 29945960 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 35 + 0 + + + + + + + 18 + Targeting cholesterol combined with EGFR-TKI is potentially a novel therapeutic strategy for gefitinib resistant treatment. + + + + 29215723 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 34 + 0 + + + + + + + 18 + ADAM17/EGFR-dependent ERK activation mediated thrombin-stimulated CTGF expression in human lung fibroblasts. + + + + 29902535 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 25 + 0 + + + + + + + 18 + EGFR-mutant non-small cell lung cancer(NSCLC) is incurable despite the marked sensitivity of these tumors to EGFR TKIs. These findings identify N-linked glycosylation, a posttranslational modification common to EGFR and other oncogenic signaling proteins, as an effective therapeutic target that enhances tumor responses for EGFR-mutant NSCLC + + + + 30026325 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 7 + 0 + + + + + + + 18 + The regulation of EGF receptor (EGFR) endocytosis by two predicted miRNAs, namely miR-17 and miR-145, was confirmed experimentally. Functionally, miR-145, which blocked EGFR endocytosis, prolonged EGFR membrane signaling and altered responsiveness of colon cancer cells to EGFR-targeting drugs. + + + + 29459716 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 11 + 2 + 0 + + + + + + + 18 + EGFR driver mutations was the most common and was present in 43 lesions (52.4%) in surgical patients with Multiple Primary Lung Cancers. + + + + 29092754 + + + + + + + + 2019 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 21 + 10 + 4 + 0 + + + + + + + 18 + EGFR-Kaiso signaling axis is a critical regulator of the miR-200-ZEB1 feedback loop promoting epithelial to mesenchymal transition and metastasis in prostate cancer. + + + + 29751044 + + + + + + + + 2019 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 14 + 12 + 39 + 0 + + + + + + + 18 + In EGFR-mutant oncogene-addicted cells, blocking TNF enhances the effectiveness of EGFR inhibition. EGFR plus TNF inhibition is also effective in NSCLC with acquired resistance to EGFR inhibition. + + + + 29613856 + + + + + + + + 2019 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 14 + 11 + 43 + 0 + + + + + + + 18 + Here, the authors identified an important EGFR-interacting protein, alpha-actinin-4 (ACTN4), which is involved in maintaining and regulating the actin cytoskeleton. They observed that transactivated-EGFR competitively recruited ACTN4 from intracellular F-actin fibers to disrupt the cytoskeleton, thus facilitating bacterial invasion of brain microvascular endothelial cells. + + + + 30687645 + + + + + + + + 2019 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 14 + 11 + 2 + 0 + + + + + + + 18 + The PFS advantage of EGFR-TKI over chemotherapy in advanced EGFR mutant NCLC is not explained by depth of response at 6 or 12 weeks. + + + + 29580950 + + + + + + + + 2019 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 14 + 10 + 8 + 0 + + + + + + + 18 + Study findings suggest that in non-small cell lung cancer patients primary EGFR T790M mutation likely coexists with exon 21 L858R mutation while acquired mutation likely coexists with exon 19del. Patients with primary T790M mutation experienced greater benefits from osimertinib. However, patients with acquired T790M mutation had a better overall survival during the entire clinical treatment. + + + + 30474188 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 12 + 39 + 0 + + + + + + + 18 + EGFR effective mutation group and non-effective mutation group were statistically significant in lung adenocarcinoma patients with different gender, age, smoking history, histological type, and differentiation degree + + + + 31434406 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 12 + 33 + 0 + + + + + + + 18 + A series of novel 4-anilino quinazoline derivatives were taken based on the literature study and optimized with Autodock version 4.2 and molecular dynamics (MD) protocol to investigate the interaction between the target compounds and the amino acid residues of target protein epidermal growth factor receptor (EGFR) tyrosine kinase (PDB ID: 1M17). + + + + 31038021 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 12 + 1 + 0 + + + + + + + 18 + compound 18 and 74 have been located to be the foremost active compounds of the series with IC50 value of 0.88, 0.92 muM in cellular assay and 0.56, 0.62 muM in enzymatic assay, against double mutant L858R/T790M EGFR. Additionally, they showed much less affinity toward wild-type (WT)-EGFR with minimal cardiotoxicity + + + + 31038025 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 42 + 0 + + + + + + + 18 + The authors established a serum-based method for detection of EGFRvIII in high-grade brain tumors that might serve as an optimal noninvasive method for diagnosing EGFRvIII-positive high-grade glioma + + + + 28574310 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 10 + 0 + + + + + + + 18 + Patients with EGFR mutations or ALK rearrangements exhibited lower PD-L1 and CD8 co-expression level in TME. + + + + 30429043 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 3 + 0 + + + + + + + 18 + EGFR-mutated NSCLC patients exhibiting MET amplification. + + + + 30429039 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 3 + 0 + + + + + + + 18 + To investigate three new disease-progression modes of NSCLC patients after EGFR-TKI treatment. + + + + 30429037 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 3 + 0 + + + + + + + 18 + Serum levels of HGF, IL-6 and VEGF and its dynamic change during TKI treatment could be used to predict the efficacy of EGFR-TKIs treatment in patients with EGFR-mutant NSCLC. + + + + 30429024 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 3 + 0 + + + + + + + 18 + At the current marketed price, first-line osimertinib therapy in patients with advanced EGFR-mutant lung adenocarcinoma is not cost-effective in Canada. + + + + 30429004 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 11 + 3 + 0 + + + + + + + 18 + Study in non-small cell lung cancer patients with activating EGFR mutations treated with EGFR tyrosine kinase inhibitors (TKIs), found that gefitinib, EGFR TKIs treatment duration more than 13 months, male gender, initial liver metastasis and uncommon EGFR mutation were independent factors for secondary T790M mutation. + + + + 30485437 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 10 + 25 + 0 + + + + + + + 18 + Study data form 10,759 non-small cell lung cancer East Asian patients suggested that the EGFR T790M mutation and EGFR amplification may represent the major resistance mechanisms against targeted therapies in tumors bearing EGFR-kinase domain duplication. + + + + 30255937 + + + + + + + + 2019 + 9 + 7 + 10 + 2 + 0 + + + + + + + + + 2019 + 9 + 7 + 10 + 20 + 0 + + + + + + + 18 + microRNA-21 and microRNA-206 closely correlate with ER, PR, and HER2 expression, which can be considered as clinical biomarkers + + + + 31276668 + + + + + + + + 2019 + 8 + 31 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 31 + 12 + 59 + 0 + + + + + + + 18 + Patients with EGFR exon20ins have similar clinical characteristics. + + + + 30429031 + + + + + + + + 2019 + 8 + 31 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 31 + 12 + 17 + 0 + + + + + + + 18 + The de novo T790M EGFR mutation is a relatively unfavorable prognosis factor for lung adenocarcinoma patients receiving first-line tyrosine kinase-inhibitor treatment. + + + + 30760406 + + + + + + + + 2019 + 8 + 31 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 31 + 11 + 47 + 0 + + + + + + + 18 + MAT2B was markedly increased in osteosarcoma (OS) specimens compared with the normal bone tissues, and it was additionally abundantly expressed in OS cell lines. Inhibition of MAT2B expression caused a marked decrease in proliferation and significant increase in apoptosis. Results demonstrated that MAT2B functions as a tumor oncogene in OS in vivo and in vitro via regulation of EGFR and PCNA. + + + + 30942439 + + + + + + + + 2019 + 8 + 31 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 31 + 10 + 17 + 0 + + + + + + + 18 + In the case of CNS failure of first-line EGFR inhibition. + + + + 30392443 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 12 + 19 + 0 + + + + + + + 18 + G719S and T790M mutations are not associated with cervical cancer + + + + 30950030 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 12 + 16 + 0 + + + + + + + 18 + EGFR was significantly upregulated in the hepatocellular carcinoma tissues.MCM3AP-AS1 regulates EGFR expression. + + + + 31237446 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 12 + 16 + 0 + + + + + + + 18 + Results show that after treatment with tyrosine kinase inhibitors of EGFR, lung adenocarcinoma with EGFR mutation develops resistance through a mechanism involving USP22 which prevents ubiquitination-mediated EGFR degradation. + + + + 29981430 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 12 + 8 + 0 + + + + + + + 18 + In the largest consecutive routine Asian non-small cell lung cancer (NSCLC) cohort analyzed to date, we found that high PD-L1 expression frequently overlapped with ROS1 rearrangement, while it negatively correlated with EGFR mutations. + + + + 30475455 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 10 + 23 + 0 + + + + + + + 18 + Treated in neoadjuvant setting with EGFR tyrosine kinase inhibitor. + + + + 29895214 + + + + + + + + 2019 + 8 + 24 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 24 + 10 + 19 + 0 + + + + + + + 18 + EGFR mutations are associated with recurrence in pN0M0 lung adenocarcinoma. EGFR mutation status and histological subtype should be considered when evaluating the risk of recurrence in resected lung adenocarcinoma patients. + + + + 30298562 + + + + + + + + 2019 + 8 + 17 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 17 + 11 + 25 + 0 + + + + + + + 18 + the glioblastoma cell line 170-MG-BA exhibits a high level of EGFR amplification + + + + 30509096 + + + + + + + + 2019 + 8 + 17 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 17 + 10 + 42 + 0 + + + + + + + 18 + Adenocarcinomas with EGFR mutations had a higher GGO proportion than those with wild-type EGFR after matching of clinical variables. Lesions with an exon 21 mutation had a higher GGO proportion than lesions with other mutations. + + + + 30089595 + + + + + + + + 2019 + 8 + 17 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 17 + 10 + 32 + 0 + + + + + + + 18 + Positive EGFR mutation status is a favorable prognostic factor in patients with surgically resected Lung Adenocarcinomas; however, EGFR mutation subtype (exon 21 L858R mutation or exon 19 deletion) exhibits no prognostic impact. + + + + 28826599 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 13 + 3 + 0 + + + + + + + 18 + In modulating drug resistance to EGFR-TKI treatment. + + + + 30544036 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 12 + 21 + 0 + + + + + + + 18 + EGFR-TKIs plus local therapy showed prolonged survival benefit. + + + + 30387880 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 10 + 58 + 0 + + + + + + + 18 + Report reduced EMILIN-1 and enhanced myogenic tone, dependent on increased TGF-beta-EGFR signaling, in resistance arteries from hypertensive patients. + + + + 30354220 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 10 + 53 + 0 + + + + + + + 18 + The mRNA and protein expression levels of LRIG1 in U251 cells were up-regulated after resveratrol treatment, accompanied with decreased Epidermal Growth Factor Receptor (EGFR) + + + + 29745084 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 10 + 43 + 0 + + + + + + + 18 + Patients younger than 64 years and carriers of EGFR gene -191CC genotype have significantly higher risk for adenocarcinoma than carriers of -191CA or -191AA genotype. Further studies on larger cohorts are necessary to evaluate -191C/A SNP as a potential biomarker. + + + + 29745081 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 10 + 43 + 0 + + + + + + + 18 + Study identify MED12 as an important molecular regulator of epithelial ovarian cancer (EOC) tumor dormancy. MED12 knockout (KO) induced dormancy of EOC cells in vitro and in vivo, and microarray analysis showed that MED12 KO decreased expression of EGFR. MED12 bound to the promoter of EGFR, and MED12 expression positively correlated with EGFR expression in EOC patient samples. + + + + 29735544 + + + + + + + + 2019 + 8 + 10 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 10 + 10 + 43 + 0 + + + + + + + 18 + Study propose a new model of mutant-EGFR in non-small cell lung cancer (NSCLC) trafficking and demonstrate that clathrin inhibition induces rapid degradation across a large panel of endogenous mutant-EGFR cells resistant to the first- and second-generation EGFR inhibitors and to the third-generation TKI osimertinib. + + + + 29555874 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 13 + 8 + 0 + + + + + + + 18 + GM1 suppressed EGFR signaling. + + + + 31127673 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 12 + 32 + 0 + + + + + + + 18 + EGFR1 promoter polymorphism could be a risk factor associated with Lung Adenocarcinoma. + + + + 30912007 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 12 + 20 + 0 + + + + + + + 18 + This study documents that long-term, moderate hypoxia promotes resistance to the EGFR TKI, gefitinib, in the NSCLC cell line HCC827, which harbors an activating EGFR mutation..Mechanistically, knockdown of LSD1 and PLU-1, prevented and reversed hypoxia-induced gefitinib resistance, suggesting that LSD1 and PLU-1 play key roles in hypoxia-induced gefitinib resistance and epithelial-mesenchymal transition + + + + 29934325 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 12 + 18 + 0 + + + + + + + 18 + his study uncovers an LPA1-EGFR signaling axis that is used for cell invasion in hypoxia and suggests a potential target to impede cancer metastasis + + + + 29866927 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 11 + 50 + 0 + + + + + + + 18 + Overexpression of epidermal growth factor receptor is associated with colorectal cancer. + + + + 29688906 + + + + + + + + 2019 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2019 + 8 + 3 + 10 + 46 + 0 + + + + + + + 18 + A tumor-suppressive role of miR-1296-5p through the translational repression of oncogenic CDK6 and EGFR in gastric cancer. + + + + 30530570 + + + + + + + + 2019 + 7 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 27 + 13 + 0 + 0 + + + + + + + 18 + Via regulating EGFR/ERK-mediated EMT process. + + + + 30487162 + + + + + + + + 2019 + 7 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 27 + 12 + 18 + 0 + + + + + + + 18 + Studied association of epidermal growth factor receptor (EGFR) mutation on prognosis and recurrence of lung adenocarcinoma, and found lung adenocarcinoma with EGFR gene mutation to have longer progression and less aggressive recurrence than that with wild-type EGFR gene, especially with regard to distant metastasis. + + + + 29878144 + + + + + + + + 2019 + 7 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 27 + 12 + 15 + 0 + + + + + + + 18 + The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma. + + + + 30956990 + + + + + + + + 2019 + 7 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 27 + 11 + 0 + 0 + + + + + + + 18 + The detection rate of T790M mutations in CSF was 18.1% (2 of 11) in all cases with EGFR-sensitive mutations in the primary lung lesion. + + + + 30452286 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 12 + 44 + 0 + + + + + + + 18 + Concomitant high expression of ERalpha36, EGFR and HER2 was strongly associated with aggressive behaviors including extrathyroidal extension, lymph node metastasis and high TNM stage in papillary thyroid carcinomas. + + + + 28947799 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 12 + 40 + 0 + + + + + + + 18 + Stimulation by EGF does not appear to induce a change in the density of EGFR in local clusters but instead results in formation of EGFR-Met and EGFR-ErbB3 associations; non-canonical EGFR-Met interactions are implicated in resistance to anti-cancer drugs but have not been previously detected in drug-naive cells. + + + + 28939861 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 12 + 37 + 0 + + + + + + + 18 + EGFR binds to PS-ASOs at the cell surface and mediates essential steps for active (productive) cellular uptake of PS-ASOs through its cargo-dependent trafficking processes which migrate PS-ASOs from early to late endosomes. This EGFR-mediated process can also serve as an additional model to better understand the mechanism of intracellular uptake and endosomal release of PS-ASOs. + + + + 29514240 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 11 + 15 + 0 + + + + + + + 18 + results reveal that the stromal ECM acts as a microenvironmental cue promoting EGFR TKI resistance in lung cancer cells + + + + 30471423 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 11 + 2 + 0 + + + + + + + 18 + The crystal structure of the sdAb bound to EGFR was used to rationally select sites likely to optimally display the sdAb upon conjugation to a fluorescent nanocrystal (Qdot). Qdots with sdAb attached at the azPhe13 position showed 6 times greater binding affinity to EGFR expressing A549 cells, compared to Qdots with conventionally (succinimidyl ester) conjugated sdAb. + + + + 30773887 + + + + + + + + 2019 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 20 + 10 + 19 + 0 + + + + + + + 18 + We demonstrate that the epidermal growth factor receptor (EGFR) is required as a cofactor for Wnt9a-Fzd9b signalling. EGFR-mediated phosphorylation of one tyrosine residue on the Fzd9b intracellular tail in response to Wnt9a promotes internalization of the Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction + + + + 31110287 + + + + + + + + 2019 + 7 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 13 + 12 + 35 + 0 + + + + + + + 18 + In this study, using the antioxidant N-acetylcysteine (NAC), the authors show that hypoxia-induced reactive oxygen species in MDA-MB-468 breast cancer cells, selectively regulate hypoxia-induced increases in N-cadherin and SERPINE1, two proteins involved in cell adhesion. Treatment of cells with NAC also attenuated hypoxia-mediated activation of EGFR, but did not have any effect on hypoxia-mediated induction of HIF1alpha. + + + + 29123322 + + + + + + + + 2019 + 7 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 13 + 12 + 33 + 0 + + + + + + + 18 + EGFR may be a potential prognostic biomarker and novel therapeutic target for Clear cell renal cell carcinoma, especially patients with metastasis. + + + + 30895194 + + + + + + + + 2019 + 7 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 13 + 11 + 1 + 0 + + + + + + + 18 + Patients with advanced lung adenocarcinoma who had deletion in exon 19 (Ex19) of EGFR had shorter recurrence-free survival than those with L858R mutation in exon 21 (Ex21). + + + + 29486179 + + + + + + + + 2019 + 7 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 13 + 10 + 59 + 0 + + + + + + + 18 + Our study revealed the association between EGFR and resistance to a broad range of clinical drugs. EGFR is not only a factor in carcinogenesis, but probably also plays an essential role in development of drug resistance. + + + + 31262883 + + + + + + + + 2019 + 7 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 13 + 10 + 51 + 0 + + + + + + + 18 + Compared with common EGFR mutation, uncommon EGFR mutations in patients with nonsmall-cell lung cancer were associated with a modest sensitivity to EGFR tyrosine kinase inhibitors + + + + 30311393 + + + + + + + + 2019 + 7 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 6 + 11 + 14 + 0 + + + + + + + 18 + The A allele in rs2159359 SNP in NME1 and the G allele in rs13222385 in EGFR were associated with worse overall survival in endometrial cancer. Both exhibited genome wide significance; rs13222385 remained significant after adjusting for prognostic clinical variables. + + + + 30827726 + + + + + + + + 2019 + 7 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 6 + 11 + 2 + 0 + + + + + + + 18 + The natural history of EGFR mutant. + + + + 28534390 + + + + + + + + 2019 + 7 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 6 + 10 + 51 + 0 + + + + + + + 18 + Detection of the gene status of EGFR, ROS1, and MET will facilitate screening more NSCL adenocarcinoma patients who might benefit from targeted therapy. + + + + 28952227 + + + + + + + + 2019 + 7 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 6 + 10 + 30 + 0 + + + + + + + 18 + Silencing Rubcn, preventing EGFR activity or directly inducing autophagy in retinal pigment epithelial cells by starvation inhibits phagocytic degradation of photoreceptor outer segments. + + + + 28933590 + + + + + + + + 2019 + 7 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 7 + 6 + 10 + 13 + 0 + + + + + + + 18 + Knockdown of YB1 expression in different colon cancer cell lines decreased cell proliferation and migration regardless of the status of RAS/RAF. In contrast, YB1 knockdown altered the expression of apoptosisrelated genes and the expression of EGFR was detected in the cell lines expressing wildtype RAS/RAF but not in those expressing mutated RAS/RAF. + + + + 30864697 + + + + + + + + 2019 + 6 + 29 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 29 + 13 + 17 + 0 + + + + + + + 18 + this study shows a high concordance rate between EGFR mutations identified using primary tumor tissue and corresponding pleural effusion samples in non-small cell lung cancer + + + + 28800007 + + + + + + + + 2019 + 6 + 29 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 29 + 11 + 21 + 0 + + + + + + + 18 + NIH3T3 transfected with EGFR-PPARGC1A as well as A431 showed increased cell proliferation activity. With regard to underlying mechanism, EGFR-PPARGC1A protein causes constitutive tyrosine phosphorylation, and induces the phosphorylation of wild-type full-length epidermal growth factor receptor (EGFR) by dimerization. + + + + 28978917 + + + + + + + + 2019 + 6 + 29 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 29 + 10 + 34 + 0 + + + + + + + 18 + EGFR amplification had associated with poor prognosis in early, well to moderately differentiated carcinoma + + + + 27753660 + + + + + + + + 2019 + 6 + 29 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 29 + 10 + 34 + 0 + + + + + + + 18 + an increased EGFR gene copy number in surgically resected non-adenocarcinoma of non-small cell lung cancer was associated with worse survival + + + + 30017644 + + + + + + + + 2019 + 6 + 29 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 29 + 10 + 16 + 0 + + + + + + + 18 + Only modest improvement in response to HS-173 with reversible EGFR inhibitor gefitinib. + + + + 30858165 + + + + + + + + 2019 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 22 + 15 + 0 + 0 + + + + + + + 18 + only tumors expressing both EGFR and c-Fos responded to anti-EGFR therapy + + + + 30361264 + + + + + + + + 2019 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 22 + 11 + 50 + 0 + + + + + + + 18 + This is the first study to demonstrate the expression of EGFR protein in CTCs from sarcoma patients. + + + + 29394136 + + + + + + + + 2019 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 22 + 11 + 35 + 0 + + + + + + + 18 + These results suggest that a phosphorylated EGFR dimer loaded with core signaling adapters is not sufficient to activate Ras. + + + + 29514089 + + + + + + + + 2019 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 22 + 11 + 2 + 0 + + + + + + + 18 + Our analysis demonstrates that EGFR-TKIs confer significant PFS and OS benefits in the real-world practice for Korean female with advanced lung cancer + + + + 30905312 + + + + + + + + 2019 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 22 + 10 + 11 + 0 + + + + + + + 18 + This meta-analysis suggests that EGFR mutation can be a risk factor for brain metastases in non-small cell lung cancer + + + + 30761450 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 12 + 27 + 0 + + + + + + + 18 + Findings show that EGFR-TKI treatment facilitates gene resistant-mutation and the emergence of EGFR T790M secondary mutation by the attenuation of BER via induction of HSP70 protein degradation in non-small cell lung cancer. + + + + 29524558 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 12 + 16 + 0 + + + + + + + 18 + Results show that EGFR expression is regulated by Circ-ATP8A2 through sponging miR-433 in cervical cancer. + + + + 31029604 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 11 + 2 + 0 + + + + + + + 18 + Results show high expression level of EGFR protein in myeloma tissues from relapsed patients. + + + + 30611716 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 10 + 36 + 0 + + + + + + + 18 + this study not only advances our understanding of how IL-36 cytokines may control mucosal inflammation, but also establishes EGFR signaling as a potentially important modulator of IL-36 cytokine function + + + + 29474749 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 10 + 17 + 0 + + + + + + + 18 + Findings demonstrate that hypoxia-induced arginase II expression and cellular proliferation depend on autocrine epidermal growth factor production leading to epidermal growth factor receptor activation in human pulmonary microvascular endothelial cells. + + + + 29845760 + + + + + + + + 2019 + 6 + 15 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 15 + 10 + 17 + 0 + + + + + + + 18 + A phase II trial was conducted to assess the efficacy and safety of gefitinib plus bevacizumab for EGFR mutation-positive non-small cell lung cancer + + + + 30804129 + + + + + + + + 2019 + 6 + 8 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 8 + 12 + 42 + 0 + + + + + + + 18 + Study in human buccal epithelial squamous cell carcinoma cell line and murine oropharyngeal candidiasis model identify EGFR as a promoter of protective responses during C. albicans infection and highlight candidalysin and EGFR signalling components as potential targets for therapeutic intervention against mucosal candidiasis. + + + + 31127085 + + + + + + + + 2019 + 6 + 8 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 8 + 12 + 2 + 0 + + + + + + + 18 + The diagnostic performance of PANAMutypertrade mark was superior to that of PNAClamptrade mark for the detection of EGFR mutations. It was also better at identifying lung cancer patients with malignant pleural effusion who were likely to benefit from EGFR-TKI treatment. + + + + 30804147 + + + + + + + + 2019 + 6 + 8 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 8 + 11 + 53 + 0 + + + + + + + 18 + EGFR exon 20 mutations characterize those inverted sinonasal papillomas with a lower risk of developing into squamous cell carcinoma. + + + + 30411788 + + + + + + + + 2019 + 6 + 8 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 8 + 11 + 52 + 0 + + + + + + + 18 + analyze the allosteric and ATP-competitive inhibitors in terms of drug discovery, binding mechanism, and their potency and selectivity against EGFR harboring C797S mutations + + + + 29136465 + + + + + + + + 2019 + 6 + 8 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 8 + 11 + 49 + 0 + + + + + + + 18 + whole exome-sequencing (WES) revealed a novel activating EGFR mutation-I645L, mediating resistance to the bromodomain and extra-terminal domain (BET) inhibitor, JQ1 r + + + + 30770740 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 13 + 3 + 0 + + + + + + + 18 + the novel benzo[4,5]imidazo[2,1-b]thiazole derivatives as novel potential EGFR inhibitors may be used as the potential lead compounds for the development of antitumor agents. + + + + 30769844 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 13 + 3 + 0 + + + + + + + 18 + CuB could suppress the growth and invasion of GR NSCLC cells by inducing the lysosomal degradation of EGFR. + + + + 30759826 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 13 + 3 + 0 + + + + + + + 18 + Genotype at rs11977660 was significantly associated with endometriosis (P < .05 for genotype and allele). T/T+C/T genotypes were associated with significantly higher risk of developing endometriosis than the C/C genotype (OR 2.129, 95%CI 1.411-3.212). No significant association was found between genotype at rs2072454 and endometriosis. + + + + 31027056 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 11 + 35 + 0 + + + + + + + 18 + The conformational coupling across multiple EGFR domains results in growth factor-specific information transfer, and demonstrate that this model applies to both EGFR and the related receptor ErbB2. + + + + 29731426 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 11 + 18 + 0 + + + + + + + 18 + EGFR inhibitors display limited therapeutic efficacy in Glioblastoma multiforme (GBM) patients, the EGFRvIII-Stat5-Fn14 signaling pathway represents a node of vulnerability in the invasive GBM cell populations.Implications: Targeting critical effectors in the EGFRvIII-Stat5-Fn14 pathway may limit GBM tumor dispersion, mitigate therapeutic resistance, and increase survival. + + + + 29724813 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 11 + 10 + 0 + + + + + + + 18 + LINC00520-targeted EGFR inhibition might result in the inactivation of the PI3K/Akt pathway, thus inhibiting cutaneous squamous cell carcinoma (cSCC) development. + + + + 30707166 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 10 + 22 + 0 + + + + + + + 18 + EGFR T790M is associated with acquired resistance to afatinib in patients with advanced lung adenocarcinoma but with somewhat lower frequency. The influence of EGFR C797S on resistance to afatinib is less than that of T790M, but C797S might cause shorter progression free survival under osimertinib. + + + + 30550608 + + + + + + + + 2019 + 6 + 1 + 10 + 2 + 0 + + + + + + + + + 2019 + 6 + 1 + 10 + 14 + 0 + + + + + + + 18 + over-expression of DIRAS3 promotes EGFR-AKT signaling activation at the downstream of EGFR and increases AKT phosphorylation + + + + 30266404 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 12 + 38 + 0 + + + + + + + 18 + A statistically positive correlation of p-EGFR(Y1068) expression with IFIT1 and IFIT3 in OSCC tumors. + + + + 30626937 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 12 + 6 + 0 + + + + + + + 18 + Cx32 expression may induce cisplatin resistance by modulating drug efflux transporter expression and activating the EGFRprotein kinase B signalling pathway in ovarian cancer cells. + + + + 30664215 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 12 + 4 + 0 + + + + + + + 18 + The LRIG1 triggers EGFR degradation and that mutated EGFR induces beta-catenin activity. + + + + 30314701 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 11 + 59 + 0 + + + + + + + 18 + Treatment with lapatinib reduced BeWo cell proliferation by inducing apoptosis. Moreover, AREG treatment stimulated BeWo cell proliferation by activating ERK1/2 and PI3K/AKT signaling pathways, which was blocked by lapatinib. Targeting EGFR/HER2 might be a useful therapeutic strategy for human choriocarcinoma + + + + 31092430 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 11 + 1 + 0 + + + + + + + 18 + The incidence of both EGFR and ALK1 mutations is higher in the adenocarcinoma of the lung population studied and seem to correlate with a well differentiated, acinar pattern on morphology. + + + + 30706855 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 10 + 56 + 0 + + + + + + + 18 + EGFR expression is regulated by oncogenic HPV16 E6 protein in ovarian cancer.KDM5C regulates cervical cancer cell EGFR expression by modulating their super-enhancer H3K4 methylation dynamics + + + + 29339538 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 10 + 44 + 0 + + + + + + + 18 + This study suggests that there is no difference on survival between lung adenocarcinoma patients with EGFR mutations and those without, but the patients harboring EGFR 19del mutation have survival advantage compared to those harboring EGFR L858R mutation. + + + + 30022385 + + + + + + + + 2019 + 5 + 25 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 25 + 10 + 16 + 0 + + + + + + + 18 + Study indicated that EGFR and PKM2 directly interact and bind with each other to regulate the transcription of stemness-related genes and promote the stem-like phenotype, thus promoting invasion and metastasis of lung neoplasm. + + + + 29477380 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 12 + 21 + 0 + + + + + + + 18 + Mechanistically, the rs884225 C allele enhanced EGFR expression by altering the miR-103a-3p binding site, thus impairing miR-103a-3p's anti-tumourigenic function. As a tumour suppressor gene, miR-103a-3p expression correlated with overall and recurrence-free survival in Non small cell lung carcinoma patients. rs884225 may be a biomarker for NSCLC susceptibility, and miR-103a-3p may be a potential therapeutic target. + + + + 30470824 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 12 + 20 + 0 + + + + + + + 18 + Results indicate that lung neoplasms patients carrying EGFR mutations are prone to multiple metastases in both lungs. + + + + 29454587 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 12 + 17 + 0 + + + + + + + 18 + the cells with activating mutants of EGFR inactivate Mig6 through phosphorylation at S256. + + + + 29196224 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 12 + 6 + 0 + + + + + + + 18 + exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms + + + + 29976202 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 11 + 29 + 0 + + + + + + + 18 + EGFR mutation is related to low metabolic activity of localized lung adenocarcinoma at FDG PET/CT. Because of differences in the metabolic activity of EGFR mutant and wild-type tumors, EGFR mutation status must be considered when FDG PET/CT parameters are used for prognosis. + + + + 29547059 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 11 + 24 + 0 + + + + + + + 18 + EGFR-mediated beta-catenin nuclear accumulation is critical for Akt1 inhibition-induced breast cancer metastasis + + + + 30445978 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 10 + 44 + 0 + + + + + + + 18 + EGFR Mutations are associated with Lung Cancer. + + + + 30677862 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 10 + 30 + 0 + + + + + + + 18 + USP17 facilitates trafficking and oncogenic signaling of mutant EGFR + + + + 30409180 + + + + + + + + 2019 + 5 + 18 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 18 + 10 + 4 + 0 + + + + + + + 18 + These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERalpha(+) breast cancers + + + + 29720215 + + + + + + + + 2019 + 5 + 11 + 10 + 3 + 0 + + + + + + + + + 2019 + 5 + 11 + 13 + 19 + 0 + + + + + + + 18 + TEM8 is a novel receptor for uPA + + + + 30241478 + + + + + + + + 2019 + 5 + 11 + 10 + 3 + 0 + + + + + + + + + 2019 + 5 + 11 + 12 + 42 + 0 + + + + + + + 18 + Results show that the few EGFRs isolated in membrane subdomains were released by an EGF-dependent increase in their diffusion area, facilitating molecular associations and producing immobile clusters. A two-color single-molecule analysis found that the EGF-induced state transition alters the properties of the immobile clusters, allowing them to interact for extended periods with the cytoplasmic protein, GRB2. + + + + 29505756 + + + + + + + + 2019 + 5 + 11 + 10 + 3 + 0 + + + + + + + + + 2019 + 5 + 11 + 11 + 8 + 0 + + + + + + + 18 + Promotion of EGFR signaling is a critical function of beta-catenin during hepatocellular carcinoma progression. + + + + 31015417 + + + + + + + + 2019 + 5 + 11 + 10 + 3 + 0 + + + + + + + + + 2019 + 5 + 11 + 10 + 56 + 0 + + + + + + + 18 + Decreased cell proliferation was further supported by the down-regulation of p-EGFR. + + + + 30678455 + + + + + + + + 2019 + 5 + 11 + 10 + 3 + 0 + + + + + + + + + 2019 + 5 + 11 + 10 + 46 + 0 + + + + + + + 18 + in mammary cells, EGF receptor, the activity of which is potentiated by reactive oxygen species and inhibited by hypoxia, represents the molecular target that guides hypoxic cells to oxygen. + + + + 30382089 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 12 + 38 + 0 + + + + + + + 18 + EGFR mutations were discovered in 32.9 % of patients with non-small-cell lung and overall rate of consistency for the paired plasma and tissue samples was 86.1 % . Of 21 patients with EGFR sensitive mutation defined by next generation sequencing in ctDNA, 20 showed long-term disease control with epidermal growth factor receptor tyrosine kinase inhibitor treatment; the median progression-free survival was 10.8 months. + + + + 30787028 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 12 + 34 + 0 + + + + + + + 18 + The results identify a novel mechanism of TRAF4-mediated EGFR activation and signaling. + + + + 30352854 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 12 + 34 + 0 + + + + + + + 18 + Despite both ligands binding to the EGFR, BTC biases the EGFR to dimerize with ErbB3 to regulate the biologic response. + + + + 30249613 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 11 + 34 + 0 + + + + + + + 18 + Importantly, in the absence of EGFR genetic alterations, miR-205/ERRFI1-driven EGFR activation rendered MET- tyrosine kinase inhibitor-resistant cells sensitive to combined MET/EGFR inhibition. + + + + 30021798 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 10 + 28 + 0 + + + + + + + 18 + Female patients contributed to about 28% of all NSCLC cases. They were mostly non-smokers, have more adenocarcinoma histopathology and eGFR mutation. Survival tended to be longer in female than male patients. Age over 50 years and the presence of eGFR mutation were good prognostic factors to survival in female lung cancer patients. + + + + 30630993 + + + + + + + + 2019 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2019 + 5 + 4 + 10 + 13 + 0 + + + + + + + 18 + EpEX is a ligand of EGFR that induces proliferation but counteracts epithelial-mesenchymal transition mediated by the EGF/EGFR/pERK1/2 axis. + + + + 30261040 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 11 + 58 + 0 + + + + + + + 18 + Authors perform a systems analysis of a model of EGFR-mutated nonsmall cell lung cancer resistant to targeted therapy that integrates whole exome sequencing, global time-course discovery phosphoproteomics and computational modeling to identify functionally relevant molecular alterations. + + + + 30183078 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 11 + 57 + 0 + + + + + + + 18 + Treatment of PANC1 cells with degalactotigonin induced cell cycle arrest at G0/G1 phase. Compound 1 induced downregulation of cyclin D1 and upregulation of p21 in a time- and concentration-dependent manner and inhibited EGF-induced phosphorylation of EGFR, as well as activation of EGFR downstream signaling molecules such as Akt and ERK. + + + + 30643798 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 11 + 40 + 0 + + + + + + + 18 + High levels of EGFR and its downstream effector FAK are associated with the progression of papillary thyroid carcinoma. + + + + 29665129 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 11 + 4 + 0 + + + + + + + 18 + Study describes multiple configurations of EGFR T790M and third-generation EGFR tyrosine kinase inhibitors (TKIs) resistance mutations at codons 792, 796, and 797 in non-small cell lung cancer. These mutations are most commonly found in cis, which confers resistance to all current EGFR TKIs. Also describe two patients that exhibited T790M loss with acquisition of a mutation at codon 797. + + + + 30481207 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 10 + 55 + 0 + + + + + + + 18 + This study demonstrated the significance of hscFv as a potential immunotherapeutic agent as well as a targeting agent for specific delivery of drugs to EGFRvIII expressing cancer cells. + + + + 30471391 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 10 + 55 + 0 + + + + + + + 18 + BRCA1 losses correlated to higher T stage (p = 0.027), Gleason score (p = 0.039), shorter time to biochemical recurrence in patients with Gleason score > 7 independently of other factors (multivariate analysis, p = 0.005) as well as expression of proteins regulating stemness and epithelial-mesenchymal transition, that is, ALDH1 (p = 0.021) and EGFR (p = 0.011), respectively. + + + + 30265376 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 10 + 13 + 0 + + + + + + + 18 + ANXA1 acts as a tumour suppressor in head and neck squamous cell carcinoma, regulating EGFR activity and exosomal phospho-EGFR release. + + + + 30142511 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 10 + 13 + 0 + + + + + + + 18 + EGFR and KRAS mutation status was associated with the expression of AKT, p-AKT, DR5, and DcR1 in non-small cell lung cancer + + + + 28043144 + + + + + + + + 2019 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 27 + 10 + 3 + 0 + + + + + + + 18 + miR-646 is a key negative regulator of EGFR pathway in lung cancer. + + + + 27462913 + + + + + + + + 2017 + 12 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 22 + 10 + 22 + 0 + + + + + + + 18 + Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors through inhibition of STAT3. Taken together, the results indicate that rhein offers a novel blueprint for pancreatic cancer therapy, particularly when combined with EGFR inhibitors + + + + 30674340 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 12 + 22 + 0 + + + + + + + 18 + UCA1 directly interacted with miR-7-5p and decreased the binding of miR-7-5p to the EGFR 3'-untranslated region, which suppressed the degradation of EGFR mRNA by miR-7-5p. + + + + 29723509 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 11 + 40 + 0 + + + + + + + 18 + This study screened out patients with EGFR exon19 mutation who had a better response to EGFR-tyrosine kinase inhibitors , which contributes to guiding the clinical treatment of advanced non-small cell lung adenocarcinoma. + + + + 30383772 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 11 + 33 + 0 + + + + + + + 18 + The study confirmed the prognostic value of poor overall survival and progression free survival of TP53 commutation in EGFR mutant lung cancers. + + + + 30798634 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 11 + 23 + 0 + + + + + + + 18 + For Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and brain metastases, erlotinib was associated with a significantly longer overall survival and a more prolonged progression-free survival, compared with gefitinib. + + + + 30458751 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 10 + 58 + 0 + + + + + + + 18 + The obtained results reveal that the activation of the MAPK-ERK1/2 and -p38 pathways by the magnetic field is mediated by the EGF receptor. + + + + 30964607 + + + + + + + + 2019 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 20 + 10 + 49 + 0 + + + + + + + 18 + the EGFR mutation in lobular breast carcinoma + + + + 29139619 + + + + + + + + 2019 + 4 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 13 + 12 + 18 + 0 + + + + + + + 18 + In this review, we will summarize current knowledge of the EGFR nuclear signaling network, including how it is delivered to the nucleus, the functions it serves in the nucleus and how these functions affect cancer progression, survival and the response to treatment. [review] + + + + 30362453 + + + + + + + + 2019 + 4 + 13 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 13 + 11 + 18 + 0 + + + + + + + 18 + we found that RBM10 activated key proliferative signaling pathways [such as the epidermal growth factor receptor (EGFR), mitogenactivated protein kinase (MAPK) and phosphoinositide 3kinase (PI3K)AKT pathways] and inhibited apoptotic pathways. In addition, we demonstrated that a high expression of RBM10 protein in patient tissue samples was associated with a shorter overall survival time and a poor prognosis + + + + 30483773 + + + + + + + + 2019 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 6 + 12 + 47 + 0 + + + + + + + 18 + we recommend that anti-EGFR anchored PTX loaded NP may have the ability to target the triple negative breast cancer( TNBC) cells and improve the therapeutic action and subsidize the side effects of PTX for the treatment of TNBC + + + + 30408068 + + + + + + + + 2019 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2019 + 4 + 6 + 12 + 39 + 0 + + + + + + + 18 + Measurements of circulating DNA within body fluids presented potentially new tools for the disease management of Non-Small-Cell Lung Carcinoma (NSCLC) patients with EGFR mutations. We demonstrated both plasma and urinal DNA correlated well to tissue biopsies and were potentially prognostic to address patients' survival outcome. + + + + 30223392 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 13 + 8 + 0 + + + + + + + 18 + Data show that epidermal growth factor receptor (EGFR) expression positively correlated with the grade of tissue degeneration. + + + + 28819180 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 12 + 23 + 0 + + + + + + + 18 + Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling + + + + 27475257 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 12 + 23 + 0 + + + + + + + 18 + Rescue of HPV16 E6/E7 expression with simultaneous HPV16 E5 knockdown confirmed that E5 plays a key role in EGFR overexpression and EGFR-induced viral invasion. + + + + 29624161 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 12 + 3 + 0 + + + + + + + 18 + These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation. + + + + 30089695 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 12 + 2 + 0 + + + + + + + 18 + Adenocarcinoma component harboring the EGFR mutation became dominant in association with disease progression. + + + + 29546681 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 11 + 10 + 0 + + + + + + + 18 + A dual specificity phosphatase, DUSP6, that negatively regulates phosphorylation of (P)-ERK is up-regulated in EGFR- or KRAS-mutant lung adenocarcinoma (LUAD), potentially protecting cells with mutations in the RAS signaling pathway, a proposal supported by experiments with DUSP6-specific siRNA and an inhibitory drug + + + + 30475204 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 57 + 0 + + + + + + + 18 + For non-squamous NSCLC patients harboring activating EGFR mutations. + + + + 29101518 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 53 + 0 + + + + + + + 18 + Results show that the rs9642391C>G variant, which is located in the intron region of EGFR, is associated with GBAS expression and survival outcomes in surgically resected early-stage non-small cell lung cancer patients. + + + + 29806744 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 48 + 0 + + + + + + + 18 + Dual EGFR/HER2 knockdown by siRNAs further decreased the growth of Gastric Cancer cells treated with gefitinib alone, confirming that single-agent drug targeting does not achieve a maximal biological effect. + + + + 29637613 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 21 + 0 + + + + + + + 18 + Lung adenocarcinoma patients with EGFR-tyrosine kinase inhibitor sensitizing mutations, have a lower mutational burden and do not show a characteristic mutation pattern influenced by smoking. + + + + 30522449 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 5 + 0 + + + + + + + 18 + low levels of HIF-1alpha mRNA or EGFR mRNA are negative independent prognostic markers for soft tissue sarcoma patients, especially after combination of both parameters. + + + + 30513863 + + + + + + + + 2019 + 3 + 30 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 30 + 10 + 5 + 0 + + + + + + + 18 + The promising predictive biomarkers for emerging refractory tumors with the EGFR-T790M mutation. + + + + 30537950 + + + + + + + + 2019 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 23 + 12 + 19 + 0 + + + + + + + 18 + May be clinically beneficial for patients with EGFR mutation-positive lung adenocarcinoma. + + + + 30536070 + + + + + + + + 2019 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 23 + 12 + 19 + 0 + + + + + + + 18 + RNF144A promotes EGFR ubiquitination, maintains EGFR protein, and prolongs EGF/EGFR signaling during EGF stimulation. + + + + 30171075 + + + + + + + + 2019 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 23 + 12 + 10 + 0 + + + + + + + 18 + Studies found EGFR C797S mutation was the major resistance mechanism to EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer patients with original EGFR T790M mutation. [review] + + + + 29425688 + + + + + + + + 2019 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 23 + 11 + 12 + 0 + + + + + + + 18 + EGFR mutation is associated with good response to chemotherapy in Lung Adenocarcinoma. + + + + 29628320 + + + + + + + + 2019 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 23 + 10 + 54 + 0 + + + + + + + 18 + FHL2 interacts with EGFR and EGFRvIII to increase their levels and this promotes glioma growth, representing a novel mechanism that may be therapeutically targetable. + + + + 29321665 + + + + + + + + 2019 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 16 + 13 + 11 + 0 + + + + + + + 18 + Results show that nicotine induced the phosphorylation of EGFR through nAChR in head and neck squamous cell carcinoma (HNSCC). Phosphorylated EGFR was translocated from the cell surface to the nucleus, and activated Akt and mTOR. These signaling pathways elevated the cell activities of HNSCC cells, causing lymph node metastasis and resistance to cetuximab. + + + + 30431077 + + + + + + + + 2019 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 16 + 11 + 6 + 0 + + + + + + + 18 + Exon 21 EGFR Mutation is associated with Stage III in Non-small Cell Lung Cancer Adenocarcinoma. + + + + 29362963 + + + + + + + + 2019 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 16 + 10 + 30 + 0 + + + + + + + 18 + No difference in EGFR expression observed among colorectal tumors from Greek patient population. + + + + 29552755 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 36 + 0 + + + + + + + 18 + Lentivirus mediated ADAM17 RNAi may reverse the acquired resistance of lung adenocarcinoma to gefitinib via inhibiting the upstream of EGFR signal pathway, which may provide a new therapeutic target to solve the acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma + + + + 28960861 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 34 + 0 + + + + + + + 18 + Associations have been identified between radiological features and clinical features with Epidermal Growth Factor Receptor (EGFR)/ Kirsten RAt Sarcoma (KRAS) alterations in an independent group of patients with Non-Small Cell Lung Cancer (NSCLC). + + + + 30599853 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 34 + 0 + + + + + + + 18 + The apoptosis of NSCLC through the PI3K/AKT pathway by EGFR. + + + + 30747217 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 25 + 0 + + + + + + + 18 + The molecular mechanism behind EGFR-mutant patients showing unfavorable responses to immune checkpoint inhibitors. + + + + 30582659 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 19 + 0 + + + + + + + 18 + Females were often inflicted by the EGFR mutations, especially for the exon 19 deletion and L858R mutation. There were significantly more ALK/ROS1 fusions in females compared to that in males and significantly more ALK/ROS1 fusions in patients <60 years old compared to patients older than 60 years of age. Exon 21 L858R and L861Q dominantly occurred in patients >/=60 years and exon 19 deletion in patients <60 years + + + + 30580372 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 12 + 19 + 0 + + + + + + + 18 + Acquired drug resistance may limit the therapeutic potential of EGFR-TKIs. + + + + 29785875 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 11 + 43 + 0 + + + + + + + 18 + High EGFR expression is associated with angiogenesis in B16 melanoma. + + + + 29483644 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 11 + 29 + 0 + + + + + + + 18 + There is heterogeneity of EGFR mutation in lung adenocarcinoma. The presence of lung adenocarcinoma with acinar indicates a higher EGFR mutation rate, while the solid and mucinous component indicates a lower EGFR mutation rate. + + + + 30122764 + + + + + + + + 2019 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 9 + 10 + 41 + 0 + + + + + + + 18 + Synchronous brain metastasis was more common in NSCLC patients with EGFR mutation than in those with EGFR wild type. However, EGFR mutations were associated with significantly longer median brain metastasis overall survival, especially when the brain was the first metastatic site. + + + + 27093978 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 12 + 34 + 0 + + + + + + + 18 + EGFR overexpression is associated with disease recurrence following adjuvant chemotherapy for advanced bladder cancer. + + + + 30413194 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 12 + 25 + 0 + + + + + + + 18 + Our results indicate that administration of U3-1402 alone or in combination with an EGFR-TKI may have potential as a novel therapy for EGFR-TKI-resistant EGFR-mutant non-small cell lung cancer (NSCLC) + + + + 30302022 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 12 + 23 + 0 + + + + + + + 18 + Results show that EGFR domains I and III bind to ANG regulating its signaling pathway in an autocrine or paracrine manner which in turn promotes pancreatic tumorigenesis. + + + + 29606349 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 12 + 8 + 0 + + + + + + + 18 + Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings + + + + 29203120 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 11 + 4 + 0 + + + + + + + 18 + Targeting EGFR ligands may benefit patients who carry EGFR-mutant lung tumors but will not benefit patients with KRAS-mutant lung tumors. + + + + 29662194 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 57 + 0 + + + + + + + 18 + Additional protein interaction characterization revealed epidermal growth factor receptor (EGFR) as a novel interacting partner for RANK-c in breast cancer cells. + + + + 29844572 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 52 + 0 + + + + + + + 18 + These studies establish TWIST1 as a driver of resistance to EGFR TKIs and provide rationale for use of TWIST1 inhibitors or BCL2 inhibitors as means to overcome EMT-mediated resistance to EGFR TKIs. + + + + 30171258 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 50 + 0 + + + + + + + 18 + While a significant correlation between the two methods is shown. ddPCR is more sensitive than Super-ARMS in the detection of EGFR T790M mutation, indicating that it is a better method in guiding target drug therapy of non-small cell lung cancer patients after acquiring the resistance to EGFR-TKI. + + + + 30522170 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 50 + 0 + + + + + + + 18 + Aldolase A (ALDOA) knockdown reduced cyclin D1 expression by regulating epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) pathway. + + + + 29764507 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 42 + 0 + + + + + + + 18 + A critical role for APE1 induction in activating the EGFR-STAT3 signaling axis. + + + + 29991802 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 34 + 0 + + + + + + + 18 + To achieve this, using semi-quantitative mass spectrometry, we found MUC1 to be significantly and durably upregulated in response to erlotinib, an EGFR-targeting treatment. MUC1 upregulation was regulated transcriptionally, involving PI3K-signaling and STAT3 + + + + 30305724 + + + + + + + + 2019 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 3 + 2 + 10 + 12 + 0 + + + + + + + 18 + Inhibition of aurora kinases preferentially kills mutant KRAS CRC cells and overcomes KRAS-mediated resistance to anti-EGFR antibodies in vitro and in vivo by restoring PUMA induction. + + + + 29755130 + + + + + + + + 2019 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 23 + 13 + 3 + 0 + + + + + + + 18 + TGF-beta promotes the migration and invasion abilities of breast cancer cells, along with the increase in EGFR expression. + + + + 29215776 + + + + + + + + 2019 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 23 + 12 + 59 + 0 + + + + + + + 18 + MiR-483-3p as a promising target for combination therapy to overcome acquired EGFR TKI resistance in EGFR-mutant NSCLC. + + + + 29717264 + + + + + + + + 2019 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 23 + 12 + 57 + 0 + + + + + + + 18 + we illustrate how abnormal trafficking of EGFR oncogenic mutants, as well as alterations of the endocytic machinery, contributes to aberrant EGFR signaling in cancer. + + + + 30097778 + + + + + + + + 2019 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 23 + 11 + 2 + 0 + + + + + + + 18 + Study demonstrated that EGFR activation could upregulate the BLIMP1 gene transcription via the PKC, p38, and ERK pathways in keratinocytes. Besides, proteasome and lysosome contribute to the maintenance of BLIMP1 protein stability. + + + + 30197274 + + + + + + + + 2019 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 23 + 10 + 48 + 0 + + + + + + + 18 + the wild-type subgroup refers to EGFR negative/ALK negative, EGFR negative/ALK unknown, and EGFR unknown/ALK negative populations. Wild type and unknown subgroups were defined as EGFR negative/ALK negative, EGFR negative/ALK unknown, EGFR unknown/ALK negative, and EGFR unknown/ALK unknown populations. Adverse events (AEs) were recorded according to Common Terminology Criteria for Adverse Events version 4.0. + + + + 29768721 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 12 + 31 + 0 + + + + + + + 18 + The total EGFR mutation rate in the early-stage group was similar to that in the advanced-stage group (53.6% vs. 51.4%, respectively; P = 0.379). There was no significant difference in EGFR mutation type between the two groups. In subgroup analysis of smoking history, there was no difference in EGFR mutation frequency or type between the early-stage and advanced-stage groups. + + + + 29722148 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 12 + 24 + 0 + + + + + + + 18 + EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression. + + + + 29558202 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 12 + 2 + 0 + + + + + + + 18 + The mechanism of primary resistance to osimertinib remains unclear. There may be an association between T790 M mutation disappearance, TP53 mutation and radiotherapy, but further researches are needed to confirm this + + + + 30400855 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 11 + 2 + 0 + + + + + + + 18 + Re-biopsy in advanced non-small cell lung cancer is feasible in real world clinical practice, particularly in younger patients and those who achieved a previous response to EGFR-tyrosine kinase inhibitor (TKI). + + + + 29761660 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 10 + 45 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) is identified as a direct target gene of miR-769-5p. + + + + 30601026 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 10 + 39 + 0 + + + + + + + 18 + High EGFR expression is associated with prostate cancer. + + + + 29794138 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 10 + 34 + 0 + + + + + + + 18 + EGFR tyrosine kinase inhibitors had modest efficacy in lung adenosquamous carcinoma, especially in patients with EGFR mutation. Based on the pathological features, EGFR mutation and EGFR tyrosine kinase inhibitors treatment should be introduced into the routine clinical practice to improve the survival of patients with lung adenosquamous carcinoma. + + + + 30392343 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 10 + 24 + 0 + + + + + + + 18 + This study unravels an anti-metastatic role of AKT1 in the NSCLC cells with KRAS or EGFR mutations, and establishes an AKT1-MARCKS-LAMC2 feedback loop in this regulation. + + + + 28765579 + + + + + + + + 2019 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 16 + 10 + 13 + 0 + + + + + + + 18 + In order to develop appropriate QSAR model for identification of EGFR mutant inhibitor we identified that amino-pyrimidine derivatives are the most potent inhibitors and therefore, we have undertaken a study to develop 2 D and 3 D QSAR models for series of amino-pyrimidine derivatives with their known TMLR activity + + + + 30204041 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 12 + 50 + 0 + + + + + + + 18 + during this pilot study we applied a high-sensitivity protocol for detection of tumor-derived mutations in circulating plasma DNA of EGFR-positive non-small cell lung cancer (NSCLC) patients during EGFR-TKI therapy + + + + 30475540 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 11 + 4 + 0 + + + + + + + 18 + PD-L1 expression was significantly associated with wild-type EGFR, and PD-L1 TPS >/=50% seldom overlaps with presence of driver oncogene EGFR. There was no significant difference in PD-L1 expression among the EGFR mutation sites. + + + + 29413045 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 58 + 0 + + + + + + + 18 + EGFR inhibition can only sensitize EGFR-high cells for chemotherapy, while AKT inhibition increases chemosensitivity in EGFR-low cells. By understanding these mechanisms, we can take advantage of the cellular context to individualize antineoplastic therapy. Finally, our data also suggest targeting of EFFRI1 in EGFR-low cancer as a promising therapeutic approach + + + + 29335246 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 30 + 0 + + + + + + + 18 + EGFR-phosphorylated platelet isoform of phosphofructokinase 1 promotes PI3K activation, promoting the Warburg effect, tumor cell proliferation, and brain tumorigenesis. + + + + 29677490 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 30 + 0 + + + + + + + 18 + role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (Review) + + + + 30406002 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 27 + 0 + + + + + + + 18 + EGFR hotspot mutations, namely L858R mutation and exon 19 in-frame deletion, were reverse associated with E-cadherin gene polymorphisms in lung adenocarcinoma + + + + 30008585 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 20 + 0 + + + + + + + 18 + High EGFR expression is associated with Bladder Cancer. + + + + 29298735 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 13 + 0 + + + + + + + 18 + Mutated EGFR mediates tyrosine kinase inhibitor resistance through regulation of the fatty acid synthase (FASN), which produces 16-C saturated fatty acid palmitate. + + + + 29449326 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 13 + 0 + + + + + + + 18 + Pathway analysis suggested that EGFR signaling might be involved in primary open-angle glaucoma pathogenesis. + + + + 29452408 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 13 + 0 + + + + + + + 18 + Ligand-activated EGFR signaling controls unliganded receptors through feedback phosphorylation. + + + + 29255092 + + + + + + + + 2019 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 9 + 10 + 3 + 0 + + + + + + + 18 + LRIG1 exerts important tumor-suppressive effects in EGFR-mutant NSCLC. + + + + 29546323 + + + + + + + + 2019 + 2 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 2 + 12 + 5 + 0 + + + + + + + 18 + Study showed that a gain of EGFR gene copy number can be observed in 30% of the oral cavity squamous cell carcinoma (OSCC) tumors and this frequency was only slightly increased in tumors from individuals with the CA repeat genotype compared to those with the SS genotype. The EGFR CA repeat polymorphism may play a role synergistically with tumor EGFR expression level in predicting outcome among OSCC patients. + + + + 28694429 + + + + + + + + 2019 + 2 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 2 + 11 + 20 + 0 + + + + + + + 18 + these results suggest that sustained presence of lipid inflammatory mediator LTD4 could induce human airway epithelial cell proliferation through ERK1/2 phosphorylation, either directly via CysLT1 receptor or by transactivating EGFR. + + + + 29751150 + + + + + + + + 2019 + 2 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 2 + 10 + 47 + 0 + + + + + + + 18 + significant correlation between mutations in exon 19 (rs121913438) and exon 21(rs121434568) and susceptibility to uterine myoma + + + + 30149365 + + + + + + + + 2019 + 2 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 2 + 10 + 46 + 0 + + + + + + + 18 + Expression of phospho-EGFR and -Akt as well as the pro-inflammatory molecules TNF-alpha. + + + + 29982425 + + + + + + + + 2019 + 2 + 2 + 10 + 2 + 0 + + + + + + + + + 2019 + 2 + 2 + 10 + 33 + 0 + + + + + + + 18 + the results of the present study indicate that, in GBM cells, EGFRvIII is connected with the S1P signaling pathway to enhance cell invasiveness and tumor progression. + + + + 29427528 + + + + + + + + 2019 + 1 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 26 + 12 + 15 + 0 + + + + + + + 18 + In this study, we focused on patients with gastric cancer who received preoperative chemotherapy and aimed to examine the changes in HER2 expression status and amplification of EGFR and MET, not only after HER2-targeted therapy, but also after cytotoxic chemotherapy alone. + + + + 30348707 + + + + + + + + 2019 + 1 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 26 + 11 + 46 + 0 + + + + + + + 18 + Negative expression of HuR and Bim correlates with lower EGFR-tyrosine kinase inhibitors sensitivity in tumor tissues obtained from EGFR-mutant nonsmall cell lung cancer patients. + + + + 30226552 + + + + + + + + 2019 + 1 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 26 + 11 + 39 + 0 + + + + + + + 18 + Combined treatment with NNK and arecoline synergistically facilitated tumor aggressiveness via EGFR-AKT signaling. + + + + 30148841 + + + + + + + + 2019 + 1 + 26 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 26 + 10 + 29 + 0 + + + + + + + 18 + Co-expression of high levels of beta-catenin and EGFR in association with clinicopathological features implicates their clinical utility in risk stratification of PTC patients, and supports the possibility of crosstalk between Wnt/beta-catenin and EGFR signaling during PTC progression. + + + + 30077672 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 12 + 20 + 0 + + + + + + + 18 + High EGFR expression is associated with cholangiocarcinoma metastasis. + + + + 30359740 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 12 + 7 + 0 + + + + + + + 18 + Negative regulation of EGFR signalling by FLCN protein. + + + + 28656962 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 50 + 0 + + + + + + + 18 + Our findings also suggest that prostate cancer cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of prostate cancer patients. + + + + 30134822 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 48 + 0 + + + + + + + 18 + In breast cancer cells, HOXB5 regulates EGFR expression at the transcriptional level by directly binding to its promoter region and promotes phosphorylation of EGFR as well as its downstream effectors. + + + + 30115380 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 45 + 0 + + + + + + + 18 + MiR-630 may be a potential biomarker for the prediction of tyrosine kinase inhibitors therapeutic response and outcome in patients with lung adenocarcinoma. + + + + 29507618 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 35 + 0 + + + + + + + 18 + Data show that Y-box binding protein-1 (YBX1) promoted tumorigenesis and progression in spinal chordoma via the epidermal growth factor receptor (EGFR)/proto-oncogene proteins c-akt (AKT) pathway. + + + + 30426615 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 28 + 0 + + + + + + + 18 + High EGFR expression is associated with recurrence of basal cell carcinoma. + + + + 30419251 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 28 + 0 + + + + + + + 18 + Y845 phosphorylation induces a catalytically active conformation in EGFR monomers. This conformational transition depends on EGFR kinase activity and auto-phosphorylation on its C-terminal tail, generating a looped causality that leads to autocatalytic amplification of EGFR phosphorylation at low EGF dose. + + + + 30242154 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 11 + 14 + 0 + + + + + + + 18 + Studied impact of cumulative smoking dose (CSD) on clinical outcomes, including progression-free survival (PFS) and overall survival (OS), in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma receiving EGFR-tyrosine kinase inhibitors. Found CSD was inversely associated with PFS in a dose-dependent manner. + + + + 30055587 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 10 + 49 + 0 + + + + + + + 18 + Results suggest that mutational activation of epidermal growth factor receptor (EGFR) inhibits major histocompatibility complex class I (MHC-I) expression through the MEK-ERK pathway in non-small cell lung cancer (NSCLC). + + + + 30390416 + + + + + + + + 2019 + 1 + 19 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 19 + 10 + 37 + 0 + + + + + + + 18 + Patients with expression EGFR had significantly shorter PFS and OS compared with patients without EGFR expression. + + + + 26925790 + + + + + + + + 2019 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 12 + 12 + 6 + 0 + + + + + + + 18 + EGFR may be involved in immune evasion, possibly through regulation of B7H5 expression in nonsmall cell lung carcinoma. + + + + 30106102 + + + + + + + + 2019 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 12 + 12 + 4 + 0 + + + + + + + 18 + The highly specific targeted property of (188)Re-cetuximab suggested that it is suitable as a diagnostic tool and maybe a potent radioimmunotherapy agent in EGFR-positive cancers + + + + 30591457 + + + + + + + + 2019 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 12 + 10 + 37 + 0 + + + + + + + 18 + A novel complex is identified between TROY and EGFR, which is mediated predominantly by the cysteine-rich CRD3 domain of TROY. Glioblastoma tumors with elevated TROY expression have a statistically positive correlation with increased EGFR expression. EGFR activation is regulated by TROY which modulates EGFR internalization. + + + + 29117939 + + + + + + + + 2019 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 12 + 10 + 35 + 0 + + + + + + + 18 + Results show that the GluN2B is a substrate of EGFR in glioma cells. EGFR phosphorylates the COOH-terminal domain of GluN2B and thereby enhances glutamate-NMDAR signaling and consequent cell migration in EGFR-overexpressing glioma cells. Along with previous results of its interaction with xCT to enhance glutamate release, EGFR seems to play a central role in the signaling crosstalk between xCT and GluN2B in glioma cells. + + + + 30298963 + + + + + + + + 2019 + 1 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 5 + 11 + 28 + 0 + + + + + + + 18 + The scFv may exhibit a potential application for the detection of EGFR-overexpressing cancer cells. + + + + 29185855 + + + + + + + + 2019 + 1 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 5 + 11 + 25 + 0 + + + + + + + 18 + we conclude that tyrosine phosphorylation is not required for oncogenic activity of lung-cancer-derived mutant EGFR, suggesting these mutants can lead to cellular transformation by an alternative mechanism independent of EGFR phosphorylation. + + + + 29464683 + + + + + + + + 2019 + 1 + 5 + 10 + 2 + 0 + + + + + + + + + 2019 + 1 + 5 + 10 + 25 + 0 + + + + + + + 18 + Amphiregulin contained in non-small-cell lung carcinoma-derived exosomes induces osteoclast differentiation through the activation of EGFR pathway. + + + + 28600504 + + + + + + + + 2018 + 12 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 29 + 12 + 32 + 0 + + + + + + + 18 + Combine vorinostat with an EGFRTKI to reverse EGFRTKI resistance in NSCLC. + + + + 30365122 + + + + + + + + 2018 + 12 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 29 + 12 + 2 + 0 + + + + + + + 18 + Our results show that the chimeric EGFETA toxin is extremely effective against EGFRpositive cancers and raises the potential to further develop this chimera for use in targeting EGFRpositive tumours resistant to monoclonal antibodies. + + + + 30226622 + + + + + + + + 2018 + 12 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 29 + 11 + 21 + 0 + + + + + + + 18 + The feasibility of using the radiocobalt labeled antiEGFR affibody conjugate ZEGFR:2377 as an imaging agent. + + + + 30320363 + + + + + + + + 2018 + 12 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 29 + 10 + 46 + 0 + + + + + + + 18 + In comparison of all transfection complexes, 454 lipopolyplexes modified with the bidentate PEG-GE11 agent show the best, EGFR-dependent uptake as well as luciferase and NIS gene expression into + + + + 28877405 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 12 + 14 + 0 + + + + + + + 18 + EGFR amplification was higher in the OSCC group than in the control group (P=0.018) and was associated with advanced clinical stage (P=0.013), regardless of age. Patients with EGFR overexpression had worse survival rates, as did patients who had T3-T4 tumours and positive margins. EGFR overexpression has a negative impact on disease progression. + + + + 29395668 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 57 + 0 + + + + + + + 18 + Clonal analysis shows that the dominant JAK2 V617F-positive clone in Polycythemia Vera harbors EGFR C329R substitution, thus this mutation may contribute to clonal expansion. + + + + 28550306 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 56 + 0 + + + + + + + 18 + Baseline Circulating tumor cell count could be a predictive biomarker for EGFR-mutated and ALK-rearranged non-small cell lung cancer , which allows for better guidance and monitoring of patients over the course of molecular targeted therapies. + + + + 29582563 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 54 + 0 + + + + + + + 18 + High EGFR expression is associated with cystic fibrosis. + + + + 29351448 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 35 + 0 + + + + + + + 18 + This study detected the emergence of T790M mutation within the EGFR cDNA in a subset of erlotinib resistant PC9 cell models through Sanger sequencing and droplet digital PCR-based methods, demonstrating that T790M mutation can emerge via de novo events following treatment with erlotinib. + + + + 29909007 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 22 + 0 + + + + + + + 18 + these results suggest a mechanism for EGFR inhibition to suppress respiratory syncytial virus by activation of endogenous epithelial antiviral defenses + + + + 29411775 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 22 + 0 + + + + + + + 18 + the present study demonstrated that miR145 regulates the EGFR/PI3K/AKT signaling pathway in patients with nonsmall cell lung cancer. + + + + 30226581 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 18 + 0 + + + + + + + 18 + among NSCLC patients treated with EGFR-TKI, those with T790M mutations were found to frequently also show 19 dels, compared to T790M-negative patients. In addition, T790M-positive patients had a longer PFS. Therefore, screening these patients for T790M mutations may help in improving survival. + + + + 30150444 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 9 + 0 + + + + + + + 18 + High EGFR expression is associated with Breast Carcinoma. + + + + 30139236 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 8 + 0 + + + + + + + 18 + results showed that CAV-1 could promote anchorage-independent growth and anoikis resistance in detached SGC-7901 cells, which was associated with the activation of Src-dependent epidermal growth factor receptor-integrin beta signaling as well as the phosphorylation of PI3K/Akt and MEK/ERK signaling pathways + + + + 30088837 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 11 + 0 + 0 + + + + + + + 18 + our results indicate that FOXK2 inhibits the malignant phenotype of clear-cell renal cell carcinoma and acts as a tumor suppressor possibly through the inhibition of EGFR. + + + + 29368368 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 58 + 0 + + + + + + + 18 + Different Signaling Pathways in Regulating PD-L1 Expression in EGFR Mutated Lung Adenocarcinoma + + + + 30454551 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 45 + 0 + + + + + + + 18 + EGFR mutation status in advanced non-small cell lung cancer (NSCLC) patients altered significantly + + + + 30454543 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 45 + 0 + + + + + + + 18 + internal tandem duplication of kinase domain delineates a genetic subgroup of congenital mesoblastic nephroma transcending histological subtypes + + + + 29915264 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 44 + 0 + + + + + + + 18 + The expression level of EGFR increased along with higher stages and pathologic grades of BTCC, and the obviously increased expression of HER-2 was statistically associated with clinical stages and tumor recurrence. In addition, the expression level of HER-2 increased along with the higher clinical stage of BTCC. EGFR expression and HER-2 levels were positively associated in BTCC samples. + + + + 30296252 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 43 + 0 + + + + + + + 18 + Results show that GGA2 interacts with EGFR cytoplasmic domain to stabilize its expression and reducing its lysosomal degradation. + + + + 29358589 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 31 + 0 + + + + + + + 18 + Herein we report a rare case presenting as multiple lung adenocarcinomas with four different EGFR gene mutations detected in three lung tumors. + + + + 29577613 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 31 + 0 + + + + + + + 18 + combination therapy of apatinib with icotinib for primary acquired resistance to icotinib may be an option for patients with advanced pulmonary adenocarcinoma with EGFR mutations, but physicians must also be aware of the side effects caused by such therapy. + + + + 29575765 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 31 + 0 + + + + + + + 18 + The ratio of sFlt-1/sEGFR could be used as a novel candidate biochemical marker in monitoring the severity of preterm preeclampsia. sEndoglin and sEGFR may be involved in the pathogenesis of small for gestational age in preterm preelampsia. + + + + 30177039 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 31 + 0 + + + + + + + 18 + Study supports the involvement of EGFR, HER2 and HER3 in BCC aggressiveness of and in tumor differentiating towards different histological subtypes. + + + + 30173251 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 31 + 0 + + + + + + + 18 + Study confirmed prognostic effect of EGFR and VEGFR2 for recurrent disease and survival rates in patients with epithelial ovarian cancer. + + + + 30066848 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 20 + 0 + + + + + + + 18 + The data indicate that diagnostic or therapeutic chest radiation may predispose patients with decreased stromal PTEN expression to secondary breast cancer, and that prophylactic EGFR inhibition may reduce this risk. + + + + 30018330 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 15 + 0 + + + + + + + 18 + suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network. + + + + 29233889 + + + + + + + + 2018 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 22 + 10 + 13 + 0 + + + + + + + 18 + study observed the occurrence of not only EGFR C797S mutation but also L792F/Y/H in three NSCLC clinical subjects with acquired resistance to osimertinib treatment + + + + 28093244 + + + + + + + + 2018 + 12 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 8 + 11 + 35 + 0 + + + + + + + 18 + Data show that the expression level of epidermal growth factor-like domain 7 (EGFL7) and epidermal growth factor receptor (EGFR) in invasive growth hormone-producing pituitary adenomas (GHPA) was much higher than that of non-invasive GHPA. + + + + 29951953 + + + + + + + + 2018 + 12 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 12 + 1 + 11 + 4 + 0 + + + + + + + 18 + Concurrent mutations, in genes such as CDKN2B or RB1, were associated with worse clinical outcome in lung adenocarcinoma patients with EGFR active mutations. + + + + 29343775 + + + + + + + + 2018 + 11 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 24 + 12 + 5 + 0 + + + + + + + 18 + ER-alpha36/EGFR signaling loop promotes growth of hepatocellular carcinoma cells + + + + 29481815 + + + + + + + + 2018 + 11 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 17 + 12 + 26 + 0 + + + + + + + 18 + High EGFR expression is associated with tumor-node-metastasis in nonsmall cell lung cancer. + + + + 30106450 + + + + + + + + 2018 + 11 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 17 + 11 + 57 + 0 + + + + + + + 18 + High EGFR expression is associated with gefitinib resistance in lung cancer. + + + + 30106446 + + + + + + + + 2018 + 11 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 17 + 11 + 57 + 0 + + + + + + + 18 + High EGFR expression is associated with colorectal cancer. + + + + 30106444 + + + + + + + + 2018 + 11 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 17 + 11 + 57 + 0 + + + + + + + 18 + Data suggest that Thr264 in TRPV3 is key ERK1 phosphorylation site mediating EGFR-induced sensitization of TRPV3 to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 = transient receptor potential cation channel subfamily V member-3; ERK1 = extracellular signal-regulated kinase-1; EGFR = epidermal growth factor receptor) + + + + 29084846 + + + + + + + + 2018 + 11 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 17 + 10 + 10 + 0 + + + + + + + 18 + The EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations. + + + + 30217176 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 12 + 0 + 0 + + + + + + + 18 + The results reveal that the EGF-STAT3 signaling pathway promotes and maintains colorectal cancer (CRC)stemness. In addition, a crosstalk between STAT3 and Wnt activates the Wnt/beta-catenin signaling pathway, which is also responsible for cancer stemness. Thus, STAT3 is a putative therapeutic target for CRC treatment. + + + + 30068339 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 11 + 21 + 0 + + + + + + + 18 + EGFR-containing exosomes derived from cancer cells could favour the development of a liver-like microenvironment promoting liver-specific metastasis. + + + + 28393839 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 11 + 21 + 0 + + + + + + + 18 + This result indicated that T790M mutation is not only associated with EGFR-TKI resistance but also may play a functional role in the malignant progression of lung adenocarcinoma. + + + + 29887244 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 11 + 19 + 0 + + + + + + + 18 + LOX regulates EGFR cell surface retention to drive tumour progression. + + + + 28416796 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 10 + 51 + 0 + + + + + + + 18 + In a Han Chinese population, EGFR gene polymorphisms, rs730437 and rs1468727 and haplotype A-C-C were shown to be possible protective factors for the development of Alzheimer's Disease. + + + + 30026459 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 10 + 44 + 0 + + + + + + + 18 + EGFR proteins at different cellular locations in lung adenocarcinoma might influence the biology of cancer cells and are an independent indicator of more favorable prognosis and treatment response. + + + + 29950164 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 10 + 6 + 0 + + + + + + + 18 + Here we report the crystal structure of EGFR T790M/C797S/V948R in complex with EAI045, a new type of EGFR TKI that binds to EGFR reversibly and not relying on Cys 797. + + + + 29802850 + + + + + + + + 2018 + 11 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 10 + 10 + 4 + 0 + + + + + + + 18 + Overexpression of miR-452-3p promoted cell proliferation and mobility and suppressed apoptosis. MiR-452-3p enhanced EGFR and phosphorylated AKT (pAKT) expression but inhibited p21 expression level. MiR-452-3p promoted hepatocellular carcinoma (HCC)cell proliferation and mobility by directly targeting the CPEB3/EGFR axis + + + + 29332449 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 50 + 0 + + + + + + + 18 + This study shows that the D2A sequence of the UPAR induces cell growth through alphaVbeta3 integrin and EGFR. + + + + 29184982 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 24 + 0 + + + + + + + 18 + BRAF and EGFR inhibitors are able to synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells + + + + 29534162 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 13 + 0 + + + + + + + 18 + This study confirms a direct correlation between MSI1 and EGFR and may support the important role of MSI1 in activation of EGFR through NOTCH/WNT pathways in esophageal squamous cell carcinoma. + + + + 30202417 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 6 + 0 + + + + + + + 18 + Three lines of tyrosine kinase inhibitors (TKIs) therapy can prolong survival in non-small cell lung cancer (NSCLC) patients. Elderly patients can benefit from TKI therapy. EGFR mutation-positive patients can benefit from second-line or third-line TKI therapy. + + + + 29266865 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 3 + 0 + + + + + + + 18 + EGFR 19Del and L858R mutations are good biomarkers for predicting the clinical response of EGFR-TKIs. 19Del mutations may have a better clinical outcome. + + + + 29222872 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 11 + 2 + 0 + + + + + + + 18 + HMGA2-EGFR constitutively induced a higher level of phosphorylated STAT5B than EGFRvIII. + + + + 29193056 + + + + + + + + 2018 + 11 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 11 + 3 + 10 + 55 + 0 + + + + + + + 18 + This study provides important evidence of higher levels of agreement of PD-L1 expression in pulmonary metastasis compared with in multiple primary lung cancer, and high positivity of PD-L1 expression in pulmonary metastatic lesions with wild-type EGFR in an Asian population. + + + + 29254651 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 11 + 46 + 0 + + + + + + + 18 + Authors observed that delta-catenin plays a key role in EGFR stability and downstream signaling. delta-Catenin competes with c-Cbl for EGFR binding, which results in a reduction of binding between c-Cbl and EGFR and thus decreases the ubiquitination of EGFR. + + + + 29629558 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 11 + 35 + 0 + + + + + + + 18 + A significant association was found with EGFR overexpression and tumor grade in urinary bladder neoplasm patients. + + + + 29879970 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 11 + 21 + 0 + + + + + + + 18 + EGFR L861Q Mutation is associated with Metastatic Solid-pseudopapillary Neoplasm of the Pancreas. + + + + 29695402 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 11 + 6 + 0 + + + + + + + 18 + High EGFR expression is associated with colorectal carcinoma. + + + + 29970694 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 10 + 32 + 0 + + + + + + + 18 + EGFR mutation was an independent predictive and prognostic factor for developing BM, which was also a positive predictive factor for overall survival of patients who developed BM. + + + + 29970656 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 10 + 32 + 0 + + + + + + + 18 + Double Mutations of EGFR and ALK Gene in Non-small Cell Lung Cancer + + + + 30201068 + + + + + + + + 2018 + 10 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 27 + 10 + 29 + 0 + + + + + + + 18 + Anticancer effects of isofraxidin against A549 human lung cancer cells via the EGFR signaling pathway. + + + + 29750303 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 12 + 7 + 0 + + + + + + + 18 + Data indicate a mechanism of epidermal growth factor receptor (EGFR) regulation through the importin beta family member RAN-binding protein 6 (RanBP6). + + + + 29229958 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 11 + 59 + 0 + + + + + + + 18 + EGFR Double Mutation in Non-small Cell Lung Cancer + + + + 30172266 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 11 + 18 + 0 + + + + + + + 18 + API was demonstrated to inhibit the migration/invasion of NSCLC cells harboring different EGFR statuses via suppressing the Snail/Slug-mediated EMT..CD26 may be a useful biomarker for predicting NSCLC progression. API effectively suppressed lung cancer progression by targeting the CD26-Akt-Snail/Slug signaling pathway + + + + 30134935 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 11 + 17 + 0 + + + + + + + 18 + Our results indicate a potential prognostic role for MAP17 in lung tumours, with particular relevance in lung adenocarcinomas, and highlight the predictive pot0065ntial of this membrane-associated protein for platinum-based therapy and EGFR inhibitor efficacy. Furthermore, we propose bortezomib treatment as a novel and efficacious therapy for lung adenocarcinomas exhibiting high MAP17 expression. + + + + 30119639 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 11 + 17 + 0 + + + + + + + 18 + CEACAM6 promoted oral squamous cell carcinoma cell invasion, migration, cytoskeletal rearrangement, and metastasis via interaction with EGFR and enhancing it activation. + + + + 28892050 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 11 + 13 + 0 + + + + + + + 18 + CLDN3 expression and negative EGFR expression are associated with BRCA1 mutations in triple-negative breast cancers. + + + + 30142017 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 10 + 37 + 0 + + + + + + + 18 + characteristics of the expression of epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS) in non-small cell lung cancer + + + + 30037374 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 10 + 31 + 0 + + + + + + + 18 + EGFR Over-expression and Mutations Leading to Biological Characteristics Changes of Human Lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling Pathway + + + + 30037369 + + + + + + + + 2018 + 10 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 20 + 10 + 31 + 0 + + + + + + + 18 + Study identifies a novel role for PRP4K in regulating the endosomal trafficking of EGFR leading to altered anoikis sensitivity in epithelial cancer cells. + + + + 28892043 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 12 + 3 + 0 + + + + + + + 18 + Telbivudine treatment resulted in increased levels of serum KLK8 protein. Furthermore, eGFR increase was associated with body height-adjusted, post-treatment KLK8 levels. + + + + 29936485 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 11 + 54 + 0 + + + + + + + 18 + We reported that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor re-administration (TKI-R) might be salvage therapy in patients with advanced non-small cell lung cancer after recovery from EGFR-TKI-induced interstitial lung disease (ILD) + + + + 29936470 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 11 + 54 + 0 + + + + + + + 18 + EGFR Polymorphisms Are Associated with Colorectal Cancer in Patients with Lynch Syndrome. + + + + 30275229 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 11 + 28 + 0 + + + + + + + 18 + miR-615 plays a tumor suppressor role in glioblastoma cell proliferation, migration and invasion by targeting EGFR expression. + + + + 29605294 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 10 + 37 + 0 + + + + + + + 18 + The main limitation of EGFRTKI therapy is the heterogeneity of lung cancer harboring EGFRsensitive mutations. + + + + 29917169 + + + + + + + + 2018 + 10 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 13 + 10 + 29 + 0 + + + + + + + 18 + The first- and second-generation EGFR tyrosine kinase inhibitors (TKIs), erlotinib, gefitinib and afatinib, have demonstrated robust efficacy for the first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC), and are approved in this indication + + + + 29336166 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 12 + 24 + 0 + + + + + + + 18 + The rate of EGFR mutation was significantly higher in female and non-smoker patients. In TTF-1 positive cases EGFR mutation was more frequent. Age of the patients over 62-year old was correlated with KRAS mutations. The concordance between ALK IHC and FISH was 58.3%. The MET protein in the cases with MET amplification was 100% positive. + + + + 28756651 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 12 + 17 + 0 + + + + + + + 18 + The cobas assay is a reliable and rapid method for detecting EGFR mutations in plasma cfDNA. + + + + 29854785 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 12 + 10 + 0 + + + + + + + 18 + Genistein (GE) inhibited the growth of human Cholangiocarcinoma (CCA) cell lines by reducing the activation of EGFR and AKT, and by attenuating the production of IL6. E2 and ER were also involved in the growth-inhibitory effect of GE in CCA cells. + + + + 29693152 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 12 + 1 + 0 + + + + + + + 18 + In the presence of the mutant EGFR (EGFRvIII), IL-13Ralpha2 promotes glioblastoma multiforme cell proliferation in vitro and in vivo. + + + + 29203859 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 11 + 23 + 0 + + + + + + + 18 + Molecular dynamics simulations and umbrella sampling of WT and mutant EGFR suggest a model in which activating insertion mutations increase catalytic activity by relieving key autoinhibitory interactions associated with alphaC-helix movement and by lowering the transition free energy. + + + + 30104348 + + + + + + + + 2018 + 10 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 10 + 6 + 10 + 24 + 0 + + + + + + + 18 + qPCR-Invader just needs a common real-time PCR device to accomplish quantification of EGFR mutations, and the fluorescence probes are universal for any target detection + + + + 30128808 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 11 + 59 + 0 + + + + + + + 18 + EGFR mutations were associated with the elevated serum carcinoembryonic antigen levels. Those with the exon 19 deletion have less favourable prognosis than have those with the exon 21 mutation. + + + + 29849818 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 11 + 18 + 0 + + + + + + + 18 + Thus, PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma was associated with BIM and VEGFA mRNA expression and with shorter PFS after gefitinib therapy. + + + + 29767258 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 11 + 16 + 0 + + + + + + + 18 + EGFr seems to be important for both urothelial proliferation and the formation of the three dimensional structure of the epithelium. + + + + 29508172 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 10 + 40 + 0 + + + + + + + 18 + EGFR-family phosphosites achieve a trade-off between minimizing off-pathway phosphorylation and maintaining the ability to recruit the diverse complement of effectors required for downstream pathway activation + + + + 30012625 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 10 + 38 + 0 + + + + + + + 18 + suggests SIRT1 may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma, and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in esophageal squamous cell carcinoma + + + + 29625788 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 10 + 16 + 0 + + + + + + + 18 + In patients with NSCLC treated with stereotactic radiosurgery for brain metastases, the presence of EGFR mutations is associated with a higher CRR, longer time for distant brain control, and better brain progression-free survival. + + + + 29111173 + + + + + + + + 2018 + 9 + 29 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 29 + 10 + 8 + 0 + + + + + + + 18 + Results show that EGFR expression is upregulated in GC (gastric cancer) tumors. Also, EGFR was revealed as a putative target of miR138 and miR204 which bound to the 3'UTR of EGFR mRNA. + + + + 29693184 + + + + + + + + 2018 + 9 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 22 + 11 + 49 + 0 + + + + + + + 18 + Histopathological features, i.e. presence of low-grade areas, may play a role in classifying Glioblastoma (GB) into primary and secondary. EGFR has a pivotal role in gliomagenesis. Combination of p53 and EGFR alone may not be sufficient to clarify GB into primary and secondary. + + + + 29664032 + + + + + + + + 2018 + 9 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 22 + 11 + 48 + 0 + + + + + + + 18 + Asymmetric heterodimers of HER1/HER2 complexes were analyzed using molecular dynamics simulations. HER2 kinase domain prefers to serve as the receiver rather than the activator. Key binding residues of this dimer complex at N lobe of HER2 is ALA683 and at C lobe of HER1 are GLU914, GLU917, and ASP930. + + + + 29280017 + + + + + + + + 2018 + 9 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 22 + 10 + 54 + 0 + + + + + + + 18 + Progesterone receptor, EGFR, and galectin-3 are expressed differentially in uterine smooth muscle tumors. + + + + 29729689 + + + + + + + + 2018 + 9 + 22 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 22 + 10 + 42 + 0 + + + + + + + 18 + This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations. + + + + 27501781 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 12 + 3 + 0 + + + + + + + 18 + Reactive oxygen species-mediated EGFR/MEK/ERK/HIF-1A loop regulates glucose metabolism in pancreatic cancer. + + + + 29702094 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 11 + 49 + 0 + + + + + + + 18 + PTPN12 plasmid transfection increased PTPN12 mRNA and protein expressions, suppressed cell proliferation and migration, reduced EGFR level, and enhanced caspase 3 activity compared with control and empty plasmid groups + + + + 29634414 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 11 + 46 + 0 + + + + + + + 18 + Positive association was found between EGFR mutations determined by IHC and both EGFR overexpression and increased gene copy number. Positive association was detected between EGFR mutations, high tumor grade and clinical stage in NSCLC. + + + + 29556606 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 11 + 37 + 0 + + + + + + + 18 + Sortilin is a regulator of EGFR intracellular trafficking that promotes receptor internalization and limits signaling, which in turn impacts tumor growth. + + + + 29084952 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 11 + 26 + 0 + + + + + + + 18 + Resistin promoted lung adenocarcinoma metastasis through the TLR4/Src/EGFR/PI3K/NF-kappaB pathway. + + + + 29927028 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 10 + 46 + 0 + + + + + + + 18 + Five patients (16%) had other EGFR activating mutations. + + + + 29807396 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 10 + 44 + 0 + + + + + + + 18 + The role of beta-catenin in EGFR-TKIs-treated cancer stem cell-like population(s). + + + + 29154817 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 10 + 40 + 0 + + + + + + + 18 + findings identify acquired amplification of YES1 as a recurrent and targetable mechanism of resistance to EGFR inhibition in EGFR-mutant lung cancers and demonstrate the utility of transposon mutagenesis in discovering clinically relevant mechanisms of drug resistance. + + + + 29875142 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 10 + 33 + 0 + + + + + + + 18 + In this study, authors analyzed the immunoexpression of EGFR, HER2 (EGFR2) and HER3 (EGFR3) in 41 cases of serous borderline ovarian tumors and carcinomas, in relation to the degree of differentiation and tumor stage. + + + + 29556616 + + + + + + + + 2018 + 9 + 8 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 8 + 10 + 21 + 0 + + + + + + + 18 + Structural analysis demonstrated that the coupling of synthetic, natural or newly designed compounds impacts the conformational space of EGFR and HER2 differently. + + + + 29329808 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 12 + 2 + 0 + + + + + + + 18 + This review also discusses the current prognostic status of EGFR in glioblastomas and other gliomas, and highlights gaps in previous studies. This serves as an update for the medical community about the role of EGFR gene alterations in gliomas and specifically glioblastomas, as a means for targeted treatment and prognosis. + + + + 28885661 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 55 + 0 + + + + + + + 18 + EGFR is confirmed a poor prognostic factor in resected gastric cancers. We firstly describe a mutually exclusive overexpression of EGFR and AKT1 with potential prognostic implications, suggesting the relevance of this pathway for the growth of gastric cancers. + + + + 29278885 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 55 + 0 + + + + + + + 18 + Correlation exists between EGFR mutations and histologic subtypes of invasive adenocarcinoma or air bronchograms on CT images, which could use to predict EGFR mutation status in patients with pulmonary adenocarcinoma. + + + + 29516992 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 52 + 0 + + + + + + + 18 + The detection of EGFR mutation in peripheral blood can be applied as an effective index for EGFR-TKI (Gefitinib) treatment in patients with esophageal carcinoma. + + + + 29516969 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 52 + 0 + + + + + + + 18 + High EGFR expression is associated with drug resistance in non-small cell lung cancer. + + + + 29344640 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 28 + 0 + + + + + + + 18 + EGFR mutations are associated with lung cancers. In the H1975 cells, 72% of the reads harbored both L858R and T790M mutations, and 22% of the reads harbored neither mutation. + + + + 29117310 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 18 + 0 + + + + + + + 18 + Although blood had a better specificity for detecting EGFR mutations, the absence of blood positivity should not necessarily be construed as confirmed negativity. Patients with negative results for blood should decidedly undergo further biopsies to ascertain EGFR mutations + + + + 29552976 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 18 + 0 + + + + + + + 18 + Study demonstrated the radiological and clinical features could be used to prognosticate epidermal growth factor receptor mutation subtypes in exon 19 and 21. + + + + 28336963 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 11 + 1 + 0 + + + + + + + 18 + Lung adenocarcinoma patients positive for the EGFR Exon 21 L858R mutation had a higher positive rate of intraoperative pleural lavage cytology than those not possessing EGFR mutations. + + + + 29093430 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 10 + 22 + 0 + + + + + + + 18 + Our results suggest that erlotinib-treated patients with wild-type EGFR develop resistance through other mechanisms than T790M, and molecular diagnostics aimed at identifying the responsible events should not focus on T790M. + + + + 29448920 + + + + + + + + 2018 + 9 + 1 + 10 + 2 + 0 + + + + + + + + + 2018 + 9 + 1 + 10 + 20 + 0 + + + + + + + 18 + Silencing filamin A (FLNa) expression in lung cancer cell line A549 cells promoted proliferation, migration, and invasiveness of A549 cells by enhancing the activation of epidermal growth factor receptor and ERK signaling pathway. + + + + 29272322 + + + + + + + + 2018 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 25 + 11 + 40 + 0 + + + + + + + 18 + Authors show that NRF2 regulates both basal and inducible expression of HER1, as treatment of ovarian cancer cells (PEO1, OVCAR3, and SKOV3) with NRF2 activator tBHQ inducing HER1, while inhibition of NRF2 by siRNA knockdown or with retinoid represses HER1. + + + + 29410730 + + + + + + + + 2018 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 25 + 11 + 23 + 0 + + + + + + + 18 + the present study aimed to investigate the sensitivity of distinct gefitinib-resistant non-small cell lung cancer (NSCLC)cell lines to chemotherapy in order to help select effective treatment regimens for patients with EGFR-TKI resistance..the present study revealed that gefitinib-resistant NSCLC cells carrying the T790M mutation were sensitive to taxane chemotherapy + + + + 29393480 + + + + + + + + 2018 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 25 + 10 + 48 + 0 + + + + + + + 18 + T790 M epidermal growth factor receptor (EGFR) mutation occurred more frequently in patients with the exon 19 deletion than in those with exon 21 L858R, which gave the survival benefit of the T790 M mutation [Review]. + + + + 29409466 + + + + + + + + 2018 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 25 + 10 + 7 + 0 + + + + + + + 18 + High EGFR methylation is associated with resistance to cetuximab in triple-negative breast cancer. + + + + 28643125 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 12 + 3 + 0 + + + + + + + 18 + EGFR TKIs (gefitinib and erlotinib) are used as the preferred first-line treatment while chemotherapy is more frequently administered as a second- and third-line option in routine clinical practice in Spain. + + + + 29382302 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 11 + 49 + 0 + + + + + + + 18 + EGFR L858R and Del-19 is associated with Differential efficacy of cisplatin plus pemetrexed in non-squamous non-small cell lung cancer. + + + + 29291705 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 11 + 11 + 0 + + + + + + + 18 + Radiotherapy could up-regulate the PD-L1 expression through the pathways downstream of EGFR in glioma. + + + + 29396299 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 11 + 9 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with response to therapy in lung adenocarcinoma. + + + + 29387978 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 11 + 9 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with response to therapy in lung adenocarcinoma. + + + + 29387949 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 11 + 9 + 0 + + + + + + + 18 + Up-regulation of serum EGFR in a network analysis was associated with an elevated risk for the development of coronary artery disease. + + + + 29328373 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 10 + 41 + 0 + + + + + + + 18 + PD-L1 expression is associated with disease stage and type of EGFR mutation. PD-L1 positivity might be associated with worse RFS among patients with surgically treated EGFR-mutant NSCLC. + + + + 28301925 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 10 + 40 + 0 + + + + + + + 18 + Our multiple screening strategies confirmed that the druggable sub-pocket was crucial to strong EGFR-ligand binding. The essential pharmacophoric features of ligands provided viewpoints for new inhibitors envisaging, and predicted scaffolds could used as anticancer agents against selected EGFR mutated isoforms. + + + + 29369008 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 10 + 11 + 0 + + + + + + + 18 + results demonstrated that PLAUR induces geftinib-resistance through EGFR/p-AKT/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR could be a novel therapeutic target for gefitinib-resistant NSCLC patients. + + + + 29961070 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 10 + 5 + 0 + + + + + + + 18 + Low EGFR expression is associated with glioma progression. + + + + 28575494 + + + + + + + + 2018 + 8 + 18 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 18 + 10 + 3 + 0 + + + + + + + 18 + Collectively, these data suggest that a small pool of active EGFRs is sufficient to drive tumorigenesis by signaling primarily through the Ras-MAPK pathway. + + + + 29268862 + + + + + + + + 2018 + 8 + 11 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 11 + 12 + 1 + 0 + + + + + + + 18 + Evaluated the safety and antitumor efficacy of afatinib combined with carboplatin and pemetrexed in EGFR-mutated non-small-cell lung cancer (NSCLC) patients. + + + + 30061238 + + + + + + + + 2018 + 8 + 11 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 11 + 10 + 10 + 0 + + + + + + + 18 + Here, we discover that intersectin-s binds DENND2B, a guanine nucleotide exchange factor for the exocytic GTPase Rab13, and this interaction promotes recycling of ligand-free EGFR to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR with important implications for cancer. + + + + 29030480 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 12 + 23 + 0 + + + + + + + 18 + that the rs401681 polymorphism in the TERT-CLPTM1L locus contributes to lung carcinogenesis only in patients harboring an EGFR mutation + + + + 29033187 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 12 + 22 + 0 + + + + + + + 18 + Loss of EGFR could be proposed as a potential acquired resistance mechanism of AZD9291 in EGFR-mutant NSCLC cells with an EMT phenotype. Despite the loss of EGFR, the activation of MAPK pathway which had crosstalk with AKT pathway could maintain the proliferation and survival of resistant cells. + + + + 29797219 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 11 + 54 + 0 + + + + + + + 18 + EGFR mutation is associated with advanced non-small cell lung cancer. + + + + 28497422 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 11 + 48 + 0 + + + + + + + 18 + The prognosis of patients with advanced NSCLC harboring EGFR mutations with miliary pulmonary metastasis demonstrated significantly worse outcomes compared to those without miliary pulmonary metastasis. + + + + 29858682 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 11 + 19 + 0 + + + + + + + 18 + Minimally invasive plasma circulating tumor DNA (ctDNA) evolved as an alternative for detection of EGFR T790M mutation when tumor genotyping is not feasible. Although a positive T790M result from ctDNA analysis is actionable, caution should be exercised in interpreting negative plasma results + + + + 29292710 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + This review article sheds light on the safety profile of first-, second-, and third-generation EGFR TKIs based on data obtained from several clinical trials conducted in nonsmall cell lung cancer patients and highlights trials comparing these agents with the conventional chemotherapy agents + + + + 29292709 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + This review focuses on the methods for molecular testing of tissue and liquid biopsy specimens for EGFR mutations, particularly EGFR T790M mutation. + + + + 29292708 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + The purpose of this review article is to present an updated clinical preview of EGFR TKIs over conventional treatment, mainly radiation therapy to consider them as "use first" agents against EGFR T790M mutation in the treatment of patients with advanced nonsmall cell lung cancer . + + + + 29292707 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + tyrosine kinase inhibitors (TKIs) have proven to be better treatment option in EGFR-positive patients as compared to chemotherapy. Third-generation TKIs (osimertinib) promise to bring optimal and improved care for nonsmall cell lung cancer cases failing first-line TKI treatment. + + + + 29292706 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + This article reviews the emerging data regarding EGFR mutations and clinical evidence on third-generation agents against EGFR T790M mutation in the treatment of patients with advanced Non-small cell lung cancer (NSCLC) . It also reviews the role of repeat biopsy in improving the success rates of treatment of EGFR T790M-derived drug-resistant NSCLC + + + + 29292704 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 51 + 0 + + + + + + + 18 + ASP8273 was well tolerated and promoted antitumor activity in patients with EGFR-mutant lung cancer with disease progression on prior EGFR TKI therapy + + + + 28954786 + + + + + + + + 2018 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2018 + 8 + 4 + 10 + 48 + 0 + + + + + + + 18 + The prognosis of patients with the single rare non-small cell lung cancer EGFR mutations treated with tyrosine kinase inhibitors is poor. + + + + 29270745 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 11 + 46 + 0 + + + + + + + 18 + In this first-in-human study for the combination, addition of the PI3K inhibitor pictilisib to the EGFR tyrosine kinase inhibitor erlotinib resulted in toxicity that led to dose and schedule modifications to identify a tolerable recommended phase II dose of 340 mg pictilisib on a "5 days on, 2 days off" schedule plus 100 mg erlotinib daily. + + + + 28798270 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 11 + 38 + 0 + + + + + + + 18 + Modulation of MEK/ERK-dependent Bim and Mcl-1 degradation critically mediates sensitivity and resistance of EGFR-mutant non-small cell lung cancer (NSCLC)cells to AZD9291 and hence is an effective strategy to overcome acquired resistance to AZD9291 + + + + 28765329 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 10 + 45 + 0 + + + + + + + 18 + We found no evidence for effects of CA-SSR-1 length or zygosity in patients with oral cancer on disease-free or overall survival. In conclusion, the data from this study suggest no prognostic value of CA-SRR-1 in these patients. + + + + 28150908 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 10 + 28 + 0 + + + + + + + 18 + Our results suggest that Bcl-xL plays a key role in the apoptosis resistance of T790M-positive non-small cell lung cancer (NSCLC) and that dasatinib combined with clinically relevant T790M-selective EGFR-TKIs is potentially effective in overcoming resistance to first-generation EGFR-TKIs in NSCLC patients with acquired T790M + + + + 28839001 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 10 + 6 + 0 + + + + + + + 18 + We identified unique and tumor-specific tyrosine phosphorylation rewiring in tumors resistant to treatment with the irreversible third-generation EGFR-inhibitor, osimertinib, or the novel dual-targeting EGFR/Met antibody, JNJ-61186372. + + + + 28830985 + + + + + + + + 2018 + 7 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 28 + 10 + 3 + 0 + + + + + + + 18 + In this Review, we follow the epidermal growth factor (EGF) receptor (EGFR) from ligand engagement, through its voyage on endosomes and, ultimately, to its destruction in the lysosome. + + + + 29180516 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 11 + 52 + 0 + + + + + + + 18 + Meta-analysis found that EGFR rs2252586 mutation was significantly associated with glioma risk + + + + 29208187 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 11 + 23 + 0 + + + + + + + 18 + the present results indicate that the EGFR mutation status and TS and ERCC1 expression can be used as the predictors of overall survival after subsequent second-line treatments for adenocarcinoma non-small-cell lung cancer + + + + 29200955 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 11 + 22 + 0 + + + + + + + 18 + photoimmunotherapy (PIT) is a new targeted treatment for bladder cancer. Panitumumab-IR700-induced PIT selectively kills EGFR-expressing bladder cancer cells in vitro and in vivo and therefore warrants further therapeutic studies in orthotopic xenografts of bladder cancer and ultimately in patients + + + + 28619755 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 10 + 48 + 0 + + + + + + + 18 + After HIP1 expression was blocked by siRNAs, EGFR endocytosis was accelerated and this effect was dependent on the EGF concentration. This endocytosis was colocalized with clathrin expression. These findings indicate that the inhibition of HIP1 can accelerate the endocytosis and degradation of EGFR + + + + 29039605 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 10 + 34 + 0 + + + + + + + 18 + Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines + + + + 28775148 + + + + + + + + 2018 + 7 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 21 + 10 + 28 + 0 + + + + + + + 18 + results indicate that lung cancer cell lines with EGFR mutations (parental cells) do not harbor high PD-L1 protein expression. In addition, EGFR phosphorylation affects PD-L1 expression after acquisition of resistance to EGFR-TKIs. + + + + 29119113 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 11 + 43 + 0 + + + + + + + 18 + he incidence of EGFR mutation in non-small-cell lung cancers is 33% from Kolkata and is typically more common in females and nonsmokers. + + + + 29199710 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 43 + 0 + + + + + + + 18 + T790M mutation was detected in 12 out of the 42 patients in whom EGFR testing was performed on repeat biopsy specimen. Repeat biopsy was able to provide adequate tissue acquisition in only two-thirds of the patients. Liquid biopsy represents an important tool to bridge this gap + + + + 29199706 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 43 + 0 + + + + + + + 18 + the oncogenic potential of LncEGFR, is mediated via positive regulation of EGFR in human tongue cancer. + + + + 29138845 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 38 + 0 + + + + + + + 18 + Data from the initial studies revealed, EGFR mutations, and ALK gene rearrangements are mutually exclusive and as mutual causes of resistance to EGFR-TKIs or ALK-TKIs. However, this mutual exclusivity is being challenged with the increasing evidence showing the coexistence of both EGFR and ALK + + + + 29199696 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 9 + 0 + + + + + + + 18 + Mutation testing at diagnosis is feasible in the vast majority of patients with Stage IV adenocarcinoma of the lung. Patients with EGFR or EML4ALK mutation and those who received pemetrexed maintenance had better clinical outcomes. + + + + 29199690 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 9 + 0 + + + + + + + 18 + Gefitinib maintenance is safe, well-tolerated therapy, produces significant PFS and OS benefit in EGFR mutation-positive patient. It is definitely not a choice for EGFR negative group. In EGFR unknown group, the role of maintenance still needs to be explored. + + + + 29199688 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 9 + 0 + + + + + + + 18 + 43 metastatic adenocarcinoma of lung patients of South Indian origin were enrolled. Twenty patients out of this 43 were epidermal growth factor receptor (EGFR) mutation positive and were started on tyrosine kinase inhibitor (TKI) + + + + 29199681 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 9 + 0 + + + + + + + 18 + EGFR positive patients who were ineligible for a clinical trial due to poor performance status (PS) had lower survival; however, patients with good PS treated off-trial had similar overall survival to that reported in multiple clinical trials. + + + + 29199676 + + + + + + + + 2018 + 7 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 14 + 10 + 9 + 0 + + + + + + + 18 + Subsequent experiments documented that activation of EGFR signaling induced by PD98059 increased the amount of beta-catenin in the nucleus. Taken together, our findings may elucidate a possible mechanism explaining the ineffectiveness of MEK inhibitors in breast cancer treatment and improve our understanding of the role of MEK in cancer + + + + 29048617 + + + + + + + + 2018 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 7 + 12 + 11 + 0 + + + + + + + 18 + Among 718 patients with newly diagnosed metastasised non-squamous NSCLC, 11% (51/447) harboured an EGFR mutation in the exons 18, 19 or 21. + + + + 28557060 + + + + + + + + 2018 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 7 + 11 + 29 + 0 + + + + + + + 18 + EGFR expression stratified most pronounced among HSP90low tumours, where the EGFRhigh phenotype was associated with longer survival + + + + 28765916 + + + + + + + + 2018 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 7 + 10 + 17 + 0 + + + + + + + 18 + The level of EGFR amplification and overexpression significantly predicted response and survival benefit, particularly the mRNA and protein expression level. A combination of mRNA and protein expression may predict efficacy of cetuximab more efficiently. + + + + 28849161 + + + + + + + + 2018 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 7 + 10 + 11 + 0 + + + + + + + 18 + variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53-indenpdent manner + + + + 27502069 + + + + + + + + 2018 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 7 + 7 + 10 + 7 + 0 + + + + + + + 18 + Overexpression of EGFR and MMP-2 plays an essential role in the initiation and progression of non-small-cell lung carcinoma. + + + + 28392461 + + + + + + + + 2018 + 6 + 30 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 30 + 12 + 29 + 0 + + + + + + + 18 + EGFR amplification and EGFRvIII mutation is associated with glioblastoma. + + + + 28453784 + + + + + + + + 2018 + 6 + 30 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 30 + 11 + 24 + 0 + + + + + + + 18 + These findings suggest that increased JUN expression and activity may contribute to gefitinib resistance in non-small cell lung cancer. + + + + 28566434 + + + + + + + + 2018 + 6 + 30 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 30 + 11 + 22 + 0 + + + + + + + 18 + These data further establish a regulatory network where co-activation of Toll/NF-kappaB and EGFR signaling by reactive oxygen species levels in the posterior signaling center niche controls lymph gland hematopoiesis under parasitism. + + + + 29091025 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 11 + 41 + 0 + + + + + + + 18 + The dipole potential exerts significant effects on the ligand binding, clustering and signaling of ErbB1 protein. + + + + 27775011 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 11 + 32 + 0 + + + + + + + 18 + Non-small cell lung cancer (NSCLC) patients with brain metastasis (BMs) had a higher frequency of EGFR mutations than those without. The incidence of BMs in patients with EGFR mutations was higher than in patients with wild-type EGFR. NSCLC patients with BMs had a higher incidence of EGFR mutations and those with mutant EGFR had a higher frequency of BMs. EGFR mutations may promote brain metastasis growth of NSCLC. + + + + 28780743 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 11 + 6 + 0 + + + + + + + 18 + Among 100 mAbs, only one clone EMab-51 (IgG1, kappa) reacted with EGFR in Western blot analysis. Finally, immunohistochemical analyses with EMab-51 showed sensitive and specific reactions against oral cancer cells, warranting the use of EMab-51 to detect EGFR in pathological analyses of EGFR-expressing cancers + + + + 28891752 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 11 + 4 + 0 + + + + + + + 18 + Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. + + + + 28891468 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 11 + 4 + 0 + + + + + + + 18 + We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma + + + + 28490462 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 10 + 37 + 0 + + + + + + + 18 + Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance. + + + + 28196873 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 10 + 34 + 0 + + + + + + + 18 + In patients with advanced non-small-cell lung cancer, multivariate analysis showed that gender, initial EGFR-tyrosine kinase inhibitor response, and progression patterns were significantly associated with EGFR T790M mutation status + + + + 28596108 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 10 + 22 + 0 + + + + + + + 18 + The presence of EGFR mutations did not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma. + + + + 28879441 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 10 + 10 + 0 + + + + + + + 18 + In multivariate analysis, MDM2/MDM4 and EGFR alterations correlated with time-to-treatment failure (TTF)..Some patients with MDM2 family amplification or EGFR aberrations had poor clinical outcome and significantly increased rate of tumor growth after single-agent checkpoint (PD-1/PD-L1) inhibitors + + + + 28351930 + + + + + + + + 2018 + 6 + 23 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 23 + 10 + 8 + 0 + + + + + + + 18 + The findings reveal novel aspects of EGFR regulation of Ewing Sarcoma cells and provide early evidence for antitumor activities of EGFR inhibitors in Ewing Sarcoma. + + + + 29539615 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 12 + 19 + 0 + + + + + + + 18 + Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations and a higher rate of HER2 mutations. Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of EGFR mutations. + + + + 29074543 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 12 + 12 + 0 + + + + + + + 18 + Results provide evidence that EGFR drives GBP1 expression in triple-negative breast cancer cell lines. + + + + 29115931 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 12 + 12 + 0 + + + + + + + 18 + TET1 expression levels were significantly elevated in EGFR mutant samples (P=0.007). Patients with higher TET1 levels showed a trend of better response rates to EGFR inhibitors compared to low TET1 staining levels, although the result was not significant (P=0.08). + + + + 28776568 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 11 + 54 + 0 + + + + + + + 18 + The authors reconfirmed EGFR mutation as a strong predictive marker of Non-Small-Cell Lung Cancer. However, c-MET positivity was not associated with response or progression-free survival, although c-MET overexpression correlated with some clinical characteristics. + + + + 29502124 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 11 + 39 + 0 + + + + + + + 18 + The authors first established that gastrointestinal stromal tumours (GISTs) carrying EGFR mutation are relatively benign tumours. Although EGFR mutations were rarely present in GIST, EGFR seems to play a significant role in the development and progression of GIST. + + + + 28485054 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 11 + 31 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR)-mutated brain metastasis (BMs) were associated with the higher frequencies of multiple metastases and their location in the central area of the brain in comparison to the non-EGFR-mutated BMs. + + + + 29848735 + + + + + + + + 2018 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 16 + 10 + 5 + 0 + + + + + + + 18 + N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4 + + + + 27641064 + + + + + + + + 2018 + 6 + 9 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 9 + 11 + 50 + 0 + + + + + + + 18 + As MUC1 and galectin-3 are both commonly overexpressed in most types of epithelial cancers, their interaction and impact on EGFR activation likely makes important contribution to EGFR-associated tumorigenesis and cancer progression. + + + + 28731466 + + + + + + + + 2018 + 6 + 9 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 9 + 11 + 26 + 0 + + + + + + + 18 + Less differentiated embryonal and undifferentiated small hepatoblastoma cells progressively lose EGFR and ASAP1 expression. This trend is exaggerated in unresectable, locally invasive or metastatic tumors. + + + + 27910913 + + + + + + + + 2018 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 2 + 10 + 43 + 0 + + + + + + + 18 + The overall consequences indicated that recognized leads could be utilized as reference skeletons for new inhibitors envisaging toward EGFR to ameliorate non-small-cell lung carcinoma and other malignant disorders + + + + 28958213 + + + + + + + + 2018 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 2 + 10 + 29 + 0 + + + + + + + 18 + The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer + + + + 28764718 + + + + + + + + 2018 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2018 + 6 + 2 + 10 + 19 + 0 + + + + + + + 18 + Large-scale EGFR testing in the blood of unselected advanced NSCLC patients is feasible and can be used to select patients for targeted therapy when testing cannot be done in tissue. The characteristics and clinical outcomes to TKI treatment of the EGFR-mutated patients identified are undistinguishable from those positive in tumor + + + + 28911086 + + + + + + + + 2018 + 5 + 26 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 26 + 11 + 52 + 0 + + + + + + + 18 + We further confirmed that CDR1as could inhibit the expression of microRNA-7 (miR-7). EGFR is a validated target of miR-7; therefore, CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in hepatocellular carcinoma (HCC)cells. Taken together, we revealed novel functions and underlying mechanisms of CDR1as in HCC cells + + + + 28892615 + + + + + + + + 2018 + 5 + 26 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 26 + 11 + 39 + 0 + + + + + + + 18 + the erlotinib plus bevacizumab combination demonstrated promising efficacy in the B901L xenograft model of EGFR Mut+ non-small cell lung cancer (NSCLC). Re-induction of VEGF and subsequent direct or indirect VEGF-dependent tumor growth was suggested as a major mechanism of erlotinib resistance, and erlotinib plus bevacizumab achieved remarkably prolonged antitumor activity in this model. + + + + 28627678 + + + + + + + + 2018 + 5 + 26 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 26 + 11 + 21 + 0 + + + + + + + 18 + These results revealed that CTSS can regulate EGFR signalling by facilitating EGF-mediated EGFR degradation. + + + + 27387133 + + + + + + + + 2018 + 5 + 26 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 26 + 10 + 33 + 0 + + + + + + + 18 + Molecular dynamics simulations of EGFR suggested that decreased protonation of His(776) at high pH causes conformational changes in the alphaC helix that may stabilize the active form of the kinase resulting in tumorigenesis. + + + + 28874603 + + + + + + + + 2018 + 5 + 26 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 26 + 10 + 11 + 0 + + + + + + + 18 + five EGFR SNPs (rs11506105, rs3752651, rs1468727, rs845552 and rs730437) correlated with glioma patient prognosis + + + + 27437777 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 11 + 56 + 0 + + + + + + + 18 + HER3 phosphorylation by EGFR depends on the ability of EGFR to homo-oligomerize. + + + + 28320942 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 11 + 13 + 0 + + + + + + + 18 + To improve the response to EGFR blockage. + + + + 28910149 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 10 + 44 + 0 + + + + + + + 18 + Results show frequent BRCA2, EGFR, and NTRK1/2/3 mutations in mismatch repair-deficient colorectal cancers , sugggesting personalized medicine strategies to treat the patients with advanced disease who may have no remaining treatment options. + + + + 28591715 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 10 + 39 + 0 + + + + + + + 18 + EGFR mutations can be detected in cytology samples, and 16.7% samples were positive for EGFR mutations + + + + 28730709 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 10 + 36 + 0 + + + + + + + 18 + EGFR increases EYA2 expression via HIF1alpha repression of miR-338-3p and increases breast cancer cell growth, epithelial-to-mesenchymal transition, migration, invasion and lung metastasis in vitro and in a allograft tumor mouse model in vivo. + + + + 28703807 + + + + + + + + 2018 + 5 + 19 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 19 + 10 + 28 + 0 + + + + + + + 18 + Both the EGFR mutation-positive status and the use of a TKI are associated with higher incidence of brain metastases for patients with advanced non-squamous NSCLC. + + + + 28704781 + + + + + + + + 2018 + 5 + 12 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 12 + 12 + 10 + 0 + + + + + + + 18 + Targeted delivery of EGFR siRNA may be an effective strategy for the treatment of ovarian and other epithelial tumors. + + + + 27819259 + + + + + + + + 2018 + 5 + 12 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 12 + 11 + 51 + 0 + + + + + + + 18 + Surgical treatment is an effective approach for patients with synchronous multiple primary lung cancers (SMPLC). Mutational status of EGFR could be used as a diagnostic criterion, especially in patients with synchronous multiple primary lung adenocarcinomas (SMPLA) + + + + 28901318 + + + + + + + + 2018 + 5 + 12 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 12 + 11 + 15 + 0 + + + + + + + 18 + Gefitinib suppressed EGFR signaling. + + + + 27334428 + + + + + + + + 2018 + 5 + 12 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 12 + 10 + 53 + 0 + + + + + + + 18 + we also found that FGF8 increased the expression of YAP1 and knockdown of YAP1 eliminated the upregulation of EGFR and the resistance to EGFR inhibition induced by FGF8. Our study provides evidence that FGF8 plays an important role in the resistance to EGFR inhibition of human hepatocellular carcinoma cells + + + + 28791365 + + + + + + + + 2018 + 5 + 12 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 12 + 10 + 46 + 0 + + + + + + + 18 + Data suggest that dynamic changes in epidermal growth factor receptor (EGFR) activating (exon 19del and L858R) and resistance (T790M) mutation levels detected in urine could inform tumor response within days of therapy for advanced non-small cell lung cancer (NSCLC) patients receiving osimertinib, a second-line third-generation anti-EGFR tyrosine kinase inhibitor. + + + + 28420725 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 11 + 52 + 0 + + + + + + + 18 + In 19 patients treated with afatinib for >/=24 weeks, the number of EGFR mutant alleles detected in cfDNA by dPCR declined rapidly and markedly after treatment onset, becoming undetectable or detectable at only a low copy number (<10 copies per milliliter) at 4 weeks. + + + + 28177428 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 11 + 51 + 0 + + + + + + + 18 + EGFR expression is increased in oesophageal and gastric adenocarcinomas after neoadjuvant therapy but was not prognostic. + + + + 29138285 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 11 + 50 + 0 + + + + + + + 18 + Intratumor heterogeneity and the relatively low sensitivity of the ARMS contributed to discordant EGFRm status between TT specimens and ctDNA. + + + + 28552765 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 11 + 30 + 0 + + + + + + + 18 + Findings indicate that epidermal growth factor receptor variant III (EGFRvIII) mutation signature is potentially suitable for clinical translation. + + + + 28428190 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 47 + 0 + + + + + + + 18 + Signaling dissection using diverse inhibitors indicated that EOC cell proliferation driven by thyrostimulin-TSHR signaling is PKA independent, but does require the involvement of the MEK-ERK and PI3K-AKT signal cascades, which are activated mainly via the trans-activation of EGFR + + + + 27273257 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 45 + 0 + + + + + + + 18 + The abundance of EGFR mutations appeared to be more significantly associated with the copy number of EGFR mutations from circulating tumor DNA in 19DEL group. + + + + 28624467 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 44 + 0 + + + + + + + 18 + The concordance rate of EGFR gene copy number between primary tumors and recurring tumors was 65.9% (McNemar test: p = 0.510). + + + + 28854970 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 43 + 0 + + + + + + + 18 + The findings suggest that EGFR expression and gene copy number variation (CNV) are factors associated with poor prognosis, and that anticancer therapeutics against EGFR and HER2 receptors may be promising therapeutic options for patients with distal extrahepatic cholangiocarcinoma (EHCC). + + + + 28843919 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 41 + 0 + + + + + + + 18 + Patients with dual TP53/EGFR mutations, especially missense mutations, had marginally lower response rates and shorter PFS when treated with EGFR TKI therapy. + + + + 28838393 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 39 + 0 + + + + + + + 18 + EGFR T790M+ status was correlated to lower PD-L1 expression. PD-L1 expression might have a prognostic value and interaction with T790M mutation in EGFR-mutant NSCLC. + + + + 28838391 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 39 + 0 + + + + + + + 18 + Significant OS benefit was observed in patients with T790M mutation in lung cancer, suggesting that a larger proportion of T790M mutation might contribute to the better survival of patients with Del19. + + + + 28576746 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 29 + 0 + + + + + + + 18 + These results reveal a novel RTK-AKT-p300-ADA3 signaling pathway involved in growth factor-induced cell cycle progression. + + + + 28759294 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 16 + 0 + + + + + + + 18 + ShcD appears to possess several molecular permutations that actively govern the EGFR, which may have implications in development and disease. + + + + 28724758 + + + + + + + + 2018 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2018 + 5 + 5 + 10 + 5 + 0 + + + + + + + 18 + The aim of this study is to determine the prevalence of IDH mutations and EGFR amplifications in the population of the northeast region of Morocco and then to compare the results with other studies. + + + + 28785587 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 12 + 3 + 0 + + + + + + + 18 + Our data indicate that targeting IGFBP-3-dependent signaling pathways through gefitinib-FTY720 co-therapy may be effective in many basal-like breast cancers, and suggest tissue IGFBP-3 and CD44 measurement as potential biomarkers of treatment efficacy. + + + + 28778177 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 12 + 2 + 0 + + + + + + + 18 + It is a more exciting result that C20 was over 900 times more potent against HER-2 than against EGFR while this value was 0.19 for Erlotinib and 1.00 for Lapatinib, indicating high selectivity. + + + + 27273260 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 11 + 58 + 0 + + + + + + + 18 + Findings indicate that PIPKIgamma, functioning downstream of EGFR signaling, is critical to the progression of PDAC. + + + + 28388589 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 11 + 54 + 0 + + + + + + + 18 + clinical trials using ERBB2 (HER2) or EGFR as targets have not fully appreciated the molecular heterogeneity in which activated ERBB2 and EGFR systems operate. Proper tumor classification is likely to be critical for arriving at thorough conclusions regarding new HER2 and EGFR based treatment regimes. + + + + 28388586 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 11 + 54 + 0 + + + + + + + 18 + Results suggest that GALNT6 expression is associated with poor prognosis of ovarian cancer and enhances the aggressive behavior of ovarian cancer cells by regulating EGFR activity. + + + + 28388560 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 11 + 54 + 0 + + + + + + + 18 + Mutation oriented-LAMP assay for EGFR gene mutation is sensitive on extracted DNA. This procedure would be capable of detecting EGFR gene mutation in sputum, pleural effusion, broncho-alveolar lavage fluid or trans-bronchial lung biopsy by chair side. + + + + 29599327 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 11 + 43 + 0 + + + + + + + 18 + Data show that only ADP-ribosylation factor 1 (ARF1) promoter hypermethylation was significantly associated with epidermal growth factor receptor gene (EGFR) gene amplification in glioblastoma. + + + + 28631186 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 53 + 0 + + + + + + + 18 + HPV infection was significantly associated with amplification of both EGFR (76.5%) and cyclin D1 (73.0%). + + + + 28741068 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 49 + 0 + + + + + + + 18 + It is unclear if we may have seen greater clinical activity if we were able to fully inhibit Src in this study, but given the requirement that enrolling patients have documented disease progression on cetuximab, acquired resistant KRAS-mutant clones may have been present, limiting future strategies to reverse EGFR resistance + + + + 28280091 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 43 + 0 + + + + + + + 18 + This study demonstrated that IWBRT is efficacious with acceptable toxicity for patients with EGFR-mutant BMNSCLC among Chinese Han population. + + + + 29642161 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 39 + 0 + + + + + + + 18 + data suggested that EGFR mutation is one of the predictive factors for the development of brain metastasis in stages I-III non-small cell lung cancer + + + + 29447182 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 37 + 0 + + + + + + + 18 + The increased EGFR expression revealed in patients with seborrheic keratomas (SK)and concomitant (type 2 diabetes mellitus (DM2))is caused by insulin resistance and hyperinsulinemia, in which the dysregulation of insulin signal transmission into the cell leads to changes in EGF synthesis and signaling pathway that regulates cell proliferation and growth. + + + + 28791994 + + + + + + + + 2018 + 4 + 28 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 28 + 10 + 24 + 0 + + + + + + + 18 + A positive correlation among EGFR activation, SCD1 Y55 phosphorylation and SCD1 protein expression. + + + + 28724430 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 12 + 5 + 0 + + + + + + + 18 + Osimertinib provided clinical benefit with a manageable safety profile in patients with pretreated EGFR T790M mutation-positive NSCLC. + + + + 29363250 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 49 + 0 + + + + + + + 18 + In glioblastoma (GBM) cell lines, 5-aminolevulinic acid (5-ALA) induced fluorescence is variable and influenced by EGF-induced downstream activation of HO-1. HO-1 protein expression was identified as a negative regulator of 5-ALA induced fluorescence in GBM cells. Authors propose that co-expression of EGFRvIII but not quantitative EGFR expression influence HO-1 activity and therefore cellular fluorescence. + + + + 28500562 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 37 + 0 + + + + + + + 18 + Study found that miR-181b was decreased between paired initial and recurrent Glioblastoma multiforme (GBM) that were insensitive to Temozolomide (TMZ) treatment. Overexpression of miR-181b enhanced the chemo-sensitivity of GBM cells to TMZ by inducing cell apoptosis. Study demonstrated that EGFR, as a direct target of miR-181b, might be involved in the miR-181b-mediated chemo-resistance of GBM cells to TMZ. + + + + 28501897 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 37 + 0 + + + + + + + 18 + Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation. + + + + 28646091 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 11 + 0 + + + + + + + 18 + Exon 19 EGFRm achieved the best TKIs treatment outcome, while the optimal treatment of exon 18 and 20 mutations should be further clarified. + + + + 28427238 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 10 + 0 + + + + + + + 18 + The rate of detection of T790M mutation in patients with advanced NSCLC was approximately 63% and was unaffected by immediately prior treatment with an EGFR TKI or ethnicity. + + + + 28527899 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 11 + 9 + 0 + + + + + + + 18 + In summary, this investigation identifies an EGFR-DOCK180-RAC1-MLK3-JNK signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 emerges as a potential therapeutic target for the treatment of glioblastoma + + + + 28487380 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 10 + 21 + 0 + + + + + + + 18 + blocking EGFR signaling could be an efficacious strategy for breaking the interactions between cancer and bone cells in order to inhibit bone metastasis. + + + + 28758931 + + + + + + + + 2018 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 21 + 10 + 4 + 0 + + + + + + + 18 + Tissue microarray assays demonstrated a correlation between RHBDD1 and EGFR in colorectal cancer patients. Therefore, our findings indicate that RHBDD1 stimulates EGFR expression by promoting the AP-1 pathway. + + + + 28445956 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 12 + 3 + 0 + + + + + + + 18 + Elevated CEA levels during targeted therapy may be a more sensitive predictor of explosive lung adenocarcinoma progression in patients harboring mutant EGFRs compared to traditional imaging methods. + + + + 28705152 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 11 + 41 + 0 + + + + + + + 18 + Our results support the role of AMPK in EGFR signaling and drug sensitivity. + + + + 27279498 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 11 + 15 + 0 + + + + + + + 18 + Systematic mutation of the AREs (ARE1-3) in the LDLR 3'UTR and expression of each mutant coupled to a luciferase reporter in Huh7 cells demonstrated that ARE1 is required for rapid LDLR mRNA decay and 5-AzaC-induced mRNA stabilization via the IRE1alpha-EGFR-ERK1/2 signaling cascade. + + + + 29208426 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 11 + 11 + 0 + + + + + + + 18 + the EGFR G2607A polymorphism in exon 20 is frequent in bladder cancer cases and must be further explored for its relevance in the treatment of this disease. + + + + 28719349 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 10 + 38 + 0 + + + + + + + 18 + Patients with epidermal growth factor receptor (EGFR) exon 19 mutation had a higher overall survival than those harboring EGFR exon 21 mutation. + + + + 28380449 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 10 + 19 + 0 + + + + + + + 18 + Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 and subsequent activation of EGFR and RAF1 oncogenes + + + + 28174233 + + + + + + + + 2018 + 4 + 14 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 14 + 10 + 4 + 0 + + + + + + + 18 + Determined rate of occurence EGFR subtype mutations and demonstrated that different mutations showed different clinicopathological manifestations in lung cancer. + + + + 28554755 + + + + + + + + 2018 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 7 + 11 + 44 + 0 + + + + + + + 18 + AFR3 cells harbored the secondary EGFR mutation T790M. Our findings constitute the first report showing acquired wild-type KRAS overexpression and attenuation of afatinib resistance following a drug holiday. The heterogeneous mechanisms of afatinib resistance should facilitate the development of more effective therapeutic strategies for non-small cell lung cancer patients + + + + 28289161 + + + + + + + + 2018 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 7 + 11 + 37 + 0 + + + + + + + 18 + High expression of EGFR is associated with gastric cancer. + + + + 28535014 + + + + + + + + 2018 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 7 + 10 + 55 + 0 + + + + + + + 18 + High expression of EGFR is associated with hepatocellular carcinoma. + + + + 28586051 + + + + + + + + 2018 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 7 + 10 + 17 + 0 + + + + + + + 18 + EGFR and CK5/6 expression could serve as biomarkers for identifying triple-negative breast cancer patients with poor survival + + + + 28648939 + + + + + + + + 2018 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2018 + 4 + 7 + 10 + 12 + 0 + + + + + + + 18 + we found that almost all T790M mutations are present in cis with activating mutations regardless of whether tumor resistance to first-generation EGFR-TKIs caused by T790M is intrinsic or acquired. Cancer cells with T790M in cis with an activating mutation thus appear to be selected and enriched during treatment with EGFR-TKIs. + + + + 28625653 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 12 + 5 + 0 + + + + + + + 18 + The main pattern of progression in mEGFRmt NSCLC on erlotinib is in the initial sites of disease. Younger patients and those without brain involvement are particularly likely to develop ISF. This suggests a role for incorporating local therapy into treatment of selected patients with mEGFRmt NSCLC. + + + + 28625621 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 12 + 5 + 0 + + + + + + + 18 + the exact prevalence of EGFR mutations in different countries and non-small cell lung cancer patient subgroups (Meta-Analysis) + + + + 27738317 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 11 + 24 + 0 + + + + + + + 18 + All cell lines showed similar response to both drug and siRNA inhibition of both PI3K and mTORC pathways, with anti-EGFR combination producing modest additive effect. Five PDX models that presented PIK3CA mutation or intrinsic cetuximab resistance were treated with a combination of cetuximab and AZD8055 + + + + 28446642 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 11 + 15 + 0 + + + + + + + 18 + EGFR protein expression is regulated by miR-370 and the miR-370-EGFR pathway is involved in the process of cell growth and migration in gastric cancer. + + + + 28534999 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 10 + 9 + 0 + + + + + + + 18 + EGFR expression is associated not only with amplification, but also with chromosome 7 centromere multiple copies. Chromosome 7 multiplication -due to centromere region amplification or true polysomy- is critical for applying monoclonal antibody targeted therapeutic strategies excluding the pure non-amplified cases. + + + + 28652432 + + + + + + + + 2018 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 31 + 10 + 4 + 0 + + + + + + + 18 + Cy-3-glu directly binds to the ligand-binding domain (LBD) of ERalpha36, inhibits EGFR/AKT signaling, and promotes EGFR degradation + + + + 27655695 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 12 + 17 + 0 + + + + + + + 18 + loss of Llgl1 results in EGFR mislocalization, promoting pre-neoplastic changes + + + + 27542214 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 12 + 1 + 0 + + + + + + + 18 + Study reveals the incidence of EGFR mutations in Chinese patients with lung adenocarcinoma to be 40.7%. Smoking history, tumor differentiation, and acinar predominant and mucinous subtypes were independent predictors of EGFR mutation. + + + + 28940943 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 11 + 48 + 0 + + + + + + + 18 + matched-pair and multi-institutional analysis reveals that an EGFR mutation was not a significant risk factor for recurrence of patients with surgically resected lung adenocarcinoma + + + + 29173761 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 11 + 20 + 0 + + + + + + + 18 + These findings indicate the importance of developing HDAC3-selective inhibitors, and their combined use with osimertinib, for treating EGFR-mutated lung cancers carrying the BIM deletion polymorphism + + + + 27986747 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 11 + 18 + 0 + + + + + + + 18 + EGFR gene amplification and KRAS mutations are predictive markers for patients receiving combination biologic therapy. + + + + 28025786 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 10 + 54 + 0 + + + + + + + 18 + the EGFR-USP8-trichoplein-Aurora A axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation + + + + 29472535 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 10 + 35 + 0 + + + + + + + 18 + Data demonstrated that EGFR plays a pivot role in diabetic nephropathy pathogenesis via upregulating oxygen species generation and ER stress. + + + + 28427241 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 10 + 16 + 0 + + + + + + + 18 + in non-small cell lung cancer patients, mutations in EGFR were associated with a higher rate of miliary brain and lung metastases + + + + 28521651 + + + + + + + + 2018 + 3 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 24 + 10 + 9 + 0 + + + + + + + 18 + 2D-QSAR and 3D-QSAR Analyses for EGFR Inhibitors. + + + + 28630865 + + + + + + + + 2018 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 17 + 11 + 19 + 0 + + + + + + + 18 + The mutation rate of EGFR in stag I-IIIa NSCLC patients was lower than that in advanced NSCLC patients. And the percentage of the NSCLC patients with EGFR-KRAS double mutations is 0.9%. + + + + 28935015 + + + + + + + + 2018 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 17 + 10 + 48 + 0 + + + + + + + 18 + The incidence of EGFR mutation in this cohort of NSCLC is 9% which is consistent with mutation incidence reported in other countries. + + + + 28185061 + + + + + + + + 2018 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 17 + 10 + 47 + 0 + + + + + + + 18 + EGFR mutations in non-small cell lung cancer and their role in the resistance to tyrosine kinase inhibitors + + + + 28573640 + + + + + + + + 2018 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 17 + 10 + 19 + 0 + + + + + + + 18 + EGFR mutation status was not a prognostic indicator after surgery in early-stage lung adenocarcinoma + + + + 28577949 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 12 + 5 + 0 + + + + + + + 18 + mutated plasma EGFR concentration correlated with tumor burden + + + + 28577941 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 12 + 5 + 0 + + + + + + + 18 + This study suggested that EGFR was an important predictive factor for the prognosis of the post-operative patients with colorectal carcinoma TNM stage I-II, and nm23 is important for predicting the prognosis of the patients with stage III-IV; it is better that EGFR and nm23 are as predictor of combination. + + + + 27888614 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 12 + 3 + 0 + + + + + + + 18 + EGFR mutations were found in 88% of Sinonasal Inverted Papillomas and 77% of Sinonasal Inverted Papilloma associated Sinonasal Squamous Cell Carcinoma. + + + + 28432463 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 59 + 0 + + + + + + + 18 + advanced non-small-cell lung cancer bearing the EGFR exon 19 insertion or exon 20 insertion is sensitive to EGFR tyrosine kinase inhibitors + + + + 28089594 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 39 + 0 + + + + + + + 18 + optimized an ultrafast laser photolysis hydroxyl radical footprinting method and applied it to study the interaction of EGF and EGFR in live mammalian cells. + + + + 28452222 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 29 + 0 + + + + + + + 18 + This suggests that these compounds may be affected by the EGFR mutation. In conclusion, the present study identified four potential biomarkers in patients with EGFR mutations, using HRM combined with pathway analysis. These results may facilitate the development of novel diagnostic tools for EGFR mutation detection in patients with lung cancer. + + + + 28487968 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 29 + 0 + + + + + + + 18 + thrombin binding to PAR-1 receptor activated Gi-protein/c-Src/Pyk2/EGFR/PI3K/Akt/p42/p44 MAPK cascade, which in turn elicited AP-1 activation and ultimately evoked MMP-9 expression and cell migration in SK-N-SH cells. + + + + 27181591 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 5 + 0 + + + + + + + 18 + EGFR mutations were confirmed in every case of 16 Asian lung adenocarcinomas (LUAD) regardless of the mutation type. + + + + 29335443 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 11 + 2 + 0 + + + + + + + 18 + These results implicate EGFR as a key regulator of RET activation in A+AD and suggest that EGFR inhibitors may be therapeutic in patients with A+AD tumors even in the absence of an EGFR or RET mutation. + + + + 28460442 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 10 + 52 + 0 + + + + + + + 18 + NSCLC patients with EGFR mutations showed significantly lower MTV than patients with wild-type EGFR. Prediction models based on MTV and clinicopathologic characteristics could provide more information for the identification of EGFR mutations. + + + + 28422710 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 10 + 44 + 0 + + + + + + + 18 + No overall survival difference was found between patients with single EGFR mutation and concurrent gene alterations. We demonstrated that concurrent gene alterations occurred in some patients with EGFR mutations. Concurrent gene alterations decreased the efficacy of EGFR-TKIs. + + + + 28212572 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 10 + 41 + 0 + + + + + + + 18 + Our findings indicated that compared with EGFR wild type patients, EGFR mutant patients have better ORRs and DCRs after icotinib treatment; EGFR 19Del patients treated with icotinib have better ORRs than EGFR L858R patients. EGFR mutation status is a useful biomarker for the evaluation of icotinib efficacy in NSCLC patients. + + + + 28430623 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 10 + 30 + 0 + + + + + + + 18 + EGFR mutations in ctDNA predicted a better PFS, in particular in advanced NSCLC patients treated by EGFR-TKIs. + + + + 28430611 + + + + + + + + 2018 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 10 + 10 + 30 + 0 + + + + + + + 18 + Data analyze ouycomes of patients with advanced non-small cell lung cancer (NSCLC) and EGFR active mutation. + + + + 27655708 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 12 + 5 + 0 + + + + + + + 18 + Our findings suggest that Akt2 might be associated with the resistance to anti-EGFR therapies, especially the use of erlotinib against PC, and that this resistance can be overcome by combined treatment with a PI3K inhibitor. Akt2 expression could become a predictive biomarker for erlotinib resistance in PC. + + + + 28440469 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 12 + 4 + 0 + + + + + + + 18 + microRNA expression profiles had clinicopathological implications that were related to EGFR and KRAS mutations, as well as ALK-rearrangement in lung adenocarcinoma. + + + + 28035073 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 11 + 54 + 0 + + + + + + + 18 + The relative expression of wtEGFR and its competing ligands could serve as a more reliable predictive biomarker of response to therapy with anti-EGFR mAbs in metastatic colorectal cancer. + + + + 28032593 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 11 + 53 + 0 + + + + + + + 18 + These results suggest that HBEGF is an important EGFR ligand in cervical cancer and that cervical cancer cells are the predominant source of HBEGF. Therefore, we propose an autocrine EGFR stimulation model in cervical carcinomas. + + + + 28498437 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 11 + 51 + 0 + + + + + + + 18 + These data imply the potential clinical application of EGF-LDP-IGF-AE for esophageal squamous cell carcinoma (ESCC)patients with EGFR and/or IGF-1R overexpression + + + + 28498434 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 11 + 51 + 0 + + + + + + + 18 + Kindlin-2 is up-regulated in glioma cells and acts as an oncogene. It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1/beta-catenin complex promotes EGFR transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 may be a novel strategy for glioma treatment. + + + + 27713156 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 11 + 48 + 0 + + + + + + + 18 + High dose icotinib plus sequential docetaxel has an additive effect on suppressing the growth of wild-type EGFR non-small cell lung cancer cell nude mouse xenografts, possibly through microvessel density reduction. + + + + 27852073 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 10 + 55 + 0 + + + + + + + 18 + EGFR mutation is associated with treatment response in non-small-cell lung cancer. + + + + 28945865 + + + + + + + + 2018 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 3 + 3 + 10 + 11 + 0 + + + + + + + 18 + EGFR pathway gene expression analysis indicated that DeltaNp63 alters EGFR-regulated genes involved in cell adhesion, migration, and angiogenesis. Addition of EGF or neutralizing EGFR antibodies demonstrated that EGFR activation is responsible for DeltaNp63-mediated loss of cellular adhesion + + + + 28349272 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 45 + 0 + + + + + + + 18 + the nuclear EGFR activates PRKDC/PNPase/MYC signaling to inhibit autophagy. Although the role of mitochondria-located EGFR in autophagy is largely unexplored, the production of ATP and reactive oxygen species mediated by mitochondrial dynamics is most likely to influence autophagy + + + + 28428083 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 40 + 0 + + + + + + + 18 + EGFR monoclonal antibody may sensitize cancer stem cell-like colorectal cells to 5-FU-induced apoptosis by affecting autophagy. + + + + 27833077 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 36 + 0 + + + + + + + 18 + EGFR point mutations are associated lung cancer. + + + + 26992209 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 36 + 0 + + + + + + + 18 + We report on the impact of bispecific targeting on the toxicity risks associated with targeting of EGFR and uPAR . Our results show that eBAT is safe and potentially effective at biologically active doses despite EGFR targeting, supporting further translation for patients with sarcomas and other EGFR-expressing malignancies. + + + + 28193671 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 35 + 0 + + + + + + + 18 + Consequently, the application of metformin for T2D small cell lung cancer patients receiving chemo or EGFR targeted therapy should be considered with caution + + + + 28391030 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 32 + 0 + + + + + + + 18 + RAS mutations and HER2/MET amplification were the most frequently detected resistance mechanisms in both tissue and blood sample analysis. On the other hand, BRAF and EGFR ectodomain mutations were much rarer.The combined analysis of tissue and blood (ctDNA) results highlights the complexity of clonal evolution triggered by EGFR blockade + + + + 27780856 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 17 + 0 + + + + + + + 18 + TP53 mutations, especially exon 8 mutations, reduce responsiveness to TKIs and worsen prognosis in EGFR-mutated NSCLC patients, mainly those carrying exon 19 deletions. + + + + 27780855 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 17 + 0 + + + + + + + 18 + Report unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous non small cell lung cancers. + + + + 28060728 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 15 + 0 + + + + + + + 18 + These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha signalling and activation of EGFR. + + + + 28412413 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 9 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutant III (EGFRvIII) is exclusively expressed in tumors. Small animal SPECT/CT imaging revealed that radiolabeled novel mAb 4G1 could be used for imaging EGFRvIII expression in preclinical glioblastoma xenografts. + + + + 28031526 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 11 + 8 + 0 + + + + + + + 18 + Our data show that Time to neurological progression can be effectively extended in preexisting brain metastases patients with EGFR-sensitizing mutations initially treated with erlotinib compared with gefitinib. If confirmed, our results indicate that erlotinib may play an important role in controlling CNS progression from EGFR mutation-positive non-small cell lung cancer . + + + + 28376735 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 58 + 0 + + + + + + + 18 + Studied epidermal growth factor receptor (EGFR) expression's prognostic value for predicting overall and disease-free survival in locally advanced head and neck squamous cell carcinoma. + + + + 28452036 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 46 + 0 + + + + + + + 18 + PHD2 is a direct binding partner of EGFR and show that PHD2 regulates EGFR stability as well as its subsequent signaling in breast carcinoma cells. + + + + 28038470 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 37 + 0 + + + + + + + 18 + Confirmation of clinical benefit will be through the ongoing randomized trial of osimertinib versus standard therapy in patients with metastatic Non-Small Cell Lung Cancer whose disease has progressed with previous EGFR TKI and whose tumors harbor an EGFR T790M mutation + + + + 27923840 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 37 + 0 + + + + + + + 18 + Data show that first-line EGFR tyrosine kinase inhibitor (TKI) therapy provided longer progression-free survival (PFS) than did second-line EGFR TKI therapy. + + + + 27637087 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 36 + 0 + + + + + + + 18 + EGFR mutation is an independent predictive and prognostic risk factor for brain metastasis and a positive predictive factor for overall survival in patients with brain metastasis + + + + 27486770 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 36 + 0 + + + + + + + 18 + Nestin promotes neural progenitor cells (NPCs) proliferation via p38-MAPK and EGFR pathways, and reveals the necessity of these pathways in NPCs self-renewal. + + + + 27894083 + + + + + + + + 2018 + 2 + 24 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 24 + 10 + 23 + 0 + + + + + + + 18 + cervical cancer specimens and cell lines, expression of Cx32 upregulated epidermal growth factor receptor (EGFR) expression. Inhibition of EGFR signaling abrogated the anti-apoptotic effect of Cx32 expression. + + + + 28492539 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 44 + 0 + + + + + + + 18 + Combined CT and clinical features may be helpful for determining the presence of EGFR mutations in patients with small peripheral lung adenocarcinoma, particularly in patients where mutational profiling is not available or possible. + + + + 28383802 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 43 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor Mutation is associated with response to therapy in Non-small Cell Lung Cancer. + + + + 26887852 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 36 + 0 + + + + + + + 18 + Patients with exon 19 mutations obtained greater benefits from targeted therapy. In the new classification, EGFR mutation rates are higher in lepidic cases and in cases without the solid subtype. The micropapillary subtype of adenocarcinoma has the worst prognosis, while the lepidic subtype has the best + + + + 28220630 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 33 + 0 + + + + + + + 18 + We conclude that KGF-KGFR activates Akt-mTORC1 downstream Nrf2 signaling to protect RPE cells from UV radiation. + + + + 29253569 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 19 + 0 + + + + + + + 18 + High EGFR expression is associated with Chromosomal Instability in Gastric Cancer. + + + + 26847684 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 14 + 0 + + + + + + + 18 + The present study demonstrated that pathological stage I adenocarcinoma harboring EGFR and K-ras gene mutations have distinct clinicopathological features. The presence of these mutations alone were not prognostic factors in patients with resected pathological stage I adenocarcinoma. + + + + 28322512 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 11 + 14 + 0 + + + + + + + 18 + Data suggest that agents that degrade L858R/T790M-EGFR protein may overcome tyrosine kinase inhibitors (TKIs) resistance. + + + + 27612423 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 56 + 0 + + + + + + + 18 + EGFR Mutation is associated with Lung cancer. + + + + 27339415 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 53 + 0 + + + + + + + 18 + Increased ETS exposure was closely associated with EGFR mutations in female never-smokers with NSCLC in the expanded multinational cohort. However, the association of ETS and ALK rearrangements in never-smokers with NSCLC was not significant. + + + + 28433570 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 49 + 0 + + + + + + + 18 + Data shows that EGFR expression is under the regulation of EHD3,as well as its activation, ubiquitination, signaling and signal attenuation upon ligand stimulation. + + + + 27811356 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 47 + 0 + + + + + + + 18 + Case Report: multiple primary lung cancer displaying heterogeneous EGFR and PTEN molecular profiles. The right lung lesion displayed gefitinib-insensitivity and the lesions in the left lung were gefitinib-sensitive. + + + + 27823967 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 34 + 0 + + + + + + + 18 + Report early adaptive drug-escape in EGFR-mutant lung tumor cells dependent on TGFbeta2-bioenergetics-mitochondrial priming. + + + + 27852038 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 9 + 0 + + + + + + + 18 + EGFR mutation is associated with treatment response in lung cancer. + + + + 27079185 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 7 + 0 + + + + + + + 18 + EGFR exon 21 point mutations are an independent high-risk factor for developing brain metastasis during the course of EGFR-TKIs therapy for patients with EGFR-mutated advanced lung adenocarcinoma. + + + + 27626317 + + + + + + + + 2018 + 2 + 17 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 17 + 10 + 5 + 0 + + + + + + + 18 + EGFR gene amplification and mutations are rare in triple-negative breast cancer (TNBC), the latter of no apparent clinical relevance. Surrogate markers of EGFR-related chromosomal aberrations and combined EGFR/p53 IHC phenotypes appear to be associated with favorable prognosis in patients with operable TNBC receiving conventional adjuvant chemotherapy. + + + + 28446533 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 11 + 55 + 0 + + + + + + + 18 + EGFR gene copy number is a biomarker for response to EGFR-tyrosine kinase inhibitor therapy in patients with advanced non-small-cell lung cancer. + + + + 27664271 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 11 + 40 + 0 + + + + + + + 18 + Osimertinib reduces PD-L1 mRNA expression and induces its protein degradation, suggesting that osimertinib may reactivate the immune activity of T cells in the tumor microenvironment in EGFR-mutated NSCLC patients. + + + + 28880013 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 11 + 10 + 0 + + + + + + + 18 + There is a higher incidence of brain metastases for patients with EGFR+ metastatic non-small cell lung cancer, even when adjusted for differences in survival, compared to EGFR wild type. + + + + 27133758 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 11 + 8 + 0 + + + + + + + 18 + EGFR expression was associated with shorter cancer-specific overall survival. Our finding suggests EGFR is a useful prognostic marker of patients with distal extrahepatic bile duct (EBD) carcinoma. + + + + 27020207 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 47 + 0 + + + + + + + 18 + MET/T790M-positive patients are at higher risk of acquired resistance to EGFR-Tyrosine kinase inhibitors, and have a worse Post-progression survival than patients with only MET overexpression or the T790M mutation alone. Clinical trials are needed to determine the best treatment for patients with both MET overexpression and the EGFR T790M mutation. + + + + 27259997 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 45 + 0 + + + + + + + 18 + the EGFR/STAT3 pathway contributed to CDDP-induced CEBPD expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel + + + + 27435393 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 44 + 0 + + + + + + + 18 + EGFR rs11506105 is strongly associated with treatment responses in Iranian patients with chronic hepatitis C. + + + + 28703131 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 34 + 0 + + + + + + + 18 + EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. + + + + 27244890 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 33 + 0 + + + + + + + 18 + The long noncoding RNA CAR intergenic 10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1), leading to up-regulation of the epidermal growth factor receptor (EGFR) and proliferation of lung cancer cells. + + + + 27322209 + + + + + + + + 2018 + 2 + 10 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 10 + 10 + 29 + 0 + + + + + + + 18 + Findings indicate the importance of Src-Stat3 signaling cascade in gallic acid (GA)-mediated tumor-suppression activity and a therapeutic insight of GA for acquired resistance to EGF receptor tyrosine kinase inhibitors in lung cancer. + + + + 27419630 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 54 + 0 + + + + + + + 18 + EGFR mutation status was strongly associated with smoking status, especially smoking index. + + + + 29049789 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 51 + 0 + + + + + + + 18 + Data suggest that Dsg2 stimulates cell growth and migration by positively regulating EGFR level and signaling through a c-Src and Cav1-dependent mechanism using lipid rafts as signal modulatory platforms. + + + + 26918609 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 49 + 0 + + + + + + + 18 + T790M-negative patients with EGFR mutation-positive non-small cell lung carcinomas are more likely to benefit from nivolumab after EGFR-TKI treatment, possibly as a result of a higher PD-L1 expression level, than are T790M-positive patients. + + + + 28407039 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 45 + 0 + + + + + + + 18 + Data show that IL-17E, similarly to EGF, activates the epidermal growth factor receptor (EGFR) in triple-negative breast cancers (TNBCs) cells that are resistant to EGFR inhibitors. + + + + 27462789 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 45 + 0 + + + + + + + 18 + Data suggest that findings may hint at the direction of future research into lung carcinogenesis and epidermal growth factor receptor (EGFR) mutagenesis. + + + + 27449093 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 42 + 0 + + + + + + + 18 + Data suggest that analysis of mutant epidermal growth factor receptor (EGFR) expression might predict the efficacy of tyrosine kinase inhibitors (TKIs) treatment for non-small cell lung cancer (NSCLC) patients harboring sensitive EGFR mutation. + + + + 27418143 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 11 + 27 + 0 + + + + + + + 18 + Data suggest that the scFv isolated can be the groundwork for developing more effective diagnostic and therapeutic agents against mutant form of epidermal growth factor receptor (EGFRvIII) expressing cancers. + + + + 27984065 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 51 + 0 + + + + + + + 18 + These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations. + + + + 27401248 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 51 + 0 + + + + + + + 18 + The anti-EGFR viroplexes with IL-12 and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin. + + + + 27191929 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 36 + 0 + + + + + + + 18 + While the EGFR mutation rate was lower in the younger group (52.5% versus 60.6%, P = 0.001), the primary site of lung cancer and stage distribution were not significantly different. + + + + 27191886 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 36 + 0 + + + + + + + 18 + Data show that MET amplification identified by circulating-free DNA (cfDNA) occurred in a sizable subset of patients that are refractory to anti-EGFR therapy. + + + + 27421137 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 18 + 0 + + + + + + + 18 + Simulation results indicate that human epidermal growth factor receptor (hEGFR) soluble soluble extracellular domains (sECD):EGF show different dynamic properties between the two pHs, and the complex may have a higher tendency of activation at pH 8.5. + + + + 27179806 + + + + + + + + 2018 + 2 + 3 + 10 + 2 + 0 + + + + + + + + + 2018 + 2 + 3 + 10 + 10 + 0 + + + + + + + 18 + RTN3 was critical for EGFR-nonclathrin endocytosis (NCE), promoting the creation of plasma membrane - endoplasmic reticulum contact sites that were required for the formation and/or maturation of NCE invaginations. + + + + 28495747 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 12 + 7 + 0 + + + + + + + 18 + hPEPD-G278D is a dual inhibitor of ErbB1 and ErbB2 and selectively targets cancer cells overexpressing ErbB1 and/or ErbB2 + + + + 27286447 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 11 + 48 + 0 + + + + + + + 18 + High EGFR expression is associated with prostate cancer. + + + + 28986450 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 11 + 20 + 0 + + + + + + + 18 + Osimertinib is designed to bind covalently to a cysteine Residue of EGFR and is extensively distributed and metabolized and is eliminated primarily via the fecal route. + + + + 27226351 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 11 + 17 + 0 + + + + + + + 18 + Oral squamous cell carcinoma (OSCC) with abnormal EGFR gene copy number were more likely to undergo malignant transformation than diploid cases. EGFR genomic gain was detected in a quarter of early-stage OSCC, but did not correlate with clinical outcomes. + + + + 27197272 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 11 + 16 + 0 + + + + + + + 18 + High EGFR expression is associated with lung cancer. + + + + 26956044 + + + + + + + + 2018 + 1 + 27 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 27 + 10 + 38 + 0 + + + + + + + 18 + EGFR gene mutations were detected in 28.6% (8/28) and 42.9% (12/28) of the samples. + + + + 29097164 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 12 + 3 + 0 + + + + + + + 18 + The high expression of EGFR in head and neck cancers among Pakistani patients suggests its value as a therapeutic target. EGFR inhibitors have become well-known part of HNSCC treatment; therefore, patients with EGFR positive HNSCC can be benefitted from the therapy. + + + + 28492148 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 11 + 55 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) signaling enhances miR-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1 + + + + 27477273 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 11 + 21 + 0 + + + + + + + 18 + PAK1 confers TKI resistance in EGFR-mutant cells as well as in EGFR-wild-type cells. + + + + 27178741 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 11 + 15 + 0 + + + + + + + 18 + large scale studies comprehending different populations are needed to evaluate the impact of genome variants on breast cancer outcomes + + + + 29267323 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 11 + 10 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor (EGFR), a protein that is overexpressed and highly activated in multiple cancers, can be directly inhibited by Static Magnetic Fields (SMFs). Using Liquid-phase Scanning Tunneling Microscopy (STM) to examine pure EGFR kinase domain proteins at the single molecule level in solution, we observed orientation changes of these proteins in response to SMFs. + + + + 27223425 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 11 + 0 + 0 + + + + + + + 18 + This correlated with increased EGFR-specific cytotoxic CD8(+) T cells. + + + + 27217441 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 10 + 54 + 0 + + + + + + + 18 + Studied iNOS(inducible nitric oxide synthase) activation thru mPGES-1 (microsomal prostaglandin E synthase-1) signaling driven by EGFR (EGF receptor) in cancer progression models. + + + + 28257996 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 10 + 27 + 0 + + + + + + + 18 + Data indicate the interrelated networks of genes and miRNAs whose expression was different between del19 and L858R of epidermal growth factor receptor (EGFR) mutations. + + + + 27463019 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 10 + 11 + 0 + + + + + + + 18 + miR-875-5p played a pivotal role in colorectal carcinoma through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic EGFR + + + + 27302926 + + + + + + + + 2018 + 1 + 20 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 20 + 10 + 5 + 0 + + + + + + + 18 + Leptomeningeal metastases were much more frequent in patients with non-small cell lung cancer harboring EGFR mutations + + + + 27539328 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 14 + 44 + 0 + + + + + + + 18 + Epidermal growth factor (EGF) stimulates H2O2 production in a calcium-dependent way.Downregulation of Duox1 or DuoxA1 expression abolishes the EGF-evoked H2O2 production. + + + + 27262981 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 14 + 33 + 0 + + + + + + + 18 + A drop in plasma-mutant EGFR levels to </=10 molecules/mL was seen by day 21 of treatment in 7 of 8 patients with documented partial response. + + + + 26747242 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 13 + 55 + 0 + + + + + + + 18 + Combined EGFR and ROCK inhibition effectively blocks proliferation of triple-negative breast cancer (TNBC) cells. + + + + 27374095 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 13 + 51 + 0 + + + + + + + 18 + The combined biomarkers E-cadherin, membranous epidermal growth factor receptor (EGFR) and vimentin show a stronger prognostic value for and disease-free survival than any of the single biomarkers. + + + + 27172790 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 12 + 58 + 0 + + + + + + + 18 + NSCLCs harboring EGFR mutations or ALK rearrangements are associated with low ORRs to PD-1/PD-L1 inhibitors. Low rates of concurrent PD-L1 expression and CD8(+) TILs within the tumor microenvironment may underlie these clinical observations. + + + + 27225694 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 12 + 54 + 0 + + + + + + + 18 + this study is the first to show that a membrane-located tyrosine kinase receptor, such as EGFR, is internalized to a nuclear/perinuclear location upon exposure to stress and modulates the stability and translation of miRNA-selected mRNAs. + + + + 29253018 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 12 + 44 + 0 + + + + + + + 18 + Noninvasive assays for evaluation of acquired resistance to first-line EGFR TKIs. + + + + 27281561 + + + + + + + + 2018 + 1 + 13 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 13 + 12 + 37 + 0 + + + + + + + 18 + Induced by former systemic therapy, there were more T790M (18%), concomitant EGFR mutations (15%), and changes to EGFR wild type (19%) in the MR group among patients with EGFR mutations, which indicated higher incidence of genetic heterogeneity + + + + 28126915 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 11 + 44 + 0 + + + + + + + 18 + This article explains the options available after progression on initial EGFR TKI therapy and the importance of molecular testing at progression in making making treatment decisions + + + + 27821794 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 11 + 33 + 0 + + + + + + + 18 + findings demonstrated that the combination of carmustine and selenite treatment dramatically inhibits EGFR signaling, proliferation, and induces apoptosis in Androgen-Independent Prostate Cancer cells + + + + 28430389 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 11 + 26 + 0 + + + + + + + 18 + the results of this study highlight an important role for miR-218-5p in the regulation of epidermal growth factor receptor in non-small cell lung cancer + + + + 27057632 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 11 + 18 + 0 + + + + + + + 18 + ErbB receptors and tetraspanins: Casting the net wider + + + + 27262234 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 10 + 24 + 0 + + + + + + + 18 + findings suggest that the potency of first-generation inhibitors to prevent EGFR signaling is reduced in the setting of the L858M/L861Q mutation. + + + + 28088511 + + + + + + + + 2018 + 1 + 6 + 10 + 2 + 0 + + + + + + + + + 2018 + 1 + 6 + 10 + 3 + 0 + + + + + + + 18 + Results show a significant over-expression of EGFR and IGF1R in adrenocortical carcinoma (ACC) tissue. + + + + 27105537 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 13 + 2 + 0 + + + + + + + 18 + Adding bevacizumab increased toxicity without apparent improvement in efficacy, countering the hypothesis that dual EGFR-VEGF targeting would overcome radiation resistance, and enhance clinical benefit. + + + + 27177865 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 54 + 0 + + + + + + + 18 + The tumors of never-smokers were more often poorly differentiated and more often contained oncogenic mutations particularly EGFR mutation. + + + + 27092882 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 54 + 0 + + + + + + + 18 + MUC1-driven EGFR expression and signaling regulates proliferation of endometrial cancer cells. + + + + 27092881 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 54 + 0 + + + + + + + 18 + In line with SQUIRE ITT, addition of necitumumab to gemcitabine-cisplatin significantly prolonged OS and was generally well tolerated in the subpopulation of patients with EGFR-expressing advanced squamous non-small-cell lung cancer. The benefit from addition of necitumumab to chemotherapy was not apparent in this analysis for the small subgroup of patients with non-EGFR-expressing tumors + + + + 27207107 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 21 + 0 + + + + + + + 18 + Shikonin remarkably suppressed the phosphorylation of EGFR and led to EGFR degradation. + + + + 27864022 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 14 + 0 + + + + + + + 18 + Erlotinib in first-line treatment of metastatic non-small cell lung cancer in patients who present activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor showed similar results compared with other clinical trials in Caucasian patients + + + + 27162148 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 12 + 9 + 0 + + + + + + + 18 + Patients were randomized (2:1) to oral afatinib 40 mg/day or up to six cycles of cisplatin-based chemotherapy stratified by EGFR mutation type (Del19/L858R/other) and race (Asian/non-Asian; LL3 only) + + + + 27601237 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 11 + 45 + 0 + + + + + + + 18 + Data show that TAZ, a WW-domain-containing transcriptional co-activator, could promote the acceleration of cell cycle and cell proliferation through EGFR pathway. + + + + 27167112 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 11 + 17 + 0 + + + + + + + 18 + These results suggest that Cav-1 may be a predictor of the poor efficacy of EGFR-TKIs treatment in lung adenocarcinoma with EGFR mutations. + + + + 29137977 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 11 + 4 + 0 + + + + + + + 18 + Studies indicate the role of tyrosine kinase inhibitors (TKIs) in EGFR non-mutated non-small-cell lung cancer (NSCLC) patients. + + + + 26993607 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 10 + 49 + 0 + + + + + + + 18 + The combination of EGFR-TKI and anti-IL-6 antibody moderately improved the sensitivity of EGFR-TKI in lung cancer cell with EGFR mutation. Interestingly, suppression of EGFR with EGFR-TKI accelerated the activation of STAT3 induced by IL-6. Taken together, tumour IL-6 levels might indicate a subpopulation of EGFR-mutant NSCLC that benefits less from gefitinib monotherapy. + + + + 29101033 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 10 + 44 + 0 + + + + + + + 18 + These results indicated that miR-133a could inhibit the MEK/ERK pathway to promote cell apoptosis and enhance radio-sensitivity by targeting EGFR in Esophageal Cancer. + + + + 27933650 + + + + + + + + 2017 + 12 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 30 + 10 + 3 + 0 + + + + + + + 18 + Data (including data from studies using transgenic/knockout mice) suggest that surfactant protein A1 (SPA1) interferes with EGF binding to EGFR in pulmonary alveoli cell lines; SPA1 directly binds extracellular domain of EGFR; binding of SPA1 to EGFR appears to be different from binding of SPD to EGFR; binding of SPA1 to EGFR does not suppress EGF-induced phosphorylation of EGFR or cell proliferation. + + + + 28972165 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 12 + 56 + 0 + + + + + + + 18 + Describe neoplastic behavior glioblastoma cell line expressing EGFRvIII. + + + + 27004406 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 12 + 33 + 0 + + + + + + + 18 + Findings suggest that sEGFR might be a biomarker for evaluating insulin resistance or a therapeutic target of liraglutide. + + + + 29028997 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 12 + 17 + 0 + + + + + + + 18 + Temporal monitoring of the EGFR T790M and the activating EGFR mutation in cfDNA offers an alternative method to radiological imaging for evaluating response and early resistance development in patients treated with AZ9291. + + + + 27393503 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 12 + 7 + 0 + + + + + + + 18 + Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR expression. + + + + 28544031 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 12 + 3 + 0 + + + + + + + 18 + Results show that EGFR is involved in PIK3CA promoting the progression of gallbladder carcinoma through its enhanced binding to PIK3CA. + + + + 27317099 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 11 + 50 + 0 + + + + + + + 18 + Results show that EGFR is frequently mutated and activated in human lung cancers and that DDX59 mediates its activity. + + + + 29133145 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 11 + 48 + 0 + + + + + + + 18 + EGFR mutation must be investigated in HIV-NSCLC cases due to its predictive and prognostic impact, whereas KRAS mutation is of poor prognostic value. + + + + 27133754 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 10 + 52 + 0 + + + + + + + 18 + EGFR/PI3K/Akt/mTOR/IKK-beta/NF-kappaB signaling promotes head and neck cancer progression. + + + + 26895469 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 10 + 20 + 0 + + + + + + + 18 + these findings will shed light on the role and mechanism of XIST/miR-133a/EGFR in regulating pancreatic cancer cells proliferation. XIST may serve as a potential therapeutic target in pancreatic cancer in the future. + + + + 28295543 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 10 + 19 + 0 + + + + + + + 18 + GHRH stimulates a ligand-independent activation of EGFR involving at least cAMP/PKA and Src family signaling pathways + + + + 27816751 + + + + + + + + 2017 + 12 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 23 + 10 + 3 + 0 + + + + + + + 18 + The tyrosine kinase inhibitors are widely used in patients with Non-Small Cell Lung Cancer. EGFR C797S mutation is a leading mechanism of resistance to the third-generation inhibitors. The C797S mutation appears to be an ideal target for overcoming the acquired resistance. [review] + + + + 28526474 + + + + + + + + 2017 + 12 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 16 + 11 + 29 + 0 + + + + + + + 18 + Data indicate outcomes to co-occurring genetic alterations in patients with advanced-stage EGFR-mutant lung cancer. + + + + 29106415 + + + + + + + + 2017 + 12 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 16 + 11 + 13 + 0 + + + + + + + 18 + Cancerous cells resist EGFR tyrosine kinase inhibitors through various mechanisms, the most commonly reported ones are the T790M mutation and HER2 amplification. Dual EGFR/HER2 blockade outweighs selective EGFR inhibition. [review] + + + + 28754471 + + + + + + + + 2017 + 12 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 16 + 11 + 10 + 0 + + + + + + + 18 + Results might suggest that ETS exposure during childhood or at home in adult life could influence the EGFR mutations profile in lung cancer in never smokers, reducing the probability of presenting EFGR mutation. + + + + 28987389 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 13 + 37 + 0 + + + + + + + 18 + lacking of XIAP expression resulted in a remarkable suppression of EGFR expression, consequently leading to the deficiency of anchorage-independent cell growth + + + + 28057023 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 13 + 35 + 0 + + + + + + + 18 + Results indicate the detrimental role of EGFR in the pathogenesis of obesity-related nephropathy. + + + + 27014908 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 13 + 13 + 0 + + + + + + + 18 + Controlled activation of specific EGFR, HER2 and HER3 homodimers and heterodimers caused oesophageal squamous epithelial cell migration and/or invasion. + + + + 28940194 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 12 + 24 + 0 + + + + + + + 18 + Data indicate strategies to improve the effectiveness of EGFR inhibition particularly by blocking the STAT3 pathway. + + + + 26909593 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 11 + 53 + 0 + + + + + + + 18 + report finding two different dynamic types of plasma L858R mutation during EGFR-tyrosine kinase inhibitor treatment based on a prospective randomized study + + + + 27619632 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 11 + 42 + 0 + + + + + + + 18 + luciferase reporter assay revealed that miR-545 inhibited regulated EGFR expression by affecting its 3'-UTR activity. + + + + 28364379 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 11 + 27 + 0 + + + + + + + 18 + Tumor cell content was not associated with mutational rate for EGFR, BRAF and HER2 mutations. DNA quantity was not associated with mutational rate for EGFR, KRAS, BRAF and HER2 + + + + 29175303 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 11 + 14 + 0 + + + + + + + 18 + positive and bilateral HIF2-EGFR regulatory crosstalk promotes antiestrogen resistance in estrogen receptor alpha-positive breast cancer + + + + 26849233 + + + + + + + + 2017 + 12 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 9 + 10 + 53 + 0 + + + + + + + 18 + Recent preclinical models and translational efforts have provided critical insights into the molecular mechanisms of resistance to EGFR and ALK inhibitors. In this review, we present a framework for understanding resistance to targeted therapies. We also provide overviews of the molecular mechanisms of resistance and strategies to overcome resistance among EGFR-mutant and ALK-rearranged lung cancers + + + + 28561721 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 12 + 25 + 0 + + + + + + + 18 + there is expression of EGFR at the protein level in a subset of AML, which was identified to be functionally active in ~15 % of AML patients. This suggests that future studies need to be conducted with a subset of AML patients characterized by high EGFR expression. + + + + 27488458 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 11 + 39 + 0 + + + + + + + 18 + EGFR-induced DNA methylation-mediated transcriptional silencing of tumor suppressors may have therapeutic benefits for oncogenic EGFR-mediated lung cancers and glioblastomas. + + + + 27346347 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 11 + 16 + 0 + + + + + + + 18 + H19 may regulate non-small cell lung cancer (NSCLC) metastasis through modulating cellular signaling pathway proteins related to cell proliferation and cell adhesion, including MACC1, EGFR, beta-catenin and ERK1/2. + + + + 27607135 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 11 + 7 + 0 + + + + + + + 18 + In potassium-ion-containing solution, a 30-nt long sequence located at position -272 (EGFR-272) folds into 2 main G-quadruplex structures, one parallel and one hybrid, with comparable thermal stabilities and affinities for the metal ion.The folding process is driven by a hairpin in the domain corresponding to the terminal loop which is an important stabilizing element for both G-quadruplex arrangements. + + + + 28973461 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 11 + 5 + 0 + + + + + + + 18 + Findings indicate serum pulmonary surfactant protein D (SP-D, SFTPD) level as a potential marker to estimate the efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKIs). + + + + 28745320 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 10 + 59 + 0 + + + + + + + 18 + ET-1 increased NSCLC clonal growth, whereas BQ123, ZD4054, lapatinib or gefitinib inhibited proliferation. The results indicate that ET-1 may regulate NSCLC cellular proliferation in an EGFR- and HER2-dependent manner + + + + 28153500 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 10 + 57 + 0 + + + + + + + 18 + Studies suggest that the routine clinical use of fluorescence in situ hybridization (FISH) and immunocytochemistry (ICC) may be replaced by emerging next-generation sequencing and digital, color-coded barcode technologies, which have the advantage of simultaneously evaluating anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) and epidermal growth factor receptor (EGFR) alterations in a single analysis. + + + + 28743163 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 10 + 55 + 0 + + + + + + + 18 + The protein kinase activity of PI3K phosphorylates serine residue 70 on Src to enhance its activity and induce EGFR transactivation following betaAR stimulation. + + + + 27169346 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 10 + 29 + 0 + + + + + + + 18 + EGFR mutation is associated with colon and pancreatic cancer. + + + + 29153095 + + + + + + + + 2017 + 12 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 12 + 2 + 10 + 4 + 0 + + + + + + + 18 + EGFR activation increased constitutive pre-mRNA splicing in MDA-MB-468 cells + + + + 27109354 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 26 + 0 + 26 + 0 + + + + + + + 18 + EGFR Mutation Subtypes are associated with response to chemotherapy in lung cancer. + + + + 27908825 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 26 + 0 + 18 + 0 + + + + + + + 18 + through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers. + + + + 27330189 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 26 + 0 + 6 + 0 + + + + + + + 18 + The low abundance of adaptors relative to EGFR could be responsible for previous observations that only a fraction of total cell surface EGFR is capable of rapid endocytosis, high-affinity binding, and mitogenic signaling. + + + + 27405981 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 25 + 15 + 24 + 0 + + + + + + + 18 + characterized the specific interactome of the epidermal growth factor receptor (EGFR) family member ERBB2 when in the form of a homodimer or when in the form of a heterodimer with either EGFR or ERBB3. + + + + 27405979 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 25 + 15 + 24 + 0 + + + + + + + 18 + EGFR co-Mutation is associated with response to chemotherapy in lung cancer. + + + + 27639677 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 25 + 15 + 17 + 0 + + + + + + + 18 + EGFR-related signal pathways, including EGFR-PI3K-Akt and EGFR-Erk1/2 pathways, were involved in isorhapontigenin-induced cell growth inhibition and apoptosis in prostate carcinoma cells. + + + + 28422286 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 25 + 15 + 10 + 0 + + + + + + + 18 + Sequencing of childhood ependymoma samples indicate Sec61 gamma subunit protein (SEC61G)-epidermal growth factor receptor (EGFR) chimeric mRNAs in one infratentorial ependymoma , arguing that this fusion occurs in a small proportion of these tumors. + + + + 29092923 + + + + + + + + 2017 + 11 + 25 + 12 + 33 + 0 + + + + + + + + + 2017 + 11 + 25 + 12 + 38 + 0 + + + + + + + 18 + the activation of EGFR plays a critical role in the switch between cell survival and cell death induced by autophagy in hypoxia. + + + + 27166522 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 14 + 11 + 0 + + + + + + + 18 + ALK/EGFR mutational co-alterations are associated with response to chemotherapy in Non-Small Cell Lung Cancer. + + + + 28007627 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 13 + 57 + 0 + + + + + + + 18 + EGFR mutations are associated with Resistance to chemptherapy in Lung cancer. + + + + 27613527 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 13 + 42 + 0 + + + + + + + 18 + The authors have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that multimerization can be blocked by mutations in a specific region of Domain IV of the extracellular module. + + + + 27017828 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 13 + 38 + 0 + + + + + + + 18 + Here the authors show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). + + + + 28195529 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 13 + 31 + 0 + + + + + + + 18 + Overexpression of LAMC2 and knockdown of CD82 markedly promoted GC cell invasion and activated EGFR/ERK1/2-MMP7 signaling via upregulation of the expression of phosphorylated (p)-EGFR, p-ERK1/2 and MMP7. + + + + 28252644 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 11 + 29 + 0 + + + + + + + 18 + EGFR and/or HER2 transactivation is involved in cell adhesion, cell migration and VEGF secretion produced by GHRH. + + + + 28193499 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 11 + 6 + 0 + + + + + + + 18 + EGFR mutations were frequently seen in histologically low- and intermediate-grade tumors but not a prognostic factor + + + + 29065153 + + + + + + + + 2017 + 11 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 18 + 10 + 56 + 0 + + + + + + + 18 + EGFR mutation is associated with lung adenocarcinoma. + + + + 28934759 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 14 + 2 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small cell lung cancer. + + + + 26899757 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 13 + 48 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small cell lung cancer. + + + + 26917231 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 13 + 41 + 0 + + + + + + + 18 + EGFR Overexpression or EGFR Gene Amplification is associated with esophageal squamous cell carcinoma. + + + + 26980473 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 13 + 32 + 0 + + + + + + + 18 + most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR + + + + 27089454 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 13 + 6 + 0 + + + + + + + 18 + EGFR mutation is associated with age and obesity in lung adenocarcinomas. + + + + 28689332 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 11 + 43 + 0 + + + + + + + 18 + Association for the Study of Lung Cancer commissioned consensus statement, key pathologic, diagnostic, and therapeutic considerations, such as optimal choice of EGFR tyrosine kinase inhibitors and management of brain metastasis, are discussed[review] + + + + 27229180 + + + + + + + + 2017 + 11 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 11 + 10 + 37 + 0 + + + + + + + 18 + EGFR colocalization with GRB2 as assessed by PLA is not correlated with EGFR expression levels or mutation status, defining a patient group that may show EGFR pathway activation, as illustrated by its prognostic value. + + + + 27449805 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 12 + 48 + 0 + + + + + + + 18 + EGFR and RANK combinatorial in vitro analyses revealed a significant upregulation of AKT and ERK signaling after EGF stimulation in cell lines and also an increase of breast cancer cell invasiveness. + + + + 29025596 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 12 + 11 + 0 + + + + + + + 18 + High EGFR expression is associated with head and neck squamous cell carcinoma. + + + + 28823958 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 11 + 58 + 0 + + + + + + + 18 + EGFR internal tandem duplication is associated with Clear cell sarcoma of kidney. + + + + 28440018 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 11 + 55 + 0 + + + + + + + 18 + Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells + + + + 27180173 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 11 + 54 + 0 + + + + + + + 18 + Study shows how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. Results reveal how responses to different EGFR ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (RTK) signaling specificity. + + + + 28988771 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 11 + 35 + 0 + + + + + + + 18 + This review highlights two approaches our laboratory has taken to gain more detailed information about both aspects: Surface patterned ligands to examine recruitment of the signaling machinery, and mutational analysis to examine the regulatory role of EGFR's juxtamembrane segment + + + + 28024796 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 11 + 33 + 0 + + + + + + + 18 + Overexpression of REP1 in BEAS-2B cells enhanced cell growth and anchorage-independent colony formation with little increase in EGFR level and STAT3 activation. + + + + 28230863 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 10 + 49 + 0 + + + + + + + 18 + The aim of this study is to explore EGFR, hMLH-1/hMSH-2 and microsatellite instability (MSI) as potential prognostic factors of recurrence in clinical stage I testicular germ cell tumours. + + + + 28320414 + + + + + + + + 2017 + 11 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 11 + 4 + 10 + 38 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas. + + + + 28329143 + + + + + + + + 2017 + 10 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 28 + 13 + 15 + 0 + + + + + + + 18 + This study highlights a tumor suppressor role for miR-520a-3p in colorectal cancer via the regulation of EGFR expression. + + + + 28738328 + + + + + + + + 2017 + 10 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 28 + 13 + 15 + 0 + + + + + + + 18 + Studies showed that EGFR may play a significant role in prostate cancer progression especially in African American men, as EGFR is increased in these patients. [review] + + + + 27447901 + + + + + + + + 2017 + 10 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 28 + 12 + 40 + 0 + + + + + + + 18 + We show that the increased gefitinib sensitivity in cancer cells induced by DHHC20 inhibition is mediated directly through loss of palmitoylation on a previously identified cysteine residue in the C-terminal tail of EGFR. + + + + 28899783 + + + + + + + + 2017 + 10 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 28 + 12 + 17 + 0 + + + + + + + 18 + Significance of EGFR Expression in Circulating Tumor Cells + + + + 28560681 + + + + + + + + 2017 + 10 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 28 + 10 + 45 + 0 + + + + + + + 18 + Pretreatment neutrophil-to-lymphocyte ratio seems to represent a reliable, simple, and easy to reproduce laboratory tool to predict outcome and response to cancer therapies in this setting of Western Caucasian patients with EGFR-mutated on-small-cell lung cancer + + + + 28731495 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 12 + 49 + 0 + + + + + + + 18 + Serum CYFRA 21-1 level may be a predictive factor for patients with non-small cell lung cancers treated with EGFR-TKIs, regardless of EGFR mutation status. + + + + 28982900 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 12 + 34 + 0 + + + + + + + 18 + Ertredin suppressed tumor growth in an allograft transplantation mouse model injected with human EGFRvIII- or wild-type EGFR-expressing NIH3T3 (NIH3T3/EGFRvIII) cells. + + + + 27431653 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 11 + 48 + 0 + + + + + + + 18 + provides definitive evidence that sustained activation of EGFR in proximal epithelia is sufficient to cause spontaneous, progressive renal tubulointerstitial fibrosis, evident by epithelial dedifferentiation, increased myofibroblasts, immune cell infiltration, and increased matrix deposition + + + + 28626027 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 11 + 33 + 0 + + + + + + + 18 + EGFR mutation rates were higher in Primary Pulmonary Enteric Adenocarcinoma , which are cytokeratin 20- and caudal type homeobox transcription factor 2-negative (P=.041). + + + + 28953659 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 11 + 20 + 0 + + + + + + + 18 + Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme + + + + 28934307 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 11 + 15 + 0 + + + + + + + 18 + ADx-SuperARMS EGFR assay is likely to be a highly sensitive and specific method to noninvasively detect plasma EGFR mutations of patients with advanced lung adenocarcinoma + + + + 28829813 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 10 + 56 + 0 + + + + + + + 18 + These findings suggest a potential functional link in colorectal cancer between PODXL, EGFR and BRAF. + + + + 27160084 + + + + + + + + 2017 + 10 + 21 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 21 + 10 + 28 + 0 + + + + + + + 18 + Relapse-free survival (RFS) was significantly shorter in patients who were double positive for EGFR and HER2. Our results suggest that EGFR and HER2 are potential therapeutic targets and that their co-expression is a prognostic factor for cervical adenocarcinoma. + + + + 28859123 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 13 + 9 + 0 + + + + + + + 18 + The Roche cobas(R) EGFR mutation test v2, based on real time RT-PCR, is a reliable option for testing EGFR mutations in clinical practice, either using tissue-derived DNA or plasma-derived cfDNA. + + + + 28129709 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 13 + 5 + 0 + + + + + + + 18 + Results have shown crosstalk among the EGFR cascade and Sp1 and DPD expressions in EGFR mutant non-small-cell lung cancer cell lines. EGF-induced Sp1 up-regulation resulted in both DPYD mRNA and DPD protein expressions. + + + + 27268079 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 12 + 52 + 0 + + + + + + + 18 + TAZ was positively correlated with EGFR signaling, and coexpression of TAZ/EGFR conferred a poorer prognosis in lung cancer patients. Our findings identify that targeting TAZ-mediated compensatory mechanism is a novel therapeutic approach to overcome gefitinib resistance in KRAS-mutant/EGFR-wild-type non-small-cell lung cancer . + + + + 28710768 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 12 + 51 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in non-small-cell lung cancer. + + + + 28777825 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 12 + 9 + 0 + + + + + + + 18 + The role of the EGFR and Met interaction in glioblastoma.The role of EGFR in the glioblastoma resistance to treatment. [review] + + + + 28004613 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 11 + 7 + 0 + + + + + + + 18 + Apatinib reversed the drug resistance to EGFR inhibitor gefitinib, both in nude mice xenograft with T790M-related acquired resistance and in advanced non-small cell lung carcinoma patients. + + + + 28822888 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 10 + 59 + 0 + + + + + + + 18 + Differences between KRAS and EGFR alterations were not significant. The great majority of the analyzed tumor sections (16/19) exhibited two or more morphological growth patterns. Mutant allele frequencies were significantly higher in segments with a predominant solid pattern compared to all other histologies (p < 0.01). + + + + 28699162 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 10 + 43 + 0 + + + + + + + 18 + In mice, both EGFR and phosphorylated EGFR decreased with increasing percent body fat. Hydrodynamic transfection of EGFR plasmids in mice corrected fatty liver regeneration, reducing liver injury, increasing proliferation, and improving survival after 80% resection. Loss of EGFR expression is rate limiting for liver regeneration in obesity. + + + + 28655714 + + + + + + + + 2017 + 10 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 14 + 10 + 11 + 0 + + + + + + + 18 + DNA copy number variation in EGFR gene is associated with glioblastoma. + + + + 27502248 + + + + + + + + 2017 + 10 + 7 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 7 + 12 + 3 + 0 + + + + + + + 18 + High EGFR expression is associated with resistance to sorafeinib in liver cancer. + + + + 28423613 + + + + + + + + 2017 + 10 + 7 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 7 + 11 + 56 + 0 + + + + + + + 18 + This study explores the prognostic effect of MET, MET gene copy number, polysomy of chromosome 7, IGF1R gene copy number and IGF-1 expression in tumor epithelial cells of primary non-small-cell lung cancer in 326 patients. + + + + 28742836 + + + + + + + + 2017 + 10 + 7 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 7 + 10 + 41 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small cell lung cancer. + + + + 28107191 + + + + + + + + 2017 + 10 + 7 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 7 + 10 + 40 + 0 + + + + + + + 18 + Study have shown that EGFR gene amplification is relatively common in intestinal adenocarcinomas of the stomach, gastro-oesophageal junction and distal oesophagus. + + + + 27387915 + + + + + + + + 2017 + 10 + 7 + 10 + 2 + 0 + + + + + + + + + 2017 + 10 + 7 + 10 + 21 + 0 + + + + + + + 18 + EGFR signaling is central to macrophage function in response to enteric bacterial pathogen + + + + 27482886 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 14 + 16 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in Non-Small-Cell Lung Cancer. + + + + 27686971 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 13 + 58 + 0 + + + + + + + 18 + NCTD suppressed not only the expression of the total EGFR and the phosphorylated EGFR but also the expression of the total c-Met. + + + + 28086832 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 12 + 14 + 0 + + + + + + + 18 + The frequency of T790M mutation in this study was lower than that in previous reports examining western patients. These results suggest that continuous treatment with EGFR-TKI after disease progression may enhance the frequency of EGFR T790M mutation in rebiopsy samples. + + + + 27821131 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 12 + 14 + 0 + + + + + + + 18 + Study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. + + + + 28700691 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 12 + 4 + 0 + + + + + + + 18 + EGFR/EGFRvIII remodels the cytoskeleton via epigenetic silencing of AJAP1 in glioma cells. + + + + 28634045 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 11 + 39 + 0 + + + + + + + 18 + Bile duct adenocarcinoma cells overexpress claudin-18 via the EGFR/RAS/ERK pathway, contributing to cell proliferation and invasion. + + + + 28624624 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 11 + 19 + 0 + + + + + + + 18 + Dual MET and SMO Inhibitors are potent antiproliferative agents in EGFR-Tyrosine kinase inhibitors resistant human non small cell lung cancer. + + + + 28787156 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 10 + 43 + 0 + + + + + + + 18 + Results indicate that epidermal growth factor receptor(EGFR)/programmed cell death 1 ligand 1 (PD-L1) pairs could separate the survival between EGFR low/PD-L1 positive and EGFR high/PD-L1 negative groups. + + + + 28192623 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 10 + 42 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in Non-Small-Cell Lung Cancer. + + + + 27894601 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 10 + 16 + 0 + + + + + + + 18 + EGFR mutation is associated with Lung Cancer. + + + + 27256487 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 10 + 6 + 0 + + + + + + + 18 + High EGFR expression is associated with pancreatic cancer. + + + + 27617577 + + + + + + + + 2017 + 9 + 30 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 30 + 10 + 4 + 0 + + + + + + + 18 + EGFR and C/EBP-beta oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta isoform + + + + 27572958 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 13 + 53 + 0 + + + + + + + 18 + Studies indicate that positive PD-L1 expression was significantly correlated with KRAS mutation and EGFR mutation. + + + + 28423587 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 13 + 42 + 0 + + + + + + + 18 + Piccolo contributes to tumor aggressiveness in esophageal squamous cell carcinoma, likely by stabilizing EGFR and promoting EGFR-dependent signaling. + + + + 28263981 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 13 + 38 + 0 + + + + + + + 18 + Finally, the authors show that EGFR-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation. + + + + 28180113 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 12 + 54 + 0 + + + + + + + 18 + Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases + + + + 28025329 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 12 + 45 + 0 + + + + + + + 18 + Study shows that EGFR negatively regulates POPDC1 expression in breast cancer cell lines and that overexpression of POPDC1 can reduce EGFR-mediated cell migration and proliferation in breast cancer cells. + + + + 28807821 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 12 + 30 + 0 + + + + + + + 18 + The present findings indicate that genetic variation in EGFR may contribute to the attainment of extreme old age in Japanese. + + + + 27365368 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 11 + 33 + 0 + + + + + + + 18 + developed a simulator to accurately calculate the dynamic sensitivity of extracellular-signal-regulated kinase (ERK) activity (ERK*) and Akt activity (Akt*), downstream of the ErbB receptors stimulated with epidermal growth factor (EGF) and heregulin (HRG) + + + + 28542548 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 11 + 19 + 0 + + + + + + + 18 + EGFR amplification/EGFRvIII mutation can repress the expression of Pri-miR-524 by histone modification. MiR-524-3p and miR-524-5p inhibited TGF/beta, Notch and the Hippo pathway by targeting Smad2, Hes1 and Tead1, respectively; these pathways repressed their common downstream transcription factor, C-myc. + + + + 28778566 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 10 + 51 + 0 + + + + + + + 18 + The searched for functional interactions between EGFR and D2-like receptors, focusing on the molecular mechanisms involved in the EGFR-mediated regulation of dopamine receptor signaling. + + + + 28579429 + + + + + + + + 2017 + 9 + 23 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 23 + 10 + 18 + 0 + + + + + + + 18 + Data show that pyruvate kinase M2 (PKM2) directly interacted with mutant growth factor receptor (EGFR) and heat-shock protein 90 (HSP90), and thus stabilized EGFR by maintaining its binding with HSP90 and co-chaperones. + + + + 26500058 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 12 + 43 + 0 + + + + + + + 18 + EGF induces hair follicle-derived mesenchymal stem cell proliferation through the EGFR/ERK and AKT pathways, but not through STAT-3. The G1/S transition was stimulated by upregulation of cyclinD1 and inhibition of p16 expression. + + + + 27702388 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 12 + 33 + 0 + + + + + + + 18 + High EGFR expression is associated with metastasis of glioblastoma. + + + + 27546621 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 12 + 20 + 0 + + + + + + + 18 + We anticipate rapid adoption of EGFR-nanolipoprotein particles for structural studies of full-length receptors and drug screening, as well as for the in vitro characterization of ErbB heterodimers and disease-relevant mutants. + + + + 28586369 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 11 + 46 + 0 + + + + + + + 18 + our data suggest that dormant cancer cells with a high MIG6 expression level might be one of the causes of EGFR-TKI resistance in EGFR mutant lung cancer cells. + + + + 27893711 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 11 + 21 + 0 + + + + + + + 18 + The MET mutation is involved in the pathogenesis of EGFR-mutant lung cancer. + + + + 28294470 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 11 + 3 + 0 + + + + + + + 18 + Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor + + + + 28166195 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 10 + 16 + 0 + + + + + + + 18 + results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFalpha-TGFalpha-EGFR. + + + + 28166193 + + + + + + + + 2017 + 9 + 16 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 16 + 10 + 16 + 0 + + + + + + + 18 + our findings identified a subset of EGFR and HER2 exon 20 insertion mutations that are sensitive to existing covalent quinazoline-based EGFR/HER2 inhibitors, with implications for current clinical treatment and next-generation small-molecule inhibitors. + + + + 28363995 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 14 + 43 + 0 + + + + + + + 18 + Our findings identify aberrant active integrin b1-driven Src-Akt hyperactivation as a primary resistance mechanism to cetuximab in PDAC cells and offer an effective therapeutic strategy to overcome this resistance using an EGFR and NRP1 dual targeting antibody + + + + 27797376 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 11 + 43 + 0 + + + + + + + 18 + miR-223 downregulated the local expression of epidermal growth factor (EGF), leading to decreased activation of EGF receptor (EGFR) on target cells and, eventually, dampening a positive EGF-EGFR autocrine/paracrine stimulation loop induced by the post-surgical wound-healing response. + + + + 26876200 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 11 + 35 + 0 + + + + + + + 18 + our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore. + + + + 27449755 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 11 + 6 + 0 + + + + + + + 18 + In FGF9-overexpressing colorectal cancer cell lines, FGF9 overexpression induced strong resistance to anti-EGFR therapies via the enforced FGFR signal, and this resistance was cancelled by the application of an FGFR inhibitor. + + + + 26916220 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 10 + 47 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in neoplasms. + + + + 27294619 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 10 + 44 + 0 + + + + + + + 18 + The percentage of EGFR-mutated lung adenocarcinoma cells in the tumor is associated with response to tyrosine kinase inhibitors. + + + + 28520821 + + + + + + + + 2017 + 9 + 9 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 9 + 10 + 38 + 0 + + + + + + + 18 + we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. + + + + 26876213 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 13 + 35 + 0 + + + + + + + 18 + EGFR mutations were observed in 103 patients (12%) and were correlated with positivie prognostic factors in resected non-small-cell lung cancer. + + + + 27530493 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 13 + 28 + 0 + + + + + + + 18 + upregulation of EREG expression through promoter demethylation might be an important means of activating the EGFR pathway during the genesis of colorectal adenocarcinoma (CRC) and potentially other cancers. + + + + 27270421 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 13 + 13 + 0 + + + + + + + 18 + we identified that BPA was able to attenuate the inhibitory effect of an EGFR targeted drug in a longer-term anchorage-independent growth assay. These findings provide a potential mechanistic basis for environmental chemicals such as BPA in potentiating a hyperproliferative and death-resistant phenotype in cancer cells by activating mitogenic pathways to which the tumor cells are addicted for survival. + + + + 28426875 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 13 + 1 + 0 + + + + + + + 18 + the Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway. + + + + 26686095 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 12 + 53 + 0 + + + + + + + 18 + EGFR CNG assessed by FISH appears to identify a subgroup of patients with esophageal cancer who may benefit from gefitinib as a second-line treatment. Results of this study suggest that anti-EGFR therapies should be investigated in prospective clinical trials in different settings in EGFR FISH-positive and, in particular, EGFR-amplified esophageal cancer. + + + + 28537764 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 12 + 37 + 0 + + + + + + + 18 + Binding of FM807 to the N-terminus of Hsp90 disrupted Hsp90/client complexes, resulting in degradation of the Hsp90 client protein EGFR and inhibition of the downstream pathway. + + + + 28157708 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 12 + 35 + 0 + + + + + + + 18 + EGFR transactivation resulted in the activation of ERK1/2 by a mechanism that is dependent on Gi/o protein and that requires matrix metalloproteinase-mediated proligand shedding + + + + 28424220 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 12 + 21 + 0 + + + + + + + 18 + Especially the association to eGFR highlights the importance for future studies to address renal function as possible influence on betatrophin regulation and consider eGFR as potential confounder when analyzing the role of betatrophin in humans + + + + 28257453 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 12 + 9 + 0 + + + + + + + 18 + EGFR and EGF expression showed no significant difference between placentas from normal pregnancies and those complicated with preeclampsia. + + + + 27657362 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 11 + 48 + 0 + + + + + + + 18 + Treatment with cucurbitacin B to sestrin-3 siRNA treated EGFR-mutant cells further amplified the decrease in cell-viability and caused more sustained G2-phase cell cycle arrest, suggesting that these effects are mediated partly through sestrin-3. + + + + 27881463 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 11 + 39 + 0 + + + + + + + 18 + We could identify no prognostic effect of the KRAS or EGFR driver and TP53 tumor suppressor comutation. + + + + 28453411 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 11 + 21 + 0 + + + + + + + 18 + EGFR upregulation was detected in the group of thyroid cancer patients with malignant diagnosis, no caveolin-1 expression, and wild-type BRAF. + + + + 27818286 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 11 + 1 + 0 + + + + + + + 18 + High risk HPV E6 down-regulates expression of miR-146a miR-146a inhibits EGFR expression and proliferation of human foreskin fibroblasts and cervical carcinoma cell lines in vitro. + + + + 27818285 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 11 + 1 + 0 + + + + + + + 18 + The Hippo effector YAP plays a crucial role in linking the PD-L1 and EGFR-TKI resistance by directly regulating the expression of PD-L1 in lung cancer cells. + + + + 28684311 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 10 + 44 + 0 + + + + + + + 18 + The interaction between CSR1 and SF3A3 led to migration of SF3A3 from nucleus to cytoplasm. The cytoplasmic redistribution of SF3A3 significantly reduced the splicing efficiency of epidermal growth factor receptor and platelet-derived growth factor receptor. + + + + 27148859 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 10 + 20 + 0 + + + + + + + 18 + EGFR/chromosome 7 gains distinguish a group of patients with prostate cancer with a higher risk of death from cancer. + + + + 27864120 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 10 + 18 + 0 + + + + + + + 18 + silencing HDAC7 can reset the tumor suppressor activity of STAT3, independently of the EGFR/PTEN/TP53 background of the glioblastoma. + + + + 26853466 + + + + + + + + 2017 + 9 + 2 + 10 + 2 + 0 + + + + + + + + + 2017 + 9 + 2 + 10 + 9 + 0 + + + + + + + 18 + Data suggest that NDRG1 attenuates oncogenic signaling by inhibiting formation of EGFR/HER2 and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degradation. (NDRG1 = N-myc downstream regulated gene 1 protein; EGFR = epidermal growth factor receptor; HER = human epidermal growth factor receptor) [REVIEW] + + + + 28615452 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 13 + 11 + 0 + + + + + + + 18 + EGFR positivity was independently associated with a worse outcome in adenocarcinoma of the esophagogastric junction. + + + + 28551654 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 12 + 46 + 0 + + + + + + + 18 + Atomistic molecular dynamics simulations show that N-glycosylation of the EGFR extracellular domain plays critical roles in the binding of growth factors, monoclonal antibodies, and the dimeric partners to the monomeric EGFR extracellular domain. + + + + 28486782 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 12 + 36 + 0 + + + + + + + 18 + This analysis is the first to reveal the relationship between EGFR mutation status and the spatial distribution of brain metastases of lung cancer. + + + + 26519739 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 12 + 27 + 0 + + + + + + + 18 + GOLM1 selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. + + + + 27569582 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 11 + 36 + 0 + + + + + + + 18 + EGFR mutation turned out to have no change after EGFR-TKI therapy. + + + + 28333951 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 11 + 32 + 0 + + + + + + + 18 + Simultaneous suppression of ErbB kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression. + + + + 28450158 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 10 + 58 + 0 + + + + + + + 18 + Study shows that sequential epidermal growth factor receptor (EGFR) amplification and EGFRvIII mutations might represent concerted evolutionary events that drive the aggressive nature of glioblastoma by promoting invasion and angiogenesis via distinct signaling pathways. + + + + 27286795 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 10 + 52 + 0 + + + + + + + 18 + The occurrence of EGFR mutations in lung adenocarcinomas gradually increases with age, being attributed mainly to the increment of the L858R frequency in non-smokers. + + + + 27259329 + + + + + + + + 2017 + 8 + 26 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 26 + 10 + 41 + 0 + + + + + + + 18 + in HER2-overexpressing D492 cells, EGFR can behave as a tumor suppressor, by pushing the cells towards epithelial differentiation + + + + 26686087 + + + + + + + + 2017 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 19 + 12 + 21 + 0 + + + + + + + 18 + High baseline plasma epidermal growth factor receptor (EGFR) mutation (pEGFRmut) concentrations were associated with shorter progression-free survival (8.43 months) than low baseline pEGFRmut (16.23 months). + + + + 28061461 + + + + + + + + 2017 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 19 + 11 + 55 + 0 + + + + + + + 18 + Afatinib was effective against leptomeningeal carcinomatosis particularly in patients with non-small cell lung cancer (NSCLC) harboring uncommon EGFR mutations. The criteria for selecting a specific EGFR tyrosine kinase inhibitor for therapy of NSCLC should include its ability to penetrate CSF and its efficacy against specific mutation types. + + + + 28739703 + + + + + + + + 2017 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 19 + 11 + 36 + 0 + + + + + + + 18 + The aim of this review is to report recent advances and future perspectives in the treatment of EGFR-mutated non-small cell lung cancer (NSCLC), highlighting the resistance mechanisms that underlie disease progression. + + + + 28708233 + + + + + + + + 2017 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 19 + 11 + 1 + 0 + + + + + + + 18 + Pretreatment nutritional status is a prognostic marker in EGFR mutated non-small cell lung carcinoma patients treated with protein kinase inhibitors. + + + + 27017943 + + + + + + + + 2017 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 19 + 10 + 26 + 0 + + + + + + + 18 + CD133 facilitates cancer stem cell-like properties by stabilizing EGFR-AKT signaling in HCC. + + + + 28034805 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 12 + 35 + 0 + + + + + + + 18 + CMTM3 decreases EGFR expression, facilitates EGFR degradation, and inhibits the EGF-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity. + + + + 27867015 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 12 + 33 + 0 + + + + + + + 18 + MET inhibition by SGX523 and EGFR-MET heterodimerisation are determined by EGFR genotype. + + + + 28141869 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 12 + 21 + 0 + + + + + + + 18 + Results report that EGFR expression is significantly increased in tumors of lung adenocarcinoma patients and is negatively correlated with the expression of DEPTOR. The study also study uncovers the important inhibitory role of DEPTOR in lung adenocarcinoma progression and reveals a novel mechanism that EGFR downregulates DEPTOR expression to facilitate tumor growth. + + + + 26896556 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 12 + 20 + 0 + + + + + + + 18 + YAP function is required for NF2-null Schwann cell survival, proliferation, and tumor growth in vivo Moreover, YAP promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG, which codes for the EGFR ligand, amphiregulin. + + + + 27216189 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 11 + 52 + 0 + + + + + + + 18 + Studies indicate that drugs targeting erb-b2 receptor tyrosine kinase 2 (c-erb B2/neu), vascular endothelial growth factor (VEGF) and EGF receptor (EGFR) under development for Inflammatory breast cancer (IBC). + + + + 27926493 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 11 + 1 + 0 + + + + + + + 18 + Studies indicate that circulating free tumor-derived DNA (ctDNA) in blood has been proposed as an alternative source of tumor DNA for the detection of epidermal growth factor receptor (EGFR) mutations harbored in non-small-cell lung cancer (NSCLC). + + + + 27980215 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 10 + 55 + 0 + + + + + + + 18 + NECAP2 does not regulate the clathrin-mediated endocytosis of these cargos, the degradation of EGFR or the recycling of transferrin along the slow, Rab11-dependent recycling pathway. We show that protein knockdown of NECAP2 leads to enlarged early endosomes and causes the loss of the clathrin adapter AP-1 from the organelle. + + + + 27206861 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 10 + 34 + 0 + + + + + + + 18 + SLC9A9 has an oncogenic function by being related to EGFR signaling, suggesting SLC9A9 may be a novel prognostic indicator and a therapeutic target in colorectal cancer + + + + 28476790 + + + + + + + + 2017 + 8 + 12 + 10 + 3 + 0 + + + + + + + + + 2017 + 8 + 12 + 10 + 7 + 0 + + + + + + + 18 + Studies indicate that high epidermal growth factor receptor(EGFR) expression significantly predicts poor prognosis, suggesting that high EGFR expression may serve as a predictive biomarker for poor prognosis in patients with gastric cancer. + + + + 28199988 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 12 + 42 + 0 + + + + + + + 18 + Data suggest ATM and E-cadherin expression as potential supportive predictive markers for EGFR-targeted therapy. + + + + 28199979 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 12 + 42 + 0 + + + + + + + 18 + hypoxic activation of EGFR results in phosphorylation of ERK. + + + + 28188223 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 53 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small cell lung carcinoma. + + + + 27923629 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 51 + 0 + + + + + + + 18 + The trial was stopped prematurely at 63% of originally planned sample size due to accumulating evidence that epidermal growth factor receptor (EGFR) gene copy number should not be used to select NSCLC patients to first-line therapy with EGFR tyrosine kinase inhibitors (TKIs). + + + + 27924059 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 51 + 0 + + + + + + + 18 + These results were consistent with the data of the clinical specimens. miR-122a could be a positive factor of zonulin by targeting EGFR, which increased the intestinal epithelial permeability in vivo and in vitro. + + + + 28641303 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 47 + 0 + + + + + + + 18 + EGFR overexpression was reported in the majority of patients with Esophageal squamous cell carcinoma (ESCC) in northeastern Iran. Moreover, EGFR overexpression was significantly associated with complete pathologic response. + + + + 28412829 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 22 + 0 + + + + + + + 18 + This study identified a novel role of neuregulin-1 (NRG-1)/ERBB signaling in the control of proinflammatory activation of monocytes + + + + 28235789 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 15 + 0 + + + + + + + 18 + EGFR activation leads to the induction of miR-96 expression and suppression of ETV6, which contributes to prostate cancer progression. + + + + 27746161 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 3 + 0 + + + + + + + 18 + Targeting of a peripheral modulator of EGFR signaling, DHHC20, causes a loss of signal regulation and susceptibility to EGFR inhibitor-induced cell death. + + + + 27153536 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 11 + 2 + 0 + + + + + + + 18 + Mutation in EGFR gene is associated with Advanced Lung Adenocarcinoma. + + + + 27518729 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 10 + 20 + 0 + + + + + + + 18 + Oncogenic activation of EGFRwt in GBM is likely maintained by a continuous EGFL7 autocrine flow line. + + + + 27725228 + + + + + + + + 2017 + 8 + 5 + 10 + 2 + 0 + + + + + + + + + 2017 + 8 + 5 + 10 + 7 + 0 + + + + + + + 18 + High expression of SLC34A2 was identified in about 2/3 patients and correlated with significantly better patient's overall survival. Epidermal growth factor receptor mutations were detected in about 53% of patients with no statistically significant difference to patient's overall survival. Anaplastic lymphoma kinase rearrangement was found in 8 out of 175 patients, harboring this abnormality leads to shorter overall survi + + + + 28720066 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 13 + 8 + 0 + + + + + + + 18 + our results indicate that EGFR promotes survival of prostate tumor-initiating cells and circulating tumor cells that metastasize to bone, whereas HER2 supports the growth of prostate cancer cells once they are established at metastatic sites + + + + 27793843 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 12 + 57 + 0 + + + + + + + 18 + The conjugation of benzylguanine-modified auristatin F to EGFR-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations. + + + + 27502168 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 12 + 56 + 0 + + + + + + + 18 + High EGFR expression is associated with glioma. + + + + 26980765 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 12 + 56 + 0 + + + + + + + 18 + F25P preproinsulin effectively reduced the concentrations of EGF, VEGF, and MMP-9 in the blood of tumor-bearing mice with EGFR-mutant glioblastoma. + + + + 27317648 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 12 + 41 + 0 + + + + + + + 18 + The study found different epidermal growth factor receptor mutation status between different lesions in lung adenocarcinoma presenting as multiple ground-glass opacity lesions. + + + + 27032467 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 11 + 52 + 0 + + + + + + + 18 + EGFR regulates iron homeostasis to promote non-small cell lung cancer growth through redistribution of transferrin receptor 1. + + + + 27523281 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 11 + 19 + 0 + + + + + + + 18 + Conformational stability of the EGFR as influenced by glycosylation, dimerization and EGF hormone binding has been described. + + + + 28019699 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 11 + 0 + 0 + + + + + + + 18 + ASCT2 is an EGFR-associated protein that can be co-targeted by cetuximab, leading to sensitization of cetuximab-treated cells to ROS-induced apoptosis. + + + + 27450723 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 10 + 39 + 0 + + + + + + + 18 + Met inhibition is an effective strategy to overcome resistance of certain EGFR-mutated non-small cell lung carcinomas with Met amplification to protein kinase inhibitors. + + + + 27450722 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 10 + 39 + 0 + + + + + + + 18 + our results identified a novel EGFR-activating mechanism in which SPINK6 has a critical role in promoting nasopharyngeal carcinoma metastasis + + + + 27671677 + + + + + + + + 2017 + 7 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 29 + 10 + 7 + 0 + + + + + + + 18 + EGFR p.T790M mutation is associated with lung adenocarcinoma. + + + + 27750395 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 13 + 36 + 0 + + + + + + + 18 + signaling is critical for progression of Staphylococcus aureus toxic shock syndrome + + + + 27414801 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 13 + 13 + 0 + + + + + + + 18 + This meta-analysis demonstrates that EGFR overexpression is closely associated with reduced survival in patients with cervical cancer. These results may facilitate the individualized management of clinical decisions for anti-EGFR therapies in cervical cancer patients + + + + 27438047 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 12 + 47 + 0 + + + + + + + 18 + Presence of exosomal EGFR in PCa patient exosomes may present a novel approach for measuring of the disease state + + + + 27152724 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 12 + 35 + 0 + + + + + + + 18 + EGFR genes are associated with overexpression of CDH5 through increased phosphorylation of EGFR and downstream Akt pathways. + + + + 27362942 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 12 + 26 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in lung adenocarcinoma. + + + + 28063177 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 12 + 16 + 0 + + + + + + + 18 + Studies indicate that golgi membrane protein 1 (GOLM1) may promote HCC by regulation of epidermal growth factor receptor (EGFR) recycling, and suggest that therapeutic targeting of GOLM1 may be a potential strategy for combating hepatocellular carcinoma (HCC) metastasis. + + + + 27858335 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 11 + 38 + 0 + + + + + + + 18 + The consistent occurrence of EGFR exon 20 insertion/duplication mutations in 100% of cases of fibrous hamartoma of infancy (FHI) studied suggests that they must play a principal role in the pathogenesis of FHI, likely by conferring a potential for growth and local infiltration. + + + + 27631514 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 11 + 14 + 0 + + + + + + + 18 + Differential expression patterns of EGF, EGFR, and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium. + + + + 27285994 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 10 + 41 + 0 + + + + + + + 18 + Among patients with EGFR-mutated lung adenocarcinoma (ADC), some treated with a first-line TKI exhibited a shorter progression free survival compared with the median survival reported for those treated with first-line standard chemotherapy. + + + + 27669169 + + + + + + + + 2017 + 7 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 22 + 10 + 25 + 0 + + + + + + + 18 + CDCP1 may facilitate loss of adhesion by promoting activation of EGFR and Src at sites of cell-cell and cell-substratum contact. + + + + 27495374 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 11 + 50 + 0 + + + + + + + 18 + Studies indicate that epidermal growth factor receptor (EGFR) plays a major role for prognosis of patients after radiotherapy. + + + + 27318683 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 11 + 26 + 0 + + + + + + + 18 + Studies indicate the interaction of radiation with anti-EGFR (epidermal growth factor receptor) therapies in cancer. + + + + 27318681 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 11 + 26 + 0 + + + + + + + 18 + Treatment for patients who progress on their initial EGFR inhibitor should be tailored to identified resistance mechanisms and sites of progression. Emerging reports about resistance to third-generation EGFR inhibitors will lay the groundwork for overcoming the next generation of resistance, and further research is needed to develop more effective therapies + + + + 27196961 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 11 + 22 + 0 + + + + + + + 18 + LAMA84 and CML patients' exosomes contain amphiregulin (AREG), thus activating epidermal growth factor receptor (EGFR) signalling in stromal cells. + + + + 27196940 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 11 + 22 + 0 + + + + + + + 18 + miR-134 inhibits non-small cell lung cancer growth by targeting the EGFR. + + + + 27241841 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 10 + 38 + 0 + + + + + + + 18 + Mutation in patients with EGFR is a strong factor with which to predict outcomes in patients who received receptor tyrosine kinase inhibitors and approximately 70%-80% of patients with EGFR-mutant lung cancer initially respond to EGFR TKI therapy. + + + + 26937803 + + + + + + + + 2017 + 7 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 15 + 10 + 18 + 0 + + + + + + + 18 + mutation of PBRM1, a subunit of the SWI/SNF complex, attenuates the effects of EGFR inhibition in part by sustaining AKT signaling + + + + 28167502 + + + + + + + + 2017 + 7 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 8 + 13 + 14 + 0 + + + + + + + 18 + RET plays a role in mediating the phosphorylation of EGFR in head and neck squamous cell carcinoma. RET inhibition not only decreases tumor growth but also enhances the efficacy of EGFR inhibition with erlotinib treatment. + + + + 27090738 + + + + + + + + 2017 + 7 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 8 + 12 + 47 + 0 + + + + + + + 18 + primary aromatase inhibitor treatment modulates expression of HER-family members as well as EGFR1 and NRG1 in HER-2/neu non-amplified breast cancers in vivo + + + + 27343990 + + + + + + + + 2017 + 7 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 8 + 11 + 49 + 0 + + + + + + + 18 + Data suggest that phyto-antioxidant EGCG (epigallocatechin gallate) alters the topology of EGFR transmembrane domain in lipid bilayer and activates EGFR in the absence of EGF (epidermal growth factor), but inhibits EGF-induced EGFR activation. + + + + 28487468 + + + + + + + + 2017 + 7 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 8 + 10 + 8 + 0 + + + + + + + 18 + Data show that anti-EGFR antibody Sym004 was more sensitive significantly to cell lines with epidermal growth factor receptor (EGFR) gene amplification than those without amplification. + + + + 28038457 + + + + + + + + 2017 + 7 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 8 + 10 + 7 + 0 + + + + + + + 18 + The mutation rate of 21 exon in the lepidic was higher than that in the acinar and papillary but the mutation rate of 19 exon in the papillary was higher than that in the lepidic. + + + + 28641695 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 12 + 30 + 0 + + + + + + + 18 + EGFR TKI-sensitive mutations commonly occur in female, non-smoking and adenocarcinoma patients. The p-stage, TNM-T stage, TNM-N stage, EGFR and TTF-1 protein expression levels have close relationships with EGFR mutation status. + + + + 27992557 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 12 + 19 + 0 + + + + + + + 18 + EGFR expression was observed in 58% and c-KIT expression was seen in 30% of the cases [triple negative breast cancer] + + + + 27504546 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 11 + 35 + 0 + + + + + + + 18 + tumors from stage IV NSCLC patients harbor characteristic gene alterations, of which EGFR L858R in particular appears to be a poor prognostic factor for overall survival. + + + + 27221040 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 10 + 36 + 0 + + + + + + + 18 + L792F and C797S in addition to T790M can develop after the acquisition of resistance to afatinib. L792F and C797S should be tested in patients, particularly those whose tumors harbor moderately sensitive original mutations and those who require reductions of the afatinib dose. Patients with T790M tumors can be treated with osimertinib. + + + + 27913578 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 10 + 28 + 0 + + + + + + + 18 + The presence of EGFR mutations is significantly associated with early stage disease at initial diagnosis in lung adenocarcinomas after adjusting for age, sex, smoking status, and screening. This finding implies that EGFR mutations may play a role as a positive prognostic marker. + + + + 27861565 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 10 + 12 + 0 + + + + + + + 18 + EGFR-mutated LADC may develop through a distinct carcinogenetic pathway, in which the mPAP element may play an important role in promoting progression. + + + + 27861549 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 10 + 12 + 0 + + + + + + + 18 + Aberrant expressionof Rb is frequently occurred in lung adenocarcinoma patients with EGFR mutations. + + + + 28532538 + + + + + + + + 2017 + 7 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 7 + 1 + 10 + 8 + 0 + + + + + + + 18 + EGFR, MEK1, MEK2 and ERK1/2 co-localize on endosomes.Role of chromatin-bound EGFR in RNA polymerase 2 transcription + + + + 27587583 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 13 + 0 + 0 + + + + + + + 18 + Report EGFR inhibitory activity of quinazolines/indoles for the treatment of ovarian cancer. + + + + 28039712 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 40 + 0 + + + + + + + 18 + C terminus of Hsc70-interacting protein (CHIP) selectively interacted with epidermal growth factor receptor (EGFR) mutants and simultaneously induced their ubiquitination and proteasomal degradation. + + + + 27475501 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 27 + 0 + + + + + + + 18 + CLCb/Dyn1-dependent adaptive clathrin-mediated endocytosis selectively altered EGF receptor trafficking. + + + + 28171750 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 23 + 0 + + + + + + + 18 + CC2D1A and CC2D1B regulate degradation and signaling of EGFR. + + + + 27769858 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 21 + 0 + + + + + + + 18 + The present data indicate that HCRP1 inhibits breast cancer metastasis through downregulating EGFR phosphorylation. + + + + 27311861 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 21 + 0 + + + + + + + 18 + low gefitinib plasma concentrations in patients with exon 21 EGFR point mutations may be associated with shorter progression-free survival in non-small cell lung cancer patients + + + + 28391354 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 12 + 19 + 0 + + + + + + + 18 + our study demonstrates that COMPOUND7809 may be a promising epidermal growth factor receptor inhibitor for human lung cancer therapy. + + + + 28443496 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 11 + 39 + 0 + + + + + + + 18 + Studies indicate potential mechanisms of resistance to anti-EGFR therapies act through acquired mutations of KRAS and the EGFR ectodomain. + + + + 28368335 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 11 + 14 + 0 + + + + + + + 18 + The antioxidant N-acetylcysteine (NAC) blocked the AF-induced increase of reactive oxygen species (ROS) production, the reduction of total EGFR, and the phosphorylation of multiple nodes in EGFR/MAPK signaling pathway. P38MAPK inhibitor SB203580, but not inhibitors of EGFR (erlotinib), ERK (FR180204) and JNK (SP600125), suppressed AF-induced phosphorylation of EGFR/p38MAPK/MAPKAPK2/Hsp27 + + + + 27846303 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 58 + 0 + + + + + + + 18 + Both qualitative and quantitative analysis disclosed potential associations between computed tomography features and quantitative texture analysis parameters, EGFR mutations and prognosis + + + + 28258739 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 55 + 0 + + + + + + + 18 + EGFR gene mutation is associated with metastasis in lung cancer. + + + + 28253871 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 55 + 0 + + + + + + + 18 + In 102 patients with KRAS exon 2 wild type metastatic colorectal cancer, increased EGFR gene copy number predicted a better response and prolonged progression-free survival in anti-EGFR-treated RAS/BRAF/PIK3CA wild-type patients. Tumours with EGFR copy number below 4.0 appear to be refractory to anti-EGFR treatment. + + + + 27879995 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 31 + 0 + + + + + + + 18 + This study demonstrated that EGFR mutations are significant predictors for advanced NSCLC patients with MPE receiving second-line EGFR-TKIs treatment. + + + + 28618947 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 14 + 0 + + + + + + + 18 + This article reviews the factors associated with clinical efficacy of first-generation epidermal growth factor receptor tyrosine kinase inhibitors, such as gefitinib and erlotinib, and analyzes their potential implications with respect to clinical application. + + + + 28468578 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 12 + 0 + + + + + + + 18 + Treatment-naive patients with stage IIIB or IV NSCLC and a common EGFR mutation (exon 19 deletion or Leu858Arg) were randomly assigned (1:1) to receive afatinib (40 mg per day) or gefitinib (250 mg per day) until disease progression + + + + 27083334 + + + + + + + + 2017 + 6 + 24 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 24 + 10 + 10 + 0 + + + + + + + 18 + we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma. + + + + 28513300 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 55 + 0 + + + + + + + 18 + This article reviews aberrations in epidermal growth factor receptor, MET, and ERBB2, their therapeutic implications, and future directions in targeting these pathways. + + + + 28501091 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 55 + 0 + + + + + + + 18 + his study demonstrates arctigenin could induce cellular senescence in gallbladder cancer through the modulation of epidermal growth factor receptor pathway. These data identify epidermal growth factor receptor as a key regulator in arctigenin-induced gallbladder cancer senescence. + + + + 28459363 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 55 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation and KRAS amino acid substitutions seem to predict site-specific recurrence and metastasis after NSCLC surgery + + + + 27336603 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 51 + 0 + + + + + + + 18 + The contribution of EGFR, EPAC, and Ca(2+) in CDCA-induced activation of CFTR-dependent Cl(-) secretion. + + + + 27558159 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 26 + 0 + + + + + + + 18 + EGFR regulates anoikis resistance in lung cancer cells. + + + + 28081539 + + + + + + + + 2017 + 6 + 10 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 10 + 11 + 2 + 0 + + + + + + + 18 + EGF, HB-EGF, TGF-alpha and beta-Cellulin mediate EGFR nuclear translocation. + + + + 27462018 + + + + + + + + 2017 + 6 + 3 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 3 + 12 + 8 + 0 + + + + + + + 18 + EGF stimulation specifically increases the transport efficiency of newly synthesized EGFRs from the endoplasmic reticulum to the plasma membrane. + + + + 27872256 + + + + + + + + 2017 + 6 + 3 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 3 + 10 + 54 + 0 + + + + + + + 18 + Results from circular dichroism spectroscopy, size exclusion chromatography with multiangle light scattering, dynamic light scattering, analytical ultracentrifugation, and small angle X-ray scattering each provide evidence that the EGFR and HER3 C-terminal tails are intrinsically disordered with extended, non-globular structure in solution. + + + + 27872189 + + + + + + + + 2017 + 6 + 3 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 3 + 10 + 54 + 0 + + + + + + + 18 + The conformation of the EGFR transmembrane domain dimer dynamically adapts to the local membrane environment. + + + + 28291355 + + + + + + + + 2017 + 6 + 3 + 10 + 2 + 0 + + + + + + + + + 2017 + 6 + 3 + 10 + 29 + 0 + + + + + + + 18 + hypoxic tumour microenvironment may have a major role in mediating resistance against anti-EGFR strategies by downregulating EGFR molecules on tumour cells + + + + 27802455 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 12 + 6 + 0 + + + + + + + 18 + Molecular dynamics simulations of WT and mutant EGFR suggest a model in which M766T activates the kinase domain by disrupting conserved autoinhibitory interactions between M766 and hydrophobic residues in the activation segment. + + + + 27936599 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 11 + 55 + 0 + + + + + + + 18 + LPA1 plays a critical role in EGF responses and that FFA4 agonists inhibit proliferation by suppressing positive cross-talk between LPA1 and the EGF receptor + + + + 27474750 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 11 + 43 + 0 + + + + + + + 18 + EGFR p.T790M mutation is associated with tumor progression. + + + + 28170370 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 11 + 7 + 0 + + + + + + + 18 + We retrospectively reviewed 183 Japanese patients with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor-naive non-small cell lung cancer harboring EGFR mutations + + + + 27590708 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 10 + 20 + 0 + + + + + + + 18 + Biochemical and in vitro interaction studies suggest direct interference with the assembly of the wild-type ErbB-2-ErbB-3 heterodimer as the underlying mode of action. To the best of our knowledge, this is the first agent to target the TMDs of ErbB to delay tumor growth and signaling + + + + 27575020 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 10 + 18 + 0 + + + + + + + 18 + plasma cell-free DNA is a promising alternative to biopsy for EGFR testing. + + + + 28006816 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 10 + 16 + 0 + + + + + + + 18 + AZD9291 is the first and only FDA approved third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for T790M-positive advanced non-small cell patients. The resistance to AZD9291 arises after therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. [review] + + + + 27770386 + + + + + + + + 2017 + 5 + 27 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 27 + 10 + 16 + 0 + + + + + + + 18 + We observed that TKI-resistant cells have increased gene and protein expression of EMT related proteins such as Vimentin, N-Cadherin, beta-Catenin and Zeb-1, while expression of E-Cadherin, an important cell adhesion molecule, was suppressed. + + + + 27396618 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 13 + 53 + 0 + + + + + + + 18 + these data indicate PKG as an intermediary in EGFR-mediated cell death, likely via apoptotic pathway. + + + + 27381222 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 13 + 46 + 0 + + + + + + + 18 + This study identified RAB7 phosphorylation and RAB coupling protein recruitment to EGFR as switches for EGF and TGF-alpha outputs, controlling receptor trafficking, signaling duration, proliferation, and migration. + + + + 27136326 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 12 + 11 + 0 + + + + + + + 18 + IL-4-stimulated HB-EGF-dependent transactivation of EGFR in macrophages may mediate inhibitory feedback for M2 polarization and HB-EGF production, thereby inhibiting gastrointestinal tumor growth. + + + + 27507810 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 10 + 58 + 0 + + + + + + + 18 + In this preliminary study from India mutation specific IHC was used for assessment of mutation status of EGFR. Although the number tested was small, a good concordance was observed between molecular EGFR mutation and IHC expression + + + + 27241644 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 10 + 21 + 0 + + + + + + + 18 + These findings demonstrate the posttranslational regulation of Foxp3 expression by AREG in cancer patients through AREG/EGFR/GSK-3beta signaling, which could lead to Foxp3 protein degradation in Treg cells and a potential therapeutic target for cancer treatment. + + + + 27432879 + + + + + + + + 2017 + 5 + 20 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 20 + 10 + 20 + 0 + + + + + + + 18 + Osteopontin/EGFR-dependent mitosis-like condensed chromatin protected cells against radiation-induced DNA double-strand breaks and repressed putative negative regulators of stem-like properties. + + + + 28202526 + + + + + + + + 2017 + 5 + 13 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 13 + 22 + 24 + 0 + + + + + + + 18 + The aim of the study was to examine the effects of frequently used polymerase chain reaction (PCR) additives DMSO, glycerol and betaine on amplification of GC-rich epidermal growth factor receptor (EGFR) gene promoter region + + + + 27284695 + + + + + + + + 2017 + 5 + 13 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 13 + 21 + 41 + 0 + + + + + + + 18 + direct bilirubin was identified as a significant risk factor, yet total cholesterol as a protective factor, for overall survival in NSCLC patients with EGFR mutations + + + + 28006834 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 7 + 0 + 9 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations should be considered as a prognostic factor for survival of patients with pathological fractures or painful bone metastases from non-small cell lung cancer. + + + + 28385942 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 6 + 16 + 5 + 0 + + + + + + + 18 + Our population-based study of 1,081 patients with refractory, KRAS exon 2 wild-type mCRC suggests a possible OS benefit with the combination of Cmab + I compared to Pmab alone without an associated increase in toxicity.With a much larger sample size (n = 1081), our study was better powered to detect an OS difference between combination and EGFR monotherapy. + + + + 28220486 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 6 + 13 + 17 + 0 + + + + + + + 18 + EGFR and VEGF immunoexpression was superior for squamous cell carcinomas, compared to basal cell carcinomas. Regarding squamous cell carcinomas, the immunoexpression of these two markers was superior in moderate/poor differentiated forms, compared to well differentiated forms. + + + + 28174788 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 6 + 12 + 39 + 0 + + + + + + + 18 + EGFRvA isoform is more stable than EGFR because of its decreased binding to c-Cbl. + + + + 27059931 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 6 + 11 + 24 + 0 + + + + + + + 18 + RLZ-8 inhibits growth and induces apoptosis of lung cancer cells by promoting EGFR degradation. + + + + 28198003 + + + + + + + + 2017 + 5 + 6 + 10 + 2 + 0 + + + + + + + + + 2017 + 5 + 6 + 10 + 22 + 0 + + + + + + + 18 + We confirmed association of reactivity of EGFR, miR-133b, miR-140, miR-140-3p, and let-7a with CNV of EGFR and a positive association between miR-133b/let-7a and reactivity of EGFR. Age and need for postoperative radiotherapy were characterized as significant in multivariate survival analysis. + + + + 28377929 + + + + + + + + 2017 + 4 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 29 + 12 + 35 + 0 + + + + + + + 18 + Data show that genes coding for epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-MET) were directly downregulated by both microRNAs miR-1 and miR-206. + + + + 27169691 + + + + + + + + 2017 + 4 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 29 + 12 + 10 + 0 + + + + + + + 18 + EGFR mutations were more frequent in tumors with lower standardized uptake value of fluorodeoxyglucose F18. + + + + 28422979 + + + + + + + + 2017 + 4 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 29 + 11 + 5 + 0 + + + + + + + 18 + EGFR TKD mutations are associated with Head and Neck Squamous Cell Carcinoma. + + + + 28064216 + + + + + + + + 2017 + 4 + 29 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 29 + 11 + 0 + 0 + + + + + + + 18 + Although patients with de novo EGFR T790M -positive tumors appear to have a worse overall prognosis than patients with acquired T790M positive tumors, Pt-based doublet chemotherapy +/- bevacizumab is moderately effective in patients. + + + + 27655904 + + + + + + + + 2017 + 4 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 22 + 12 + 36 + 0 + + + + + + + 18 + Most gastric tumors showed low EGFR expression (mRNA and protein), whereas EGFR overexpression was related to well-differentiated gastric tumors. Germinal polymorphisms -216, -191, (CA) n IVS1, and R521K were not related to EGFR expression (mRNA or protein). + + + + 28244453 + + + + + + + + 2017 + 4 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 22 + 11 + 31 + 0 + + + + + + + 18 + findings suggest that osimertinib, a clinically-approved third-generation EGFR TKI, can reverse ABCB1-mediated MDR, which supports the combination therapy with osimertinib and ABCB1 substrates may potentially be a novel therapeutic stategy in ABCB1-positive drug resistant cancers. + + + + 27649127 + + + + + + + + 2017 + 4 + 22 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 22 + 11 + 6 + 0 + + + + + + + 18 + We report for the first time the identification and therapeutic targeting of EGFR C-terminal fusions in patients with lung cancer and document responses to the EGFR inhibitor erlotinib in 4 patients whose tumors harbored EGFR fusions. Findings from these studies will be immediately translatable to the clinic, as there are already several approved EGFR inhibitors. + + + + 27102076 + + + + + + + + 2017 + 4 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 15 + 11 + 16 + 0 + + + + + + + 18 + EGFR mutations are associated with response to chemotherapy in non-small cell lung cancer. + + + + 28184913 + + + + + + + + 2017 + 4 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 15 + 11 + 16 + 0 + + + + + + + 18 + For pN1-N2 pulmonary adenocarcinoma, Epidermal Growth Factor Receptor Ex21 mutation was associated with poorer prognosis than Ex19 mutation. Thus, EGFR mutation status should be considered when predicting prognosis. + + + + 27553497 + + + + + + + + 2017 + 4 + 15 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 15 + 10 + 17 + 0 + + + + + + + 18 + Study indicates that EGFR is involved in the regulation of PD-L1 expression and cell proliferation via the IL-6/JAK/STAT3 signaling pathway in non-small cell lung cancer (NSCLC). + + + + 27499357 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 11 + 43 + 0 + + + + + + + 18 + NMR data reveal dynamics of specific EGFR regions in the unliganded state, which are strongly reduced by ligand binding, suggesting that a reduction in conformational entropy contributes to the free energy of EGFR dimerization. + + + + 27839865 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 11 + 39 + 0 + + + + + + + 18 + The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR-PI3K-AKT signaling pathway + + + + 27221510 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 11 + 39 + 0 + + + + + + + 18 + EGFR and KRAS mutations have a predictive role on brain metastases incidence, recurrence and outcome in Caucasian Non-Small Cell Lung Cancer patients. + + + + 27999344 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 11 + 1 + 0 + + + + + + + 18 + Report cRGD-siRNA targeting of EGFR expression in gliomablastoma. + + + + 28181832 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 10 + 52 + 0 + + + + + + + 18 + Progression-free survival of L858 mutant patients was 13.75 and 7.96 months (P = 0.008), respectively. EGFR-mutant lung adenocarcinoma patients with lower EGFR gene expression had longer progression-free survival duration without interfering overall survival. + + + + 28351317 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 10 + 48 + 0 + + + + + + + 18 + Results indicated that EGFR exert effects on the initiation and progression of breast cancer through upregulating the level of CD44 and related markers of cancer stem cells and epithelial-mesenchymal transition. + + + + 27499099 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 10 + 20 + 0 + + + + + + + 18 + It suggested that ASMase mediated the 50-Hz MF-induced EGFR clustering via ceramide which was produced from hydrolyzation on lipid rafts. + + + + 26915736 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 10 + 15 + 0 + + + + + + + 18 + Survival analysis showed that the non-small cell lung carcinoma patients with enhanced expression of CK7, ELF3, EGFR, and EphB4 mRNA in peripheral blood leukocytes had poorer disease-free survival and overall survival than those without. + + + + 27827952 + + + + + + + + 2017 + 4 + 8 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 8 + 10 + 6 + 0 + + + + + + + 18 + Data show that tight junction protein 1 (TJP1) suppressed expression of the catalytically proteasome subunits LMP7 and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR/JAK1/STAT3 signaling. + + + + 27132469 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 13 + 19 + 0 + + + + + + + 18 + 15 bp deletion (c.2235_2249del; p.Glu746_Ala750del) in epidermal growth factor receptor exon 19 is found with mucin-producing gastric cancer. + + + + 27004903 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 13 + 12 + 0 + + + + + + + 18 + heterogeneous EGFR mutations are expressed in micropapillary component of lung adenocarcinomas + + + + 27046167 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 12 + 1 + 0 + + + + + + + 18 + Study suggests that maintenance therapy with low-dose erlotinib might be useful and tolerable in selected NSCLC patients harboring EGFR mutation. + + + + 28061541 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 11 + 24 + 0 + + + + + + + 18 + These results may provide one explanation for the low activity of EGFR inhibitors in clinical trials and suggest antagonism of AMPK or of AMPK-regulated metabolic alterations as a promising approach to enhance their therapeutic efficacy. + + + + 27121290 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 11 + 6 + 0 + + + + + + + 18 + study revealed that the EGFR mutations rate in Jordanian patients with adenocarcinoma of the lung was higher than in African-American, and some white Caucasian patients, and was lower than in patients in East Asia, and other countries of South Asia + + + + 27461620 + + + + + + + + 2017 + 4 + 1 + 10 + 2 + 0 + + + + + + + + + 2017 + 4 + 1 + 10 + 38 + 0 + + + + + + + 18 + the EGFR mutations in lung adenocarcinoma patients were independently correlated with distant metastases + + + + 27888377 + + + + + + + + 2017 + 3 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 25 + 12 + 43 + 0 + + + + + + + 18 + downregulation of HCRP1 is a valuable prognostic factor involved in EGFR regulation and acquisition of the mesenchymal phenotype of hepatocellular carcinoma cells. + + + + 28122307 + + + + + + + + 2017 + 3 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 25 + 12 + 24 + 0 + + + + + + + 18 + results showed that survivin genetic variants were related to EGFR mutation in lung adenocarcinoma patients and might contribute to pathological development to NSCLC. + + + + 27994498 + + + + + + + + 2017 + 3 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 25 + 11 + 32 + 0 + + + + + + + 18 + Determination of EGFR gene somatic mutations in tissues and plasma of patients with advanced non-small cell lung cancer + + + + 28026806 + + + + + + + + 2017 + 3 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 25 + 10 + 7 + 0 + + + + + + + 18 + Our results indicate that enhanced chemosensitivity of cells lacking wild-type p53 function is because of elevated levels of EGFR which activates ERK. + + + + 28229963 + + + + + + + + 2017 + 3 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 18 + 12 + 5 + 0 + + + + + + + 18 + Results showed that IGF1R genetic variants are related to EGFR mutation in female lung adenocarcinoma patients and may be a predictive factor for tumor lymph node metastasis in Taiwanese patients with non-small-cell lung carcinoma. + + + + 27213344 + + + + + + + + 2017 + 3 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 18 + 11 + 6 + 0 + + + + + + + 18 + Anti-epithelial growth factor receptor(EGFR) targeted therapy emerged as a potential treatment option. In recent years many trials were conducted to find the optimum treatment option with the combination of these targeted agents. + + + + 27160750 + + + + + + + + 2017 + 3 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 18 + 11 + 0 + 0 + + + + + + + 18 + KLF6 acts as a tumor suppressor in CMM cells and miR-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR inactivation and p21 upregulation. + + + + 27779691 + + + + + + + + 2017 + 3 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 18 + 10 + 27 + 0 + + + + + + + 18 + EGFR Del 19 may promote Fn14 and JAK1/STAT1 expression in NSCLC. + + + + 27350337 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 51 + 0 + + + + + + + 18 + our results implicate GPRC5A as a tumor suppressor in breast cancer cells, and GPRC5A exerts its tumor-suppressive function by inhibiting EGFR and its downstream pathway + + + + 27599526 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 40 + 0 + + + + + + + 18 + Authors found that urinary cell-free DNA yielded a close agreement of 92% on epidermal growth factor receptor mutation status when compared to primary tissue at baseline, and of 99% epidermal growth factor receptor mutation status when compared to plasma samples at different time points. + + + + 28222666 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 37 + 0 + + + + + + + 18 + Non-smoking patients with EGFR mutant adenocarcinoma had the highest benefit from TKI treatment. + + + + 27105879 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 7 + 0 + + + + + + + 18 + Paralog of TAZ (YAP) expression can be upregulated by TAZ inhibition which leads to EGFRI resistance. + + + + 27373987 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 6 + 0 + + + + + + + 18 + Activating EGFR mutations were found in 14.1% of all tumors, whereas KRAS mutations were found in 30.5% of all tumors. + + + + 27373829 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 11 + 6 + 0 + + + + + + + 18 + Data indicate that epidermal growth factor receptor (EGFR) mutations were frequently observed in the non-emphysema group, which is characterized by non-smoking-associated lung cancer. + + + + 28179328 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 10 + 52 + 0 + + + + + + + 18 + Patients with advanced non-squamous NSCLC harboring asensitive EGFR mutation were included in this study. + + + + 27126186 + + + + + + + + 2017 + 3 + 11 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 11 + 10 + 36 + 0 + + + + + + + 18 + Ground glass opacity proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation. + + + + 26787602 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 12 + 44 + 0 + + + + + + + 18 + High EGFR expression is associated with prostate cancer. + + + + 27524492 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 11 + 53 + 0 + + + + + + + 18 + Inhibition of EGFR and KRAS downstream with a P13K/Akt inhibitor could be useful for treating NSCLC. + + + + 27121230 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 11 + 33 + 0 + + + + + + + 18 + BIM deletion polymorphism does not account for intrinsic resistance to EGFR-TKI in Patients With Lung Adenocarcinoma + + + + 27077907 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 11 + 21 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 27468867 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 10 + 53 + 0 + + + + + + + 18 + High EGFR expression is associated with esophageal squamous cell carcinoma. + + + + 26810066 + + + + + + + + 2017 + 3 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 3 + 4 + 10 + 36 + 0 + + + + + + + 18 + his study aimed to elucidate the association of the content of mutant epidermal growth factor receptor (EGFR) deoxyribonucleic acid (DNA) with the treatment response to EGFR-tyrosine kinase inhibitor (TKI) and survival in patients with lung cancer + + + + 27368002 + + + + + + + + 2017 + 2 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 25 + 11 + 55 + 0 + + + + + + + 18 + EGFR mutation is associated with lung adenocarcinomas. + + + + 26882436 + + + + + + + + 2017 + 2 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 25 + 11 + 12 + 0 + + + + + + + 18 + miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma. + + + + 27094723 + + + + + + + + 2017 + 2 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 25 + 10 + 9 + 0 + + + + + + + 18 + Cytological samples can be used successfully to determine the EGFR mutation status in NSCLC patients providing information for targeted therapy at an early stage of the disease. + + + + 26990359 + + + + + + + + 2017 + 2 + 25 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 25 + 10 + 7 + 0 + + + + + + + 18 + EGFR Mutation is associated with response to chemotherapy in Nonsquamous Nonsmall Cell Lung Cancer. + + + + 27509958 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 12 + 28 + 0 + + + + + + + 18 + Increased miR-23a level may be used to predict the presence and severity of coronary lesions in patients with coronary artery disease. MiR-23a regulates the vasculogenic potential of endothelial progenitor cells by targeting EGFR. + + + + 27085964 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 12 + 18 + 0 + + + + + + + 18 + C23 on the cell surface may be a kind of indispensable component in activation of EGFR signaling, by which C23 can participate in the growth and invasion of cervical tumors + + + + 26254615 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 44 + 0 + + + + + + + 18 + Propofol could enhance the anti-tumor effect of cisplatin through EGFR/JAK2/STAT3 pathway. + + + + 28011380 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 39 + 0 + + + + + + + 18 + Smoking during treatment is a negative prognostic factor in metastatic lung adenocarcinoma with an EGFR mutation + + + + 27371767 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 39 + 0 + + + + + + + 18 + this is the first study showing an association of EGFR and ErbB2 serum levels with glioma more than a decade before diagnosis + + + + 26906551 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 38 + 0 + + + + + + + 18 + CTCs are a feasible and highly specific biomarker for detecting the EGFR mutation status in NSCLC patients. + + + + 27893656 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 37 + 0 + + + + + + + 18 + The importance of mutations in EGFR gene. + + + + 26762413 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 24 + 0 + + + + + + + 18 + the present study indicates the potential value of SNP rs712829 in the promoter region of the EGFR gene and SNP rs1130214 in the AKT1 gene as novel prognostic markers in NSCLC patients treated with EGFR-TKIs. + + + + 26269114 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 23 + 0 + + + + + + + 18 + We found that increased SIAH and EGFR expression correlated with advanced pathological stage and aggressive molecular subtypes. Both SIAH expression post-NST and NST-induced changes in EGFR expression in invasive mammary tumors are associated with tumor regression and increased survival. + + + + 27569656 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 16 + 0 + + + + + + + 18 + miR-520b/e acts as a tumor suppressor by regulating EGFR in gastric cancer. + + + + 27997901 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 11 + 4 + 0 + + + + + + + 18 + Src and EGFR are involved in the regulation of cellular invasiveness by Bcl-2 proteins + + + + 26286833 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 59 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with Recurrent Glioblastomas. + + + + 27797218 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 58 + 0 + + + + + + + 18 + inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR/ERK/AP-1 pathway. + + + + 27220321 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 55 + 0 + + + + + + + 18 + EGFR mutation rate detected in pleural effusion specimens from patients with advanced lung adenocarcinoma is similar to that detected in tumor tissue samples. + + + + 27173189 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 53 + 0 + + + + + + + 18 + Near-infrared (NIR) irradiation induced the upregulated expression of EGFR in human corneal cells. Since over half of the solar energy reaching the Earth is in the NIR region, which cannot be adequately blocked by eyewear and thus can induce eye damage with intensive or long-term exposure, protection from both UV and NIR radiation may prevent changes in gene expression and in turn eye damage. + + + + 27536083 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 35 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in non-small cell lung cancer. + + + + 27473086 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 29 + 0 + + + + + + + 18 + The specific FDG uptake value could be considered to effectively predict EGFR mutation status of NSCLC patients by considering smoking history and primary tumor size when genetic tests are not available. + + + + 27472739 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 29 + 0 + + + + + + + 18 + Genomic DNA alterations were the main reason for the high expression of EGFR in glioblastoma multiforme tumor cells. miRNAs targeting EGFR in GBM microvascular proliferation were upregulated and was one of the reasons for the lack of expression of EGFR in GBM microvascular proliferation. + + + + 26857280 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 26 + 0 + + + + + + + 18 + ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC by conferring anchorage independence through EGFR-dependent FAK-AKT activation. + + + + 26996299 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 24 + 0 + + + + + + + 18 + cSMART assay was highly reliable and accurate for plasma EGFR genotyping. Based on discordance trends, tumour heterogeneity was suspected to be the major factor preventing a concordant diagnosis in matching samples + + + + 27071701 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 24 + 0 + + + + + + + 18 + results revealed that there are consistent and widespread expressions of EGFR in neuroblastoma tissues as well as in neuroblastoma cell lines, suggesting that it is possible to develop future treatment strategies of neuroblastoma by targeting at the EGFR + + + + 27353319 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 18 + 0 + + + + + + + 18 + tumor-associated leukocytes of positive lymph node breast cancer patients secrete cytokines that have the potency to induce Epithelial-mesenchymal transition (EMT) process via activation of p-EGFR(Tyr845) and p-NF-kappaB/p65(ser276) clues. + + + + 27329104 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 17 + 0 + + + + + + + 18 + The inhibition of cell proliferation and invasion was observed in the ADAM17 knockdown cells, which was associated with modulation of the EGFR signalling pathway. + + + + 27878499 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 15 + 0 + + + + + + + 18 + The EGFR gene polymorphism rs1050171 defines, independently of RAS mutational status, a sub-population of 11 % of patients with a better clinical outcome after anti-EGFR treatment. Median PFS for patients with the GG genotype was 10.17 months compared to 5.37 of those with AG + AA genotypes. + + + + 26666825 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 15 + 0 + + + + + + + 18 + EGFR SNPS -216G>T, -191C>A, and 181946C>T were measured in Serbian non-small cell lung cancer (NSCLC) patients,compared controls. There was a significant association between -216GG genotype and NSCLC patients among smokers. Carriers of -216GG genotype had a higher risk than noncarriers (GT and TT) for developing NSCLC. + + + + 26846215 + + + + + + + + 2017 + 2 + 18 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 18 + 10 + 14 + 0 + + + + + + + 18 + these data suggest that Lupeol may act as a potent inhibitor of the EGFR signaling in oral squamous cell carcinoma and therefore imply its role in triggering antitumor efficacy. + + + + 27206736 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 12 + 44 + 0 + + + + + + + 18 + In Panc-1 cells, overexpression of E-cadherin activated the phosphorylation of EGFR and increased the cell sensitivity to erlotinib. In Capan1 cells, knocking down E-cadherin decreased the expression of phosphorylated EGFR, and these cells did not respond to erlotinib. + + + + 26493999 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 12 + 30 + 0 + + + + + + + 18 + EGFR expression was down-regulated in the presence of the compounds. + + + + 27644655 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 12 + 30 + 0 + + + + + + + 18 + A considerable number of TNBC co-expresses E-cadherin and P-cadherin, while membranous localization of beta-catenin may predict patient outcome in an EGFR-dependent manner. This novel interaction seems worthy for validating with regards to its biological and clinical relevance + + + + 27127145 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 11 + 52 + 0 + + + + + + + 18 + endophilin B1 mediated the biological function of EGFR in cancer cell proliferation through regulating the EGFR endocytic trafficking and downstream signaling. + + + + 27609472 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 11 + 48 + 0 + + + + + + + 18 + The aim of this study was to assess the effectiveness and accuracy of blood-based circulating-free tumor DNA on testing epidermal growth factor receptor (EGFR) gene mutations. + + + + 27370697 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 11 + 42 + 0 + + + + + + + 18 + The EGFR/collagen IV ratio was predictive and was an independent prognostic indicator in TNBC. + + + + 26385773 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 11 + 42 + 0 + + + + + + + 18 + High EGFR Expression is associated with poor Radiosensitivity in Cervical Adenocarcinoma. + + + + 27268625 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 11 + 21 + 0 + + + + + + + 18 + PCDH-17 inhibited metastasis via EGFR/MEK/ERK signaling pathway. + + + + 26386721 + + + + + + + + 2017 + 2 + 4 + 10 + 2 + 0 + + + + + + + + + 2017 + 2 + 4 + 10 + 40 + 0 + + + + + + + 18 + (131)I-antiEGFR-BSA-PCL suppressed the development of xenografted colorectal cancer in nude mice, thereby providing a novel candidate for receptor-mediated targeted radiotherapy. + + + + 27076760 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 11 + 21 + 0 + + + + + + + 18 + n this review, we summarize the current guidelines for anti-EGFR therapy, revisit the roles of pathologists in an era of precision cancer medicine, demonstrate the transition from traditional "one test-one drug" assays to multiplex assays, especially by using next-generation sequencing platforms in the clinical diagnostic laboratories + + + + 27699178 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 11 + 21 + 0 + + + + + + + 18 + Data show that anti-human CD47 antibody B6H12 decreased expression of epidermal growth factor receptor (EGFR) and the stem cell transcription factors. + + + + 26840086 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 11 + 19 + 0 + + + + + + + 18 + EGFR Mutation is associated with lung Cancer. + + + + 26925681 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 11 + 8 + 0 + + + + + + + 18 + Shorter CA repeats in intron 1 of EGFR are associated with EGFR mutations and better clinical outcomes of tyrosine kinase inhibitors-treated patients with NSCLC. + + + + 27259328 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 10 + 42 + 0 + + + + + + + 18 + patients with BIM-g had significantly shorter progression-free survival than those without BIM-gamma (median: 304 vs. 732 days; p=0.023). CONCLUSION: Expression of BIM-gamma mRNA and BIM deletion polymorphism were strongly associated. BIM-gamma overexpression may have a role in apoptosis related to EGFR-tyrosine kinase inhibitor + + + + 27807070 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 10 + 23 + 0 + + + + + + + 18 + Retrospective demographic, treatment and outcome data were collected on patients with: stage III/IV NSCLC and either del19 or L858R, receiving an EGFR TKI as first-line treatment. Patients with exon del19 did not have a significantly longer OS with first-generation TKIs. + + + + 27466542 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 10 + 17 + 0 + + + + + + + 18 + The EGFR mutation rate was 48.7% in NSCLCs. + + + + 27039821 + + + + + + + + 2017 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 28 + 10 + 15 + 0 + + + + + + + 18 + EGFR gene copy number gain correlated with poor prognosis in gastric cancer patients. + + + + 25487305 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 58 + 0 + + + + + + + 18 + ALK fusions occur in approximately 5% of lung adenocarcinoma and typically occur in a mutually exclusive manner to EGFR mutations. + + + + 27776643 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 43 + 0 + + + + + + + 18 + Validation of Real-time PCR for detection of L858R EGFR mutation. + + + + 27029725 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 43 + 0 + + + + + + + 18 + This nanocomposite takes advantage of the epidermal growth factor receptor (EGFR) active targeting of the ligand in addition to the photoluminescence properties of SiNPs for bioimaging purpose + + + + 27007883 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 39 + 0 + + + + + + + 18 + EGFR positive status had no significant prognostic impact in terms of survival in advanced gastric cancer patients. + + + + 25682441 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 25 + 0 + + + + + + + 18 + The patients with compound mutation of EGFR showed shorter overall survival than those with simple mutation.s + + + + 26785607 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 17 + 0 + + + + + + + 18 + EGFR mutation is associated with non small cell lung cancer. + + + + 26780337 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 14 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in metastatic pulmonary adenocarcinoma. + + + + 25976428 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 11 + 8 + 0 + + + + + + + 18 + Activating HRAS, KRAS and EGFR mutations play a major role in the pathogenesis of sporadic SGH. These results support the concept that SGH is a true benign neoplasm rather than a reactive hyperplasia. + + + + 26804118 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 10 + 52 + 0 + + + + + + + 18 + or patients with non-small cell lung cancer with a EGFR mutation and an anaplastic lymphoma kinase mutation(ALK) with brain metastases, several agents have shown intracranial activity. Lapatinib has been tested for patients with brain metastases from breast cancer harboring a HER2 mutation. molecular targeted therapies have shown efficacy in BRAF-positive melanoma brain metastasis + + + + 27249714 + + + + + + + + 2017 + 1 + 14 + 10 + 2 + 0 + + + + + + + + + 2017 + 1 + 14 + 10 + 20 + 0 + + + + + + + 18 + EGFR mutations and amplifications are not molecular events in the pathogenesis of borderline ovarian tumors. + + + + 26870997 + + + + + + + + 2016 + 12 + 31 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 31 + 12 + 0 + 0 + + + + + + + 18 + GBP1 expression is elevated in human Glioblastoma multiforme tumors and positively correlates with EGFRvIII status in Glioblastoma multiforme specimens, and its expression is inversely correlated with the survival rate of Glioblastoma multiforme patients. Taken together, these results reveal that GBP1 may serve as a potential therapeutic target for Glioblastoma multiforme with EGFRvIII mutation. + + + + 26848767 + + + + + + + + 2016 + 12 + 31 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 31 + 11 + 51 + 0 + + + + + + + 18 + EGFR T790M circulating tumor DNA can be detected in plasma before and after progressive disease as a poor prognostic factor. + + + + 26867973 + + + + + + + + 2016 + 12 + 31 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 31 + 11 + 27 + 0 + + + + + + + 18 + The findings suggest the coal emissions could influence the response of EGFR in lung cancer cells in Chinese households that burn coal. + + + + 27613327 + + + + + + + + 2016 + 12 + 31 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 31 + 10 + 45 + 0 + + + + + + + 18 + EGFR role in non-small cell lung cancer resistance to sorafenib + + + + 27090797 + + + + + + + + 2016 + 12 + 31 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 31 + 10 + 7 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small-cell lung cancer. + + + + 26789109 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 11 + 52 + 0 + + + + + + + 18 + The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. + + + + 26999786 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 11 + 18 + 0 + + + + + + + 18 + We present multiplexed RO assays for an IGF1R-EGFR bispecific antibody (Bs-Ab) and a CTLA4-Ig recombinant fusion protein to demonstrate key considerations for accurate RO assessment. + + + + 26332491 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 11 + 18 + 0 + + + + + + + 18 + This study indicates that the likelihood of nonadenocarcinoma patients having EGFR mutant tumors may differ according to brain metastasis and squamous cell histology. + + + + 27072258 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 11 + 8 + 0 + + + + + + + 18 + Baseline serum CEA levels can serve as predictive factors for the treatment of EGFR-TKI in non-small cell lung cancer patients harboring EGFR mutations. + + + + 27072247 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 11 + 8 + 0 + + + + + + + 18 + EGFR mutations are associated with treatment response in Non-small cell lung cancer. + + + + 26755650 + + + + + + + + 2016 + 12 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 24 + 10 + 35 + 0 + + + + + + + 18 + It shows promise as a therapeutic agent, especially for use against tumors EGFR and/or VEGFR2 over-expressing malignancies. + + + + 26671532 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 12 + 7 + 0 + + + + + + + 18 + TGF-beta and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through reactive oxygen species-mediated activation of Nrf2 and EGFR. + + + + 26904167 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 12 + 2 + 0 + + + + + + + 18 + EGFR inhibitors induced TNF-alpha via PPARgamma/NFkappaB signaling pathway resulting in papulopustular rash. + + + + 26742624 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 48 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor Mutation is associated with response to chemotherapy in Small Cell Lung Cancer. + + + + 26683257 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 37 + 0 + + + + + + + 18 + Results suggest that GPCR transactivation of the EGFR may play an important role in lung cancer cell proliferation. [review] + + + + 25563590 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 28 + 0 + + + + + + + 18 + Data show that CD133 overexpression resulted in decreased EGF and EGFR expression, increased telomerase reverse transcriptase (TERT) expression, and increased Akt phosphorylation. + + + + 26646272 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 23 + 0 + + + + + + + 18 + patients with wild-type EGFR might not benefit from first-line treatment of advanced Non-Small-cell Lung Cancer with gefitinib + + + + 26809984 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 18 + 0 + + + + + + + 18 + Forty-nine paired tissues with both primary adenocarcinoma of lung and matched brain metastasis were collected. Thirteen patients (26.5%) were discordant for the status of EGFR between primary and metastatic sites. K-ras gene could be checked in paired specimens from 33 patients, thirteen patients (39.6%) were discordant for the status of K-ras. + + + + 27070580 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 18 + 0 + + + + + + + 18 + This study study identified clinicopathological factors related to postoperative seizure in high-grade gliomas and found two predictive biomarkers of postoperative seizure: MGMT and EGFR + + + + 26808114 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 18 + 0 + + + + + + + 18 + These findings suggest that ezrin-EGFR interaction augments oncogenic functions of EGFR and that targeting ezrin may provide a potential novel approach to overcome erlotinib resistance in non-small cell lung cancer cells + + + + 26936397 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 11 + 1 + 0 + + + + + + + 18 + results reveal a mechanism whereby JAK2 inhibition overcomes acquired resistance to EGFR inhibitors and support the use of combination therapy with JAK and EGFR inhibitors for the treatment of EGFR-dependent NSCLC. + + + + 27025877 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 59 + 0 + + + + + + + 18 + overexpression of phospho-ALK and alternative receptor tyrosine kinases such as phospho-EGFR, phospho-HER3, and phospho-IGFR-1R was observed in both resistant cell lines. Additionally, NRG1, a ligand for HER3, is upregulated and responsible for resistance by activating the EGFR family pathways through the NRG1-HER3-EGFR axis. + + + + 26992917 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 50 + 0 + + + + + + + 18 + Results show the direct regulation of CAGE expression by HDAC3 and that HDAC3-CAGE axis regulates the activation of EGFR. HDAC3 targets CAGE to regulate the tumorigenic potential and angiogenic potential of cancer cells. + + + + 26883907 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 44 + 0 + + + + + + + 18 + A very high percentage (72.4%, 21/29) of NSCLC patients with EGFR mutations with PR demonstrates early radiological response to EGFR-TKIs + + + + 25179728 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 25 + 0 + + + + + + + 18 + In conclusion, 8(9)Zr-DFO-ZEGFR:2377 is a potential probe for PET imaging of EGFR-expression in vivo. + + + + 26847636 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 19 + 0 + + + + + + + 18 + Sixteen (14%) of the 115 samples were mutated for EGFR and 99 (86%) showed wild-type EGFR status. + + + + 25757141 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 13 + 0 + + + + + + + 18 + EGFR kinase domain mutation is associated with response to chemotherapy in lung cancers. + + + + 26654941 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 12 + 0 + + + + + + + 18 + The cytologic tumor marker c-CYFRA was positively associated with EGFR mutations in non-small cell lung cancer (NSCLC). EGFR mutation-positive NSCLCs have relatively lower glycolysis compared with NSCLCs without EGFR mutation + + + + 26979333 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 11 + 0 + + + + + + + 18 + lP-EGF was internalized by an active and selective mechanism through EGFR without receptor activation. Oxaliplatin LP-EGF decreased IC50 between 48 and 13% in cell EGFR+. + + + + 26892017 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 11 + 0 + + + + + + + 18 + Data show that apoptotic cell death by esculetin was associated with inhibition of the EGFR/PI3K/Akt signaling pathway and the decreased expression of nucleophosmin (NPM). + + + + 26447856 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 10 + 0 + + + + + + + 18 + The use of complementary approaches may provide the most complete assessment of each patient's cancer, which should be validated in predicting response to EGFR T790M-targeted inhibitors. + + + + 26446944 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 9 + 0 + + + + + + + 18 + case report and case series on germline mutations in patients with lung adenocarcinoma + + + + 26700910 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 7 + 0 + + + + + + + 18 + Our findings indicate that FOXO3a is a significant factor in EGFR mutation-independent gefitinib resistance and the stemness of lung cancer, and suggest that targeting the NF-kappaB/miR-155/FOXO3a pathway has potential therapeutic value in lung cancer with the acquisition of resistance to EGFR-TKIs. + + + + 27091996 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 6 + 0 + + + + + + + 18 + findings identify USP9X as a novel regulator of EGFR endocytosis + + + + 26748853 + + + + + + + + 2016 + 12 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 12 + 17 + 10 + 5 + 0 + + + + + + + 18 + These results indicate that in response to Pseudomonas aeruginosa or flagellin, EGFR associates with and tyrosine phosphorylates MUC1-CT in primary normal human bronchial epithelial cells, leading to increased MUC1-CT association with TLR5 + + + + 26645913 + + + + + + + + 2016 + 11 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 19 + 11 + 49 + 0 + + + + + + + 18 + GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR interactive signaling. + + + + 27010855 + + + + + + + + 2016 + 11 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 19 + 10 + 53 + 0 + + + + + + + 18 + LINC01225 could bind to epidermal growth factor receptor (EGFR) and increase the protein level of EGFR, and subsequently fine tune the EGFR/Ras/Raf-1/MEK/MAPK signaling pathway. + + + + 26938303 + + + + + + + + 2016 + 11 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 19 + 10 + 7 + 0 + + + + + + + 18 + DNA sequencing detected EGFR mutations with high frequency and revealed a broad spectrum of mutation type in Vietnamese patients with non-small cell lung cancer + + + + 26707566 + + + + + + + + 2016 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 12 + 11 + 30 + 0 + + + + + + + 18 + A novel NHERF1 mutation in human breast cancer cells inactivates inhibition of EGFR signaling by NHERF1 promoting disease progression. + + + + 26977012 + + + + + + + + 2016 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 12 + 10 + 35 + 0 + + + + + + + 18 + Data indicate that epidermal growth factor receptor (EGFR) mutant lung cancer as a vitamin D-responsive disease and diet-derived 25-hydroxyvitamin D3 (25D3) as a direct vitamin D receptor (VDR) agonist and therapeutic agent. + + + + 26654942 + + + + + + + + 2016 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 12 + 10 + 34 + 0 + + + + + + + 18 + Authors' experiments argue against ARNO being a robust modifier of EGFR catalytic activity. + + + + 27203102 + + + + + + + + 2016 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 12 + 10 + 29 + 0 + + + + + + + 18 + In the case of urgency of starting treatment, EGFR mutation testing may be avoided in those patients who are negative for these IHC markers and can be started on chemotherapy. + + + + 26905105 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 12 + 3 + 0 + + + + + + + 18 + Data show that EGF receptor (EGFR) is involved in the microRNA miR-107 pathogenesis of hepatocellular carcinoma (HCC) through cytoplasmic polyadenylation element binding protein 3 (CPEB3). + + + + 26497556 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 12 + 0 + 0 + + + + + + + 18 + Results suggest, a potential role for PIK3CA, VEGFR2, RET and FGFR2 as therapeutic targets in EGFR non-mutated NSCLC that requires further clinical validation. + + + + 26853422 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 11 + 41 + 0 + + + + + + + 18 + A concurrent PIK3CA mutation is a poor prognostic factor in patients with advanced EGFR-mutant or KRAS-mutant lung adenocarcinomas. + + + + 26334752 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 11 + 35 + 0 + + + + + + + 18 + Concurrent CRT resulted in shorter progression-free survival in EGFR-mutant stage III adenocarcinoma patients than in wild-type patients, mainly because of distant metastasis relapse, regardless of better local control. + + + + 26743855 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 11 + 28 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in lung cancer. + + + + 26716903 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 11 + 4 + 0 + + + + + + + 18 + Overexpression of wildtype EGFR is tumorigenic in non-small cell lung cancer. + + + + 26646697 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 11 + 2 + 0 + + + + + + + 18 + Data sustain EGFR as the key player in the pathogenesis of HNSCCs, but its diagnostic value may be improved by association with other prognostic or therapeutic markers. + + + + 26708602 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 24 + 0 + + + + + + + 18 + This study showed that CTX III inhibitory effect on EGF-evoked invasion of MDA-MB-231 cells is mediated through suppressing EGF/EGFR activation and EMT process. + + + + 26774845 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 24 + 0 + + + + + + + 18 + This review analyzes randomized clinical trials of EGFR inhibition in NSCLC and meta-analyses of these trials, with a focus on patients with squamous histology + + + + 26768483 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 20 + 0 + + + + + + + 18 + Noninvasive monitoring of the predominance of tumors harboring the secondary T790M mutation in the activating mutation in EGFR gene is necessary for precise and effective treatment of lung adenocarcinoma. + + + + 26768482 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 20 + 0 + + + + + + + 18 + EGFR mutation is associated with response to radiosurgery in brain metastasis. + + + + 26520640 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 17 + 0 + + + + + + + 18 + this tracer has the potential to be used to determine cetuximab targeting of tumors and possibly to non-invasively monitor the response to EGFR-inhibitor treatment. + + + + 26242487 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 16 + 0 + + + + + + + 18 + EGFR is frequently overexpressed in ependymomas. Other mechanisms than amplification of the EGFR gene appear to contribute to EGFR overexpression in most cases. + + + + 26686534 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 14 + 0 + + + + + + + 18 + Suggest that IGF1R plays an important role in acquired drug resistance against EGFR-TKIs by inducing epithelial mesenchymal transformation in non-small cell lung cancer. + + + + 26554308 + + + + + + + + 2016 + 11 + 5 + 10 + 2 + 0 + + + + + + + + + 2016 + 11 + 5 + 10 + 8 + 0 + + + + + + + 18 + miR-7 may function by interfering with EGFR mRNA translation, but not degradation + + + + 26708917 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 12 + 5 + 0 + + + + + + + 18 + the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum + + + + 26676887 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 11 + 58 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in non-small cell lung cancer. + + + + 26096169 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 11 + 23 + 0 + + + + + + + 18 + The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer. + + + + 26823874 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 11 + 21 + 0 + + + + + + + 18 + CD73 promotes the growth of human colorectal cancer cells through EGFR and the b-catenin/cyclin D1 signaling pathway. CD73 may be used as a valuable biomarker of colorectal cancer. + + + + 26708311 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 10 + 56 + 0 + + + + + + + 18 + The P2RY2 receptor induces carcinoma cell migration and epithelial-mesenchymal transition through cross-talk with EGFR. + + + + 26443721 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 10 + 25 + 0 + + + + + + + 18 + EGFR exon 19 deletions were associated with better outcomes in non-small cell lung cancer, despite a higher percentage of brain metastases + + + + 26645830 + + + + + + + + 2016 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 29 + 10 + 19 + 0 + + + + + + + 18 + Chromogenic Assay for Lung Cancer-Related EGFR Exon 19 Hotspot Deletion Mutations. + + + + 26544543 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 12 + 32 + 0 + + + + + + + 18 + four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR + + + + 26718882 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 12 + 10 + 0 + + + + + + + 18 + in non-small cell lung carcinoma patients, EGFR mutations were detected in exon 19 in 32 patients, exon 20 in 16, and exon 21 in 15; no mutations were observed in exon 18 + + + + 26514492 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 12 + 3 + 0 + + + + + + + 18 + EGFR is transcriptionally activated by G protein-coupled receptors. (Review) + + + + 26771606 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 11 + 58 + 0 + + + + + + + 18 + these data indicate that activation of EGFR enhanced the expression of P2X7R in neuroblastoma cells lacking trophic support, being PI3K/Akt/PKC signaling pathway and Sp1 mediating this pro-survival outcome + + + + 26687764 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 11 + 57 + 0 + + + + + + + 18 + Our results suggested that smoking status could influence not only the frequency but also the spectrum of EGFR mutations. These findings provide a clue for further investigation of EGFR mutagenesis. + + + + 26474957 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 11 + 31 + 0 + + + + + + + 18 + mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant non-small-cell lung cancer. + + + + 26639561 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 11 + 28 + 0 + + + + + + + 18 + CD24 regulates EGFR signaling by inhibiting EGFR internalization and degradation in a RhoA-dependent manner in gastric cancer cells. + + + + 26830684 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 11 + 3 + 0 + + + + + + + 18 + Compared with other predominant subtypes with EGFR mutations, the microenvironment of SPA with EGFR mutations is characterized by cancer cells with higher invasive and immune evasion potential and more abundant stromal cells with tumor-promoting functions, which would contribute to the more aggressive behavior of SPA. + + + + 26711928 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 10 + 54 + 0 + + + + + + + 18 + Mucin production via the TLR3-epidermal growth factor receptor (EGFR) pathway in airway epithelial cells, which is the pathogenesis of COPD. + + + + 26100173 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 10 + 50 + 0 + + + + + + + 18 + EGFR mutation is associated with Small Cell Lung Cancer Transformation. + + + + 26762749 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 10 + 44 + 0 + + + + + + + 18 + Data show that epidermal growth factor receptor (EGFR)-mediated signaling in mutant KRAS protein (K-ras) pancreatic cancer cells does not follow canonical mitogen-activated protein kinase (MAPK) signaling. + + + + 26262587 + + + + + + + + 2016 + 10 + 22 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 22 + 10 + 42 + 0 + + + + + + + 18 + The existence of a tight association between SHP2 and EGFR expression in tumors and cell lines further suggested the importance of SHP2 in EGFR expression. + + + + 26728598 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 44 + 0 + + + + + + + 18 + This ubiquitin-mediated switch in EGFR trafficking is a uniquely suited solution to suppress spontaneous activation while maintaining responsiveness to EGF. + + + + 26609808 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 18 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor Mutations in Serum is associated with response to Erlotinib for Advanced Non-Small-Cell Lung Cancer. + + + + 26336854 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 15 + 0 + + + + + + + 18 + Study shows that Srx plays a critical oncogenic role to promote cell invasion and metastasis, which is at least partially due to its stimulation of the MAPK pathway through EGFR deacetylation. + + + + 26290602 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 14 + 0 + + + + + + + 18 + Results showed that EBP50 specifically scaffolds the interaction of PTEN with EGFR and enhances the inhibition of PTEN on EGF-induced AKT activation. These results elucidated a novel mechanism regulating EGF-induced AKT signaling. + + + + 26531778 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 12 + 0 + + + + + + + 18 + Our data imply that at sites of tissue damage, when inflammatory mediators are present, for example in lungs of COPD patients, MSCs become more potent inducers of repair, in addition to their well-known immune-modulatory properties. + + + + 26753875 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 12 + 0 + + + + + + + 18 + The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR). + + + + 26176268 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 12 + 4 + 0 + + + + + + + 18 + Findings of frequent mutations in CDKN2A, NOTCH1, PIK3CA, and EGFR (all in excess of 20%) point to potential therapeutic avenues. Trials of targeted therapies directed toward these mutations should be explored. + + + + 26670666 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 11 + 50 + 0 + + + + + + + 18 + plasma EGFR mutation status before tyrosine kinase inhibitors therapy might be of prognostic significance for TKIs-treated non-small cell lung cancer patients with tumor tissue EGFR mutation + + + + 26722512 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 11 + 41 + 0 + + + + + + + 18 + UCH-L1 plays a crucial role in modulating the degradation of EGFR and promoting malignant properties in multi-drug resistant breast cancer + + + + 26722437 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 11 + 27 + 0 + + + + + + + 18 + EGFR Mutations are associated with Non-Small-Cell Lung Cancer. + + + + 26387039 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 11 + 12 + 0 + + + + + + + 18 + EGFR and KRAS Mutations are associated with ALK-Positive Lung Adenocarcinomas. + + + + 26381283 + + + + + + + + 2016 + 10 + 8 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 8 + 11 + 8 + 0 + + + + + + + 18 + PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs. + + + + 26850110 + + + + + + + + 2016 + 10 + 1 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 1 + 12 + 36 + 0 + + + + + + + 18 + MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells by inactivating Akt and Erk1/2 signaling and targeting EGFR. + + + + 26617770 + + + + + + + + 2016 + 10 + 1 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 1 + 11 + 43 + 0 + + + + + + + 18 + use of sorafenib has been ineffective in the management of advanced Colorectal cancer (CRC) patients with KRAS mutation, combination of selective BRAF inhibitors plus EGFR inhibitors may represent a good therapeutic strategy in BRAF-mutant CRC. + + + + 26616508 + + + + + + + + 2016 + 10 + 1 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 1 + 10 + 57 + 0 + + + + + + + 18 + mEGFR are associated with higher response rate (RR) to brain metastasis radiotherapy than wild-type EGFR/RAS or mKRAS. + + + + 26616848 + + + + + + + + 2016 + 10 + 1 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 1 + 10 + 57 + 0 + + + + + + + 18 + Findings indicate the role of CMTM7 protein in the regulation of epidermal growth factor receptor (EGFR)-AKT proto-oncogene protein signaling in tumor cells, and as a molecule related to Rab5 GTP-binding protein activation. + + + + 26528697 + + + + + + + + 2016 + 10 + 1 + 10 + 2 + 0 + + + + + + + + + 2016 + 10 + 1 + 10 + 4 + 0 + + + + + + + 18 + Our data suggest the possibility of using macrolides as 'chemosensitizers' for EGFR-TKI therapy in pancreatic cancer patients to enhance non-apoptotic tumor cell death induction. + + + + 26718641 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 12 + 13 + 0 + + + + + + + 18 + Evaluation of GPER1, EGFR and CXCR1 mRNA/protein expression may be helpful in differential diagnosis of malignant follicular thyroid carcinoma and benign follicular thyroid adenoma. + + + + 26617848 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 12 + 12 + 0 + + + + + + + 18 + EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor endocytosis in HeLa cells + + + + 26993163 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 11 + 41 + 0 + + + + + + + 18 + Data suggest that the combination of peritumoral Cbl and EGFR serves as a much stronger indicator to make an accurate prognosis, especially during early recurrence. + + + + 26474280 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 10 + 18 + 0 + + + + + + + 18 + Study shows that high EGFR protein expression and exon 9 PIK3CA activating mutations are independent prognostic factors in triple negative breast cancers. + + + + 26680641 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 10 + 13 + 0 + + + + + + + 18 + single EGFR exon 18 mutations may be an indicator of poor prognosis of lung adenocarcinoma compared with complex EGFR exon 18 mutations or classic mutations + + + + 26354324 + + + + + + + + 2016 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 24 + 10 + 9 + 0 + + + + + + + 18 + NF-kappaB and EGFR expression was significantly elevated during the occurrence and development of esophageal carcinoma, and expression of these factors appears to be correlated with cancer progression. + + + + 26681028 + + + + + + + + 2016 + 9 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 17 + 12 + 9 + 0 + + + + + + + 18 + In lung adenocarcinomas, EGFR mutation was higher in female and non-smoking patients, KRAS mutation only in patients with wild-type EGFR gene was higher. + + + + 26582224 + + + + + + + + 2016 + 9 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 17 + 12 + 7 + 0 + + + + + + + 18 + Lung cancers harboring exon 18 mutations should not be overlooked in clinical practice. These cases can be best treated with afatinib or neratinib. + + + + 26206867 + + + + + + + + 2016 + 9 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 17 + 12 + 7 + 0 + + + + + + + 18 + Data identified several cases of complex EGFR mutations, and concomitant EGFR mutations and ALK rearrangements in non-small cell lung cancer + + + + 26505450 + + + + + + + + 2016 + 9 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 17 + 12 + 6 + 0 + + + + + + + 18 + High EGFR expression is associated with poor Response to Sunitinib in Breast Cancer. + + + + 25971960 + + + + + + + + 2016 + 9 + 17 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 17 + 12 + 1 + 0 + + + + + + + 18 + This study describes a pro-metastatic EGFR/Src-dependent beta4 integrin/FAK complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer. + + + + 26549523 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 12 + 6 + 0 + + + + + + + 18 + beta3-alphaC deletions are activating mutations in EGFR. These deletions are resistant to the alphaC 'Out' inhibitor lapatinib. + + + + 26996308 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 12 + 0 + 0 + + + + + + + 18 + a variety of EGFR structures have identically good performance in the scoring and ranking of known inhibitors, indicating that the choice of the receptor structure has little effect on the screening. + + + + 26476847 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 11 + 33 + 0 + + + + + + + 18 + both EGFR and EMMPRIN proteins are potential targets for cancer therapy and EMMPRIN can be used as a prognostic marker of a more aggressive biological behavior in patients with head and neck squamous cell carcinoma + + + + 26296920 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 11 + 25 + 0 + + + + + + + 18 + These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF signaling. + + + + 26489763 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 10 + 44 + 0 + + + + + + + 18 + EGFR L858R mutation and 2nd-line chemotherapy caused a poor outcome. + + + + 26609535 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 10 + 15 + 0 + + + + + + + 18 + we identify that EGFR mutations might associate with more aggressive tumor progression than the wild types in non-small-cell lung cancer + + + + 26589606 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 10 + 9 + 0 + + + + + + + 18 + Mitochondrial translocation of EGFR may enhance cancer invasion and metastasis through regulating mitochondria dynamics in non-small cell lung carcinoma. + + + + 26497368 + + + + + + + + 2016 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 10 + 10 + 6 + 0 + + + + + + + 18 + Our study suggests that telomerase (TERT)and telomere function may be essential for carcinogenesis of EGFRmut(+) non-small cell lung cancer + + + + 26149460 + + + + + + + + 2016 + 9 + 3 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 3 + 11 + 26 + 0 + + + + + + + 18 + Our findings indicate that EGFR inhibitors may reactivate oxidative phosphorylation of cancer cells and provide a mechanistic clue for the rational combination of agents targeting EGFR-dependent proliferation and glucose metabolism in cancer therapy + + + + 26216352 + + + + + + + + 2016 + 9 + 3 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 3 + 11 + 5 + 0 + + + + + + + 18 + HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study + + + + 27069134 + + + + + + + + 2016 + 9 + 3 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 3 + 11 + 5 + 0 + + + + + + + 18 + concluded that EGFR can be activated intracellularly by FASN-dependent palmitoylation + + + + 26378037 + + + + + + + + 2016 + 9 + 3 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 3 + 10 + 46 + 0 + + + + + + + 18 + Data demonstrated the significance of PR extranuclear signaling through PPD interactions in EGFR-mediated proliferation and signaling in NSCLC. + + + + 26892043 + + + + + + + + 2016 + 9 + 3 + 10 + 2 + 0 + + + + + + + + + 2016 + 9 + 3 + 10 + 39 + 0 + + + + + + + 18 + ATM inhibition may facilitate the gefitinib-dependent repression of the phosphorylation of EGFR and/or its downstream factors, to exert anticancer effects against non-small-cell lung cancer cells with the sensitive EGFR mutation + + + + 26825989 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 12 + 50 + 0 + + + + + + + 18 + Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer. + + + + 26439803 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 12 + 50 + 0 + + + + + + + 18 + Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1, 2 and 3 in Periampullary Adenocarcinoma + + + + 27070783 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 12 + 30 + 0 + + + + + + + 18 + The pemetrexed-carboplatin combination was effective and well-tolerated in patients with EGFR-wild-type non-squamous NSCLC. + + + + 27069157 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 12 + 30 + 0 + + + + + + + 18 + Two key biological processes for progressive hearing loss, TrkA signaling pathway and EGF receptor signaling pathway were significantly and differentially enriched by the two sets of allele-specific target genes of miR-96. + + + + 26564979 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 55 + 0 + + + + + + + 18 + EGFRvIII expression does not alter radiosensitivity with or without anti-EGFR treatment + + + + 26418954 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 55 + 0 + + + + + + + 18 + EGFR expression and activation was not found to be an independent prognostic factor in breast cancer survival outcome. + + + + 27055285 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 44 + 0 + + + + + + + 18 + an "oncogene swap" from EGFR to MET is a novel resistant mechanism to the EGFR-TKI. This novel mechanism should be considered in order to avoid futile inhibition of the original oncogene. + + + + 26845230 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 34 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in Non-Small-Cell Lung Carcinoma. + + + + 26375053 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 14 + 0 + + + + + + + 18 + Our data confirmed that exon-20 insertions confer poor response to all known EGFR inhibitors, and suggested that these models can be utilized to facilitate the discovery of new therapies targeting NSCLC harboring exon-20 insertions + + + + 26891175 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 11 + 1 + 0 + + + + + + + 18 + results suggested that C/EBPalpha-saRNA successfully inhibited HCC metastasis by inhibiting EGFR/beta-catenin signaling pathway mediated EMT in vitro and in vivo + + + + 27050434 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 10 + 54 + 0 + + + + + + + 18 + our data suggest roles for HRAS and EGFR as drivers in a subset of poroma and porocarcinoma. + + + + 27067779 + + + + + + + + 2016 + 8 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 27 + 10 + 8 + 0 + + + + + + + 18 + ubiquitylation and interaction with AP-2, contribute to EGFR endocytosis via clathrin-coated pits in a stochastic fashion + + + + 26251007 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 12 + 24 + 0 + + + + + + + 18 + estimated prevalence of sensitizing EGFR mutations (exon 19 del, exon 21 L858R) in an unselected samples of newly diagnosed advanced non-small cell lung cancer patients in Spain + + + + 25766256 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 12 + 17 + 0 + + + + + + + 18 + we report for the first time the amplification of the coding exon 8 of EGFR in invasive breast cancer + + + + 22882128 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 12 + 16 + 0 + + + + + + + 18 + Opioid receptor delta-mediated activation of ERK1/2 is via ligand-specific transactivation of EGFR. + + + + 26211551 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 12 + 0 + 0 + + + + + + + 18 + rare mutation in a patient with lung adenocarcinoma successfully treated with gefitinib + + + + 26206728 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 11 + 57 + 0 + + + + + + + 18 + mutations are associated with survival outcomes in advanced lung cancer + + + + 26239567 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 11 + 41 + 0 + + + + + + + 18 + EGFR amplification and EGFRvIII expression were associated with an unfavourable prognosis for glioma patients + + + + 22978472 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 11 + 25 + 0 + + + + + + + 18 + measurements comprising the receptors EGFR, ERBB3 (HER3), and the cyclin-dependent kinase inhibitor p27 (CDKN1B) was found to accurately predict dependence on PI3K/AKT vs. MAPK/ERK signaling axes in HER2+ cancers + + + + 27035903 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 10 + 14 + 0 + + + + + + + 18 + Three out of the 110 SNPs were found to be associated with HCV outcome (P-values<0.03). rs11506105 in EGFR (epidermal growth factor receptor gene), and rs11881222 and rs12979860 in IL28B (interferon-lambda3 gene). + + + + 26378651 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 10 + 14 + 0 + + + + + + + 18 + mutational status is a prognostic factor for survival after recurrence in patients with resected lung adenocarcinoma + + + + 25986624 + + + + + + + + 2016 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2016 + 8 + 20 + 10 + 5 + 0 + + + + + + + 18 + Netrin-1 enhanced infectivity of hepatitis C virus particles and promoted viral entry by increasing the activation and decreasing the recycling of EGFR. + + + + 27031829 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 12 + 18 + 0 + + + + + + + 18 + Data show that Prolyl isomerase Pin1 is expressed in an epidermal growth factor receptor (EGFR)-mutant lung cancer tissue that has undergone partial epithelial-mesenchymal transition (EMT) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). + + + + 26752745 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 11 + 52 + 0 + + + + + + + 18 + A study evaluating the effect of small molecule T315 on EGFR degradation and therapeutic efficacy in vitro and in vivo using a mouse xenograft model found T315 effective at suppressing cancer cell proliferation, verified by combining T315 with afatnib. + + + + 26583948 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 55 + 0 + + + + + + + 18 + These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha in the EGFR endocytosis pathway. + + + + 26680696 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 51 + 0 + + + + + + + 18 + Distinct patterns of receptor-adaptor complex formation, site-specific phosphatase activity, and tight integration of positive and negative feedback occur in the early periods of EGFR signaling. + + + + 26929352 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 49 + 0 + + + + + + + 18 + The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer + + + + 26400330 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 45 + 0 + + + + + + + 18 + our data demonstrated that blockade of the EGFR might efficiently increase the antitumor activity of selumetinib in a subgroup of TNBC and that this phenomenon might be related to the effects of such combination on both ERK1/2 and AKT activation. + + + + 25959272 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 35 + 0 + + + + + + + 18 + EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified. + + + + 26441207 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 5 + 0 + + + + + + + 18 + results indicate that a divergence in AP-1 regulation determines cellular changes of breast cancer cells stimulated by ErbB receptors + + + + 26179713 + + + + + + + + 2016 + 8 + 13 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 13 + 10 + 5 + 0 + + + + + + + 18 + Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. + + + + 26858456 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 59 + 0 + + + + + + + 18 + Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway. + + + + 26491668 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 54 + 0 + + + + + + + 18 + Consecutive patients with advanced/recurrent non-small cell lung cancer (NSCLC)harboring activating EGFR mutations were treated with platinum combined with Pemetrexed + + + + 27306810 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 22 + 0 + + + + + + + 18 + The association may be most relevant in EGFR mutation-positive patients. + + + + 26386832 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 12 + 0 + + + + + + + 18 + The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer. + + + + 26448936 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 10 + 0 + + + + + + + 18 + Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility. + + + + 26377974 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 11 + 9 + 0 + + + + + + + 18 + Suggest that EGFR gene copy number gain-positive tumors represent an HPV-negative, aggressive subgroup of oropharyngeal squamous cell carcinoma. + + + + 26997438 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 44 + 0 + + + + + + + 18 + This study demonstrates that high serum COX-2 levels may indicate EGFR mutations in non-small cell lung cancer. + + + + 26464643 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 40 + 0 + + + + + + + 18 + Digital PCR analysis of plasma is feasible and accurate for detection of T790M mutation in NSCLC that becomes resistant to treatment with EGFR-TKIs. + + + + 26334838 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 40 + 0 + + + + + + + 18 + the discovery of EGFR mutations and ALK rearrangements has enabled the identification of patients who are more likely to benefit from a specific drug. + + + + 26537995 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 36 + 0 + + + + + + + 18 + In NSCLC patients who progressed after first-line EGFR TKIs. + + + + 26371700 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 31 + 0 + + + + + + + 18 + A positive correlation between EGFR mutational/amplification status and invasive capacity. + + + + 26342549 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 15 + 0 + + + + + + + 18 + The loss of expression of EGFR and retinoblastoma (Rb) in the LCNEC. + + + + 26384434 + + + + + + + + 2016 + 8 + 6 + 10 + 2 + 0 + + + + + + + + + 2016 + 8 + 6 + 10 + 7 + 0 + + + + + + + 18 + These results suggest that targeting the production of CXCR4 and blocking the CXCL12-CXCR4 pathway might be effective strategies for treating NSCLCs harboring a specific type of EGFR mutation. + + + + 26338423 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 54 + 0 + + + + + + + 18 + Lung adenocarcinomas with L858R mutation, rather than exon 19 deletion or wild-type EGFR gene, prefer to locate over the upper lungs + + + + 26645716 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 48 + 0 + + + + + + + 18 + showed that one of these intermediates, fructose 1,6 bisphosphate (F1,6BP), directly binds to and enhances the activity of the EGFR + + + + 26759242 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 47 + 0 + + + + + + + 18 + Data show that grape seed proanthocyanidins could inhibit cell proliferation, invasion and migration of A549 cells, which might be related to the down-regulation of epidermal growth factor receptor and N-cadherin and the up-regulation of E-cadherin. + + + + 26927375 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 45 + 0 + + + + + + + 18 + Higher mutation fraction was associated with greater EGFR TKI response rate (odds ratio 1.58, 95% CI = 1.21-2.07, P = 0.0008), longer TTF (hazard ratio 0.80, 95% CI = 0.68-0.92, P = 0.003) and better OS (hazard ratio 0.81, 95% CI = 0.67-0.99, P = 0.04). + + + + 26889973 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 43 + 0 + + + + + + + 18 + while transcript and protein levels of EGFR and ErbB2 were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 and ErbB4 expression. + + + + 26886748 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 43 + 0 + + + + + + + 18 + In summary, our results showed that negative HCRP-1 expression is an independent prognostic factor for RCC patients. + + + + 26304749 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 41 + 0 + + + + + + + 18 + prevalence of EGFR mutation (11.9%) detected in our Lebanese population is similar to that observed in the Caucasian population + + + + 26362141 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 41 + 0 + + + + + + + 18 + Detection of T790M with plasma DNA was correlated with EGFR mutation type, exon 19 deletions and tumor progression + + + + 26577492 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 27 + 0 + + + + + + + 18 + Data suggest that Src kinases inhibitors may act with different mechanisms in non-small cell lung cancer (NSCLC) depending on EGF receptor (EGFR)/Ras protein (Ras) mutational profile. + + + + 26325669 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 18 + 0 + + + + + + + 18 + non-small-cell lung cancer (NSCLC) patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) could benefit from the same TKI therapy through months to years of disease control. + + + + 26172562 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 16 + 0 + + + + + + + 18 + It blocked activation of EGFR, HER2 and downstream Akt and Erk. + + + + 26437915 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 10 + 0 + + + + + + + 18 + EGFR expression was studied by immunohistochemistry and EGFR mutations (exons 18-24) by PCR cloning and sequencing. + + + + 26436086 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 10 + 0 + + + + + + + 18 + Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. + + + + 26360782 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 11 + 5 + 0 + + + + + + + 18 + EGFR promoter methylation was common, and it might be associated with HPV 16 infection in Chinese cervical squamous cell carcinoma. + + + + 25789535 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 42 + 0 + + + + + + + 18 + EGFR protein overexpression was observed in one fourth of triple negative breast cancer cases with very low incidence of EGFR-activating mutations in patients of Western India. + + + + 25789532 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 42 + 0 + + + + + + + 18 + Review/Meta-analysis: BIM deletion polymorphism was associated with poor response in NSCLC patients who received EGFR-TKIs treatment. + + + + 26325082 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 30 + 0 + + + + + + + 18 + Data show that lenalidomide increased the antitumor effect of 3C10-CAR T cells on epidermal growth factor receptor variant III (EGFRvIII)-expressing glioma cells. + + + + 26450624 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 28 + 0 + + + + + + + 18 + Results indicate that monoclonal antibody-dendriplexes represent a great potential to be used as efficient targeted gene delivery carriers in EGFR-overexpressing tumor cells. + + + + 26309162 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 26 + 0 + + + + + + + 18 + overexpressed EGFR significantly correlated with JAK2 and PD-L1 expression in a large cohort of head and neck cancer specimens. + + + + 26676749 + + + + + + + + 2016 + 7 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 7 + 30 + 10 + 5 + 0 + + + + + + + 18 + Data show that 11/105 patients failed all molecular analysis: no mutations in oncogenes EGFR, KRAS and NRAS were detected, and no ALK gene rearrangements or MET gene amplifications were identified. + + + + 26581482 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 11 + 28 + 0 + + + + + + + 18 + The frequency of EGFR mutations in the cancers that expressed P-gp, LRP, or both P-gp and LRP was significantly higher than that in cancers that did not express P-gp or LRP. + + + + 26632382 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 47 + 0 + + + + + + + 18 + Studied prevalence of EGFR activating mutations in squamous cell carcinomas and adenosquamous carcinomas of the lung in patients of the Southern Bulgarian region. + + + + 27180345 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 41 + 0 + + + + + + + 18 + High EGFR expression was an independent risk factor for shorter overall survival (OS), whereas high HER3 expression was associated with a borderline significant trend towards a longer OS. + + + + 26844548 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 35 + 0 + + + + + + + 18 + EGFR T790M is associated with drug resistance in Non-Small-Cell Lung Carcinoma. + + + + 26269204 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 34 + 0 + + + + + + + 18 + Inactivation of the EGFR with a blocking antibody decreased the S. aureus-mediated IL-1alpha and IL-1beta induction in primary keratinocytes. + + + + 26808616 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 33 + 0 + + + + + + + 18 + In operated pancreatic adenocarcinoma, incidence of mutations was: EGFR = 7%. + + + + 26754455 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 20 + 0 + + + + + + + 18 + Higher cell free EGFR mRNA expression may play an important role in causing distant metastases and reducing overall survival of Non-Small Cell Lung Cancer patients in the Indian population. + + + + 26434857 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 17 + 0 + + + + + + + 18 + Highly sensitive dPCR thus detected T790M in all NSCLC patients harboring activating EGFR mutations whether or not they had received EGFR-TKI treatment. + + + + 26015401 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 14 + 0 + + + + + + + 18 + Molecular marker expressions of both EGFR and p53 were found significantly associated with overall response, survivals and quality of life in oral squamous cell carcinoma patients. + + + + 26177827 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 7 + 0 + + + + + + + 18 + Proton-pump positive parietal cells were mostly EGFR immunoreactive whereas very few pepsinogen I (PGI)-positive chief cells were EGFR positive. + + + + 26399281 + + + + + + + + 2016 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 16 + 10 + 7 + 0 + + + + + + + 18 + Overexpression of MMP2 and EGFR were independent risk factors for mortality in non-small cell lung cancer patients. + + + + 27273943 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 11 + 46 + 0 + + + + + + + 18 + Meta-analysis: no significant difference between KRAS G13D and other KRAS mutant colorectal tumours in terms of treatment benefit from anti-EGFR mAbs. + + + + 26812186 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 11 + 30 + 0 + + + + + + + 18 + Data indicate a positive Correlation between tumor Cell tntravasation and epidermal growth factor receptor (EGFR) expression. + + + + 26408256 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 49 + 0 + + + + + + + 18 + Data report rare EGFR mutations in patients with non-small cell lung cancer of unknown clinical significance. + + + + 26266520 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 47 + 0 + + + + + + + 18 + These results suggest that the iEA index or a combination of polymorphisms in EGFR and ANXA3 may serve as predictive factors of drug response, and therefore could be useful for optimal selection of chemotherapy regimens. + + + + 26475168 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 14 + 0 + + + + + + + 18 + Retreatment anti-EGFR agents were cetuximab (n = 76) or cetuximab plus erlotinib (n = 13). The median interval time between prior and retreatment regimens was 4.57 months (range: 0.46-58.7). + + + + 26474549 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 14 + 0 + + + + + + + 18 + Identification of a novel tumor-promoting function for IGFBP2 of activating EGFR/STAT3 signaling and facilitating EGFR accumulation in the nucleus, thereby deregulating EGFR signaling by two distinct mechanisms. + + + + 25893308 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 11 + 0 + + + + + + + 18 + Circulating DNA is easy to obtain, convenient biological material, although quantitative analysis cannot be used as diagnostic tool, but it can be applied to determination of EGFR mutations, basis of the tyrosine kinase inhibitors application. + + + + 25769456 + + + + + + + + 2016 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 7 + 2 + 10 + 6 + 0 + + + + + + + 18 + High expression of COX-2, EGFR, and VEGF is an unfavorable prognostic factor in ESCC, and could be used as a poor prognosis indicator for the ESCC patients. + + + + 26323923 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 32 + 0 + + + + + + + 18 + In summary, this study identified a novel role for EGFRvIII in hypoxia tolerance, supporting an important link between hypoxia and subcellular localization alterations of the receptor. + + + + 26742423 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 32 + 0 + + + + + + + 18 + EGF-induced sodium influx regulates EGFR trafficking through increased microtubule acetylation. + + + + 26382850 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 30 + 0 + + + + + + + 18 + there is HER2 and EGFR, but not VEGFR expression in micropapillary urothelial carcinoma with invasive urothelial carcinoma + + + + 25293577 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 27 + 0 + + + + + + + 18 + Both approaches were specific and sensitive for EGFR mutational analysis. + + + + 26249748 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 26 + 0 + + + + + + + 18 + This article reviews the research into methods of targeting acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) therapy, including third-generation EGFR TKIs that target the T790M resistance mutation and other agents in development. [review] + + + + 26351816 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 11 + 19 + 0 + + + + + + + 18 + activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is overexpressed in many types of human cancer. + + + + 26721396 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 56 + 0 + + + + + + + 18 + Cell blocks were underutilized for EGFR testing. + + + + 25376259 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 52 + 0 + + + + + + + 18 + COPD-related NSCLC patients exhibited low prevalences of EGFR mutations and ALK rearrangements compared with the non-COPD group. Further studies are required regarding the molecular mechanisms underlying lung cancer associated with COPD + + + + 26555338 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 52 + 0 + + + + + + + 18 + EGFR knockdown led to upregulation of NKX2-1, suggesting a negative feedback loop. combined knockdown of NKX2-1 and EGFR in NCI-H1819 lung cancer cells reduced cell proliferation more than knockdown of either alone. + + + + 26556242 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 52 + 0 + + + + + + + 18 + EGFR Mutation is associated with response to chemotherapy in Non-Small Cell Lung Cancer. + + + + 26536620 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 47 + 0 + + + + + + + 18 + Studies indicate that epidermal growth factor receptor (EGFR) pathway is frequently activated in pancreatic cancer and therefore it is a rational target for new treatments. + + + + 26355547 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 45 + 0 + + + + + + + 18 + Certain EGFR glycosylation signatures appear to be unique to colorectal cancer. + + + + 26085185 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 43 + 0 + + + + + + + 18 + data indicate that inhibition of Notch cleavage may not affect cell number in the presence of EGFR mutations and that EGFR may affect Notch signalling suggesting that a dual inhibition of these pathways might be promising in NSCLC + + + + 26497899 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 41 + 0 + + + + + + + 18 + The MZI-IDA sensor system is proved to be capable of fast and accurate detection of the L858R mutation of EGFR gene in clinical samples. This may greatly help the clinicians develop an appropriate treatment plan. + + + + 26233643 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 34 + 0 + + + + + + + 18 + we demonstrate a simple and efficient method to detect various exon 19 deletion mutations of EGFR using a single probe set comprising of an oligo-quencher (oligo-Q) and a molecular beacon (MB). + + + + 26233641 + + + + + + + + 2016 + 6 + 28 + 10 + 9 + 0 + + + + + + + + + 2016 + 6 + 28 + 10 + 34 + 0 + + + + + + + 18 + Helicobacter pylori induces internalization of EGFR via novel TAK1-p38-serine activation pathway which is independent of HB-EGF. + + + + 25704183 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 12 + 19 + 0 + + + + + + + 18 + Mutation of C797S in EGFR is a novel mechanism of acquired resistance to third-generation TKIs. The context in which the C797S develops with respect to the other EGFR alleles affects the efficacy of subsequent treatments. + + + + 25964297 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 12 + 2 + 0 + + + + + + + 18 + study describes a novel EGFR exon 12 mutation acquired in gastrointestinal tumors of 1 out of 3 patients treated with panitumumab; the EGFR G465R mutation introduces a positive charge within the overlap of the panitumumab and cetuximab epitopes; it abrogates antibody binding and mediates cross-resistance to both antibodies in EGFR G465R-transfected Ba/F3 cells + + + + 26059438 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 12 + 1 + 0 + + + + + + + 18 + EGFR expression and methylation levels were closely related to cancer cell pathological type and stage in NSCLC patients. + + + + 26345914 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 11 + 44 + 0 + + + + + + + 18 + KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy + + + + 26025929 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 11 + 41 + 0 + + + + + + + 18 + Twenty-five EGFR-activating mutations (G719S, G719A, G719C, S768I, L858R, and L861Q and 19 mutations of exon 19-Del) were analyzed;none of the EGFR-activating mutations studied was found being associated with triple-negative breast cancer in China + + + + 26290189 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 11 + 26 + 0 + + + + + + + 18 + Targeting ERBB1 signaling suppresses melanoma tumor growth. + + + + 26967479 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 56 + 0 + + + + + + + 18 + among lung adenocarcinoma patients with EGFR mutations, those mutated at exon 19 had the highest incidence of brain metastasis(BM); patients with EGFR mutations are more likely to develop heterochronous BM + + + + 26050023 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 46 + 0 + + + + + + + 18 + it is essential to confirm any EGFR L858R-positive cases by molecular methods or at least discard the presence of HER2 overexpression/amplification before rendering a diagnosis + + + + 25390349 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 41 + 0 + + + + + + + 18 + Epidermal Growth Factor Receptor P753S Mutation is associated with responsive to chemotherapy in cutaneous Squamous Cell Carcinoma. + + + + 24934779 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 19 + 0 + + + + + + + 18 + These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells + + + + 26683696 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 18 + 0 + + + + + + + 18 + Report using biosensing techniques to monitor dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation. + + + + 26692031 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 18 + 0 + + + + + + + 18 + Case Report: L747P (2239-2240 TT>CC) in exon 19 is a rare EGFR mutation that appears to lead to gefitinib resistance and might accelerate liver metastases. + + + + 26339441 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 15 + 0 + + + + + + + 18 + EGFR may be involved in early stage in development of pancreatic ductal adenocarcinoma. + + + + 26339400 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 15 + 0 + + + + + + + 18 + Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway. + + + + 26261554 + + + + + + + + 2016 + 6 + 11 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 11 + 10 + 10 + 0 + + + + + + + 18 + MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma. + + + + 25735773 + + + + + + + + 2016 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 4 + 11 + 37 + 0 + + + + + + + 18 + Data show that significantly better overall survival was observed in patients with coexistence of high epidermal growth factor receptor (EGFR) expression and low p-Akt proto-oncogene protein expression. + + + + 26124180 + + + + + + + + 2016 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 4 + 10 + 41 + 0 + + + + + + + 18 + Intratumor Heterogeneity of ALK-Rearrangements and Homogeneity of EGFR-Mutations in Mixed Lung Adenocarcinoma + + + + 26422230 + + + + + + + + 2016 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2016 + 6 + 4 + 10 + 30 + 0 + + + + + + + 18 + EGFR and KRAS mutation status are both predictive factors for the treatment efficacy. + + + + 26055897 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 12 + 20 + 0 + + + + + + + 18 + Gemcitabine plus erlotinib is more effective than gemcitabine alone for treating metastatic pancreatic cancer patients, especially those with EGFR mutations. + + + + 26046796 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 12 + 16 + 0 + + + + + + + 18 + Study shows the phosphorylation of EGFR and HER2 after MEK inhibition in a MEK1-mutated gastric cancer cell line suggesting that EGFR and HER2 activation may serve as a potential mechanism responsible for the resistance to a MEK inhibitor. + + + + 26081723 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 12 + 11 + 0 + + + + + + + 18 + The expression of CD146 and HIF1a was positively correlated with EGFR and CD31, respectively in salivary gland adenoid cystic carcinoma. + + + + 25997612 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 11 + 32 + 0 + + + + + + + 18 + EGF stimulates loss of FOXO3/SIRT6, which is blockaded by the inhibition of upstream pathways as well as lipid synthesis, revealing existence of a negative regulatory loop between LDs and FOXO3/SIRT6. + + + + 26657850 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 11 + 28 + 0 + + + + + + + 18 + Report bio-ferrography immunomagnetic isolation procedure for the separation of EGFR high positive circulating tumor cells. + + + + 25854597 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 11 + 4 + 0 + + + + + + + 18 + These findings suggest that activation of EGFR in ovarian cancer cells during platinum treatment contributes to the development of platinum resistance. + + + + 26351843 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 11 + 2 + 0 + + + + + + + 18 + EGFR and p53 are the major targets in TNBC also for our population. + + + + 26060045 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 10 + 58 + 0 + + + + + + + 18 + HDAC9 promotes tumor formation of glioblastoma via TAZ-mediated EGFR pathway activation. + + + + 25760078 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 10 + 54 + 0 + + + + + + + 18 + Report EGFR gene amplification in selected cohort of patients with pulmonary metastases of malignant melanoma and prognostic implications. + + + + 26305188 + + + + + + + + 2016 + 5 + 28 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 28 + 10 + 6 + 0 + + + + + + + 18 + the human EGFR is subjected to O-GlcNAcylation in the A431 and A549 tumor cell lines. + + + + 26108188 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 13 + 3 + 0 + + + + + + + 18 + The ultra-sensitive ddPCR assay revealed that pretreatment T790M was found in the majority of NSCLC patients with EGFR-activating mutations. + + + + 25882755 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 12 + 7 + 0 + + + + + + + 18 + Exon 19 deletion in EGFR gene is associated with response to therapy in non-small cell lung cancer patients. + + + + 26041721 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 11 + 48 + 0 + + + + + + + 18 + Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations. + + + + 25669832 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 11 + 48 + 0 + + + + + + + 18 + in H2170 cells and H1975 cells, simultaneous inhibition of key Wnt or mTOR pathway proteins in addition to EGFR and c-Met may be a promising strategy for overcoming EGFR and c-Met TKI resistance in NSCLC patients. + + + + 26301867 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 54 + 0 + + + + + + + 18 + EGF-induced expression of HIF-1alpha and its targets, vascular endothelial growth factor (VEGF) and BNIP. + + + + 24798801 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 32 + 0 + + + + + + + 18 + significant inhibition of the EGFR pathway (using EGFR as the readout) was observed in patients treated with panitumumab, but this was not observed in patients treated with erlotinib + + + + 25878330 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 26 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in non-small cell lung cancer patients. + + + + 25990507 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 20 + 0 + + + + + + + 18 + Although positive predictors of response to anti-EGFR antibodies remain unknown, multiple determinants of resistance have been described, including alterations interfering with antibody-receptor interaction, deregulation of parallel signaling pathways + + + + 26071484 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 11 + 0 + + + + + + + 18 + Results found that plasma soluble EGFR was significantly decreased in the non-small cell lung cancer (NSCLC) patients group as compared to the control group, and inhibits growth and migration of NSCLC cells in vitro. + + + + 26295387 + + + + + + + + 2016 + 5 + 21 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + Data indicate a potent and specific ADAM metallopeptidase domain 17 (ADAM17) inhibitory antibody, MEDI3622, which induces tumor regression or stasis in many epidermal growth factor receptor (EGFR)-dependent tumor models. + + + + 25948294 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 12 + 24 + 0 + + + + + + + 18 + Data show that dacomitinib efficiently impairs epidermal growth factor receptor (EGFR) signaling in vivo and has an effect on murine model tumor growth and survival in EGFR-amplified glioblastomas (GBM) cells. + + + + 25939761 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 12 + 19 + 0 + + + + + + + 18 + GSTP1 tyrosine phosphorylation by EGFR controls the interaction of GSTP1 with JNK and Apoptosis in Brain Tumor Cells. + + + + 26429914 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 12 + 18 + 0 + + + + + + + 18 + in the NMA cases, none of these factors was statistically significant. In a univariate analysis, neither EGFR nor E-cadherin expression showed a significant impact on disease-free or overall survival. + + + + 26262813 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 11 + 47 + 0 + + + + + + + 18 + Results indicate that AMG 595 is a promising candidate to evaluate in epidermal growth factor receptor variant III (EGFRvIII)-expressing glioblastoma multiforme (GBM) patients. + + + + 25931519 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 11 + 32 + 0 + + + + + + + 18 + Data show that MM-151, an oligoclonal antibody, targeted against nonoverlapping epitopes on epidermal growth factor receptor (EGFR). + + + + 25911688 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 11 + 8 + 0 + + + + + + + 18 + we have demonstrated for the first time that the EGFR-T790M-mutation occurs in primary human breast cancer patients. In the present study the EGFR-T790M mutation was not accompanied by any simultaneous EGFR-activating mutation + + + + 26267891 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 11 + 8 + 0 + + + + + + + 18 + we show that miR-205-5p directly regulates the expression of p63 which is in turn involved in the EGFR expression suggesting a miR-205/p63/EGFR regulation. + + + + 26181203 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 10 + 52 + 0 + + + + + + + 18 + we observed that EGFR expression was directly involved with poor prognosis of tamoxifen-treated breast cancer patients using the GSE1378 date set + + + + 26166014 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 10 + 45 + 0 + + + + + + + 18 + Patients with EGFR-mutated non-small-cell lung cancer were more likely to develop brain metastases, but apparently also survived longer after brain metastases + + + + 25336382 + + + + + + + + 2016 + 5 + 14 + 10 + 3 + 0 + + + + + + + + + 2016 + 5 + 14 + 10 + 42 + 0 + + + + + + + 18 + These results demonstrate coupling of CXCR7 with EGFR to regulate proliferation of breast cancer cells and suggest an important ligand-independent role of CXCR7 in breast cancer cells growth. + + + + 25168820 + + + + + + + + 2016 + 5 + 7 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 7 + 10 + 54 + 0 + + + + + + + 18 + EGFR, ErbB2 and MET genes are frequently amplified in gastric carcinoma. + + + + 25820598 + + + + + + + + 2016 + 5 + 7 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 7 + 10 + 23 + 0 + + + + + + + 18 + Crystal structures of human EGFR-Mig6 complexes show how Mig6 rearranges after phosphorylation by EGFR to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation. + + + + 26280531 + + + + + + + + 2016 + 5 + 7 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 7 + 10 + 11 + 0 + + + + + + + 18 + EGFR amplification occurs frequently in lung ADC patients harboring EGFR activating mutations, and could serve as an indicator for better response from EGFR-TKI treatment. + + + + 26141217 + + + + + + + + 2016 + 5 + 7 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 7 + 10 + 9 + 0 + + + + + + + 18 + The incidence of EGFR mutations in Chinese patients with Esophageal Squamous Cell Carcinoma was higher than that of previous reports. EGFR mutations were mainly located in exons 19 and 21. + + + + 21615826 + + + + + + + + 2016 + 5 + 7 + 10 + 2 + 0 + + + + + + + + + 2016 + 5 + 7 + 10 + 4 + 0 + + + + + + + 18 + P2Y2 receptor and EGFR cooperate to promote prostate cancer cell invasion via ERK1/2 pathway. + + + + 26182292 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 12 + 7 + 0 + + + + + + + 18 + No association of beclin 1 with EGFR mutation was found (P > 0.05) in non-small cell lung cancer. + + + + 24720835 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 57 + 0 + + + + + + + 18 + Molecular dynamic simulations show that the formation of the asymmetric dimer changes the dynamics of EGFR kinase domain by suppressing fluctuation of the protein and altering the direction of motion of the protein. + + + + 25805329 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 56 + 0 + + + + + + + 18 + A sharp or extremely sharp increase in EGF blood plasma level with pronounced EGFR expression in complex endometrial hyperplasia (without atypia) is likely to indicate poor prognosis that may lead to the transformation into atypical form. + + + + 24523335 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 45 + 0 + + + + + + + 18 + The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. + + + + 26177020 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 30 + 0 + + + + + + + 18 + We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II. + + + + 25959864 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 22 + 0 + + + + + + + 18 + This study showed that the ubiquitination of EGFR in the presence of Cbl and Grb2 on three active sites displays a threshold effect as a function of EGF concentration. + + + + 26264748 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 11 + 0 + + + + + + + 18 + EGFR and KRAS mutations were low in lung squamous cell carcinomas, and had no significant correlation with clinical features. + + + + 26483334 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 11 + 0 + 0 + + + + + + + 18 + In non-apoptotic cells, nuclear EGFR induced SOS1 expression by directly binding to the SOS1 promoter. + + + + 25980493 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 10 + 39 + 0 + + + + + + + 18 + EGFR mutations are indicators of malignant transition in the progression to lung adenocarcinoma. + + + + 26374070 + + + + + + + + 2016 + 4 + 30 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 30 + 10 + 39 + 0 + + + + + + + 18 + the EGFR and ErbB-3 heterodimerization, regarded as the origin of intracellular signaling pathways, was investigated. + + + + 25993617 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 57 + 0 + + + + + + + 18 + Data demonstrate that insulin treatment induces EGFR activation by stimulating the interaction of EGFR with insulin-like growth factor receptor 1 (IGF-1R) + + + + 25341922 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 55 + 0 + + + + + + + 18 + Data suggest that AMP-activated protein kinase (AMPK) regulates HER-2 proto-oncogene protein and epidermal growth factor receptor (EGFR) in HER2-amplified breast cancer cells and activation of AMPK might provide therapeutic benefit in such cancers. + + + + 26143491 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 54 + 0 + + + + + + + 18 + these data suggest that reduced miR-133 levels in GBM tissues promotes cell growth and decreases cell apoptosis, possibly through targeting mRNA of EGFR to suppress its translation. + + + + 26138587 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 53 + 0 + + + + + + + 18 + Serum COX-2 level could help predict the responses of EGFR-protein kinase inhibitors and the PFS in patients harboring EGFR mutations. + + + + 26191267 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 40 + 0 + + + + + + + 18 + integrin alpha6beta4 stimulates invasion by promoting autocrine EGFR signaling through transcriptional up-regulation of key EGFR family members and by facilitating HGF-stimulated EGFR ligand secretion + + + + 26381405 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 40 + 0 + + + + + + + 18 + The anti-tumor effects of quercetin 3-O-glucoside were mediated by selectively inhibiting the EGFR-mediated FAK, AKT, MEK1/2, and ERK1/2 signaling pathway + + + + 26109002 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 32 + 0 + + + + + + + 18 + Activation of the epidermal growth factor receptor (EGFR) pathway was observed in recurrent tumors. + + + + 26581390 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 11 + 19 + 0 + + + + + + + 18 + Nuclear EGFR occurs in ameloblastomas in association with Cyclin D1 expression + + + + 25991665 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 10 + 48 + 0 + + + + + + + 18 + Report documents that half of T790M-positive EGFR-mutant lung cancers treated with rociletinib are T790-wild-type upon progression, suggesting that T790-wild-type clones can emerge as the dominant source of resistance. + + + + 25934077 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 10 + 42 + 0 + + + + + + + 18 + The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree. + + + + 26099724 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 10 + 16 + 0 + + + + + + + 18 + Exon 19 deletion in EGFR is an independent prognostic factor in Brain metastasis from non-small-cell lung cancer . It should be integrated into the prognostic scoring classification system for NSCLC. + + + + 26091796 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 10 + 12 + 0 + + + + + + + 18 + no significant difference in level in peritoneal lavage fluid of patients with advanced pancreatic cancer compared to the control group + + + + 26766154 + + + + + + + + 2016 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 23 + 10 + 12 + 0 + + + + + + + 18 + EGFR DNA methylation levels significantly increased following NSCLC malignancy upgrading, and showed negative correlation with mRNA expression. + + + + 26505339 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 12 + 6 + 0 + + + + + + + 18 + increased expression of Flot-2 and EGFR in non-small cell lung cancer patients is inversely proportional to the disease prognosis. + + + + 26161893 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 12 + 6 + 0 + + + + + + + 18 + EGFRvIII induces the expression and secretion of pigment epithelium-derived factor (PEDF) via activation of signal transducer and activator of transcription 3 (STAT3), thereby promoting self-renewal and tumor progression of glioma stem cells. + + + + 25992628 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 11 + 48 + 0 + + + + + + + 18 + EGFR protein structure based on X-ray crystallography results. + + + + 25286840 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 11 + 29 + 0 + + + + + + + 18 + E-cadherin may play a significant role in the sensitivity regulation of EGFR molecular targeting treatment. E-cadherin may provide important clues for selecting proper EGFR-TKI molecular targeting treatment. + + + + 26125777 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 10 + 47 + 0 + + + + + + + 18 + Tyr1068-phosphorylated EGFR predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer. + + + + 26247735 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 10 + 36 + 0 + + + + + + + 18 + Authors develop methods to detect five common EGFR somatic mutations in tumor tissues from NSCLC patients. + + + + 25918867 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 10 + 14 + 0 + + + + + + + 18 + Through selective knockout or inhibition of the network components, we show that the interaction between epidermal growth factor receptor (EGFR) and S100A4 modulates the sensitivity of angiogenesis development to matrix metalloproteinases (MMPs) activity + + + + 26057862 + + + + + + + + 2016 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2016 + 4 + 16 + 10 + 12 + 0 + + + + + + + 18 + Since EGFR and ER both are substrates for PTPH1 in vitro and in intact cells, these results indicate that an inhibitory EGFR-ER protein complex can be switched off through a competitive enzyme-substrate binding. + + + + 26079946 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 51 + 0 + + + + + + + 18 + SHB-EGF acts similarly to other EGFR ligands and is capable to induce EGFR nuclear translocation. + + + + 26016774 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 48 + 0 + + + + + + + 18 + Proteins induced by PIK3CA mutations correlated with EGFR signaling and reduced relapse-free survival in basal-like breast cancer. + + + + 25953087 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 38 + 0 + + + + + + + 18 + Our results indicate that the transactivation of HER2 and EGFR by the pro-inflammatory cytokine/neuropeptide SP in BC cells is a c-Src and MMP-dependent process. + + + + 26114632 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 37 + 0 + + + + + + + 18 + Thus, this study demonstrated effective chemotherapeutic potential of SFE by inducing apoptisis as well as inhibiting migration and their preliminary mechanism for human gastric cancer management. + + + + 26612919 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 28 + 0 + + + + + + + 18 + EGFR activation by EGF stimulation, exon-19 deletions, and L858R mutation could induce PD-L1 expression in nsclc. + + + + 25658629 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 23 + 0 + + + + + + + 18 + preliminary data suggest that SNP-216 polymorphism of the EGFR gene could be useful in predicting colorectal tumor response and the appearance of severe skin rash might also be associated + + + + 25039761 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 22 + 0 + + + + + + + 18 + EGFR copy number gain is related to crucial clinicopathological features and early recurrence, indicating that EGFR copy number gain might be a poor prognosis factor for Taiwanese HCC. + + + + 25765471 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 6 + 0 + + + + + + + 18 + EGFR mutation is associated with response to treatment in nonsmall-cell lung cancer. + + + + 25922063 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 5 + 0 + + + + + + + 18 + The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2 Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner + + + + 26068861 + + + + + + + + 2016 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 9 + 10 + 3 + 0 + + + + + + + 18 + Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt and ERK1/2 phosphorylation via A1R-mediated transactivation of EGFR. + + + + 25661317 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 12 + 4 + 0 + + + + + + + 18 + EGFRL858R mutation in circulating DNA is a negative prognostic biomarker in non-small cell lung carcinoma patients. + + + + 26181014 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 35 + 0 + + + + + + + 18 + data suggest one-step screening platform for KIF5B-RET as well as EGFR, K-RAS, ALK oncogenic mutations be necessary for lung adenocarcinoma patients + + + + 26268359 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 35 + 0 + + + + + + + 18 + Study group precludes statistical significance. EGFR mutations seem to correlate with TTF1 status. + + + + 26793845 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 35 + 0 + + + + + + + 18 + We present a comprehensive analysis of mutational changes affecting key members of the EGFR signaling pathway emerging in tumor biopsies of patients treated with cetuximab and in cell models + + + + 25623215 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 29 + 0 + + + + + + + 18 + EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China. + + + + 24935562 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 23 + 0 + + + + + + + 18 + CHCHD2 and EGFR protein expression levels were positively correlated and upregulated relative to normal lung in non-small cell lung carcinoma tumor-derived xenografts. + + + + 25784717 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 11 + 20 + 0 + + + + + + + 18 + Results indicate that EGFR expression is enhanced in pancreatic cancer cells through CD9 downregulation promoting cell proliferation and migration. + + + + 25955689 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 10 + 49 + 0 + + + + + + + 18 + Letter/Case Report: tertiary acquired EGFR mutation resulting on protein kinase inhibitor resistance. + + + + 26181354 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 10 + 39 + 0 + + + + + + + 18 + EGFR mutation-derived NSCLC patient carrying BIM deletion polymorphism had a shorter progression-free survival. + + + + 26148607 + + + + + + + + 2016 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 4 + 2 + 10 + 18 + 0 + + + + + + + 18 + Results show that suppression of EGFR membrane recycling by SNX1 appears to be critical for the activation of EGFR /PI3K/AKT signaling pathway in human lung cancer cells. + + + + 25653196 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 12 + 6 + 0 + + + + + + + 18 + HER2 and EGFR)on the breast cancer xenografts in a mouse orthotopic model were successfully detected in a multiplexed way, illustrating the potential of FRES as a molecular diagnostic instrument + + + + 25820115 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 11 + 53 + 0 + + + + + + + 18 + DSC MRI perfusion may have a role in identifying patients with EGFR gene amplification and EGFRvIII gene mutation status, potential targets for individualized treatment protocols. + + + + 24474262 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 11 + 20 + 0 + + + + + + + 18 + soluble EGFR is a potential candidate for metastasis-associated biomarkers of Hepatocellular carcinoma. + + + + 26105696 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 11 + 15 + 0 + + + + + + + 18 + Our findings support the genetic heterogeneity of non-small cell lung cancer in Latin America, confirming that the frequency of EGFR mutations is intermediate between that observed in the Asian and Caucasian populations. + + + + 25634006 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 10 + 51 + 0 + + + + + + + 18 + Besides the already reported indirect EGFR activation through GM3, sialidase NEU3 could also play a role on EGFR activation through its desialylation. + + + + 25922362 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 10 + 43 + 0 + + + + + + + 18 + Finally, a crystal structure of EGFR in complex with a primed Shc1 peptide reveals the structural basis for EGFR substrate specificity. + + + + 26551075 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 10 + 35 + 0 + + + + + + + 18 + UVC/cisplatin-triggered EGFR activation depends on EGFR internalization and intracellular retention. EGFR signalling from this MVB subpopulation delays apoptosis and might contribute to chemoresistance + + + + 26066081 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 10 + 31 + 0 + + + + + + + 18 + The majority of rare EGFR mutations was associated with smoking, shorter overall survival, and decreased tyrosine kinase inhibitor response when compared with classic EGFR mutations. + + + + 25664625 + + + + + + + + 2016 + 3 + 26 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 26 + 10 + 22 + 0 + + + + + + + 18 + EGFR and the T790M mutation have roles in non-small-cell carcinoma with squamous histology [multiple case reports] + + + + 24752053 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 12 + 4 + 0 + + + + + + + 18 + This study aims to evaluate the incidence of liver metastasis in a single population and look for potential correlations between EGFR mutations, liver infiltration and clinical outcomes. + + + + 26248464 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 11 + 42 + 0 + + + + + + + 18 + High EGFR expression is associated with triple-negative breast cancer. + + + + 25883211 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 11 + 32 + 0 + + + + + + + 18 + these results indicate that in HCFs, activation of NF-kappaB by c-Src-mediated transactivation of EGFR/PI3K/Akt cascade is required for TNF-alpha-induced VCAM-1 expression. + + + + 26173590 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 11 + 18 + 0 + + + + + + + 18 + The synergism between HER2 and EGFR in determining radiosensitivity. + + + + 25589492 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 24 + 0 + + + + + + + 18 + Meta-analysis/Review: expression of HER-2 in colorectal carcinoma patients was statistically significantly increased. + + + + 26229411 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 19 + 0 + + + + + + + 18 + HER2 and EGFR gene copy number gains may play an important role in the progression of carcinoma ex pleomorphic adenoma, in particular ductal-type CXPAs. + + + + 26345124 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 19 + 0 + + + + + + + 18 + The relative stability of EGFR amplification indicates that molecular data obtained in the primary tumor can be used to predict the EGFR status of the recurrent tumor. + + + + 25691693 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 19 + 0 + + + + + + + 18 + PIK3CA mutation acquisition is related to patient age and EGFR expression. + + + + 26209091 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 14 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) is frequently overrepresented in TNBC. + + + + 26093903 + + + + + + + + 2016 + 3 + 19 + 10 + 2 + 0 + + + + + + + + + 2016 + 3 + 19 + 10 + 9 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small-cell lung cancer. + + + + 25376513 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 48 + 0 + + + + + + + 18 + EGFR gene mutations are associated with response to chemotherapy in non-small cell lung cancer. + + + + 25695221 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 41 + 0 + + + + + + + 18 + Upregulation of EGFR and c-Met is associated with epithelial mesenchymal transition in response to increased matrix rigidity in pulmonary adenocarcinoma. + + + + 26000960 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 41 + 0 + + + + + + + 18 + our data suggest that the anti-inflammatory actions of paricalcitol in tubular cells could depend on the inhibition of TGF-a/ADAM17/EGFR pathway in response to aldosterone, showing an important mechanism of VDRAs action. + + + + 26064952 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 39 + 0 + + + + + + + 18 + the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment + + + + 25996283 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 39 + 0 + + + + + + + 18 + EGFR gene mutation is associated with non small cell lung carcinoma. + + + + 25637496 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 26 + 0 + + + + + + + 18 + Suggest different miRNA expression between EGFR mutation group and wild type group inlung adenocarcinoma. + + + + 26170125 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 11 + 0 + + + + + + + 18 + Cetuximab increases a P-gp substrate intracellular accumulation in both P-gp expressing cell lines, independently of their EGFR expression. + + + + 25930120 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 4 + 0 + + + + + + + 18 + In transgenic mice programmed to express both mutant oncogenes in the lung epithelium, the resulting tumors express either the KRAS, or the EGFR oncogene. + + + + 26047463 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 11 + 2 + 0 + + + + + + + 18 + Suggest that EGFR/ERK1/2 signaling pathway but not cholinergic pathway involved in chlorpyrifos-induced colorectal adenocarcinoma cell growth. + + + + 26514924 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 10 + 24 + 0 + + + + + + + 18 + Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR/NF-small ka, CyrillicB/AP-1 signaling pathways in human endothelial cells. + + + + 26514923 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 10 + 24 + 0 + + + + + + + 18 + Validate a locked nucleic acid based wild-type blocking PCR for the detection of EGFR exon 18/19 mutations in non-small cell lung carcinoma. + + + + 26022577 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 10 + 18 + 0 + + + + + + + 18 + Selective HSP90 blockade by ganetespib represents a potentially important complementary strategy to targeted TKI inhibition alone for inducing substantial antitumor responses and overcoming resistance, in both the mutant and WT-EGFR settings. + + + + 25077897 + + + + + + + + 2016 + 3 + 12 + 10 + 1 + 0 + + + + + + + + + 2016 + 3 + 12 + 10 + 17 + 0 + + + + + + + 18 + SPINK1 plays a role as a growth factor, signaling through the EGFR pathway in pancreatic ductal adenocarcinoma and neoplasms, and that the EGFR is involved in the malignant transformation of IPMN. + + + + 23475261 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 57 + 0 + + + + + + + 18 + Activation of TLR2 in airway remodeling results in induction of the expression of TGF-alpha, EREG, and AREG mRNA among the EGFR ligand family, and also activates EGFR signaling. + + + + 25180535 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 52 + 0 + + + + + + + 18 + we demonstrate that SEPT9 negatively regulates EGFR degradation by preventing the association of the ubiquitin ligase Cbl with CIN85, resulting in reduced EGFR ubiquitylation + + + + 25472714 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 26 + 0 + + + + + + + 18 + The therapeutic activity of TUSC2 could extend the use of erlotinib to lung cancer patients with wildtype EGFR. + + + + 26053020 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 23 + 0 + + + + + + + 18 + P53, EGFR and MGMT could play a role in the occurrence, development and deterioration of glioma. + + + + 26753647 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 12 + 0 + + + + + + + 18 + increased methylation level at EGFR promoter was found in tumour tissues than the corresponding adjacent noncancerous. + + + + 25959250 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 9 + 0 + + + + + + + 18 + High EGFR expression is associated with oral cavity neoplasms. + + + + 25547827 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 6 + 0 + + + + + + + 18 + These results showed that deguelin possessed antitumor effect by targeting Akt in dual axis such as EGFR and IGF1R signaling pathways and suggested that it provides an applicable therapeutic strategy for HNSCC patients. + + + + 26075254 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 11 + 3 + 0 + + + + + + + 18 + Data suggest that tyrosine-phosphorylated CaM (calmodulin) elicits strong up-regulation in ligand-dependent activity of EGFR (epidermal growth factor receptor) in vitro; for these studies CaM was phosphorylated by c-Src (cellular sarcoma kinase). + + + + 26399481 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 53 + 0 + + + + + + + 18 + ANO1 and EGFR form a functional complex that jointly regulates head & neck squamous cell carcinoma cell proliferation. + + + + 25823819 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 43 + 0 + + + + + + + 18 + We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR-containing endosomes. + + + + 25413345 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 35 + 0 + + + + + + + 18 + Overexpression of miR-200a in non-small lung cancer cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion. + + + + 26184032 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 34 + 0 + + + + + + + 18 + Results show that inhibition of the Shp2 PTP activity impairs mutant EGFR signaling and suppresses EGFRL858R-driven lung adenocarcinoma. + + + + 25730908 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 31 + 0 + + + + + + + 18 + Study demonstrates that down-regulation of GALNT1 is sufficient to suppress malignant phenotype of HCC cells by decreasing EGFR signaling. + + + + 25730904 + + + + + + + + 2016 + 3 + 5 + 10 + 4 + 0 + + + + + + + + + 2016 + 3 + 5 + 10 + 31 + 0 + + + + + + + 18 + In patients with EGFR mutations, women have better PFS to EGFR-TKIs than men, and rare EGFR mutations are more frequent in high grade adenocarcinomas than in low grade tumors. + + + + 25558790 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 11 + 55 + 0 + + + + + + + 18 + We review methods currently available and show the latest results from a new single-molecule localization-based method, fluorophore localization imaging with photobleaching (FLImP), using the epidermal growth factor (EGF) receptor (EGFR) + + + + 26009168 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 11 + 42 + 0 + + + + + + + 18 + The results of this study provide detailed structural insights and emphasize the important binding features of these compounds, which may assists in the design and development of novel EGFR inhibitors. + + + + 25069678 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 11 + 12 + 0 + + + + + + + 18 + In pretreated elderly patients with advanced or recurrent EGFR-wild type non-small cell lung cancer, daily oral erlotinib was well tolerated. + + + + 26043909 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 10 + 59 + 0 + + + + + + + 18 + Dual blockade of EGFR and HER3 may enhance the targeted disruption of HER family signaling in these cancers both by blocking parallel and overlapping signaling pathways and potentially blocking the emergence of resistance. + + + + 26034219 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 10 + 55 + 0 + + + + + + + 18 + Our data provide evidence that YAP1 upregulation of EGFR plays an important role in conferring therapy resistance in esophageal cancer cells. Targeting YAP1-EGFR axis may be more efficacious than targeting EGFR alone in esophageal cancer. + + + + 25739674 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 10 + 25 + 0 + + + + + + + 18 + study emphasized that the AXL and EGFR receptor tyrosine kinases were coexpressed in a subgroup of treatment-naive lung adenocarcinomas with or without EGFR mutations + + + + 26475093 + + + + + + + + 2016 + 2 + 27 + 10 + 2 + 0 + + + + + + + + + 2016 + 2 + 27 + 10 + 12 + 0 + + + + + + + 18 + p53 and EGFR expression was positively correlated in triple-negative breast cancer (TNBC), which enables us to explore the molecular biological characteristics of TNBC, so as to provide new ideas for the treatment of TNBC. + + + + 25966200 + + + + + + + + 2016 + 2 + 20 + 10 + 3 + 0 + + + + + + + + + 2016 + 2 + 20 + 11 + 44 + 0 + + + + + + + 18 + This is the first structure-based docking study for the selected protein targets and anticancer drug, and S100A8 and EGFR are attractive anticancer targets and midostaurin with effective drug properties for therapeutic intervention in kidney cancer + + + + 25789858 + + + + + + + + 2016 + 2 + 20 + 10 + 3 + 0 + + + + + + + + + 2016 + 2 + 20 + 11 + 29 + 0 + + + + + + + 18 + HER2 and PTEN expression appears as early as the 9-12 weeks period in the digestive tract, but HER2 expression decreases in the 21-24 weeks period and then disappears. EGFR appears only during the 13-16 weeks period and p53 is strong until week 21. + + + + 26193216 + + + + + + + + 2016 + 2 + 20 + 10 + 3 + 0 + + + + + + + + + 2016 + 2 + 20 + 11 + 23 + 0 + + + + + + + 18 + Age and N stage might be considered in predicting EGFR mutation type in NSCLC. + + + + 26554801 + + + + + + + + 2016 + 2 + 20 + 10 + 3 + 0 + + + + + + + + + 2016 + 2 + 20 + 11 + 23 + 0 + + + + + + + 18 + demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4 + + + + 26350464 + + + + + + + + 2016 + 2 + 20 + 10 + 3 + 0 + + + + + + + + + 2016 + 2 + 20 + 11 + 5 + 0 + + + + + + + 18 + Combinations of exonic deletions of exon 25 to 28 lead to the oncogenic activation of EGF receptor in the absence of ligand and consequent cellular transformation, indicating a significant role of C-terminal domain in modulating EGFR activation. + + + + 25826094 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 11 + 54 + 0 + + + + + + + 18 + EGFR mutations are associated with response to chemotherapy in colorectal cancer. + + + + 25628445 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 11 + 53 + 0 + + + + + + + 18 + The -216TT and -191AA genotypes and GA haplotype of the EGFR gene were found to be associated with an increased risk of gastric cancer in a Mexican population. + + + + 25867325 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 11 + 45 + 0 + + + + + + + 18 + RB is lost in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. + + + + 25758528 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 10 + 53 + 0 + + + + + + + 18 + The frequency of EGFR mutations is 63% in the southern Taiwanese lung adenocarcinoma patients. + + + + 25961746 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 10 + 52 + 0 + + + + + + + 18 + IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions. This may be relevant to other virus entry processes employing EGFR. + + + + 25757571 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 10 + 33 + 0 + + + + + + + 18 + Study confirmed that EGFR 3'UTR 774 T>C polymorphism interfered with miRNA/mRNA interaction, and showed that the minor allele was associated with an elevated risk for development of pulmonary hypertension in chronic obstructive pulmonary disease. + + + + 25925667 + + + + + + + + 2016 + 2 + 13 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 13 + 10 + 13 + 0 + + + + + + + 18 + Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR signaling pathway. + + + + 25673058 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 12 + 28 + 0 + + + + + + + 18 + This polyphenol is able to inhibit directly but partially the enzymatic activity of the EGFR intracellular domain. The present work shows that curcumin also influences the cell membrane environment of EGFR + + + + 25893361 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 12 + 27 + 0 + + + + + + + 18 + There were statistically significant correlations between the expression of PDGFR-alpha, c-Met, and EGFR and disease-free survival + + + + 25323095 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 11 + 49 + 0 + + + + + + + 18 + The anti-EGFR/irinotecan-based regimens were associated with the highest pR. + + + + 26461062 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 11 + 49 + 0 + + + + + + + 18 + Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition. + + + + 25146389 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 11 + 11 + 0 + + + + + + + 18 + Mutant EGFR enhances the oncogenic properties of MCF10A cell line, and increases sensitivity to gefitinib. + + + + 25969993 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 11 + 4 + 0 + + + + + + + 18 + EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR. + + + + 25969544 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 11 + 4 + 0 + + + + + + + 18 + All specimens appeared to be suitable for EGFR gene mutation analysis, irrespective nature or origin + + + + 25534657 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 10 + 47 + 0 + + + + + + + 18 + these data indicate that R198/R200 methylation of the EGFR plays an important role in regulating EGFR functionality and resistance to cetuximab treatment. + + + + 26571401 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 10 + 32 + 0 + + + + + + + 18 + Results show gene amplification of IGF1R and EGFR exclusively in malignant cases of phyllodes tumors suggesting a potential use as therapeutic targets. + + + + 25593300 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 10 + 24 + 0 + + + + + + + 18 + PCI of rGel/EGF was shown to be highly effective against EGFR-expressing cell lines. + + + + 25684137 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 10 + 9 + 0 + + + + + + + 18 + study concludes that while serum EGFR levels were elevated in breast cancer patients, EGFR level has no predictive and prognostic value in these patients + + + + 25259789 + + + + + + + + 2016 + 2 + 6 + 10 + 1 + 0 + + + + + + + + + 2016 + 2 + 6 + 10 + 5 + 0 + + + + + + + 18 + Inhibiting IL6 signaling in ovarian cancer cells and ovarian cancer xenografts upregulated EGFR signaling and ERK activation. + + + + 25670170 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 11 + 57 + 0 + + + + + + + 18 + EGFR mutations remodel the activated enhancer landscape of glioblastoma multiforme, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regulatory network in vitro and in vivo. + + + + 26455392 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 11 + 44 + 0 + + + + + + + 18 + The smoking status as a predictor of the efficacy of gefitinib in patients with NSCLC harboring activating EGFR mutations. + + + + 26335629 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 11 + 31 + 0 + + + + + + + 18 + Results suggest that the EGFR and NRas signaling axis are a central component of fibroinflammatory signaling. + + + + 25915403 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 11 + 29 + 0 + + + + + + + 18 + The study presents the results of an investigation of the spatial structure and mobility of the EGFR transmembrane domain and juxtamembrane regions in various membrane-like environments. + + + + 26440883 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 11 + 9 + 0 + + + + + + + 18 + EGFR IHC overexpression evaluated by scoring system 1 might be suitable to be used in predicting patients survival in ESCC. EGFR gene amplification showed delayed prognostic information after 20 months. + + + + 25953424 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 10 + 31 + 0 + + + + + + + 18 + MET gene may be useful in predicting shortened PFS and OS after Gefitinib treatment in lung adenocarcinoma. The correlation between MET gene status and clinical outcomes for EGFR-TKI should be further evaluated using large scale samples. + + + + 25886066 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 10 + 31 + 0 + + + + + + + 18 + 21 novel somatic variants in exons 18-21 of EGFR in adult Argentinean patients affected with non-small cell lung cancer were reported + + + + 26420346 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 10 + 29 + 0 + + + + + + + 18 + Data show that macrophage migration inhibitory factor (MIF) binds to the extracellular domain of epidermal growth factor receptor (EGFR). + + + + 26280537 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 10 + 5 + 0 + + + + + + + 18 + EGFR and TGF-alpha can be used as predictive markers for activity, fibrosis, and carcinogenesis in chronic hepatitis C patients. + + + + 26279457 + + + + + + + + 2016 + 1 + 30 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 30 + 10 + 5 + 0 + + + + + + + 18 + EGFR mutation was associated with lung cancer in never-smoker Asian females. + + + + 25760072 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 54 + 0 + + + + + + + 18 + CA-SSR1 Polymorphism in Intron 1 of the EGFR Gene in Patients with Malignant Tumors Who Develop Acneiform Rash Associated with the Use of Cetuximab + + + + 25721848 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 54 + 0 + + + + + + + 18 + The aim of the study was to evaluate the prognostic ability of the transcriptional profiling of the HER family genes in early breast cancer. + + + + 26021752 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 33 + 0 + + + + + + + 18 + Report inhibition of non-small cell lung cancer growth by a novel small molecular inhibitor of EGFR. + + + + 25730907 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 30 + 0 + + + + + + + 18 + High EGFR expression is associated with pancreatic cancer. + + + + 25686822 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 27 + 0 + + + + + + + 18 + EGFR mutations are associated with lung cancer. + + + + 26235264 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 16 + 0 + + + + + + + 18 + EPAS1 is a key factor in the EGFR-MET crosstalk. + + + + 25831463 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 11 + 13 + 0 + + + + + + + 18 + UNC50 may plays some roles in HCC progression by affecting the EGFR pathway + + + + 25738771 + + + + + + + + 2016 + 1 + 23 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 23 + 10 + 30 + 0 + + + + + + + 18 + Results demonstrate that acquired resistance of colorectal tumour cells to treatment with anti-EGFR mAb ICR62 is accompanied by an increased level of cell surface EGFR, and upregulation of phosphorylated HER-2 and HER-3 proteins. + + + + 26372697 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 23 + 0 + + + + + + + 18 + These results suggested that the mechanism underlying CD9-induced suppression of cell proliferation may involve the inhibition of phosphorylation of EGFR and the activity of PI3K/Akt and MAPK/Erk signaling pathways + + + + 25760022 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 13 + 0 + + + + + + + 18 + Coexpression of EGFR and CXCR4 predicts poor prognosis in resected pancreatic ductal adenocarcinoma + + + + 25679210 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 13 + 0 + + + + + + + 18 + results indicate that 31 pleural mesothelioma patients show a wild-type EGFR gene when analyzing the codons D19, 768, 790, 858+861, 731+734, 785, 797+801, 831, and 868, whereas 2 patients have a mutation in the EGFR gene in codon 719 + + + + 25679064 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 13 + 0 + + + + + + + 18 + These results suggested that ECHS1 may promote cell proliferation in hepatocellular carcinoma in an EGFR-dependent manner. + + + + 25760819 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 13 + 0 + + + + + + + 18 + KIAA1199 is an oncogenic protein induced by HPV infection and constitutive NF-kappaB activity that transmits pro-survival and invasive signals through EGFR signalling. + + + + 25366117 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 12 + 11 + 0 + + + + + + + 18 + MET transactivation in U87MG human glioma cells in vitro is proportional to EGFRvIII activity and involves MET heterodimerization associated with a focal adhesion kinase (FAK) scaffold. + + + + 25659577 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 11 + 57 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with gastric adenocarcinoma. + + + + 24626858 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 11 + 26 + 0 + + + + + + + 18 + High EGFR gene expression levels were associated with lymph node metastases in advanced gastric cancer. + + + + 24651981 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 11 + 10 + 0 + + + + + + + 18 + oncogenic EGFR kinase inhibition triggers release of exosome-like extracellular vesicles and impacts phosphoprotein and DNA content + + + + 26272609 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 55 + 0 + + + + + + + 18 + These findings unveil NF-kappaB activation as a critical adaptive survival mechanism engaged by EGFR oncogene inhibition and provide rationale for EGFR and NF-kappaB co-inhibition to eliminate residual disease and enhance patient responses. + + + + 25843712 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 47 + 0 + + + + + + + 18 + EGFR-mediated activation of the downstream effectors ERK1/2 in pSS SGEC appeared to require ADAM17-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR. + + + + 24664458 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 47 + 0 + + + + + + + 18 + Results showed that EGFR mutation was detected in 17.2% of Chinese patients with pure squamous-cell lung cancer, especially in females indicating the importance of this mutation in tailoring a personalized therapy with tyrosine kinase inhibitors. + + + + 25886585 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 41 + 0 + + + + + + + 18 + PGE2 enhances glioma cell survival and proliferation though its ability to trans-activate Epithelial Growth Factor receptor and beta-catenin + + + + 25749386 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 9 + 0 + + + + + + + 18 + this study verified that both Notch-1 and EGFR involved in glioblastoma multiforme (GBM) tumorigenesis and may provide important information for GBM clinical treatment and prognosis + + + + 25704190 + + + + + + + + 2016 + 1 + 16 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 16 + 10 + 7 + 0 + + + + + + + 18 + EGFR/ERBB4 expression in trophoblasts correlates with cell cycle progression and hyperplasia in complete hydatidiform moles + + + + 25740878 + + + + + + + + 2016 + 1 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 2 + 12 + 3 + 0 + + + + + + + 18 + Positive mEGFR overexpression is associated with decreased survival in resected pancreatic cancer; however, it is not an independent prognostic factor. + + + + 24112413 + + + + + + + + 2016 + 1 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 2 + 11 + 42 + 0 + + + + + + + 18 + the present study indicated that the mechanism of action of miR-146b-5p in GBC involves the regulation of EGFR expression. + + + + 25760482 + + + + + + + + 2016 + 1 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 2 + 11 + 9 + 0 + + + + + + + 18 + Two patients had simultaneous T790M EGFR or PIK3CA mutation alongside EGFR activating mutation. + + + + 25724261 + + + + + + + + 2016 + 1 + 2 + 10 + 1 + 0 + + + + + + + + + 2016 + 1 + 2 + 10 + 44 + 0 + + + + + + + 18 + Either ligand-independent or ligand-induced EGFR phosphorylation was inhibited in lung cancer cells that strongly expressed DDX3X. + + + + 25343452 + + + + + + + + 2015 + 12 + 26 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 26 + 11 + 55 + 0 + + + + + + + 18 + Patients with any EGFR, CK19, CK20 or survinin positivity in their peripheral blood obtain less benefit from radiotherapy. + + + + 25854400 + + + + + + + + 2015 + 12 + 26 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 26 + 11 + 27 + 0 + + + + + + + 18 + ErbB2 and ErbB3 homodimers are endocytosis deficient owing to the lack of endocytic codes. Interestingly, EGFR-ErbB2 or EGFR-ErbB3 heterodimers are also endocytosis deficient + + + + 25588832 + + + + + + + + 2015 + 12 + 26 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 26 + 10 + 56 + 0 + + + + + + + 18 + EGF receptor signaling is regulated according to circadian rhythm + + + + 25278152 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 58 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small cell lung cancer. + + + + 25684509 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 24 + 0 + + + + + + + 18 + These results suggest that the PKC pathway and PDGFR/EGFR transactivation pathway play important roles in HCA2-mediated Akt activation. + + + + 25375133 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 23 + 0 + + + + + + + 18 + Combined L-EGFR + H-Beclin1 expression may represent a biomarker in identifying relatively favorable clinical presentations and prognosis, thus envisaging possible EGFR/Beclin1-targeted therapies. + + + + 25821789 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 19 + 0 + + + + + + + 18 + In surgically resected primary USP8-mutated tumor cells, USP8 knockdown or blocking EGFR effectively attenuates ACTH secretion. Inhibition of USP8 or EGFR is promising for treating USP8-mutated corticotrophin adenoma. + + + + 25675982 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 19 + 0 + + + + + + + 18 + Afatinib significantly improved PFS versus cisplatin/pemetrexed in Japanese EGFR mutation-positive lung adenocarcinoma patients. + + + + 26094656 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 5 + 0 + + + + + + + 18 + Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors. + + + + 25656847 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 11 + 3 + 0 + + + + + + + 18 + EGFR played an important role in docetaxel-resistant prostate cancer cells. + + + + 24888374 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 10 + 55 + 0 + + + + + + + 18 + This expert group recommends testing for KRAS and NRAS status in all patients with metastatic CRC being considered for anti-epidermal growth factor receptor (anti-EGFR) therapy + + + + 25373533 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 10 + 43 + 0 + + + + + + + 18 + Here we demonstrated a new AFM technique-topography and recognition (TREC) imaging-to simultaneously obtain highly sensitive and specific molecular recognition images and high-resolution topographic images of EGFR on single breast cancer cells. + + + + 26002322 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 10 + 23 + 0 + + + + + + + 18 + Demonstrate the essential role of EGFR/Akt/IkappaBbeta/NF-kappaB pathway in the inhibitory effect of PA-MSHA on invasion and metastasis of HCC through suppressing EMT. + + + + 25066210 + + + + + + + + 2015 + 12 + 19 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 19 + 10 + 17 + 0 + + + + + + + 18 + First- or second-line afatinib demonstrated preliminary activity and manageable safety in EGFR FISH-positive patients with advanced non-small-cell lung cancer. + + + + 25514804 + + + + + + + + 2015 + 12 + 12 + 10 + 2 + 0 + + + + + + + + + 2015 + 12 + 12 + 12 + 5 + 0 + + + + + + + 18 + Changes in plasma EGFR mutation status can be successfully assessed using the peptide nucleic acid-zip nucleic acid polymerase chain reaction clamp method and can serve as an independent outcome predictor. + + + + 25514801 + + + + + + + + 2015 + 12 + 12 + 10 + 2 + 0 + + + + + + + + + 2015 + 12 + 12 + 12 + 5 + 0 + + + + + + + 18 + The lack of response to EGFR inhibitors in EGFR mutated lung cancer may indicate that tumor differentiation affects tumor dependency on EGFR as a driver oncogene. + + + + 25700797 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 52 + 0 + + + + + + + 18 + Data suggest that the mechanism of gamma-H2AX on the angiogenic activity of hepatocellular carcinoma (HCC) might go through EGFR/HIF-1alpha/VEGF pathways under hypoxic conditions. + + + + 25537504 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 48 + 0 + + + + + + + 18 + EGFR signaling defines Mcl1 survival dependency in neuroblastoma. + + + + 25756510 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 32 + 0 + + + + + + + 18 + nicotine contributes to the progression and erlotinib-resistance of the NSCLC xenograft model via the cooperation between nAChR and EGFR. + + + + 25670150 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 10 + 0 + + + + + + + 18 + In this study, we demonstrate that 5a-induced cell cycle arrest and apoptosis by inhibiting EGFR and HER2 activity and downstream activation of PI3K/Akt and MEK/Erk pathways. + + + + 25766325 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 10 + 0 + + + + + + + 18 + study provides a new molecular mechanism to regulate EGFR signaling through modulation of MIG6 by DNAJB1 as a negative regulator. + + + + 26239118 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 11 + 5 + 0 + + + + + + + 18 + The majority of patients with advanced lung adenocarcinomas harboring EGFR exon20ins do not respond to EGFR tyrosine kinase inhibitors therapy + + + + 26096453 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 10 + 57 + 0 + + + + + + + 18 + the findings suggest that the observed EGF response underlies an EGFR integrin cross-talk under recruitment of receptor proximal FAK and Src, and MAP kinase and p190RhoGAP as receptor distal events. + + + + 26079101 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 10 + 50 + 0 + + + + + + + 18 + Brain metastases are frequent in advanced EGFR-mutated or ALK-rearranged non-small-cell lung cancers. + + + + 25682925 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 10 + 50 + 0 + + + + + + + 18 + There was a positive association between EGFR mutation and the presence of malignant pleural effusion in lung cancer. + + + + 25239875 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 10 + 32 + 0 + + + + + + + 18 + Chronic nicotine exposure because of cigarette smoking mediates resistance to EGFR-TKI via an EGFR signal. + + + + 25704955 + + + + + + + + 2015 + 12 + 5 + 10 + 1 + 0 + + + + + + + + + 2015 + 12 + 5 + 10 + 31 + 0 + + + + + + + 18 + ErbB2 and EGFR have previously been considered as undruggable targets for CART cells. + + + + 26330166 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 11 + 30 + 0 + + + + + + + 18 + we describe the generation of CARs able to tune T-cell activity to the level of EGFR expression in which a CAR with reduced affinity enabled T cells to distinguish malignant from nonmalignant cells + + + + 26330164 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 11 + 30 + 0 + + + + + + + 18 + EGFR and KRAS mutation were associated with non-small cell lung carcinoma. + + + + 25936883 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 11 + 22 + 0 + + + + + + + 18 + EGFR gene promoter methylation is associated with secondary resistance to gefitinib. + + + + 25936882 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 11 + 22 + 0 + + + + + + + 18 + EGFR-activating mutation is associated with the treatment outcome of first-line chemotherapy in advanced non-small cell lung cancer patients. + + + + 25800568 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 59 + 0 + + + + + + + 18 + Experimental data showed upregulation of the selected EGFR cascade( Akt, nuclear factor kappa B p50 ) stromal expression of EGFR, and nuclear localization of COX-2 in metaplastic gland cells of laryngeal cancer tissue sample + + + + 25736926 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 56 + 0 + + + + + + + 18 + Suggest that TXNIP plays a critical role in anti-Her-1/Her-2 treatment and may be a potential prognostic marker in breast cancer. + + + + 25605021 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 40 + 0 + + + + + + + 18 + we discuss ligand-independent EGFR signal transduction by oncogenic EGFR mutants and EGFRwt, and review the interplay between EGFRwt and EGFRvIII + + + + 26282175 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 21 + 0 + + + + + + + 18 + Seventeen different types of pathogenic EGFR-TK domain mutations were detected in 55 of the 210 samples (26%). + + + + 25751592 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 17 + 0 + + + + + + + 18 + to gain insight into the molecular circuitries of EGFR induced hepatocarcinogenesis diverse computational approaches were employed. This revealed master regulatory proteins and permitted network constructions of 82 disease regulated proteins + + + + 25872475 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 17 + 0 + + + + + + + 18 + WM130 could inhibit cell proliferation, invasion, migration and induced apoptosis in HCC cells by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. + + + + 26259512 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 17 + 0 + + + + + + + 18 + CEA response after 1 month of EGFR-TKI therapy could be a useful marker, worthy to further studies, as early predictor of treatment outcome in EGFR wild-type/unknown unselected NSCLC cases for which no molecular predictor is yet available + + + + 25731731 + + + + + + + + 2015 + 11 + 28 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 28 + 10 + 9 + 0 + + + + + + + 18 + To study the prognostic factors influencing survival after recurrence, EGFR mutations were prospectively evaluated in 594 patients who underwent curative surgical resection for pulmonary adenocarcinoma. + + + + 24760387 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 11 + 58 + 0 + + + + + + + 18 + Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer. + + + + 25324142 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 11 + 47 + 0 + + + + + + + 18 + this is the first study focused on the effect of statins in selected patients with advanced-stage NSCLC harbouring KRAS mutation treated with EGFR-TKIs. A randomized prospective clinical trial should be conducted to confirm our results in the future. + + + + 25702091 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 11 + 41 + 0 + + + + + + + 18 + EGFR and IGF-1R appear to be overexpressed in a subset of ampullary adenocarcinomas and strong membranous expression of EGFR is an independent predictor for overall survival in patients with AA. + + + + 26165226 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 11 + 24 + 0 + + + + + + + 18 + IGF-1R expression was a negative predictive factor for a response to EGFR-TKIs in NSCLC patients harboring activating EGFR mutations. + + + + 25617986 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 11 + 23 + 0 + + + + + + + 18 + KRAS and EGFR co-mutation was detected in one case. PPMA patients with ALK rearrangements or KRAS mutation represent a unique subtype in Non-Small-Cell Lung Carcinoma + + + + 25813151 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 52 + 0 + + + + + + + 18 + These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions. + + + + 25748238 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 43 + 0 + + + + + + + 18 + Data suggest that protein tyrosine phosphatase non-receptor type 6 (SHP-1) may interact with EGF receptor (EGFR) to inhibit proliferation. + + + + 22797910 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 38 + 0 + + + + + + + 18 + LRIG1 is frequently methylated in human CRC and consequent mRNA and protein downregulation may contribute to tumor growth by activating EGFR/AKT signaling + + + + 26159916 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 27 + 0 + + + + + + + 18 + Data suggest expression of p110 splice variant of EGFR (potential EGFR antagonist) is up-regulated on surface of chorionic villi of pre-eclampsia as compared to that of normal term birth; EGF blocks cell death/apoptosis of cytotrophoblast cell line. + + + + 25589361 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 24 + 0 + + + + + + + 18 + we suggest that Musashi-1, Lgr5, and pEGFR are overexpressed in human SIAs and may play roles in human SIA carcinogenesis and progression. + + + + 25773390 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 22 + 0 + + + + + + + 18 + EGFR L858R mutation is associated with lung adenocarcinoma patients with dominant ground-glass opacity + + + + 25582278 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 22 + 0 + + + + + + + 18 + miR-129, EGFR, and MMP9 appear to be promising therapeutic targets for preventing the metastasis of non-small cell lung cancer + + + + 25716201 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 14 + 0 + + + + + + + 18 + in pulmonary nodules anti-EGFR antibody reduced the positivity to estrogen and progesterone receptors which enhance survival of LAM cells and Snail expression + + + + 25699271 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 12 + 0 + + + + + + + 18 + AR, EGFR, and BRCA1 might be unique biomarkers for targeted therapy and prognosis in TNBC. + + + + 25695063 + + + + + + + + 2015 + 11 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 11 + 21 + 10 + 11 + 0 + + + + + + + 18 + The P2 motif was required for the NS5A-mediated disruption to EGFR trafficking. + + + + 25872741 + + + + + + + + 2015 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 14 + 11 + 0 + 0 + + + + + + + 18 + Low-dose erlotinib is not recommended for fit patients with NSCLC harbouring EGFR mutations. + + + + 26174465 + + + + + + + + 2015 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 14 + 10 + 55 + 0 + + + + + + + 18 + In comparing Han and Uighur groups in China, exon 19 deletion was more common than L858R in exon 21 in Uighur patients. In Han patients, EGFR-sensitive mutations occurred in female, never-smoking patients with well-differentiated tumors; but for Uighur patients only smoking history showed an obvious correlation. + + + + 25886900 + + + + + + + + 2015 + 11 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 14 + 10 + 42 + 0 + + + + + + + 18 + TGF-alpha level correlated with efficacy, and EGFR overexpression might predict cetuximab efficacy. + + + + 25234930 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 11 + 47 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR) is prevalently amplified or overexpressed in distal colorectal cancers. + + + + 26145760 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 11 + 38 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have been shown to improve the prognosis of EGFR-mutated (exon 19/21) non-small cell lung carcinoma (NSCLC). Positive EGFR mutation status is associated with NSCLC in non-smokers. + + + + 25216867 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 11 + 4 + 0 + + + + + + + 18 + Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signaling networks. + + + + 25503978 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 10 + 59 + 0 + + + + + + + 18 + EGFR-mutant allele-specific imbalance is a significant event in non-small cell lung cancer, specifically associated with EGFR exon 19 deletions + + + + 26047622 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 10 + 52 + 0 + + + + + + + 18 + EGFR mutations were not a prognostic factor in patients with surgically resected non-small cell lung cancer. (Meta-analysis) + + + + 25162713 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 10 + 39 + 0 + + + + + + + 18 + SUMO-1 modification may affect the transcriptional activity of EGFR + + + + 26244656 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 10 + 27 + 0 + + + + + + + 18 + In addition, erlotinib therapy would be preferable in NSCLC patients with BM and EGFR mutation, especially those with exon 19 deletion. + + + + 25208818 + + + + + + + + 2015 + 11 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 11 + 7 + 10 + 25 + 0 + + + + + + + 18 + Continuation of EGFR inhibitor gefitinib after radiological disease progression on first-line gefitinib did not prolong progression-free survival in patients who received platinum-based doublet chemotherapy. + + + + 26159065 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 11 + 37 + 0 + + + + + + + 18 + These data suggested that Ets-2, a genuine cancer-specific transcription factor, is actively involved in EGFR kinase-induced hTERT overexpression pathway in lung cancer cells. + + + + 25680408 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 11 + 16 + 0 + + + + + + + 18 + EGFR expression correlates negatively with BRCA1, whereas miR-146a levels increase with BRCA1. + + + + 25417703 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 37 + 0 + + + + + + + 18 + EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1. + + + + 26071255 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 25 + 0 + + + + + + + 18 + Molecular docking simulations study revealed the genetic basis for EGFR drug resistance towards gefitinib and the ways for its reversal. + + + + 25091415 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 23 + 0 + + + + + + + 18 + DNa mutational analysis in lebanese population shows that mutations of EGFR and KRAS are present in 8.5% and 37.7% respectivement in lung adenocarcinoma. + + + + 25120214 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 23 + 0 + + + + + + + 18 + Overexpression of pEGFR and pAKT may predict the response rate in RASw/t patients treated with anti-EGFR mAb. + + + + 26171935 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 23 + 0 + + + + + + + 18 + Assessment of EGFR mutations in circulating tumor cell preparations from non-small-cell lung carcinoma patients is a very sensitive and specific diagnostic tool. + + + + 25137181 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 10 + 0 + + + + + + + 18 + The BIM polymorphism is not associated with EGFR mutant lung cancer. + + + + 25384174 + + + + + + + + 2015 + 10 + 31 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 31 + 10 + 7 + 0 + + + + + + + 18 + To investigate whether functional polymorphisms of EGFR and its ligands genes (EGF and TGFA) were associated with ILD. + + + + 24819665 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 11 + 22 + 0 + + + + + + + 18 + EGFR is overexpressed in Bruneian lung cancer patient. + + + + 25640358 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 11 + 12 + 0 + + + + + + + 18 + ACh-induced activation of EGFR/PI3K/AKT pathway and subsequent IL-8 upregulation may be one of the important mechanisms of M3R function. + + + + 25964092 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 10 + 47 + 0 + + + + + + + 18 + Case Report: combined large cell neuroendocrine carcinoma and adenocarcinoma with epidermal growth factor receptor mutation in a female patient who never smoked. + + + + 23518631 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 10 + 34 + 0 + + + + + + + 18 + Interaction of Cav1 with its receptor EGFR inhibits signaling and reduces cell proliferation, supporting a tumor suppressor function for Cav1. + + + + 25658354 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 10 + 34 + 0 + + + + + + + 18 + EGFL7 enhances EGFR-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells. + + + + 24945379 + + + + + + + + 2015 + 10 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 24 + 10 + 29 + 0 + + + + + + + 18 + Some of the most interesting studies involved third-generation epidermal growth factor receptor (EGFR) inhibitors in patients with EGFR mutations and resistance to agents such as erlotinib and gefitinib. + + + + 25768033 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 12 + 3 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR) is a common driver molecule in non-small cell lung cancer (NSCLC), making it an attractive target for the development of novel therapies in the current era of personalized medicine. + + + + 25768032 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 12 + 3 + 0 + + + + + + + 18 + Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. + + + + 25263444 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 12 + 0 + 0 + + + + + + + 18 + The majority of SDCs express AR, HER2, and/or EGFR. + + + + 24553861 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 12 + 0 + 0 + + + + + + + 18 + PHD3 loss sustains cell proliferation through the control of EGFR. + + + + 25420773 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 47 + 0 + + + + + + + 18 + PHD3 controls EGFR activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 and promotes the internalization of EGFR. + + + + 25420589 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 47 + 0 + + + + + + + 18 + The L858R/T790M EGFR mutant, when treated with sialidase or sialyltransferase inhibitor, showed an increase in tyrosine phosphorylation. + + + + 25971727 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 42 + 0 + + + + + + + 18 + EGFR mutation is associated with non-small cell lung cancer. + + + + 25098700 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 33 + 0 + + + + + + + 18 + the clinical profile of EGFR-mutant lung cancer carrying a pretreatment nongermline T790M mutation was similar to that of sensitive EGFR-mutant lung cancer, except for an overrepresentation of never-smokers and brain metastasis + + + + 25450875 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 30 + 0 + + + + + + + 18 + These observations suggest that not only ERK1/2 but also Akt activity is essential to maintain Ets-1 in an active state. + + + + 26150526 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 22 + 0 + + + + + + + 18 + Data demonstrate that JAK2/STAT3 signaling is essential for EGFRvIII-driven migration and invasion by promoting focal adhesion and stabilizing the EGFRvIII/JAK2/STAT3 axis. + + + + 24861878 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 11 + 22 + 0 + + + + + + + 18 + EGFR mutation is associated with treatment response in non-small-cell lung cancer. + + + + 25100284 + + + + + + + + 2015 + 10 + 17 + 10 + 2 + 0 + + + + + + + + + 2015 + 10 + 17 + 10 + 24 + 0 + + + + + + + 18 + Cumulatively, the data reported here connect the function of EGFR to Chlamydia trachomatis attachment and development in the host cells. + + + + 25471819 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 11 + 54 + 0 + + + + + + + 18 + preclinical evaluation of genistein-derived EGFR inhibitors suggests that these compounds are much more potent sensitizers of cells to radiation than the parent isoflavonoid, genistein + + + + 25401399 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 11 + 36 + 0 + + + + + + + 18 + These findings should assist clinicians in assessing the likelihood of EML4-ALK rearrangements and EGFR mutations and understanding their biological implications in NSCLC. + + + + 25434695 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 11 + 14 + 0 + + + + + + + 18 + EGFR mutations were more frequently in high tumor differentiation. + + + + 24297623 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 10 + 52 + 0 + + + + + + + 18 + EGFR mutations are closely associated with a high response rate to lung cancer treatment with an EGFR tyrosine kinase inhibitor. + + + + 25577516 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 10 + 43 + 0 + + + + + + + 18 + Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase c-Cbl. + + + + 26055326 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 10 + 40 + 0 + + + + + + + 18 + study aimed at prospectively estimating the impact of EGFR intron 1 (CA)n variants on clinical outcome in KRAS exon 2 and BRAF wild-type chemo-refractory metastatic colorectal cancer patients + + + + 24513691 + + + + + + + + 2015 + 10 + 10 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 10 + 10 + 27 + 0 + + + + + + + 18 + In this study, we show that EGFR activation up-regulates FOXC1 expression via ERK- and PI3 K/Akt-mediated activation in basal-like breast cancer. + + + + 25124473 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 11 + 31 + 0 + + + + + + + 18 + The R776H mutation activates EGFR in a dimerization-dependent manner by preferentially adopting the acceptor position in the asymmetric dimer. + + + + 26101090 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 11 + 19 + 0 + + + + + + + 18 + DNA mutational analysis of EGFR mutation is a reliable test for diagnosing lung adenocarcinoma. + + + + 25964184 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 11 + 18 + 0 + + + + + + + 18 + Data indicate that lipid domains regulate transition rates between diffusion states of liganded epidermal growth factor receptor (EGFR). + + + + 25556089 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 11 + 7 + 0 + + + + + + + 18 + CD82 down-regulation could be a critical step involved in the EGFR over-expression and the stronger tumorigenic activity triggered by EGFR mutations + + + + 25912735 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 55 + 0 + + + + + + + 18 + Report EGFR gene amplification/protein expression in squamous cell carcinoma of the vulva. + + + + 26171917 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 55 + 0 + + + + + + + 18 + Afatinib administration in non small cell lung cancer patients with EGFR mutation were successful. + + + + 26051236 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 45 + 0 + + + + + + + 18 + RAB5C is identified as a new TBC1D16 target and showed that it regulates EGFR in melanoma cells. + + + + 26030178 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 45 + 0 + + + + + + + 18 + EGFR mutation status was associated with lepidic dominant histologic subtype of lung adenocarcinomas. + + + + 25605150 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 45 + 0 + + + + + + + 18 + investigated the involvement of the RAS/MEK/ERK and PI3K/AKT/mammalian target of rapamycin (mTOR) pathways on metabolic alteration in lung adenocarcinoma cell lines with activating EGFR mutations + + + + 26023239 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 45 + 0 + + + + + + + 18 + Findings implicate a prominent role for activating EGFR mutations in the pathogenesis of ISP and associated SNSCC. + + + + 25931286 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 45 + 0 + + + + + + + 18 + Our experimental findings suggest that afatinib is especially effective against NSCLC carrying an EGFR exon 19 deletion. + + + + 25862853 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 44 + 0 + + + + + + + 18 + Activation of sperm EGFR by light irradiation is mediated by reactive oxygen species. + + + + 24724551 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 42 + 0 + + + + + + + 18 + Lung adenocarcinomas with EGFR exon 20 insertion mutations were present in a considerable proportion of patients, had distinct clinicopathologic characteristics, and had different pathway activation patterns compared to classic EGFR activating mutations. + + + + 24419753 + + + + + + + + 2015 + 10 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 10 + 3 + 10 + 36 + 0 + + + + + + + 18 + we determined that high EGFR expression may underlie the aggressive mechanism of advanced gastric cancer with high ND. + + + + 25154973 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 51 + 0 + + + + + + + 18 + Patients with a high EGFR expression seemed to present worse cliniconeurological status. + + + + 26124364 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 45 + 0 + + + + + + + 18 + Out of the patients with EGFR mutation and advanced disease, only 38% received EGFR-tyrosine kinase inhibitor (TKI) in first-line therapy. + + + + 26124345 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 45 + 0 + + + + + + + 18 + Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma. + + + + 25885672 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 45 + 0 + + + + + + + 18 + This advancement represents a key step towards sensitive wide-field Raman endoscopic imaging of multiple biomarkers for early and accurate diagnosis of EGF receptor-expressing tumors of different internal organs. + + + + 25046405 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 40 + 0 + + + + + + + 18 + High EGFR expression is associated with non-small cell lung cancer. + + + + 24919575 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 21 + 31 + 0 + + + + + + + 18 + Tumor-suppressive miR206 inhibited dual signaling networks activated by MET and EGFR in lung squamous cell carcinoma. + + + + 25522678 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 20 + 40 + 0 + + + + + + + 18 + Expression profiling demonstrated that AREG-activated EGFR regulates gene expression differently than EGF-activated EGFR + + + + 25454348 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 19 + 57 + 0 + + + + + + + 18 + Immunohistochemical NK-1R and pEGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia. + + + + 25684939 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 16 + 36 + 0 + + + + + + + 18 + study indicates that polymorphisms in the EGFR gene are associated with glioma susceptibility in the Chinese population. + + + + 25514356 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 16 + 36 + 0 + + + + + + + 18 + EGFR tyrosine kinase inhibitors enhance the sensitivity of NSCLC cells to vATPase inhibitors by decreasing Hif-1alpha/Bnip3 expression. + + + + 25981168 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 16 + 13 + 0 + + + + + + + 18 + p120ctn down-regulation and EGFR overexpression are able to mimic human ESCC in a culture model + + + + 25529795 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 14 + 13 + 0 + + + + + + + 18 + Results suggest that GSK3b may function as a regulator of apoptosis and tumorigenesis in glioblastoma stem-like cell through EGFR and PP2A signalling + + + + 25344882 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 13 + 27 + 0 + + + + + + + 18 + Conclude that not only ERalpha, but also basal activities of EGFR and Src kinase are essential for Cd-induced signal transduction and activation of MAPK/ERK pathway for breast cancer cell proliferation. + + + + 26006730 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 13 + 19 + 0 + + + + + + + 18 + carbon monoxide-releasing molecule-2 mediated p38 MAPK and JNK1/2 activation via a c-Src/EGFR/PI3K/Akt pathway + + + + 25921464 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 13 + 18 + 0 + + + + + + + 18 + In our series of Caucasian women with advanced adenocarcinoma of the lung EGFR mutations seem to be associated with lower benefit from first-line platinum-based chemotherapy . + + + + 25300933 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 12 + 20 + 0 + + + + + + + 18 + Our platform, which combines experimental data from structure-function and bioinformatics analyses based on MAPK substrate similarities, provides a low-cost and rapid approach for the identification of novel aDUSP-interacting proteins. + + + + 25375676 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 11 + 48 + 0 + + + + + + + 18 + These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR hyperactivation in PDAC and that low CBL may define PDAC tumors likely to respond to erlotinib treatment. + + + + 25348515 + + + + + + + + 2015 + 9 + 26 + 10 + 4 + 0 + + + + + + + + + 2015 + 9 + 26 + 11 + 47 + 0 + + + + + + + 18 + results suggest that suPAR may function as an important paracrine signaling factor in EGFRvIII-positive GBMs, inducing an aggressive phenotype in tumor cells that are EGFRvIII-negative + + + + 25837250 + + + + + + + + 2015 + 9 + 12 + 10 + 1 + 0 + + + + + + + + + 2015 + 9 + 12 + 10 + 56 + 0 + + + + + + + 18 + The presence of well-differentiated components in lung adenocarcinoma, such as lepidic, papillary and acinar, indicates a higher EGFR mutation rate, while the solid and mucinous component indicate a lower EGFR mutation rate. + + + + 25550848 + + + + + + + + 2015 + 9 + 12 + 10 + 1 + 0 + + + + + + + + + 2015 + 9 + 12 + 10 + 47 + 0 + + + + + + + 18 + Rare and compound EGFR mutations may occur and may have implications for treatment that differ from classically activating mutations. + + + + 25228365 + + + + + + + + 2015 + 9 + 12 + 10 + 1 + 0 + + + + + + + + + 2015 + 9 + 12 + 10 + 28 + 0 + + + + + + + 18 + EGFR exon 18-21 mutations not found in Iranian prostate adenocarcinoma patients. + + + + 26299074 + + + + + + + + 2015 + 9 + 12 + 10 + 1 + 0 + + + + + + + + + 2015 + 9 + 12 + 10 + 26 + 0 + + + + + + + 18 + survivin and EGFR expression are useful prognostic markers of triple-negative breast cancer + + + + 24233638 + + + + + + + + 2015 + 9 + 5 + 10 + 6 + 0 + + + + + + + + + 2015 + 9 + 5 + 11 + 54 + 0 + + + + + + + 18 + Suppression of EGFR ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes. + + + + 25721765 + + + + + + + + 2015 + 9 + 5 + 10 + 6 + 0 + + + + + + + + + 2015 + 9 + 5 + 11 + 28 + 0 + + + + + + + 18 + Our findings provide insight into the diversity of mechanisms through which tumors acquire resistance to AZD9291 and highlight the need for therapies that are able to overcome resistance mediated by the EGFR C797S mutation. + + + + 25939061 + + + + + + + + 2015 + 9 + 5 + 10 + 6 + 0 + + + + + + + + + 2015 + 9 + 5 + 11 + 26 + 0 + + + + + + + 18 + In multivariable analyses, in both patients with EGFR-mutant and KRAS-mutant lung adenocarcinomas, advanced stage at the time of diagnosis was found to be independently associated with shorter survival. + + + + 25781862 + + + + + + + + 2015 + 9 + 5 + 10 + 6 + 0 + + + + + + + + + 2015 + 9 + 5 + 11 + 9 + 0 + + + + + + + 18 + Breast cancer patients with co-heightened EGFR/AKT1 gene copy numbers had a worse outcome than those with only high EGFR gene copy numbers. + + + + 25702787 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 11 + 31 + 0 + + + + + + + 18 + CREB silencing using RNA interference reduced basal levels of BCRP mRNA and diminished the induction of BCRP by EGF. Chromatin immunoprecipitation assays confirmed that a putative CRE site on the BCRP promoter bound p-CREB by a point mutation + + + + 25615818 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 11 + 8 + 0 + + + + + + + 18 + hypermethylation of the CpG dinucleotide in EGFR codon 790 leads to the C-->T transition mutation, causing resistance to EGFR-TKI inhibiting drugs. + + + + 25682017 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 10 + 53 + 0 + + + + + + + 18 + In endometrial adenocarcinomas a relatively weak positive correlation between EGFR expression and melatonin blood serum levels is observed. With that, there is a negative correlation between the blood levels of EGF and melatonin. + + + + 25416211 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 10 + 44 + 0 + + + + + + + 18 + Studies indicate that epidermal growth factor receptor (EGFR) T790M mutations is an independent, favorable prognostic factor for predicting surviva + + + + 23769347 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 10 + 19 + 0 + + + + + + + 18 + Data indicate that the response rate to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR mutation which was remarkably higher than that in EGFR wild-type patients. + + + + 23769345 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 10 + 19 + 0 + + + + + + + 18 + Date indicate there were no significant differences between the lung cancer patients with epidermal growth factor receptor (EGFR) exon 19 and 21 mutations for overall survival. + + + + 25404271 + + + + + + + + 2015 + 8 + 29 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 29 + 10 + 8 + 0 + + + + + + + 18 + This finding suggests that the EGFR T790M mutation-derived antigen could be a new target for cancer immunotherapy. + + + + 25532027 + + + + + + + + 2015 + 8 + 22 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 22 + 11 + 16 + 0 + + + + + + + 18 + Data suggest that expression of EGF, EGF receptor, and c-erb-B2/ERBB2 in gastric mucosa is up-regulated during (1) gastritis with Helicobacter pylori infection, (2) gastric cancer, and (3) gastric cancer with Helicobacter pylori infection. + + + + 25051417 + + + + + + + + 2015 + 8 + 22 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 22 + 11 + 5 + 0 + + + + + + + 18 + Nickel accumulation in lung tissues is associated with EGFR mutations, miR-21 expression, and a poor outcome in lung cancer never-smoking patients. + + + + 26026961 + + + + + + + + 2015 + 8 + 22 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 22 + 10 + 30 + 0 + + + + + + + 18 + We conclude that the decreased expression of the tumor-suppressive miR-23b/27b cluster enhanced cancer cell proliferation, migration and invasion in BC through direct regulation of EGFR and c-Met signaling pathways + + + + 25405368 + + + + + + + + 2015 + 8 + 22 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 22 + 10 + 19 + 0 + + + + + + + 18 + mtEGFR can be activated by pmEGFR through de novo synthesized palmitate to promote mitochondrial fusion and survival of cancer cells. + + + + 25483192 + + + + + + + + 2015 + 8 + 15 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 15 + 10 + 59 + 0 + + + + + + + 18 + RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. + + + + 25313011 + + + + + + + + 2015 + 8 + 15 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 15 + 10 + 44 + 0 + + + + + + + 18 + this study found a negative correlation between tumor thickness and membrane EGFR expression. + + + + 25304234 + + + + + + + + 2015 + 8 + 15 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 15 + 10 + 35 + 0 + + + + + + + 18 + EGF/EGFR axis triggers epithelial-mesenchymal transition in cholangiocarcinoma cells highlighting the key role of this pathway in CCA progression + + + + 24704591 + + + + + + + + 2015 + 8 + 15 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 15 + 10 + 25 + 0 + + + + + + + 18 + The increased expression of EGFR in LAM cells is not associated with EGFR gene amplification, although it may be a marker of disease progression; the role of this receptor in LAM pathogenesis should be further investigated. + + + + 26026095 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 11 + 39 + 0 + + + + + + + 18 + These findings support the hypothesis that increased levels of the VEGF and sVEGFR-1 and VEGF/SVEGFR-1 ratio may be associated with the pathogenesis of TA [threatened abortion ]. + + + + 25200689 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 11 + 24 + 0 + + + + + + + 18 + PCNA phosphorylation by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis + + + + 25825764 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 10 + 39 + 0 + + + + + + + 18 + activation of EGFR signaling by its ligand on MCF-7 cells is sufficient to increase epithelial-mesenchymal transition phenotypes, to inhibit apoptotic events and to induce the loss of cytokeratin expression. + + + + 25277187 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 10 + 35 + 0 + + + + + + + 18 + These results suggest that the Glioma CpG Island Methylator Phenotype epigenetically regulates EGFR signaling + + + + 25277177 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 10 + 35 + 0 + + + + + + + 18 + There are distinct functional differences between different EGFR mutations. The functional differences between different mutations argue for the development of mutation specific targeted therapies. + + + + 25754235 + + + + + + + + 2015 + 8 + 8 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 8 + 10 + 35 + 0 + + + + + + + 18 + Good safety in chemo-naive PS 2 patients with EGFR wild-type or unknown non-squamous NSCLC. + + + + 25925001 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 11 + 47 + 0 + + + + + + + 18 + It represents a potential therapeutic option against LM after failure of standard-dose EGFR-TKIs. + + + + 25921002 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 11 + 47 + 0 + + + + + + + 18 + Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of Epidermal growth factor receptor + + + + 25870120 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 32 + 0 + + + + + + + 18 + The presence of EGFR activating mutations should be included as an index in the prognostic models for lung adenocarcinoma patients with brain metastasis. + + + + 25453849 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 9 + 0 + + + + + + + 18 + EGFR-mutated patients tended to be female and non-smoker and experienced a prolonged OS suggesting a possible positive prognostic effect. c-MET mutations did not affect survival. Target therapy might be considered in EGFR and c-MET-mutated patients. + + + + 25453846 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 9 + 0 + + + + + + + 18 + Of 11 gefitinib responders, 6 patients were identified as having tumor with activating EGFR mutation. + + + + 25903122 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 7 + 0 + + + + + + + 18 + Among those with EGFR-sensitive mutation, the cumulative risk of brain metastasis was lower in the icotinib group. + + + + 25450275 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 6 + 0 + + + + + + + 18 + Data (including data from SZ95 sebocyte cell line) suggest sebocytes abundantly express EGFR with lower levels of erb-b2 receptor tyrosine kinases ERBB2 and ERBB3; expression of these receptors appears coordinated with lipogenesis in specific ways. + + + + 25889637 + + + + + + + + 2015 + 8 + 1 + 10 + 1 + 0 + + + + + + + + + 2015 + 8 + 1 + 10 + 6 + 0 + + + + + + + 18 + In tDNA, 50 mutations (36 EGFR, 5 ERBB2, 4 KRAS, 3 BRAF, and 2 PIK3CA) were identified, of which 26 were detected in cfDNA. These data demonstrate the feasibility and potential utility of mutation screening in the detection of a range of tumor biomarkers + + + + 25013125 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 12 + 5 + 0 + + + + + + + 18 + Re-examination of EGFR gene status should be considered to grasp a chance of erlotinib treatment after first line treatment. negative HGF staining could be a biomarker for longer PFS by erlotonib treatment. + + + + 25249428 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 12 + 5 + 0 + + + + + + + 18 + Results show how GPRC5A deficiency leads to dysregulated EGFR and STAT3 signaling and lung tumorigenesis. + + + + 25744720 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 42 + 0 + + + + + + + 18 + Our data indicated better efficacy of EGFR-TKI in Del-E746 than Del-L747. Deletional locations may affect EGFR-TKI efficacy. + + + + 25304185 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 38 + 0 + + + + + + + 18 + CUL4A regulated EGFR transcriptional expression. + + + + 25413624 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 32 + 0 + + + + + + + 18 + EGFR and KRAS mutations were present in adenocarcinoma of the lung but not squamous tumors. + + + + 24866168 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 30 + 0 + + + + + + + 18 + EGFRvIII-mediated radioresistance, but not chemoresistance, was also modulated by JAGGED1 + + + + 25514871 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 30 + 0 + + + + + + + 18 + In EGFR-mutant patients, frontline EGFR-TKI significantly reduced the sensitivity of subsequent chemotherapy compared with that of TKI-naive frontline chemotherapy. + + + + 25263853 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 14 + 0 + + + + + + + 18 + Demonstrate that Mig-6 could reverse gefitinib resistance through inhibition of EGFR/ERK pathway in non-small cell lung cancer cell lines. + + + + 25400829 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 14 + 0 + + + + + + + 18 + Suggest that curcumin reduced oral squamous carcinoma cell proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. + + + + 25400722 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 13 + 0 + + + + + + + 18 + the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with bone mineral density in white women, as conducted. + + + + 25396734 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 13 + 0 + + + + + + + 18 + These data suggest that GEF-induced autophagy functions as cytoprotective and indicates the potential therapeutic possibility of using CAM for GEF therapy. + + + + 25858318 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 13 + 0 + + + + + + + 18 + EGFR mutation is associated with drug resistance in non-small cell lung cancer. + + + + 24789720 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 11 + 9 + 0 + + + + + + + 18 + REVIEW: role of EGFR as a prognostic marker for postoperative patients and as a predictive marker for response to cytotoxic chemotherapy + + + + 25302015 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 58 + 0 + + + + + + + 18 + MiR-491-5p-induced apoptosis in ovarian carcinoma by inhibition of both BCL-XL and EGFR leading to BIM activation. + + + + 25299770 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 58 + 0 + + + + + + + 18 + The rationale for simultaneous targeting of EGFR and PDGFR. + + + + 25380967 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 58 + 0 + + + + + + + 18 + Phosphorylated ErbB1-4 and heregulin contribute to poorer patient prognosis in CRC. This heregulin-ErbB family member autocrine loop may be a candidate for targeted treatment of CRC. + + + + 25416285 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 58 + 0 + + + + + + + 18 + EGFR activation is regulated by integrin beta-1. Decreased Itgb1 leads to decreased EGFR activation. + + + + 24844558 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 57 + 0 + + + + + + + 18 + Epidermal growth factor receptor exon 20 mutations in non-small-cell lung cancer and resistance to EGFR-tyrosine kinase inhibitors + + + + 25146938 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 40 + 0 + + + + + + + 18 + Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase. + + + + 25210793 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 36 + 0 + + + + + + + 18 + Extracellular EGFR-activating mutations in glioblastoma enhance ligand-binding affinity without directly promoting EGFR dimerization. + + + + 25453753 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 36 + 0 + + + + + + + 18 + The activation is fully dependent on the transactivation of the epidermal growth factor receptor (EGFR). + + + + 25421240 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 34 + 0 + + + + + + + 18 + Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor + + + + 25521828 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 27 + 0 + + + + + + + 18 + Adenocarcinomas with ALK rearrangement appeared as solid masses with lobulated margins at CT, were more likely to be associated with lymphangitic metastasis, advanced ln metastasis, and pleural/ pericardial metastasis than were tumors with EGFR mutations. + + + + 25575117 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 27 + 0 + + + + + + + 18 + Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes. + + + + 25964481 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 27 + 0 + + + + + + + 18 + Exogenously expressed HER2 failed to associate with EGFR or HER3 in MDA-MB-231 cells, while overexpression of HER2 enhanced HER family dimerization in MCF-10A and MCF-7 cells + + + + 25935365 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 27 + 0 + + + + + + + 18 + GAB adaptor proteins play a role in ERBB3-independent activation of the PI3K pathway by mutant EGFR in EGFR-mutant human cell lines. + + + + 25596284 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 8 + 0 + + + + + + + 18 + These findings indicate that EGFR-mut tumors are likelier to be MPP-positive subtypes and that MPP may be a novel potential pathological marker of poor prognosis in Chinese LAC patients. + + + + 25236981 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 6 + 0 + + + + + + + 18 + These results suggest that miR-27a may have antiviral activity against enterovirus 71 by inhibiting EGFR. + + + + 25212431 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 6 + 0 + + + + + + + 18 + EGFR was found highly expressed in cancer tissues, and its knockdown inhibits growth and invasion of gastric cancer cells. + + + + 25394504 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 6 + 0 + + + + + + + 18 + Cetuximab activity in NSCLC patient-derived xenograft models was demonstrated clearly only in tumors that expressed high levels of EGFR, as defined by an IHC score of >/=200. + + + + 24947928 + + + + + + + + 2015 + 7 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 7 + 25 + 10 + 4 + 0 + + + + + + + 18 + expression of EGFR, CDKN2A and TP53 may be associated with tumour pathology but is not induced by HPV + + + + 25012870 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 16 + 19 + 0 + + + + + + + 18 + Studied structural changes induced upon binding by probing the solution conformations of full length exEGFR alone and bound to a cognate adnectin through HDX MS. + + + + 25223306 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 15 + 24 + 0 + + + + + + + 18 + EGFR interacted with GPRC5A and phosphorylated it in two conserved double-tyrosine motifs, Y317/Y320 and Y347/ Y350, at the C-terminal tail of GPRC5A. + + + + 25311788 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 15 + 24 + 0 + + + + + + + 18 + Grandinin significantly reduce malignant cell viability and effectively induces apoptosis of malignant lung cells by mediating phosphorylation down-regulation of cellular signaling proteins EGFR and AKT. + + + + 25337231 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 15 + 17 + 0 + + + + + + + 18 + Targeting MUC1-C inhibits mutant EGFR signaling and survival. + + + + 25189483 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 15 + 14 + 0 + + + + + + + 18 + N-glycosylation is a critical determinant of EGFR conformation + + + + 25805821 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 13 + 42 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase involved in the signaling pathways that regulate cell proliferation, apoptosis, angiogenesis, and invasion. + + + + 25303964 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 13 + 36 + 0 + + + + + + + 18 + Activating mutations of EGFR were observed in 28.6% of adenosquamous lung carcinoma patients and included deletions of 15 base-pairs in exon 19 in three cases and substitution of L861Q with coexistence of G719X mutation in one non-smoking male patient. + + + + 24575772 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 13 + 6 + 0 + + + + + + + 18 + The results suggest that considering IDO and EGFR as two indicators for breast cancer treatment or prognosis analysis provides a potential option of individual treatment for the portion of breast cancer patients with co-expression of IDO and EGFR. + + + + 25081660 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 12 + 59 + 0 + + + + + + + 18 + The association between EGFR gene copy number, KRAS status, and anti-EGFR antibody response in colorectal cancer cell lines, was evaluated. + + + + 24940619 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 11 + 49 + 0 + + + + + + + 18 + The treatment of HaCaT cells with Pep2-YAC induced phosphorylation, internalization, and degradation of EGFR and organization of signaling complexes. + + + + 25179402 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 11 + 42 + 0 + + + + + + + 18 + These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR + + + + 25209759 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 11 + 41 + 0 + + + + + + + 18 + Glyco-engineering of anti-EGFR antibodies could optimize their function and minimize their side effects. + + + + 25263334 + + + + + + + + 2015 + 7 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 7 + 4 + 11 + 41 + 0 + + + + + + + 18 + Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib. + + + + 25249545 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 50 + 0 + + + + + + + 18 + NTS/NTSR1 complex enhances breast tumor aggressiveness via EGFR/HER2/HER3 pathway. + + + + 25249538 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 50 + 0 + + + + + + + 18 + Both SH2 and GEF domains of GIV are required for the formation of a ligand-activated ternary complex between GIV, Galphai3, and EGFR. + + + + 25187647 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 46 + 0 + + + + + + + 18 + Theanine derivatives effectively suppress the growth of lung cancer cells in vitro, ex vivo and in vivo by targeting EGFR/VEGFR-Akt/NF-kappaB pathways. + + + + 25138052 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 46 + 0 + + + + + + + 18 + TrkB-EGFR-sortilin (TES) complex in exosomes has a function in the activation and migration of endothelial cells. + + + + 25037567 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 40 + 0 + + + + + + + 18 + EGFR plays an integral role in establishing the cellular context necessary for successful pregnancy via the activation of intricate signaling and transcriptional networks, thereby providing valuable insight into potential therapeutic targets. + + + + 24945252 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 23 + 0 + + + + + + + 18 + EGFR testing is requested in Israel routinely for all advanced NSCLC patients, regardless of histology. In most cases, systemic treatment is deferred until the results of this test are received. + + + + 24964874 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 19 + 0 + + + + + + + 18 + High EGFR expression is associated with glioma cell invasion. + + + + 25691332 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 13 + 18 + 0 + + + + + + + 18 + P53, EGFR and MGMT proteins play important roles in the occurrence and development of brain glioma. + + + + 25864751 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 12 + 34 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with hepatocellular carcinoma. + + + + 25338986 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 11 + 20 + 0 + + + + + + + 18 + RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR. + + + + 25178484 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 11 + 1 + 0 + + + + + + + 18 + Combined inhibition of nucleolin and ras prevents EGFR activation in glioblastoma cells, additively reducing tumorigenicity. + + + + 25261371 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 11 + 0 + 0 + + + + + + + 18 + P-cadherin is able to potentiate ligand-dependent signaling of insulin-like growth factor 1 receptor in malignant keratinocytes and epidermal growth factor receptor in dysplastic cells. + + + + 25322858 + + + + + + + + 2015 + 6 + 27 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 27 + 10 + 57 + 0 + + + + + + + 18 + The surface levels of three receptors [TfR, epidermal growth factor receptor (EGFR) and beta1 integrin] were tested and found to be reduced dependent on Escherichia coli EspG translocation. + + + + 24898821 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 12 + 29 + 0 + + + + + + + 18 + immunohistochemistry with the novel mutation-specific antibody could be used as a screening method to assess the EGFR L858R mutation status in primary lung adenocarcinoma. + + + + 25286755 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 12 + 21 + 0 + + + + + + + 18 + The cytoplasmic distribution of the EGFR staining appeared as a primary property of some squamous carcinoma cells + + + + 25279714 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 12 + 19 + 0 + + + + + + + 18 + Computational design of binding proteins to EGFR domain II. + + + + 24710267 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 11 + 40 + 0 + + + + + + + 18 + Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm. + + + + 25796184 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 11 + 27 + 0 + + + + + + + 18 + High expression of PD-L1 was associated with the presence of EGFR mutations in surgically resected NSCLC and was an independent negative prognostic factor for this disease. + + + + 25009014 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 11 + 27 + 0 + + + + + + + 18 + The mutant allele frequency may be a potential predictive factor of tyrosine kinase inhibitor treatment efficacy in patients with lung adenocarcinoma carrying the L858R mutation of the EGFR. + + + + 25009007 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 11 + 27 + 0 + + + + + + + 18 + the signaling pathways initiated from the EGFR vary depending on the ligands bound in a cell specific manner + + + + 25257250 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 11 + 22 + 0 + + + + + + + 18 + Our results indicated that the efficacies and outcomes of pemetrexed treatment in advanced lung adenocarcinoma patients with EGFR activating mutations were similar to those in patients with EGFR-wild-type genotype. + + + + 25301443 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 10 + 51 + 0 + + + + + + + 18 + Report EGFR expression/KRAS mutations and the effect of EGFR expression on stage, prognosis and response to conventional chemotherapy agents. + + + + 25911864 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 10 + 40 + 0 + + + + + + + 18 + High EGFR gene copy number or activating EGFR mutations may identify patient subgroups who receive increased clinical benefit from vandetanib in combination with docetaxel in second-line non-small cell lung cancer + + + + 25057173 + + + + + + + + 2015 + 6 + 20 + 10 + 1 + 0 + + + + + + + + + 2015 + 6 + 20 + 10 + 20 + 0 + + + + + + + 18 + Results shed some light on the mechanisms promoted by EGFRvIII that contribute to the malignant microenvironment in glioblastoma and identified that C/EBPb increased IL-6-driven angiogenesis and thereby glioblastoma progression. + + + + 25382637 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 14 + 33 + 0 + + + + + + + 18 + In lung adenocarcinomas, positive and partial positive TTF-1 expression has a significant positive correlation with EGFR mutations(exon 19 and 21). + + + + 24743427 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 14 + 12 + 0 + + + + + + + 18 + Study shows that EGFR mutation is detected in 47.7% of non-small-cell lung cancer and seems to be more frequent in patients 80 years and older. + + + + 25152277 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 13 + 9 + 0 + + + + + + + 18 + EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression. + + + + 25666625 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 13 + 9 + 0 + + + + + + + 18 + In OSCC, EGFR (E746-A750del) expression was found not to be associated with clinicopathological characteristics, prognostic factors, or social habits. HPV does not appear to be relevant to the survival of patients with OSCC. + + + + 24818747 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 11 + 48 + 0 + + + + + + + 18 + Oncogenic EGFR upregulated mir31 in lung carcinogenesis. + + + + 25050641 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 11 + 48 + 0 + + + + + + + 18 + Del 19 and L858R are the most frequent mutations in Pakistani lung adenocarcinoma patients. + + + + 25227801 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 11 + 13 + 0 + + + + + + + 18 + KLK6 promotes the proliferation of lung tumoral cells and restrains their apoptosis in vitro via ligand-dependent EGFR and was dependent on the protease-activated receptor 2. + + + + 24643912 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 10 + 59 + 0 + + + + + + + 18 + Data suggest that FccR and EGFR CA repeat polymorphisms may be associated with the outcome of metastatic colorectal cancer patients treated with cetuximab and FOLFIRI. + + + + 24828248 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 10 + 59 + 0 + + + + + + + 18 + Our study is the first to show radiosensitive biology of EGFR-mutated tumors in definitive CRT with curative intent and this finding could serve as a credible baseline estimate of EGFR-mutated population in stage III nonsquamous NSCLC. + + + + 25442336 + + + + + + + + 2015 + 6 + 6 + 10 + 2 + 0 + + + + + + + + + 2015 + 6 + 6 + 10 + 24 + 0 + + + + + + + 18 + A gene polymorphism with lung cancer was found, and EGFR Short genotype of cytosine adenine repeat number polymorphism was significantly associated with an increased risk of lung cancer. [review] + + + + 24495289 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 13 + 58 + 0 + + + + + + + 18 + miR-608 and miR-34a regulate chordoma malignancy by regulating EGFR, MET and Bcl-xL + + + + 24621885 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 13 + 2 + 0 + + + + + + + 18 + Results demonstrated that Kindlin-2 participates in EGFR signaling and regulates breast cancer progression. + + + + 25790908 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 12 + 36 + 0 + + + + + + + 18 + This study investigates the role of non-canonical EGFR pathway in resistance mechanism against cisplatin. Wild type and mutated (exon 19 deletion) EGFR-expressing cells responded similarly to cisplatin by showing MAPK-mediated EGFR phosphorylation. + + + + 25701783 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 11 + 6 + 0 + + + + + + + 18 + These results demonstrated that the evaluation of GPER1, EGFR and CXCR1 expression in papillary thyroid carcinoma may be useful in predicting the risk of lymph node metastasis + + + + 25031742 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 10 + 18 + 0 + + + + + + + 18 + Elevated expression of the ER-alpha36-EGFR/HER2 loops is one of the mechanisms by which ER-positive breast cancer cells escape tamoxifen therapy. + + + + 25203051 + + + + + + + + 2015 + 5 + 30 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 30 + 10 + 17 + 0 + + + + + + + 18 + Rociletinib was active in patients with EGFR-mutated NSCLC associated with the T790M resistance mutation. + + + + 25923550 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 12 + 13 + 0 + + + + + + + 18 + AZD9291 was highly active in patients with lung cancer with the EGFR T790M mutation who had had disease progression during prior therapy with EGFR tyrosine kinase inhibitors. + + + + 25923549 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 12 + 13 + 0 + + + + + + + 18 + T790M has a moderate effect on EGFR function but, when combined with other EGFR mutations it shows a remarkable enhancement of EGFR activity + + + + 25176975 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 11 + 38 + 0 + + + + + + + 18 + EGFR mutations are associated with non--small-cell lung cancer. + + + + 24370118 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 11 + 28 + 0 + + + + + + + 18 + Multiple primary malignancies occurred more frequently in patients with classic EGFR mutations, especially those with exon 19 deletions. + + + + 23608835 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 11 + 13 + 0 + + + + + + + 18 + In advanced non-small-cell lung cancer, folate receptor alpha (FRA) and EGFR are frequently coexpressed, but FRA and EGFR protein levels did not statistically correlate with each other + + + + 24993594 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 10 + 55 + 0 + + + + + + + 18 + Cx43 in Temozolomide (TMZ) resistance occurred by TMZ-resistant glioblastoma cells being able to activate epidermal growth factor receptor. + + + + 24675463 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 10 + 45 + 0 + + + + + + + 18 + Letter/Case Report: transformation to squamous cell carcinoma after tyrosine protein kinase resistance in EGFR-mutated non-small lung carcinoma. + + + + 25661795 + + + + + + + + 2015 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 23 + 10 + 5 + 0 + + + + + + + 18 + Findings suggest that adding chloroquine to EGF receptor (EGFR) and AKT2 inhibition has the potential to improve tumor responses in EGFR M+ non-small cell lung cancer (NSCLC). + + + + 24946858 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 13 + 1 + 0 + + + + + + + 18 + Bladder cancer cell lines shed soluble EGFR ectodomain. + + + + 25719831 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 12 + 55 + 0 + + + + + + + 18 + Mutation rate in domain of EGFR gene in investigated lung cancer population is in range with reported data in Caucasian race. + + + + 25122436 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 12 + 55 + 0 + + + + + + + 18 + The high concordance, specificity, and sensitivity demonstrate that EGFR mutation status can be accurately assessed using circulating-free tumor DNA. + + + + 25122430 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 12 + 55 + 0 + + + + + + + 18 + impact of epidermal growth factor receptor (EGFR) expression on prognosis of lip squamous cell carcinoma and its relation to clinicopathological features + + + + 24288349 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 12 + 54 + 0 + + + + + + + 18 + in EGFR mutation positive NSCLC patients treated with erlotinib a low number of CA repeats in intron 1 of the EGFR gene is a predictor for both longer progression free survival and overall survival. + + + + 25017413 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 12 + 26 + 0 + + + + + + + 18 + In NSCLC patients, positive EGFR mutation status may be associated with longer VDT, which seemed to have a slowly progressive and less-aggressive character. + + + + 24481317 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 11 + 40 + 0 + + + + + + + 18 + The treatment with EGFR inhibitor in combination with non-surgical combined modality in patients with hypopharyngeal carcinoma was well tolerated and resulted in encouraging laryngeal preservation survival rate. + + + + 25039274 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 11 + 24 + 0 + + + + + + + 18 + non-small cell lung cancer patients harboring rare mutations did not show consistent and favorable responses to EGFR TKI compared with those harboring classical mutations + + + + 23912954 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 11 + 17 + 0 + + + + + + + 18 + Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. + + + + 24980059 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 56 + 0 + + + + + + + 18 + The V843I mutation contributes to tumorigenesis by promoting phosphorylation of EGFR and its downstream signaling proteins. This mutation also appears to provide resistance to EGFR-TKIs through structural modification of EGFR. + + + + 25057940 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 56 + 0 + + + + + + + 18 + The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility + + + + 25140053 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 56 + 0 + + + + + + + 18 + The frequency and characteristics of EGFR gene mutation in Turkish non-small cell lung cancer patients + + + + 24973952 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 56 + 0 + + + + + + + 18 + Studies indicate the importance of the EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway in breast cancer. + + + + 25051360 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 8 + 0 + + + + + + + 18 + Immunohistochemical staining for EGFR, HER2 and IGF-1R was undertaken in 31 ovarian adult granulosa cell tumors. Tumor DNA was also analysed for mutations in the tyrosine kinase domain of EGFR (exons 18-21). + + + + 24206174 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 8 + 0 + + + + + + + 18 + EIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy. + + + + 25129346 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 5 + 0 + + + + + + + 18 + EGFR mutations in advanced NSCLC may be associated with higher ORRs to chemotherapy, but may have nothing to do with PFS and OS. + + + + 25043903 + + + + + + + + 2015 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 16 + 10 + 4 + 0 + + + + + + + 18 + analysis of activator-receiver preferences among ErbB proteins: EGFR/ErbB1 is the strongest receiver, followed by ErbB2 and then ErbB4; that cis-phosphorylation of EGFR and ErbB2 appears to be negligible + + + + 25468910 + + + + + + + + 2015 + 5 + 9 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 9 + 11 + 44 + 0 + + + + + + + 18 + This study suggests potential effects of SNPs of EGFR on the onset and susceptibility of biliary tract cancer. + + + + 25217982 + + + + + + + + 2015 + 5 + 9 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 9 + 10 + 44 + 0 + + + + + + + 18 + MCM7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor + + + + 25425645 + + + + + + + + 2015 + 5 + 9 + 10 + 2 + 0 + + + + + + + + + 2015 + 5 + 9 + 10 + 10 + 0 + + + + + + + 18 + mutations associated with pneumonic-type lung cancer relative to other lung cancer + + + + 25715252 + + + + + + + + 2015 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 2 + 12 + 56 + 0 + + + + + + + 18 + Cytological specimens are optimal for EGFR mutation analysis in advanced NSCLC. + + + + 25778309 + + + + + + + + 2015 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 2 + 12 + 28 + 0 + + + + + + + 18 + Gefitinib is an effective and well-tolerated therapeutic option for patients with locally advanced and metastatic NSCLC harboring EGFR mutations. + + + + 25778308 + + + + + + + + 2015 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 2 + 12 + 28 + 0 + + + + + + + 18 + Ubiquitinated EGFR interacts with Alix in mammalian cells and is involved in the regulation of multivesicular body sorting. + + + + 25510652 + + + + + + + + 2015 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2015 + 5 + 2 + 10 + 5 + 0 + + + + + + + 18 + Data showed that miR-203 levels were inversely correlated with the expression of two EGFR ligands, EREG and TGFA, and an EGFR dependent gene signature. + + + + 25004126 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 12 + 55 + 0 + + + + + + + 18 + Data indicate that combination of epidermal growth factor (EGFR) inhibitors with either the phosphatidylinositol 3-kinases inhibitor ZSTK474 or the mTOR serine-threonine kinases inhibitor sirolimus showed increased activity. + + + + 24964744 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 12 + 28 + 0 + + + + + + + 18 + approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1. + + + + 25512530 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 12 + 17 + 0 + + + + + + + 18 + Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma. + + + + 24487967 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 11 + 51 + 0 + + + + + + + 18 + No difference in gender and age regarding EGFR mutation status was observed on cytological as well as on histological material in patients with non-small cell lung cancer + + + + 25421919 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 11 + 33 + 0 + + + + + + + 18 + Data show that epidermal growth factor receptor (EGFR) single nucleotide polymorphisms (SNPs) rs12538371, rs845561, and rs6970262 were associated with head and neck squamous cell carcinoma (HNSCC) risk among never tobacco users. + + + + 25511740 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 11 + 33 + 0 + + + + + + + 18 + The expression of microRNA-200c in primary glioblastoma multiforme patients correlates with the level of EGFR amplification. + + + + 25058589 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 11 + 7 + 0 + + + + + + + 18 + Epidermal growth factor receptor overexpression, but not high EGFR copy number, is a poor prognostic factor in HER2-positive primary breast cancer. + + + + 25349977 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 10 + 25 + 0 + + + + + + + 18 + ligand-dependent constitutive activation of EGFR causes reduced ROS generation and increased antioxidant expression + + + + 25477514 + + + + + + + + 2015 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 25 + 10 + 25 + 0 + + + + + + + 18 + Mutations in EGFR gene is associated with neoplasms. + + + + 25119593 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 12 + 42 + 0 + + + + + + + 18 + EGFR relative overexpression and EGFR amplification were observed, respectively, in 50% and 20% of astrocytomas, while EGFRvIII was only found in GBMs (34.5%, p=0.005). + + + + 24170555 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 12 + 41 + 0 + + + + + + + 18 + Serum 25-hydroxyvitamin D levels correlate with EGFR mutational status in pulmonary adenocarcinoma + + + + 25030993 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 12 + 11 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with ameloblastoma. + + + + 25099616 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 12 + 11 + 0 + + + + + + + 18 + Complete pharmacologic EGFR/HER2 inhibition is required to reverse Src-dependent resistance to lapatinib in breast cancer. + + + + 24887236 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 12 + 2 + 0 + + + + + + + 18 + study was to address whether the ERBB3 mutations altering Val-104 were present in homologous amino acids of ERBB family genes EGFR, ERBB2 and ERBB4 in CRC. + + + + 24862237 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 11 + 52 + 0 + + + + + + + 18 + analysis of a mathematical model for how EGFR demonstrates linear signal transmission + + + + 24934872 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 11 + 52 + 0 + + + + + + + 18 + Presented data suggest that the transient formation of dynamic PTPD1/EGFR signalling complexes strengthens EGF signalling by promoting the spatial propagation of EGFR phosphorylated species + + + + 25062045 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 11 + 20 + 0 + + + + + + + 18 + BRAF overexpression could be an independent factor causing tumorigenesis in gliomas regardless of phospho-EGFR expression. + + + + 25618114 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 11 + 18 + 0 + + + + + + + 18 + The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of Lung adenocarcinoma in residents of southern Russia. + + + + 25775907 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 10 + 54 + 0 + + + + + + + 18 + There was no statistically significant difference in clinical parameters between patients with EGFR mutations in plasma and those without EGFR mutations. + + + + 23927790 + + + + + + + + 2015 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2015 + 4 + 18 + 10 + 23 + 0 + + + + + + + 18 + EGFR exon 19 deletions were associated with lung cancer. + + + + 24594201 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 42 + 0 + + + + + + + 18 + Geographically there is uniform distribution in the EGFR mutation frequency within India. + + + + 23979200 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 35 + 0 + + + + + + + 18 + EGFR mutation frequency is higher in Indian population vis-a-vis Caucasian population, but lower than that reported in the East Asian population. A significantly higher number of males also harbor EGFR mutations + + + + 23979199 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 35 + 0 + + + + + + + 18 + The observed benefit of addition of chemotherapy over TKI in EGFR mutation-positive group raises the question, can we offer the therapy of chemotherapy-TKI combination to EGFR mutation-positive lung cancer patients as shown in the present study. + + + + 23979198 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 35 + 0 + + + + + + + 18 + CONCLUSION: EGFR is expressed non-small-cell lung carcinomas Further studies to unravel the predictors for acquired genetic alterations of EGFR are needed. + + + + 23979197 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 35 + 0 + + + + + + + 18 + LL-37 induced TACE and EGFR activation, as well as TGF-alpha and MUC5AC mucin production by NCI-H292 cells. + + + + 24901072 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 13 + 18 + 0 + + + + + + + 18 + No statistically significant differences were observed in levels of EGF Receptor protein, when comparing breast cancer biopsies from male and female patients. + + + + 24656773 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 12 + 51 + 0 + + + + + + + 18 + Negative modulation of EGFR signaling by the chimeric ubiquitin ligases can inhibit malignancy of SPC-A1 cells and sensitize these cells to chemotherapy. + + + + 25573345 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 12 + 45 + 0 + + + + + + + 18 + Study shows that inactive EGFR, LAPTM4B, and the Sec5 subcomplex are required for basal and starvation-induced autophagy. LAPTM4B and Sec5 promote EGFR association with the autophagy inhibitor Rubicon, which in turn disassociates Beclin 1 from Rubicon to initiate autophagy. + + + + 25594178 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 11 + 54 + 0 + + + + + + + 18 + Erlotinib/capecitabine chemotherapy was significantly better in older Chinese patients with advanced Adenocarcinoma of the Lung with EGFR mutations. + + + + 25590835 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 11 + 53 + 0 + + + + + + + 18 + Suggest that activating mutations of EGFR, HRAS, and KRAS contribute to the pathogenesis of human seborrheic keratosis. + + + + 23739246 + + + + + + + + 2015 + 4 + 11 + 10 + 12 + 0 + + + + + + + + + 2015 + 4 + 11 + 10 + 38 + 0 + + + + + + + 18 + Preanalytical workflow optimisation may reduce errors in down-stream sequencing in EGFR mutation detection. + + + + 25430497 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 13 + 0 + 0 + + + + + + + 18 + A high EGFR copy number may predict benefit from tyrosine kinase inhibitors treatment for non-small-cell lung cancer patients with wild-type EGFR. + + + + 23557218 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 12 + 45 + 0 + + + + + + + 18 + new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines. + + + + 24802673 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 12 + 32 + 0 + + + + + + + 18 + High frequency of genetic mutations in EGFR, p53, and KRAS resulted in a high discrimination rate of synchronous multiple small adenocarcinoma clonality. + + + + 24643899 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 12 + 32 + 0 + + + + + + + 18 + T-cadherin regulates prostate cancer cell behavior by tuning the balance in EGFR/IGF-1R activity and enhancing the impact of IGF-1R + + + + 25381040 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 49 + 0 + + + + + + + 18 + These findings suggest that genomic deletion as well as additional regulatory mechanisms may contribute to EGFRvIII expression in HNSCC. + + + + 25658924 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 48 + 0 + + + + + + + 18 + Frequencey of baseline EGFR T790M mutations and correlation with poor response to EGFR inhibitors in lung cancer. + + + + 24478319 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 41 + 0 + + + + + + + 18 + Expression of EGFR and other markers were compared in primary squamous cell carcinoma of the breast and triple-negative invasive ductal carcinoma. + + + + 25119504 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 32 + 0 + + + + + + + 18 + The EGFR exon 19 and 21 coding sequences did not show any mutations. + + + + 24969895 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 28 + 0 + + + + + + + 18 + Activation of EGFR mutations identified in PT. + + + + 24969875 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 28 + 0 + + + + + + + 18 + we validated our method to successfully define tumor cell subpopulations containing distinct genetic and treatment resistance profiles and potentially mutually cooperative combinations of alterations in EGFR and other genes. + + + + 24893890 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 27 + 0 + + + + + + + 18 + Trp53 haploinsufficiency and EGFR overexpression cooperate in vivo to significantly increase neurofibroma and induce grade 3 peripheral nerve sheath tumorigenesis + + + + 24832557 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 27 + 0 + + + + + + + 18 + Expression of p-EGFR was found in this series to be strongly related to increase risk of recurrence and shorter overall survival. + + + + 23819610 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 11 + 4 + 0 + + + + + + + 18 + EGFR mutations are associated with response to chemotherapy in lung adenocarcinoma. + + + + 25589191 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 10 + 59 + 0 + + + + + + + 18 + Propranolol restricts the mobility of single EGF-receptors on the cell surface before their internalization. + + + + 24349439 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 10 + 36 + 0 + + + + + + + 18 + Report mutation-specific immunohistochemistry, using optimized procedures, as a reliable prescreening test for detecting EGFR mutations in lung adenocarcinoma. + + + + 23419122 + + + + + + + + 2015 + 4 + 4 + 10 + 2 + 0 + + + + + + + + + 2015 + 4 + 4 + 10 + 17 + 0 + + + + + + + 18 + Overexpression of EGFR predicts poor outcomes of medulloblastomas, small cell glioblastomas and primitive neuroectodermal tumors + + + + 24986561 + + + + + + + + 2015 + 3 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 3 + 28 + 13 + 15 + 0 + + + + + + + 18 + EGFR epigenetic activation has important implications in BRAFi resistance in melanoma + + + + 25243790 + + + + + + + + 2015 + 3 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 3 + 28 + 11 + 12 + 0 + + + + + + + 18 + Current approaches for predicting a lack of response to anti-EGFR therapy in KRAS wild-type patients. + + + + 25032217 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 12 + 44 + 0 + + + + + + + 18 + EGFR mutation is associated with lung adenocarcinoma. + + + + 25156817 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 12 + 39 + 0 + + + + + + + 18 + direct smears but also liquid-based cytology slides represent an effective preparation and storage medium for cytological material to be used for EGFR molecular testing. + + + + 25428205 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 12 + 38 + 0 + + + + + + + 18 + the combination of dovitinib + NVP-BEZ235 or dovitinib + AEE788 results in strong inhibition of tumor growth and a block in metastatic spread. Only these combinations strongly down-regulate the FGFR/FRS2/Erk and PI3K/Akt/mTOR signaling pathways + + + + 23343422 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 11 + 13 + 0 + + + + + + + 18 + ligand in the milieu of EGFRvIII-expressing GBM cells is likely to influence the EGFRvIII-Met interaction and resistance to treatment, and highlights a novel antagonistic interaction between EGFRwt and EGFRvIII in glioma cells + + + + 24362532 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 10 + 55 + 0 + + + + + + + 18 + EGFR gene mutations occurred more frequently in adenocarcinoma patients particularly with accompanying expression of TTF1 in non-small cell lung cancer. + + + + 25086987 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 10 + 55 + 0 + + + + + + + 18 + This model demonstrates the role of ErbB receptors underlying prolactinoma tumorigenesis and the feasibility of targeting these receptors for translation to treatment of refractory prolactinomas. + + + + 25375038 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 10 + 52 + 0 + + + + + + + 18 + Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1. + + + + 25550544 + + + + + + + + 2015 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 21 + 10 + 35 + 0 + + + + + + + 18 + augmentation of proinflammatory chemokines CXCL1/2, by potentiating NF-kappaB activation through EGFR-transactivated Akt, contributes to CXCR2-driven ovarian cancer progression + + + + 24376747 + + + + + + + + 2015 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 7 + 12 + 35 + 0 + + + + + + + 18 + An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression in larynx carcinoma. + + + + 25558642 + + + + + + + + 2015 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 7 + 12 + 20 + 0 + + + + + + + 18 + Our data indicate that EFIRM is effective, accurate, rapid, user-friendly, and cost effective for the detection of EGFR mutations in the saliva of patients with NSCLC. + + + + 25317990 + + + + + + + + 2015 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 7 + 11 + 54 + 0 + + + + + + + 18 + A functional link between MT4-MMP and the growth factor receptor EGFR. + + + + 25320013 + + + + + + + + 2015 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 7 + 11 + 5 + 0 + + + + + + + 18 + EGFR-activating mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 25456362 + + + + + + + + 2015 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2015 + 3 + 7 + 11 + 5 + 0 + + + + + + + 18 + EGFR mutation was a rare event in triple-negative breast cancers, but high EGFR copy number including EGFR amplification and high polysomy was relatively frequent and correlated with EGFR overexpression. + + + + 24406864 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 13 + 25 + 0 + + + + + + + 18 + Our data suggest a role for EGFR in DNA repair independent of DNAPKcs but dependent on ERCC1. + + + + 24780295 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 13 + 24 + 0 + + + + + + + 18 + EGFR or KRAS mutations were detected with xTAG liquidchip technology + + + + 24994038 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 13 + 9 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with sinonasal adenocarcinoma. + + + + 24338245 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 12 + 57 + 0 + + + + + + + 18 + EGFR mutations were found in 2.8% of lung adenocarcinomas with nodular ground-glass opacity. + + + + 24885886 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 12 + 52 + 0 + + + + + + + 18 + The unpredictable variability in EGFR CN and therefore in EGFR wild type/mutant allelic ratio justifies the implementation of sensitive methods to identify patients with EGFR mutated tumors + + + + 24885034 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 12 + 50 + 0 + + + + + + + 18 + High ErbB1 expression is associated with triple negative breast cancer. + + + + 23100016 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 12 + 28 + 0 + + + + + + + 18 + SOX4 may modulate expression of EGFR, expression of both SOX4 and EGFR defines a subset of cholangiocarcinoma patients with poor prognosis. + + + + 25181339 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 12 + 2 + 0 + + + + + + + 18 + tissue stiffening promotes GBM proliferation by spatially and biochemically amplifying EGFR signaling + + + + 25000176 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 11 + 52 + 0 + + + + + + + 18 + Suggest that EGFR gene amplification is associated with the severity of cytologic findings in cervical neoplasms. + + + + 24966959 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 11 + 52 + 0 + + + + + + + 18 + Report EGFR overexpression and ERK1/2 overexpression in Kazakh patients with esophageal squamous cell carcinoma. + + + + 24966948 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 11 + 52 + 0 + + + + + + + 18 + Aromatase is a candidate prognostic factor in patients with lung adenocarcinoma, especially in those with EGFR mutations, and may also be a beneficial therapeutic target in those patients. + + + + 24803578 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 11 + 52 + 0 + + + + + + + 18 + results suggest that the dual blockade of mutant EGFR and Met by crizotinib and a new generation EGFR-TKI may be promising for overcoming resistance to reversible EGFR-TKIs but careful assessment is warranted clinically. + + + + 24386407 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 10 + 24 + 0 + + + + + + + 18 + Combined inhibition of DRD2 and Epidermal Growth Factor Receptor (EGFR) led to synergistic tumoricidal activity as well as ERK suppression in independent in vivo and in vitro glioblastoma models. + + + + 24658464 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 10 + 19 + 0 + + + + + + + 18 + Overexpression of hMLH1 could be a new molecular marker to predict the response to EGFR-TKIs in NSCLCs. + + + + 24205245 + + + + + + + + 2015 + 2 + 28 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 28 + 10 + 10 + 0 + + + + + + + 18 + We observed EGFR alteration in a subset of cases with operable state gastric cancer and determined that it was associated with an unfavorable prognosis + + + + 23955257 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 12 + 47 + 0 + + + + + + + 18 + Compound 3, now renamed CO-1686, is currently in a phase I/II clinical trial in patients with EGFR(mut)-advanced NSCLC that have received prior EGFR-directed therapy. + + + + 24723450 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 12 + 25 + 0 + + + + + + + 18 + This may have profound implications for the anti-estrogen treatment of ER-positive breast cancers that have increased levels of EGFR. + + + + 24758408 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 11 + 58 + 0 + + + + + + + 18 + EGFR inhibitors suppressed keratinocyte expression of hBD2 and 3 induced by S. epidermidis. + + + + 24831548 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 11 + 53 + 0 + + + + + + + 18 + Mutational analysis of the EGFR gene in plasma samples is feasible with allele-specific PCR assays and represents a non-invasive supplement to biopsy analysis + + + + 24773774 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 11 + 40 + 0 + + + + + + + 18 + Egfr is significantly overexpressed in intrahepatic cholangiocarcinomas. + + + + 24867389 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 11 + 12 + 0 + + + + + + + 18 + Data suggest that combined inhibition of epidermal growth factor receptor and sphingosine kinase-1 has potential as an anticancer therapy in triple-negative breast cancer in which insulin-like growth factor-binding protein-3 expression is high. + + + + 24337110 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 11 + 2 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung adenocarcinoma. + + + + 24885205 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 10 + 50 + 0 + + + + + + + 18 + Computation biology data showed that EGFR and MET drive the cancer pathways in glioblastoma individuals. + + + + 24911613 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 10 + 47 + 0 + + + + + + + 18 + Positive EGFR mutations were shown to be associated with a better response to Docetaxel previously treated with a Paclitaxel-Platinum doublet for the treatment of Non-Small-Cell Lung Cancer in the Mexican population. + + + + 25059320 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 10 + 46 + 0 + + + + + + + 18 + Molecular expression of MMP-7, laminin c2 or EGFR, and their combinations, may be associated with gastric cancer tumor aggressiveness + + + + 24048760 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 10 + 44 + 0 + + + + + + + 18 + These increases in effector communication by cell surface receptors resulted in an increase in EGFR ubiquitylation with sustained ligand incubation. + + + + 25074934 + + + + + + + + 2015 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2015 + 2 + 21 + 10 + 17 + 0 + + + + + + + 18 + Rab11-dependent EGFR recycling has a role in synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M + + + + 25446083 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 13 + 15 + 0 + + + + + + + 18 + Suggest that the exocyst sec10, acting through EGFR, endocytosis, and the MAPK pathway is a candidate therapeutic target for acute kidney injury. + + + + 25298525 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 59 + 0 + + + + + + + 18 + EGFR signaling regulates the global metabolic pathway in EGFR-mutated LAD cells. + + + + 24928511 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 49 + 0 + + + + + + + 18 + we present the results of detecting EGFR mutations in individual sample types using three different low- or high-sensitivity techniques. + + + + 24891042 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 31 + 0 + + + + + + + 18 + Using multiple xenograft tumor models with varying EGFR expression, we determined the EGFR concentration in each model using a novel targeted agent (anti-EGFR affibody-IRDye800CW conjugate) along with a simultaneously delivered reference agent + + + + 25344226 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 7 + 0 + + + + + + + 18 + KRAS codons 12 and 13 mutation status was the first validated molecular biomarker for anti-EGFR antibodies + + + + 24956256 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 7 + 0 + + + + + + + 18 + Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor. + + + + 24759767 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 3 + 0 + + + + + + + 18 + In human coronary vascular smooth muscle, uPA induces uPAR-independent, domain-dependent smooth muscle cell proliferation through transactivation of EGFR by a plasmin-mediated, ADAM-induced, and HB-EGF-dependent process. + + + + 25082749 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 12 + 2 + 0 + + + + + + + 18 + Data indicate that metformin reverses epithelial-mesenchymal transition and decreases interleukin-6 signaling in EGFR-TKI-resistant lung cancer cells. + + + + 24644001 + + + + + + + + 2015 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 14 + 11 + 40 + 0 + + + + + + + 18 + EGF receptor response to different ligands may result from partial agonism for dimer formation, differences in the kinetic pathway utilized to generate activated receptor dimers, and biases in the formation of heterodimers versus homodimers. + + + + 25086039 + + + + + + + + 2015 + 2 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 7 + 12 + 41 + 0 + + + + + + + 18 + EGFR gene mutation status is significantly associated with serum carcinoembryonic antigen (CEA) status in advanced lung adenocarcinmoas;however, serum CEA is not an ideal predictor for EGFR mutation + + + + 25264883 + + + + + + + + 2015 + 2 + 7 + 10 + 2 + 0 + + + + + + + + + 2015 + 2 + 7 + 11 + 5 + 0 + + + + + + + 18 + Data indicate that the efficacy of gefitinib in patients with non-small cell lung cancer (NSCLC) harboring an epidermal growth factor receptor (EGFR) mutation does not differ according to their body surface area (BSA). + + + + 25173459 + + + + + + + + 2015 + 1 + 31 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 31 + 13 + 15 + 0 + + + + + + + 18 + We show the occurrence of EGFR mutations in patients with occupational asbestos exposure and also in those diagnosed with chronic obstructive pulmonary disease who have not been often investigated before. + + + + 24828666 + + + + + + + + 2015 + 1 + 31 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 31 + 10 + 36 + 0 + + + + + + + 18 + low rate of EGFR and KRAS mutations in this Belgian HNSCC population suggests that these genes will probably not play a major role in predicting response to anti-EGFR therapy in HNSCC + + + + 24899223 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 13 + 12 + 0 + + + + + + + 18 + EGFR/oncogene-driven cancers evolve during the course of the disease especially during targeted treatment. + + + + 24768581 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 12 + 41 + 0 + + + + + + + 18 + Lung adenocarcinoma with morule-like components is a distinct unfavorable prognostic and predictor for EGFR mutation. + + + + 24768118 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 12 + 41 + 0 + + + + + + + 18 + phosphorylation of DCBLD2 Y750 recruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of AKT, thereby enhancing EGFR-driven tumorigenesis + + + + 25061874 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 52 + 0 + + + + + + + 18 + in the study, 81.39% of head and neck squamous cell carcinomas(HNSCC) had 4 mutations:G2155C, G2176A, C2188G and G2471A - 2 are novel mutations in HNSCC; mutational frequency was associated with advanced stage of HNSCC, habits of tobacco/alcohol and age over 49 + + + + 24712396 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 49 + 0 + + + + + + + 18 + EGFR exon 19 insertions are sensitive to gefitinib treatment in lung cancer. + + + + 24736087 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + Germline EGFR T790M mutation is associated with metastasis in lung adenocarcinoma. + + + + 24736080 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + EGFR mutation is associated with treatment response in non-small-cell lung cancer. + + + + 24736073 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + EGFR gene T790M mutations are associated with lung cancer. + + + + 24736066 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + Patients with secondary T790M mutation at the time of progression having gradual or local progression after acquired resistance to EGFR-TKI benefit more from EGFR-TKI treatment beyond progression compared to those without T790M mutation. + + + + 24685306 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in epithelial ovarian cancer cell lines + + + + 24816687 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + No significant associations were found among GNAS1 T393C polymorphism and therapeutic efficacy of tyrosine kinase inhibitor in advanced non-small cell lung cancer with unknown EGFR mutation. + + + + 24758907 + + + + + + + + 2015 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 24 + 11 + 1 + 0 + + + + + + + 18 + EGFR transphosphorylation at Y845 plays an important role in its autophosphorylation and kinase activity. + + + + 24677053 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 13 + 16 + 0 + + + + + + + 18 + Results show that minor EGFR T790M mutations were present in 13% of EGFR-TKI-naive surgically resected lung adenocarcinomas and were associated with drug-sensitive EGFR mutations. + + + + 24842519 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 13 + 12 + 0 + + + + + + + 18 + CA-SSR-1 (intron-1 CA repeat) polymorphism in EGFR is a strong predictive factor for tumor recurrence and overall survival in patients with complete resected esophageal cancer without neoadjuvant or adjuvant therapy. + + + + 23377570 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 56 + 0 + + + + + + + 18 + Statistically significant differences were noted in the positive rates of EGFR genetic mutations in non-small cell lung cancer patients between Uygur and Han ethnic groups, with lower positive rates for the Uygur cases. + + + + 23803047 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 40 + 0 + + + + + + + 18 + Cases with ErbB pathway mutations have a worse outcome. + + + + 24997986 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 24 + 0 + + + + + + + 18 + Cetuximab-mediated antibody-dependent cell-mediated cytotoxicity activity may be correlated with the cell surface expression level of EGFR, regardless of the mutational statuses of KRAS and BRAF, in colorectal cancer. + + + + 24626880 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 24 + 0 + + + + + + + 18 + Data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells. + + + + 24840271 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 24 + 0 + + + + + + + 18 + Collectively, these studies demonstrated that Mycoplasma pneumoniae induces airway mucus hypersecretion by modulating the STAT/EGFR-FOXA2 signaling pathways. + + + + 25287927 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 24 + 0 + + + + + + + 18 + revealed that CKAP4 could associate with EGFR at basal status and the complex was reduced upon EGF stimulation, leading to release EGFR into cytoplasm + + + + 24838946 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 12 + 24 + 0 + + + + + + + 18 + normal CFTR suppresses airway epithelial IL-8 production that occurs via a stimulatory EGFR cascade. + + + + 23977375 + + + + + + + + 2015 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 17 + 10 + 47 + 0 + + + + + + + 18 + The mutations of EGFR and BRAF genes were not found in HER2-mutated patients with brain metastasis from non-small cell lung cancer. + + + + 23744164 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 14 + 23 + 0 + + + + + + + 18 + EGFR mutation detection is associated with non-small cell lung carcinoma. + + + + 24761893 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 14 + 13 + 0 + + + + + + + 18 + Of the 132 laryngeal squamous cell carcinoma specimens examined, only 1 specimen was found to be positive for EGFR exon 20 mutation, 2 specimens were positive for EGFR exon 21 mutation, and no samples were found to be positive for EGFR exon 19 mutation. + + + + 24646139 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 13 + 32 + 0 + + + + + + + 18 + There were no clearly pathogenic mutations in the EGFR gene in a cohort with thymic tumors. + + + + 24870739 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 13 + 17 + 0 + + + + + + + 18 + Can attenuate both protein and mRNA expressions of EGFR. + + + + 24707474 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 13 + 17 + 0 + + + + + + + 18 + Results demonstrated that the SPACE-HRM system we set up is a high sensitive assay that can be used for EGFR and KRAS allele enrichment and reliable detection + + + + 24883309 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 12 + 27 + 0 + + + + + + + 18 + These studies demonstrate the utility of MSOT to obtain volumetric images of ligand probe biodistribution in vivo to detect orthotopic pancreatic tumor lesions through active targeting of the EGF receptor + + + + 25217521 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 12 + 11 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with non-small cell lung cancer + + + + 24377577 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 11 + 25 + 0 + + + + + + + 18 + our data suggest that miRNA-34 inhibits EGFR signaling to regulate MMP7 expression in gastric carcinoma + + + + 24981249 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 11 + 25 + 0 + + + + + + + 18 + EGFR mutation is associated with squamous cell lung carcinoma. + + + + 24389448 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 11 + 6 + 0 + + + + + + + 18 + An uncommon insertion mutation in exon 19 of EGFR is associated with response to chemotherapy in lung adenocarcinoma. + + + + 24389445 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 11 + 6 + 0 + + + + + + + 18 + EGFR mutation is associated with response to chemotherapy in lung adenocarcinoma. + + + + 24389444 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 11 + 6 + 0 + + + + + + + 18 + In a cohort with non-small cell lung cancer, the mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with both in 3.81%. Mutation was more common in non-smokers than smokers, and in adenocarcinoma more than squamous cell carcinoma. + + + + 24870738 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 10 + 59 + 0 + + + + + + + 18 + phenotype was reproduced faithfully using four different BACs, indicating that EGFP can be used to target transcription factor function in transgenic mice. + + + + 25168898 + + + + + + + + 2015 + 1 + 10 + 10 + 2 + 0 + + + + + + + + + 2015 + 1 + 10 + 10 + 19 + 0 + + + + + + + 18 + SNPs were found in exon 20 of the EGFR gene in thyroid carcinoma showing thymus-like elements. + + + + 24934485 + + + + + + + + 2015 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 3 + 12 + 50 + 0 + + + + + + + 18 + EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms + + + + 24454858 + + + + + + + + 2015 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 3 + 11 + 42 + 0 + + + + + + + 18 + EGFR protein expression and high polysomy on chromosome 7 are frequent abnormalities in adrenal cortex carcinomas. + + + + 24457059 + + + + + + + + 2015 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 3 + 10 + 55 + 0 + + + + + + + 18 + Overexpression of EGFR was more observed in esophageal squamous cell carcinoma than in the control group. Overexpression of EGFR in ESCC tissues might play an important role in carcinogenesis and the progression of ESCC. + + + + 24883443 + + + + + + + + 2015 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2015 + 1 + 3 + 10 + 47 + 0 + + + + + + + 18 + The EGFR PCR test result was confirmed by a sensitive deep sequencing assay. + + + + 24586842 + + + + + + + + 2014 + 12 + 27 + 10 + 2 + 0 + + + + + + + + + 2014 + 12 + 27 + 14 + 2 + 0 + + + + + + + 18 + PS detection of low-frequency mutations may improve the KRAS predictive value for EGFR therapy selection. + + + + 24799053 + + + + + + + + 2014 + 12 + 27 + 10 + 2 + 0 + + + + + + + + + 2014 + 12 + 27 + 13 + 59 + 0 + + + + + + + 18 + Although the sensitive pyrosequencing method was used, no EGFR, KRAS or BRAF mutations could be found + + + + 24560515 + + + + + + + + 2014 + 12 + 27 + 10 + 2 + 0 + + + + + + + + + 2014 + 12 + 27 + 12 + 2 + 0 + + + + + + + 18 + Global functional profiles show that tumors driven by the EGFR oncogene often display an inflammatory response signature depending on the tissue type. + + + + 24166508 + + + + + + + + 2014 + 12 + 27 + 10 + 2 + 0 + + + + + + + + + 2014 + 12 + 27 + 11 + 14 + 0 + + + + + + + 18 + Deletion of Ctnnb1 significantly inhibits EGFR mutation dependent human lung tumor formation in mice. + + + + 25164010 + + + + + + + + 2014 + 12 + 27 + 10 + 2 + 0 + + + + + + + + + 2014 + 12 + 27 + 10 + 41 + 0 + + + + + + + 18 + FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations. + + + + 24550739 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 13 + 19 + 0 + + + + + + + 18 + Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. + + + + 24667376 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 12 + 52 + 0 + + + + + + + 18 + In Malaysian patients with non- small cell lung cancer, the EGFR mutation rate was similar to that in other Asian populations. + + + + 24528049 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 12 + 51 + 0 + + + + + + + 18 + Expression of S100A9 and EGFR closely correlates with cisplatin chemoresistance in bladder cancer. + + + + 24631944 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 12 + 39 + 0 + + + + + + + 18 + Data indicate that epidermal growth factor receptor (EGFR) is expressed in liver macrophages in both human hepatocellular carcinoma (HCC) and in a mouse HCC model. + + + + 25173978 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 12 + 4 + 0 + + + + + + + 18 + The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation + + + + 24928086 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 11 + 7 + 0 + + + + + + + 18 + Study shows that EGFR is a putative Linc00963 target in prostate cancer cell lines. + + + + 24691949 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 10 + 51 + 0 + + + + + + + 18 + EGFR mutation is associated with treatment efficacy in non-small cell lung cancer. + + + + 24748405 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 10 + 51 + 0 + + + + + + + 18 + an in vivo xenograft assay indicated that WK88-1 markedly suppressed tumor growth in the H1975 xenografts, highlighting the potential efficacy of WK88-1 for overcoming gefitinib resistance in NSCLCs harboring the T790M mutation in EGFR. + + + + 24789511 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 10 + 51 + 0 + + + + + + + 18 + genetic association study in population studied at academic medical center in Chicago: Data suggest that predominant subtype of lung adenocarcinoma is lepidic (44%; proposed IASLC/ATS/ERS classification) in patients with EGFR-mutant/deletions. + + + + 24571650 + + + + + + + + 2014 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 20 + 10 + 45 + 0 + + + + + + + 18 + EGFR and KRAS mutations are not uncommon in biliary tract carcinomas + + + + 24372748 + + + + + + + + 2014 + 12 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 6 + 13 + 0 + 0 + + + + + + + 18 + The EGFRvIII mutation is not present in HNSCC, therefore, EGFRvIII does not influence treatment response in HNSCC and is not a usable clinical prognostic marker. + + + + 25304797 + + + + + + + + 2014 + 12 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 6 + 12 + 59 + 0 + + + + + + + 18 + Twenty-eight squamous cell anal cancer patients (34%) showed an increase in EGFR gene copy number due to amplification (4%) or to polysomy (30%). + + + + 24122611 + + + + + + + + 2014 + 12 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 6 + 12 + 47 + 0 + + + + + + + 18 + A dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptor (EGFR)/HER2. + + + + 24554387 + + + + + + + + 2014 + 12 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 6 + 11 + 18 + 0 + + + + + + + 18 + EGFR overexpression was observed in 47% of non-small-cell lung carcinoma patients and was significantly associated with squamous cell carcinoma. + + + + 24185125 + + + + + + + + 2014 + 12 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 12 + 6 + 11 + 2 + 0 + + + + + + + 18 + the absence of both EGFR amplification and TERT promoter mutations is associated with longer survival in patients with glioblastomas + + + + 25150284 + + + + + + + + 2014 + 11 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 29 + 12 + 50 + 0 + + + + + + + 18 + surface up-regulation of NKG2D ligands by human epithelial cells in response to ultraviolet irradiation, osmotic shock, oxidative stress, and growth factor provision is attributable to activation of the epidermal growth factor receptor. + + + + 24718859 + + + + + + + + 2014 + 11 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 29 + 10 + 45 + 0 + + + + + + + 18 + Wild-type EGFR versus mutated EGFR was associated with early progression. The presence of abdominal metastasis was independently associated with early progression in metastatic non-small-cell lung carcinoma receiving EGFR-TKI. + + + + 24408092 + + + + + + + + 2014 + 11 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 29 + 10 + 35 + 0 + + + + + + + 18 + Over-expression of EGFR is closely correlated to poor prognosis in Tunisian patients with non-small cell lung adenocarcinoma. + + + + 24654822 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 13 + 37 + 0 + + + + + + + 18 + Weak power frequency magnetic field acting similarly to EGF stimulation, induces acute activations of the EGFR sensitive actin cytoskeleton motility in human amniotic cells. + + + + 24505297 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 12 + 37 + 0 + + + + + + + 18 + TIP30-induced downregulation of cyclin D1 transcription antagonizes EGFR signaling and suppresses tumorigenesis + + + + 25135222 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 12 + 34 + 0 + + + + + + + 18 + But minimal effects on EGFR phosphorylation. + + + + 25187431 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 11 + 50 + 0 + + + + + + + 18 + the expression of epidermal growth factor receptor was modulated by MUC4. + + + + 24582898 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 11 + 14 + 0 + + + + + + + 18 + An EGFR/HER2-Bispecific and enediyne-energized fusion protein shows high efficacy against esophageal cancer. + + + + 24664246 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 57 + 0 + + + + + + + 18 + PKP2 is a novel activator of the EGFR signaling pathway. + + + + 25113560 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 57 + 0 + + + + + + + 18 + HDAC6 inhibits rabaptin-5-mediated early endosome fusion in gastric cancer and therefore sustains growth stimulation by prolonging the activation of EGF receptor + + + + 25111897 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 57 + 0 + + + + + + + 18 + EGFR mutation is associated with lung cancer. + + + + 24568474 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 55 + 0 + + + + + + + 18 + in this work, we identified TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-kappaB and STAT3 pathways for lung cancers harboring mutant EGFR + + + + 24401319 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 6 + 0 + + + + + + + 18 + BCL2L11 mRNA expression is a biomarker of survival in EGFR-mutant NSCLC and can potentially be used for synthetic lethality therapies. + + + + 24493829 + + + + + + + + 2014 + 11 + 22 + 10 + 2 + 0 + + + + + + + + + 2014 + 11 + 22 + 10 + 6 + 0 + + + + + + + 18 + A novel role for Ack1 in diverting activated EGFR into a non-canonical degradative pathway. + + + + 24413169 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 45 + 0 + + + + + + + 18 + in lung adenocarcinomas, KRAS mutations are prevalent in male smokers; EGFR mutations are associated with female sex, nonsmoking and lepidic and micropapillary growth; TTF1 has a role in survival; BRAF mutations have roles in survival + + + + 23988776 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 40 + 0 + + + + + + + 18 + ALK rearrangements and EGFR mutations could coexist in a small subgroup of NSCLC. + + + + 24443522 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 38 + 0 + + + + + + + 18 + EGFR activation is involved in the downregulation of miR-145 in lung cancer cells + + + + 24535036 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 13 + 0 + + + + + + + 18 + Presence of variant forms of EGFR polymorphisms leads to a better breast cancer prognosis in Brazilian women with unilateral breast cancer and no distant metastases. + + + + 24629097 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 13 + 0 + + + + + + + 18 + Incidence of metastatic bone disease and brain metastases was not different between EGFR+, KRAS+ and WT patients + + + + 24529684 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 9 + 0 + + + + + + + 18 + The results identified Mgat5-mediated beta-1-6-GlcNAc branched N-glycosylation and following activation of EGFR as a potential novel upstream molecular event for PAK1-induced anoikis resistance in hepatoma cells. + + + + 23811795 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 13 + 4 + 0 + + + + + + + 18 + The altered dynamics of CD44 in the cell membrane demonstrated a further action of miR-7 in regulating the hyaluronic acid-dependent CD44/EGFR pathway. + + + + 24134702 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 12 + 49 + 0 + + + + + + + 18 + EGFR expression was correlated with mTOR expression and CD105 (a marker of microvascular density) expression in laryngeal squamous cell carcinoma. + + + + 24065188 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 12 + 18 + 0 + + + + + + + 18 + Suggest potential applications for the noninvasive detection of E746_A750del mutations in plasma samples from non-small cell lung cancer patients. + + + + 25291948 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 12 + 9 + 0 + + + + + + + 18 + Data suggest that detection of IgG responses to epidermal growth factor receptor (EGFR)-derived peptides may be a promising method for prognostication of NSCLC patients receiving gefitinib. + + + + 24497964 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 12 + 9 + 0 + + + + + + + 18 + The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. + + + + 24430869 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 11 + 15 + 0 + + + + + + + 18 + Ten patients with metastatic non-small cell lung cancer harboring an activating epidermal growth factor receptor mutation were included in this prospective observational study + + + + 24970910 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 11 + 12 + 0 + + + + + + + 18 + Data suggest that up-regulation of signaling via EGFR and ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) by leptin contributes to vascular dysfunction (as seen in obesity, metabolic syndrome, and diabetes). [REVIEW] + + + + 23688012 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 10 + 57 + 0 + + + + + + + 18 + Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation. + + + + 24365237 + + + + + + + + 2014 + 11 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 11 + 8 + 10 + 16 + 0 + + + + + + + 18 + Data indicate that cucurmosin can down-regulate epidermal growth factor receptor (EGFR) protein expression, but not at the messenger RNA level. + + + + 24518510 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 12 + 42 + 0 + + + + + + + 18 + PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor. + + + + 24534906 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 11 + 24 + 0 + + + + + + + 18 + IFNgamma and TNFalpha induced the phosphorylation of EGFR and the following phosphorylation of ERK, which is partly responsible for the suppressive effect of IFNgamma on TNFalpha-induced production of CTACK/CCL27. + + + + 24710735 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 10 + 57 + 0 + + + + + + + 18 + The presence of 41 known treatment linked EGFR mutations in exons 18, 19, 20 and 21 of the EGFR gene was tested in 209 Irish patients. + + + + 25226713 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 10 + 57 + 0 + + + + + + + 18 + Increased expression of SOS1 increases NFkappaB activation in several types of cancer cells, and ablation of SOS1 inhibits EGF-induced NFkappaB activation in these cells, indicating that SOS1 is a component of the pathway connecting EGFR to NFkappaB activation. + + + + 25071181 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 10 + 42 + 0 + + + + + + + 18 + Mechanistic model of EGFR endocytosis to determine the relative contributions of three parallel pathways of MIG6, ubiquitin ligase CBL and Sprouty2. + + + + 24445374 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 10 + 13 + 0 + + + + + + + 18 + EGFR has the potential to regulate the neuronal intrinsic regeneration and mTOR and PI3K/Akt pathway activation may have an important role in it. + + + + 23681769 + + + + + + + + 2014 + 10 + 25 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 25 + 10 + 10 + 0 + + + + + + + 18 + EGFR mutation is associated with response to erlotinib in non-small-cell lung cancer + + + + 23803112 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 13 + 38 + 0 + + + + + + + 18 + EGFR tyrosine kinase domain gene polymorphisms is associated with gastric cancer. + + + + 23803102 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 13 + 38 + 0 + + + + + + + 18 + Results suggest that decreased cell-cell adhesion and EGFR activation are drivers of cellular migration in epithelial cells. + + + + 25002532 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 13 + 35 + 0 + + + + + + + 18 + Complete abrogation of EGFR expression is a critical determinant of the therapeutic improvement induced by the cetuximab-namitecan combination. + + + + 24327272 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 13 + 6 + 0 + + + + + + + 18 + we report that Huh-7 cell line is an easy source for the particular gene of human epidermal growth factor isolation and we are also suggesting P. pastoris is an expression system to produce recombinant human epidermal growth factor + + + + 24413989 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 13 + 0 + 0 + + + + + + + 18 + Trafficking of EGFR and Grb2 in living HeLa cells stimulated with low, physiological concentrations of EGFR ligands, was analyzed.. + + + + 24259669 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 12 + 58 + 0 + + + + + + + 18 + The present study revealed that the EGFR mutation rate in Bangladeshi patients with adenocarcinoma of the lung was higher than in African-American, Arabian, and white Caucasian patients, and was lower than in East Asia + + + + 23299280 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 12 + 14 + 0 + + + + + + + 18 + Oncogenic activation of EGFRvIII in glioblastoma is likely maintained by a continuous EGFR-EGFRvIII-HB-EGF feedback loop. + + + + 24077285 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 11 + 27 + 0 + + + + + + + 18 + EGFR gene amplification/overexpression may be involved in carcinogenesis of the cervix and may be an early event during carcinogenesis. + + + + 24551297 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 11 + 4 + 0 + + + + + + + 18 + Report intratumoral distribution of EGFR-amplified and EGFR-mutated cells during the developmental process of lung adenocarcinoma. + + + + 24355440 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 11 + 2 + 0 + + + + + + + 18 + Report significant genotype-phenotype correlations between EGFR mutations and adenocarcinoma histologic subtypes and TITF-1/SP-A expression. + + + + 24370340 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 10 + 19 + 0 + + + + + + + 18 + These results suggest that co-inhibition of ROS1 and EGFR may be an effective strategy to combat resistance to targeted therapy in some ROS1 fusion-positive non-small cell lung cancer patients. + + + + 24349229 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 10 + 19 + 0 + + + + + + + 18 + The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway. + + + + 24953135 + + + + + + + + 2014 + 10 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 10 + 18 + 10 + 11 + 0 + + + + + + + 18 + hot spot mutations are associates with Merkel cell polyomavirus infection + + + + 24485957 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 12 + 25 + 0 + + + + + + + 18 + Activation of EGFR in response to diesel exhaust particles mediates the inflammation response in bronchial epithelial cells. + + + + 24555532 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 12 + 25 + 0 + + + + + + + 18 + autoantibodies against EGFR do not seem to be associated with the HER2 gene amplification phenomenon + + + + 24021599 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 12 + 11 + 0 + + + + + + + 18 + Tumors from NSCLC patients with EGFR-activating mutations that were intrinsically resistant to EGFR-TKIs expressed higher levels of CRIPTO1 compared with tumors from patients that were sensitive to EGFR-TKIs. + + + + 24911146 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 12 + 6 + 0 + + + + + + + 18 + The EGFRvIII-STAT3 pathway promotes cell migration and invasion by upregulating S100A11 in hepatocellular carcinoma. + + + + 24376686 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 11 + 48 + 0 + + + + + + + 18 + Our project proposed a novel function of EGFR in the regulation of glucose metabolism in chondrosarcoma cells and contributed to the development of therapeutic strategies for the clinical treatment of chondrosarcoma patient + + + + 24748236 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 11 + 48 + 0 + + + + + + + 18 + EGFR and PTGS2 expressions are prognostic molecular biomarkers correlated with clinical variables in colorectal cancer liver metastases. + + + + 24983372 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 11 + 33 + 0 + + + + + + + 18 + BK-mediated angiogenesis in endothelial cells involves the induction of the expression of VEGF associated with the activation of the NO/EGF-R/p21Ras/ERK1/2 MAP kinases signaling pathway + + + + 24960080 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 10 + 18 + 0 + + + + + + + 18 + Lactobacillus rhamnosus GG-derived protein p40-stimulated activation of EGFR mediates up-regulation of mucin production, which may contribute to the mechanisms by which p40 protects the intestinal epithelium from injury. + + + + 24895124 + + + + + + + + 2014 + 10 + 11 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 11 + 10 + 18 + 0 + + + + + + + 18 + In early enteropathogenic Escherichia coli infection EGFR phosphorylation contributes to host cell survival. EspF-driven caspase activation and consequent EGFR loss likely induce a precipitous increase in host cell death later in the infectious process. + + + + 24904077 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 12 + 7 + 0 + + + + + + + 18 + The incidence of EGFR gene mutations in the bone metastases was 75%. + + + + 23852459 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 12 + 6 + 0 + + + + + + + 18 + Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non-small-cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage. + + + + 24888607 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 11 + 45 + 0 + + + + + + + 18 + The frequency of EGFR mutation was adenocarcinoma in situ (62%), minimally invasive adenocarcinoma (60%), lepidic (77%), acinar (49%), papillary (50%), solid (28%), micropapillary (43%), and invasive mucinous adenocarcinoma (0%). + + + + 24961844 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 11 + 45 + 0 + + + + + + + 18 + High EGFR gene copy number is associated with non-small cell lung cancer. + + + + 24452282 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 11 + 27 + 0 + + + + + + + 18 + EGFR mutations do not appear to be involved in the development of primary adenocarcinoma of the urinary bladder. A subgroup of cases (36%), however, demonstrated increased gene copy number of EGFR by FISH. + + + + 23887300 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 10 + 41 + 0 + + + + + + + 18 + presence of an EGFR gene mutation was a predictive factor for the response to EGFR-TKI treatment in patients with resected stage I adenocarcinoma, but was not a prognostic factor + + + + 23609009 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 10 + 41 + 0 + + + + + + + 18 + EGFR and KRAS mutations are frequent in adenocarcinomas and are not prognostic factors for survival. + + + + 23357969 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 10 + 25 + 0 + + + + + + + 18 + MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer. + + + + 23206218 + + + + + + + + 2014 + 10 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 10 + 4 + 10 + 25 + 0 + + + + + + + 18 + LRIG1 evolved in bladder cancer as a rare feedback negative attenuator of EGFR. + + + + 24314030 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 46 + 0 + + + + + + + 18 + These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the activation of cyclin D1 by LMP1 in the carcinogenesis of NPC. + + + + 24499623 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 46 + 0 + + + + + + + 18 + Results suggest that WEB2086 and AG1478 are synergistic in ovarian cancer cells with high expression of both platelet-activating factor receptor (PAFR) and epidermal growth factor receptor (EGFR). + + + + 24886678 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 44 + 0 + + + + + + + 18 + These results might suggest a novel combined EGFR-autophagy modulation strategy, to overcome intrinsic glioblastoma radioresistance. + + + + 24691646 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 20 + 0 + + + + + + + 18 + EGFR expression was higher in normal tissues of BRCA1-mutated patients, and was further increased in cancer tissues; EGFR levels were also significantly elevated in ovarian cancer with promoter hypermethylation-mediated inactivation of BRCA1. + + + + 24321281 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 18 + 0 + + + + + + + 18 + Epidermal growth factor receptor down-regulation triggers human myoblast differentiation. + + + + 23967242 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 12 + 15 + 0 + + + + + + + 18 + direct sequencing overlooked EGFR mutation in a significant number of lung adenocarcinoma patients + + + + 24346097 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 10 + 59 + 0 + + + + + + + 18 + Expression of phosphorylated EGFR in cholesteatoma was significantly increased when compared with normal external ear canal epithelium. In cholesteatoma epithelium, a significant positive association was observed between p-EGFR and p-Akt expression. + + + + 23463347 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 10 + 33 + 0 + + + + + + + 18 + the high migratory activity of investigated pancreatic cancer cell lines is due to autocrine EGFR activation and possibly of other receptor tyrosine kinases + + + + 24810090 + + + + + + + + 2014 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 27 + 10 + 13 + 0 + + + + + + + 18 + EGFR exon 19 insertions is associated with response to gefitinib in lung cancer. + + + + 24419426 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 9 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 24419417 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 9 + 0 + + + + + + + 18 + EGFR mutation is associated with brain metastasis in pulmonary adenocarcinomas. + + + + 24419416 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 9 + 0 + + + + + + + 18 + EGFR G719X and L861Q mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 24419415 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 9 + 0 + + + + + + + 18 + EGFR mutations are associated with advanced non-small-cell lung cancer of adenocarcinoma in Asian patients. + + + + 24419411 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 9 + 0 + + + + + + + 18 + aberrantly activated AREG-EGFR signaling is required for CRTC1-MAML2-positive MEC cell growth and survival, suggesting that EGFR-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC. + + + + 23975434 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 5 + 0 + + + + + + + 18 + longer Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors use and skin rash were significant factors predictive for gefitinib antitumor activity + + + + 24965407 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 13 + 2 + 0 + + + + + + + 18 + Gene amplification is related with EGFR gene mutation in Chinese patients with non-small cell lung cancer. + + + + 22572014 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 12 + 40 + 0 + + + + + + + 18 + A prevalence of EGFR mutations in small cell lung cancer is rare, and occurs most frequently in females and nonsmokers. + + + + 24913109 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 12 + 31 + 0 + + + + + + + 18 + this is the first reported case to our knowledge of a patient with both a possible germline EGFR T790M mutation and a somatic PIK3CA mutation. + + + + 24453288 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 12 + 28 + 0 + + + + + + + 18 + Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells. + + + + 24340014 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 12 + 28 + 0 + + + + + + + 18 + Decay-accelerating factor CD55 tumor expression is a pivotal determinant of anti-EGFR-IgG3-triggered complement-mediated lysis, forcing a switch from classical complement pathway activation to C1q-dependent alternative pathway amplification. + + + + 24973443 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 12 + 15 + 0 + + + + + + + 18 + EGFR mutations were detected in 15.7 % of both the NSCLC primary tumor and lymph node metastasis and in 14.3 % of the PT only. + + + + 23212424 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 11 + 36 + 0 + + + + + + + 18 + findings suggest that SPIN90 contributes to the formation and movement of endosomal vesicles, and modulates the stability of EGFR protein, which affects cell cycle progression + + + + 24340049 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 10 + 59 + 0 + + + + + + + 18 + The GABA signaling is linked to the EGFR pathway and may work through autocrine or paracrine mechanism to promote the castration-resistant prostate cancer progression. + + + + 24296312 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 10 + 59 + 0 + + + + + + + 18 + Presence of EGFR mutations in patients with lung adenocarcinoma correlates with lower lymph node stage and a greater number of metastatic lesions in the lung and brain. + + + + 23978641 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 10 + 47 + 0 + + + + + + + 18 + our findings indicate that EGFR inhibition in GBM induces MET activation in GSCs, which is a functional requisite for GSCs activity and thus represents a promising therapeutic target. + + + + 24115218 + + + + + + + + 2014 + 9 + 20 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 20 + 10 + 6 + 0 + + + + + + + 18 + EGFR/p53 mutations were associated with lung adenocarcinomas tumor size >1 cm. EGFR mutation was a predictor of EGFR TKI response in relapsed patients. + + + + 24788590 + + + + + + + + 2014 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 13 + 12 + 41 + 0 + + + + + + + 18 + An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. + + + + 24044505 + + + + + + + + 2014 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 13 + 11 + 35 + 0 + + + + + + + 18 + EGFR high expressing cells and tumors investigated in this study are highly dependent on autophagy for growth and survival. Inhibition of autophagy may therefore provide a novel treatment opportunity for EGFR overexpressing tumors + + + + 23891088 + + + + + + + + 2014 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 13 + 11 + 22 + 0 + + + + + + + 18 + this is the first report to demonstrate that miR-566 expression is significantly increased in glioma cells and modulated the EGFR pathway through direct targeting of VHL + + + + 24650032 + + + + + + + + 2014 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 13 + 11 + 20 + 0 + + + + + + + 18 + We sought to investigate whether mucinous features, such as signet-ring cell feature and extracellular mucin, are associated with EGFR and KRAS mutations in patients with lung adenocarcinoma + + + + 25029118 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 12 + 42 + 0 + + + + + + + 18 + Loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling in prostate cancer. + + + + 24839931 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 12 + 42 + 0 + + + + + + + 18 + In this review ERBB and neuregulin signal pathway genes are associated with neuropsychiatric diseases, such as schizophrenia and bipolar disorder. + + + + 24991953 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 12 + 41 + 0 + + + + + + + 18 + Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM. + + + + 24005813 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 12 + 19 + 0 + + + + + + + 18 + Considering the current knowledge, autophagy inhibition could provide a novel strategy to enhance therapy efficacy in treatment of EGFR deregulated tumors + + + + 24335351 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 12 + 8 + 0 + + + + + + + 18 + These results suggest that EMMPRIN mediates EGFR-induced tumorigenicity and that combined targeting of EMMPRIN and EGFR may be an efficacious treatment approach. + + + + 24379084 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 11 + 44 + 0 + + + + + + + 18 + By hyperactivation of epidermal growth factor receptor (EGFR). + + + + 23912460 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 11 + 28 + 0 + + + + + + + 18 + The suppression of K-ras expression by siRNA interfered with this synergism and inhibited both EGFR and Akt activity in A549 cells. + + + + 24399305 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 11 + 4 + 0 + + + + + + + 18 + The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma. + + + + 24902879 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 11 + 2 + 0 + + + + + + + 18 + Toxoplasma gondii activates EGFR to prevent autophagy and killing of the parasite. + + + + 24367261 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 10 + 59 + 0 + + + + + + + 18 + These data reveal the distinct roles of EGFR and HER2 on expression of matrix macromolecules in cancer cells. + + + + 24792576 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 10 + 52 + 0 + + + + + + + 18 + DOK2 as a tumor suppressor in EGFR-mutant lung adenocarcinoma + + + + 24255704 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 10 + 48 + 0 + + + + + + + 18 + The regulation, function and formation of EGFR complexes. [Review] + + + + 24450637 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 10 + 48 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung adenocarcinoma. + + + + 23938291 + + + + + + + + 2014 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2014 + 9 + 6 + 10 + 17 + 0 + + + + + + + 18 + Binding of the HSV-1 envelope initiates the epidermal growth factor receptor EGFR-PI3K signaling pathway, which leads to virus-induced early cofilin phosphorylation and F-actin polymerization. + + + + 24425731 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 11 + 54 + 0 + + + + + + + 18 + Sorafenib demonstrates clinical activity in non-small cell lung cancer , especially with wild-type EGFR + + + + 24166906 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 11 + 52 + 0 + + + + + + + 18 + EGFR gene amplification and EGFR-activating mutations might not be the mechanisms leading to the constitutive activation of EGFR in triple-negative breast cancer. + + + + 22481575 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 11 + 47 + 0 + + + + + + + 18 + Induced an EGFR/IKKalpha/beta/NF-kappaB pathway. + + + + 24726344 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 11 + 33 + 0 + + + + + + + 18 + Data indicate that liver epidermal growth factor receptor (EGFR) expression is down-regulated before and during regeneration in liver steatosis. + + + + 24708244 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 52 + 0 + + + + + + + 18 + GPR101 is a critical requirement for GnRH-(1-5) transactivation of EGFR in Ishikawa cells. + + + + 24264576 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 48 + 0 + + + + + + + 18 + Data indicate epidermal growth factor receptor (EGFR)+/tumor-associated trypsinogen inhibitor (TATI)+ patients showed better survival. + + + + 24204699 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 41 + 0 + + + + + + + 18 + These results suggest that overexpression of TGF-a through induction of EGFR-MET interaction contributes to cetuximab resistance in colorectal cancer cells. + + + + 24122793 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 13 + 0 + + + + + + + 18 + Genetic polymorphisms of epidermal growth factor receptor is associated with response to 5-fluorouracil-based chemotherapy in colorectal cancer. + + + + 23800895 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 8 + 0 + + + + + + + 18 + EGFR mutation ratios in primary tumors and metastatic tumors are different in lung adenocarcinoma. + + + + 24398248 + + + + + + + + 2014 + 8 + 30 + 10 + 2 + 0 + + + + + + + + + 2014 + 8 + 30 + 10 + 5 + 0 + + + + + + + 18 + One out of every 6 tumor samples was inadequate for mutation analysis. Patients with EGFR activating mutations treated with EGFR-TKI have the longest survival. + + + + 23922984 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 11 + 50 + 0 + + + + + + + 18 + High coexpression of both EGFR and IGF1R is associated with non-small-cell lung cancer. + + + + 24210543 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 11 + 32 + 0 + + + + + + + 18 + the frequency of detected cytogenetic aberrations MYC/MYCN, EGFR and PDGRFA, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene, pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults. + + + + 25033601 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 11 + 15 + 0 + + + + + + + 18 + EGFR mutations are associated with lung adenocarcinomas. + + + + 24922693 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 10 + 54 + 0 + + + + + + + 18 + We show that Tay bridge antagonizes EGFR signalling in the Drosophila melanogaster wing disc and other tissues, and that the protein interacts with both Erk and Mkp3 + + + + 24348264 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 10 + 33 + 0 + + + + + + + 18 + Dihydrotestosterone elicits an androgen receptor-dependent acute elevation of [Ca(2+) ]i in HCPSC, most likely by activating EGF receptor signalling. + + + + 23869618 + + + + + + + + 2014 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 23 + 10 + 7 + 0 + + + + + + + 18 + Rare EGFR-mutated non-small-cell lung cancer are heterogeneous, with drug resistance of distal exon 20 insertions and better sensitivity of exon 18 or complex mutations to tyrosine kinase inhibitors. + + + + 24285021 + + + + + + + + 2014 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 16 + 12 + 33 + 0 + + + + + + + 18 + Curcumin increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells. + + + + 24512728 + + + + + + + + 2014 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 16 + 12 + 30 + 0 + + + + + + + 18 + DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway. + + + + 24647156 + + + + + + + + 2014 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 16 + 11 + 27 + 0 + + + + + + + 18 + Analysis of the A763_Y764insFQEA mutant indicates that the inserted residues shift the register of the C helix in the N-terminal direction, altering the structure in the region that is also affected by the tyrosine kinase inhibitor-sensitive EGFR-L858R. + + + + 24353160 + + + + + + + + 2014 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 16 + 10 + 14 + 0 + + + + + + + 18 + Molecular mechanisms regulating ligand-stimulated EGFR activation, internalization, and post-endocytic sorting. [Review] + + + + 24295852 + + + + + + + + 2014 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 16 + 10 + 14 + 0 + + + + + + + 18 + AUthors identify EGFR as a molecular target to overcome a novel mechanism of radioresistance in KRAS-mutant tumor cells. + + + + 24648348 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 32 + 0 + + + + + + + 18 + HLA-A*0201-restricted T cell epitopes derived from the EGFR T790M mutation have been identified and can be used for immunotherapy to reverse the EGFR T790M-mediated drug resistance. + + + + 24223798 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 24 + 0 + + + + + + + 18 + 4 genes (EGFR, ERBB2, PTK2, and RAF1) with five SNPs (rs11238349, rs17172438, rs984654, rs11773818, and rs17172432) might be pivotal factors in the development of prostate cancer. + + + + 24223781 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 24 + 0 + + + + + + + 18 + overall genomic and transcriptional landscape of lung adenocarcinoma is affected, but only to a minor extent, by EGFR and KRAS mutation status + + + + 24205279 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 17 + 0 + + + + + + + 18 + our data suggest that castPCR is highly sensitive and specific to detect EGFR mutations in non-small-cell lung cancer clinical samples. + + + + 24364033 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 17 + 0 + + + + + + + 18 + Elevated EGFR expression was associated with higher pathologic tumor stages, lymph node metastasis in esophageal squamous cell carcinoma + + + + 24131756 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 17 + 0 + + + + + + + 18 + IGF1R activation is a molecular mechanism that confers acquired resistance to erlotinib in lung cancers with the wild-type EGFR + + + + 24458568 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 14 + 0 + + + + + + + 18 + these results suggest that Ptn-induced Akt/Erk activation and some of its pleiotropic functions are mediated by EGFR trans-activation in cultured osteoblasts. + + + + 24727451 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 13 + 0 + + + + + + + 18 + High versus low EGFR expression analyzed by immunohistochemical staining in cancer cells was not significantly associated with overall survival or recurrence-free survival. + + + + 24703510 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 7 + 0 + + + + + + + 18 + patients with mutated EGFR had more lung, brain, and bone metastases, and bone metastasis was an independent negative predictor of OS. + + + + 24682604 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 12 + 4 + 0 + + + + + + + 18 + Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. + + + + 24747441 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 11 + 38 + 0 + + + + + + + 18 + Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma + + + + 24282590 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 11 + 36 + 0 + + + + + + + 18 + EGFR mutations, including in-frame deletions in exon 19 and base substitutions in exon 21 are associated with esophageal squamous cell carcinoma. + + + + 24103528 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 11 + 15 + 0 + + + + + + + 18 + Muller cells express the alpha2A-adrenergic receptor, and brimonidine triggers both Src-kinase- and matrix metalloproteinase-mediated autocrine ligand-dependent activation of epidermal growth factor receptors on Muller cells. + + + + 24781942 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 11 + 5 + 0 + + + + + + + 18 + Estimate the EGFR mutation incidence Polish non-small cell lung cancer patients. + + + + 24294366 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 11 + 3 + 0 + + + + + + + 18 + Data suggest that up-regulation of TGFA (transforming growth factor alpha)/EGFR signal transduction activates transcription factor NFkappaB resulting in up-regulation of expression of ICAM1 (intercellular adhesion molecule 1) in osteosarcoma cells. + + + + 24685520 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 10 + 44 + 0 + + + + + + + 18 + Low protein expression of p-Akt308 was associated with improved DFS and OS among patients treated with hormonal therapy following adjuvant chemotherapy. Coexpression of EGFR and p-mTOR was associated with worse OS. + + + + 24658605 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 10 + 36 + 0 + + + + + + + 18 + Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking. + + + + 24644286 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 10 + 31 + 0 + + + + + + + 18 + findings show that autochthonous EGFR-driven lung tumors inhibit antitumor immunity by activating the PD-1/PD-L1 pathway to suppress T-cell function and increase proinflammatory cytokines; these findings indicate EGFR functions as an oncogene through non-cell-autonomous mechanisms + + + + 24078774 + + + + + + + + 2014 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2014 + 8 + 9 + 10 + 11 + 0 + + + + + + + 18 + Serum CEA and CA242 levels are associated with mutations of the EGFR gene in patients with lung adenocarcinomas. + + + + 23621221 + + + + + + + + 2014 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 26 + 12 + 14 + 0 + + + + + + + 18 + study found that the frequency of EGFR mutations in lung adenocarcinomas among US Hispanics is similar to the frequency among non-Hispanic whites + + + + 23937608 + + + + + + + + 2014 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 26 + 11 + 59 + 0 + + + + + + + 18 + an EGFR mutation in exon 19 may have a role in improving survival and prognosis of lung adenocarcinoma after resection + + + + 24248816 + + + + + + + + 2014 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 26 + 11 + 20 + 0 + + + + + + + 18 + data provide evidence for AnxA2 as a mediator of EGFR endocytosis and signaling in breast cancer via regulation of cofilin activation + + + + 23792445 + + + + + + + + 2014 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 26 + 11 + 19 + 0 + + + + + + + 18 + Identify a molecular signature based on levels of pEGFR, pERBB2, and SMOX for the initiation of gastric carcinogenesis in helicobacter infected gastric epithelial cells. + + + + 24530706 + + + + + + + + 2014 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 26 + 10 + 2 + 0 + + + + + + + 18 + Report efficacy and toxicity of afatinib in the EGFR-TKI pre-treated population in routine clinical care. + + + + 24726055 + + + + + + + + 2014 + 7 + 19 + 10 + 8 + 0 + + + + + + + + + 2014 + 7 + 19 + 12 + 34 + 0 + + + + + + + 18 + EGFR mutations are higher in all types of NSCLC, 19-del and L858R are two of the more frequent mutations in Chinese patients. + + + + 24351833 + + + + + + + + 2014 + 7 + 19 + 10 + 8 + 0 + + + + + + + + + 2014 + 7 + 19 + 11 + 27 + 0 + + + + + + + 18 + MicroRNA expression profile was conducted in a cohort consisted of 128 radically resected NSCLC patients to identify EGFR mutation-related microRNAs and to determine their association with survival. + + + + 24198203 + + + + + + + + 2014 + 7 + 19 + 10 + 8 + 0 + + + + + + + + + 2014 + 7 + 19 + 10 + 11 + 0 + + + + + + + 18 + mutation is associated with improved survival time to platinum-based chemotherapy in patients with non-small-cell lung cancer + + + + 23910066 + + + + + + + + 2014 + 7 + 19 + 10 + 8 + 0 + + + + + + + + + 2014 + 7 + 19 + 10 + 11 + 0 + + + + + + + 18 + Our data suggest that a gastric cancer subtype with EGFR amplification and overexpression benefit from cetuximab treatment. + + + + 24141978 + + + + + + + + 2014 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 12 + 12 + 49 + 0 + + + + + + + 18 + Findings identify miR-27a* as a functional star sequence that exhibits novel coordinated regulation of the EGFR pathway. + + + + 23963114 + + + + + + + + 2014 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 12 + 12 + 49 + 0 + + + + + + + 18 + The rapid degradation of activated EGFR in AnxA6-depleted invasive tumor cells underlies their sensitivity to EGFR-targeted inhibitors. + + + + 24354805 + + + + + + + + 2014 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 12 + 12 + 14 + 0 + + + + + + + 18 + This study has an overall implication for establishing relevance for routine EGFR mutation diagnostics for NSCLC patients in clinics and emphasizes effectiveness for adoption of EGFR inhibitors as the first line treatment among Indian population. + + + + 24124538 + + + + + + + + 2014 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 12 + 10 + 52 + 0 + + + + + + + 18 + HPV16/18 E6 may contribute in part to EGFR mutations in lung cancer, at least in the Taiwanese population. + + + + 23797467 + + + + + + + + 2014 + 7 + 5 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 5 + 13 + 51 + 0 + + + + + + + 18 + NF-kappaB and EGFR may cooperate during intrahepatic cholangiocarcinogenesis and progression. Lymph node metastasis and EGFR positivity were associated with decreases in the survival rate. + + + + 24008372 + + + + + + + + 2014 + 7 + 5 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 5 + 12 + 48 + 0 + + + + + + + 18 + Mass spectrometry-based comparison of the phosphorylation profiles of control versus transfected cells revealed a 50-fold decrease in phosphorylation of EGFR Y974 and 1086, with no decrease in Y1173 phosphorylation. + + + + 24095926 + + + + + + + + 2014 + 7 + 5 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 5 + 12 + 6 + 0 + + + + + + + 18 + Hepatocellular carcinoma proliferation, metastasis and production of inflammatory cytokines were regulated via EGF-EGFR signal pathways. + + + + 24268047 + + + + + + + + 2014 + 7 + 5 + 10 + 1 + 0 + + + + + + + + + 2014 + 7 + 5 + 11 + 51 + 0 + + + + + + + 18 + two germline SNPs that associate with somatic mutation of the EGFR pathway + + + + 24152305 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 12 + 46 + 0 + + + + + + + 18 + using high CEA level to predict EGFR mutations seems to be more sensitive than using EGFR mutations in plasma + + + + 24459065 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 12 + 46 + 0 + + + + + + + 18 + MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells. + + + + 24083596 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 11 + 53 + 0 + + + + + + + 18 + ADCC-dependent killing of EGFR(+) A431 cancer cells. + + + + 24496456 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 11 + 50 + 0 + + + + + + + 18 + the present study did not confirm correlations between tissue mRNA levels and protein content of COX-1 and EGFR. + + + + 24171795 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 11 + 18 + 0 + + + + + + + 18 + Data show that macrophages on gastric and colorectal cancer cells migration through epidermal growth factor receptor and phosphorylation of Akt, c-Src and ERK1/2, and led to an increase of RhoA and Cdc42 activity. + + + + 23644655 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 11 + 11 + 0 + + + + + + + 18 + EGFR expression has prognostic value only for patients with metachronous metastatic CRC. + + + + 24330663 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 10 + 32 + 0 + + + + + + + 18 + In prostate cancer, EGFR mutations occur more commonly than KRAS mutations and EGFR and KRAS mutations may be mutually exclusive + + + + 24595526 + + + + + + + + 2014 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 28 + 10 + 31 + 0 + + + + + + + 18 + exonic EGFR expression particularly in exon 18 was found to be a relevant predictive biomarker for response to bevacizumab and erlotinib. + + + + 24039832 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 13 + 8 + 0 + + + + + + + 18 + In preclinical studies, the D2C7-(scdsFv)-PE38KDEL immunotoxin exhibited significant potential for treating brain tumors expressing EGFRwt, EGFRvIII, or both. + + + + 23857604 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 12 + 37 + 0 + + + + + + + 18 + the prognostic value and the oncogenic function of NOTCH3 in gliomagenesis + + + + 24143218 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 11 + 56 + 0 + + + + + + + 18 + Race was statistically significantly associated with EGFR mutational status in patients with non small cell lung cancer. + + + + 23806795 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 11 + 52 + 0 + + + + + + + 18 + EGFR/HER1 was downregulated in tumour compared to normal tissue + + + + 23991224 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 11 + 37 + 0 + + + + + + + 18 + our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180 + + + + 23728337 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 11 + 36 + 0 + + + + + + + 18 + In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling + + + + 24497843 + + + + + + + + 2014 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 21 + 10 + 17 + 0 + + + + + + + 18 + T790M mutation is the most prevalent resistance mechanism. The present study did not find any prognostic or predictive roles of T790M mutation in patients with acquired resistance to initial TKIs. + + + + 24035188 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 13 + 24 + 0 + + + + + + + 18 + Found progressive loss of PTEN and increase in EGFR, TGF-alpha, P-AKT expression from benign samples to non small cell lung cancer. Changes were correlated to differentiation extent of cancer tissue, metastasis of lymph nodes and histological classification. + + + + 24133589 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 13 + 24 + 0 + + + + + + + 18 + Tissue kallikrein facilitated the activation of EGFR, ERK1/2 and p38 cascade. Not p38 but ERK1/2 phosphorylation was severely compromised in cells depleted of EGFR. Impairment of signaling of ERK1/2 seemed not to be restricted to EGFR phosphorylation. + + + + 24530396 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 13 + 3 + 0 + + + + + + + 18 + our results could not support the combination use of intermittent erlotinib and pemetrexed in patients with EGFR mutation-negative non-squamous NSCLC. + + + + 23993733 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 32 + 0 + + + + + + + 18 + that EGFR IHC does not have value as a marker to predict erlotinib benefit in the first-line maintenance setting for advanced NSCLC + + + + 23972450 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 24 + 0 + + + + + + + 18 + EGFR overexpression is associated with the malignant transformation of oral leukoplakia. + + + + 23784518 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 3 + 0 + + + + + + + 18 + EGFR mutation is associated with response to treatment in non-small cell lung cancer. + + + + 23783797 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 3 + 0 + + + + + + + 18 + EGFR mutations are associated with lung cancer. + + + + 23817662 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 3 + 0 + + + + + + + 18 + we explored heterogeneity in expression of EGFR, VEGF and NOTCH1 in head and neck squamous cell carcinomas + + + + 23645351 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 12 + 3 + 0 + + + + + + + 18 + Overexpression of epidermal growth factor receptor is associated with rhabdomyosarcomas and drug sensitivity. + + + + 23828214 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 11 + 21 + 0 + + + + + + + 18 + Data indicate an important role for epidermal growth factor receptor (EGFR) in regulating the expression of complement components and complement activation in epidermis and keratinocytes. + + + + 24591374 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 10 + 58 + 0 + + + + + + + 18 + Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer. + + + + 23140436 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 10 + 22 + 0 + + + + + + + 18 + Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning. + + + + 24055406 + + + + + + + + 2014 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 14 + 10 + 20 + 0 + + + + + + + 18 + EGFR cytoplasm staining has no link with poorer outcome; it is even more related to better prognosis. EGFR heterogeneity of staining correlated with more aggressive tumors, and is an important marker of poor prognosis in vulvar squamous cell carcinoma. + + + + 24746196 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 12 + 22 + 0 + + + + + + + 18 + Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif. + + + + 23943881 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 12 + 22 + 0 + + + + + + + 18 + The EGF receptor (EGFR) regulator MIG6 and the apoptosis regulator BIM. + + + + 24425048 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 12 + 11 + 0 + + + + + + + 18 + In this cetuximab-treated colorectal cancer population, EGFR gain was associated with better outcome and PTEN protein expression with longer TTP in KRAS WT, KRAS WT/AREG high and KRAS/BRAF WT subpopulations. + + + + 24595598 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 11 + 27 + 0 + + + + + + + 18 + 16 tumor samples of NSCLC patients showed no mutation in any of the indicated exons of EGFR1 and k-RAS albeit significant levels of activation or expression of the above-mentined oncogenes. + + + + 24117170 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 11 + 4 + 0 + + + + + + + 18 + EGFR overexpression was associated with shortened overall survival, but not disease-free survival in head and neck squamous cell carcinoma + + + + 24234257 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 11 + 4 + 0 + + + + + + + 18 + Our results suggest that immunohistochemical analysis with mutation-specific antibodies is a promising approach for quantifying EGFR mutations, and may predict the effect of EGFR-TKI treatment for EGFR mutation-positive NSCLC. + + + + 24562619 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 10 + 26 + 0 + + + + + + + 18 + The current meta-analysis showed no evidence for significant association between EGFR 142285G > A polymorphism and breast cancer risk + + + + 24163083 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 10 + 6 + 0 + + + + + + + 18 + EGFR mutation status is highly concordant between the primary non-small cell lung cancer and corresponding brain metastases + + + + 24197981 + + + + + + + + 2014 + 6 + 7 + 10 + 1 + 0 + + + + + + + + + 2014 + 6 + 7 + 10 + 4 + 0 + + + + + + + 18 + A high frequency of somatic mutations in p53 (44.3%; 43/97) and/or EGFR (51.5%; 50/97) resulted in a high discrimination rate of tumor clonality (77.3%; 75/97) in metachronous multiple lung cancers. + + + + 24368645 + + + + + + + + 2014 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 31 + 12 + 1 + 0 + + + + + + + 18 + In this review we highlight some potential miRNAs that could be involved in the modulation of the EGF receptor pathway and consequently in Renal cell carcinoma development. + + + + 24192126 + + + + + + + + 2014 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 31 + 12 + 0 + 0 + + + + + + + 18 + This review will focus on the current (EGFR and KRAS mutations)and future biomarkers in the advanced NSCLC field and also address potential related targeted therapies for these patients. + + + + 24192124 + + + + + + + + 2014 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 31 + 12 + 0 + 0 + + + + + + + 18 + NE induces myocardial hypertrophy and up-regulates GDF-15, and this up-regulation of GDF-15 negatively regulates NE-induced myocardial hypertrophy by inhibiting EGF receptor transactivation following NE stimulation. + + + + 24554716 + + + + + + + + 2014 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 31 + 11 + 16 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are more common among females, never-smokers, and patients with adenocarcinomas of the lung and patients with exon 18 mutations have a worse survival + + + + 23749122 + + + + + + + + 2014 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 31 + 10 + 10 + 0 + + + + + + + 18 + erlotinib and cetuximab treatment was associated with SD >/= six months/PR in five of 20 patients with non-small cell lung cancer (25%), including individuals with squamous histology, TKI-resistant EGFR mutations, and wild-type EGFR + + + + 23963360 + + + + + + + + 2014 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 24 + 11 + 36 + 0 + + + + + + + 18 + this study examined whether the inhibition of glucose metabolism using 2DG enhances sensitivity to afatinib in NSCLC cells with EGFR T790M through the regulation of the AMPK/mTOR/Mcl-1 signaling pathway + + + + 23883584 + + + + + + + + 2014 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 24 + 10 + 45 + 0 + + + + + + + 18 + Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation. + + + + 24316134 + + + + + + + + 2014 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 24 + 10 + 14 + 0 + + + + + + + 18 + They further show that EGFR inhibition can promote an infiltrative invasion front composed of mesenchymal-like cells preferentially in tumors where they are abundant before therapy. + + + + 23939378 + + + + + + + + 2014 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 24 + 10 + 10 + 0 + + + + + + + 18 + Findings suggest that MET may be a therapeutic target in TNBC and that the combined therapy targeting MET and EGFR may be beneficial for the treatment of triple-negative/basal-like breast cancer (TNBC/BLBC)patients. + + + + 24615768 + + + + + + + + 2014 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 17 + 14 + 0 + 0 + + + + + + + 18 + Data suggest that epidermal growth factor receptor vIII mutant (EGFRvIII) positivity is not a major negative prognostic factor in glioblastoma patients treated according to current standards of care. + + + + 24614983 + + + + + + + + 2014 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 17 + 14 + 0 + 0 + + + + + + + 18 + SR48692 may inhibit non-small cell lung cancer cell proliferation in an EGFR-dependent mechanism. + + + + 24496038 + + + + + + + + 2014 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 17 + 11 + 21 + 0 + + + + + + + 18 + EGFR-TK inhibitors could cause keratinocytes injury, the release of IL-33 and the consequent interaction with its receptor on mast cells, that induces the secretion of several factors capable to cause skin manifestations, included IL-31 + + + + 23794184 + + + + + + + + 2014 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 10 + 10 + 21 + 0 + + + + + + + 18 + EGFR expression and Ki67 labeling index correlate with grade of meningioma [P < 0.0001 and P < 0.0001 respectively] and are statistically significant, whereas p53 expression does not correlate. + + + + 24608452 + + + + + + + + 2014 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 10 + 10 + 12 + 0 + + + + + + + 18 + A glioma classification scheme based on coexpression modules of EGFR and PDGFRA. + + + + 24550449 + + + + + + + + 2014 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 10 + 10 + 3 + 0 + + + + + + + 18 + A man with advanced adenocarcinoma who harboring exon 19 EGFR deletion and EML4-ALK gene translocation in the re-biospy specimen. + + + + 23731739 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 12 + 33 + 0 + + + + + + + 18 + Pleural effusion had a diagnostic performance for the detection of EGFR mutations in NSCLC. + + + + 23726527 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 12 + 12 + 0 + + + + + + + 18 + The association of EGFR mutation with family history of cancer also existed. + + + + 23726438 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 12 + 12 + 0 + + + + + + + 18 + EGFRvIII mutation is associated with brain tumor. + + + + 23877363 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 11 + 59 + 0 + + + + + + + 18 + Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110delta. + + + + 23877316 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 11 + 59 + 0 + + + + + + + 18 + Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy. + + + + 23951036 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 11 + 59 + 0 + + + + + + + 18 + Knock down of TSG101 causes the EGFR to accumulate in low density endosomes. + + + + 23933150 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 11 + 58 + 0 + + + + + + + 18 + the significant somatic EGFR alterations/mutations in lung adenocarcinoma (Review) + + + + 24378644 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 10 + 47 + 0 + + + + + + + 18 + High nuclear to cytoplasmic ratio of EGFR expression is specific for infiltrative glioma. + + + + 23935154 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 10 + 46 + 0 + + + + + + + 18 + Whose tumor had EGFR and ALK genetic aberration. + + + + 23683537 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 10 + 40 + 0 + + + + + + + 18 + Repeat biopsy identified pathological transformation to small cell lung cancers (SCLC) retaining the same EGFR mutation. + + + + 23683536 + + + + + + + + 2014 + 5 + 3 + 10 + 1 + 0 + + + + + + + + + 2014 + 5 + 3 + 10 + 40 + 0 + + + + + + + 18 + this study points to EGFR as a key mediator between CD9-mediated pro-MMP-9 release and cellular invasion of HT1080 cells. + + + + 24246676 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 13 + 5 + 0 + + + + + + + 18 + That block IKKalpha/beta and EGFR pathways. + + + + 23455325 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 13 + 1 + 0 + + + + + + + 18 + Data indicate that EGFR activity, which was more accurately predicted by the ratio of mitogen-inducible gene 6 (Mig6)/EGFR, highly correlated with erlotinib sensitivity in panels of cancer cell lines of different tissue origins. + + + + 23935914 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 13 + 0 + 0 + + + + + + + 18 + Aberrant EGFR signaling contributes to malignant conversion of HPV16+ head and neck squamous cell cancer cells. + + + + 23406730 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 11 + 46 + 0 + + + + + + + 18 + HER2 gene amplification and an increased EGFR gene copy number (with balanced chromosome 7 high-polysomy) were each detected in four of 28 (14.3%) salivary mucoepidermoid carcinomas. + + + + 23855785 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 11 + 40 + 0 + + + + + + + 18 + non-coding RNA transcription could be the cause and the consequence of CTCF eviction. + + + + 23929714 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 11 + 31 + 0 + + + + + + + 18 + EGFR mutation is associated with response to afatinib therapy in lung cancer + + + + 23959269 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 11 + 2 + 0 + + + + + + + 18 + EGF receptor mutated lung cancers respond better to higher doses of gefitinib and develop resistance later than when a lower dose is employed. + + + + 24033722 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 11 + 2 + 0 + + + + + + + 18 + evaluated mutations in four driver genes, epidermal growth factor receptor (EGFR), Kirsten ras oncogene (KRAS), c-MET, and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), in Chinese lung adenocarcinoma patients + + + + 23919423 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 10 + 49 + 0 + + + + + + + 18 + Data indicate that SOMAmer-based serum EGFR extracellular domain (ECD) assay accurately and specifically measures EGFR in serum. + + + + 23990977 + + + + + + + + 2014 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 26 + 10 + 41 + 0 + + + + + + + 18 + our study shows that in triple negative breast carcinomas EGFR is frequently amplified without mutation but is overexpressed + + + + 24423920 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 12 + 13 + 0 + + + + + + + 18 + The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients. + + + + 23912699 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 11 + 52 + 0 + + + + + + + 18 + The frequencies of somatic EGFR, KRAS, and ALK gene abnormalities reflect the diverse ethnicity and smoking patterns of non-small-cell lung cancers patients in the United States. + + + + 23932486 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 11 + 52 + 0 + + + + + + + 18 + A significant correlation between ERCC1 expression and EGFR mutation, and ERCC1-negative patients with exon 19 deletion had a longer progression-free survival than the other patients. + + + + 23940741 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 11 + 7 + 0 + + + + + + + 18 + EGFR mutations were found to be closely associated with the micropapillary predominant subtype. + + + + 23797772 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 10 + 44 + 0 + + + + + + + 18 + The EGFR T790M mutation was identified in 4 (17%) of 24 central nervous system lesions. + + + + 24105277 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 10 + 30 + 0 + + + + + + + 18 + The results indicate that ADAM17 mediates Ang II-induced EGFR transactivation on hepatic stellate cells, and that this process may participate in the progression of liver fibrosis + + + + 24412389 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 10 + 30 + 0 + + + + + + + 18 + Report analysis of EGFR mutations in non-small cell lung carcinomas. + + + + 24040454 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 10 + 29 + 0 + + + + + + + 18 + Results suggest a low frequency of EGFR mutations in BM-NSCLC whereas KRAS mutations are as frequent in BM-NSCLC as in primitive NSCLC. + + + + 23930206 + + + + + + + + 2014 + 4 + 19 + 10 + 2 + 0 + + + + + + + + + 2014 + 4 + 19 + 10 + 7 + 0 + + + + + + + 18 + Low miR-181a expression is associated with poor survival in patients with colorectal cancer. miR-181a expression might predict PFS in EGFR-targeted therapy. + + + + 24098024 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 11 + 28 + 0 + + + + + + + 18 + these results support a cooperation of ErbB1, ErbB4, and members of the MMP family in predicting OSCC invasion and poor clinical outcomes. + + + + 24338375 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 11 + 27 + 0 + + + + + + + 18 + Data suggest that overexpression of CK2a (casein kinase 2, alpha) in liver promotes oncogenesis by mediating EGF/EGFR- (epidermal growth factor/EGF receptor)-induced HDAC2 (histone deacetylase 2) expression in hepatocarcinogenesis. + + + + 24616922 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 11 + 21 + 0 + + + + + + + 18 + We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sorting and lysosomal degradation of the EGFR. + + + + 24344129 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 11 + 12 + 0 + + + + + + + 18 + Our results suggested that LPS increases MUC5AC expression through the TACE/TGF-alpha/EGFR pathway in HIBECs. + + + + 24027752 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 51 + 0 + + + + + + + 18 + EGFR mutation analysis by ADx-ARMS was the most sensitive compared to direct sequencing, and provided more reliable EGFR mutation assessments. + + + + 24002698 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 51 + 0 + + + + + + + 18 + Mutations and amplification in EGFR genes are minor events in small intestine adenocarcinoma. + + + + 23644682 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 43 + 0 + + + + + + + 18 + we obtained noninvasive microPET images of EGFR activity in L858R and E746-A750 del subcutaneous tumor xenografts, but not in subcutaneous tumor xenografts grown form control cell line + + + + 23956990 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 33 + 0 + + + + + + + 18 + The results obtained through routine analysis of more than 1,300 samples indicated that all types of specimen can be analyzed without any significant bias. TTF-1 immunostaining may be used to predict negative EGFR mutation status. + + + + 23934203 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 32 + 0 + + + + + + + 18 + EGFR mutation is associated with lung cancer. + + + + 24370549 + + + + + + + + 2014 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2014 + 4 + 12 + 10 + 4 + 0 + + + + + + + 18 + Wif1 methylation showed an association with unfavorable prognosis of adenocarcinoma (AC) patients with EGFR mutation. + + + + 23686431 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 13 + 48 + 0 + + + + + + + 18 + EGFR signaling in keratinocytes regulates key factors involved in skin inflammation, barrier function, and innate host defense, providing insights into the mechanisms underlying EGFRI-induced skin pathologies. + + + + 23966300 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 13 + 13 + 0 + + + + + + + 18 + results highlight the importance of EGFR signaling in maintaining skin immune homeostasis and identify a macrophage contribution to a serious adverse consequence of cancer chemotherapy + + + + 23966299 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 13 + 13 + 0 + + + + + + + 18 + Membranes and cytoplasm of the tumor cells showed variable EGFR staining intensities with a range of immunopositive cancer cells from 0% to 100% + + + + 23042483 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 13 + 3 + 0 + + + + + + + 18 + PCN-mediated oxidative stress activates the EGFR-PI3K-AKT/MEK1/2-ERK1/2 MAP kinase signaling pathway, leading to nuclear NRF2 translocation and ARE responsiveness in pulmonary epithelial cells. + + + + 24015256 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 11 + 49 + 0 + + + + + + + 18 + Our data identify a novel therapeutic approach to the treatment of FGFR3-mutant cancer, emphasizing the potential of combination approaches targeting both FGFR3 and EGFR. + + + + 23744832 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 11 + 31 + 0 + + + + + + + 18 + Major EGFR mutations and adenocarcinoma histology are independent predictors of better treatment outcome in patients with EGFR-mutant non-small cell lung cancer. + + + + 24457318 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 10 + 57 + 0 + + + + + + + 18 + EGFR mutation-specific antibodies could be an additional tool distinguishing primary versus metastatic carcinomas in the lung. + + + + 23599147 + + + + + + + + 2014 + 4 + 5 + 10 + 42 + 0 + + + + + + + + + 2014 + 4 + 5 + 10 + 46 + 0 + + + + + + + 18 + EGFR was activated in colonic macrophages in patients with ulcerative colitis. + + + + 24391216 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 11 + 22 + 0 + + + + + + + 18 + Intratumor heterogeneity of EGFR mutations correlates with the distribution of histological subtype in mixed type adenocarcinoma and is associated with smoking history. + + + + 23786997 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 11 + 21 + 0 + + + + + + + 18 + First-line afatinib significantly improves progression-free survival with a tolerable and manageable safety profile in Asian patients with EGFR mutation-positive advanced non-small cell lung cancer. + + + + 24439929 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 10 + 13 + 0 + + + + + + + 18 + Patients with a higher level of PDGFR-alpha and EGFR expression were found to have a significantly poorer prognosis than those with lower PDGFR-alpha and EGFR expression. + + + + 24510991 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 10 + 13 + 0 + + + + + + + 18 + the atmospheric electrophile, 1,2-naphthoquinone phosphorylates EGFR, thereby activating the MEK/ERK/AP-1 signal transduction pathway in A549 cells. + + + + 24067727 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 10 + 13 + 0 + + + + + + + 18 + this report have defined a novel network leading to ERK1/ERK2 activation in cysticfibrosis airway epithelial cells in response to P. aeruginosa that involves both the TPL2 and EGFR protein kinases and contributes to inflammation of CF airways. + + + + 24404585 + + + + + + + + 2014 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 29 + 10 + 8 + 0 + + + + + + + 18 + this study found an association between PTPN22 rs2476601 and EGFR rs17337023 polymorphisms and the risk of rheumatoid arthritis in a sample of Iranian population. + + + + 23350658 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 55 + 0 + + + + + + + 18 + subadditive interaction between EGFR- and AXL-targeted inhibitors across all AXL-positive TNBC cell lines may indicate that increased abundance of EGFR is principally a means to transactivation-mediated signaling. + + + + 23921085 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 44 + 0 + + + + + + + 18 + Lung adenocarcinoma patients with an EGFR T790M mutation showed a more favorable prognosis. + + + + 24369725 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 42 + 0 + + + + + + + 18 + Increase of serum EGFR is associated with acute leukemia. + + + + 23991992 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 22 + 0 + + + + + + + 18 + Tyrosine 1045 codon mutations in exon 27 of EGFR are infrequent in oral squamous cell carcinomas. + + + + 23991943 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 22 + 0 + + + + + + + 18 + EGF receptor signal pathways are activated during cyclopamine-induced radiosensitization in pancreatic cancer cells. + + + + 23903906 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 17 + 0 + + + + + + + 18 + Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. + + + + 23790025 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 11 + 5 + 0 + + + + + + + 18 + Mutation of EGFR E21 is negatively correlated with TUBB3 gene expression in non-small cell lung cancer. + + + + 24113009 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 10 + 29 + 0 + + + + + + + 18 + Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib + + + + 23729361 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 10 + 10 + 0 + + + + + + + 18 + EGFR overexpression and increase in signaling correlates with flotillin-1 expresion. + + + + 24304721 + + + + + + + + 2014 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 22 + 10 + 4 + 0 + + + + + + + 18 + Phosphorylated-FAKSer732 was barely detectable during interphase while its levels strongly increased in mitotic cells upon activation of the EGFR/MEK/ERK/CDK5 axis in an integrin-independent manner. + + + + 24091658 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 11 + 33 + 0 + + + + + + + 18 + Data indicate that the pteridin-7(8H)-one-based inhibitors targeting for both the wild-type and T790M/L858R double mutant EGFRs, as well as potent cellular antiproliferative activities. + + + + 24053674 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 11 + 33 + 0 + + + + + + + 18 + reducing EGFR activity strongly reduced pSTAT3 in vivo + + + + 23318430 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 10 + 53 + 0 + + + + + + + 18 + Report atypical teratoid/rhabdoid tumors with high levels of EGFR protein and gene amplification. + + + + 23880166 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 10 + 36 + 0 + + + + + + + 18 + Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. + + + + 23318459 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 10 + 9 + 0 + + + + + + + 18 + The effect of LAMC2 on cell growth, cell cycle, migration, invasion, and EGFR signaling in anaplastic thyroid carcinoma cells. + + + + 24170107 + + + + + + + + 2014 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 15 + 10 + 4 + 0 + + + + + + + 18 + Studies indicate that somatic mutations in EGFR result in kinase constitutive activation. + + + + 23651790 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 12 + 29 + 0 + + + + + + + 18 + The SABER method is a feasible means of determining the plasma T790M mutation status and could potentially be used to monitor EGFR-TKI therapy. + + + + 23721103 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 12 + 28 + 0 + + + + + + + 18 + EGFR gene amplification is associated with response to therapy in lung adenocarcinomas. + + + + 23525704 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 12 + 11 + 0 + + + + + + + 18 + Data suggest that detection of ductal carcinoma in situ (DCIS) based on marker expression during breast conserving surgery should be possible with a panel of molecular imaging tracers targeting CD44v6, GLUT1, HER2, IGF1-R, and EGFR. + + + + 23744486 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 59 + 0 + + + + + + + 18 + Only a small subgroup of early oral SCC is characterized by EGFR amplification, which can be identified reliably using EGFR-SISH technology. This finding suggests that EGFR gene amplification mostly occurs in advanced stages of oral SCC. + + + + 23763474 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 59 + 0 + + + + + + + 18 + G719D+L861R mutation in EGFR is associated with response to therapy in Non-Small-Cell Lung Carcinoma. + + + + 23945392 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 55 + 0 + + + + + + + 18 + EGFR mutations are associated with lung adenocarcinoma. + + + + 23945389 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 55 + 0 + + + + + + + 18 + Exon 19 and 21 mutation in EGFR is associated with response to therapy in metastatic Non-Small-Cell Lung Carcinoma. + + + + 23945384 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 55 + 0 + + + + + + + 18 + T790M mutation in EGFR is associated with response to therapy in Non-Small-Cell Lung Carcinoma. + + + + 23945382 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 11 + 55 + 0 + + + + + + + 18 + Findings support the development of CDK and Raf co-targeting strategies in EGFR/HER-2-overexpressing or RAS/RAF mutant breast cancer (BC). + + + + 23908594 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 10 + 57 + 0 + + + + + + + 18 + EGFR-mediated neoplasm resistance to tyrosine kinase inhibitors can be circumvented using interactome mapping. + + + + 24189400 + + + + + + + + 2014 + 3 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 3 + 8 + 10 + 13 + 0 + + + + + + + 18 + The prevalence of EGFR mutations was 45% with a predominance of deletion mutations in exon 19. + + + + 23771370 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 13 + 3 + 0 + + + + + + + 18 + this study suggests that combination of ATO and EGFR inhibitors is a promising therapeutic strategy against various solid tumors harboring wild-type EGFR. + + + + 23548265 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 12 + 21 + 0 + + + + + + + 18 + Ectopic expression of EGFRvA in cancer cells conferred a higher invasive capacity than EGFR in vitro and in vivo. + + + + 24240702 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 11 + 41 + 0 + + + + + + + 18 + This new discovery has highlighted the possibility that there may be a relationship between inflammation, COX-2, EGFR, and CYP19A1 in malignant mesothelioma + + + + 23729401 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 11 + 36 + 0 + + + + + + + 18 + these results suggest that coupling HDAC and HER2 inhibitory activities to an EGFR inhibitor may potentially be effective in overcoming drug resistance and preventing cancer cell migration + + + + 23536719 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 10 + 55 + 0 + + + + + + + 18 + constructed an integrated mathematical model of HER activation and trafficking. Studied HER phosphorylation and abundance data collected in a panel of human mammary epithelial cells expressing varying levels of EGFR/HER1, HER2 and HER3. + + + + 23990774 + + + + + + + + 2014 + 3 + 1 + 10 + 2 + 0 + + + + + + + + + 2014 + 3 + 1 + 10 + 9 + 0 + + + + + + + 18 + EGFR amplification is associated with response to therapy in glioblastoma. + + + + 23749785 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 13 + 4 + 0 + + + + + + + 18 + DHA not only displaced several raft-associated onco-proteins, including EGFR, Hsp90, Akt, and Src, from the rafts but also decreased total levels of those proteins via multiple pathways, including the proteasomal and lysosomal pathways + + + + 24120917 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 13 + 1 + 0 + + + + + + + 18 + High ErbB1 expression is associated with radioresistance in astrocytoma. + + + + 23595626 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 12 + 26 + 0 + + + + + + + 18 + Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-beta receptor signaling pathways contributes to renal fibrosis. + + + + 24253040 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 11 + 46 + 0 + + + + + + + 18 + Loss of CDH1 induces EGFR expression via phospho-YBX1, which is activated through the AKT signaling pathway. + + + + 24211838 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 11 + 38 + 0 + + + + + + + 18 + PML IV can interact physically with nEGFR and represses the transcription of nEGFR target genes. + + + + 23563092 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 11 + 32 + 0 + + + + + + + 18 + Increased EGFR expression is associated with cervical clear cell carcinoma. + + + + 23792604 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 11 + 28 + 0 + + + + + + + 18 + Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation. + + + + 23758840 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 10 + 56 + 0 + + + + + + + 18 + CTEN regulates EGFR protein levels through a posttranslational mechanism. + + + + 23774213 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 10 + 47 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene mutations are associated with response to therapy in non-small cell lung cancer. + + + + 23886169 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 10 + 42 + 0 + + + + + + + 18 + Our findings highlight the importance of the polybasic juxtamembrane sequence in regulating the oncogenic potential of EGFR signaling. + + + + 24142702 + + + + + + + + 2014 + 2 + 22 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 22 + 10 + 9 + 0 + + + + + + + 18 + The results demonstrated that EGF bound to EGFR more stably in the cells co-expressing EGFR and HER2, and the binding enhancement in the presence of HER2 was inhibited by either Trastuzumab or Pertuzumab + + + + 23219876 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 12 + 12 + 0 + + + + + + + 18 + Both higher EGFR positive rate and more intense EGFR expression were significantly associated with well differentiated subtype of squamous cell carcinoma + + + + 22441881 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 12 + 4 + 0 + + + + + + + 18 + The sole presence of erlotinib was capable of rapidly activate an IGF-1R-dependent, vimentin-enriched mesenchymal-like phenotype in delE746-A750-mutated epithelial cells. + + + + 23994953 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 11 + 11 + 0 + + + + + + + 18 + Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients + + + + 23590575 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 10 + 45 + 0 + + + + + + + 18 + Simultaneously blocking EGFR, IGF1R and Bcl-xl genes is capable of altering the balance between proliferating versus apoptotic and senescent cells in the favor of both of apoptosis and senescence and, therefore, the tumor cells regression. + + + + 24055032 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 10 + 39 + 0 + + + + + + + 18 + EGFRvIII and phosphorylated AKT were predictors for the patient survival and clinical outcome. + + + + 23806066 + + + + + + + + 2014 + 2 + 15 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 15 + 10 + 37 + 0 + + + + + + + 18 + malignant breast cancer cells are heterogeneous in their expression of surface-associated CD147 and that high levels of membrane CD147 correlate with cell surface EGFR and CD44 levels, activated EGFR and ERK1, and activated invadopodia. + + + + 23888049 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 12 + 25 + 0 + + + + + + + 18 + Network models inferred from the data revealed a conserved set of signaling pathways and RTK-specific features that grouped the RTKs into three distinct classes: (i) an EGFR/FGFR1/c-Met class ; (ii) an IGF-1R/NTRK2 class; and (iii) a PDGFRbeta class. + + + + 23861540 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 11 + 53 + 0 + + + + + + + 18 + an important new insight into the modulatory role of CD82 in endocytic trafficking of EGF receptor. + + + + 23897813 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 11 + 23 + 0 + + + + + + + 18 + X-ray crystal structures of the extracellular region of EGFR in complex with three inhibitory nanobodies, elucidating the modes of inhibition. + + + + 23791944 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 10 + 47 + 0 + + + + + + + 18 + Results indicate that ADAM17 is upregulated by hypoxia and contributes to hypoxia-induced cisplatin resistance via EGFR/PI3K/Akt pathway. + + + + 23625205 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 10 + 36 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene is upregulated in CRCC and associated with OPN gene expression and NF-kB signaling + + + + 22855173 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 10 + 14 + 0 + + + + + + + 18 + Report EGFR mutations in mammary analogue secretory carcinoma of salivary glands with high-grade transformation. + + + + 24145651 + + + + + + + + 2014 + 2 + 8 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 8 + 10 + 8 + 0 + + + + + + + 18 + Data indicate that coexistence of EML4-ALK fusion or ALK copy number increase and EGFR, MET, and KRAS mutations in tumor tissue from two treatment-naive Chinese non-small cell lung cancer (NSCLC) patients. + + + + 24200637 + + + + + + + + 2014 + 2 + 1 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 1 + 11 + 16 + 0 + + + + + + + 18 + A reciprocal cross-talk between intrahepatic cholangiocarcinoma cells and myofibroblasts through the HB-EGF/EGFR axis contributes to CCA progression. + + + + 23787814 + + + + + + + + 2014 + 2 + 1 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 1 + 10 + 46 + 0 + + + + + + + 18 + in a cohort of patients with lung adenocarcinomas, study found EGFR exon 20 insertions are a highly heterogeneous family of activating mutations with an incidence that is higher than previously reported + + + + 23371856 + + + + + + + + 2014 + 2 + 1 + 10 + 1 + 0 + + + + + + + + + 2014 + 2 + 1 + 10 + 32 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with response to therapy in advanced non-small-cell lung cancer. + + + + 23313171 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 12 + 19 + 0 + + + + + + + 18 + STAT1 gene expression is enhanced by nuclear EGFR. + + + + 22693070 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 12 + 0 + 0 + + + + + + + 18 + immunohistochemical EGFR expression appears to be a common feature of penile carcinomas, independently of histologic subtype, histologic grade, and human papillomavirus presence. + + + + 24075601 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 55 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with response to therapy in resected advanced non-small-cell lung cancer. + + + + 23291256 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 52 + 0 + + + + + + + 18 + Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer. + + + + 23628526 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 45 + 0 + + + + + + + 18 + EGFR activating mutations are associated with brain metastases in non-small lung cancer. + + + + 23892415 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 43 + 0 + + + + + + + 18 + Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer. + + + + 23764753 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 25 + 0 + + + + + + + 18 + Germ line epidermal growth factor receptor T790M mutations concurrent with KRAS mutations are associated with lung cancer. + + + + 23540867 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 21 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 23774386 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 11 + 10 + 0 + + + + + + + 18 + Different EGFR mutants show differential requirements for dimerization. + + + + 24063894 + + + + + + + + 2014 + 1 + 25 + 10 + 3 + 0 + + + + + + + + + 2014 + 1 + 25 + 10 + 6 + 0 + + + + + + + 18 + EGFRvIII expression can induce miR-520d-3p downregulation and the ensuing upregulation of the transcription factor E2F-1 may lead to drug resistance in hepatocellular carcinoma. + + + + 24007863 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 12 + 25 + 0 + + + + + + + 18 + correlation between EGFR mutation genotype and the radiotherapy + + + + 23514946 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 12 + 25 + 0 + + + + + + + 18 + Survival in EGFR expressing glioblastoma patients was significantly less than that in non-expressing patients. + + + + 23225805 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 12 + 7 + 0 + + + + + + + 18 + EGFRvIII upregulates the heterogeneous nuclear ribonucleoprotein (hnRNP) A1 splicing factor, promoting glycolytic gene expression and conferring significantly shorter survival in patients. + + + + 23707073 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 11 + 46 + 0 + + + + + + + 18 + A feedback loop exists between miR-21 and the EGFR signaling pathway. + + + + 24012640 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 10 + 34 + 0 + + + + + + + 18 + EGFR mutation in Uighur lung adenocarcinoma patients (16.2%) is significantly lower than that in Han lung adenocarcinoma patients (45.7%). + + + + 23425899 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 10 + 13 + 0 + + + + + + + 18 + Data indicate that AKT promotes EGFR recycling by phosphorylating and activating PIKfyve. + + + + 23757022 + + + + + + + + 2014 + 1 + 18 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 18 + 10 + 4 + 0 + + + + + + + 18 + we suggest that CM1 could be developed as a therapeutic target of lung cancer regardless of EGFR mutation status. + + + + 23232551 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 11 + 12 + 0 + + + + + + + 18 + the reduced expression of phosphor-EGFR and c-MET is chiefly responsible for all events of blocking metastasis. + + + + 23677180 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 11 + 8 + 0 + + + + + + + 18 + EGFR mutations are associated with lung cancer. + + + + 23575414 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 44 + 0 + + + + + + + 18 + EGFR mutations are associated with lung adenocarcinoma. + + + + 23575413 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 44 + 0 + + + + + + + 18 + Upregulation of EGFR expression is associated with glioma. + + + + 23076445 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 7 + 0 + + + + + + + 18 + Mutation of the EGFR gene is a positive prognostic marker in completely resected stage I non-small lung cancer + + + + 23932319 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 7 + 0 + + + + + + + 18 + Data provide evidence for the involvement of intron 1 EGFR variants and intron 24 ERBB4 variants in modulating risk for the development of in situ and invasive cervical cancer. + + + + 23927961 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 6 + 0 + + + + + + + 18 + EGFR mutation is not associated with gefitinib resistance in non-small cell lung cancer. + + + + 24222153 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 6 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small cell lung cancer. + + + + 24222150 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 6 + 0 + + + + + + + 18 + EGFR D994D polymorphism is associated with less skin toxicity in patients with colorectal cancer receiving antibody against EGFR. + + + + 24222141 + + + + + + + + 2014 + 1 + 11 + 10 + 1 + 0 + + + + + + + + + 2014 + 1 + 11 + 10 + 6 + 0 + + + + + + + 18 + a mechanism of a probiotic-derived soluble protein in modulating intestinal epithelial cell homeostasis through ADAM17-mediated HB-EGF release, leading to transactivation of EGFR. + + + + 24043629 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 13 + 17 + 0 + + + + + + + 18 + EGFR is overexpressed during a rare and novel t(7;14) translocation in multiple myeloma. + + + + 23765574 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 12 + 39 + 0 + + + + + + + 18 + The small-molecule tyrosine kinase inhibitors erlotinib and lapatinib differentially enhance the dimerization of the various ErbB receptor pairings, with the EGFR/ErbB3 heterodimer being particularly sensitive to the effects of erlotinib + + + + 24014028 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 12 + 16 + 0 + + + + + + + 18 + The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. + + + + 23222715 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 11 + 53 + 0 + + + + + + + 18 + affibody-based PET imaging of EGFR provides a promising approach for detecting Hepatocellular carcinoma in vivo. + + + + 23710458 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 11 + 42 + 0 + + + + + + + 18 + The prognostic role of FLT1/VEGFR1, heparanase and epidermal growth factor receptor gene expression in patients with resected cholangiocarcinoma, was investigated. + + + + 23704979 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 10 + 48 + 0 + + + + + + + 18 + We conclude that EGFR is upregulated in the hyperplastic alveolar epithelium in all three fibrotic forms of IIPs indicating a potential role during abnormal reepithelization + + + + 23841084 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 10 + 48 + 0 + + + + + + + 18 + we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR phosphorylation and mediates EGFR/pEGFR trafficking out of early endosomes + + + + 22859339 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 10 + 19 + 0 + + + + + + + 18 + Recognition of the presence and significance of specific EGFR mutations is important for appropriate therapeutic implementation of EGFR TKIs and research and development of mutation-specific inhibitors + + + + 23485129 + + + + + + + + 2014 + 1 + 4 + 10 + 2 + 0 + + + + + + + + + 2014 + 1 + 4 + 10 + 10 + 0 + + + + + + + 18 + Our results will add to the body of evidence, which supports that approximately 4% of anaplastic lymphoma kinase-rearranged (ALK+) tumors can have coexisting EGFR mutations. + + + + 23449277 + + + + + + + + 2013 + 12 + 28 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 28 + 12 + 16 + 0 + + + + + + + 18 + EGFR expression was significantly associated with male sex and lymph node metastasis in papillary thyroid carcinoma patients. + + + + 23569038 + + + + + + + + 2013 + 12 + 28 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 28 + 11 + 44 + 0 + + + + + + + 18 + EGFR interacts with Grb2 in both constitutive and EGF-dependent manners, whereas the HER3-Grb2 interaction requires the heteromerization of EGFR and HER3. + + + + 23700486 + + + + + + + + 2013 + 12 + 28 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 28 + 11 + 19 + 0 + + + + + + + 18 + The study confirms the high expression of the wild-type EGFR in the cutaneous squamous cell carcinoma + + + + 23986462 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 11 + 54 + 0 + + + + + + + 18 + this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. + + + + 24076656 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 11 + 23 + 0 + + + + + + + 18 + EGFR-H could be an important biomarker for aggressive papillary thyroid carcinomas, particularly in BRAF wild-type tumors. + + + + 23746767 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 11 + 19 + 0 + + + + + + + 18 + miR-219-5p inhibits receptor tyrosine kinase pathway by targeting epidermal growth factor receptor in glioblastoma. + + + + 23690991 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 11 + 19 + 0 + + + + + + + 18 + Data suggest that patients with advanced solid tumors who exhibit higher-EGFR gene copy number level show longer time to progression of tumors despite chemotherapy with nimotuzumab, monoclonal antibody to EGFR. + + + + 24046058 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 11 + 17 + 0 + + + + + + + 18 + We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation + + + + 23661635 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 10 + 48 + 0 + + + + + + + 18 + Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. + + + + 23675485 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 10 + 5 + 0 + + + + + + + 18 + This meta-analysis result suggested that EGFR or HER2 should have significant predictive ability for estimating overall survival in GC patients and may be useful for defining prognosis of GC patients. + + + + 23871709 + + + + + + + + 2013 + 12 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 21 + 10 + 5 + 0 + + + + + + + 18 + EGF, EGFRvIII, STAT3 and STAT5 have roles in progression of glioblastoma + + + + 24135280 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 12 + 34 + 0 + + + + + + + 18 + Elevated EGFR expression and gene copy number could predict poor survival in head and neck cancer patients. + + + + 24038070 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 12 + 33 + 0 + + + + + + + 18 + EGFR contains many different glycans at multiple sites and the majority of them are quite similar between membrane-bound and -secreted forms. + + + + 23371026 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 12 + 10 + 0 + + + + + + + 18 + Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng. + + + + 23668355 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 12 + 5 + 0 + + + + + + + 18 + Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3. + + + + 24082147 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 12 + 2 + 0 + + + + + + + 18 + pAkt expression significantly correlates with HER2 expression and with a poor prognosis in gastric cancer. + + + + 23236232 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 11 + 55 + 0 + + + + + + + 18 + short K63-linked polyubiquitin chains but not multimonoubiquitin provide an increased avidity for EGFR interactions with ubiquitin adaptors. + + + + 24019463 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 11 + 14 + 0 + + + + + + + 18 + Data indicate that the PTEN loss and activation of AKT signaling pathway contributed to erlotinib resistance in EGFR-mutant non-small cell lung cancer (NSCLC) cell line H1650. + + + + 23249714 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 10 + 36 + 0 + + + + + + + 18 + Data indicate that the epidermal growth factor receptor (EGFR) mutation status was not associated with disease-free survival or overall survival in resected lung adenocarcinomas. + + + + 23601297 + + + + + + + + 2013 + 12 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 12 + 14 + 10 + 5 + 0 + + + + + + + 18 + analysis of epidermal growth factor receptor internalization after activation with different ligands + + + + 23472148 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 11 + 54 + 0 + + + + + + + 18 + DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (EGFR)of which 62% are hypermethylated. + + + + 23736812 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 11 + 23 + 0 + + + + + + + 18 + Data suggest that Notch-1 might play a novel role in acquired resistance of non-small cell lung cancer to EGFR inhibitor gefitinib. + + + + 23916913 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 11 + 23 + 0 + + + + + + + 18 + data on EGFR mutation status from a large German cohort of non-small cell lung cancer patients in daily clinical practice are in agreement with data from other populations around the world with regard to associations with gender, smoking habits and TTF1 expression + + + + 24002608 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 11 + 19 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in non-small cell lung carcinoma. + + + + 23780873 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 11 + 19 + 0 + + + + + + + 18 + EGFR mutations are associated with radiotherapy response in non-small cell lung cancer patients with brain metastases. + + + + 23110940 + + + + + + + + 2013 + 12 + 7 + 10 + 4 + 0 + + + + + + + + + 2013 + 12 + 7 + 10 + 41 + 0 + + + + + + + 18 + EGFR signaling suppresses autophagy via its interaction with Beclin 1 during normal mitogenic signaling as well as during aberrant cell proliferation in cancer cells. + + + + 24034250 + + + + + + + + 2013 + 11 + 30 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 30 + 12 + 41 + 0 + + + + + + + 18 + Data suggest subpopulations of lung adenocarcinoma cells containing mutations in EGFR undergo epithelial-to-mesenchymal transition, demonstrate high levels of basal autophagy, resist protein kinase inhibitors, and thrive under hypoxic conditions. + + + + 23938604 + + + + + + + + 2013 + 11 + 30 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 30 + 12 + 2 + 0 + + + + + + + 18 + A novel, time-dependent change in the relationship between total ERK and phosphorylated ERK levels that persists without negative feedback, is reported. + + + + 23754287 + + + + + + + + 2013 + 11 + 30 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 30 + 10 + 48 + 0 + + + + + + + 18 + EGF & heregulin induced EGFR phosphorylation at Thr-669 & Ser-1046/1047. ERK-mediated Thr-669 phosphorylation suppresses constitutive tyrosine phosphosphorylation in the homo- & heterodimer asymmetric conformations. + + + + 23822636 + + + + + + + + 2013 + 11 + 30 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 30 + 10 + 37 + 0 + + + + + + + 18 + EGFR, but not ERBB2, is expressed in precursor lesions of squamous cervical neoplasia and is related to the neoplastic progression + + + + 23827764 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 12 + 14 + 0 + + + + + + + 18 + Mutation in the EGFR gene is associated with lung neoplasms + + + + 23897956 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 11 + 47 + 0 + + + + + + + 18 + Data suggest mechanisms of carcinogenesis by heavy metals involve increased activation of signaling pathways involving EGFR, PI3K/AKT (phosphatidylinositol 3-kinase/proto-oncogene protein c-AKT), and mTOR (mechanistic target of rapamycin). [REVIEW] + + + + 23297824 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 11 + 11 + 0 + + + + + + + 18 + We report that respiratory virus-induced EGFR activation suppresses endogenous airway epithelial antiviral signaling. + + + + 23999497 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 10 + 31 + 0 + + + + + + + 18 + PrP(C) over-expression enhances cell proliferation and cell cycle re-entrance after serum stimulation is due in part to the modulation of epidermal growth factor receptor (EGFR) by PrP(C) in the plasma membrane + + + + 23638794 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 10 + 29 + 0 + + + + + + + 18 + Our study revealed various EGFR expression patterns in sinonasal intestinal-type adenocarcinomas, indicating tumor heterogeneity. + + + + 23791006 + + + + + + + + 2013 + 11 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 11 + 23 + 10 + 29 + 0 + + + + + + + 18 + EGFR mutations are associated with metastatic lung adenocarcinoma. + + + + 23495083 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 12 + 27 + 0 + + + + + + + 18 + Radioiodinated PYK, one of the newly synthesized quinazoline derivatives, was found to be a desirable ligand for EGFR-TK SPECT imaging. [(125)I]PYK showed high tumor accumulation and selective EGFR-TK binding. \ + + + + 23494210 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 12 + 27 + 0 + + + + + + + 18 + inhibition of EGFR expression reduced HER2-induced anchorage-independent growth and tumorigenesis + + + + 23027125 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 12 + 7 + 0 + + + + + + + 18 + This review summarizes recent advances in tyrosine kinase inhibitors development with special focus on rational strategies for the design of potent EGFR inhibitors including molecular modeling studies based on crystallographic data. + + + + 23410174 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 12 + 3 + 0 + + + + + + + 18 + The expressions of MDR-1, RRM-1, EGFR, ERCC-1 were observed in a variety of pathological types of NSCLC. + + + + 23948418 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 54 + 0 + + + + + + + 18 + calnexin tunes the cellular responses to epidermal growth factor receptor in a manner that depends on the health status of the endoplasmic reticulum + + + + 23932718 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 52 + 0 + + + + + + + 18 + EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas. + + + + 23617883 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 51 + 0 + + + + + + + 18 + Standard cytology provides adequate material for the assessment of EGFR and Kras mutational status in non-small cell lung cancer and colorectal cancer patients. + + + + 22833420 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 49 + 0 + + + + + + + 18 + Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. + + + + 23866081 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 20 + 0 + + + + + + + 18 + For patients with lung adenocarcinoma harboring activating EGFR mutations treated with EGFR-TKIs, solid predominant subtype is a response predictor for EGFR-kinase inhibitors. + + + + 23974272 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 20 + 0 + + + + + + + 18 + activation of the MEK-ERK pathway contributed to EGFR-facilitated prostate cancer stem-like cell propagation. + + + + 23620784 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 15 + 0 + + + + + + + 18 + This study emphasizes EGFR mutation as an important predictive marker for response to oral tyrosine kinase inhibitors in the Indian population. + + + + 23620765 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 15 + 0 + + + + + + + 18 + Data indicate that TLR8 stimulation of NK-DC co-cultures significantly increased DC priming of EGFR-specific CD8(+) T cells in the presence of cetuximab. + + + + 23685782 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 11 + 12 + 0 + + + + + + + 18 + Data indicate that EGFR T790M as the most common mechanism of acquired resistance, whereas MET amplification, HER2 amplification, and small cell histologic transformation occur less frequently. + + + + 23470965 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 10 + 19 + 0 + + + + + + + 18 + Suppression of STAT3 phosphorylation with WP1193 reduced HGF expression in DeltaEGFR-expressing GBM cells. + + + + 23359207 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 10 + 7 + 0 + + + + + + + 18 + The role of miRNAs in EGFR signalling pathway is fundamental as they target key components of this pathway, and their deregulation is related to the development of a wide range of solid tumours including colorectal cancer. [Review] + + + + 23817698 + + + + + + + + 2013 + 11 + 16 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 16 + 10 + 4 + 0 + + + + + + + 18 + EGFR mutation status significantly affected the chemotherapy patterns in advanced non-small cell lung cancer . + + + + 23384673 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 12 + 15 + 0 + + + + + + + 18 + This study showed that patients with pulmonary adenocarcinoma and ILD had a lower probability of carrying tumor EGFR mutations. + + + + 23419507 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 12 + 2 + 0 + + + + + + + 18 + Data suggest that EGFR activation mediates PPARG- (peroxisome proliferator-activated receptor gamma-) induced sodium and water reabsorption via upregulation of NHE3 (sodium/hydrogen exchanger 3) and AQP1 (aquaporin 1) in proximal tubules. + + + + 23370527 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 11 + 36 + 0 + + + + + + + 18 + MET and EGFR are overexpressed in esophageal carcinosarcoma suggesting molecular targeted therapies might be an effective line of treatment. + + + + 23546020 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 11 + 36 + 0 + + + + + + + 18 + The aim of this study was to elucidate the correlation between the expression of cancer/testis antigens and clinicopathological factors, including the EGFR mutation, and to analyse the prognosis in lung adenocarcinoma. + + + + 22826471 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 11 + 14 + 0 + + + + + + + 18 + Results indicate that activation of wild-type EGFR promotes invasion and glioblastoma development independent of angiogenesis, whereas loss of its activity results in angiogenic tumor growth. + + + + 23429996 + + + + + + + + 2013 + 11 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 11 + 2 + 10 + 23 + 0 + + + + + + + 18 + we show for the first time that HGF-induced EGFR tyrosine kinase-inhibition is a very common mechanism in human cancers + + + + 23045285 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 12 + 50 + 0 + + + + + + + 18 + HER1 497K variant had significantly increased breast cancer risk. + + + + 23594562 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 12 + 40 + 0 + + + + + + + 18 + Two independent high-risk primary breast cancer subgroups for developing brain metastases were identified, represented by genetic alterations in either HER2 or EGFR/PTEN-driven pathways. + + + + 23665199 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 12 + 37 + 0 + + + + + + + 18 + EGFR expression is significantly associated with tumor staging and depth in esophageal squamous cell carcinoma. + + + + 23456637 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 11 + 48 + 0 + + + + + + + 18 + PRL-3-induced hyperactivation of EGFR correlates with increased cell growth, promigratory characteristics, and tumorigenicity in colorectal cancer. + + + + 23867504 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 11 + 6 + 0 + + + + + + + 18 + LRIG1 inhibits EGFR expression and the downstream signaling activation, interferes with Bcl-2/Topo-2 expressions and eventually sensitizes glioma cells to TMZ + + + + 23850692 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 11 + 6 + 0 + + + + + + + 18 + Data suggest that over-expression of microRNA-133a in breast cancer cells results in down-regulation of EGFR expression; this leads to suppression of phosphorylation of proto-oncogene c-Akt (p-Akt) and inhibition of p-Akt nuclear translocation. + + + + 23786162 + + + + + + + + 2013 + 10 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 10 + 26 + 10 + 59 + 0 + + + + + + + 18 + The activation of EGFR by EGF induces redistribution of surface T-cad to sites of cell-cell contact and its colocalization with phosphorylated EGFR by p38MAPK and Rac1 as key downstream signalling mediators. + + + + 23411345 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 14 + 36 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with lung carcinomas. + + + + 23408463 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 14 + 33 + 0 + + + + + + + 18 + The length of (CA)n in EGFR and (CTG)n in NOTCH4 was not associated with breast cancer (OR=0.99; 95% CI 0.59-1.37; p=0.619 and OR=1.08; 95% CI 0.71-1.65; p=0.725, respectively). + + + + 23015403 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 13 + 57 + 0 + + + + + + + 18 + The most frequent activating EGFR mutations detected in non-small setting lung cancer are absent in penile cancer + + + + 23517177 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 13 + 44 + 0 + + + + + + + 18 + In HNSCC, there are tumor responses to gefitinib without protein-altering mutations in the EGFR gene. + + + + 23548963 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 13 + 44 + 0 + + + + + + + 18 + combined silencing of EGFR and Rictor should be an effective means of treating glioblastoma + + + + 23555046 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 13 + 10 + 0 + + + + + + + 18 + EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma. + + + + 23521519 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 13 + 10 + 0 + + + + + + + 18 + Results suggest a possible participation of erbB1-4 and claudin-1 in tissue remodelling in chronic hypertrophic rhinitis. + + + + 23137868 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 12 + 39 + 0 + + + + + + + 18 + EGFR gene copy number as a potential biomarker of survival for patients with advanced colorectal cancer receiving treatment with anti-EGFR mAbs[Review] + + + + 23441167 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 12 + 28 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with lung carcinomas. + + + + 23364874 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 12 + 19 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in lung cancer. + + + + 24058967 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 11 + 15 + 0 + + + + + + + 18 + Ron synergises with EGFR to confer certain adverse features in head and neck squamous cell carcinomas. + + + + 23799848 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 11 + 7 + 0 + + + + + + + 18 + Finally, EGFR-NCE mechanistically depends on EGFR ubiquitination, as the two events can be simultaneously re-engineered on a phosphorylation/ubiquitination-incompetent EGFR backbone. + + + + 23799367 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 11 + 7 + 0 + + + + + + + 18 + EGFR expression level in gastric cancer is closely related to the incidence and development of gastric cancer, which can provide a theoretical basis for the targeted therapy for gastric cancer with EGFR as the target. + + + + 23608326 + + + + + + + + 2013 + 10 + 19 + 10 + 3 + 0 + + + + + + + + + 2013 + 10 + 19 + 10 + 4 + 0 + + + + + + + 18 + NF-kappaB pathway was critically involved in the molecular mechanisms underlying the action of EGFR and inflammatory cytokines + + + + 23707413 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 11 + 51 + 0 + + + + + + + 18 + The EGFR SNP rs2072454 was significantly associated with an increased risk of gastric cancer. + + + + 23555641 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 11 + 24 + 0 + + + + + + + 18 + Data indicate that epidermal growth factor receptor (EGFR) signaling stimulates the expression of transcription factor early growth response 2 (EGR2) to promote osteoprogenitor proliferation and survival. + + + + 23720781 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 11 + 20 + 0 + + + + + + + 18 + In this study we explored the potential of combining either erlotinib with cetuximab or trastuzumab to improve the efficacy of EGFR targeted therapy in EGFR wild-type NSCLC cell lines. + + + + 23234355 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 11 + 14 + 0 + + + + + + + 18 + acquired EGFR and KRAS mutations do not constitute the main mechanism of resistance to anti-EGFR mAb + + + + 23765179 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 10 + 41 + 0 + + + + + + + 18 + epimorphin modulates the signaling pathways mediated by EGFR for epidermal tissue organization + + + + 23219092 + + + + + + + + 2013 + 9 + 28 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 28 + 10 + 7 + 0 + + + + + + + 18 + Our findings do not provide sufficient evidence that EGFR L2 domain mutation is correlated with resistance to cetuximab in colorectal cancer + + + + 23722667 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 13 + 21 + 0 + + + + + + + 18 + Resistance to EGFR-TKI develops within less than one year in EGFR-mutated lung cancer patients. + + + + 23513863 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 13 + 15 + 0 + + + + + + + 18 + High expression of EGFR was related to poor survival of colon cancer. + + + + 23387315 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 12 + 33 + 0 + + + + + + + 18 + The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR) and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles. + + + + 23477725 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 12 + 33 + 0 + + + + + + + 18 + Results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR) signaling with Src activation and may provide a novel therapeutic target for treatment of breast cancer. + + + + 23532252 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 12 + 30 + 0 + + + + + + + 18 + IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase + + + + 23693078 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 11 + 45 + 0 + + + + + + + 18 + Our study suggests that there is a link between ALDH1 and EGFR expression in high-grade serous ovarian carcinoma + + + + 23465277 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 10 + 6 + 0 + + + + + + + 18 + Genetic variations of the A13/A14 repeat located within the EGFR 3' untranslated region have no oncogenic effect in patients with colorectal cancer. + + + + 23565769 + + + + + + + + 2013 + 9 + 21 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 21 + 10 + 6 + 0 + + + + + + + 18 + miR-7 efficiently silenced some genes involved in the epidermal growth factor receptor (EGFR) pathway and achieved favorable effects in treating glioma in vivo and in vitro + + + + 23404538 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 12 + 12 + 0 + + + + + + + 18 + EGFR mutations and ALK rearrangement is associated with resistance to EGFR tyrosine kinase inhibitors in lung cancer. + + + + 23392229 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 12 + 12 + 0 + + + + + + + 18 + Both sensitivity to EGFR-tyrosine kinase inhibitors and relative kinase activity differed among several EGFR mutations. + + + + 23387505 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 12 + 7 + 0 + + + + + + + 18 + Our results also showed that EGFR and CXCR4 are potential therapeutic targets for NSCLC and that simultaneous inhibition of EGFR and CXCR4 in NSCLC patients with concomitant expression of both CXCR4 and EGFR may be an effective treatment strategy. + + + + 23443279 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 11 + 59 + 0 + + + + + + + 18 + The interplay between EGFR and AURKA provides an explanation for the difference in EGF dependency between EGFR-WT and EGFR-mutant cells and may provide a new therapeutic strategy for lung cancer patients carrying EGFR mutations. + + + + 23520446 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 11 + 42 + 0 + + + + + + + 18 + Only 18.2% (12/66) of patients carried EGFR mutations after Neoadj-Chemo (p = 0.013). The median peak value of EGFR 19 exon mutations decreased non-significantly after Neoadj-Chemo. + + + + 23520442 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 11 + 42 + 0 + + + + + + + 18 + exon 21 EGFR mutations are associated with response to therapy in lung adenocarcinoma. + + + + 23486275 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 11 + 34 + 0 + + + + + + + 18 + EGFR mutations are associated with papillary lung tumors. + + + + 23486266 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 11 + 34 + 0 + + + + + + + 18 + EGFR is generated through proteolytic cleavage of a cell surface precursor of an alternately spliced EGF receptor isoform and that sEGFR binds to EGF with high affinity. + + + + 23731208 + + + + + + + + 2013 + 9 + 14 + 10 + 2 + 0 + + + + + + + + + 2013 + 9 + 14 + 10 + 35 + 0 + + + + + + + 18 + Whereas the wild-type EGFR catalytic domain monomer is mostly found in an inactive conformation, there is a clear shift toward the active conformation for all of the mutant EGFR kinases. + + + + 23754386 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 56 + 0 + + + + + + + 18 + our data suggest that the dual inhibition of FAK and EGFR by using plasmid vector-based RNA interference might be a novel therapeutic approach to the treatment of human non-small-cell lung cancer . + + + + 23328701 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 47 + 0 + + + + + + + 18 + A mechanism responsible for the generation of mitogenic IR-A via a novel interplay between IR and EGFR pathways in hepatocellular carcinoma. + + + + 23633480 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 45 + 0 + + + + + + + 18 + Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN). + + + + 23653350 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 44 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast cancer + + + + 23472669 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 21 + 0 + + + + + + + 18 + Overexpression of EGFR or EGFRvIII, accompanied by a loss of PTEN, contributed to the activation of multiple intracellular signalling pathways in GBM cells. + + + + 23110505 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 11 + 14 + 0 + + + + + + + 18 + Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation. + + + + 23698466 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 10 + 35 + 0 + + + + + + + 18 + Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. + + + + 22968441 + + + + + + + + 2013 + 9 + 7 + 10 + 3 + 0 + + + + + + + + + 2013 + 9 + 7 + 10 + 15 + 0 + + + + + + + 18 + Eag1 K+ channel and ErbB were expressed in all human pituitary adenomas examined while ErbB2 expression was more variable. + + + + 23413122 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 9 + 0 + + + + + + + 18 + Our study demonstrated that EGFR mutated Adenosquamous carcinoma of the lung had similar clinicopathological features as EGFR mutated adenocarcinoma + + + + 23464964 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 9 + 0 + + + + + + + 18 + In a large cancer center in Korea, the proportion of EGFR testing increased from 2007 through 2010. The high frequency of EGFR mutation positive cases warrants the need for generalized testing in Asian NSCLC patients. + + + + 23468851 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 9 + 0 + + + + + + + 18 + Exon 21 missense mutation was more frequent in lepidic predominant adenocarcinomas than in other histologic subtypes. GGO volume percentage in tumors with exon 21 missense mutation was higher than that in EGFR wild-type tumors and exon 19-mutated tumor. + + + + 23468578 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 9 + 0 + + + + + + + 18 + EGFR protein expression (any grade) and overexpression (3+) were observed in 43% and 11% of patients, respectively. + + + + 23153332 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 4 + 0 + + + + + + + 18 + EGFR mutation is associated with responsiveness to therapy in lung adenocarcinomas. + + + + 23225576 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 4 + 0 + + + + + + + 18 + EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha + + + + 23644172 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 4 + 0 + + + + + + + 18 + EGFR enhances MCM7 phosphorylation and DNA replication through Lyn phosphorylation in human cancer cells. + + + + 23764002 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 4 + 0 + + + + + + + 18 + CD44 therapy in HNSCC may target the CSC population and alter EGFR signaling + + + + 23265944 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 12 + 2 + 0 + + + + + + + 18 + Data indicate that BRAF and EGF receptor or SRC family kinase inhibition blocked proliferation and invasion of the resistant tumors. + + + + 23242808 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 11 + 24 + 0 + + + + + + + 18 + Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells. + + + + 23291982 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 11 + 14 + 0 + + + + + + + 18 + Recent evidence defines how EGF receptor is involved in tumor formation in pancreatic cancer. + + + + 23174662 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 44 + 0 + + + + + + + 18 + Report adiponectin levels in non-small lung cancer patients treated with EGFR tyrosine kinase inhibitors. + + + + 23909081 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 39 + 0 + + + + + + + 18 + Report skeletal-related events in advanced lung adenocarcinoma patients with EGFR mutations in whom bone metastasis was present. + + + + 23909080 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 39 + 0 + + + + + + + 18 + EGFR and KRAS mutational rates were comparable in primary and unpaired metastatic lung adenocarcinoma in pre-chemotherapy and postchemotherapy groups. + + + + 23337026 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 39 + 0 + + + + + + + 18 + Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. + + + + 23559009 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 16 + 0 + + + + + + + 18 + Data indicate that dual inhibition of EGFR with erlotinib and cetuximab, combined with the VEGF antibody bevacizumab, is well-tolerated, and merits further investigation. + + + + 23435217 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 14 + 0 + + + + + + + 18 + Data indicate that the concordance between EGFR and KRAS mutational status in 29 paired scraped smears and needle washing was 100%, with 7 paired samples showing the same EGFR mutation and 8 paired samples showing the same KRAS mutations. + + + + 23352033 + + + + + + + + 2013 + 8 + 31 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 31 + 10 + 13 + 0 + + + + + + + 18 + EGFR mutation was a predictor for advanced squamous cell lung cancer susceptibility to EGFR tyrosine kinase inhibitors. + + + + 22883988 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 12 + 21 + 0 + + + + + + + 18 + HAS2-dependent production of HA facilitates TGF-beta1-dependent fibroblast differentiation through promoting CD44 interaction with EGFR held within membrane-bound lipid rafts. + + + + 23589287 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 51 + 0 + + + + + + + 18 + In patients with non-small cell lung cancer, EGFR mutant content was correlated with the response and prognosis of EGFR tyrosine kinase inhibitors. + + + + 23418425 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 47 + 0 + + + + + + + 18 + miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer. + + + + 23650389 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 47 + 0 + + + + + + + 18 + We submit that the EGFR expression is not a useful prognostic element to identify patients with a major risk of meningioma recurrence + + + + 23486338 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 46 + 0 + + + + + + + 18 + EGFR amplification and rearrangement are early events in tumorigenesis and EGFRvIII follows a model of hierarchical expression. + + + + 22797070 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 23 + 0 + + + + + + + 18 + AnxA6 is a new PKCalpha scaffold to promote PKCalpha-mediated EGFR inactivation. + + + + 22797061 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 23 + 0 + + + + + + + 18 + Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. + + + + 23306155 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 20 + 0 + + + + + + + 18 + Acetylcholine increases the proliferation rate of tenocytes through mAChR stimulation and this mechanism operates via the extracellular activation of the epidermal growth factor receptor. + + + + 23212463 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 18 + 0 + + + + + + + 18 + Results suggest that the impact of irradiation on tumor cell migration depends on radiation type and cell line. + + + + 23363301 + + + + + + + + 2013 + 8 + 10 + 10 + 1 + 0 + + + + + + + + + 2013 + 8 + 10 + 11 + 17 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung cancer. + + + + 23407558 + + + + + + + + 2013 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2013 + 8 + 3 + 12 + 0 + 0 + + + + + + + 18 + A fundamental role for the dual-specificity tyrosine phosphorylation-regulated kinase, DYRK1A, in regulating EGF receptor in glioblastomas. + + + + 23635774 + + + + + + + + 2013 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2013 + 8 + 3 + 11 + 54 + 0 + + + + + + + 18 + the EGFR-R521K polymorphisms is not suitable as markers for identifying individuals with a higher risk for developing gastric cancer + + + + 23844533 + + + + + + + + 2013 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2013 + 8 + 3 + 11 + 31 + 0 + + + + + + + 18 + an EGFR mutation may have a role in nonsmall cell lung cancer presenting with miliary intrapulmonary carcinomatosis + + + + 22523351 + + + + + + + + 2013 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2013 + 8 + 3 + 11 + 9 + 0 + + + + + + + 18 + The potential mode of recognition of one of the autophosphorylation sites in the C-terminal tail, Tyr-1016, by the kinase domain revealed by X-ray crystallography. + + + + 23273428 + + + + + + + + 2013 + 8 + 3 + 10 + 2 + 0 + + + + + + + + + 2013 + 8 + 3 + 10 + 29 + 0 + + + + + + + 18 + RNAi-mediated knockdown of beta1,4GT1 increased the levels of EGFR dimerization and phosphorylation. These data suggest that cell surface beta1,4GT1 interacts with EGFR and inhibits EGFR activation + + + + 23583406 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 12 + 23 + 0 + + + + + + + 18 + collegiate smokers (former smokers who smoked between 101 lifetime cigarettes and 5 pack-years)with advanced-stage lung cancers represent a distinct subgroup of patients with a higher frequency of KRAS mutations and lower frequency of EGFR mutations compared with never smokers + + + + 23242442 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 11 + 48 + 0 + + + + + + + 18 + Our study probes the possibility that HPV infection is more frequent in patients with EGFR mutation or those who are sensitive to Erlotinib. + + + + 22627040 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 11 + 26 + 0 + + + + + + + 18 + The present study revealed that ESCC of Brazilian patients do not present mutations in hot spots of EGFR, K-RAS and BRAF and only a minor proportion present overexpression of EGFR or HER2. + + + + 23207070 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 10 + 52 + 0 + + + + + + + 18 + PKC-dependent phosphorylation of Thr654 regulates EGFR polarity in MDCK cells. + + + + 23205726 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 10 + 47 + 0 + + + + + + + 18 + EGFR mutations appear to be a rare event in Esophageal squamous cell carcinoma in high incidence areas of central Asia + + + + 23244191 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 10 + 44 + 0 + + + + + + + 18 + The status of EGFR and KRAS mutation in serum was not prognostic in patients with advanced non-small cell lung cancer + + + + 23307237 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 10 + 44 + 0 + + + + + + + 18 + There is a parallelism between an increase in EGFR expression and increase in the histopathologic grading of salivary gland mucoepidermoid carcinoma. + + + + 23361279 + + + + + + + + 2013 + 7 + 27 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 27 + 10 + 5 + 0 + + + + + + + 18 + mutation is associated with more frequent distant relapses of non-small cell lung cancer + + + + 23261144 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 12 + 20 + 0 + + + + + + + 18 + This study showed an association between vascular-poor area of primary lung adenocarcinomas and EGFR status + + + + 22492281 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 12 + 10 + 0 + + + + + + + 18 + Mutations in EGFR downstream pathways are not rare in malignant pleural mesotheliona. None of those found in this study seemed to be prognostically significant + + + + 23558893 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 11 + 58 + 0 + + + + + + + 18 + Mutations in epidermal growth factor receptor gene is associated with response to therapy in non-small-cell lung cancer. + + + + 23287850 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 11 + 53 + 0 + + + + + + + 18 + family history of cancer is higher in the EGFR mutated cohort + + + + 23273562 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 11 + 53 + 0 + + + + + + + 18 + DUOX1 plays a central role in epithelial defense responses to infection or injury, by mediating oxidative activation of Src and ADAM17 in response to ATP-dependent P2Y(2)R activation as a proximal step in EGFR transactivation and downstream signaling. + + + + 23349873 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 11 + 23 + 0 + + + + + + + 18 + EGFR exon 20 insertions is associated with non-small-cell lung cancer. + + + + 23328547 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 11 + 19 + 0 + + + + + + + 18 + EGFR gene copy number is highly heterogeneous within individual NSCLCs and this finding might well be a reason for the controversial clinical data existing regarding responsiveness to anti-EGFR therapy. + + + + 23238037 + + + + + + + + 2013 + 7 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 7 + 20 + 10 + 48 + 0 + + + + + + + 18 + Activation of epidermal growth factor receptor signaling determines the timing of centrosome separation. + + + + 23643362 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 13 + 16 + 0 + + + + + + + 18 + Lung cancer derived exosomes contain EGF receptor and can induce tolerogenic dendritic cells. + + + + 23614656 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 13 + 16 + 0 + + + + + + + 18 + It is reasonable to suggest that personalized therapy for NSCLC patients should include a genetic assessment of the EGFR mutational status for individual patients. + + + + 23423768 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 13 + 10 + 0 + + + + + + + 18 + Simultaneous expression of LAMP1 and EGFR correlates with the ovarian neoplasm grading. + + + + 23172893 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 12 + 31 + 0 + + + + + + + 18 + TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung. + + + + 22733137 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 11 + 52 + 0 + + + + + + + 18 + Results identify a link between the p14(ARF) and EGFR pathways and suggest that EGFR L858R counteracts the pro-apoptotic function of p14(ARF) by downregulating its expression to promote carcinogenesis in the lung. + + + + 22450744 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 11 + 37 + 0 + + + + + + + 18 + The prevalence of EML4-ALK, EGFR status and KRAS mutations in 208 Chinese patients with non-small cell lung cancer, is reported. + + + + 23341890 + + + + + + + + 2013 + 7 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 13 + 10 + 37 + 0 + + + + + + + 18 + EGFR are the key mediators of SDC-4 expression in MCF-7 cells. + + + + 23374155 + + + + + + + + 2013 + 7 + 6 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 6 + 11 + 18 + 0 + + + + + + + 18 + EGFR mutation is associated with breast cancer. + + + + 23317280 + + + + + + + + 2013 + 7 + 6 + 10 + 1 + 0 + + + + + + + + + 2013 + 7 + 6 + 10 + 31 + 0 + + + + + + + 18 + study anlayzed a mother and daughter with lung cancer with squamous differentiation; sequence analysis of EGFR on tumor-derived DNA revealed the copresence of 2 missense mutations in exon 18 [c.2155G>A, p.(G719S)] and in exon 20 [c.2327G>A, p.(R776H) + + + + 23358982 + + + + + + + + 2013 + 6 + 29 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 29 + 12 + 3 + 0 + + + + + + + 18 + pTyr1068 may be a predictive biomarker for screening the population for clinical response to EGFR-TKIs treatment; especially for patients with wild-type EGFR. + + + + 22901364 + + + + + + + + 2013 + 6 + 29 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 29 + 11 + 32 + 0 + + + + + + + 18 + Increased expression of wtEGFR or EGFRvIII leads to differential effects on protein expression and tyrosine phosphorylation signaling networks. + + + + 22964225 + + + + + + + + 2013 + 6 + 29 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 29 + 10 + 21 + 0 + + + + + + + 18 + The effects of EGFR on maintaining cancer stem cells are mainly mediated by AKT signaling via beta catenin. + + + + 23461856 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 12 + 10 + 0 + + + + + + + 18 + Patients with an unchanged EGFR mutational status after chemotherapy were more likely to express ERCC1, and this change may serve as a clinical indicator of therapy response + + + + 23581229 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 12 + 10 + 0 + + + + + + + 18 + The EGFR mutation research should be performed in all patients with NSCLC, giving the possibility to a considerable number of patients to perform a first line treatment with TKI (EGFR mutated patients) + + + + 23265235 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 11 + 24 + 0 + + + + + + + 18 + Xanthohumol is a potent antineoplastic chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition. + + + + 23246576 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 11 + 24 + 0 + + + + + + + 18 + Expression of EGFR is seen both in hepatocytes and biliary cells of the clusters as well as in adjacent biliary ductules in liver failure. + + + + 23114924 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 11 + 22 + 0 + + + + + + + 18 + The results of our study suggest an association between recurrence pattern and EGFR mutational status in recurrent female NSCLC patients. + + + + 23174717 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 11 + 5 + 0 + + + + + + + 18 + Results show that the cellular receptors, FAK, CD44v6, c-Met and EGFR, are biomarkers of survival and tumour progression in colorectal cancer. Increased staining for each receptor was also followed by expression elevation of at least one other marker. + + + + 22733437 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 11 + 2 + 0 + + + + + + + 18 + strong protein expression of IGF-1R and EGFR was observed in thymic carcinoma and in both thymoma and thymic carcinoma, respectively. However,IGF-1R or EGFR gene amplification was rare in thymic epithelial tumors irrespective of protein expression. + + + + 22700994 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 10 + 15 + 0 + + + + + + + 18 + the largest series of Intestinal-type sinonasal adenocarcinoma published to date, EGFR alterations were frequently observed. + + + + 23055340 + + + + + + + + 2013 + 6 + 22 + 10 + 2 + 0 + + + + + + + + + 2013 + 6 + 22 + 10 + 10 + 0 + + + + + + + 18 + positivity, but not HER2 positivity, was associated with poor patient outcomes after curative resection of stage II/III gastric cancer. + + + + 22977193 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 12 + 7 + 0 + + + + + + + 18 + EGFR mutations are not associated with tyrosine kinase inhibitors treatment efficacy in non-small cell lung cancer. + + + + 23564819 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 11 + 35 + 0 + + + + + + + 18 + EGFR mutant-lung adenocarcinoma with acquired resistance to EGFR-tyrosine kinase inhibitors responds poorly to radiotherapy for brain metastases. + + + + 23564810 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 11 + 35 + 0 + + + + + + + 18 + Patient with EGFR-mutated lung adenocarcinoma benefited with high dose pemetrexed and gefitinib chemotherapy. + + + + 23134665 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 11 + 4 + 0 + + + + + + + 18 + Newly produced four recombinant hIgG antibodies recognize 4 different sites (epitopes) in 3 different extracellular domains of EGFR and exhibit different biological effects on cancer cells. + + + + 23499740 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 10 + 58 + 0 + + + + + + + 18 + An evaluation of cytomorphologic features of advanced lung adenocarcinomas that might be associated with EGFR mutational status. + + + + 21681971 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 10 + 8 + 0 + + + + + + + 18 + We sought to study the pattern of expression of COX-2 and epidermal growth factor receptor, and their association with microvascular density, clinicopathological features, and survival in Arab Omani patients with gastric cancer. + + + + 22048943 + + + + + + + + 2013 + 6 + 15 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 15 + 10 + 8 + 0 + + + + + + + 18 + EGFR 3'UTR 774T>C polymorphism may contribute to susceptibility to bladder cancer in Chinese population. + + + + 23028094 + + + + + + + + 2013 + 6 + 8 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 8 + 12 + 58 + 0 + + + + + + + 18 + EGFR mutations were significantly identified in adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic-predominant adenocarcinoma, and papillary-predominant adenocarcinoma subtypes. + + + + 23242438 + + + + + + + + 2013 + 6 + 8 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 8 + 10 + 41 + 0 + + + + + + + 18 + Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma. + + + + 22920680 + + + + + + + + 2013 + 6 + 8 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 8 + 10 + 35 + 0 + + + + + + + 18 + EGFR, which is the product of a well-characterized oncogene in human cancers, suppresses the maturation of specific tumour-suppressor-like miRNAs in response to hypoxic stress through phosphorylation of argonaute 2 (AGO2) at Tyr 393 + + + + 23636329 + + + + + + + + 2013 + 6 + 8 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 8 + 10 + 7 + 0 + + + + + + + 18 + cell growth under hypoxic conditions led to activation of EGFR signaling and induction of EMT phenotype. + + + + 23185433 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 12 + 42 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in brain metastases of non-small cell lung carcinoma. + + + + 23086434 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 12 + 0 + 0 + + + + + + + 18 + the expression levels of EGFR, pAkt, and PTEN differ between oropharyngeal and oral cavity cancer and it may be attributed to HPV-related molecular pathogenesis + + + + 22682934 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 11 + 58 + 0 + + + + + + + 18 + Results ndicate the utility of serum DNA as a resource and pyrosequencing as a method for the detection of EGFR mutations in advanced non-small cell lung cancer (NSCLC). + + + + 23491080 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 11 + 48 + 0 + + + + + + + 18 + The triple negative phenotype in endometrial endometrioid adenocarcinoma is associated with poor prognostic surgical-pathological factors, worse prognosis and overexpression of EGFR. + + + + 23122929 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 11 + 17 + 0 + + + + + + + 18 + suggest that mutations of EGFR good markers of different aetiologies and histopathological forms of lung cancers but have little prognostic value + + + + 22267755 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 10 + 50 + 0 + + + + + + + 18 + epidermal growth factor receptor has a pathophysiologic role in pemphigus acantholysis + + + + 23404504 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 10 + 42 + 0 + + + + + + + 18 + EGFR protein expression is common in salivary gland tumors but is not associated with gene amplification, with activating mutations of EGFR being rare. + + + + 22694907 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 10 + 7 + 0 + + + + + + + 18 + The mutation rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors. + + + + 23114230 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 10 + 6 + 0 + + + + + + + 18 + Data indicate that EGFR expression level is not a clinically useful predictive biomarker in these studies. + + + + 23265711 + + + + + + + + 2013 + 6 + 1 + 10 + 1 + 0 + + + + + + + + + 2013 + 6 + 1 + 10 + 6 + 0 + + + + + + + 18 + In cortical precursor cells, EGFR sigaling activates tyrosine kinase (Trk)C and TrkB receptors. + + + + 23416450 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 12 + 6 + 0 + + + + + + + 18 + USP2a antagonizes EGFR endocytosis and thus amplifies signaling activity from the receptor. + + + + 22710717 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 44 + 0 + + + + + + + 18 + This review describes the mechanisms by which colorectal cancers gain resistance against EGFR-targeted therapies as well as strategies to bypass mutationinduced resistance in these two signaling pathways. [review] + + + + 23033949 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 41 + 0 + + + + + + + 18 + Results suggest that pAKT is activated by hypoxia in an EGFR-independent way in tumors. + + + + 23046567 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 9 + 0 + + + + + + + 18 + Inactivation of EGFR by the monoclonal antibody Cetuximab and RNA interference against STAT3 or DeltaNp63alpha. + + + + 23018838 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 9 + 0 + + + + + + + 18 + The study provides a mechanistic link between the miR-200 family and EGF/EGFR in the regulation of the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer. + + + + 22797360 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 6 + 0 + + + + + + + 18 + 3 lung adenocarcinoma patients with early venous thromboembolisms had activating mutations in EGFR, suggesting such mutations may increase thromboembolic risk. + + + + 23200589 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 3 + 0 + + + + + + + 18 + ligand induces kinase-inactive, pre-formed EGFR dimers and heterodimers to change conformation leading to kinase-active tetramers, where kinase activation occurs via an asymmetric interaction between EGFR dimers + + + + 23163584 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 11 + 2 + 0 + + + + + + + 18 + These results imply there is a functional effect of germline EGFR variants on tumor progression in glioma. + + + + 23236348 + + + + + + + + 2013 + 5 + 25 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 25 + 10 + 31 + 0 + + + + + + + 18 + Overexpression of EGFR predicted better response to neo-adjuvant chemotherapy in patients with triple negative breast cancer . + + + + 23046633 + + + + + + + + 2013 + 5 + 18 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 18 + 12 + 5 + 0 + + + + + + + 18 + The results indicated that EGFR polymorphism does not show any significant association with breast cancer. + + + + 22810499 + + + + + + + + 2013 + 5 + 18 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 18 + 11 + 6 + 0 + + + + + + + 18 + Case Report: molecular modeling of activating insertion mutation of EGFR gene in non-small cell lung cancer. + + + + 23088930 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 13 + 11 + 0 + + + + + + + 18 + EGFR and Her2 were significantly upregulated in lymph node metastasized colorectal cancer (LNM CRC) compared to non-LNM CRC. + + + + 23220854 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 12 + 18 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung cancer. + + + + 23154542 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 12 + 18 + 0 + + + + + + + 18 + These data suggested that the Pkd1 mutation induced upregulation of HDAC6 might act to slow the trafficking of EGFR + + + + 23152903 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 12 + 16 + 0 + + + + + + + 18 + data presented here demonstrate a reciprocal expression pattern between EGFR family members during keratinocyte maturation in the skin, and altered expression of EGFR and ErbB2 was identified in atopic dermatitis lesional skin as compared to healthy skin. + + + + 22552355 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 11 + 42 + 0 + + + + + + + 18 + Phospho-Akt immunoreactivity in prostate cancer shows a relationship to disease severity and outcome, Ki67 and phosphorylated EGFR expression + + + + 23133535 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 10 + 47 + 0 + + + + + + + 18 + Exon 19 EGFR mutation is associated with small-cell lung cancer with adenocarcinoma. + + + + 23154565 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 10 + 43 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small-cell lung cancer. + + + + 23154553 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 10 + 43 + 0 + + + + + + + 18 + EGFR mutation is associated with metastasis in non-small-cell lung cancer. + + + + 23154552 + + + + + + + + 2013 + 5 + 11 + 10 + 1 + 0 + + + + + + + + + 2013 + 5 + 11 + 10 + 43 + 0 + + + + + + + 18 + Cytokeratine 5/6 and EGFR expressions showed correlation so these markers are reliable to diagnose basaloid type tumors with a 5% cut-off value. + + + + 23011826 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 13 + 22 + 0 + + + + + + + 18 + Mutations affecting BRAF, EGFR, PIK3CA, and KRAS are not associated with sporadic vestibular schwannomas. + + + + 23224067 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 12 + 33 + 0 + + + + + + + 18 + Overview of the role of EGFR in glioblastoma and as a target for treatment of glioblastoma. [Review Article] + + + + 23007009 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 12 + 29 + 0 + + + + + + + 18 + EGFR was upregulated in of adrenocortical carcinoma patients, whereas EGFR expression was mostly negative in adrenocortical adenoma patients. + + + + 23302311 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 43 + 0 + + + + + + + 18 + Prognosis is worse in non-small cell lung cancer patients with KRAS mutation than that with wild type. + + + + 23302304 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 43 + 0 + + + + + + + 18 + Report improvement in the quality of molecular analysis of EGFR in non-small-cell lung cancer detected by three rounds of external quality assessment. + + + + 23378269 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 43 + 0 + + + + + + + 18 + Results suggest an alternative strategy that combines noncompetitive antibodies to achieve robust degradation of EGFR and tumor inhibition. + + + + 23319610 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 37 + 0 + + + + + + + 18 + This study developed a model to estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor. + + + + 22713695 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 35 + 0 + + + + + + + 18 + Molecular characterization of single CTCs demonstrated considerable intra- and interpatient heterogeneity of EGFR expression and genetic alterations in EGFR, KRAS, and PIK3CA + + + + 23136247 + + + + + + + + 2013 + 5 + 4 + 10 + 2 + 0 + + + + + + + + + 2013 + 5 + 4 + 11 + 34 + 0 + + + + + + + 18 + A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment. + + + + 23049743 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 12 + 7 + 0 + + + + + + + 18 + Fucoxanthin inhibited the expressions of the epidermal growth factor receptor (EGFR) and STAT3 and phosphorylated STAT3 proteins. + + + + 23118721 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 11 + 19 + 0 + + + + + + + 18 + The critical importance of a reciprocal relationship between DNA-PKcs phosphorylation and EGFR-mediated radiation response, was examined. + + + + 22923485 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 11 + 16 + 0 + + + + + + + 18 + UbcH10 expression is significantly higher in squamous cell and large cell carcinomas than in adenocarcinomas, and directly and inversely correlated with the mutational status of p53 and EGFR, respectively. + + + + 23102841 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 39 + 0 + + + + + + + 18 + data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease + + + + 23115635 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 39 + 0 + + + + + + + 18 + In patients with smoking histories up to 10 pack-years, EGFR mutation predominated over KRAS mutation. + + + + 23014527 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 37 + 0 + + + + + + + 18 + Aim of this study was to characterize further the expression of RUNX3 in lung cancers.Inactivation of RUNX3 was observed in 70% of the adenocarcinoma samples, and this was associated with promoter hypermethylation but not biased to EGFR/KRAS mutations. + + + + 22729835 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 37 + 0 + + + + + + + 18 + PIKE mediates EGFR-dependent squamous cell carcinoma proliferation. + + + + 22349826 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 33 + 0 + + + + + + + 18 + Transforming growth factor-alpha/hyaluronic acid-mediated migration and proliferation of keratinocyte requires activation of ErbB1 receptor. + + + + 23384599 + + + + + + + + 2013 + 4 + 27 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 27 + 10 + 32 + 0 + + + + + + + 18 + EGF receptor single nucleotide polymorphisms have a cumulative effect on decreasing lung adenocarcinoma risk in never-smoking women with hormone replacemtn therapy use. + + + + 23239743 + + + + + + + + 2013 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 20 + 14 + 3 + 0 + + + + + + + 18 + Dephosphorylation of AKT in association with EGFR mutation is a candidate marker for sensitivity to cetuximab in lung cancer. + + + + 22313637 + + + + + + + + 2013 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 20 + 11 + 56 + 0 + + + + + + + 18 + EGFR single nucleotide polymorphisms are associated with response to therapy in non-small-cell lung cancer. + + + + 23313300 + + + + + + + + 2013 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 20 + 10 + 29 + 0 + + + + + + + 18 + Newly developed ovarian serous adenocarcinoma cell line, TU-OS-4 overexpresses FGFR. + + + + 23274876 + + + + + + + + 2013 + 4 + 20 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 20 + 10 + 29 + 0 + + + + + + + 18 + In lung cancer, EGFR mutation occurs cumulatively by unidentified internal/external factors other than smoking. + + + + 23036155 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 12 + 0 + 0 + + + + + + + 18 + in human colon cancer cells Src-mediated cross-talk between FXR and EGFR modulates ERK phosphorylation, thereby regulating intestinal cell proliferation and tumorigenesis. + + + + 23119029 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 11 + 33 + 0 + + + + + + + 18 + These data indicate that constitutive EGFR activation promotes the aggressive invasive behavior characteristic of malignant peripheral nerve sheath tumors + + + + 23399900 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 11 + 29 + 0 + + + + + + + 18 + EGFR mutations in concert with P53 mutations accelerate cancer development and lead to evolution of therapeutic resistance + + + + 23026641 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 11 + 1 + 0 + + + + + + + 18 + Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels. + + + + 22429811 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 11 + 1 + 0 + + + + + + + 18 + our findings demonstrate that Yes and Lyn phosphorylate EGFR at Y1101, which influences EGFR nuclear translocation in this model of cetuximab resistance. + + + + 22430206 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 10 + 30 + 0 + + + + + + + 18 + Patients with concomitant IGF1R/EGFR fluorescence in situ hybridization immunohistochemistry had a worse disease-free survival and overall survival + + + + 23314677 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 10 + 29 + 0 + + + + + + + 18 + EGF receptor inhibits the Hippo pathway through activation of PI3-kinase (PI3K) and phosphoinositide-dependent kinase (PDK1), but independent of AKT activity. + + + + 23359693 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 10 + 29 + 0 + + + + + + + 18 + Studies indicate that EGFR signaling in EGFR-mutant lung cancer and hepatocyte growth factor (HGF) ligand-triggered bypass signals (HGF-Met and EGFR ligands-EGFR) must be simultaneously blocked to avoid the resistance. + + + + 22435662 + + + + + + + + 2013 + 4 + 13 + 10 + 1 + 0 + + + + + + + + + 2013 + 4 + 13 + 10 + 25 + 0 + + + + + + + 18 + EGFR copy number may be useful biomolecular marker to differentiate potentially malignant oral disorders from OSCC. EGFR was higher in nonhomogeneous leukoplakias and in advanced stages of OSCC. + + + + 22417006 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 13 + 0 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung cancer. + + + + 23059777 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 12 + 24 + 0 + + + + + + + 18 + PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation + + + + 23212918 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 12 + 21 + 0 + + + + + + + 18 + Data indicate that the invasive phenotype of MDA-MB-231 cells is mediated by phospholipase D2 (PLD2) under direct regulation of both Janus kinase 3 (JAK3) and tepidermal growth factor receptor (EGFR). + + + + 23238254 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 12 + 21 + 0 + + + + + + + 18 + CsA may promote EGFR activation via CXCL12/CXCR4 axis, and EGFR downstream ERK signaling pathway may be involved in the CsA-induced proliferation of human trophoblast cells. + + + + 22848341 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 11 + 37 + 0 + + + + + + + 18 + EGFR T790M mutation is associated with response to therapy in lung cancer. + + + + 22899358 + + + + + + + + 2013 + 4 + 6 + 10 + 2 + 0 + + + + + + + + + 2013 + 4 + 6 + 11 + 37 + 0 + + + + + + + 18 + DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC. + + + + 22732145 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 13 + 9 + 0 + + + + + + + 18 + Human bone marrow-derived mesenchymal stem cells transfected with microRNA-133a (miR-133a), which targets EGFR, were observed to express cardiac-specific markers. + + + + 23069713 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 13 + 9 + 0 + + + + + + + 18 + None of the cases was immunopositive for IDH1 and EGFR. p53 protein expression was observed in three cases with 25-30 % of cells showing weak to moderate staining. + + + + 22868530 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 13 + 4 + 0 + + + + + + + 18 + Transcriptional regulation of target genes by association with gene regulatory chromatin in cooperation with c-Myc by nuclear DeltaEGFR makes a unique contribution to its oncogenicity. + + + + 23250739 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 12 + 17 + 0 + + + + + + + 18 + Studies highlight the previously largely overlooked role of the membrane in maintaining the coupling of EGFR extracellular domains with the rest of the receptors. + + + + 23374350 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 12 + 11 + 0 + + + + + + + 18 + Study concludes that EGF binding removes steric constraints in the extracellular module, promoting activation of EGFR through N-terminal association of the transmembrane helices. + + + + 23374349 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 12 + 11 + 0 + + + + + + + 18 + results demonstrate that Rab7 CMT2B mutants impair growth factor receptor trafficking and, in turn, alter p38 and ERK1/2 signaling from perinuclear, clustered signaling endosomes + + + + 23188822 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 11 + 27 + 0 + + + + + + + 18 + Vandetanib might be effective in non small cell lung carcinoma with EGFR mutations that lack PTEN expression. + + + + 23274758 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 11 + 24 + 0 + + + + + + + 18 + A novel mechanism further defining the effect of E2/S1P on the EGFR transactivation in breast cancer cells. + + + + 23142484 + + + + + + + + 2013 + 3 + 30 + 10 + 3 + 0 + + + + + + + + + 2013 + 3 + 30 + 11 + 21 + 0 + + + + + + + 18 + a profound activation of the EGFR system in breast cancer + + + + 23089711 + + + + + + + + 2013 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 23 + 11 + 53 + 0 + + + + + + + 18 + These results suggest that flagellin regulates the residence time of EGFR on the plasma membrane and thus the signaling of EGFR through phosphorylation of Ser1047 by MAPKAPK-2. + + + + 23220022 + + + + + + + + 2013 + 3 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 23 + 11 + 8 + 0 + + + + + + + 18 + EGFR SNP-216G/T polymorphism was a potential predictor of clinical outcomes in NSCLC patients treated with EGFR-TKI. + + + + 23074112 + + + + + + + + 2013 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 16 + 12 + 25 + 0 + + + + + + + 18 + In COPD airways, aberrant EGFR activity increases PI 3-kinase/Akt-mediated phosphorylation of FoxO3A, thereby decreasing nuclear FoxO3A and increasing chemokine expression. + + + + 23099361 + + + + + + + + 2013 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 16 + 12 + 21 + 0 + + + + + + + 18 + apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma + + + + 22984561 + + + + + + + + 2013 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 16 + 11 + 10 + 0 + + + + + + + 18 + A higher expression of EGFR gene in the cytoplasm may have important effect on the progression of invasive salivary adenoid cystic carcinoma. + + + + 22781040 + + + + + + + + 2013 + 3 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 16 + 11 + 5 + 0 + + + + + + + 18 + These data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells. + + + + 22865467 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 12 + 17 + 0 + + + + + + + 18 + The low rate of K-ras and EGFR mutations, coupled with the high surface expression of EGFR, suggests similarity in the EGFR signalling pathway between Squamous cell anal carcinoma and squamous cell carcinoma of the head and neck. + + + + 23093229 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 12 + 17 + 0 + + + + + + + 18 + sex bias occurrence of hepatocellular carcinoma associated with EGFR + + + + 22899566 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 12 + 15 + 0 + + + + + + + 18 + Tissue samples burdened with specific oncogen signatures like EGFR gene amplification could be detected in precancerous lesion. This might improve follow-up and treatment protocols of glottic lesions + + + + 23397762 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 12 + 13 + 0 + + + + + + + 18 + EGFR mutations are associated with HPV presence in Japanese patients with lung cancer. + + + + 22975156 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 11 + 24 + 0 + + + + + + + 18 + Report associations between EGF and EGFR gene polymorphisms and prognosis for Chinese Han gastric cancer patients. + + + + 22534548 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 10 + 52 + 0 + + + + + + + 18 + Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination. + + + + 22833562 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 10 + 48 + 0 + + + + + + + 18 + 70 % of pulmonary adenocarcinoma female non-smoker Asian patients harbor EGFR mutations. + + + + 22707299 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 10 + 48 + 0 + + + + + + + 18 + PolyQ-htt controls EGFR degradation and recycling in fibroblasts from Huntington disease patients. + + + + 22974559 + + + + + + + + 2013 + 3 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 9 + 10 + 8 + 0 + + + + + + + 18 + findings demonstrate that WT-EGFR is a client protein of HSP90 and that their interaction is critical for maintaining both the stability of the receptor as well as the growth of EGFR-dependent cancers. + + + + 22952420 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 13 + 12 + 0 + + + + + + + 18 + The authors propose that GRP-94, EGFR, fibronectin and TSP-1 are involved in the aggregative adherence of enteroaggregative Escherichia coli-T8 to INT-407 cells. + + + + 22672426 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 12 + 30 + 0 + + + + + + + 18 + genetic association studies in a population in Republic of Korea: Data suggest that 3 SNP in EGFR (rs151904 A>T; rs162093 G>A; rs181946 C>T) are not associated with endometriosis in the population studied. + + + + 22770632 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 12 + 30 + 0 + + + + + + + 18 + this study is the first to examine the prevalence of EGFR and KRAS mutations in a South American Brazilian population. + + + + 22666783 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 12 + 23 + 0 + + + + + + + 18 + Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues. + + + + 22537942 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 11 + 45 + 0 + + + + + + + 18 + The results provide important information on how EGFR phosphorylation levels are regulated within cells. + + + + 22952062 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 11 + 40 + 0 + + + + + + + 18 + results provide a structural basis for the altered drug sensitivities caused by distinct NSCLC-associated EGFR mutations + + + + 22349823 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 58 + 0 + + + + + + + 18 + In human colorectal carcinogenesis, EGFR copy number increases progressively, from adenomas with high-grade dysplasia to locally advanced adenocarcinomas, through early invasive adenocarcinomas. + + + + 23181982 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 52 + 0 + + + + + + + 18 + Aberrations of MET are associated with EGFR and PTEN signalling and might possess relevance for targeted therapies of salivary gland carcinomas in the future. + + + + 23242174 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 52 + 0 + + + + + + + 18 + These results describe a unique role for EGFR and Met in mammary epithelial cells. + + + + 23028720 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 50 + 0 + + + + + + + 18 + a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor surface levels and EGF-induced downstream signaling. + + + + 23129763 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 50 + 0 + + + + + + + 18 + ERBB1 and ERBB2 have different roles in response to antineoplastic agents in colorectal cancer cells + + + + 23213241 + + + + + + + + 2013 + 3 + 2 + 10 + 2 + 0 + + + + + + + + + 2013 + 3 + 2 + 10 + 47 + 0 + + + + + + + 18 + In patients with lung adenocarcinoma EGFR mutations were associated with longer overall survival. + + + + 22810899 + + + + + + + + 2013 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 23 + 11 + 54 + 0 + + + + + + + 18 + EGFR gene mutation is associated with response to therapy in lung cancer + + + + 23207445 + + + + + + + + 2013 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 23 + 11 + 54 + 0 + + + + + + + 18 + Report metabolic cooperation between the EGFR/PKC-epsilon/NF-kappaB pathway in PKM2 upregulation and tumorigenesis. + + + + 23123196 + + + + + + + + 2013 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 23 + 11 + 54 + 0 + + + + + + + 18 + Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model + + + + 22952709 + + + + + + + + 2013 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 23 + 11 + 19 + 0 + + + + + + + 18 + EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways have roles in colorectal cancer and treatment [review] + + + + 23021375 + + + + + + + + 2013 + 2 + 23 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 23 + 10 + 4 + 0 + + + + + + + 18 + Nuclear localization of EGFR on activation with transforming growth factor-alpha was observed in SQ20B, but not in UMSCC47. SQ20B also had increased gammaH2AX foci compared to UMSCC47, suggesting that SQ20B has more DNA damage compared to UMSCC47. + + + + 23086695 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 12 + 6 + 0 + + + + + + + 18 + The aim of the present study was to determine the frequency of EGFR and KRAS mutations in non-small cell lung cancer in the West European Dutch population. + + + + 22528563 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 12 + 2 + 0 + + + + + + + 18 + AnxA2 has a role in EGFR-Src membrane bound signaling complex and ligand induced activation of downstream signaling pathways + + + + 22957061 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 11 + 33 + 0 + + + + + + + 18 + EGFR delE709_T710insD: a rare but potentially EGFR inhibitor responsive mutation is associated with non-small-cell lung cancer. + + + + 22982663 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 11 + 33 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small-cell lung cancer. + + + + 22982659 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 11 + 33 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small-cell lung cancer. + + + + 22982650 + + + + + + + + 2013 + 2 + 16 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 16 + 11 + 33 + 0 + + + + + + + 18 + The in-frame deletion in EGFR exon 19 is associated with polymorphisms in DNA repair and detoxification metabolism genes in never-smoking lung adenocarcinoma patients. + + + + 22573488 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 58 + 0 + + + + + + + 18 + In patients with surgically resected lung adenocarcinomas, KRAS and EGFR gene mutation status of tumors was not associated with disease-free survival. EGFR gene mutations were linked to favorable overall survival and median survival time after recurrence. + + + + 21607772 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 41 + 0 + + + + + + + 18 + Presence of membrane-bound ERalpha expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between membrane-bound ERalpha and EGFR mutation + + + + 22784503 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 38 + 0 + + + + + + + 18 + Three mutations in EGFR in endometrial cancer were identified. Two of these, were not associated with response to lapatinib or progression-free survival. One newly identified mutation was associated with partial response and progression-free survival. + + + + 22885469 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 5 + 0 + + + + + + + 18 + ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation. + + + + 22952966 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 5 + 0 + + + + + + + 18 + Data show that the EGFR is tyrosine-phosphorylated following treatment of IECs (HT-29 and IEC-6) with TNF-alpha. This requires EGFR autophosphorylation as it was blocked by the EGFR kinase inhibitor AG1478. + + + + 22988345 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 11 + 5 + 0 + + + + + + + 18 + High Expression of EGFR resulting in phosphorylated ERK and phosphorylated MEK are associated with colonic neoplasms of familial adenomatous polyposis. + + + + 21989899 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 10 + 34 + 0 + + + + + + + 18 + breast tumor kinase (Brk)/protein-tyrosine kinase 6 (PTK6), a nonreceptor protein-tyrosine kinase highly expressed in most human breast tumors, interacted with EGFR and sustained ligand-induced EGFR signaling. + + + + 22231447 + + + + + + + + 2013 + 2 + 9 + 10 + 2 + 0 + + + + + + + + + 2013 + 2 + 9 + 10 + 25 + 0 + + + + + + + 18 + results delineate a novel association of nuclear DeltaEGFR with STAT5b, which promotes oncogenesis and treatment resistance in glioblastoma by direct regulation of anti-apoptotic gene, Bcl-XL + + + + 22729867 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 11 + 58 + 0 + + + + + + + 18 + Dysregulation of epidermal growth factor receptor (EGFR) has been associated with colorectal cancer, but no evidence shows a relationship of EGFR expression to clinicopathological parameters in colorectal cancer in Taiwan. + + + + 23282210 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 11 + 57 + 0 + + + + + + + 18 + Evaluation of tumor aggressiveness in terms of EGFR responsiveness showed a reduced expression in carcinomas correlated with the increase in quantity of the mucinous component. In addition, EGFR reactivity was increased in the tumor invasion front. + + + + 22732796 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 11 + 56 + 0 + + + + + + + 18 + The current results indicated that EGFR plays more important roles in cell migration and invasion to the brain than in cell proliferation progression on 231-BR cells. + + + + 22510844 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 11 + 26 + 0 + + + + + + + 18 + EGFR exon mutation is associated with non-small-cell lung cancer. + + + + 22843317 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 10 + 53 + 0 + + + + + + + 18 + EGFR mutations is associated with response to therapy with advanced non-small-cell lung cancer. + + + + 22410386 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 10 + 24 + 0 + + + + + + + 18 + In ER-positive breast cancer, correlations were found in the expression of activated HER-receptors (pHER1, pHER2, pHER3), indicating a potential role of HER1 and HER3 in the activation of HER2. HER1 expression was not associated with prognosis. + + + + 22854050 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 10 + 19 + 0 + + + + + + + 18 + TAZ-dependent secretion of AREG indicates that activation of the EGFR signaling is an important non-cell-autonomous effector of the Hippo pathway, and TAZ as well as its targets may play significant roles in breast tumorigenesis and metastasis. + + + + 22825057 + + + + + + + + 2013 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2013 + 2 + 2 + 10 + 19 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in lung cancer. + + + + 22858585 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 44 + 0 + + + + + + + 18 + Authors suggest EGFR mutations are seen in greater frequency in mucoepidermoid carcinoma(MEC)in Asian populations, and that in these populations, EGFR mutations are seen in pulmonary but not in salivary MEC. + + + + 22871376 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 44 + 0 + + + + + + + 18 + The frequency of EGFR mutations in Lithuania patients with nonsquamous NSCLC was found to be similar to that reported in Europe. EGFR mutations were more frequent in women and never-smokers. + + + + 22836289 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 42 + 0 + + + + + + + 18 + This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed renal cell carcinoma types, whereas down-regulation of ERBB2 and LRIG1 was only present in clear cell renal cell carcinoma. + + + + 22554477 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 17 + 0 + + + + + + + 18 + Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk. + + + + 22791816 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 17 + 0 + + + + + + + 18 + Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells + + + + 22815900 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 17 + 0 + + + + + + + 18 + EGFR expression levels may determine distinct patterns of monoclonal antibodies (mABs) that contribute to the therapeutic efficacy of EGFR mAb. + + + + 23100515 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 17 + 0 + + + + + + + 18 + The combined effects of EGFR downregulation, ligand competition, and immune effector function conspire to inhibit tumor growth in xenograft models of cetuximab-resistant BRAF and KRAS mutant cancers. + + + + 22706026 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 15 + 0 + + + + + + + 18 + Aberrations of p53 and epidermal growth factor receptor genes are possibly involved in progression of esophageal basaloid squamous cell carcinoma. + + + + 22607702 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 11 + 15 + 0 + + + + + + + 18 + EGFR Exon 20 mutations are associated with response to therapy in non-small-cell lung cancer. + + + + 22895145 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 47 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small-cell lung cancer. + + + + 22895139 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 47 + 0 + + + + + + + 18 + The independent value of simultaneous membrane + cytoplasmic EGFR cell location and p53 overexpression on survival even in early stages of oral squamous cell carcinoma suggests that these markers may identify high-risk subgroups. + + + + 22417132 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 22 + 0 + + + + + + + 18 + Results provide insights into the relative energetics of intracellular and extracellular dimerization in epidermal growth factor receptor (EGFR). + + + + 22988250 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 21 + 0 + + + + + + + 18 + EGFR ligand strongly induces EGR1 and upregulates the production of growth factors and cytokines in mesenchymal stem cells. + + + + 22316125 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 19 + 0 + + + + + + + 18 + EGFR status can be determined in non-small cell lung cancer using silver-enhanced in situ hybridization. + + + + 23154768 + + + + + + + + 2013 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 26 + 10 + 19 + 0 + + + + + + + 18 + nonsmall cell lung cancers (NSCLC) harboring activating EGFR mutations were more likely to express low ERCC1 and thymidylate synthetase (TS) mRNA levels; patients with NSCLC who had ALK rearrangement were more likely to express low TS mRNA levels + + + + 22569898 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 46 + 0 + + + + + + + 18 + The endosomal recycling of the EGFR and ErbB2 receptors is associated with efficient K63-polyubiquitination, but significantly decreased Hrs tyrosine phosphorylation as well as impaired deubiquitination by AMSH. + + + + 22800866 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 45 + 0 + + + + + + + 18 + Data indicate that miR-133b can interact specifically with the 3'-UTR of epidermal growth factor receptor (EGFR) mRNA. + + + + 22883469 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 45 + 0 + + + + + + + 18 + a region in exon 19 is highly unstable in a large proportion of patients carrying EGFR deletions + + + + 22848739 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 45 + 0 + + + + + + + 18 + concentrations in colostrum/milk high on day 1 (greater than 10 ng/ml) but gradually declined by days 2, 5, and 30 + + + + 22581387 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 45 + 0 + + + + + + + 18 + endothelin A receptor and epidermal growth factor receptor signaling converge on beta-catenin to promote ovarian cancer metastasis + + + + 22480520 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 11 + 17 + 0 + + + + + + + 18 + Robust co-regulation of tyrosine phosphorylation sites has been revealed on novel protein interactions between EGFR and PDLIM1. + + + + 22851037 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 10 + 49 + 0 + + + + + + + 18 + Study indicates the efficacy of stem cells-based EGFR targeted therapy in glioblastoma multiforme (GBM). + + + + 23012408 + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + + + 2013 + 1 + 12 + 10 + 2 + 0 + + + + + + + 18 + identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR signaling + + + + 22179831 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 11 + 53 + 0 + + + + + + + 18 + Significant differences between the cell lines were found in EGFR expression but not in phosphorylation of EGFR without EGF stimulation + + + + 22773576 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 11 + 51 + 0 + + + + + + + 18 + silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling + + + + 22231449 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 11 + 12 + 0 + + + + + + + 18 + in vascular smooth muscle cells, aminoterminal fragment of urokinase induced time-dependent phosphorylation + + + + 22575880 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 10 + 56 + 0 + + + + + + + 18 + HGF regulated Src homology domain 2-containing inositol 5'-phosphatase 2 recruitment to EGFR and inhibited LPS-induced inflammation via EGFR degradation. + + + + 22936342 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 10 + 55 + 0 + + + + + + + 18 + Mechanisms for drug resistance were explored due to poor clinical response to EGFR-targeted therapy. EGFR-targeted therapy combined with other treatment modalities may bring about better progress for treating epithelial ovarian cancers. (review) + + + + 22818908 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 10 + 53 + 0 + + + + + + + 18 + Proteolytically active meprinalpha leads to an increase in EGFR and ERK1/2 phosphorylation and subsequently enhances cell proliferation and migration + + + + 22923609 + + + + + + + + 2013 + 1 + 5 + 10 + 1 + 0 + + + + + + + + + 2013 + 1 + 5 + 10 + 23 + 0 + + + + + + + 18 + data demonstrate that EGFR internalization is critical for hepatitis C virus entry and identify a hitherto-unknown association between CD81 and EGFR + + + + 22855500 + + + + + + + + 2012 + 12 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 29 + 10 + 26 + 0 + + + + + + + 18 + results suggest that oncolytic adenovirus induces autophagic cell death through an E2F1-miR-7-EGFR pathway in human cancer cells, providing a novel insight into the molecular mechanism of an anticancer virotherapy + + + + 22492316 + + + + + + + + 2012 + 12 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 29 + 10 + 2 + 0 + + + + + + + 18 + The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas. + + + + 22882865 + + + + + + + + 2012 + 12 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 29 + 10 + 2 + 0 + + + + + + + 18 + Our results, combined with previous studies, suggested an association between the EGFR gene and glioma development. + + + + 22662167 + + + + + + + + 2012 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2012 + 12 + 22 + 11 + 43 + 0 + + + + + + + 18 + Our data highlights a new functional synergism between oncogenic EGFR and PIK3CA with WNT/beta-catenin conferring high tolerance to oxidative stress generated by nutrient deprivation. + + + + 22662165 + + + + + + + + 2012 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2012 + 12 + 22 + 11 + 43 + 0 + + + + + + + 18 + The effective diffusion constant is negatively correlated with the respective dwell time for different SH2 domains and the dwell time is positively correlated with the local density of receptor tyrosine kinases phosphorylation. + + + + 22886086 + + + + + + + + 2012 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2012 + 12 + 22 + 11 + 15 + 0 + + + + + + + 18 + Overall, our results suggest that PTPs regulate multiple receptor-level phenomena via their action at the plasma membrane and cell interior and point to new possibilities for targeting PTPs for modulation of EGFR dynamics. + + + + 22824264 + + + + + + + + 2012 + 12 + 22 + 10 + 2 + 0 + + + + + + + + + 2012 + 12 + 22 + 10 + 46 + 0 + + + + + + + 18 + The expression of EGFR was associated with differentiation, clinical stage, and lymph node metastasis, but was not associated with gender, age and histological types of lung cancer. + + + + 22325225 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 27 + 0 + + + + + + + 18 + A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). + + + + 22833676 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 21 + 0 + + + + + + + 18 + Lung neoplasm patients who harbor EML4-ALK fusion genes generally have wild type EGFR and KRAS genes. + + + + 22736493 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 21 + 0 + + + + + + + 18 + Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal ke + + + + 22721997 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 21 + 0 + + + + + + + 18 + Report sssociation of rheumatoid arthritis risk with EGFR SNPs in Taiwan's Han Chinese population. + + + + 21604062 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 6 + 0 + + + + + + + 18 + EGFR mutations were present rarely in studied cohort of samples with breast cancer + + + + 22386733 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 4 + 0 + + + + + + + 18 + we found EGFR protein expression in 74% of urothelial carcinomas, but we failed to detect EGFR mutations at exons 19 to 21. + + + + 22406363 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 4 + 0 + + + + + + + 18 + In conclusion, SPRY2 is an important tumour suppressor in prostate cancer since its loss drives the PI3K/AKT pathway via functional interaction with the ErbB system. + + + + 22649008 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 11 + 0 + 0 + + + + + + + 18 + Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways. + + + + 22843679 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 59 + 0 + + + + + + + 18 + in azoospermic men decreased expression of EGFR may be responsible for decreasing GJA1 levels and increasing its cytosolic localization via the PI3K/AKT signaling pathway + + + + 22611165 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 31 + 0 + + + + + + + 18 + TBC1D16 is a GTPase activating protein for Rab4A that regulates transferrin receptor recycling and EGFR trafficking and signaling. + + + + 23019362 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 25 + 0 + + + + + + + 18 + EGFR gene mutation and gene high copy number are more common in Chinese non-small cell lung cancer patients with adenocarcinomas, advanced stage, non-smokers and females. + + + + 22340046 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 7 + 0 + + + + + + + 18 + EGFR ser1166 phosphorylation site represents a regulatory site that exerts a negative regulation on growth and proliferation of cancer cells. + + + + 22703031 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 3 + 0 + + + + + + + 18 + Interaction of E. faecalis with host cells and production of hydrogen peroxide increase EGFR activation, thereby contributing to cell proliferation. + + + + 22851748 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 2 + 0 + + + + + + + 18 + data indicate that SCD activity may control lung cancer cell metabolism, proliferation and survival by modulating the EGFR-->Akt/ERK signaling platforms + + + + 22946088 + + + + + + + + 2012 + 12 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 12 + 8 + 10 + 2 + 0 + + + + + + + 18 + Expression of the constitutively active mutant epidermal growth factor receptor is associated with significantly higher expression of interleukin-8 in human glioma specimens and glioma stem cells. + + + + 22139077 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 11 + 18 + 0 + + + + + + + 18 + a novel role of nEGFR in radioresistance, and that is, upon ionizing radiation, nEGFR inactivates the ribonuclease activity of PNPase toward c-MYC mRNA through DNAPK-mediated Ser-776 phosphorylation + + + + 22815474 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 11 + 13 + 0 + + + + + + + 18 + Using molecular dynamics simulations, study finds that the N lobe dimerization interface of the wild-type EGFR kinase domain is intrinsically disordered and that it becomes ordered only upon dimerization; some cancer-linked mutations distal to the dimerization interface, particularly the L834R mutation, facilitates EGFR dimerization by suppressing this local disorder. + + + + 22579287 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 11 + 1 + 0 + + + + + + + 18 + Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. + + + + 22810896 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 11 + 0 + 0 + + + + + + + 18 + sequencing of the EGFR TK domain, using 14 mesothelioma cell lines and 33 patient samples, did not reveal any EGFR sensitizing mutations; data show that patients with peritoneal mesothelioma do not harbor somatic mutations in the EGFR TK domain that would make them sensitive to EGFR tyrosione kinase inhibitors + + + + 22426987 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 10 + 54 + 0 + + + + + + + 18 + ligand-stimulated EGFR activated NFkappaB-dependent transcription and induced secretion of IL-6 and plasminogen activator inhibitor. + + + + 22158046 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 10 + 39 + 0 + + + + + + + 18 + in patients with nonsmall cell lung cancer, ALK gene rearrangement was significantly associated with pericardial disease and pleural disease; patients with ALK gene rearrangements and patients with EGFR mutations were predisposed to liver metastasis compared to triple negative cohort + + + + 22282022 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 10 + 14 + 0 + + + + + + + 18 + Taken together, NOK has a strong tendency towards forming aggregates, which may have physiological implications and provide the first evidence that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR. + + + + 22516751 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 10 + 14 + 0 + + + + + + + 18 + Expression of pEGFR was associated with a significantly improved overall survival in reraly breast cancer. + + + + 22562124 + + + + + + + + 2012 + 11 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 24 + 10 + 14 + 0 + + + + + + + 18 + It was shown that the main consequence of T-cad silencing in squamous cell carcinoma is facilitation of ligand-dependent EGFR activation. T-cadherin modulates the EGFR pathway activity by influencing membrane compartmentalization of EGFR. + + + + 22592160 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 32 + 0 + + + + + + + 18 + findings suggest that TIF2 is a novel binding partner for nuclear EGFR and is involved in regulating its target gene expression. + + + + 22581837 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 32 + 0 + + + + + + + 18 + NM II plays a role in the internalization of the EGFR and EGFR-mediated signaling pathways. + + + + 22718763 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 11 + 0 + + + + + + + 18 + Activation of EGFR inhibits the interaction of PCNA with CUL4A, whereas inhibition of EGFR leads to increased CUL4A-PCNA interaction and CUL4A-dependent ubiquitin-mediated degradation of PCNA + + + + 22692198 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 11 + 0 + + + + + + + 18 + EGFR mutations occur frequently in females, non-smokers and adenocarcinomas, bronchioloalveolar carcinomas, and adenosquamous carcinomas in patients with non-small cell lung cancer. The patients with EGFR mutations have better prognoses. + + + + 22321547 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + EGFR gene mutations occur more frequently in females, non-smokers and patients with adenocarcinoma. The presence of EGFR amplification appears unrelated to age, gender, histopathological types of lung cancer and subtypes of adenocarcinoma. + + + + 22321546 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + In patients with non-small cell lung cancers, EGFR gene mutation rates in males were significantly higher than in females, and higher in non-smokers than in smokers. + + + + 22321545 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + The incidence of EGFR mutations in non-small cell lung cancer is higher in Chinese patients, especially in non-smoking female patients with adenocarcinoma. + + + + 22321543 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + There is a higher EGFR mutation rate in females, pateints less than 60 years old, non-smokers, and adenocarcinoma among Chinese patients with NSCLC. + + + + 22321542 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + EGFR mutations are more frequent in female patients and patients with adenocarcinoma NSCLC, involving mainly exon 19 and 21. + + + + 22321541 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + EGFR and MGMT promoter hypermethylations are early events in the clonal evolution of gliomas and this gene inactivation has proved to be stable even in tumour recurrence. + + + + 22264301 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 11 + 10 + 0 + + + + + + + 18 + EGFR signaling is activated in human hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas. + + + + 22643351 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 47 + 0 + + + + + + + 18 + high concentration of gefitinib is not necessary to achieve long-term therapeutic effects in patients with lung adenocarcinoma harboring the EGFR mutation + + + + 23064060 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + An increase of EGFR expression during chemoradiation may be associated with significantly shorter DFS and OS. + + + + 22847519 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + Chemotherapy may reduce EGFR mutation frequency in patients with non-small cell lung carcinoma, likely the result of a preferential response of subclones with EGFR mutations in tumors with heterogeneous tumor cell populations. + + + + 22826274 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity + + + + 22799630 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + These results suggest that EGF is secreted from A549 cells by MMP and increases claudin-2 expression mediated via the activation of an EGFR/MEK/ERK pathway. + + + + 22546605 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + Results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking. + + + + 22523180 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + lung cancer patients with EGFR-mutations had longer PFS with taxane than gemcitabine when receiving a platinum-based doublet regimen. + + + + 22521649 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 24 + 0 + + + + + + + 18 + EGFR whole gene amplification is frequently observed in patients with breast cancer. + + + + 22132735 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 23 + 0 + + + + + + + 18 + Expression of EGFR was associated with late staging of gastric carcinoma. Overall 5-year survival rate was significantly higher in patients with EGFR negative expression. + + + + 21365510 + + + + + + + + 2012 + 11 + 17 + 10 + 1 + 0 + + + + + + + + + 2012 + 11 + 17 + 10 + 12 + 0 + + + + + + + 18 + Plasma EGFR mutations are associated with non-small cell lung cancer. + + + + 22610259 + + + + + + + + 2012 + 11 + 3 + 10 + 4 + 0 + + + + + + + + + 2012 + 11 + 3 + 14 + 20 + 0 + + + + + + + 18 + Hyperactive EGFR signaling through Stat3 and the Jak-Stat3 activity together promote ovarian cancer progression to cisplatin resistance + + + + 21909139 + + + + + + + + 2012 + 11 + 3 + 10 + 4 + 0 + + + + + + + + + 2012 + 11 + 3 + 13 + 31 + 0 + + + + + + + 18 + Ligation of M3R with CCh transactivated EGFR. + + + + 22511543 + + + + + + + + 2012 + 11 + 3 + 10 + 4 + 0 + + + + + + + + + 2012 + 11 + 3 + 10 + 12 + 0 + + + + + + + 18 + EGFR mutation is associated with response to treatment in adenocarcinoma of the lung. + + + + 22706608 + + + + + + + + 2012 + 11 + 3 + 10 + 4 + 0 + + + + + + + + + 2012 + 11 + 3 + 10 + 11 + 0 + + + + + + + 18 + A considerable proportion of NSCLC in Chinese patients showed discrepancy in KRAS and EGFR mutation status between primary tumors and corresponding metastases. + + + + 22177492 + + + + + + + + 2012 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 27 + 10 + 14 + 0 + + + + + + + 18 + deletion in the 3' UTR polyA tract of EGFR is a common somatic mutation that occurs in microsatellite instability-high colorectal and endometrial carcinomas + + + + 22540299 + + + + + + + + 2012 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 27 + 10 + 14 + 0 + + + + + + + 18 + Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. + + + + 22773810 + + + + + + + + 2012 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 27 + 10 + 12 + 0 + + + + + + + 18 + Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity + + + + 22553175 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 11 + 22 + 0 + + + + + + + 18 + 41 specimens (33.6%) were positive for EGFR mutation. + + + + 22677909 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 51 + 0 + + + + + + + 18 + alpha5beta1 integrin up-regulates proliferation via activation of EGFR + + + + 22626691 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 51 + 0 + + + + + + + 18 + The EGFR gene was highly mutated and mainly L858R substitutions occurred as well as insertions and deletions in lung adenocarcinomas from a Chiba Prefecture, Japan cohort. + + + + 22460425 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 51 + 0 + + + + + + + 18 + EGFR mutation rate in Korean patients with non-adenocarcinoma of the lung is relatively high and that the clinical outcomes of EGFR TKIs are modest. + + + + 22760226 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 20 + 0 + + + + + + + 18 + Epidermal growth factor receptor nonsense mutations are associated with clinical response in non-small-cell lung cancer. + + + + 22722798 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 20 + 0 + + + + + + + 18 + Results indicate that epidermal growth factor receptor (EGFR) L861Q mutation is a frequent EGFR mutation in pulmonary mucoepidermoid carcinoma (PMEC). + + + + 22526156 + + + + + + + + 2012 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 20 + 10 + 20 + 0 + + + + + + + 18 + increased activation of AXL and evidence for epithelial-to-mesenchymal transition in multiple in vitro and in vivo EGFR-mutant lung cancer models with acquired resistance to erlotinib in the absence of the EGFR p.Thr790Met alteration or MET activation + + + + 22751098 + + + + + + + + 2012 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 13 + 11 + 21 + 0 + + + + + + + 18 + Helicobacter pylori CagA activated the cellular tyrosine phosphatase, SHP-2, terminating EGFR activation and downstream signaling and increasing bacterial viability. + + + + 22704618 + + + + + + + + 2012 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 13 + 10 + 14 + 0 + + + + + + + 18 + The mutation status of both EGFR and K-Ras could be a predictive marker of response to IGF-1R TKIs. Also, MEK antagonism can abrogate primary resistance of NSCLC cells to IGF-1R TKIs. + + + + 22359227 + + + + + + + + 2012 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2012 + 10 + 13 + 10 + 10 + 0 + + + + + + + 18 + we have identified signaling events coordinated by EGFR and integrin alphavbeta5 that regulate the invasive behavior of human carcinoma cells. + + + + 22586492 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 11 + 3 + 0 + + + + + + + 18 + Results indicate that epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment is more efficient in patients with EGFR exon 19 deletion than those with EGFR L858R mutation. + + + + 22613337 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 11 + 3 + 0 + + + + + + + 18 + a tight cooperation between the EGF/EGFR and mPGES-1 leads to a significant tumorigenic gain in epithelial cells + + + + 22081067 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 10 + 50 + 0 + + + + + + + 18 + High EGFR expression and mutations in the EGFR signaling pathway are associated with treatment response in head and neck squamous cell carcinomas. + + + + 22668015 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 10 + 45 + 0 + + + + + + + 18 + non small cell lung cancer brain metastases harboring the exon 19 deletion mutation in the EGFR were smaller, more numerous and less edematous + + + + 22335887 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 10 + 41 + 0 + + + + + + + 18 + Effusion immunocytochemistry could be introduced into clinical practice to identify more NSCLC patients likely to have benefit from first-line TKI treatment, especially for those without adequate tissue for molecular-based EGFR analysis. + + + + 22525557 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 10 + 20 + 0 + + + + + + + 18 + Our results suggest the possibility that the integrated effect of functionally-related EGFR and PAR-1 genes (haplotype cluster) is associated with susceptibility to airway hyperresponsiveness. + + + + 22552271 + + + + + + + + 2012 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 29 + 10 + 20 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therapy in non-small-cell lung cancer. + + + + 22161771 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 11 + 25 + 0 + + + + + + + 18 + activation of alpha7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction + + + + 22577141 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 11 + 20 + 0 + + + + + + + 18 + High EGFR expression is associated with triple-negative breast cancer. + + + + 21264531 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 11 + 20 + 0 + + + + + + + 18 + These results suggest that glioblastomas with EGFR amplification are a heterogenous group of tumors and that behavior might differ according to the degree of amplification + + + + 22472960 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 11 + 2 + 0 + + + + + + + 18 + In patients receiving Erlotinib in combination with Gemcitabine and Capecitabine as a first-line therapy in metastatic/recurrent pancreatic cancer, EGFR expression was associated with shorter overall survival + + + + 21404106 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 10 + 34 + 0 + + + + + + + 18 + a novel mechanism of action of perifosine, directly inhibiting EGFR/MET-AKT1/3 axis, providing a rationale for a novel translational approach to the treatment of MMe. + + + + 22590625 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 10 + 24 + 0 + + + + + + + 18 + EGFR soluble isoforms and their transcripts are expressed in meningiomas. + + + + 22623992 + + + + + + + + 2012 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 22 + 10 + 22 + 0 + + + + + + + 18 + The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells. + + + + 21046231 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 11 + 22 + 0 + + + + + + + 18 + Mutation of this amino acid led to increased ERBB receptor activation and upregulation of the ERBB3/PI3K/AKT signaling pathway, which was no longer responsive to MEK inhibition + + + + 22552284 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 11 + 22 + 0 + + + + + + + 18 + by promoting EGFR internalization, reggie-1 restricts EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate adherens junction formation + + + + 22438585 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 11 + 22 + 0 + + + + + + + 18 + A transcriptional network involving the tumor suppressors Kruppel-like factor 6 and forkhead box O1 negatively regulate activated EGFR signaling in both cell culture and in vivo cancer models + + + + 22653055 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 11 + 12 + 0 + + + + + + + 18 + overexpression of wild-type as well as truncated-mutant Ankrd 13A, 13B and 13D proteins strongly inhibited rapid endocytosis of ubiquitinated EGFR from the surface in EGF-treated cells + + + + 22298428 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 10 + 44 + 0 + + + + + + + 18 + Zinc sulfate stimulation could activate the EGFR and the PI3K/Akt signaling pathway, further leading to upregulation of ICAM-1 expression in human airway epithelial cells. + + + + 19069650 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 10 + 40 + 0 + + + + + + + 18 + feedback down-regulation of LRRK1 kinase activity by EGFR plays an important role in the appropriate endosomal trafficking of EGFR + + + + 22337768 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 10 + 10 + 0 + + + + + + + 18 + EGFR was present in the parabasal layers in 27 acquired middle ear cholesteatoma cases and EGFR expression was extended to all layers of the matrix in 17 cases. There were no significant differences in age-related variances in EGFR expression. + + + + 21800041 + + + + + + + + 2012 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 15 + 10 + 6 + 0 + + + + + + + 18 + the existence of sEGFR isoforms specifically produced by NSCLC tumor cells which could represent a new potential biomarker for diagnosis and therapy of lung tumors. + + + + 22177532 + + + + + + + + 2012 + 9 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 8 + 11 + 48 + 0 + + + + + + + 18 + the protein expression of EGFR had an impact on prognosis in patients with CCRCC, while an increased copy number of chromosome 7 could be the possible reason for EGFR protein overexpression in the absence of gene amplification. + + + + 22475688 + + + + + + + + 2012 + 9 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 8 + 11 + 48 + 0 + + + + + + + 18 + High levels of EGFR phosphorylation in complete hydatidiform moles is positively correlated with aggressiveness of the disease. + + + + 22684234 + + + + + + + + 2012 + 9 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 8 + 11 + 5 + 0 + + + + + + + 18 + Studies indicate roles for enhanced EGFRtk phosphorylation and its downstream endoplasmic reticulum (ER) stress in cardiac fibrosis and microvascular endothelial dysfunction in type 1 diabetes mellitus. + + + + 22665120 + + + + + + + + 2012 + 9 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 8 + 11 + 5 + 0 + + + + + + + 18 + EGFR overexpression relates to triple negative profile (ER-/PR-/HER2-) and poor prognosis in breast cancer patients in Tunisia + + + + 22394363 + + + + + + + + 2012 + 9 + 8 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 8 + 10 + 30 + 0 + + + + + + + 18 + The identification of an in-frame splice variant of EGFR expands the mechanisms by which EGFR contributes to oncogenesis and represents the first link between two areas of cancer cell biology: EGFR signaling and the unfolded protein response. + + + + 21986942 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 11 + 23 + 0 + + + + + + + 18 + two independent head and neck squamous cell carcinoma cohorts treated with or without cetuximab, tumor EGFR levels were indicative of survival; tumor EGFR PY1068 levels provided prognostic information independent of total EGFR + + + + 22351687 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 11 + 22 + 0 + + + + + + + 18 + analysis of expression of EGFR, pAkt, NF-kappaB and MIC-1 in prostate cancer stem cells and their progenies + + + + 22384099 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 11 + 22 + 0 + + + + + + + 18 + EGFR plays critical roles in the survival, maintenance, and function of cancer stem cells + + + + 22384257 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 11 + 2 + 0 + + + + + + + 18 + first evidence provided that miR-133 may target EGFR + + + + 22407299 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 11 + 2 + 0 + + + + + + + 18 + Inhibition of survival signals and concomitant release of apoptotic potential jointly contribute to the tumor cell death following the inhibition of addicted oncogene in EGFR addicted cancers. + + + + 22194952 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 10 + 41 + 0 + + + + + + + 18 + Epidermal growth factor receptor variant III expression is associated with glioblastoma. + + + + 22492960 + + + + + + + + 2012 + 9 + 1 + 10 + 1 + 0 + + + + + + + + + 2012 + 9 + 1 + 10 + 19 + 0 + + + + + + + 18 + Overexpression of ErbB-1 and ErbB-2 was associated with poor prognostic features and decreased 5-year disease-free survival in breast cancer patients. + + + + 21104342 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 11 + 29 + 0 + + + + + + + 18 + Membrane EGFR over-expression in resected pancreatic cancer patients was associated with worse clinical outcomes + + + + 21264542 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 11 + 23 + 0 + + + + + + + 18 + C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR signaling. + + + + 22437320 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 11 + 5 + 0 + + + + + + + 18 + EGFR and nm23 can serve as reliable biomarkers for prognosis prediction in patients with nasopharyngeal carcinoma who may benefit from alternate treatment strategy and targeted treatment. + + + + 21221850 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 43 + 0 + + + + + + + 18 + Data indicate that 266 (76.2%) tumors harbored EGFR mutations, 16 (4.6%) HER2 mutations, 15 (4.3%) EML4-ALK fusions, 7 (2.0%) KRAS mutations, and 2 (0.6%) BRAF mutations. + + + + 22317764 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 41 + 0 + + + + + + + 18 + Data show that cell lines with high-level EGFR amplification/EGFRvIII expression formed highly aggressive tumors in nude mice. + + + + 22316604 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 41 + 0 + + + + + + + 18 + Both SGLT1 and EGFR overexpression in colorectal cancer was related to higher clinical stages. + + + + 21080109 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 28 + 0 + + + + + + + 18 + In breast cancer patients, early T stage, clinical response after 2 cycles, negative basal-like, negative EGFR, high Ki-67 proliferation index, and positive nm23-H1 were found to be significantly predictive of a pathological complete response. + + + + 21080107 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 28 + 0 + + + + + + + 18 + OPRM1 and EGFR were associated with variation in skin pigmentation in Indigenous Americans and Europeans for the first time. + + + + 22198722 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 20 + 0 + + + + + + + 18 + EGFR and K-ras mutations frequently occur randomly in multifocal lung adenocarcinomas + + + + 22209037 + + + + + + + + 2012 + 8 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 25 + 10 + 20 + 0 + + + + + + + 18 + Chromatin immunoprecipitation (ChIP) and promoter analysis revealed that the EGFR promoter gets occupied by transcriptionally active beta-catenin when elevated in GSK3beta-inactivated cells + + + + 22493441 + + + + + + + + 2012 + 8 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 18 + 11 + 2 + 0 + + + + + + + 18 + results indicate that downregulated Mig-6 in NSCLC tissues may serve as a new marker that can predict the activation of EGFR signaling pathway + + + + 21739478 + + + + + + + + 2012 + 8 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 18 + 10 + 48 + 0 + + + + + + + 18 + Met and EGFR to be released from lipid rafts, thus leading to their activation in a ligand-independent manner. + + + + 22032640 + + + + + + + + 2012 + 8 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 18 + 10 + 19 + 0 + + + + + + + 18 + Overexpression of Rab21 attenuated EGF-mediated mitogen-activated protein kinase (MAPK) signaling by inducing EGFR degradation. + + + + 22525675 + + + + + + + + 2012 + 8 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 18 + 10 + 3 + 0 + + + + + + + 18 + RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations. + + + + 22524660 + + + + + + + + 2012 + 8 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 18 + 10 + 3 + 0 + + + + + + + 18 + Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. + + + + 22472120 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 59 + 0 + + + + + + + 18 + Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling. + + + + 21827828 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 59 + 0 + + + + + + + 18 + that only EGFR-positive leukaemic cells respond to antibody-dependent cellular cytotoxicity of cetuximab, the monoclonal antibodies against EGFR + + + + 22674781 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 24 + 0 + + + + + + + 18 + The EGFR mutation rate in pleural metastatic tissues of lung adenocarcinoma acquired through video-assisted thoracoscopic surgery was higher compared to that in surgical resection specimens. + + + + 22134479 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 21 + 0 + + + + + + + 18 + With increasing concentration of cucurmosin, the expression of EGFR at the protein level was decreased. + + + + 22139427 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 21 + 0 + + + + + + + 18 + These results suggest a possible role of eosinophils in regulating erbB1 and thus in regulating mucosal hypertrophy in chronic hypertrophic rhinitis. + + + + 22327010 + + + + + + + + 2012 + 8 + 11 + 10 + 1 + 0 + + + + + + + + + 2012 + 8 + 11 + 10 + 21 + 0 + + + + + + + 18 + Report validity EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection. + + + + 22157931 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 43 + 0 + + + + + + + 18 + The reduced expression of E-cadherin and beta-catenin and EGFR over expression seems to be correlated with tumor differentiation and tumor progression than tumor invasion and tumor proliferation. + + + + 22281980 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 43 + 0 + + + + + + + 18 + The close relationship between EGFR and progranulin/VEGF/CD105 expression may partly play a role in high angiogenesis levels in the pN(-) TNBC subtype. + + + + 22397762 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 42 + 0 + + + + + + + 18 + EGFR somatic mutations are rare in pancreatobiliary malignancies. + + + + 22422135 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 42 + 0 + + + + + + + 18 + EGFR expression in a mutant with reduced presence of beta1,4-galactosyltransferases-I-VI was markedly reduced + + + + 22593433 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 22 + 0 + + + + + + + 18 + EGFR is highly expressed in laryngeal cancer tissue, and relates with the tissue differentiation of laryngeal cancer. + + + + 22506430 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 22 + 0 + + + + + + + 18 + Protein overexpression and/or increased gene copy number of EGFR is common in esophageal squamous cell carcinomas. + + + + 22490401 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 22 + 0 + + + + + + + 18 + Results suggest that the efficacy of anti-EGFR drugs in triple negative breast carcinomas with basal like features could be impaired by frequent alterations in the PI3K/PTEN. + + + + 22473698 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 22 + 0 + + + + + + + 18 + novel 5-alkynyl-4-anilinopyrimidines are potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases + + + + 22101132 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 11 + 18 + 0 + + + + + + + 18 + Small cell lung cancer with an epidermal growth factor receptor mutation is associated with primary gefitinib-resistant adenocarcinoma of the lung + + + + 22129360 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 10 + 24 + 0 + + + + + + + 18 + analyzed the effect of human umbilical cord blood stem cells on the inhibition of EGFR expression and EGFR signaling in glioma cells and xenografts + + + + 22348136 + + + + + + + + 2012 + 8 + 4 + 10 + 2 + 0 + + + + + + + + + 2012 + 8 + 4 + 10 + 23 + 0 + + + + + + + 18 + study has shown that EGFR exon 19 insertions are a new family of sensitizing EGFR mutations in lung adenocarcinoma + + + + 22190593 + + + + + + + + 2012 + 7 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 28 + 11 + 29 + 0 + + + + + + + 18 + Protein expression of VEGF, EGFR and MMP-9 is elevated in non-small cell lung carcinomas, correlating with progression. + + + + 22126484 + + + + + + + + 2012 + 7 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 28 + 11 + 6 + 0 + + + + + + + 18 + EGFR exon 19, 20 and 21 mutations were higher in females compared to males and higher in adenocarcinomas compared to other forms of lung cancers + + + + 22430133 + + + + + + + + 2012 + 7 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 28 + 11 + 5 + 0 + + + + + + + 18 + Data indicate that TaqMan(R) Mutation Detection assay is an important technology to consider in the field of mutation detection for KRAS, BRAF and EGFR point mutation screening. + + + + 22426079 + + + + + + + + 2012 + 7 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 28 + 11 + 5 + 0 + + + + + + + 18 + the activation of PI3K and MEK pathways is not the only mechanism of EGFR-resistance + + + + 22037177 + + + + + + + + 2012 + 7 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 28 + 10 + 42 + 0 + + + + + + + 18 + Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase. + + + + 22260839 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 11 + 25 + 0 + + + + + + + 18 + EGFR missense mutations were detected in some Japanese cases of malignant pleural and peritoneal mesothelioma. + + + + 22412050 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 11 + 25 + 0 + + + + + + + 18 + and increased gene copy number of EGFR and HER2 characterize high-grade malignancy with unfavorable prognosis in salivary gland cancer + + + + 22154363 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 11 + 5 + 0 + + + + + + + 18 + Hedgehog-EGFR regulated genes, SOX2, SOX9, JUN, CXCR4 and FGF19, are required for tumor growth. + + + + 22294553 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 11 + 4 + 0 + + + + + + + 18 + statistically significant relation was found between local recurrence of ameloblastoma and expression of EGFR + + + + 22300665 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 11 + 4 + 0 + + + + + + + 18 + In amnion cells EGFR clustering induced by 50-Hz MF depends on acid sphingomyelinase activity. + + + + 20137294 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 10 + 45 + 0 + + + + + + + 18 + The protein overexpression of EGFR was not related to a gene copy number gain in malig-nant peritoneal and pleural mesothelioma. + + + + 22449226 + + + + + + + + 2012 + 7 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 21 + 10 + 20 + 0 + + + + + + + 18 + combined expression of three genes-MYC, EGFR and FGFR2-was an independent predictor for overall survival of 27 CF-treated patients in the validation set, and also for survival of 40 chemotherapy-treated gastric cancer patients + + + + 21173787 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 11 + 35 + 0 + + + + + + + 18 + EGF receptor ubiquitination and recruitment of ESCRT protein complexes are required for trafficking-mediated downregulation of receptor activity. + + + + 22017370 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 35 + 0 + + + + + + + 18 + 2 of 40 small-cell lung cancer cases had mutations in EGFR exon 19: a female non-smoker with SCLC & adenocarcinoma, and a male smoker with SCLC & squamous cell carcinoma. + + + + 22103903 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 35 + 0 + + + + + + + 18 + Overexpression of EGFR promoted the multidrug resistance phenotypes in breast cancer cells via accelerating the G1/S phase transition. + + + + 22179693 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 34 + 0 + + + + + + + 18 + Results show that ponatinib is a potent pan-FGFR inhibitor and strongly support the investigation of ponatinib in patients with FGFR-driven cancers. + + + + 22238366 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 34 + 0 + + + + + + + 18 + EGFR expression is a poor prognostic factor for survival in patients with pancreatic cancer. + + + + 22261712 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 34 + 0 + + + + + + + 18 + Suppression of EGFR expression can significantly inhibit epithelial-mesenchymal transition of pancreatic cancer PANC-1 cells. The mechanism may be related with the down-regulation of the expression of transcription factors snail and slug. + + + + 22271412 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 34 + 0 + + + + + + + 18 + c-Met, epidermal growth factor receptor, and insulin-like growth factor-1 receptor are important for growth in uveal melanoma and independently contribute to migration and metastatic potential + + + + 22343486 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 34 + 0 + + + + + + + 18 + EGF-mediated CYR61 upregulation in HES cells involves STAT3 and is counter-regulated by the EGFR/MAPK/ERK pathway. + + + + 22401280 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 33 + 0 + + + + + + + 18 + Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. + + + + 22451678 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 33 + 0 + + + + + + + 18 + EGF, induced Ca(2+) release from the endoplasmic reticulum and Ca(2+) entry through TRPC1. Ca(2+) entry through TRPC1 conversely activated EGFR, suggesting that TRPC1 is a component of a Ca(2+)-dependent amplification of EGF-dependent cell proliferation. + + + + 22451676 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 33 + 0 + + + + + + + 18 + Propose a Systems Biology approach to understand the molecular biology of EGFR and IGF1R pathways in non-small cell lung cancer. + + + + 21620944 + + + + + + + + 2012 + 7 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 7 + 14 + 10 + 15 + 0 + + + + + + + 18 + These data suggest differences in the dimerization-blocking efficacy of EGFR monoclonal antibodies as mutant EGFR dimer configurations prevalent in glioblastoma multiforme. + + + + 22232519 + + + + + + + + 2012 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 7 + 7 + 11 + 58 + 0 + + + + + + + 18 + These findings demonstrate a key role for ErbB1 in adipogenesis and suggest that lower ErbB1 protein abundance may lead to adipose tissue dysfunction. + + + + 22238402 + + + + + + + + 2012 + 7 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 7 + 7 + 10 + 25 + 0 + + + + + + + 18 + Progression-free survival time of patients with both EGFR mutations and MET FISH positive defined by the Cappuzzo scoring system was significantly shorter than with EGFR mutations alone. + + + + 21733594 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 11 + 52 + 0 + + + + + + + 18 + Plasma EGFR mutations in the Chinese patients with advanced NSCLC is not a predictor for the response to first-line chemotherapy, but an independent prognostic factor indicating longer survival. + + + + 22340169 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 11 + 18 + 0 + + + + + + + 18 + Report efficacy of dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib in colorectal cancer. + + + + 22412142 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 11 + 18 + 0 + + + + + + + 18 + pSTAT3 was identified in the BAC component of 88% of the EGFR mutant (n=17) and 82% of the wild-type tumors (n=33). + + + + 21684622 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 55 + 0 + + + + + + + 18 + Suggest that the enhanced S1P3-EGFR signaling axis may contribute to the tumorigenesis or progression of lung adenocarcinomas. + + + + 22344462 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 53 + 0 + + + + + + + 18 + Persistent activation of signaling by the AKT-survivin pathway induced by PTEN loss underlies a mechanism of resistance to erlotinib-induced apoptosis in EGFR mutation-positive non-small cell lung cancer. + + + + 22075159 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + These experiments define a novel biological function of PIM-1 as a co-regulator of EGFR signaling. + + + + 22193779 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + This study highlights variations in the prevalence of EGFR mutations in Triple-negative breast cancers (TNBCs). + + + + 22192147 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + Protein interactions with EGFR can have different characteristics depending on the hosting cell line. + + + + 22200885 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + ADAM17 contributes to androgen-independent prostate cancer cell invasion by shedding of EGFR ligand TGF-alpha, which subsequently activates the EGFR-MEK-ERK signaling pathway, leading finally to overexpression of MMP-2 and MMP-9. + + + + 22200661 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + The observed relationships between EGFR and pEGFR indicate that high-throughput pEGFR/EGFR analyses merit further investigations and consideration for routine use in patient samples. + + + + 22228639 + + + + + + + + 2012 + 6 + 30 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 30 + 10 + 26 + 0 + + + + + + + 18 + Findings implicate EGFR -191C/A and the (CA)(n) repeat polymorphisms as risk factors for gliomas, and suggest -191C/A as a prognostic marker in glioblastoma. + + + + 21960689 + + + + + + + + 2012 + 6 + 23 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 23 + 11 + 59 + 0 + + + + + + + 18 + Data indicate that PIK3CA mutations occur in lung adenocarcinomas, usually concurrently with EGFR, KRAS, and anaplastic lymphoma kinase (ALK). + + + + 22135231 + + + + + + + + 2012 + 6 + 23 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 23 + 10 + 45 + 0 + + + + + + + 18 + aspirin (1) reduces cell surface expression of EGFR and (2) accumulates endocytosed-EGFR and -TfnR in the early/sorting endosome + + + + 22159558 + + + + + + + + 2012 + 6 + 23 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 23 + 10 + 4 + 0 + + + + + + + 18 + Human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue. + + + + 22198508 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 12 + 31 + 0 + + + + + + + 18 + Data indicate that circulating tumor DNA could potentially be used as an alternative method for EGFR mutation detection. + + + + 21976538 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 12 + 7 + 0 + + + + + + + 18 + FISH-positive EGFR expression is associated with gender and smoking status, but not correlated with the expression of ERCC1 and BRCA1 proteins in non-small cell lung cancer. + + + + 22093627 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 12 + 7 + 0 + + + + + + + 18 + Our findings suggest that EGFR/KRAS mutations do not occur in pure pulmonary squamous cell carcinoma (SQCC). + + + + 22228640 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 12 + 7 + 0 + + + + + + + 18 + Data show that EGFR expression was significantly higher in responders versus nonresponders to gefitinib. + + + + 21994417 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 11 + 28 + 0 + + + + + + + 18 + Results suggest that TWIST1 is an important driver of epithelial to mesenchymal transition in EGFR mutated cells and could be a potential marker in clinics to predict outcome in patients with EGFR mutated tumors + + + + 22272264 + + + + + + + + 2012 + 6 + 16 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 16 + 10 + 41 + 0 + + + + + + + 18 + EGFR was highly expressed and activated in the synovium of patients with rheumatoid arthritis. These findings suggest that EGFR plays a central role in the pathogenesis of RA + + + + 22393153 + + + + + + + + 2012 + 6 + 9 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 9 + 11 + 23 + 0 + + + + + + + 18 + results indicate that TGFbeta1- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies + + + + 22292774 + + + + + + + + 2012 + 6 + 9 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 9 + 10 + 26 + 0 + + + + + + + 18 + downregulation of HIF-1 through EGFR signaling seems to be required for the induction of a positive response to EGFR-targeted therapies in TNBC + + + + 21966417 + + + + + + + + 2012 + 6 + 9 + 10 + 1 + 0 + + + + + + + + + 2012 + 6 + 9 + 10 + 25 + 0 + + + + + + + 18 + This nomogram could be highly useful to predict the presence of EGFR mutations in lung adenocarcinoma in non-Asian patients when mutational profiling is not available or possible. + + + + 21778168 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 11 + 35 + 0 + + + + + + + 18 + Increasing knowledge of EGFR biology is driving more targeted or alternative approaches to cancer therapies. + + + + 22471663 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 11 + 34 + 0 + + + + + + + 18 + Lack of EGFR mutations is associated with gefitinib treatment response in adenocarcinoma of esophagogastric junction. + + + + 22252115 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 11 + 7 + 0 + + + + + + + 18 + EGFR protein overexpression is closely related to EGFR copy number in oral cavity squamous cell carcinoma + + + + 21831696 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 10 + 43 + 0 + + + + + + + 18 + Suggest that the continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib after progressive disease enhances the antitumor activity of chemotherapy. + + + + 22209766 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 10 + 42 + 0 + + + + + + + 18 + Report mutations in KRAS, EGFR, and BRAF in cholangiocarcinoma and identify therapeutic targets for tyrosine kinase inhibitors. + + + + 22178589 + + + + + + + + 2012 + 6 + 2 + 10 + 2 + 0 + + + + + + + + + 2012 + 6 + 2 + 10 + 21 + 0 + + + + + + + 18 + Nuclear phosphorylated EGFR upregulates iNOS expression and EGFR nuclear import is associated with gallbladder carcinoma + + + + 21761100 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 31 + 0 + + + + + + + 18 + EGFR expression in tissue microarrays of 240 breast cancer patients was detected by quantum dot-immunohistochemistry and spectral analysis. The prognostic value of EGFR immunofluorescence area for five-year recurrence-free survival was investigated. + + + + 22072864 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 30 + 0 + + + + + + + 18 + CAV1 is a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor. + + + + 22411794 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 30 + 0 + + + + + + + 18 + Median progression-free survival with second-line EGFR TKIs is significantly longer than second-line pemetrexed. + + + + 22116317 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 8 + 0 + + + + + + + 18 + two most commonly amplified receptor tyrosine kinase genes, EGFR and PDGFRA, were found to be present in variable proportions across the tumors, with one or the other gene predominating in certain areas of the same specimen. + + + + 22311673 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 8 + 0 + + + + + + + 18 + Identification and validation of three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer. + + + + 22333974 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 8 + 0 + + + + + + + 18 + these findings suggest that miR-542-5p may act as an important modulator of EGFR-mediated oncogenesis, with potential applications as a novel therapeutic target in lung cancer. + + + + 22426479 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 11 + 7 + 0 + + + + + + + 18 + study identified a cooperative effect of loss of BRCA1 with gain of EGFR expression that leads to increased clonal proliferation of mammary epithelial cells and may render these cells vulnerable to malignant transformation + + + + 21396117 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 10 + 46 + 0 + + + + + + + 18 + study demonstrated existing EGFR mutations in a study of 70 triple negative breast cancers in a Singapore population (8 of 70 samples); mutations included EGFR exon 19 deletions (4 of 70 samples ) and EGFR exon 21 substitutions (3 of 70 samples) + + + + 21457545 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 10 + 46 + 0 + + + + + + + 18 + Data show that IL-8 overexpression is induced by activating mutations of KRAS or EGFR in non-small cell lung cancer (NSCLC) cells. + + + + 21544811 + + + + + + + + 2012 + 5 + 26 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 26 + 10 + 46 + 0 + + + + + + + 18 + Activity of EGFR and AKT was increased in AZD6244-resistant cells. + + + + 22082529 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 44 + 0 + + + + + + + 18 + High incidence of EGFR mutations is associated with smoking and lung adenocarcinoma histology + + + + 22237264 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 43 + 0 + + + + + + + 18 + EGFR216, EGFR191, ABCG2, and AKT1 polymorphism is not associated with erlotinib response in non-small cell lung cancer. + + + + 22237259 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 43 + 0 + + + + + + + 18 + I review the studies that have highlighted the role of the JXM domain in EGFR activation. [Review] + + + + 22260689 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 43 + 0 + + + + + + + 18 + in HER1, the extracellular region asymmetry requires interactions with the plasma membrane. + + + + 22260687 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 43 + 0 + + + + + + + 18 + Binding of EGF to its receptor is positively linked with dimer assembly, but shows negative co-operativity within the dimer. + + + + 22260659 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 43 + 0 + + + + + + + 18 + antisense-mediated inhibition of mature miR-7 expression led up-regulation of EGFR and its downstream effectors, and increased radio-resistance of U251 glioma cells. + + + + 21676478 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 15 + 0 + + + + + + + 18 + Autocrine activation of epithelial-mesenchymal-transition leading to EMT is associated with a metastatic phenotype and reduced sensitivity of SCCHN cells to single-modality treatment with cetuximab or irradiation. + + + + 21665310 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 15 + 0 + + + + + + + 18 + Regulation of Double Strand Break repair by EGFR involves both the NHEJ and HR pathway, and appears to occur in most tumor cell lines regardless of p53 and K-Ras mutation status. + + + + 21665306 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 15 + 0 + + + + + + + 18 + EGFR mutation status is associated with lung adenocarcinoma. + + + + 22157369 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 14 + 0 + + + + + + + 18 + EGFR mutations, especially exon 19 deletions are associated with pulmonary tuberculosis in patients with adenocarcinoma of the lungs. + + + + 22173705 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 14 + 0 + + + + + + + 18 + EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib. + + + + 22173702 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 14 + 0 + + + + + + + 18 + the R521K polymorphism of epidermal growth factor receptor, by reducing its activation and a consequential downregulation of its target genes, including VEGF, could be a key determinant of an increased response to cetuximab-based chemotherapy + + + + 22321154 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 14 + 0 + + + + + + + 18 + a novel role for CDCP1 in EGF/EGFR-induced cell migration and indicate that targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling + + + + 22315226 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 11 + 14 + 0 + + + + + + + 18 + EGFR gain is associated with poor overall survival for lung adenocarcinoma patients and may be used as prognostic marker + + + + 21556796 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 10 + 48 + 0 + + + + + + + 18 + high glucose promotes pancreatic cancer cell proliferation by both the induction of EGF expression and transactivation of EGFR + + + + 22087246 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 10 + 47 + 0 + + + + + + + 18 + Activation of EGFR connected to AKT and ERK signaling pathways may induce anti-apoptosis and promote cell proliferation. + + + + 22088438 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 10 + 46 + 0 + + + + + + + 18 + high EGFR protein level may not necessarily indicate Tyr1068 phosphorylation and thereby receptor activation in cervical cancer. + + + + 21680035 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 10 + 24 + 0 + + + + + + + 18 + The correlation between expression of pEGFR and pAKT is indicative of activation of the PI3-K/AKT pathway through phosphorylation of EGFR in head and neck squamous cell carcinoma. + + + + 21775008 + + + + + + + + 2012 + 5 + 19 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 19 + 10 + 23 + 0 + + + + + + + 18 + EGFR-mediated apoptosis is initiated by the activated EGFR from the limiting membrane of the endosome + + + + 22102283 + + + + + + + + 2012 + 5 + 12 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 12 + 11 + 12 + 0 + + + + + + + 18 + EGFR protein overexpression in gastrointestinal cancers is common but FISH assessment showed that EGFR gene amplification is rare. A statistically significant association was found between EGFR protein overexpression & chromosome 7 polysomy. + + + + 22217347 + + + + + + + + 2012 + 5 + 12 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 12 + 11 + 11 + 0 + + + + + + + 18 + Analysis of the relationship between EGFRvIII expression and overall survival in 73 patients with newly diagnosed glioblastoma. + + + + 22241957 + + + + + + + + 2012 + 5 + 12 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 12 + 11 + 11 + 0 + + + + + + + 18 + These results demonstrate that hEAG1 channel activity is regulated by EGFR kinase at the tyrosine residues Tyr90, Try344, and Try485. + + + + 22061963 + + + + + + + + 2012 + 5 + 12 + 10 + 1 + 0 + + + + + + + + + 2012 + 5 + 12 + 10 + 4 + 0 + + + + + + + 18 + a high frequency of Q787Q mutation and a less prevalent active EGFR mutation in oral cavity squamous cell carcinoma patients in Taiwan where betel nut is commonly chewed. + + + + 21284055 + + + + + + + + 2012 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2012 + 5 + 5 + 11 + 46 + 0 + + + + + + + 18 + the incidence of EGFR and KRAS mutations in Chinese patients with adenosquamous carcinoma of the lung (ADSQ) were similar to those of Asian patients with adenocarcinoma; EGFR silent mutations accounted for a large proportion in ADSQ + + + + 21592614 + + + + + + + + 2012 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2012 + 5 + 5 + 10 + 51 + 0 + + + + + + + 18 + Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma. + + + + 22161775 + + + + + + + + 2012 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2012 + 5 + 5 + 10 + 50 + 0 + + + + + + + 18 + human airway epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signaling and bacterial adhesion. + + + + 22247545 + + + + + + + + 2012 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2012 + 5 + 5 + 10 + 4 + 0 + + + + + + + 18 + Support the rationale for routine baseline tissue-based assessment of EGFR mutations in patients with NSCLC and for treatment of mutation-positive patients with EGFR tyrosine-kinase inhibitors. + + + + 22285168 + + + + + + + + 2012 + 4 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 28 + 11 + 33 + 0 + + + + + + + 18 + In vitro studies demonstrate that EGFR activation is associated with induction of a variety of proinflammatory molecules (e.g., IL6, IL8, ICAM1), and this effect is reversed upon administration of EGFR-specific inhibitors. + + + + 21985857 + + + + + + + + 2012 + 4 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 28 + 11 + 6 + 0 + + + + + + + 18 + Adenocarcinoma is the most frequent EGFR mutation pathologic type in lung cancer. + + + + 21933587 + + + + + + + + 2012 + 4 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 28 + 10 + 28 + 0 + + + + + + + 18 + The assessment of p16, EGFR, and COX-2 allows to an integrative approach for the progression of squamous intraepithelial lesion, associated or not with the human papilloma virus infection. + + + + 22203921 + + + + + + + + 2012 + 4 + 28 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 28 + 10 + 28 + 0 + + + + + + + 18 + The clinical evidence concerning the use of monoclonal antibodies targeting the EGFR in the setting of advanced colorectal cancer. + + + + 21999128 + + + + + + + + 2012 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2012 + 4 + 21 + 11 + 29 + 0 + + + + + + + 18 + Results suggest that Rab7 is likely involved in protecting EGFR and Her2 from being degraded by the proteosome and in maintaining optimal tumor cell Akt survival signal. + + + + 21928319 + + + + + + + + 2012 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2012 + 4 + 21 + 10 + 58 + 0 + + + + + + + 18 + Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression in association with EGFR gene mutation. + + + + 21830212 + + + + + + + + 2012 + 4 + 21 + 10 + 2 + 0 + + + + + + + + + 2012 + 4 + 21 + 10 + 57 + 0 + + + + + + + 18 + Up-regulation of EGFR occurs through direct binding of HOXB7 to the EGFR promoter, enhancing transcriptional activity. + + + + 21690342 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 11 + 50 + 0 + + + + + + + 18 + Data show that elevated levels of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1a)-247R-expressing cells are responsible for EGF receptor (EGFR) transactivation. + + + + 22089237 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 11 + 49 + 0 + + + + + + + 18 + analysis of epidermal growth factor receptor (EGFR) in lung cancer + + + + 21722621 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 49 + 0 + + + + + + + 18 + An inverse correlation between VPS4B expression and EGFR abundance is observed in breast tumors, and high-grade or recurrent breast carcinomas exhibit lower VPS4B expression. + + + + 22252323 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 48 + 0 + + + + + + + 18 + PDGFRA-amplified Glioblastoma were found to have amplification of EGFR or the hepatocyte growth factor receptor gene (MET) as well. + + + + 22323597 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 48 + 0 + + + + + + + 18 + EGFRvIII, a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in human glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Dock180, a guanine nucleotide exchange factor for Rac1 + + + + 22323579 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 48 + 0 + + + + + + + 18 + EGFR copy number increases detectable in vulvar carcinomas show relationships with advanced tumour stages and the development of lymph node metastases. + + + + 22128196 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 48 + 0 + + + + + + + 18 + Molecular diagnosis of EGFR gene copy number by FISH varied largely among pathology centres, with fluctuations covering the whole range of proposed cut-offs of predictive usefulness from literature. + + + + 22130903 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 29 + 0 + + + + + + + 18 + These results suggest that cancer cells in the PNI areas could acquired a growth advantage that could be triggered by the growth factor receptors EGFR and CD74. + + + + 21748758 + + + + + + + + 2012 + 4 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 4 + 14 + 10 + 29 + 0 + + + + + + + 18 + EGFR plays a critical role in mediating nontypeable Haemophilus influenzae -induced NF-kappaB activation and inflammation. + + + + 22132240 + + + + + + + + 2012 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 4 + 7 + 11 + 28 + 0 + + + + + + + 18 + The status of the O-glycans attached to the EGFR was altered by GALNT2, changing EGFR responses after EGF binding. + + + + 21990321 + + + + + + + + 2012 + 4 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 4 + 7 + 10 + 27 + 0 + + + + + + + 18 + EGFR mutation is associated with nonsmall cell lung cancer. + + + + 21720997 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 11 + 49 + 0 + + + + + + + 18 + the structural, molecular, and clinical implications of EGFR exon 20 insertions in non-small-cell lung cancer (Review) + + + + 21764376 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 11 + 49 + 0 + + + + + + + 18 + LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis + + + + 22110740 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 11 + 48 + 0 + + + + + + + 18 + Regulation of EGFR expression is critical in lung development. [review] + + + + 22306870 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 10 + 46 + 0 + + + + + + + 18 + The EGFR-R497K polymorphism is a potential predictor for overall survival in HNSCC patients. + + + + 22287728 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 10 + 46 + 0 + + + + + + + 18 + epidermal growth factor receptor tyrosine phosphorylates MUC1, leading to an increase in its association with TLR5, thereby competitively and reversibly inhibiting recruitment of MyD88 to TLR5 and downstream signaling events. + + + + 22250084 + + + + + + + + 2012 + 3 + 31 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 31 + 10 + 5 + 0 + + + + + + + 18 + No evidence of any relationship between EGFR genotypes and tumor regression was found. + + + + 21570215 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 11 + 47 + 0 + + + + + + + 18 + EGFR mutant in non-small cell lung cancer is not associated with erlotinib resistance for Central Nervous System metastases. + + + + 21865399 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 11 + 47 + 0 + + + + + + + 18 + The mRNA levels for EGFR and its associated ligands, including HB-EGF, were induced several fold in PANC-1 and HCT116 cells in response to AM251. + + + + 21449913 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 11 + 15 + 0 + + + + + + + 18 + Ca(2+)/CaM regulates the EGFR activity by directly interacting with the CaM-BD of the receptor located at its cytosolic juxtamembrane region. + + + + 22157759 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 11 + 13 + 0 + + + + + + + 18 + Studies indicate that tumor heterogeneity and probably also previous systemic treatment may be an obstacle for correct interpretation of EGFR status in non-small cell lung cancer (NSCLC). + + + + 22130585 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 10 + 30 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. + + + + 22117074 + + + + + + + + 2012 + 3 + 24 + 10 + 1 + 0 + + + + + + + + + 2012 + 3 + 24 + 10 + 30 + 0 + + + + + + + 18 + The pooled analysis shows that the incidence of EGFR mutations in NSCLC differs according to cigarette-smoking history. The odds ratio (OR) for the EGFR mutation in non-smokers relative to smokers was 4.829. + + + + 22223435 + + + + + + + + 2012 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 17 + 12 + 24 + 0 + + + + + + + 18 + Data suggest that sustained inhibition of both EGFR and ERK1/2 leads to significant protection of the cells from IFNgamma-induced apoptosis, indicating important roles for the EGFR tyrosine kinase and ERK1/2 MAP-kinases in regulating A431 cell death. + + + + 21606674 + + + + + + + + 2012 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 17 + 11 + 46 + 0 + + + + + + + 18 + Cathepsin S plays an important role in the regulation of cell autophagy through interference with the EGFR-ERK/MAPK-signaling pathway. + + + + 22101325 + + + + + + + + 2012 + 3 + 17 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 17 + 11 + 44 + 0 + + + + + + + 18 + Interferon-gamma alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport. + + + + 22069319 + + + + + + + + 2012 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 10 + 11 + 43 + 0 + + + + + + + 18 + show that the GBM-derived epidermal growth factor receptor (EGFR) CTD deletion mutants are able to induce cellular transformation in vitro and in vivo in the absence of ligand and receptor autophosphorylation. + + + + 22001862 + + + + + + + + 2012 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 10 + 10 + 25 + 0 + + + + + + + 18 + EGFR1 expression was significantly upregulated in poorly differentiated and anaplastic thyroid carcinomas, whereas it was absent or faint in normal thyroid gland tissue and in differentiated thyroid papillary carcinomas. + + + + 22007939 + + + + + + + + 2012 + 3 + 10 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 10 + 10 + 25 + 0 + + + + + + + 18 + EGFR mutations were discordant between primary tumors and corresponding metastases in a significant portion of lung adenocarcinomas. + + + + 21729655 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 11 + 15 + 0 + + + + + + + 18 + EGFR mutations are associated with response to therapy in lung adenocarcinoma. + + + + 21729650 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 11 + 15 + 0 + + + + + + + 18 + The EGFR mutation occurred more frequently in male patients with ground grass opacity,GGO than in those without GGO. + + + + 21811765 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 11 + 15 + 0 + + + + + + + 18 + Data show that Down-regulation of c-Cbl in VHL-deficient ccRCC cells revealed that the c-Cbl and pVHL collaborated to down-regulate the activated EGFR. + + + + 21949687 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 11 + 15 + 0 + + + + + + + 18 + PDGFR-beta- and EGFR-immunoreactivity of pulmonary vessels distinguishes pulmonary arterial hypertension patients from controls + + + + 21492463 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 10 + 5 + 0 + + + + + + + 18 + Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. + + + + 22045810 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 10 + 4 + 0 + + + + + + + 18 + The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding. + + + + 22069315 + + + + + + + + 2012 + 3 + 3 + 10 + 2 + 0 + + + + + + + + + 2012 + 3 + 3 + 10 + 4 + 0 + + + + + + + 18 + triple-negative cases had a worse prognosis for relapse and death, compared with cases with EGFR, KRAS, or ALK mutations or group B triple-negative cases + + + + 22080568 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 11 + 15 + 0 + + + + + + + 18 + mechanisms of allosteric activation may have universally evolved in the ABL and EGFR regulatory complexes as a product of a functional cross-talk between the organizing alphaF-helix and conformationally adaptive alphaI-helix and alphaC-helix + + + + 21998569 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 11 + 15 + 0 + + + + + + + 18 + High EGFR is associated with tongue cancer. + + + + 22213301 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 11 + 2 + 0 + + + + + + + 18 + L858R/T790M mutant epidermal growth factor receptor is associated with lung cancer. + + + + 22213300 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 11 + 2 + 0 + + + + + + + 18 + High serum EGFR is associated with virus infection in liver carcinogenesis. + + + + 22213299 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 11 + 2 + 0 + + + + + + + 18 + epidermal growth factor receptor (EGFR) activation induces translocation of PKM2, but not PKM1, into the nucleus, where K433 of PKM2 binds to c-Src-phosphorylated Y333 of beta-catenin + + + + 22056988 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 55 + 0 + + + + + + + 18 + High EGFR expression is a tumour biomarker that can predict survival benefit from the addition of cetuximab to first-line chemotherapy in patients with advanced non-small lung cancer. + + + + 22056021 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 55 + 0 + + + + + + + 18 + p53 homolog DeltaNp63alpha enhances the oncogenic potential of pancreatic cancer cells through trans-activation of EGFR and 14-3-3sigma. + + + + 22053213 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 54 + 0 + + + + + + + 18 + increasing EGFR levels during head and neck carcinogenesis can be interpreted as a physiological response to permanent carcinogen impact on the mucosa. + + + + 21903449 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 27 + 0 + + + + + + + 18 + Inhibition of EGFR significantly suppressed the ability of overexpressed HER2 to induce enhanced signaling and cell transformation, suggesting that HER2 requires the EGFR to maximize its signaling and transformation potency + + + + 21911055 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 19 + 0 + + + + + + + 18 + HER2 seems to be a valid therapeutic target of EGFR inhibitors in HER2-addicted lung carcinomas + + + + 22199274 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 15 + 0 + + + + + + + 18 + IDH1 mutation may correlate with the benefit from VEGF(R)- versus EGFR-targeted therapy at the time of recurrence in glioma patients + + + + 22199315 + + + + + + + + 2012 + 2 + 25 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 25 + 10 + 15 + 0 + + + + + + + 18 + EGF receptor tyrosine kinase up-regulates the K(IR) 2.3 channel via phosphorylation of the Y234 residue of the WT protein. This effect may be involved in the endogenous regulation of cellular electrical activity. + + + + 21486282 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 11 + 42 + 0 + + + + + + + 18 + These findings suggest that 25-methoxyhispidol A-mediated inhibitory activity of human breast cancer cell growth might be related with the cell cycle arrest and modulation of signal transduction pathways. + + + + 21782877 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 11 + 41 + 0 + + + + + + + 18 + Results suggest that FKBP12 forms an endogenous inhibitor of EGFR phosphorylation directly involved in control of cellular EGFR activity (as in carcinoma). + + + + 22103444 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 11 + 41 + 0 + + + + + + + 18 + establish GBP1 as a previously unknown link between EGFR activity and MMP1 expression and nominate it as a novel potential therapeutic target for inhibiting GBM invasion. + + + + 22162832 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 11 + 41 + 0 + + + + + + + 18 + Data show that of the six patients harboring complex EGFR mutations with classical mutation patterns, five had positive IHC staining. + + + + 21858063 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 11 + 7 + 0 + + + + + + + 18 + Data indicate that curcumin potentiates antitumor activity of gefitinib through inhibition of proliferation, EGFR phosphorylation, and altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell. + + + + 21858220 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 10 + 35 + 0 + + + + + + + 18 + TIEG1 inhibits breast cancer cell invasion by inhibition of the EGFR signaling pathway. + + + + 22025675 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 10 + 35 + 0 + + + + + + + 18 + EGFR signalling in neoplastic stromal cells may contribute to disease progression through promoting stromal cell proliferation and osteoclastogenesis in giant cell tumour of bone + + + + 22034878 + + + + + + + + 2012 + 2 + 18 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 18 + 10 + 35 + 0 + + + + + + + 18 + EGFR and c-Met may interact in a synergistic manner in the oncogenesis and development of non-small cell lung cancer. Expressions were higher in smokers than in nonsmokers. + + + + 21354913 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 11 + 0 + 0 + + + + + + + 18 + EGFR mutations are associated with the response to therapy in non-small cell lung cancer. + + + + 21841502 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 58 + 0 + + + + + + + 18 + Validated liquid-based cytology for EGFR and KRAS gene mutations and set appropriate laser capture microdissection and direct sequencing benchmarks. + + + + 21945923 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 58 + 0 + + + + + + + 18 + Review: Tumour-associated activating mutations in EGFR can identify patients with non-small-cell lung cancer who are likely to have a good response to tyrosine kinase inhibitors. + + + + 22039281 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 58 + 0 + + + + + + + 18 + Oxidation of the EGFR active site modulates kinase activity + + + + 22158416 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 58 + 0 + + + + + + + 18 + multiple receptor tyrosine kinases are amplified in a subset of glioblastoma subclones, epidermal growth factor receptor, MET and platelet-derived growth factor receptor alpha + + + + 22137795 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 58 + 0 + + + + + + + 18 + Concurrent exon 19 EGFR mutation and ALK rearrangement is associated with response to erlotinib in lung adenocarcinoma. + + + + 22005476 + + + + + + + + 2012 + 2 + 11 + 10 + 2 + 0 + + + + + + + + + 2012 + 2 + 11 + 10 + 29 + 0 + + + + + + + 18 + Data indicate that neither total nor full-length EGFR protein level, or autophosphorylation status, showed prognostic significance. + + + + 21737508 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 11 + 34 + 0 + + + + + + + 18 + Routine epidermal growth factor receptor (EGFR) screening using diagnostic samples is fast and feasible even on samples with poor cellularity and DNA content. + + + + 22036089 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 11 + 33 + 0 + + + + + + + 18 + There was no significant difference in EGFR mutation frequency between the primary and metastatic nonsmall cell lung tumors. + + + + 22011285 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 11 + 33 + 0 + + + + + + + 18 + Two oncogenic mutants of EGFR are fully active independently of EGF and highly resistant to the therapeutic and endogenous inhibitors cetuximab, lapatinib and MIG6. + + + + 22101934 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 11 + 33 + 0 + + + + + + + 18 + Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of epidermal growth factor receptor + + + + 21939503 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 10 + 4 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small cell lung cancer. + + + + 21949883 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 10 + 4 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene mutations are associated with treatment response in advanced non-small cell lung cancer + + + + 21986139 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 10 + 4 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR) is over-expressed in 40-80% of patients with non-small-cell lung cancer (NSCLC). + + + + 22006985 + + + + + + + + 2012 + 2 + 4 + 10 + 1 + 0 + + + + + + + + + 2012 + 2 + 4 + 10 + 4 + 0 + + + + + + + 18 + Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling + + + + 21979953 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 12 + 16 + 0 + + + + + + + 18 + Mutations in RAS, particularly HRAS, are frequent in cutaneous squamous-cell carcinomas and keratoacanthomas that develop in patients treated with vemurafenib. + + + + 22256804 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 12 + 16 + 0 + + + + + + + 18 + The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status in colorectal carcinomas + + + + 22050898 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 11 + 49 + 0 + + + + + + + 18 + EGFR and MAPK phosphorylation is found in chloracne tissues. + + + + 18761794 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 11 + 47 + 0 + + + + + + + 18 + analysis of radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr + + + + 22077956 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 11 + 25 + 0 + + + + + + + 18 + EGFR and MET coordinate to drive non-small cell lung carcinoma tumorigenesis. + + + + 21687954 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 11 + 12 + 0 + + + + + + + 18 + Prospective EGFR immunohistochemistry analysis in an adult cohort comprising 750 infiltrative gliomas, is described. + + + + 21839716 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 10 + 58 + 0 + + + + + + + 18 + a model in which Usp18 inhibition promotes up-regulation of miR-7, which in turn inhibits EGFR expression and the tumorigenic activity of cancer cells. + + + + 21592959 + + + + + + + + 2012 + 1 + 28 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 28 + 10 + 55 + 0 + + + + + + + 18 + EGFR and mTOR signaling pathways are deregulated in ES. + + + + 21821699 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 11 + 43 + 0 + + + + + + + 18 + DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. + + + + 21741919 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 11 + 41 + 0 + + + + + + + 18 + EGFR-activating mutations are associated with treatment response in non-small cell lung cancer. + + + + 21921847 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 11 + 21 + 0 + + + + + + + 18 + EGFR mutation-positive status can predict better response to combined chemoradiotherapy + + + + 21924037 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 11 + 21 + 0 + + + + + + + 18 + EGFR mutations are associated with treatment response in lung cancer. + + + + 21869714 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 59 + 0 + + + + + + + 18 + both EGFR and HRAS mutations are rare events in the carcinogenesis of cutaneous squamous cell carcinoma, and therefore, only a small subgroup of patients will benefit from the screening for mutations + + + + 21771097 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 36 + 0 + + + + + + + 18 + EGFR mutations are associated with docetaxel response in lung cancer. + + + + 21681119 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 36 + 0 + + + + + + + 18 + EGFR expressed on head and neck squamous cell carcinoma cells induces a specific immune response in vivo. + + + + 21970318 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 36 + 0 + + + + + + + 18 + explored the tumorigenic potential of the EGFR mutations that we had previously identified and their sensitivity to two different EGFR tyrosine kinase inhibitors + + + + 21953075 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 20 + 0 + + + + + + + 18 + both primary and lymph-node metastases have relatively consistent EGFR mutations and EGFR mutations are not relevant to changes in c-Met gene copy number. + + + + 21982684 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 19 + 0 + + + + + + + 18 + The prognostic significance of the mRNA expression of nine genes in the EGFR and NF-kappaB pathways, was investigated. + + + + 21951562 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 19 + 0 + + + + + + + 18 + EGFR is an important factor enhancing the malignancy of MDR breast cancer cells, partially, inducing MDR. + + + + 21805028 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 11 + 0 + + + + + + + 18 + These results implicate both signal propagation and the cortical cytoskeleton in reduced mobility of signaling-competent erbB1 dimers. + + + + 22020299 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 11 + 0 + + + + + + + 18 + up regulation of EGFR, cyclin D1 and h TERT proteins correlates with advanced stage in squamous cell carcinoma of the larynx + + + + 20373052 + + + + + + + + 2012 + 1 + 21 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 21 + 10 + 9 + 0 + + + + + + + 18 + genetic polymorphism is assopciated with recurrent non-small-cell lung cancer in patients receiving gefitinib + + + + 21444121 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 12 + 1 + 0 + + + + + + + 18 + While no significant difference in survival was observed between EGFR exon 19 deletion and L858R mutation, EGFR exon 19 deletion was predictive of longer PFS following EGFR TKI treatment in patients with advanced NSCLC. + + + + 21725039 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 11 + 13 + 0 + + + + + + + 18 + Low baseline sEGFR is associated with reduced survival in advanced non-small-cell lung cancer + + + + 21729651 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 11 + 13 + 0 + + + + + + + 18 + Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling. + + + + 21934107 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 11 + 12 + 0 + + + + + + + 18 + a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells + + + + 21925169 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 11 + 12 + 0 + + + + + + + 18 + Rho-kinase signaling pathway plays a suppressive role in the intracellular vesicle trafficking of pEGFR via the endocytic pathway. + + + + 21847509 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 11 + 12 + 0 + + + + + + + 18 + These findings suggest that APPL1 is required for EGFR signaling by regulation of EGFR stabilities through inhibition of Rab5. + + + + 22037462 + + + + + + + + 2012 + 1 + 14 + 10 + 1 + 0 + + + + + + + + + 2012 + 1 + 14 + 10 + 45 + 0 + + + + + + + 18 + EGFR sequences showed somatic missense mutations in exons 18 and 20 at a frequency of 2.1% and 0.4% and Somatic SNPs in exons 20 and 21 at a frequency of about 3.1% and 0.4% respectively. + + + + 22026926 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 12 + 45 + 0 + + + + + + + 18 + EGFR mutations were associated with pulmonary pleomorphic carcinoma. + + + + 21409490 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 11 + 37 + 0 + + + + + + + 18 + The Pulmonary Pathology Working Group of the Austrian Society of Pathology, after intense discussions and in consensus with Oncologists and Pulmonologists, recommends a priori EGFR mutation analysis for all cases of adenocarcinoma. + + + + 21604158 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 10 + 48 + 0 + + + + + + + 18 + High-level EGFR immunohistochemical expression correlated with and predicted EGFR amplification in basal-like carcinoma of the breast. + + + + 21884205 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 10 + 47 + 0 + + + + + + + 18 + EGFR pathway inhibitors block bronchial hyperplasia in an organotypic culture model + + + + 21505178 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 10 + 21 + 0 + + + + + + + 18 + Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway. + + + + 21831204 + + + + + + + + 2012 + 1 + 7 + 10 + 2 + 0 + + + + + + + + + 2012 + 1 + 7 + 10 + 20 + 0 + + + + + + + 18 + Genotypes with the variant allele of EGFR R521K SNP confer a risk reduction to develop colorectal cancer. + + + + 21896992 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 12 + 31 + 0 + + + + + + + 18 + EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. + + + + 21975932 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 12 + 31 + 0 + + + + + + + 18 + This study aimed to analyze the relationships between IPF and specific EGF receptor family functional polymorphisms. + + + + 21132379 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 12 + 31 + 0 + + + + + + + 18 + EGFR gene mutations were detected in 42 cases NSCLC (26.9%). Twenty-three patients with EGFR mutations received gefitinib, with an overall response rate (partial response [PR]) of 54.5% and disease control rate (PR + stable disease) of 86.4%. + + + + 21527506 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 12 + 3 + 0 + + + + + + + 18 + results provide a detailed and quantitative demonstration of how regulators and scaffolds can collaborate to fine-tune the ligand-dependent sensitivity of EGFR endocytosis and ERK activation + + + + 21829671 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 11 + 26 + 0 + + + + + + + 18 + It was shown that lysophosphatidic acid 5 receptor transactivated the epidermal growth factor receptor and that inhibition of epidermal growth factor receptor blocked lysophosphatidic acid 5 receptor-dependent activation of NHE3. + + + + 21832242 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 11 + 26 + 0 + + + + + + + 18 + Data show that EI-04 as a superior cancer therapeutic in treating EGFR and IGF-1R pathway responsive tumors. + + + + 21393993 + + + + + + + + 2011 + 12 + 31 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 31 + 10 + 42 + 0 + + + + + + + 18 + Inhibition of EGFR and Her2 phosphorylation by Lapatinib is shown to be associated with the inhibition of Akt phosphorylation. + + + + 21786419 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 11 + 22 + 0 + + + + + + + 18 + EGFR signalling is involved in Snail protein overexpression + + + + 19604315 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 11 + 16 + 0 + + + + + + + 18 + EGFR mutation is an early event in the pathogenesis of lung adenocarcinoma and may facilitate the tumor into aggressive behavior + + + + 21512404 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 10 + 54 + 0 + + + + + + + 18 + The EGFR unprecedented and activated conformation could be sustained by simultaneous alterations in membrane structure under oxidative stress. + + + + 21853092 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 10 + 53 + 0 + + + + + + + 18 + targeting the EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization + + + + 19432811 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 10 + 28 + 0 + + + + + + + 18 + Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors + + + + 21897861 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 10 + 4 + 0 + + + + + + + 18 + Inhibition of the EGFR expression prevents immortalization of human cervical cells by Human Papillomavirus type 16. + + + + 21982220 + + + + + + + + 2011 + 12 + 24 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 24 + 10 + 4 + 0 + + + + + + + 18 + Higher dosage of the epidermal growth factor receptor mutant allele is associated with lung adenocarcinoma. + + + + 21587084 + + + + + + + + 2011 + 12 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 17 + 11 + 40 + 0 + + + + + + + 18 + Data show that uPAR and its crosstalk pathways with EGFRvIII emerge as logical targets for therapeutics development in GBM. + + + + 21896743 + + + + + + + + 2011 + 12 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 17 + 11 + 40 + 0 + + + + + + + 18 + A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway. + + + + 21857648 + + + + + + + + 2011 + 12 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 17 + 11 + 39 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with treatment response in non-small cell lung cancer. + + + + 21681118 + + + + + + + + 2011 + 12 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 17 + 10 + 38 + 0 + + + + + + + 18 + epithelial growth factor receptor mutations in cerebrospinal fluid is associated with lung adenocarcinoma suspected of neoplastic meningitis. + + + + 21610522 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 12 + 6 + 0 + + + + + + + 18 + time course experiments with different kinase inhibitors demonstrated that GPR109A induced ERK1/2 activation via the matrix metalloproteinase/epidermal growth factor receptor transactivation pathway at both early and later time points + + + + 21768093 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 12 + 5 + 0 + + + + + + + 18 + EGFR mutation is associated with erlotinib accumulation in brain metastases from non-small cell lung cancer. + + + + 21847041 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 12 + 5 + 0 + + + + + + + 18 + EGFR mutation combined with HER2/3 expression is a significant predictor for gefitinib efficacy on Chinese patients with advanced non-small cell lung cancer. + + + + 20038315 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 11 + 28 + 0 + + + + + + + 18 + Overexpressions of c-Cbl, Cbl-b, and EGFR are closely related to the invasion and progression of gastric carcinoma. + + + + 20038312 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 11 + 28 + 0 + + + + + + + 18 + Activation of epidermal growth factor receptor promotes squamous carcinoma cell migration and invasion via inducing epithelial mesenchymal transformation-like phenotype change and matrix metallproteinase-9-mediated degradation of E-cadherin + + + + 21557297 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 11 + 19 + 0 + + + + + + + 18 + EGFR overexpression is associated with skin lesions. + + + + 21934337 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 11 + 19 + 0 + + + + + + + 18 + results show beta1-integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy. + + + + 21478906 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 52 + 0 + + + + + + + 18 + distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S) + + + + 21832070 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 51 + 0 + + + + + + + 18 + our results indicate that IDHR132H mutation correlates significantly with p53 and inversely with EGFR mutations + + + + 21845536 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 51 + 0 + + + + + + + 18 + data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio + + + + 21508312 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 27 + 0 + + + + + + + 18 + Data show that mandatory overexpression of hGSTA4 by transient transfection in KYSE30 cells and attenuation of HNE-induced EGFR phosphorylation. + + + + 21751261 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 26 + 0 + + + + + + + 18 + SMURF2-mediated protective ubiquitination of EGFR may be responsible for EGFR overexpression in certain tumors. + + + + 21750651 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 26 + 0 + + + + + + + 18 + Mutations in EGFR is associated with drug resistance and epithelial to mesenchymal transition in lung cancer. + + + + 21597390 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 26 + 0 + + + + + + + 18 + We found a significant correlation of HER2 with human epidermal growth factor receptor 3 (HER3/erbB3), epidermal growth factor receptor 1 (EGFR/HER1/erbB1) and urokinase plasminogen receptor (uPAR) in breast cancer tissues. + + + + 21391216 + + + + + + + + 2011 + 12 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 12 + 10 + 10 + 26 + 0 + + + + + + + 18 + The frequency of EGFR mutation in Chinese non-small cell lung cancer patients is higher than that in Westerners, but the frequency of K-ras mutation is quite opposite. + + + + 21122380 + + + + + + + + 2011 + 12 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 3 + 11 + 30 + 0 + + + + + + + 18 + high prevalence of EGFR mutations in non-smal cell lung cancer patients in India + + + + 21315473 + + + + + + + + 2011 + 12 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 3 + 11 + 23 + 0 + + + + + + + 18 + deletion of NFKBIA and amplification of EGFR show a pattern of mutual exclusivity in glioblastoma multiforme[review] + + + + 21778941 + + + + + + + + 2011 + 12 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 3 + 11 + 22 + 0 + + + + + + + 18 + Epidermal growth factor receptor overexpression is associated with malignant pleural mesothelioma + + + + 21437912 + + + + + + + + 2011 + 12 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 3 + 10 + 52 + 0 + + + + + + + 18 + There is a positive correlation between the EGFR and c-Met protein expression and the differentiation of non-small cell lung cancer. + + + + 21223687 + + + + + + + + 2011 + 12 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 12 + 3 + 10 + 34 + 0 + + + + + + + 18 + KRAS mutation status is a treatment effect modifier for anti-EGFR antibodies in metastatic colorectal cancer + + + + 21550229 + + + + + + + + 2011 + 11 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 26 + 11 + 25 + 0 + + + + + + + 18 + epidermal growth factor receptor (EGFR) was elevated in breast cancer cases versus controls + + + + 21761335 + + + + + + + + 2011 + 11 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 26 + 11 + 25 + 0 + + + + + + + 18 + Suppressing expression of EGFR inhibited cell proliferation. + + + + 21965733 + + + + + + + + 2011 + 11 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 26 + 11 + 24 + 0 + + + + + + + 18 + E. coli O157 : H7-derived flagellin induces rapid phosphorylation of the epidermal growth factor receptor, as an early event in intestinal epithelial cell signalling, and that this is required for the release of the pro-inflammatory cytokine IL-8. + + + + 21546588 + + + + + + + + 2011 + 11 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 26 + 10 + 36 + 0 + + + + + + + 18 + EGFR copy number status is a more reliable indicator than protein overexpression of the survival rate in oral tongue squamous cell carcinoma. + + + + 21852109 + + + + + + + + 2011 + 11 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 26 + 10 + 35 + 0 + + + + + + + 18 + Results of this study strongly support the potential of KL-6 as a diagnostic biomarker for life-threatening EGFR tyrosine kinase inhibitor induced interstitial lung disease. + + + + 21791074 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 11 + 24 + 0 + + + + + + + 18 + Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells. Up-regulation of HO-1 exerts as a host cellular defense mechanism against EV71 infection in SK-N-SH cells. + + + + 21321939 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 11 + 15 + 0 + + + + + + + 18 + Hogbarn dust (HDE) activates EGFRs and their downstream signaling, and EGFR activation is required for some but not all airway epithelial cell responses to HDE. + + + + 21441380 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 10 + 59 + 0 + + + + + + + 18 + Data suggest that drug-sensitive and drug-resistant EGFR-mutant cells exhibit differential growth kinetics, with the drug-resistant cells showing slower growth. + + + + 21734175 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 10 + 59 + 0 + + + + + + + 18 + We propose paxillin as a novel cellular target for converging H. pylori-induced EGFR, FAK/Src, and PI3K/Akt signaling to regulate cytoskeletal reorganization and IL-8 production in part, thus contributing to the H. pylori-induced diseases. + + + + 21757638 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 10 + 59 + 0 + + + + + + + 18 + EGFR immunohistochemistry is not a suitable criterion for reliably selecting patients for anti-EGFR treatment. EGFR in situ hybridization may be reliably performed with high accuracy, allowing treatment decisions for lung cancer. + + + + 21947301 + + + + + + + + 2011 + 11 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 19 + 10 + 35 + 0 + + + + + + + 18 + This reveals that the L834R mutation introduces conformational changes in both states, adjusting the relative stabilities of active and inactive conformations and hence the activation of the EGFR kinase. + + + + 21717480 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 12 + 17 + 0 + + + + + + + 18 + EGFR and KRAS status should be tested in metastasis regardless of known mutations of the primary tumor. + + + + 21497370 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 11 + 32 + 0 + + + + + + + 18 + The EGFR was efficiently dephosphorylated in treated patients as compared to a control cohort of 12 patients + + + + 21471286 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 10 + 56 + 0 + + + + + + + 18 + Integration of aCGH and gene expression data identified copy number aberrations and novel genes with prognostic potential in OAC. + + + + 21478220 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 10 + 56 + 0 + + + + + + + 18 + As the dose of gefitinib increased, a gradual decrease in EGFR tyrosine phosphorylation was detected in pediatric glioblastoma and neuroblastoma cells. + + + + 22029196 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 10 + 25 + 0 + + + + + + + 18 + The ultrastructure of EGFR is examined. + + + + 21822280 + + + + + + + + 2011 + 11 + 12 + 10 + 2 + 0 + + + + + + + + + 2011 + 11 + 12 + 10 + 25 + 0 + + + + + + + 18 + BCRP/ABCG2 expression may be a predictor for poor efficacy of gefitinib treatment, and targeting BCRP/ABCG2 may broaden the use of gefitinib in patients with wtEGFR. + + + + 21731744 + + + + + + + + 2011 + 11 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 5 + 12 + 50 + 0 + + + + + + + 18 + our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation. + + + + 21590492 + + + + + + + + 2011 + 11 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 5 + 11 + 59 + 0 + + + + + + + 18 + a novel variant of EGFR, which lacks the entire exon 4 sequence, is widely expressed in human tumors, and it seems to be associated with tumorigenesis. + + + + 21532887 + + + + + + + + 2011 + 11 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 5 + 11 + 12 + 0 + + + + + + + 18 + Significantly fewer EGFR (epidermal growth factor receptor)-mutated tumors engrafted (P = 0.03). + + + + 21081655 + + + + + + + + 2011 + 11 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 11 + 5 + 10 + 39 + 0 + + + + + + + 18 + Our data suggest EGFR signaling to play a role in cell migration and brain infiltration of adaCP. + + + + 21562037 + + + + + + + + 2011 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2011 + 10 + 29 + 12 + 15 + 0 + + + + + + + 18 + C-erbB-2 and EGFR might have a synergetic effect in the development and progress of nasopharyngeal carcinoma. Co-expression closely correlates with cell proliferation status. + + + + 21473138 + + + + + + + + 2011 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2011 + 10 + 29 + 11 + 50 + 0 + + + + + + + 18 + Combined targeting of c-Met and EGFR resulted in an enhanced inhibition of tumor volumes accompanied by a decreased number of proliferating cells and increased apoptosis compared with single agent treatment in vivo. + + + + 21622718 + + + + + + + + 2011 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2011 + 10 + 29 + 10 + 35 + 0 + + + + + + + 18 + EGFR-activating mutations are associated with treatment responses of lung adenocarcinoma . + + + + 21810691 + + + + + + + + 2011 + 10 + 29 + 10 + 2 + 0 + + + + + + + + + 2011 + 10 + 29 + 10 + 21 + 0 + + + + + + + 18 + Rapid and accurate ranking of binding affinities of epidermal growth factor receptor sequences with selected lung cancer drugs + + + + 21227963 + + + + + + + + 2011 + 10 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 22 + 11 + 37 + 0 + + + + + + + 18 + Combined targeting of c-Met and EGFR leads to increased xenograft antitumor activity + + + + 21423210 + + + + + + + + 2011 + 10 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 22 + 11 + 24 + 0 + + + + + + + 18 + EGFR expression may play a role in breast cancer proliferation, but appears unlikely to modify tumour pathology. + + + + 21586793 + + + + + + + + 2011 + 10 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 22 + 11 + 4 + 0 + + + + + + + 18 + The EGFR T790M mutation is the main molecular mechanisms responsible for acquired resistance to gefitinib or erlotinib in patients with non-small cell lung cancer harboring a mutation in the EGFR gene. + + + + 21062933 + + + + + + + + 2011 + 10 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 22 + 10 + 59 + 0 + + + + + + + 18 + summarizes both preclinical and clinical available data regarding EGFR genomic alterations as prognostic and predictive factors + + + + 21622099 + + + + + + + + 2011 + 10 + 15 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 15 + 11 + 29 + 0 + + + + + + + 18 + EGFR mutations were discordant between the primary tumor and the corresponding metastases in non-small cell lung cancer + + + + 21645456 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 12 + 5 + 0 + + + + + + + 18 + the expression and clinical relevance of c-Cbl, Cbl-b and EGFR in non-small cell lung cancer + + + + 21645455 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 12 + 5 + 0 + + + + + + + 18 + The presence of sensitizing EGFR mutations correlates with radiographic response. + + + + 21558399 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 11 + 38 + 0 + + + + + + + 18 + Polymorphism in epidermal growth factor receptor intron 1 is associated with treatment response in esophageal cancer. + + + + 21298351 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 11 + 26 + 0 + + + + + + + 18 + Data show that both EGFR-TKIs increased ATG5 and ATG7 at the mRNA or protein levels (Figure 3), confirming the induction of autophagy by EGFR-TKIs. + + + + 21655094 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 10 + 23 + 0 + + + + + + + 18 + Detection of EGFR expression and mutation in Pulmonary blastoma + + + + 21292787 + + + + + + + + 2011 + 10 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 8 + 10 + 4 + 0 + + + + + + + 18 + Increased EGFR gene copy number is associated with head and neck squamous cell carcinoma. + + + + 21467228 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 12 + 8 + 0 + + + + + + + 18 + huEGFRt serves as a highly efficient selection epitope for chimeric antigen receptor(+) T cells + + + + 21653320 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 12 + 7 + 0 + + + + + + + 18 + These data indicate that Neisseria gonorrhoeae modulates the activity and cellular distribution of host EGFR, facilitating their invasion. + + + + 21501367 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 12 + 7 + 0 + + + + + + + 18 + EGFR mutations are associated with drug resistance in non-small cell lung cancer. + + + + 21258250 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 11 + 35 + 0 + + + + + + + 18 + Data sugggest that The inhibition of EGFR and VEGFR2 by vandetanib and its tremendous in vivo antitumor activity against ATC make it an attractive candidate for further preclinical and clinical development for the treatment of this cancer. + + + + 21220477 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 11 + 26 + 0 + + + + + + + 18 + Data show distinct significant correlations between TITF-1 protein expression and DNA copy gain with mutations in the lung adenocarcinoma-prevalent EGFR and KRAS oncogenes. + + + + 21257719 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 11 + 25 + 0 + + + + + + + 18 + Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients. + + + + 21300759 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 11 + 25 + 0 + + + + + + + 18 + EGFR overexpression was seen in some of the malignant hidradenomas,atypical hidr- adenomas, and benign hidradenomas. + + + + 20534988 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 10 + 13 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with pelvic relapse in advanced cancer of the cervix treated with chemoradiotherapy. + + + + 20859196 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 10 + 13 + 0 + + + + + + + 18 + EGFR mutations in exons 19 (deletion mutation) and 21 (L858R mutation) predict a longer progression-free survival in patients with advanced non-small cell lung cancer. + + + + 21518597 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 10 + 4 + 0 + + + + + + + 18 + study concludes that none of the glioblastomas with a TP53 mutation had the EGFRvIII variant + + + + 21665183 + + + + + + + + 2011 + 10 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 10 + 1 + 10 + 4 + 0 + + + + + + + 18 + EGFR appears to be involved in progression and metastasis of a subset of melanomas + + + + 21352258 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 11 + 49 + 0 + + + + + + + 18 + The extremely low incidence of EGFR protein expression and gene amplification in Saudi breast cancer patients as compared to Western populations is most probably ethnically related. + + + + 21702909 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 11 + 31 + 0 + + + + + + + 18 + Increasing sialylation and fucosylation could attenuate EGFR-mediated invasion of lung cancer cells. However, incorporation of the core fucose by alpha1,6-fucosylatransferase (FUT8) would promote EGFR dimerization and phosphorylation. + + + + 21709263 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 10 + 58 + 0 + + + + + + + 18 + EGFR gene alterations are associated with lung cancer. + + + + 21623266 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 10 + 55 + 0 + + + + + + + 18 + demonstrate here that breast cancer cells harbouring PIK3CA mutations are selectively sensitive to mTOR allosteric and kinase inhibitors. However, cells with PTEN loss of function are not sensitive to these drugs + + + + 21383692 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 10 + 23 + 0 + + + + + + + 18 + the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients + + + + 21874828 + + + + + + + + 2011 + 9 + 24 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 24 + 10 + 15 + 0 + + + + + + + 18 + Manipulation of miR-145 expression modulates EGFR mRNA expression. + + + + 21289483 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 11 + 45 + 0 + + + + + + + 18 + Germ-line mutations in EGFR are rare but may contribute to oncogenesis. + + + + 21575252 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 11 + 19 + 0 + + + + + + + 18 + The role of EGFR in the upregulation of inflammatory markers in A549 cells exposed to cadmium is reported. + + + + 21605009 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 11 + 4 + 0 + + + + + + + 18 + REVIEW: role of the epidermal growth factor receptor in the mechanism of colorectal cancer + + + + 21356164 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 10 + 54 + 0 + + + + + + + 18 + Repeat numbers of CA SSR1 might not be a useful prognostic factor for oral squamous cell carcinoma in Taiwanese and the status of CA SSR1 of EGFR may be a useful prognostic factor. + + + + 21530363 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 10 + 54 + 0 + + + + + + + 18 + increased EGFR protein levels and gene copy numbers (not gene amplification alone) have prognostic significance in the investigated Hungarian head and neck squamous cell carcinoma patient population. + + + + 21498106 + + + + + + + + 2011 + 9 + 17 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 17 + 10 + 35 + 0 + + + + + + + 18 + In patients, with chronic hepatitis C associated the EGF genotype G/G with increased risk for hepatocellular carcinoma; differences in its frequency among black and white subjects might account for differences in HCC incidence between these groups. + + + + 21440548 + + + + + + + + 2011 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 10 + 11 + 0 + 0 + + + + + + + 18 + Automated EGFR SISH, in combination with KRAS mutation analysis, can be a useful and easily applicable technique in routine diagnostic practise for selecting patients for anti-EGFR therapy. + + + + 21694725 + + + + + + + + 2011 + 9 + 10 + 10 + 2 + 0 + + + + + + + + + 2011 + 9 + 10 + 11 + 0 + 0 + + + + + + + 18 + These studies indicate that TSP1 disrupts the endothelial barrier through EGFR/ErbB2 activation although additional signals are necessary in cells with low receptor expression. + + + + 21531776 + + + + + + + + 2011 + 9 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 3 + 11 + 39 + 0 + + + + + + + 18 + Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells + + + + 21525012 + + + + + + + + 2011 + 9 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 3 + 11 + 39 + 0 + + + + + + + 18 + in non-small cell lung cancer (NSCLC), EGFR mutation was independently associated with the female gender, negative expression of progesterone receptor, and negative expression of aromatase + + + + 21524465 + + + + + + + + 2011 + 9 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 3 + 11 + 39 + 0 + + + + + + + 18 + role of EGFRvIII in cohort of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with or without EGFR tyrosine kinase inhibitor; study confirms EGFRvIII mutation is common in R/M SCCHN and may play role in prognosis + + + + 21352589 + + + + + + + + 2011 + 9 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 3 + 11 + 1 + 0 + + + + + + + 18 + MUC5AC expression is regulated by a bidirectional circuit between Notch and EGFR signaling pathways. + + + + 21622856 + + + + + + + + 2011 + 9 + 3 + 10 + 1 + 0 + + + + + + + + + 2011 + 9 + 3 + 10 + 41 + 0 + + + + + + + 18 + GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding + + + + 21571640 + + + + + + + + 2011 + 8 + 27 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 27 + 11 + 43 + 0 + + + + + + + 18 + Results suggest that EGFR mutation is not a prognostic marker in Korean patients with advanced lung adenocarcinoma who had not been treated with EGFR tyrosine kinase inhibitors. + + + + 21411993 + + + + + + + + 2011 + 8 + 27 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 27 + 11 + 26 + 0 + + + + + + + 18 + Results suggest that the heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma. + + + + 21730270 + + + + + + + + 2011 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 20 + 10 + 49 + 0 + + + + + + + 18 + Galectin-3 regulates MUC1 and epidermal growth factor receptor (EGFR) internalization and subcellular localization, ERK1,2 activation downstream of the EGFR and EGFR nuclear translocation in pancreatic cancer cells. + + + + 21258405 + + + + + + + + 2011 + 8 + 20 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 20 + 10 + 9 + 0 + + + + + + + 18 + Decreasing the expression level of EGFR, rather than inhibiting its tyrosine kinase activity, may enhance the efficiency of EGFR- targeted therapy for prostate cancer. + + + + 21656832 + + + + + + + + 2011 + 8 + 13 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 13 + 10 + 48 + 0 + + + + + + + 18 + findings show VEGFR-2 and VEGFR-3 expression are markers of a poor prognosis in patients with surgically resected colorectal adenocarcinoma, whereas EGFR has a minor influence + + + + 21635552 + + + + + + + + 2011 + 8 + 13 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 13 + 10 + 48 + 0 + + + + + + + 18 + data indicate that EGFR T790M exists in pretreatment non-small cell lung cancer at low levels irrespective of histologic types + + + + 21635547 + + + + + + + + 2011 + 8 + 13 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 13 + 10 + 48 + 0 + + + + + + + 18 + Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. + + + + 21487020 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 11 + 13 + 0 + + + + + + + 18 + EGFR mutations in exon 19 and exon 21 in non-small cell lung cancer patients may relate to the tumor sites + + + + 21067269 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 11 + 2 + 0 + + + + + + + 18 + Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. + + + + 21407195 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 11 + 2 + 0 + + + + + + + 18 + EGFR exon 19 deletions and exon 21 point mutation are predictive biomarkers for response to icotinib hydrochloride as second line treatment or above. + + + + 21362302 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 11 + 2 + 0 + + + + + + + 18 + the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathways + + + + 21264347 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 10 + 37 + 0 + + + + + + + 18 + Data show that EGF mutants with faster kinetic on-rates stimulate increased EGFR activation compared to wild-type EGF. + + + + 21439278 + + + + + + + + 2011 + 8 + 6 + 10 + 1 + 0 + + + + + + + + + 2011 + 8 + 6 + 10 + 25 + 0 + + + + + + + 18 + five EGFR mutations out of 16 patients with NSCLC of African-American descent + + + + 21132006 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 11 + 11 + 0 + + + + + + + 18 + Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck. + + + + 21325639 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 11 + 10 + 0 + + + + + + + 18 + HA facilitates TGF-beta1-dependent fibroblast proliferation through promoting interaction between CD44 and EGFR, which then promotes specific MAPK/ERK activation, inducing cellular proliferation. + + + + 21454519 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 11 + 5 + 0 + + + + + + + 18 + TFF2 is mitogenic in cholangiocarcinoma via EGFR/MAPK activation. + + + + 21472131 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 11 + 5 + 0 + + + + + + + 18 + Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma. + + + + 21508367 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 11 + 5 + 0 + + + + + + + 18 + EGFR, like Bcl-2 and p53, was significantly up-regulated in tumors from elderly patients. + + + + 21388911 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 10 + 37 + 0 + + + + + + + 18 + demonstrate that cells transfected with SSTR1 or SSTR1/5 negatively regulates EGF mediated effects attributed to the inhibition of EGFR phosphorylation. + + + + 21419811 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 10 + 37 + 0 + + + + + + + 18 + Findings suggest an improved method to identify EGFRvIII-expressing gliomas in vivo that are best suited for treatment with therapeutic EGFR antibodies. + + + + 21245103 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 10 + 31 + 0 + + + + + + + 18 + Findings suggest strategies to target nucleolin as a general approach to inhibiting ErbB- and Ras-driven cancers. + + + + 21257709 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 10 + 12 + 0 + + + + + + + 18 + data demonstrate glucocorticoid receptor (GR) deficiency results in delayed and impaired eyelid closure; defects are due, at least in part, to lack of antagonism between GR and epidermal growth factor receptor signaling + + + + 21136383 + + + + + + + + 2011 + 7 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 30 + 10 + 12 + 0 + + + + + + + 18 + EGFR was found to be expressed in 61.8% of brain gliomas, with strongly positive expression in 12.2% of them + + + + 21455841 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 11 + 8 + 0 + + + + + + + 18 + EGFR gene mutations were frequently observed in not only non-small-cell lung cancer (NSCLC), but also in ovarian cancer in Japanese patients. + + + + 21057220 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 46 + 0 + + + + + + + 18 + analysis of resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer + + + + 21135146 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 31 + 0 + + + + + + + 18 + The aim of this study was to elucidate the interaction between EGFR ligands and their signaling pathway and MMP1 expression which might be closely related with breast cancer pathogenesis. + + + + 21440529 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 31 + 0 + + + + + + + 18 + Conserved intramolecular non-covalent bond networks are identified across ErbB family kinase EGFR that emerge from sequence homology and lead to conserved dynamic characteristics as well as function. + + + + 21426301 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 30 + 0 + + + + + + + 18 + The density of microvascularization was assessed using CD34 monoclonal antibody (hot spot technique), the expression of angiogenic factors VEGFR, EGFR and COX-2 were determined in tumor biopsies by specific immunohistochemistry techniques + + + + 21424032 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 30 + 0 + + + + + + + 18 + Gastric carcinoma of the mucinous adenocarcinoma type collected from older male patients may harbour EGFR mutations. + + + + 21436633 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 25 + 0 + + + + + + + 18 + Studies indicate that Assessment of EGFR status by gene copy number and/or mutation analysis has proven to be predictive of response to anti-TKI inhibitors. + + + + 21400669 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 25 + 0 + + + + + + + 18 + our study has revealed an asymmetric conformation of human EGFR in contact with the plasma membrane that shares features with that in Drosophila EGFR, suggesting the structural basis for negative cooperativity is conserved from invertebrates to humans. + + + + 21444717 + + + + + + + + 2011 + 7 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 23 + 10 + 25 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene mutations is associated with squamous cell lung carcinoma. + + + + 21318227 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 50 + 0 + + + + + + + 18 + Trastuzumab plus chemotherapy in gastric cancer overexpressing HER-2 and EGFR + + + + 21346384 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 36 + 0 + + + + + + + 18 + analysis of synergistic effects of epidermal growth factor receptor antibodies on unliganded ErbB dimers and oligomers + + + + 21495621 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 36 + 0 + + + + + + + 18 + The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue. + + + + 20120862 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 11 + 0 + + + + + + + 18 + Simultaneously blocking EGFR and COX-2 mediated pathways would significantly inhibit the growth of the CNE-2 cell line, increase G1 arrest and reduce the expression levels of p-EGFR and COX-2. + + + + 20120857 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 11 + 0 + + + + + + + 18 + Local haplotype structures across the EGFR gene may favor the development of cellular malignancies and thus significantly confer risk to the occurrence of EGFR mutations in NSCLC, particularly the exon 19 microdeletions. + + + + 21292812 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 10 + 0 + + + + + + + 18 + ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking. + + + + 21275903 + + + + + + + + 2011 + 7 + 16 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 16 + 10 + 10 + 0 + + + + + + + 18 + high tumor CB(1) receptor expression at diagnosis augments the deleterious effects of a high pEGFR expression upon disease-specific survi + + + + 21203460 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 12 + 18 + 0 + + + + + + + 18 + suppression of CXCR4 inhibits EGFRvIII-mediated breast cancer cell invasion and proliferation + + + + 21454012 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 12 + 9 + 0 + + + + + + + 18 + constitutively active H-Ras can confer resistance to anti-EGFR therapy in cancer cells + + + + 21411223 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 10 + 59 + 0 + + + + + + + 18 + Allele-specific qPCR assays for the most frequent activating mutations in EGFR, KRAS, BRAF and PIK3CA in tumor-positive fine needle cytological aspirates were compared against histological material of primary tumors. + + + + 21408138 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 10 + 49 + 0 + + + + + + + 18 + Data show that neurostatin inhibits epidermal growth factor receptor signaling pathways, blocking activation of MAPKs and PI3K pathways, interferes in the cell cycle progression, and promotes generation of angiogenic and invasive responses. + + + + 20801220 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 10 + 5 + 0 + + + + + + + 18 + Identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. These receptor tyrosine kinases mediate HCV entry by regulating CD81-claudin-1 co-receptor associations and viral glycoprotein-dependent membrane fusion. + + + + 21516087 + + + + + + + + 2011 + 7 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 9 + 10 + 5 + 0 + + + + + + + 18 + quantification of EGFR and HER3 mRNA expression in pretreatment biopsies may be useful to identify patients who are at risk of developing metastases + + + + 20824716 + + + + + + + + 2011 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 2 + 10 + 50 + 0 + + + + + + + 18 + COX-2 and EGFR are overexpressed in non-small cell lung cancer. + + + + 21385353 + + + + + + + + 2011 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 2 + 10 + 19 + 0 + + + + + + + 18 + increasing cell motility is down to the production of matrix metalloproteinase 9, which degrades the basement membrane during tumor invasion, and metastases are caused by the activation of EGFR + + + + 21270615 + + + + + + + + 2011 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 2 + 10 + 3 + 0 + + + + + + + 18 + these results suggest that a considerable proportion of NSCLC in Chinese population showed discrepancy in KRAS and EGFR mutation status between primary tumors and corresponding metastases. + + + + 21414214 + + + + + + + + 2011 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 7 + 2 + 10 + 3 + 0 + + + + + + + 18 + EGFR and NF-KB expression was negatively correlated with radiosensitivity in human nasopharyngeal carcinoma. + + + + 19947250 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 15 + 4 + 0 + + + + + + + 18 + airway epithelial exposure to Pseudomonas fluorescens can trigger antiapoptotic responses via EGFR + + + + 21343351 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 14 + 50 + 0 + + + + + + + 18 + A859T EGFR mutation is associated with lung cancer. + + + + 21317745 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 14 + 21 + 0 + + + + + + + 18 + EGFR mutation is associated with response to therpay in non-small cell lung cancer. + + + + 21317742 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 14 + 21 + 0 + + + + + + + 18 + A direct association between EGFR mutations and ER beta expression in lung cancer cell lines is lacking. + + + + 21498706 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 14 + 20 + 0 + + + + + + + 18 + HER overexpression orchestrates broad changes in the tumor microenvironment by altering the secretion of a diverse variety of biologically active proteins. + + + + 21320340 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 13 + 58 + 0 + + + + + + + 18 + There was no statistically significant correlation between EGFR expression and clinical stage, age, histology, tumor size, tumor grade, lymph vascular space invasion, lymph node status and disease recurrence. + + + + 20405295 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 13 + 27 + 0 + + + + + + + 18 + EGFR related mutational status and association to clinical outcome in metastatic colorectal cancer. + + + + 21439039 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 13 + 27 + 0 + + + + + + + 18 + Lung adenocarcinomas harboring mutations in EGFR exon 19 or 21 are associated with improved treatment response. + + + + 21150674 + + + + + + + + 2011 + 6 + 25 + 12 + 53 + 0 + + + + + + + + + 2011 + 6 + 25 + 13 + 6 + 0 + + + + + + + 18 + the expression of CD133 and Her-1 may be correlative with prognosis in triple-negative breast cancer. + + + + 21276138 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 32 + 0 + + + + + + + 18 + EGFR mutations are associated with drug sensitivity in non-small-cell lung cancer. + + + + 21029366 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 17 + 0 + + + + + + + 18 + Quantitative analysis of EGFR mRNA expression could be useful in predicting prognosis and sensitivity to gemcitabine in pancreatic ductal adenocarcinoma patients. + + + + 21243324 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 17 + 0 + + + + + + + 18 + VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis. + + + + 21262974 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 17 + 0 + + + + + + + 18 + EGFR-mutated lung cancer: a paradigm of molecular oncology. + + + + 21165163 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 9 + 0 + + + + + + + 18 + Results describe an open, mass spectrometry-based approach to identify tyrosine phosphorylations associated with AEGFR, and have identified STAT5 as a new target for this receptor. + + + + 21214269 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 8 + 0 + + + + + + + 18 + EGFR mutations and amplifications in 23 adenosquamous carcinomas of lung + + + + 21502435 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 11 + 8 + 0 + + + + + + + 18 + The expression of EGFR, Ki67, p16 in middle ear cholesteatoma was significantly higher compared with controls. + + + + 19157151 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 10 + 57 + 0 + + + + + + + 18 + Calcium-induced apoptosis in bladder cancer cells is delayed by HER1 receptor activation involving the Akt and PLCgamma signalling pathways. + + + + 21087080 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 10 + 56 + 0 + + + + + + + 18 + Lung cancer in never-smoker appears to be a distinct entity from lung cancer in smoker, with specific molecular characteristics such as frequent EGFR mutations. + + + + 21420271 + + + + + + + + 2011 + 6 + 18 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 18 + 10 + 35 + 0 + + + + + + + 18 + Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Review. + + + + 21474065 + + + + + + + + 2011 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 4 + 11 + 47 + 0 + + + + + + + 18 + Biglycan impinges on the expression of total EGFR and possibly, on the cell-surface expression of the receptors, playing a critical role in the regulation of chondrocyte and pericellular matrix homeostasis. + + + + 20367117 + + + + + + + + 2011 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 4 + 10 + 53 + 0 + + + + + + + 18 + HSV-1 entered endosomes using either EGF or an EGFR-specific single chain antibody for receptor recognition. + + + + 21382632 + + + + + + + + 2011 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 4 + 10 + 51 + 0 + + + + + + + 18 + Expression rates of EGFR and Ki-67 in squamous cell carcinoma of nasal cavity and paranasal sinuses were significantly higher than that in nasal inverted papilloma and nasal polyps. + + + + 17674766 + + + + + + + + 2011 + 6 + 4 + 10 + 1 + 0 + + + + + + + + + 2011 + 6 + 4 + 10 + 11 + 0 + + + + + + + 18 + The contiguous angiomyolipoma (AML) demonstrated strong positivity for EGFR, a feature not observed in isolated AMLs. + + + + 21325256 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 11 + 28 + 0 + + + + + + + 18 + Data provide substantial evidence that APP and cystatin C are target secreted proteins of EGFR in NPC, and upregulation of secretory APP by EGFR may be involved in the pathogenesis of NPC. + + + + 20882990 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 11 + 19 + 0 + + + + + + + 18 + EGFR activation by its potent ligand, transforming growth factor (TGF)-alpha, induces reactivation of EGFR via binding of endogenously produced CCL20 to its receptor CCR6 in NCI-H292 tumor cells, exaggerating the mucin production in NCI-H292 cells. + + + + 21300824 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 11 + 0 + 0 + + + + + + + 18 + Injury and activation of purinergic receptors and direct activation of EGFR via EGF induce distinct downstream pathways. + + + + 21356361 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 10 + 53 + 0 + + + + + + + 18 + Data suggest that accurate definition of the EGFR status could improve prognostic stratification and suggest a possible role for EGFR-directed therapies in PC patients. + + + + 21266046 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 10 + 50 + 0 + + + + + + + 18 + data indicate HER1 signaling (mediated by HBEGF; involving PIK3 signaling and phosphorylation of HER1) is an important component of differentiation of proliferative extravillous trophoblasts (ET) into invasive ET; HER1 likely involved in placentation + + + + 20739666 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 10 + 30 + 0 + + + + + + + 18 + HER2, but not EGFR gene amplification, is frequently observed in KRAS and BRAF wild type colorectal cancer patients + + + + 20563851 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 10 + 8 + 0 + + + + + + + 18 + study to correlate EGFR expression between primary colorectal cancer and liver metastatic sites, and to assess mutational status in the EGFR kinase domain; EGFR expression in the primary tumor site was not predictive of its level in the metastasis + + + + 20595818 + + + + + + + + 2011 + 5 + 28 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 28 + 10 + 8 + 0 + + + + + + + 18 + Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. + + + + 21209099 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 11 + 13 + 0 + + + + + + + 18 + The production of MUC5AC in human nasal epithelial cells is regulated via the expression and activation of epidermal growth factor receptor signaling pathway. + + + + 19558858 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 43 + 0 + + + + + + + 18 + Phosphorylation sites related to activating mutations in EGFR as well as sensitivity to erlotinib were identified using 31 lung cancer cell lines. + + + + 21080693 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + results suggest that EGFR activation and downstream signaling depend on interactions of EGFR with PIP(2) and point to the basic juxtamembrane domain's critical involvement in these interactions + + + + 21107857 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + EGFR extracellular domain forms dimer that can take diverse configurations in solvent environments + + + + 21275429 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation. + + + + 21212278 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes. + + + + 21252234 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + TGF-alpha and EGFR were overexpressed, correlated with each other and associated with the pathological parameters in papillary thyroid carcinoma. + + + + 21240064 + + + + + + + + 2011 + 5 + 21 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 21 + 10 + 10 + 0 + + + + + + + 18 + A significant correlation between EGFR expression at the invasive margin and the presence of budding was seen + + + + 20635387 + + + + + + + + 2011 + 5 + 14 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 14 + 10 + 48 + 0 + + + + + + + 18 + High Epidermal growth factor receptor and caveolin-1 coexpression is associated with supratentorial ependymomas. + + + + 21059755 + + + + + + + + 2011 + 5 + 14 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 14 + 10 + 47 + 0 + + + + + + + 18 + Case Report: EGFR V843I mutation confers predisposition to lung adenocarcinoma and tyrosine kinase inhibitor resistance. + + + + 21172876 + + + + + + + + 2011 + 5 + 14 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 14 + 10 + 46 + 0 + + + + + + + 18 + data identify NF-kappaB as a potential companion drug target, together with EGFR, in EGFR-mutant lung cancers and provide insight into the mechanisms by which tumour cells escape from oncogene dependence + + + + 21430781 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 11 + 24 + 0 + + + + + + + 18 + EGFR T790M mutation resistance to EGFR-tyrosine kinase inhibitors is overcome by vascular endothelial growth factor inhibitors. + + + + 21252723 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 11 + 10 + 0 + + + + + + + 18 + Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations are associated with non-small cell lung cancer patients + + + + 21252721 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 11 + 10 + 0 + + + + + + + 18 + The epidermal growth factor receptor-L861Q mutation increases kinase activity without leading to enhanced sensitivity toward epidermal growth factor receptor kinase inhibitors. + + + + 21252719 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 11 + 10 + 0 + + + + + + + 18 + Study observed that CREB was phosphorylated following transactivation of EGFR by c-Src in EV71-infected cells. + + + + 21268077 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 11 + 10 + 0 + + + + + + + 18 + This is the first study to show that DJ-1 immunoreactivity is present, and robust, in most glioblastomas (GBMs), and that DJ-1 staining intensity in GBMs varies directly with p53 nuclear immunoreactivity and inversely with EGFR amplification. + + + + 20497343 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 10 + 59 + 0 + + + + + + + 18 + EGFR, PI3Kp110 and PTEN expression is a common feature of neuroblastoma + + + + 21225506 + + + + + + + + 2011 + 5 + 7 + 10 + 1 + 0 + + + + + + + + + 2011 + 5 + 7 + 10 + 47 + 0 + + + + + + + 18 + Data provided a mechanistic description of the disorders of mutated EGFR signaling networks, which could facilitate the development of a systematic strategy toward controlling disease-related cell signaling. + + + + 21085658 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 11 + 7 + 0 + + + + + + + 18 + There was no difference between the frequencies of EGFR mutations in African American patients, when compared with whites. + + + + 21107288 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 11 + 7 + 0 + + + + + + + 18 + Exon 19/21 mutations and high EGFR copy is associated with response to adjuvant chemotherapy in non-small cell lung cancer. + + + + 21107284 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 11 + 7 + 0 + + + + + + + 18 + Study describes a role for ERbeta in the modulation of cell proliferation and EGFR activation. + + + + 21124760 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 11 + 7 + 0 + + + + + + + 18 + more than 60% of non-small cell lung carcinomas (NSCLCs) express EGFR + + + + 20887192 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 10 + 54 + 0 + + + + + + + 18 + epidermal growth factor receptor exon 19 deletion is associated with Miliary never-smoking adenocarcinoma of the lung. + + + + 21178715 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 10 + 42 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with small cell lung cancer. + + + + 21178714 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 10 + 42 + 0 + + + + + + + 18 + Data show that [18F]F-PEG6-IPQA preferentially covalent binds to the L858R mutant EGFR kinase domain. + + + + 21220318 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 10 + 42 + 0 + + + + + + + 18 + These data indicate that the activation and/or overexpression of SST receptors along with the inhibition of EGFR will serve as an important therapeutic approach in the treatment of ErbB-positive tumors. + + + + 21190959 + + + + + + + + 2011 + 4 + 30 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 30 + 10 + 35 + 0 + + + + + + + 18 + Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion + + + + 21257711 + + + + + + + + 2011 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 23 + 11 + 16 + 0 + + + + + + + 18 + Data show that ErbB3 appears to be critically involved in EGFR signaling as evidenced by its profound effect on cellular proliferation and its ability to influence response to EGFR-targeted therapy. + + + + 20647770 + + + + + + + + 2011 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 23 + 11 + 10 + 0 + + + + + + + 18 + Src pathway and EGFR pathway play different roles in the proliferation of cervical cancer cells and PP2 efficiently reduces cervical cancer cell proliferation by reduction of both Src and EGFR activity. + + + + 21052789 + + + + + + + + 2011 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 23 + 10 + 47 + 0 + + + + + + + 18 + Data indicate that that a constitutively active transforming form of Src, the E378G mutant, as well as v-Src enhance ADAM17-mediated shedding of the EGFR ligand TGFalpha. + + + + 20871631 + + + + + + + + 2011 + 4 + 23 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 23 + 10 + 13 + 0 + + + + + + + 18 + IL-6 stimulates shedding of EGF-R ligands and transactivation of EGF-R in normal prostate epithelial cells, which may be an important mechanism to promote cell proliferation in inflammatory prostate. + + + + 21111811 + + + + + + + + 2011 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2011 + 4 + 16 + 14 + 21 + 0 + + + + + + + 18 + Sequence analysis of the EGFR-TK domain, revealed the presence of (G2607A) polymorphism at exon 20. The genotypes AA and GA were found respectively in 39 and 16 cases. + + + + 21215239 + + + + + + + + 2011 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2011 + 4 + 16 + 13 + 26 + 0 + + + + + + + 18 + The expression of EGFR was correlated with stage, lymph node metastasis, histological grade and relapse of laryngeal cancer. + + + + 19954019 + + + + + + + + 2011 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2011 + 4 + 16 + 13 + 13 + 0 + + + + + + + 18 + APC activates Tie2, via a mechanism requiring, in sequential order, the receptors, endothelial protein C receptor, protease-activated receptor-1, and EGF receptor, which selectively enhances the PI3K/Akt signaling to enhance junctional complexes + + + + 21173154 + + + + + + + + 2011 + 4 + 16 + 10 + 2 + 0 + + + + + + + + + 2011 + 4 + 16 + 12 + 32 + 0 + + + + + + + 18 + Activation of EGFR and its subsequent interaction with PKCdelta under inflammatory conditions might positively be attributed to the neoplastic transformation of normal esophageal epithelia. + + + + 21155880 + + + + + + + + 2011 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 9 + 11 + 5 + 0 + + + + + + + 18 + The overexpressions of VEGF-C and EGFR genes are closely related to lymph node metastasis. VEGF-C mRNA and EGFR mRNA are valuable biomarkers for early diagnosis, clinical prediction and prognosis for lung cancer. + + + + 21159248 + + + + + + + + 2011 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 9 + 11 + 5 + 0 + + + + + + + 18 + The expression of EGFR mRNA in tumor tissue was positively correlated with EGFR protein in plasma. + + + + 21159244 + + + + + + + + 2011 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 9 + 11 + 5 + 0 + + + + + + + 18 + EGFR might be, for the cases of colorectal cancer with high EGFR expression in metastases, a target for radionuclide therapy + + + + 21109951 + + + + + + + + 2011 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 9 + 10 + 58 + 0 + + + + + + + 18 + Estrogen receptor alpha36 mediates nongenomic estrogen signaling through the epidermal growth factor receptor/Src/extracellular signal-regulated kinase signaling pathway in estrogen receptor-negative breast cancer cells. + + + + 20935677 + + + + + + + + 2011 + 4 + 9 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 9 + 10 + 19 + 0 + + + + + + + 18 + enhanced EGFR expression on keratinocytes in OLP lesions and up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to carcinogenesis and pathogenesis of OLP. + + + + 20952227 + + + + + + + + 2011 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 2 + 11 + 3 + 0 + + + + + + + 18 + Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas. + + + + 21087480 + + + + + + + + 2011 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 2 + 10 + 46 + 0 + + + + + + + 18 + Rhinovirus induced MUC5AC in bronchial epithelial cells in vitro by activating an epidermal growth factor receptor-dependent cascade culminating in specificity protein-1 transactivation of the MUC5AC promoter. + + + + 20525715 + + + + + + + + 2011 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 2 + 10 + 19 + 0 + + + + + + + 18 + When patients with lung adenocarcinomas who had EGFR mutations developed pulmonary metastases, they tended to be diffuse and random, including military metastases. + + + + 20886633 + + + + + + + + 2011 + 4 + 2 + 10 + 1 + 0 + + + + + + + + + 2011 + 4 + 2 + 10 + 19 + 0 + + + + + + + 18 + our results suggest that the expression of EGFR in adrenocortical tumors indicates a malignant phenotype + + + + 20693985 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 12 + 11 + 0 + + + + + + + 18 + Data suggest that PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation. + + + + 21258366 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 11 + 17 + 0 + + + + + + + 18 + age at the time of diagnosis in female patients with non-small cell lung cancer may be associated with the frequency of EGFR mutations. + + + + 21155184 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 11 + 17 + 0 + + + + + + + 18 + non-small cell lung cancer specimens harboring EGFR activating mutations are more likely to express low ERCC1 mRNA levels. + + + + 20975603 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 11 + 7 + 0 + + + + + + + 18 + Mutations of EGFR, BRAF, and KRAS in adenocarcinoma were mutually exclusive and inversely correlated with RASSF1A methylation + + + + 21102258 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 10 + 46 + 0 + + + + + + + 18 + extracellular HSP90alpha transactivates EGFR/ErbB1 through TLR4 and a PKCdelta/c-Src pathway, which induces ATP release and cytosolic Ca(2+) increase and finally favors glioblastoma cell migration. + + + + 21127066 + + + + + + + + 2011 + 3 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 26 + 10 + 46 + 0 + + + + + + + 18 + Activation of the EGF-EGFR signaling pathway is associated with the development of CK19-positive hepatocellular carcinoma (HCC), and the EGF-induced increase in growth abilities of HCC may account for the poor prognosis of the patients. + + + + 20856226 + + + + + + + + 2011 + 3 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 19 + 11 + 29 + 0 + + + + + + + 18 + Both antiestrogen sensitive and antiestrogen resistant breast cancer cells showed the ability to switch between ERalpha and ErbB signaling depending on the applied treatment, thus supporting combined therapy targeting both receptor systems. + + + + 19697122 + + + + + + + + 2011 + 3 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 19 + 11 + 15 + 0 + + + + + + + 18 + Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis + + + + 21083608 + + + + + + + + 2011 + 3 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 19 + 10 + 53 + 0 + + + + + + + 18 + K497 EGFR polymorphism is associated with sensitivity to inhibitors in head and neck squamous cell carcinomas. + + + + 21273581 + + + + + + + + 2011 + 3 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 19 + 10 + 37 + 0 + + + + + + + 18 + High EGFR expression is associated with tamoxifen-resistance in breast cancer. + + + + 21273576 + + + + + + + + 2011 + 3 + 19 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 19 + 10 + 37 + 0 + + + + + + + 18 + telomerase expression and activity are induced through both direct phosphorylation of hTERT by phospho-AKT as well as PI3K-dependent transcriptional regulation involving Hif1-alpha as a key transcription factor + + + + 21156006 + + + + + + + + 2011 + 3 + 12 + 10 + 3 + 0 + + + + + + + + + 2011 + 3 + 12 + 11 + 33 + 0 + + + + + + + 18 + EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner. + + + + 20962853 + + + + + + + + 2011 + 3 + 12 + 10 + 3 + 0 + + + + + + + + + 2011 + 3 + 12 + 10 + 50 + 0 + + + + + + + 18 + Data indicated that the mitochondrial-localized EGFR is independent of its internalization and may be correlated with cell survival and participate in the ligand-induced programmed cell death. + + + + 20929928 + + + + + + + + 2011 + 3 + 12 + 10 + 3 + 0 + + + + + + + + + 2011 + 3 + 12 + 10 + 21 + 0 + + + + + + + 18 + In migratory cells ablation of myosin VI or optineurin inhibits the polarized delivery of the epidermal growth factor receptor into the leading edge and leads to profound defects in lamellipodia formation. + + + + 20604900 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 11 + 30 + 0 + + + + + + + 18 + V3 isoform of versican interferes with CD44 and the CD44-EGFR/ErbB2 interaction, altering the signaling pathways, such as ERK1/2 and p38 MAPK, that regulate cell proliferation and migration + + + + 21078678 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 11 + 30 + 0 + + + + + + + 18 + Studies indicate the involvement of EGFR(s) in regulating events of GI cancers during advancing age. + + + + 20491625 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 11 + 9 + 0 + + + + + + + 18 + data demonstrate that the tethering arm plays an important role in supporting cooperativity in ligand binding + + + + 21047778 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 10 + 42 + 0 + + + + + + + 18 + P2Y6 receptors and ADAM17 mediates the low-dose gamma-radiation-induced activation of EGFR. + + + + 21268712 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 10 + 42 + 0 + + + + + + + 18 + EGFR and HER-2 expression is variable in embryonal brain tumors + + + + 20962551 + + + + + + + + 2011 + 3 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 3 + 5 + 10 + 35 + 0 + + + + + + + 18 + A strong positive correlation between EGFR amplification and EGFR overexpression and a negative association of EGFR amplification and EGFR overexpression with p53 immunopositivity was observed. + + + + 20702468 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 11 + 25 + 0 + + + + + + + 18 + Mutations in EGFR is associated with adenocarcinoma of the lung. + + + + 20881644 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 11 + 19 + 0 + + + + + + + 18 + Data show that Spry2 can enhance the response of colon cancer cells to gefitinib by increasing the expression of phosphorylated and total EGFR. + + + + 20624167 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 11 + 10 + 0 + + + + + + + 18 + Results suggest that overexpression of EGFR protein and increased copy number or amplification of the EGFR gene occur relatively frequently in primary TGCTs, and may play roles in the formation of invasive cancer and in the progression. + + + + 20608935 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 11 + 10 + 0 + + + + + + + 18 + these results unveil a critical role of EGFR acetylation that regulates EGFR function, which may have an important clinical implication. + + + + 21094134 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 11 + 10 + 0 + + + + + + + 18 + Report on the clinical utility of reflex testing of resected stage I through III lung adenocarcinomas for EGFR and KRAS mutatations. + + + + 20933246 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 58 + 0 + + + + + + + 18 + TGFA/EGFR signaling contributes to the proliferation of papillary thyroid carcinomas cells. + + + + 20877637 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 49 + 0 + + + + + + + 18 + Serine/threonine phosphorylation reduces the binding affinity between the TKB domain of c-Cbl and its target proteins, EGFR and Sprouty2. + + + + 20877636 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 49 + 0 + + + + + + + 18 + cIAP2 upregulated by E6 via EGFR/PI3K/AKT cascades may contribute to cisplatin resistance, revealing that the EGFR or PI3K inhibitor combined with cisplatin may improve the chemotherapeutic efficacy in HPV-infected lung cancer. + + + + 20959404 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 49 + 0 + + + + + + + 18 + Data show that inhibition of PA hydrolysis provokes internalization of inactive EGFR, accompanied by a transient increase in PA levels and PDE4s activity. + + + + 20554760 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 38 + 0 + + + + + + + 18 + EGFR is overexpressed during the histological progression in Barrett's esophagus tissues + + + + 21157443 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 37 + 0 + + + + + + + 18 + TGF-beta-enhanced EGFR signalling may be an important contributor to barrier dysfunction and increased epithelial vulnerability in response to house dust mites + + + + 20351035 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 19 + 0 + + + + + + + 18 + Constitutive activation of EGFR/Akt/mTOR pathway was present in defined subset of nonsmall cell lung carcinomas. + + + + 21040950 + + + + + + + + 2011 + 2 + 26 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 26 + 10 + 5 + 0 + + + + + + + 18 + EGFR gene mutation is associated with non-small cell lung cancer. + + + + 20871269 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 46 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with lung cancer. + + + + 20871266 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 46 + 0 + + + + + + + 18 + complex EGFR mutations is associated with different efficacy to gefitinib in non-small cell lung cancer. + + + + 20808254 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 46 + 0 + + + + + + + 18 + EGFR mutations promote the growth of NSCLC, but may not be a factor of predicting prognosis. + + + + 20979823 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 42 + 0 + + + + + + + 18 + In nonsmall cell lung cancer patients with brain metastases, EGFR mutation status is associated with improved survival + + + + 20627894 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 30 + 0 + + + + + + + 18 + results demonstrate that CHFR loss might be critical for the tumorigenesis of NSCLC in patients with a history of smoking and induces tumors of a more malignant phenotype than the EGFR mutation + + + + 20473935 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 11 + 9 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with better response to therapy in non-small cell lung cancer. + + + + 20697298 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 59 + 0 + + + + + + + 18 + High EGFR expression, copy number and mutation is associated with lung adenocarcinomas. + + + + 20637128 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 50 + 0 + + + + + + + 18 + Pulmonary adenocarcinoma specimens were prepared for staining by two antibodies that recognise products of in-frame deletions in exon 19 (E746_A750del) and a point mutation at codon 858 in exon 21 (L858R) of the EGFR gene. + + + + 21187519 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 49 + 0 + + + + + + + 18 + In a group of clinically selected patients, EGFR and KRAS analysis was able to define distinct molecular subsets of lung adenocarcinoma. + + + + 21187500 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 49 + 0 + + + + + + + 18 + Cbl ubiquitin ligase plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR-Vav2 signaling. + + + + 20940296 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 37 + 0 + + + + + + + 18 + The novel EGFR mutations identified are activating mutations responsive to erlotinib. The mut+ subset have a 'relative' improved outcome. + + + + 20942962 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 8 + 0 + + + + + + + 18 + insight into the ErbB2-driven anchorage independence of tumor cells and provide a new mechanism for regulation of EGFR and beta1 integrin expression in ECM-detached cells + + + + 20956544 + + + + + + + + 2011 + 2 + 5 + 10 + 1 + 0 + + + + + + + + + 2011 + 2 + 5 + 10 + 8 + 0 + + + + + + + 18 + Knockdown of RQCD1 reduced the Akt phosphorylation level that was induced by epidermal growth factor (EGF) stimulation + + + + 20878056 + + + + + + + + 2011 + 1 + 29 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 29 + 10 + 58 + 0 + + + + + + + 18 + Immunohistochemical analysis of p-EGFR may be useful to predict responses to TKI therapy, although future studies are necessary. + + + + 20939760 + + + + + + + + 2011 + 1 + 29 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 29 + 10 + 36 + 0 + + + + + + + 18 + ErbB-1 shows absent immunoreactivity in meningioma and indicates a level similar to that of ErbB-1 in normal peripheral nerve. + + + + 20547458 + + + + + + + + 2011 + 1 + 29 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 29 + 10 + 9 + 0 + + + + + + + 18 + Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis + + + + 20840671 + + + + + + + + 2011 + 1 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 22 + 11 + 3 + 0 + + + + + + + 18 + Results indicate that downregulation of survivin plays a pivotal role in gefitinib-induced apoptosis in EGFR mutation-positive NSCLC cells. + + + + 21159653 + + + + + + + + 2011 + 1 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 22 + 10 + 44 + 0 + + + + + + + 18 + p53 and EGFR mutations are uncommon in lymphoepithelioma-like carcinomas (LELC), indicating that these genes are not the important events in carcinogenesis for this tumor subtype. + + + + 21070477 + + + + + + + + 2011 + 1 + 22 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 22 + 10 + 28 + 0 + + + + + + + 18 + PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells + + + + 20923765 + + + + + + + + 2011 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2011 + 1 + 15 + 11 + 16 + 0 + + + + + + + 18 + Results suggest that LTD induces EGF receptor transactivation through the release of HB-EGF in human bronchial epithelial cells with downstream release of CXCL8. + + + + 20889674 + + + + + + + + 2011 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2011 + 1 + 15 + 11 + 5 + 0 + + + + + + + 18 + molecular beacon-based approach enabled rapid and sensitive detection of the EGFR mutation (T790M) in NSCLC with in situ fluorescence imaging, which can be directed to determine various treatment options in patients with cancer + + + + 20805561 + + + + + + + + 2011 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2011 + 1 + 15 + 10 + 32 + 0 + + + + + + + 18 + EGFR oligomerization is the result of EGFR signaling and enhances EGFR internalization + + + + 20940297 + + + + + + + + 2011 + 1 + 15 + 10 + 2 + 0 + + + + + + + + + 2011 + 1 + 15 + 10 + 10 + 0 + + + + + + + 18 + 2 cases of pulmonary adenocarcinoma with unique microcystic growth pattern; Q787Q polymorphism was found in microcystic component but not in papillary component; findings illustrate intratumoral heterogeneity of EGFR gene polymorphism + + + + 20653783 + + + + + + + + 2011 + 1 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 8 + 10 + 55 + 0 + + + + + + + 18 + There was a substantial increase of NHEJ activity, when EGFR was activated by EGF as determined for two different reporter cell lines (A549.EJ and H1299.EJ) and, vice versa, a reduction was seen when EGFR signalling was blocked by Cetuximab or erlotinib. + + + + 20615764 + + + + + + + + 2011 + 1 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 8 + 10 + 37 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR) pathway is the main regulator of cell function and cancer development. [review] + + + + 21129606 + + + + + + + + 2011 + 1 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 8 + 10 + 35 + 0 + + + + + + + 18 + membranous EGFR expression is associated with increased gene copy number in triple-negative breast carcinoma + + + + 21156237 + + + + + + + + 2011 + 1 + 8 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 8 + 10 + 16 + 0 + + + + + + + 18 + miR-21 inhibitor might interrupt the activity of EGFR pathways, independently of PTEN status + + + + 20113523 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 34 + 0 + + + + + + + 18 + Study shows that chromogenic in situ hybridization is a valid method to detect EGFR gene copy number in cell blocks from fine needle aspirates of primary/metastatic lung neoplasms. + + + + 20843314 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 34 + 0 + + + + + + + 18 + data show that EGFR gene copy number and KRAS mutation status are neither predictive nor prognostic factors for pathological tumour response and disease-free survival in locally advanced rectal cancer patients treated with preoperative chemoradiation + + + + 20842128 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 34 + 0 + + + + + + + 18 + Expression level of EGFR protein and mutation frequency of KRAS gene in primary tumors were higher than that in metastases. + + + + 20840818 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 34 + 0 + + + + + + + 18 + Overexpressions of nuclear EGFR is associated with non-small cell lung cancer. + + + + 20631637 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 24 + 0 + + + + + + + 18 + astrocytic ErbB signaling in neuron-glia interactions has significance for the physiology of the mature central nervous system, as exemplified by the central control of reproduction within the hypothalamus--REVIEW + + + + 20685225 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 24 + 0 + + + + + + + 18 + EGFR genome modulation in the CD44+/CD24-/low subpopulation of the breast cancer cell line MDA-MB-468 leads to different coexisting subclones + + + + 20199686 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 24 + 0 + + + + + + + 18 + Data show that the presence of wound edges is sufficient to cause activation of the EGF receptor and increased motility of cells in the absence of other cues. + + + + 20462956 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 14 + 0 + + + + + + + 18 + Data show that inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression. + + + + 20462955 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 14 + 0 + + + + + + + 18 + Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR. + + + + 20937808 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 14 + 0 + + + + + + + 18 + elevated plasma levels of epidermal growth factor receptor are associated with breast cancer among hormone therapy users. + + + + 20959476 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 11 + 14 + 0 + + + + + + + 18 + Activating epidermal growth factor receptor mutations are associated with response to gefitinib in non-small cell lung cancer. + + + + 20686428 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 54 + 0 + + + + + + + 18 + Expression of EGFR pathway components does not appear to have prognostic impact in surgically treated early-stage cervical cancer. + + + + 21078436 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 42 + 0 + + + + + + + 18 + Overexpression of EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF. + + + + 20978205 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 42 + 0 + + + + + + + 18 + EGFR mutation is associated with high chemotherapy response rate of non-small cell lung cancer. + + + + 20631634 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 42 + 0 + + + + + + + 18 + The c.2235-2249 (pGlu746-Ala750del) mutation in exon 19 was found in 2 patients with lung adenocarcinoma. 26% of the NSCLC cases overexpression EGFR had reduced PTEN and increased Mcl-1 expression. + + + + 19763916 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 28 + 0 + + + + + + + 18 + the gene expression profiles of lung adenocarcinoma are linked to histopathological grading and survival but not to EGF-R status + + + + 20196851 + + + + + + + + 2011 + 1 + 1 + 10 + 1 + 0 + + + + + + + + + 2011 + 1 + 1 + 10 + 11 + 0 + + + + + + + 18 + Overexpression and activation of epidermal growth factor receptor is associated with hemangioblastomas. + + + + 20730556 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 11 + 15 + 0 + + + + + + + 18 + We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage but also discovered two novel EGFR truncations. + + + + 20873989 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 11 + 11 + 0 + + + + + + + 18 + EGFR mutations did not correlate with pAkt and pERK expression in lung adenocarcinoma. + + + + 20117855 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 11 + 5 + 0 + + + + + + + 18 + EGFR expression is a common feature in MPM patients. High pre-treatment levels of serum EGFR are associated with advanced stage but not with reduced OS. + + + + 20347505 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 57 + 0 + + + + + + + 18 + Data report that Met protein expression and phosphorylation were associated with primary resistance to EGFR TKI therapy in NSCLC patients harboring EGFR mutations, implicating Met as a de novo mechanism of resistance. + + + + 20489150 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 54 + 0 + + + + + + + 18 + Mutation in the epidermal growth factor receptor gene confers sensitivity to the EGFR tyrosine kinase inhibitors in leptomeningeal metastases. + + + + 20146086 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 45 + 0 + + + + + + + 18 + Type I Ishikawa H and type II Hec50co endometrial carcinoma cells both express EGFR and sEGFR, but differ markedly in their responsiveness to the EGFR inhibitor gefitinib + + + + 20579378 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 23 + 0 + + + + + + + 18 + Demonstrate a chip capillary electrophoresis (chipCE) application for EGFR mutation detection by a combination of fragment analysis and denaturing CE along with multiplex ligation-dependent probe amplification (MLPA) for evaluation of EGFR amplification. + + + + 20967766 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 23 + 0 + + + + + + + 18 + EML4-ALK fusion gene was present at a high frequency in Chinese NSCLC patients, particularly in those with adenocarcinomas lacking EGFR/KRAS mutations + + + + 20624322 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 17 + 0 + + + + + + + 18 + The synergism deriving from EGFR and ErbB-2 blockade is mediated by alterations in signal transduction and in the expression of cell cycle regulatory proteins, including transcriptional and posttranscriptional regulation of p27(kip1) expression. + + + + 19946741 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 8 + 0 + + + + + + + 18 + EGFR-activating mutations were not present in the Japanese breast cancer series studied here. + + + + 21036744 + + + + + + + + 2010 + 12 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 11 + 10 + 8 + 0 + + + + + + + 18 + Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. + + + + 20826789 + + + + + + + + 2010 + 12 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 12 + 4 + 10 + 56 + 0 + + + + + + + 18 + Somatic epidermal growth factor gene point mutation is associated with Good clinical response to gefitinib in non-small cell lung cancer. + + + + 20522446 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 11 + 9 + 0 + + + + + + + 18 + These results suggest that linkage between ligand-induced dimerization and tyrosine kinase activation in the epidermal growth factor receptor is much looser than was previously envisioned. + + + + 20837704 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 11 + 8 + 0 + + + + + + + 18 + A potential role the nuclear EGFR may play in tumor response to radiation, chemotherapy, and EGFR-targeted therapy, is reviewed. + + + + 20670598 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 11 + 0 + 0 + + + + + + + 18 + EGFR gene mutations are associated with lung adenocarcinomas with features of the non-mucinous subtype of bronchioloalveolar carcinoma. + + + + 20661086 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 11 + 0 + 0 + + + + + + + 18 + These results propose a novel regulatory mechanism for the abnormal expression of Aurora-A in EGFR-overexpressed cancers. + + + + 19799648 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 59 + 0 + + + + + + + 18 + Gefitinib and Erlotinib induce responses in over 70% of non-small cell lung carcinoma patients harboring EGFR mutations, with progression-free survival. + + + + 20973798 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 45 + 0 + + + + + + + 18 + Data show that the ACK1 S985 N mutant is unable to bind ubiquitin, which contributes to ACK1 protein stability and stabilizes EGFR after EGF stimulation, thereby prolonging mitogenic signaling in cancer cells. + + + + 20359967 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 34 + 0 + + + + + + + 18 + 528scFv-TRAIL may have a role in treatment of EGFR-expressing cancers + + + + 20372797 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 34 + 0 + + + + + + + 18 + Multiple basolateral pathways mediate EGF receptor sorting in renal epithelial cells. + + + + 20519437 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 25 + 0 + + + + + + + 18 + EGFR gene mutations are not associated with non-small cell lung cancer. + + + + 20559151 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 25 + 0 + + + + + + + 18 + EGFR mutations are associated with lung adenocarcinomas. + + + + 20559149 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 25 + 0 + + + + + + + 18 + EGFR mutations are associated with HLA-A2 in female patients with adenocarcinoma of the lung. + + + + 20548248 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 24 + 0 + + + + + + + 18 + EGFRvIVa and EGFRvIVb mutants that lack internal segments distal to the intracellular tyrosine kinase domain confer an oncogenic potential + + + + 20676128 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 12 + 0 + + + + + + + 18 + Data show that EGFR mutations in exon 19 or 21 are associated with low exposure to cigarette smoke, whereas EGFR mutation in exon 20 is more common in smokers. + + + + 20237940 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 9 + 0 + + + + + + + 18 + Studies indicate that both fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating skeleton developments and grows pathways. + + + + 20564212 + + + + + + + + 2010 + 11 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 27 + 10 + 9 + 0 + + + + + + + 18 + This study is, to our knowledge, the first to perform a comprehensive tagging of the EGF and EGFR genes in glioblastoma + + + + 20197289 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 11 + 3 + 0 + + + + + + + 18 + GRP promotes the growth of HepG2 cells through interaction with GRPR co-expressed in tumor cells, and subsequently activates MAPK/ERK1/2 via EGFR-independent mechanisms. + + + + 20596631 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 10 + 56 + 0 + + + + + + + 18 + This data suggests the important role of GPR30/EGFR receptor signaling in the development of tamoxifen resistance + + + + 19911269 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 10 + 24 + 0 + + + + + + + 18 + cystic carcinomas of the breast have low Topo IIalpha expression but frequently overexpress EGFR protein without EGFR gene amplification. + + + + 20688355 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 10 + 24 + 0 + + + + + + + 18 + Primary glioblastomas with and without EGFR amplification did not show any significant differences in average survival + + + + 20051017 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 10 + 20 + 0 + + + + + + + 18 + EGFR and MAPK are actively involved in the pathobiology of serous cystic neoplasms of the pancreas. + + + + 20495538 + + + + + + + + 2010 + 11 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 13 + 10 + 16 + 0 + + + + + + + 18 + Protein kinase C (PKC)zeta is a novel mitogenic downstream mediator of epidermal growth factor (EGF) receptor, and a therapeutic target as well, in some carcinomas. + + + + 20407013 + + + + + + + + 2010 + 11 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 6 + 11 + 6 + 0 + + + + + + + 18 + the ratio of ErbB1 and ErbB2 in their heterocluster + + + + 20655838 + + + + + + + + 2010 + 11 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 11 + 6 + 11 + 0 + 0 + + + + + + + 18 + EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance + + + + 19859802 + + + + + + + + 2010 + 10 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 30 + 11 + 14 + 0 + + + + + + + 18 + observed a positive correlation of the nuclear expression of EGFR, RNA helicase A, and cyclin D1 in human breast cancer samples + + + + 20802156 + + + + + + + + 2010 + 10 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 30 + 11 + 14 + 0 + + + + + + + 18 + EGFR overexpression is associated with advanced colorectal adenomas. Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression. + + + + 20622650 + + + + + + + + 2010 + 10 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 30 + 11 + 1 + 0 + + + + + + + 18 + EGFRvIII mRNA can be detected in the serum of hepatocellular carcinoma patients. + + + + 20408943 + + + + + + + + 2010 + 10 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 30 + 10 + 43 + 0 + + + + + + + 18 + Akt has a pivotal role in EGFR-mediated cell migration + + + + 20562913 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 11 + 13 + 0 + + + + + + + 18 + nuclear transport of EGFR is regulated by COPI-mediated vesicular trafficking from the Golgi to the ER, and may serve as a general mechanism in regulating the nuclear transport of other cell surface receptors. + + + + 20674546 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 11 + 10 + 0 + + + + + + + 18 + EGFR mutations are associated with erlotinib at a dose of 25 mg daily for non-small cell lung cancers. + + + + 20512075 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 11 + 4 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with early stage of pulmonary adenocarcinoma development and tumor initiation from the preneoplastic lung parenchyma to neoplastic conditions. + + + + 20512074 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 11 + 4 + 0 + + + + + + + 18 + The inhibitory effect of the GHRH antagonist JMR-132 on proliferation is due, in part, to an interference with the EGFR-Akt pathway in ovarian cancer cells. + + + + 20509930 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 57 + 0 + + + + + + + 18 + EGFR and FCGR3A germline polymorphisms are associated with progression-free survival in KRAS wild-type metastatic colorectal cancer patients treated with cetuximab, bevacizumab and chemotherapy. + + + + 20418097 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 53 + 0 + + + + + + + 18 + EGFR phosphorylation is commonly encountered in breast carcinomas + + + + 20607659 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 43 + 0 + + + + + + + 18 + Signaling by the neuregulin-1beta/ErbB pathway regulates the ratio of sinoatrial node- to working-type cardiomyocytes in differentiating embryonic stem cell cultures and presumably functions similarly during early human heart development. + + + + 20671236 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 43 + 0 + + + + + + + 18 + Mutation of Thr654, located within the putative EGFR NLS demonstrated that phosphorylation of this residue is essential for nuclear EGFR shuttling following irradiation. + + + + 20692258 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 43 + 0 + + + + + + + 18 + EGFR and Her-2 may not have a role in oral squamous cell carcinoma, but there are low levels of EGF in saliva during disease progression + + + + 20429940 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 23 + 0 + + + + + + + 18 + The expression of EGFR increased after each surgical procedure. However it was lower after CO(2) pneumoperitoneum than after laparotomy. + + + + 20041268 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 14 + 0 + + + + + + + 18 + findings define a novel interaction between EGFR and Notch pathways in the adult subventricular zone, and thus provide a mechanism for neural stem cell and neural progenitor cell pool maintenance + + + + 20844536 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 13 + 0 + + + + + + + 18 + EGFRvIII with ErbB-2 enhances tumorigenesis + + + + 18787418 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 13 + 0 + + + + + + + 18 + A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR. + + + + 20540809 + + + + + + + + 2010 + 10 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 10 + 23 + 10 + 4 + 0 + + + + + + + 18 + These results indicate that imbalance alterations at several chromosomal regions occur significantly more frequently in lung adenocarcinomas with EGFR mutations than in those without such mutations. + + + + 20409020 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 52 + 0 + + + + + + + 18 + Theaflavins decreased the level of EGFR and inhibited the activation of EGFR, and attenuated airway mucous hypersecretion via the ERK pathway. + + + + 19484958 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 52 + 0 + + + + + + + 18 + SH3GL2 participates in the regulation of apoptosis through the MEK-ERK signal pathway by adjusting EGFR in the laryngeal carcinoma cell line Hep2 + + + + 20512084 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 40 + 0 + + + + + + + 18 + PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. + + + + 20554524 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 24 + 0 + + + + + + + 18 + results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-alpha + + + + 20622897 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 24 + 0 + + + + + + + 18 + SCCA, EGFR and cyclin D1 may prove to be useful tumor markers in oral squamous cell carcinoma. + + + + 20586028 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 12 + 24 + 0 + + + + + + + 18 + The length of the EGFR intron 1 CA repeats does not correlate with levels of EGFR expression and cannot be used as marker of clinical prognosis in pancreatic cancer patients. + + + + 20409526 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 11 + 40 + 0 + + + + + + + 18 + Data suggest implications of future therapeutic targets development for EGFRvIII-positive glioblastoma patients. + + + + 20461251 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 11 + 40 + 0 + + + + + + + 18 + Results suggest that the transactivation circuit acts as a context-dependent integrator and amplifier of multiple extracellular signals and that signal integration can effectively occur at multiple points in the EGFR pathway. + + + + 20458382 + + + + + + + + 2010 + 10 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 10 + 4 + 11 + 28 + 0 + + + + + + + 18 + Pgrmc1 associates with epidermal growth factor receptor and regulates erlotinib sensitivity + + + + 20538600 + + + + + + + + 2010 + 9 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 27 + 11 + 29 + 0 + + + + + + + 18 + EGF receptor activation drives cellular processes linked to ovarian tumor development, tumor cell survival, and metastasis. Review. + + + + 19763438 + + + + + + + + 2010 + 9 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 9 + 20 + 11 + 53 + 0 + + + + + + + 18 + EGFR signaling blockade or EGFR knockdown attenuated TGF-beta1-induced PAI-1 expression, implicating EGFR transactivation in TGF-beta1-stimulated PAI-1 expression + + + + 20428185 + + + + + + + + 2010 + 9 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 9 + 20 + 11 + 38 + 0 + + + + + + + 18 + Gefitinib may be considered as an upfront treatment option for EGFR-mutated NSCLC. + + + + 20502057 + + + + + + + + 2010 + 9 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 9 + 20 + 11 + 5 + 0 + + + + + + + 18 + Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. + + + + 20473902 + + + + + + + + 2010 + 9 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 9 + 20 + 11 + 5 + 0 + + + + + + + 18 + Collagen-embedded HA (eHA) inhibits EGFR activation, filopodia formation and cell spreading on a collagen matrix. + + + + 20009574 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 12 + 8 + 0 + + + + + + + 18 + EGFR activated AKT and inactivated GSK3beta + + + + 20734923 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 51 + 0 + + + + + + + 18 + The EGFRvIII-dependent glioblastoma multiforme cell transformation is associated with the onset of the simultaneous overexpression of tissue factor, protease-activated receptors 1 and 2, and ectopic synthesis of factor VII. + + + + 20462964 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 24 + 0 + + + + + + + 18 + This research was carried out to determine if conjunctival squamous cell carcinoma harbors human papillomavirus DNA and is associated with activation of the EGFR signaling pathway. + + + + 20498858 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 17 + 0 + + + + + + + 18 + HB-EGF participate in transactivation of EGF receptor under oxidative stress. + + + + 20586269 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 17 + 0 + + + + + + + 18 + EGF receptor tyrosine phosphorylation in lung cancer cells is regulated by Neuromedin B receptors. + + + + 20388507 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 9 + 0 + + + + + + + 18 + Findings in the EGFR gene suggest that germline genetic variants of EGFR in neuroepithelial cancer stem cells may be involved in glioma development. + + + + 20446891 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 9 + 0 + + + + + + + 18 + Genetic and functional interactions between COMT and AKT1 may provide novel insights into pathogenesis of schizophrenia and other ErbB-associated human diseases such as cancer. + + + + 20520724 + + + + + + + + 2010 + 9 + 13 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 13 + 11 + 9 + 0 + + + + + + + 18 + ADAM8 and EGFR are overexpressed in non-small cell lung cancer. + + + + 18710625 + + + + + + + + 2010 + 9 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 6 + 12 + 5 + 0 + + + + + + + 18 + Propose that EGFR amplification is an important and frequent pathway in glioblastomas. + + + + 20305620 + + + + + + + + 2010 + 9 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 6 + 11 + 52 + 0 + + + + + + + 18 + The EGFR/ERK pathway is activated in high-grade MECs with aggressive behaviour. + + + + 20664595 + + + + + + + + 2010 + 9 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 6 + 11 + 41 + 0 + + + + + + + 18 + epidermal growth factor receptor is expressed in precancerous oral lesions + + + + 20570883 + + + + + + + + 2010 + 9 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 9 + 6 + 11 + 31 + 0 + + + + + + + 18 + the inhibition of amphiregulin expression, which impairs EGFR response to its exogenously available ligands, may represent an alternative anti-EGFR therapeutic strategy in breast cancer. + + + + 20651357 + + + + + + + + 2010 + 8 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 30 + 12 + 15 + 0 + + + + + + + 18 + SIRPalpha1 specifically affects the SHP-2/FAK/Grb2/Sos-1/MAPK activation loop to downmodulate EGFRvIII-mediated migration and transformation. + + + + 20473329 + + + + + + + + 2010 + 8 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 30 + 11 + 8 + 0 + + + + + + + 18 + Overexpression of EGFR and COX-2 may play an important role in the tumorgenesis, progression and malignancy of lung cancer. Detection of EGFR and COX-2 expression might be helpful to diagnosis and prognosis of lung cancer. + + + + 20673501 + + + + + + + + 2010 + 8 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 30 + 11 + 8 + 0 + + + + + + + 18 + The present data demonstrate that sLe(x), in association with EGFR, in normal human bronchail epithelial cells, is coordinate with repair. + + + + 20447077 + + + + + + + + 2010 + 8 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 30 + 11 + 8 + 0 + + + + + + + 18 + EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but protein expression was detected in the majority of the cases. EGFR amplification was seen in tonsil but not in anal canal carcinomas. + + + + 20459770 + + + + + + + + 2010 + 8 + 23 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 23 + 12 + 11 + 0 + + + + + + + 18 + Lapatinib, a dual tyrosine kinase inhibitor of EGFR and HER-2 receptors demonstrated antiangiogenic/antitumor effects in a lung cancer model. + + + + 20459769 + + + + + + + + 2010 + 8 + 23 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 23 + 12 + 11 + 0 + + + + + + + 18 + glutamate signaling mediated by AMPA receptor induces U-87MG human malignant glioblastoma cell line proliferation via EGFR-phospho-Akt pathway. + + + + 19997873 + + + + + + + + 2010 + 8 + 23 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 23 + 12 + 11 + 0 + + + + + + + 18 + Report the expression and drug targeting of the EGFR in cholangiocarcinoma cell lines. + + + + 20565817 + + + + + + + + 2010 + 8 + 23 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 23 + 11 + 58 + 0 + + + + + + + 18 + The expression of EGFR in ovarian cancer is related to angiogenesis and chemoresistance + + + + 19538870 + + + + + + + + 2010 + 8 + 23 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 23 + 11 + 44 + 0 + + + + + + + 18 + EGFR gene mutation and high EGFR expression is associated with salivary duct carcinoma. + + + + 20371674 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 47 + 0 + + + + + + + 18 + Mutations in EGFR is associated with lung adenocarcinoma. + + + + 20150826 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 41 + 0 + + + + + + + 18 + A novel mechanism for promoting cancer progression by alcohol is found by stimulating the epithelial-mesenchymal transition program in cancer cells via an epidermal growth factor receptor-Snai1 pathway. + + + + 19860811 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 16 + 0 + + + + + + + 18 + Mutations may predict the biological nature of pulmonary adenocarcinomas and facilitate new therapies. + + + + 20491778 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 11 + 0 + + + + + + + 18 + These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity. + + + + 20510673 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + 18 + High EGFR expression is associated with meningioma. + + + + 20509969 + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 16 + 11 + 2 + 0 + + + + + + + 18 + Data showed that 9 tumor samples had strong expression of P-Akt and 5/9 had P-MAPK, and none of them had EGFR expression. + + + + 19729990 + + + + + + + + 2010 + 8 + 9 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 9 + 11 + 52 + 0 + + + + + + + 18 + Elevated expression level of EGFR is associated with a low response to chemoradiation in rectal cancer. + + + + 20117921 + + + + + + + + 2010 + 8 + 9 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 9 + 11 + 52 + 0 + + + + + + + 18 + the EGFR gene polymorphism might be associated with presence of asymptomatic airway hyperresponsiveness in young allergic adults + + + + 20357714 + + + + + + + + 2010 + 8 + 9 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 9 + 11 + 29 + 0 + + + + + + + 18 + Cytological specimens are equally well suited for EGFR gene analyses and FISH analysis as histological specimens. At present, the value of EGFR-FISH analysis is limited by the lack of validated criteria for FISH positivity. + + + + 19859710 + + + + + + + + 2010 + 8 + 9 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 9 + 11 + 29 + 0 + + + + + + + 18 + It appears that an increase in EGFR/CEP7 ratio to cutoff point of 4.5 may distinguish between coexisting EGFR (FISH ratio of >5) or KRAS (FISH ratio of 2 to 5) mutations. + + + + 20381121 + + + + + + + + 2010 + 8 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 2 + 12 + 1 + 0 + + + + + + + 18 + The single-clone model indicates subsequent disease progression, whereas genetic alterations from mutations to wild-type EGFR are suggestive of second primary carcinoma in patients with adenocarcinomas with a bronchioloalveolar carcinoma component + + + + 20439191 + + + + + + + + 2010 + 8 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 2 + 12 + 0 + 0 + + + + + + + 18 + Alterations in the EGFR-PTEN signaling pathway are present in a third of prostate adenocarcinomas, particularly affecting the more advanced cases. + + + + 20208477 + + + + + + + + 2010 + 8 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 2 + 11 + 20 + 0 + + + + + + + 18 + EGFR mutations appear to occur in highly selected subgroups of lung cancer patients: adenocarcinomas with bronchiolo-alveolar carcinoma components and patients of the female gender. + + + + 17845757 + + + + + + + + 2010 + 8 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 2 + 11 + 4 + 0 + + + + + + + 18 + Protein expression and/or increased gene copy number of EGFR is common in colorectal carcinomas but unrelated to pathological features. + + + + 17845756 + + + + + + + + 2010 + 8 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 8 + 2 + 11 + 4 + 0 + + + + + + + 18 + Fatty acid-binding protein 5 and PPARbeta/delta are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth + + + + 20424164 + + + + + + + + 2010 + 7 + 26 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 26 + 12 + 13 + 0 + + + + + + + 18 + EGFR mutation was recognized in approximately 20% of patients with pulmonary pleomorphic carcinoma. + + + + 20107421 + + + + + + + + 2010 + 7 + 26 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 26 + 11 + 58 + 0 + + + + + + + 18 + Results suggest that the expression of c-erbB-2 and EGF protein, but not necessarily ERG receptors, can help predict the postoperative survival time in stomach cancer. + + + + 20430735 + + + + + + + + 2010 + 7 + 26 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 26 + 11 + 50 + 0 + + + + + + + 18 + Clathrin-dependent endocytosis of EGFR is regulated by four mechanisms involving ubiquitination of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein, and the acetylation of three C-terminal lysine residues. + + + + 20513767 + + + + + + + + 2010 + 7 + 26 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 26 + 11 + 50 + 0 + + + + + + + 18 + EGFR tyrosine kinase domain mutations were not found in medullary thyroid carcinomas. EGFR polysomy & strong expression were seen in 15 & 13% of the tumors respectively. It was overexpressed in metastases. + + + + 19776290 + + + + + + + + 2010 + 7 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 19 + 12 + 9 + 0 + + + + + + + 18 + analysis of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors + + + + 20592359 + + + + + + + + 2010 + 7 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 19 + 11 + 38 + 0 + + + + + + + 18 + HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia. + + + + 20395290 + + + + + + + + 2010 + 7 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 19 + 11 + 28 + 0 + + + + + + + 18 + p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. + + + + 20453886 + + + + + + + + 2010 + 7 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 19 + 11 + 28 + 0 + + + + + + + 18 + Mutation in EGFR is associated with Neratinib response in non-small-cell lung cancer. + + + + 20479403 + + + + + + + + 2010 + 7 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 12 + 11 + 45 + 0 + + + + + + + 18 + Results showed a comparable rate of EGFR kinase domain mutations in lung adenocarcinomas from Chinese male and female never-smokers. + + + + 20418893 + + + + + + + + 2010 + 7 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 7 + 5 + 12 + 5 + 0 + + + + + + + 18 + although EGFR is expressed in most epithelioid sarcomas regardless of subtype, gene amplification and activating mutations in the tyrosine kinase domain appear to be rare or absent. + + + + 20118913 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 16 + 0 + + + + + + + 18 + High VEGFR2 expression, EGFR expression, and EGFR gene copy number were significantly correlated to triple-negative breast cancer + + + + 20135347 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 16 + 0 + + + + + + + 18 + EGFR -191C/A, -216G/T, and R497K polymorphisms are associated with diarrhea when using gefitinib in non small cell lung cancer patients. + + + + 20159991 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 15 + 0 + + + + + + + 18 + YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. + + + + 20224722 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 15 + 0 + + + + + + + 18 + Uveal melanomas express HGF, c-Met, EGFR, and IGF-1R + + + + 20061986 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 8 + 0 + + + + + + + 18 + These findings indicate the existence of the nuclear EGFR/EGFRvIII signaling pathway in GBM and its functional interaction with STAT3 to activate COX-2 gene expression. + + + + 20145033 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 8 + 0 + + + + + + + 18 + Mutations in TP53, KRAS, or EGFR are not major contributors to the RCC development even in the absence of VHL inactivation. + + + + 20137853 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 8 + 0 + + + + + + + 18 + The EGFR expression in the primary tumor and the corresponding metastasis is discordant in about 10% of the patients + + + + 20096104 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 7 + 0 + + + + + + + 18 + modulation of EGFR phosphorylation may explain how gangliosides contribute to regulate the lactogenic hormone-induced mammary cell differentiation + + + + 20156584 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 7 + 0 + + + + + + + 18 + The lack of positive correlation between EGFR protein expression and gene copy number suggests that mechanisms unrelated to gene amplification are involved in activating EGFR + + + + 20167476 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 7 + 0 + + + + + + + 18 + sulindac metabolite-induced downregulation of EGFR seems to be mediated through mechanism(s) similar, at least in part, to those involved in EGF-induced downregulation of EGFR. + + + + 20332299 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 12 + 6 + 0 + + + + + + + 18 + analysis of EGF receptor activation under the action of lipopolysaccharide on human A431 carcinoma cells + + + + 20506860 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 58 + 0 + + + + + + + 18 + data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation + + + + 20335174 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 42 + 0 + + + + + + + 18 + The EGF-receptor is mutated in a large variety of tumors. We review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Review. + + + + 20388509 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 42 + 0 + + + + + + + 18 + EGFR, HER-2 and HER-4 expression is not associated with poorer survival in neuroendocrine cancer + + + + 20204273 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 35 + 0 + + + + + + + 18 + Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. + + + + 19911255 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 26 + 0 + + + + + + + 18 + EGFR mutations do not appear to be a common event in upper aerodigestive tract carcinogenesis in this population + + + + 19955396 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 21 + 0 + + + + + + + 18 + The expression of EGFR and LRP could be used to predict chemotherapy resistance and prognosis of ovarian cancer. + + + + 19080004 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 16 + 0 + + + + + + + 18 + Stepwise COX regression analyses suggested that EGFR rs373506, rs759165 and rs6958497 may be independent candidate biomarkers to predict NSCLC survival in this population + + + + 20400478 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 7 + 0 + + + + + + + 18 + We confirmed the partial responsibility of p-Akt activation in invasion of some bladder cancer cell lines expressing N-cadherin or p-EGFR + + + + 19070520 + + + + + + + + 2010 + 6 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 28 + 11 + 3 + 0 + + + + + + + 18 + To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brain tumors, and to evaluate their prognostic significance. + + + + 17236582 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 20 + 0 + + + + + + + 18 + EGFR is a determinant of basaloid breast cancer. + + + + 19156550 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 13 + 0 + + + + + + + 18 + Phosphorylated EGFR appears to be a better indicator for lower disease-free survival than EGFR overexpression itself in localized non-small cell lung cancer. + + + + 19235531 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 12 + 0 + + + + + + + 18 + Hyaluronan can serve as a signal integrator by facilitating TGF-beta1-mediated CD44-EGF-R-ERK interactions and ultimately fibroblast phenotype. + + + + 20093489 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 9 + 0 + + + + + + + 18 + The affibody molecule (ZEGFR:955)2 gave no detectable autophosphorylation of EGFR but activated Erk and Akt. + + + + 20198342 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 9 + 0 + + + + + + + 18 + Data suggest that EGFR may be involved in a switch from stem to transient amplifying cell fate. + + + + 19799519 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 12 + 6 + 0 + + + + + + + 18 + Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. + + + + 20198339 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 43 + 0 + + + + + + + 18 + Have studied internalization of two EGFR-binding Affibody molecules: Z1907 (monovalent) and (Z1907)2 (bivalent) using fluorescence microscopy. + + + + 20198317 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 43 + 0 + + + + + + + 18 + The association of EGFR mutation status with patient characteristics and the SUV(MAX) from the [(18)F]FDG PET was evaluated + + + + 19130320 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 24 + 0 + + + + + + + 18 + EGFR sequence analysis was the only method useful for predicting response and progression-free survival following tyrosine kinase inhibitor therapy in non-small cell lung carcinoma. + + + + 20472851 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 23 + 0 + + + + + + + 18 + there was a trend toward an association between shorter overall survival time and epidermal growth factor receptor amplification as determined by fluorescence in situ hybridization analysis. + + + + 20303140 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 18 + 0 + + + + + + + 18 + The EGFR-mutated lung adenocarcinoma showed a significantly higher prevalence of past illness involving the gastric cancer in males or uterine myoma in females + + + + 19362747 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 16 + 0 + + + + + + + 18 + Ligand-independent but p38-dependent EGFR internalization process is involved in the control of keratinocyte physiology during stress conditions. + + + + 20039046 + + + + + + + + 2010 + 6 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 6 + 14 + 11 + 9 + 0 + + + + + + + 18 + Expression of epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues + + + + 19823871 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 12 + 9 + 0 + + + + + + + 18 + slow physical deformation of the lateral intercellular space in response to a step increase in loading leads to synchronous activation of the EGFR. + + + + 20056713 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 12 + 5 + 0 + + + + + + + 18 + EGFR signaling regulates beta-catenin localization and stability, target gene expression, and tumor progression in oral cancer. + + + + 20302655 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 12 + 5 + 0 + + + + + + + 18 + Downregulation of EGFR is associated with non-small cell lung cancer metastasis. + + + + 19687761 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 59 + 0 + + + + + + + 18 + In ovarian cancer cells highly responsive to lysophosphatidic acid (LPA), activation of AP-1 by LPA was suppressed by inhibition of EGFR while NF-kappaB was stimulated via the Gq-PKC pathway in an EGFR-independent manner. + + + + 20074357 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 55 + 0 + + + + + + + 18 + Bcl-2 and Bax, being nuclear matrix associated proteins, are probably involved in the EGFR-cDNA induced malignant conversion of glioblastoma cells by introducing EGFR cDNA into the tumor cells. + + + + 12839682 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 49 + 0 + + + + + + + 18 + The expression of EGF in lymph nodes was related to lymph node EGFR level. + + + + 20164030 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 48 + 0 + + + + + + + 18 + Subsets of patients with colon adenocarcinoma demonstrate specific protein/gene alterations regarding EGFR/VEGF/HIF1a molecules. + + + + 20414936 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 43 + 0 + + + + + + + 18 + EGFR signaling can regulate MET levels through HIF-1alpha and that MET is a key downstream mediator of EGFR-induced invasiveness in EGFR-dependent NSCLC cells. + + + + 20154724 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 37 + 0 + + + + + + + 18 + Non-small cell lung cancer harboring sensitizing EGFR Mutations are associated with osteoblastic responses during disease control by tyrosine kinase inhibitor treatment. + + + + 20186030 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 37 + 0 + + + + + + + 18 + Mutations in the epidermal growth factor receptor gene is associated with response to treatment with EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer. + + + + 20186026 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 37 + 0 + + + + + + + 18 + Nuclear EGFR correlated with shorter overall survival in whole cohort and in the premenopausal group of patients with ductal invasive breast cancer. + + + + 20062009 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 32 + 0 + + + + + + + 18 + Results highlight the role of TI-VAMP in the secretory pathway of a tetraspanin, and support a model in which CD82 allows EGFR entry in microdomains that control its clathrin-dependent endocytosis and signaling. + + + + 20144992 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 24 + 0 + + + + + + + 18 + activation of Pyk2 is an early signal that promotes wound healing by stimulating the SFK/EGFR signaling pathway. + + + + 20215112 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 24 + 0 + + + + + + + 18 + Overexpression of Egr-1 is caused by mutation of p53 and appears to be initiated through activation of the MEK/ERK1/2 signaling cascade by mutant p53. + + + + 20190820 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 24 + 0 + + + + + + + 18 + There might be a cross-talk of bi-directional control between Notch1 and EGFR signaling in regulating the cellular proliferation of human tongue squamous carcinoma cells. + + + + 20193370 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 24 + 0 + + + + + + + 18 + Vav2 can regulate growth factors receptor signalling by slowing receptor internalization and degradation through its interaction with endosome-associated proteins. + + + + 20140013 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 17 + 0 + + + + + + + 18 + Matrix-assisted laser desorption ionization remains a potent and highly clinically significant predictor of survival after first-line treatment with erlotinib in non-small-cell lung cancer patients with wild-type EGFR mutation. + + + + 20035238 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 17 + 0 + + + + + + + 18 + Aberrant methylation and alterations of EGFR signaling is associated with chronic obstructive pulmonary disease-related non-small cell lung cancer. + + + + 19841986 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 11 + 0 + + + + + + + 18 + Mig-6 controls EGFR trafficking and suppresses gliomagenesis + + + + 20351267 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 7 + 0 + + + + + + + 18 + dimers were enriched in the cell periphery in an actin- and receptor-expression-dependent fashion, resulting in a peripheral enhancement of EGF-induced signalling that may enable polarized responses to growth factors + + + + 20208517 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 7 + 0 + + + + + + + 18 + A high proportion of in situ SCCs already have increased EGFR gene copy numbers, but these alterations do not seem to play a role in the progression from low-grade SCCs into more aggressive phenotypes. + + + + 20156290 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 7 + 0 + + + + + + + 18 + No specific computed tomography appearance, which would correlate with either an EGFR mutation or a KRAS mutation was associated with adenocarcinoma of the lung with bronchioloalveolar features. + + + + 20087229 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 7 + 0 + + + + + + + 18 + The methods by which HER dimerization can be explored and the potential that this has in the treatment of breast cancer, is reviewed. + + + + 19925033 + + + + + + + + 2010 + 5 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 31 + 11 + 7 + 0 + + + + + + + 18 + Studies indicate that lapatinib - a tyrosine kinase inhibitor targets not only EGFR (erb B1) but also erb B2 (HER2) receptor tyrosine kinase signalling. + + + + 20030876 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 12 + 7 + 0 + + + + + + + 18 + microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation + + + + 20133936 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 11 + 38 + 0 + + + + + + + 18 + These data suggest that the rs884419 polymorphism flanking the EGFR gene is an independent prognostic genetic biomarker that predicts prostate cancer biochemical recurrence after radical prostatectomy. + + + + 20303520 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 11 + 34 + 0 + + + + + + + 18 + EGFR expression is different between primary nasopharygeal carcinoma and lymph node metastases. + + + + 19460717 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 11 + 21 + 0 + + + + + + + 18 + Human cytomegalovirus engages the epidermal growth factor receptor to facilitate upregulation of myeloid cell leukemia sequence (Mcl)-1 and acquisition of the apoptotic resistant phenotype in infected monocytes. + + + + 20173022 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 11 + 16 + 0 + + + + + + + 18 + Data show that a unique gene, KLHDC8, herein referred to as KLHDC8A/SDeltaE (Substitute for DeltaEGFR Expression)-1, is highly expressed in these tumors, which have escaped dependence on DeltaEGFR. + + + + 20133782 + + + + + + + + 2010 + 5 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 10 + 11 + 16 + 0 + + + + + + + 18 + HtrA1 has a role in promoting anoikis by attenuating activation of EGFR/AKT pathway that may contribute to its metastasis suppression capacity + + + + 20388781 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 15 + 0 + + + + + + + 18 + Heterozygosity status of 1p and 19q and its correlation with p53 protein expression and EGFR amplification in patients with astrocytic tumors. + + + + 20362227 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 14 + 0 + + + + + + + 18 + Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8. + + + + 20064931 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 9 + 0 + + + + + + + 18 + In Chinese patients with CRC, EGFR mutations were rare, and K-ras mutations were similar to those of Europeans. + + + + 20184776 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 9 + 0 + + + + + + + 18 + Features of KRAS mutations in lung cancer and contrast these with the features of EGFR mutations. + + + + 20108024 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 9 + 0 + + + + + + + 18 + Additional role of chemotherapy and the management of tumours with the secondary T790M mutation that confers resistance to EGFR TKIs. + + + + 20156777 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 9 + 0 + + + + + + + 18 + Overexpression of EGFR pathway-related genes in the circulation is highly correlated with EGFR mutations and overexpression in paired cancer tissue from patients with non-small cell lung cancer. + + + + 20127001 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 12 + 9 + 0 + + + + + + + 18 + Phosphorylation of EGFR is related with metastasis-free survival of nasopharyngeal carcinoma patients. + + + + 18479591 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 59 + 0 + + + + + + + 18 + EGFR and KRAS mutations were found in 33 (10%) and 78 (23%) of lung adenocarcinomas, respectively, whereas 226 (67%) cases were negative for both mutations + + + + 19855375 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 49 + 0 + + + + + + + 18 + two novel and important functions of CX3CL1 on primary human vascular smooth muscle: anti-apoptosis and proliferation, both mediated via epiregulin-induced EGFR signalling + + + + 19840952 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 42 + 0 + + + + + + + 18 + Expression of p27 was positively correlated with the expression of EGFR and GST-pi, while the expression of EGFR was significantly associated with the expression of p21 + + + + 19923826 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 41 + 0 + + + + + + + 18 + results suggest the majority of gain-of-function mutations within kinase genes in the EGFR signaling pathway have already been identified. Our findings also implicate FGFR4 in the pathogenesis of a subset of lung adenocarcinomas + + + + 17487277 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 41 + 0 + + + + + + + 18 + Studies indicate communication between tumor cells and their microenvironment is through polypeptide growth factors EGF, FGF, PDGF and receptors for these growth factors. + + + + 20036812 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 23 + 0 + + + + + + + 18 + Results suggest that the EGFR SNP at codon 787 of exon 20 determined in pretreatment biopsy specimens may be a clinically useful biomarker for predicting the prognosis of ESCC patients. + + + + 20036807 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 23 + 0 + + + + + + + 18 + data identify an elevated frequency of EGFR gene amplification and EGFRvIII mutation in pediatric high-grade glioma than previously recognized + + + + 19737945 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 19 + 0 + + + + + + + 18 + Stage IV NSCLC patients with mutated EGFR had a longer progression-free survival after the front-line chemotherapy. + + + + 19477549 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 18 + 0 + + + + + + + 18 + COX-2, EGFR and VEGF are overexpressed in gastric carcinoma. Helicobacter pylori infection may upregulate the expression of COX-2 and EGFR in gastric cancer tissues. + + + + 19173907 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 7 + 0 + + + + + + + 18 + Overview of the current understanding of the lung adenocarcinoma subset harboring EGFR mutations with special reference to the molecular classification of lung cancer and the novel concept of the "terminal respiratory unit." + + + + 20135199 + + + + + + + + 2010 + 5 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 5 + 3 + 11 + 7 + 0 + + + + + + + 18 + The results demonstrated the presence of intratumor molecular heterogeneity for the clinically relevant EGFR mutated alleles in these early-stage lung tumors + + + + 20207772 + + + + + + + + 2010 + 4 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 19 + 11 + 38 + 0 + + + + + + + 18 + Our study revealed an influence of the EGFR-R521K genotype on skin toxicity and suggested its relation to clinical activity of cetuximab/docetaxel treatment. + + + + 20028750 + + + + + + + + 2010 + 4 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 19 + 11 + 33 + 0 + + + + + + + 18 + EGFR-PTP1B interaction occurs by means of direct membrane contacts between the perimeter membrane of multivesicular bodies (MVB) and the endoplasmic reticulum. PTP1B activity promotes the sequestration of EGFR on to MVB internal vesicles. + + + + 20118922 + + + + + + + + 2010 + 4 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 19 + 11 + 29 + 0 + + + + + + + 18 + Autophagy promoted via troglitazone is correlated with AMPKalpha activation and independent of PPARgamma activation and EGFR transactivation. + + + + 19923924 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 34 + 0 + + + + + + + 18 + The p53 protein expression was higher in a group of adenocarcinomas having the EGFR L858R mutation than in that of adenocarcinomas with EGFR mutation in exon 19. + + + + 20131498 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 23 + 0 + + + + + + + 18 + These results indicate that PXK plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor. + + + + 20086096 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 23 + 0 + + + + + + + 18 + These findings suggest an essential role of Nedd4-1 in regulation of EGFR degradation through interaction with and ubiquitination of ACK. + + + + 20086093 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 23 + 0 + + + + + + + 18 + TGFbeta(1) activates EGFR via an H(2)O(2)-dependent mechanism, which subsequently leads to the activation of Erk(1/2). + + + + 19751964 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 17 + 0 + + + + + + + 18 + Activation of the epidermal growth factor receptor (EGFR) pathway emerges as a resistance mechanism in MET-amplified cells after prolonged exposure to PF2341066. + + + + 20124471 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 17 + 0 + + + + + + + 18 + ErbB/PI3K/Akt/NF-kappaB signalling in the progression of prostate cancer + + + + 20216540 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 17 + 0 + + + + + + + 18 + EGFR is moderately or strongly overexpressed on the cell membrane most adenocarcinomas of the biliary tree and has an adverse impact on prognosis. Gain of EGFR gene copy number is present in approximately half of cases. + + + + 20040392 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 7 + 0 + + + + + + + 18 + These findings demonstrate that hypoxia activates EGFR tyrosine kinase, leading to arginase expression and thereby promoting proliferation in human pulmonary microvascular endothelial cell. + + + + 20139181 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 7 + 0 + + + + + + + 18 + Antisense-miR-21-treated human gliobalstoma cells showed a decreased expression of EGFR(epidermal growth factor receptor) + + + + 20048743 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 12 + 7 + 0 + + + + + + + 18 + Our results underscore the divergent mechanisms underlying the tumorigenesis of periocular and extraocular sebaceous carcinoma and suggest an association between aggressive behavior and increased EGFR expression in extraocular sebaceous carcinoma. + + + + 19614729 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 11 + 38 + 0 + + + + + + + 18 + E5 and the EGF-receptor cooperate to enhance cell cycle entry and progression through regulating p27(Kip1) expression at protein level. + + + + 20144468 + + + + + + + + 2010 + 4 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 4 + 12 + 11 + 37 + 0 + + + + + + + 18 + depletion of p38alpha MAP kinase activity suppresses EGF receptor signaling and downstream Erk MAP kinase signaling, as well as autocrine EGF receptor-dependent proliferation. + + + + 20188673 + + + + + + + + 2010 + 3 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 29 + 11 + 50 + 0 + + + + + + + 18 + These results provide a plausible mechanism for EGFRvIII-mediated invasion and establish a functional link between EGFRvIII and CXCR4 signaling pathways. + + + + 19830694 + + + + + + + + 2010 + 3 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 29 + 11 + 43 + 0 + + + + + + + 18 + These data describe a novel mechanism of cross-talk between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and growth-inhibiting signaling pathways. + + + + 19864455 + + + + + + + + 2010 + 3 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 29 + 11 + 22 + 0 + + + + + + + 18 + epidermal growth factor receptor (EGFR) has a role in head and neck cancer and its response to treatment [review] + + + + 16722544 + + + + + + + + 2010 + 3 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 29 + 11 + 20 + 0 + + + + + + + 18 + EGFR mutations are associated with lung adenocarcinomas. + + + + 19875972 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 56 + 0 + + + + + + + 18 + Erlotinib therapy for pretreated patients with EGFR-wt tumors seems to have a modest activity with no irreversible toxicity. + + + + 19898258 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 56 + 0 + + + + + + + 18 + the EGFR pathway is critical for the upregulation of keratinocyte GM-CSF expression under conditions of cytokine stimulation + + + + 19890352 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 56 + 0 + + + + + + + 18 + genetic activation of EGFR by mutation or amplification is in a small subset of cutaneous squamous cell carcinoma + + + + 19812598 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 14 + 0 + + + + + + + 18 + A relationship between high levels of EGFR and HER-2 in the tumors of patients with esophageal squamous-cell carcinoma and intravascular tumor invasion and poor outcome of the disease was detected. + + + + 20027338 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 7 + 0 + + + + + + + 18 + PAR-2-mediated sVEGFR-1 release depended on protein kinase C-beta(1) and protein kinase C-epsilon, which required intracellular transactivation of epidermal growth factor receptor 1 in endothelial cells + + + + 20124108 + + + + + + + + 2010 + 3 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 22 + 11 + 7 + 0 + + + + + + + 18 + Caveolin-1 overexpression in MCF-7 breast cancer cell line modulates EGFR activation levels and EGF-induced EGFR signalling. + + + + 19483462 + + + + + + + + 2010 + 3 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 15 + 12 + 29 + 0 + + + + + + + 18 + Findings offer a mechanistic explanation for the limited efficacy of irreversible EGFR inhibitors in EGFR(T790M) gatekeeper-mutant tumors. + + + + 20103621 + + + + + + + + 2010 + 3 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 15 + 11 + 55 + 0 + + + + + + + 18 + EGFR may have a role in progression of cervical cancer + + + + 19920104 + + + + + + + + 2010 + 3 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 15 + 11 + 36 + 0 + + + + + + + 18 + EGFR T790M mutation and c-MET amplification can occur in tyrosine kinase inhibitor-resistant non-small cell lung cancer with wild-type EGFR. These genetic defects might be related to different survival outcome. + + + + 19381876 + + + + + + + + 2010 + 3 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 15 + 11 + 34 + 0 + + + + + + + 18 + simultaneous detection of p53, Rb, p16, and EGFR in a suspension microarray facilitates rapid diagnosis of lung cancer + + + + 20082263 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 33 + 0 + + + + + + + 18 + Decrease in extracellular domains of EGFR after surgery is associated with breast cancer progression. + + + + 20044624 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 33 + 0 + + + + + + + 18 + EGFR mutational status was associated with clinical response in non-small cell lung cancer. + + + + 19884861 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 11 + 0 + + + + + + + 18 + epidermal growth factor receptor mutation-positive recurrent non-small cell lung cancer is associated with dramatic response to low-dose erlotinib. + + + + 20009914 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 11 + 0 + + + + + + + 18 + Mutant dimers showed less stability than wild type EGFR dimer. + + + + 20049516 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 4 + 0 + + + + + + + 18 + Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively of glioblastoma multiforme + + + + 20129251 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 4 + 0 + + + + + + + 18 + EGFR and HPV demonstrate a significant correlation with genesis and progression of cervical carcinoma. + + + + 18396688 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 12 + 3 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation is associated with pathologic-radiologic correlation between multiple lung nodules with ground-glass opacity differentiates multicentric origin from intrapulmonary spread. + + + + 19844187 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 11 + 36 + 0 + + + + + + + 18 + EGFR gene numerical alterations -although rare- and also chromosome 7 aneuploidy maybe affect prognosis in hepatocellular carcinomas + + + + 19145479 + + + + + + + + 2010 + 3 + 8 + 11 + 3 + 0 + + + + + + + + + 2010 + 3 + 8 + 11 + 12 + 0 + + + + + + + 18 + plasma membrane distribution of the P2Y(2)R is transregulated by the epidermal growth factor receptor + + + + 19996104 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 59 + 0 + + + + + + + 18 + The study demonstrates a novel role of TK in skin wound healing uncovering new signaling pathway mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation. + + + + 19879874 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 19 + 0 + + + + + + + 18 + Adhesion-induced EphA2 expression is dependent upon activation of the epidermal growth factor receptor (EGFR), mitogen activated protein kinase kinase (MEK) and Src family kinases (SRC). + + + + 19948216 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 19 + 0 + + + + + + + 18 + analysis of the effect of inhibitors (the chimeric 225 antibody and tyrosine phosphorylation inhibitor AG1478) on the nanoscale clustering of EGFR in HeLa cells + + + + 19959837 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 19 + 0 + + + + + + + 18 + combing activating KRAS mutants and EGFR could help to identify the subgroup of patients who are most likely to respond to cetuximab plus chemotherapy + + + + 20010090 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 13 + 0 + + + + + + + 18 + Data show that the activities of EGFR-MAPK signal pathway were inhibited significantly by overexpression of cav1. + + + + 19893453 + + + + + + + + 2010 + 3 + 1 + 11 + 2 + 0 + + + + + + + + + 2010 + 3 + 1 + 11 + 3 + 0 + + + + + + + 18 + EGFR plays an essential role in the immunopathobiology of HCMV by mediating viral entry into monocytes and stimulating the aberrant biological activity that promotes hematogenous dissemination. + + + + 20018733 + + + + + + + + 2010 + 2 + 22 + 11 + 3 + 0 + + + + + + + + + 2010 + 2 + 22 + 12 + 26 + 0 + + + + + + + 18 + Data show that overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor/HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization. + + + + 19515834 + + + + + + + + 2010 + 2 + 22 + 11 + 3 + 0 + + + + + + + + + 2010 + 2 + 22 + 12 + 3 + 0 + + + + + + + 18 + In the Ecuadorian population, L858R and G719S mutations are mainly found in NSCLC, in women, nonsmokers, and individuals with adenocarcinoma + + + + 20082861 + + + + + + + + 2010 + 2 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 15 + 12 + 7 + 0 + + + + + + + 18 + Taken together, we provide evidence that AREG stimulation of EGFR results in high levels of PTHrP gene expression, contributing to cancer-associated bone pathology. + + + + 19825997 + + + + + + + + 2010 + 2 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 15 + 12 + 0 + 0 + + + + + + + 18 + The T790M EGFR mutation was found by pyrosequencing, and this seemed to be the cause of drug resistance. Resistant cells also showed MET activation, although gene amplification was not detected. + + + + 19808904 + + + + + + + + 2010 + 2 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 15 + 11 + 5 + 0 + + + + + + + 18 + Studies indicate that capsaicin is a novel modulator of the EGFR/HER-2 pathway in both ER-positive and -negative breast cancer cells with a potential role in the treatment and prevention of human breast cancer. + + + + 19855437 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 48 + 0 + + + + + + + 18 + Discovery of EGFR, the EGFR signal transduction pathway and mutations of the EGFR gene in lung cancers and glioblastomas. Review. + + + + 19922469 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 45 + 0 + + + + + + + 18 + Elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer. + + + + 19917135 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 43 + 0 + + + + + + + 18 + EGFR/KRAS mutation testing of multiple lung adenocarcinomas can assist in differentiating multiple primary lung adenocarcinomas from metastatic lesions. + + + + 19376842 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 17 + 0 + + + + + + + 18 + temporal regulation of EGFR endocytosis is achieved by auto-regulatory PLD1 which senses the receptor activation and triggers the translocation of AP2 near to the activated receptor + + + + 19763255 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 17 + 0 + + + + + + + 18 + Notch3 not only has a crucial role in lung cancer through regulating apoptosis, but also cooperates with the EGFR-MAPK pathway in modulating Bim. + + + + 19881544 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 16 + 0 + + + + + + + 18 + SNP HER2 I655V, but not the EGFR R497K, was associated with thyroid cancer risk. + + + + 19860576 + + + + + + + + 2010 + 2 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 2 + 8 + 11 + 16 + 0 + + + + + + + 18 + show that EFEMP1 binds EGF receptor (EGFR) in a competitive manner relative to epidermal growth factor (EGF), implicating that EFEMP1 and EGF share the same or adjacent binding sites on the EGFR. + + + + 19804359 + + + + + + + + 2010 + 2 + 1 + 11 + 3 + 0 + + + + + + + + + 2010 + 2 + 1 + 11 + 35 + 0 + + + + + + + 18 + The Egfr+2073 A/T polymorphism is not associated with an increased risk of endometriosis in a Japanese population. + + + + 17852426 + + + + + + + + 2010 + 2 + 1 + 11 + 3 + 0 + + + + + + + + + 2010 + 2 + 1 + 11 + 9 + 0 + + + + + + + 18 + Four genes, PCSK1, (P=0.008), EGFR,(P=0.003), PAX4,(P=0.008), and LYN,(P=0.002) consistently yielded statistical evidence for association with longevity. + + + + 19641380 + + + + + + + + 2010 + 2 + 1 + 11 + 3 + 0 + + + + + + + + + 2010 + 2 + 1 + 11 + 8 + 0 + + + + + + + 18 + (1)R-epidermal growth factor receptor crosstalk may be a key interaction that maintains tumor growth + + + + 19184415 + + + + + + + + 2010 + 1 + 25 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 25 + 11 + 47 + 0 + + + + + + + 18 + EGFR mutation analysis for 1,176 NSCLC patients showed mutation was significantly associated with adenocarcinoma & light-smoking, but not gender. Exon 19 deletions were more frequent in males while exon 21 deletions were more frequent in females. + + + + 19609951 + + + + + + + + 2010 + 1 + 25 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 25 + 11 + 47 + 0 + + + + + + + 18 + In analyzing exons 18-21 of EGFR in 96 patients with SCCHN, only one SNP was found in the 78th site of exon 20 and it mostly existed in specimens coming from the hypopharynx. + + + + 19863329 + + + + + + + + 2010 + 1 + 25 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 25 + 11 + 38 + 0 + + + + + + + 18 + EGFR expression in RCC was mostly located in the cell membrane, whereas the EGFR expression in normal renal tissues was chiefly seen in cytoplasm. Different locations of EGFR expression may be associated with human renal tumorigenesis. + + + + 19747398 + + + + + + + + 2010 + 1 + 25 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 25 + 11 + 28 + 0 + + + + + + + 18 + Data show that decorin specifically inhibits EGFR and AR phosphorylation and cross talk between these pathways in prostate cancer cells. + + + + 19794963 + + + + + + + + 2010 + 1 + 21 + 12 + 19 + 0 + + + + + + + + + 2010 + 1 + 21 + 13 + 4 + 0 + + + + + + + 18 + Molecular studies showed 3 (20%) of 15 oncocytic adenocarcinomas of lung with EGFR mutations and 3 additional cases with KRAS mutations. + + + + 20023269 + + + + + + + + 2010 + 1 + 21 + 12 + 19 + 0 + + + + + + + + + 2010 + 1 + 21 + 12 + 47 + 0 + + + + + + + 18 + These findings confirmed the importance of EGFR immunoexpression rate as well as IL-6 and TNFalpha secretion by peripheral blood mononuclear cells as potential biomarkers for assessing the aggressive tumor phenotype in laryngeal carcinoma. + + + + 19789511 + + + + + + + + 2010 + 1 + 21 + 12 + 19 + 0 + + + + + + + + + 2010 + 1 + 21 + 12 + 34 + 0 + + + + + + + 18 + study shows that mutant EGFRs in NSCLC cell lines are constitutively endocytosed as shown by their colocalization with the early/recycling endosomal marker transferrin and the late endosomal/lysosomal marker LAMP1. + + + + 19948031 + + + + + + + + 2010 + 1 + 21 + 12 + 19 + 0 + + + + + + + + + 2010 + 1 + 21 + 12 + 25 + 0 + + + + + + + 18 + Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 19956635 + + + + + + + + HuGENet + + + 1956.19956635 + + + + + HuGENet + + + + + + + 2010 + 1 + 20 + 21 + 34 + 0 + + + + + + + + + 2010 + 1 + 20 + 21 + 35 + 0 + + + + + + + 18 + EGFR is preferentially expressed by human bulge cells, compared to differentiated hair follicle keratinocytes + + + + 20050020 + + + + + + + + 2010 + 1 + 14 + 16 + 29 + 0 + + + + + + + + + 2010 + 1 + 15 + 9 + 25 + 0 + + + + + + + 18 + Diesel particle-induced transcriptional expression of p21 involves activation of EGFR, Src, and Stat3 + + + + 19329556 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + African American patients with non-small-cell lung cancer are significantly less likely than white counterparts to harbor activating mutations of EGFR. + + + + 19786660 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The relationship between COX-2 and EGFR in cancer cells, was investigted. + + + + 19671676 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CoxII can be phosphorylated by EGFR and c-Src, and EGF stimulation reduces Cox activity and cellular ATP, an event that is dependent in large part on EGFR localized to the mitochondria. + + + + 19840943 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + confluent p38alpha-deficient cells fail to downregulate Spry2, providing them in turn with sustained EGFR signaling that facilitates cell overgrowth and oncogenic transformation + + + + 19364817 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + miR-206 contributes to EGFR-mediated abrogation of estrogenic responses in MCF-7 cells, contributes to a Luminal-A- to Basal-like phenotypic switch, and may be a measure of EGFR response within Basal-like breast tumors + + + + 19423651 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Pathogenic L1-CAM mutations reduce the activation of EGFR. + + + + 19617634 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress + + + + 19789263 + + + + + + + + 2010 + 1 + 11 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients harboring sensitizing EGFR mutations should be considered for first-line erlotinib or gefitinib. + + + + 19671843 + + + + + + + + 2010 + 1 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of EGFRvIII in laryngeal carcinoma was confirmed in this study. It is tumor-specific and tends to be more frequent in EGFR-over expressing tumor tissues and poorly differentiated ones, which may in part contribute to the malignant phenotype. + + + + 19427146 + + + + + + + + 2010 + 1 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. + + + + 19820359 + + + + + + + + 2010 + 1 + 4 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + BRAF status, EGFR amplification, and cytoplasmic expression of PTEN were associated with outcome measures in KRAS wild-type patients treated with a cetuximab-based regimen. + + + + 19884556 + + + + + + + + 2009 + 12 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and KRAS status of primary lung carcinomas may not predict the status in the corresponding metastases. + + + + 19740513 + + + + + + + + 2009 + 12 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observed weak transactivation is uni-directional where stimulation of EGFR leads to HER3 activation whereas HER3 stimulation does not activate the EGFR. + + + + 19878579 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Phosphorylated EGFR without mutations may be a marker of poor prognosis in patients with head and neck squamous cell carcinoma + + + + 19726454 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + loss of CRMP1 contribute to the increased invasive phenotype of human Glioblastoma multiforme brain tumors expressing mutant EGFRvIII. + + + + 19903856 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High epidermal growth factor receptor expression is associated with second primary tumors of the upper aero-digestive tract. + + + + 19669840 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + suppression of Rab5A or 5B hampered the degradation of EGFR + + + + 19723633 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Based on extended survival time under severe conditions, we propose that positive EGFR double-activating somatic mutation may be a good prognostic factor + + + + 19963121 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation-induced cell death. + + + + 19787273 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that coordinated phosphorylation of EGFR involving sites Tyr(998), Ser(991), Ser(1039), and Thr(1041) governs the trafficking of EGF receptors. + + + + 19531499 + + + + + + + + 2009 + 12 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The endogenous levels of EGFR in erosive oral lichen planus was significantly higher than those in reticular OLP and normal oral mucosa. + + + + 16329825 + + + + + + + + 2009 + 12 + 14 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of the experssion of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma + + + + 19563658 + + + + + + + + 2009 + 12 + 14 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study confirmed an increase in EGFR protein expression and gene amplification with the increase in biological aggressiveness of glottic lesions + + + + 19673037 + + + + + + + + 2009 + 12 + 14 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. + + + + 19798056 + + + + + + + + 2009 + 12 + 14 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Estrogen receptor alpha and beta expression distinguishes a subset of NSCLC that has defined clinicopathologic and genetic features. In lung adenocarcinoma, estrogen receptor alpha expression correlates with EGFR mutations. + + + + 19706809 + + + + + + + + 2009 + 12 + 14 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High epidermal growth factor receptor expression is associated with metastatic colorectal cancer lymph nodes. + + + + 19451802 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings show that non-transformed and transformed prostate epithelial cells may employ different mechanisms to activate EGFR ligands and thereby utilize the EGFR axis to promote cellular proliferation + + + + 19735466 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell lines with EGFR 3'-UTR mutations were more sensitive to EGFR inhibition than EGFR 3'-UTR WT cells, suggesting that this mutation provides a growth advantage to this subset of MSI colon tumors. + + + + 19789347 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR protein overexpression and its tyrosine kinase domain mutations in areca quid-associated oral cavity squamous cell carcinoma + + + + 19360742 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + SHH and EGFR signal pathways are active in pancreatic carcinoma, and are closely correlated to cancer cell proliferation. SHH and EGFR expression were positively correlated to PCNA expression. + + + + 17927850 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Report EGFR-dependent and independent activation of Akt/mTOR/p70S6 kinase/4E-BP1 cascade in bone and soft tissue tumors. + + + + 19648884 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We performed EGFR mutation analysis in 307 NSCLC (exon 18-21). The data were analyzed for associations with clinical-pathological parameters. + + + + 19357847 + + + + + + + + 2009 + 12 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR amplification and exon 19 deletion mutations are associated with lung adenocarcinomas. + + + + 19826035 + + + + + + + + 2009 + 11 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings support the proposal that nuclear EGFR and cytoskeleton integrity play an important role in breast cancer. + + + + 19766894 + + + + + + + + 2009 + 11 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + posttranslationally regulated by reversible S-nitrosylation in neuroblastioma cell line + + + + 19056486 + + + + + + + + 2009 + 11 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The majority of chordomas express EGFR immunohistochemically but only about one-forth show alterations of the EGFR gene. + + + + 19886182 + + + + + + + + 2009 + 11 + 30 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Elevated CD133, but not VEGF or EGFR, may be a predictive marker of distant recurrence and poor survival after preoperative chemoradiotherapy in rectal cancer + + + + 19724847 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations were more frequently observed in females, in non-smokers, and in the presence of bronchioloalveolar features in 411 lung adenocarcinomas . + + + + 19724844 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a mechanism linking EGFR signaling with Fyn and Src activation to promote glioblastoma progression and invasion in vivo + + + + 19690143 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is expressed in bilary tract cancer + + + + 19777609 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations are associated with good response to gefitinib therapy. + + + + 19530244 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + associated with non-small lung cancer + + + + 19185949 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + lapatinib inhibits the nuclear translocation of EGFR and HER2 and downregulates TS, thus sensitizing cancer cells to fluoropyrimidine + + + + 19529774 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + polymorphisms in EGFR are potential predictors for clinical outcome in advanced NSCLC patients treated with Gefitinib + + + + 19201048 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, c-Met, and VEGFR1 involved in carcinogenesis are well-represented and coexpressed in anal cancers, especially in HIV-positive population + + + + 19716155 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR protein overexpression and increased EGFR gene copy number is associated with sarcomatoid carcinomas of the lung. + + + + 19681124 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data demonstrate that proper internalization and endocytic trafficking are critical for EGFR-mediated signaling in A549 cells and suggest that up-regulation of Rin1 in A549 cell lines may contribute to their proliferative nature. + + + + 19570984 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. + + + + 19469909 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CCHCR1 is up-regulated in skin cancer and associated with EGFR expression + + + + 19551138 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF is expressed and produced by annulus cells in vivo and in 3D culture + + + + 19535298 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + histone deacetylase inhibition may not only reactivate silenced ER, but also simultaneously deplete EGFR expression + + + + 18683042 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + novel cross talk occurs between tumor necrosis factor receptor and TGF-alpha/epidermal growth factor receptor in stimulating human bone marrow mesenchymal stem cell hepatocyte growth factor production + + + + 19692652 + + + + + + + + 2009 + 11 + 23 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Tetraspanins are co-immunoprecipitated with EGFR in both A431 and KB cells, indicating that TSPs are closely associated with EGFR. + + + + 19559406 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + There was a statistically significant correlation between EGFR expression and histological grade. Stage classification was the only parameter in multivariate analysis that was an independent predictor of low overall and disease-free survival. + + + + 19317849 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + intestinal epithelial cancer cells commonly display an EGFR-mediated sustained activation of Src under anoikis conditions + + + + 19479902 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The expression of EGFR may be associated with postoperative recurrence of Dukes'A and B colorectal carcinoma. + + + + 17562274 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Using lung adenocarcinoma samples and cell lines derived from lung adenocarcinomas, we demonstrated that the gene copy number for MET in lung adenocarcinoma tissue samples was increased over EGFR, HGF, and PXN and that it correlated with better prognosis + + + + 19817696 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Studies show that the intrinsic molecular signature of five markers, ER, PR, HER-2, CK 5/6, and EGFR, demonstrated specificity of 100% and sensitivity of 75%, compared with classification by gene expression profiling. + + + + 19720911 + + + + + + + + 2009 + 11 + 2 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mathematical modeling was used to investigate the relationship between EGF internalization kinetics, EGFR expression, and internalization machinery. + + + + 19297331 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We confirm EMP-1 is abnormally expressed in intractable epilepsy and suggest the interaction of EGFR and EMP-1 plays a role in the mechanism of drug resistance in epilepsy + + + + 19288191 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis + + + + 19702827 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + 3 of 11 cases (27.3%) were positive for EGFR + + + + 19283847 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gefitinib monotherapy confers substantial clinical benefit in terms of progression-free survival and overall survival in non-small cell lung cancer patients with EGFR mutations. + + + + 19531624 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + phosphorylation and activation of GSTP1 by EGFR as a novel, heretofore unrecognized component of the EGFR signaling network + + + + 19254954 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells. + + + + 19714638 + + + + + + + + 2009 + 10 + 26 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The combined measurement of PTEN and MMP9 transcripts might represent a novel reliable tool for the differential diagnosis of high-grade gliomas. + + + + 19657395 + + + + + + + + 2009 + 10 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Report negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. + + + + 19713535 + + + + + + + + 2009 + 10 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by GPR30. + + + + 19342448 + + + + + + + + 2009 + 10 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + UV irradiation stimulates rapid EGFR nuclear translocation, which is dependent on phosphorylation of specific EGFR tyrosine residues. + + + + 19415674 + + + + + + + + 2009 + 10 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PML was found to be important for E1A-induced suppression of EGFR and subsequent killing of head and neck squamous cell carcinoma cells suggesting a novel pathway involving PML and p73 in the regulation of EGFR expression. + + + + 19597475 + + + + + + + + 2009 + 10 + 19 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results compare the effect of six different ligands on endocytic trafficking of epidermal growth factor receptors and show that they have very diverse effects on endocytic sorting. + + + + 19531065 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ZIP is a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis + + + + 19644445 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of the EGFR gene in many Wilms tumor cases warrants further study to determine the therapeutic benefit of EGFR inhibitors in combination with other therapies in Wilms tumor patients. + + + + 19781441 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Studied assoc'n of EGFR & ESR1 SNPs with breast cancer risk/prog. in Tunisian patients. No evidence found for assoc'n between EGFR R521K polymorphism and breast cancer risk,but homozygous GG(Arg)genotype more prevalent in patients w/lymph node metastasis. + + + + 19636371 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Activating mutations within the EGFR TK domain can be used to predict the risk of recurrence in curatively resected pulmonary adenocarcinoma. + + + + 19517135 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the smoking dose predicted EGFR mutations with a moderate diagnostic accuracy in patients with non-small-cell lung cancer. + + + + 19650855 + + + + + + + + 2009 + 10 + 12 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Elortinib seems to be site specific for intracranial metases harboring EGFR exon 19 deletions. + + + + 19550250 + + + + + + + + 2009 + 10 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A considerable proportion of NSCLC showed discrepancy in EGFR mutations between primary tumors and metastatic lymph nodes, suggesting tumor heterogeneity at the molecular level during the process of metastasis. + + + + 19487967 + + + + + + + + 2009 + 10 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Findings suggest that in microsatellite instability-positive tumors current therapies targeting EGFR overexpression may have either no effect or an opposite to the expected effect. + + + + 19584170 + + + + + + + + 2009 + 10 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results suggest that the mutations of EGFR, KRAS, BRAF between primary tumors and corresponding lymph node metastases should be considered whenever mutations are used for the selection of patients for EGFR-directed tyrosine kinase inhibitor therapy. + + + + 19584155 + + + + + + + + 2009 + 10 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Beta-arrestin is required for the maintenance of a beta1-Adrenergic receptor -epidermal growth factor receptor interaction that can direct cytosolic targeting of extracellular regulated kinase in response to catecholamine stimulation. + + + + 19509284 + + + + + + + + 2009 + 10 + 5 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that compared with the EGFR mutant and WT/WT cohorts, patients with EML4-ALK mutant tumors were significantly younger and were more likely to be men. + + + + 19667264 + + + + + + + + 2009 + 9 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data indicate overexpression of EGFR in A431 cells and low expression in SW962 cells. + + + + 19723115 + + + + + + + + 2009 + 9 + 28 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression by tumor cells of the breast cancer defines a specific subset of tumors with poor prognosis and potential resistance to the adjuvant therapy. + + + + 19434314 + + + + + + + + 2009 + 9 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show that DUSP4 is involved in negative feedback control of EGFR signaling, and provide functional validation for its role as a growth suppressor in EGFR-mutant lung adenocarcinoma. + + + + 19525976 + + + + + + + + 2009 + 9 + 21 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR immunoreactivity significantly correlates with worse prognosis in patients with triple-negative Invasive ductal carcinomas + + + + 18839307 + + + + + + + + 2009 + 9 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + irradiation-induced activation of EGFR upregulates Pim-1 + + + + 19568408 + + + + + + + + 2009 + 9 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Enhanced multipotent stromal cells osteogenic differentiation corresponds to a sustained combination of receptor expression and ligand presentation, both of which are maintained by tethered epidermal growth factor. + + + + 19544388 + + + + + + + + 2009 + 9 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations possess statistical significance for a better therapy response and longer survival in all patients with adenocarcinomas (smokers as well as non-smokers). + + + + 19596959 + + + + + + + + 2009 + 9 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In MDA-MB-231 breast cancer cells, GRP-R and EGF-R synergize to regulate cell migration and IL-8 expression, but not cell proliferation. + + + + 19631337 + + + + + + + + 2009 + 9 + 14 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that the AP-2 complex is involved in the internalization of activated epidermal growth factor receptor from the cell surface. + + + + 19351721 + + + + + + + + 2009 + 9 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Most cases os synovial sarcoma showed overexpression of EGFR protein, but it was not accompanied by gene amplification. + + + + 19670699 + + + + + + + + 2009 + 9 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR copy number changes could supplement the clinical significance of EGFR as a marker related to its pathogenesis and targeted therapy. + + + + 19670535 + + + + + + + + 2009 + 9 + 7 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Lack of association between common polymorphisms of epidermal growth factor receptors and nonsyndromic cleft lip with or without cleft palate. + + + + 19307027 + + + + + + + + 2009 + 8 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that aberrantly increased expression of miR-21, which is enhanced further by the activated EGFR signaling pathway, plays a significant role in lung carcinogenesis in never-smokers, as well as in smokers. + + + + 19597153 + + + + + + + + 2009 + 8 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression is involved in the pathogenesis of phyllodes tumors + + + + 18443904 + + + + + + + + 2009 + 8 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the results indicated that EGFR overexpression and histologic subtyping by predominant tumor cell type in mucin pools may be helpful for predicting clinical outcome in patients with MGC. + + + + 19479974 + + + + + + + + 2009 + 8 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + There was no statistically significant association between epidermal growth factor receptor mutations and the clinical characteristics. + + + + 19543508 + + + + + + + + 2009 + 8 + 31 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, NFkappaB, and STAT3 are required for human iNOS gene induction in proximal tubule cells in response to pressure or EGF, indicating a similar mechanism of activation. + + + + 19403642 + + + + + + + + 2009 + 8 + 24 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Immunohistochemical expression of EGFR is variable between laboratories, even using standardised protocols + + + + 19404848 + + + + + + + + 2009 + 8 + 24 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene amplification, protein over-expression and no mutation in tyrosine kinase domain is associated with recurrent glioblastoma. + + + + 18752056 + + + + + + + + 2009 + 8 + 24 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our findings suggest modified bladder cancer risk and survival associated with genetic variation in the EGFR pathway. + + + + 19372140 + + + + + + + + 2009 + 8 + 17 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The thyroid tumor was focally positive for EGFR (immunostaining) and two point mutations were identified, one on exon 18 and one on exon 20 in the tyrosine kinase (TK) domain. + + + + 19276143 + + + + + + + + 2009 + 8 + 17 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Fibrinogen binding to ICAM-1 promotes mucin production by decreasing TGF-alpha-induced EGFR and ERK1/2 activation. + + + + 19429776 + + + + + + + + 2009 + 8 + 17 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Combination of MET and EGFR inhibitors triggered stronger inhibition on cell proliferation and invasion of MPM cells than that of each in vitro. + + + + 19380521 + + + + + + + + 2009 + 8 + 17 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The activation of SHP-2 phosphorylation at Tyr542 in glioblastoma cell lines results in increased PTPase activity and distinct mechanisms of cell cycle progression and SHP-2. Its PTPase activity plays a critical role in EGFRvIII-mediated transformation. + + + + 19427850 + + + + + + + + 2009 + 8 + 17 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results showed that 45.8% of typical carcinoid and 28.6% of atypical carcinoid tumors express EGFR, 100% of the tumors lack expression of ErbB2, and 100% have moderate to intense staining for ErbB3 and ErbB4. + + + + 19447869 + + + + + + + + 2009 + 8 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab in Non-Small-Cell Lung neoplasms + + + + 19276677 + + + + + + + + 2009 + 8 + 10 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The authors show that virus infection results in the profound upregulation of Wilms' Tumour 1 (WT1) protein, a transcription factor associated with the negative regulation of a number of growth factors and growth factor receptors, including EGFR. + + + + 19321755 + + + + + + + + 2009 + 8 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings suggest that ouabain downregulates mCD14 expression on monocytes through EGFR transactivation and p38 MAPK activation. + + + + 19365146 + + + + + + + + 2009 + 8 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HER1 and 2 do not seem to have a role in endometriosis physiopathology. + + + + 19294416 + + + + + + + + 2009 + 8 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation is associated with metastatic in non-small cell lung cancer. + + + + 19404216 + + + + + + + + 2009 + 8 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results describe the expression pattern of p53, BCL-2 and epidermal growth factor receptor proteins in the hydatidiform moles. + + + + 19348791 + + + + + + + + 2009 + 8 + 3 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of distinct EGFR mutations in non-small cell lung cancer + + + + 19147750 + + + + + + + + 2009 + 7 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results revealed significantly increased levels of epidermal growth factor in both serum and bronco-alveolar lavage. + + + + 19093231 + + + + + + + + 2009 + 7 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Haploinsufficiency of the tumor suppressor ANXA7 due to monosomy of chromosome 10 provides a clinically relevant mechanism to augment EGFR signaling in glioblastomas beyond that resulting from amplification of the EGFR gene. + + + + 19602687 + + + + + + + + 2009 + 7 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ErbB-1/-2 receptors are inhibited by lapatinib in bladder neoplasms + + + + 19287975 + + + + + + + + 2009 + 7 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that Dsg1 is required for maintaining epidermal tissue integrity in superficial layers, supports keratinocyte differentiation and suprabasal morphogenesis, and is required for suppression of epidermal growth factor receptor signaling. + + + + 19546243 + + + + + + + + 2009 + 7 + 27 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + R497K polymorphism of Epidermal growth factor receptor gene may be associated with DCM in a Chinese population. + + + + 19265688 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + [CA]n genotype appears to be a useful predictive marker of the development of skin rashes with gefitinib treatment + + + + 18995924 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mutations in exons 19 or 21 are considered to be a good predictor of the efficacy of gefitinib therapy for non-small cell lung cancer + + + + 18992959 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + high HER2 and EGF protein levels were significantly correlated with TOB1 expression in breast cancer, whereas EGFR and EGF levels correlated with TOB1 phosphorylation + + + + 19491269 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings show that EGFR and ErbB2 can negatively regulate androgen receptor (AR) mRNA and may provide an approach to suppress AR expression in CRPC + + + + 19491261 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that one mechanism of the apoptotic activity of magnolol involves its effect on epidermal growth factor receptor-mediated EGFR/PI3K/Akt signaling transduction pathways. + + + + 19229860 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Elevated EGFR is associated with less favorable disease outcome in ovarian cancer. + + + + 19374540 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Increased EGFR gene copy number was related to a high SUV(max) on FDG-PET + + + + 18819724 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + examined the effect of EGFR mutations and BRCA1 mRNA levels on outcome in advanced non-small-cell lung cancer + + + + 19415121 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The mechanism of aldosterone related mesangial cell proliferation was studied, revealing the role of EGF receptor transactivation through a redox-sensitive process. + + + + 19339632 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the role of transcriptional regulation of conserved dinucleotide repeats in intron 1 of the EGFR gene might be conserved in other ErbB genes. + + + + 18946768 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + genetic polymorphism is associated with a significantly increased risk of female lung adenocarcinoma + + + + 19026460 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutation in EGFR is associated with adrenocortical carcinomas. + + + + 19190079 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Study shows that the intracellular juxtamembrane segment of the EGF receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. + + + + 19563760 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR was found to be overexpressed in all oral tongue squamous cell carcinomas making this cancer type interesting for exploring new therapeutic agents targeting the EGFR receptor. + + + + 19332367 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + high gene copy number might be associated with shorter survival in patients with non-small-cell lung cancer in Japan + + + + 19058870 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show that inhibition of angiogenesis by gefitinib seems independent on the EGFR genetic status of the tumors. + + + + 19435839 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In patients with non-small cell lung cancer, there is a higher frequency of epithelial markers in patients with EGFR mutation. + + + + 19353773 + + + + + + + + 2009 + 7 + 20 + 11 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation up-regulates EGR1 expression through the ERK pathway. + + + + 19414352 + + + + + + + + 2009 + 7 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Absence of mutations in the epidermal growth factor receptor (EGFR) kinase domain in patients with mesothelioma. + + + + 19333077 + + + + + + + + 2009 + 7 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding. + + + + 19336395 + + + + + + + + 2009 + 7 + 6 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The suppression of VEGF expression by Ganoderma tsugae methanol extract can be restored by treatment with EGF suggesting that GTME inhibits VEGF expression via the suppression of EGFR expression. + + + + 19332363 + + + + + + + + 2009 + 6 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations is associated with non-small-cell lung cancer. + + + + 19366827 + + + + + + + + 2009 + 6 + 29 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Study concludes that endosomal localization of Lst2, along with an ability to divert incoming EGFR molecules to degradation in lysosomes, is regulated by ubiquitinylation/deubiquitinylation cycles. + + + + 19460345 + + + + + + + + 2009 + 6 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of th EGFR-ERK1/2 signalling pathway. + + + + 18986301 + + + + + + + + 2009 + 6 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells. + + + + 19213840 + + + + + + + + 2009 + 6 + 22 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene amplification seems to be restricted to high-grade tumors, WHO grade IV astrocytomas, and grade III oligodendroglial tumors. + + + + 19391220 + + + + + + + + 2009 + 6 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings are consistent with the hypothesis that EGFR signaling plays an important role in A549 cell physiology and acts synergistically with claudin-2 to accelerate tumor colonizati + + + + 18942115 + + + + + + + + 2009 + 6 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells is characterized by multiplex kinase activity profiling + + + + 19294521 + + + + + + + + 2009 + 6 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression and KRAS mutation status is predictive for clinical response to matuzumab +/- paclitaxel in patients with advanced NSCLC. + + + + 19276157 + + + + + + + + 2009 + 6 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer. + + + + 19414683 + + + + + + + + 2009 + 6 + 15 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Enediyne lidamycin enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib, in epidermoid carcinoma A431 cells and lung carcinoma H460 cells. + + + + 19342999 + + + + + + + + 2009 + 6 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In contrast to trastuzumab sensitive breast cancer cells, combinatorial targeting of ERBB receptors or of key signaling intermediates does not have potential for treatment of de novo trastuzumab resistant cells. + + + + 19118495 + + + + + + + + 2009 + 6 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. + + + + 19153117 + + + + + + + + 2009 + 6 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. + + + + 19150933 + + + + + + + + 2009 + 6 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Inhibition of both AR isoforms did not affect EGFR and ERBB2 transcript levels but decreased EGFR and increased ERBB2 protein levels. Proliferation of 22Rv1 cells in SDM was inhibited in the absence of AR and ARDeltaCTD. + + + + 19318561 + + + + + + + + 2009 + 6 + 8 + 11 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Breast cancer cell line subpopulations differed in the amplification of the egfr-locus 7p11-14 showing egfr gene amplification rates of up to 60-fold in high-level expressing populations and less than 2-fold in low-level expressing populations. + + + + 18751981 + + + + + + + + 2009 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Depletion of SCAMP3 in HeLa cells by inhibitory RNA accelerated degradation of EGFR and EGF while inhibiting recycling + + + + 19158374 + + + + + + + + 2009 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR staining was seen in the majority of uterine serous carcinoma patients + + + + 19272638 + + + + + + + + 2009 + 5 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Meta-analysis of gene-disease association. (HuGE Navigator) + + + + 20840818 + + + + + 19430813 + + + + + + + + HuGENet + + + 1956.19430813 + + + + + HuGENet + + + + + + + 2009 + 5 + 17 + 21 + 32 + 0 + + + + + + + + + 2009 + 5 + 17 + 21 + 32 + 0 + + + + + + + 18 + EGFR-targeted gelatin-based engineered nanocarrier systems show tremendous promise an effective gene delivery vector with the potential to treat pancreatic cancer. + + + + 19034673 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. + + + + 19217205 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. + + + + 19347870 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the interplay between Nedd4-2-related E3 ligases that regulate ACK1 levels and Cbl that modifies EGF receptor impinges on cell receptor dynamics. + + + + 19144635 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations not only increase receptor activity, but also alter responses of downstream signaling cascades in human non-small cell lung cancer cell lines. + + + + 19002495 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the AC/cAMP/Epac signaling pathway in ovary may mediate the up-regulation of EGFR by gonadotropins via ERK1/2 and Akt activation + + + + 19022848 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The combination of EGFR expression and growth pattern is a strong prognostic indicator for improved survival in non-small-cell lung cancer treated with gefitinib. + + + + 18787840 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + cDNA microarray analysis does not indicate any specific target or treatment effects of head and neck squamous cell carcinoma with mutant P53 and over-expressed EGFR. + + + + 18758819 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + exploiting the smaller heavy chain antibodies of camels against EGFRvIII seems promising in the diagnosis procedures of thyroid neoplasms. + + + + 19330625 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + An amino acid substitution in EGFR polymorphism may be associated with favorable prognosis of advanced lung cancers. + + + + 18726117 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens. + + + + 19276385 + + + + + + + + 2009 + 5 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Erlotinib and gefitinib inhibited EGFR and ERK1/2 phosphorylation/activation in all GBMs, irrespective of the antiproliferative response observed. + + + + 19147502 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM9/10-mediated mechanism. + + + + 19394555 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor gene mutations may have roles in malignant pleural effusion of lung adenocarcinoma + + + + 18508816 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + missense mutations were observed in 18 of 161 glioblastoma cases; 4 novel mutations were detected; mutations of the EGFR extracellular domain were not associated with overall survival or age at onset, but were significantly associated with gender + + + + 19284481 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mutant EGFR-Src interaction and cooperativity play critical roles in constitutive engagement of the downstream signaling pathways that allow NSCLC-associated EGFR mutants to mediate oncogenesis. + + + + 19305428 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor mediates allergic airway remodelling + + + + 18653647 + + + + + + + + 2009 + 5 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The novel coupling of antiviral defense machinery (i.e., TLR3) and major epithelial proliferation/repair pathway (i.e., EGFR) might play an important role in viral-induced airway remodeling and airway disease exacerbation. + + + + 18978302 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations may be a valuable prognostic factor for disease free survival of surgically treated lung adenocarcinoma patients independently from adjuvant chemotherapy + + + + 18985444 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Human eccrine sweat glands express CK7, CK8, CK14, CK18, CK19, CEA, EMA, Ki67, p63, EGF and EGFR. In skin, CEA can be used as a specific immunological marker of sweat glands. + + + + 19032382 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. + + + + 19129184 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + K-ras, EGFR, and BRAF mutations are disproportionately seen in adenocarcinomas of lung with a dominant micropapillary growth pattern compared with conventional adenocarcinoma in our institutional experience. + + + + 19369630 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ephrinA5 acted as a tumor suppressor in glioma, and its negative regulation of EGFR contributed to the suppressive effects. + + + + 19270726 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell proliferation and expression of EGFR of tumor cells can be inhibited by transfection of CKLFSF8. + + + + 16806010 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + GM3-mediated inhibition of EGFR phosphorylation is caused by interaction of GM3 with GlcNAc-terminated N-glycan on EGFR. + + + + 19124464 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A subset of nonmucinous adenocarcinomas, not necessarily of the bronchioloalveolar type, is related to EGFR mutations + + + + 19289583 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene gain does not impact survival after resection in non-small-cell lung cancer. + + + + 19255323 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cytologic specimens were more likely to have an epidermal growth factor receptor mutation than surgical specimens + + + + 19347832 + + + + + + + + 2009 + 5 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) + + + + 19372140 + + + + + + + + HuGENet + + + 1956.19372140 + + + + + HuGENet + + + + + + + 2009 + 4 + 29 + 21 + 32 + 0 + + + + + + + + + 2009 + 4 + 29 + 21 + 32 + 0 + + + + + + + 18 + To the best of our knowledge, this is the first report describing crosstalk/interactions between SSTRs and ErbBs. + + + + 19070659 + + + + + + + + 2009 + 4 + 25 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mutations in EGFR and copy number gains in EGFR and HER2 were independent factors related to gefitinib sensitivity, in descending order of importance + + + + 19238210 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + No evidence for an apparent association of common genetic polymorphisms in EGFR with breast cancer risk. + + + + 19190167 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations were never found in tumors with KRAS mutations, suggesting a mutually exclusive relationship. + + + + 19270482 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a high frequency of the EGFR-activating mutations in papillary thyroid carcinoma (PTC) suggests that the EGFR mutation may be an important event in the development of PTC. + + + + 19253367 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Study shows that genomic instability due to Myc amplification may cause specific amplification of EGFR and/or ERBB2 in gallbladder adenocarcinoma. + + + + 19331129 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR activation by H pylori infection has an antiapoptotic effect in gastric epithelial cells that appears to involve Akt signaling and Bcl family members. + + + + 19250983 + + + + + + + + 2009 + 4 + 18 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin is able to disrupt epidermal homeostasis and identify + + + + 19255421 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + smoking status alone appears inappropriate in selecting patients for EGFR-TKI treatment. + + + + 18789554 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ARAP1 controls the late steps of the endocytic trafficking of the EGF-R + + + + 18764928 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Low EGFR expression might be a predictive marker for relapse in curative resected stage III-IV (M0) gastric cancer patients who received adjuvant FP chemotherapy. + + + + 19259093 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047. + + + + 19138820 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation + + + + 18939958 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations indicates that they are related to the mechanism of the pathogenesis of lung cancer. + + + + 18760859 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings provide critical insights into the role of mutant EGFR signaling function in glioblastoma multiforme tumor biology + + + + 19196966 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + For urine cytology, immunostaining method with epidermal growth factor receptor and p53 was useful for the differential diagnosis. + + + + 19248552 + + + + + + + + 2009 + 4 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + present data clearly show that EGFR status is independent of K-Ras mutations in colorectal tumors + + + + 18632722 + + + + + + + + 2009 + 4 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR to attenuate the EGF-induced cell migration. + + + + 19267780 + + + + + + + + 2009 + 4 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + overexpression of EGFR is associated with thymic carcinoma. + + + + 19267104 + + + + + + + + 2009 + 4 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data suggest that mutation frequency of EGFR in NSCLCs from Chinese patients is higher than that of western ethnicities, such mutations are well correlated with tumor response to gefitinib, and gefitinib is more fit for Chinese NSCLC patients. + + + + 17285540 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations in the tyrosine kinase domain is a rare event in salivary gland carcinomas. + + + + 19174819 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with optimal resectability in malignant peritoneal mesothelioma. + + + + 18998063 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our findings have confirmed a key role of EGFR in determining the proliferative and malignant potential of laryngeal carcinoma + + + + 19148533 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression may represent an adverse prognostic marker in patients with triple-negative breast cancer + + + + 19148516 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + BRCA1-mutant mammary epithelials prdispos to the developmnt os estrogen receptor negative, EGFR positive breast cancers. + + + + 19190334 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients with advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations show response to gefitinib. + + + + 19224850 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Microvesicles produced by human cancer cells harboring activated EGFR (A431, A549, DLD-1) can be taken up by cultured endothelial cells, in which they elicit EGFR-dependent responses, including activation of MAPK and Akt pathways. + + + + 19234131 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR may represent a molecular marker predictive for poor response to preoperative chemoradiotherapy in locally advanced gastric carcinoma. + + + + 19016018 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show that epidermal growth factor receptor inhibition stabilizes desmoglein 2 at intercellular junctions by interfering with its accumulation in an internalized cytoplasmic pool. + + + + 18987342 + + + + + + + + 2009 + 3 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signals to mTOR through PKC and independently of Akt in glioma + + + + 19176518 + + + + + + + + 2009 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + MET amplification is present in untreated NSCLC and EGFR mutation or MET amplification activates MET protein in NSCLC + + + + 19117057 + + + + + + + + 2009 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + There were multi-nucleotide in-frame deletion mutations in exon 19 of EGFR gene. Mutations of the exon 19 of EGFR gene were higher in female, non-smoking and adenocarcinoma lung cancer patients. + + + + 18543225 + + + + + + + + 2009 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results suggest that clusterin requires EGFR activation to deliver its mitogenic signal through the Ras/Raf-1/MEK/ERK signaling cascade in astrocytes + + + + 19218870 + + + + + + + + 2009 + 3 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Somatic mutation in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene is associated with the sensitivity of non-smal cell lung cancer (NSCLC) to TK inhibitor Gefitinib. + + + + 17548322 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Substantial discordance in EGFR and K-RAS mutational status between the primary tumours and corresponding metastases in patients with non-small-cell lung cancer. + + + + 19238633 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + T790M-EGFR mutation is associated with relapses in lung cancer. + + + + 19238632 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HER2 affects glial-cell migration by modulating EGFR-HER2 signal transduction, and that this effect is mediated by N-cadherin. + + + + 19033391 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells. + + + + 19138957 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In EGFR-mutant adenocarcinoma metastases, the higher levels of EGFR overexpression and more homogeneously distributed high gene copy numbers suggest tumor progression. + + + + 19138956 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The switch in EGFR ligand availability as advanced prostate cancer progresses affects cell survival and contributes to bone remodeling. + + + + 19143022 + + + + + + + + 2009 + 3 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFRvIII and PTEN protein by glioblastoma cells is strongly associated with clinical response to EGFR kinase inhibitor therapy + + + + 16912159 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The EGFRvIII is expressed in HNSCC where it contributes to enhanced growth and resistance to targeting wild-type EGFR. + + + + 16951222 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Bacterial products (e.g., LPS) triggers a positive feedback loop involving COX-2/PGE(2) in biliary carcinoma cells and this second phase of EGFR phosphorylation is implicated in cell invasion by LPS + + + + 19201881 + + + + + + + + 2009 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR protein is frequently expressed in a subset of patients with chemorefractory metastatic embryonal carcinoma + + + + 18660793 + + + + + + + + 2009 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Phosphorylation of EGFR at Tyr992 may play some specific functional role in esophageal carcinomas besides promotion of cell proliferation , probably dysregulation of the downstream signal transduction pathways. + + + + 19133013 + + + + + + + + 2009 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Germ-line and somatic mutations of the EGFR T790M is associated with lung cancer. + + + + 19096324 + + + + + + + + 2009 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor-mutation has a positive non-small cell lung cancer response to Erlotinib combined with cyclosporine in a liver-transplant recipient. + + + + 19096323 + + + + + + + + 2009 + 3 + 7 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF transregulates opioid receptors through EGFR-mediated tyrosyl phosphorylation and activation of GRK2; GRK2 may be a mediator of cross-talk from RTK to GPCR signaling pathway + + + + 18463167 + + + + + + + + 2009 + 2 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene expression in pancreatic adenocarcinoma cells significantly surpassed that in normal pancreatic cells. + + + + 19110611 + + + + + + + + 2009 + 2 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. + + + + 18958173 + + + + + + + + 2009 + 2 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Somatic mutations of EGFR or KIT of the thymomas and thymic carcinomas are presented in a small number of patients. + + + + 18448188 + + + + + + + + 2009 + 2 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and BRCA1 might be candidate therapeutic targets in triple-negative breast cancer + + + + 18950515 + + + + + + + + 2009 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + rhomboid family-1 is critically involved in a G protein-coupled receptors ligand-stimulated process leading to the activation of latent epidermal growth factor receptor ligands + + + + 18832597 + + + + + + + + 2009 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + increase in both gene expression and gene copy number in Chinese patients with gastric carcinoma; likely due to chromosome 7 polysomy + + + + 19061514 + + + + + + + + 2009 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Novel EGFR mutation D1012H and polymorphism at exon 25 is associated with lung cancer. + + + + 18478265 + + + + + + + + 2009 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and erbB2 are potential targets in treatment of Malignant peripheral nerve sheath tumors + + + + 18650488 + + + + + + + + 2009 + 2 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression represent important alterations that are related to the molecular pathways underpinning colorectal carcinogenesis + + + + 19102009 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene mutations are frequently seen in lung adenocarcinomas with bronchioloalveolar differentiation and can be linked to chromosomal imbalances and increased VEGF expression + + + + 18450321 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Polymorphisms in COX-2 and EGFR may be useful independent molecular markers to predict clinical outcome in patients with mCRC treated with single-agent cetuximab + + + + 19047118 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR took part in development and progression of colorectal carcinomas and that Id-1 was associated with regulations of EGFR + + + + 19014499 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the mutational spectrum of somatic mutations of EGFR in non-small cell lung cancer (Analytical database) + + + + 18670300 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In stage III non-small cell lung cancer, there was a significant association between TTF-1 and EGFR + + + + 18355939 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Growth and molecular interactions of the anti-EGFR antibody cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: new prospects in the treatment of triple-negative/basal-like breast cancer. + + + + 19020749 + + + + + + + + 2009 + 2 + 14 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our data determine that higher-order EGFR oligomers are the dominant species associated with the ligand activated EGFR tyrosine kinase. + + + + 18937111 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + lung epithelial cells secrete AMCase via an EGFR-dependent pathway that is activated by ADAM17 and mediates its effects via Ras. + + + + 18824549 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression occurred independently of histological type and clinical parameters in salivary gland carcinomas + + + + 18983466 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results highlight the prognostic value of CDK4 amplification and of simultaneous EGFR-p53 alterations in the clinical outcome of patients with primary GBM. + + + + 19141386 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small cell lung cancer. + + + + 18978556 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + H. pylori blocks EGFR endocytosis and receptor degradation upon prolonged infection of gastric epithelial cells. + + + + 19016792 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR is a significant predictor of clinical response to fluoropyrimidines in colorectal cancer. + + + + 19033715 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in epidermal growth factor receptor is associated with non-small cell lung cancer. + + + + 18827621 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor intron-1 polymorphism is associated with gefitinib response in advanced non-small cell lung cancer. + + + + 18827605 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations are associated with non-small cell lung cancer. + + + + 18827604 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + As the upstream of Akt activation, H. pylori infection activated epidermal growth factor receptor (EGFR) at Tyr 992, phosphatidylinositol 3-OH kinase (PI3K) p85 subunit and PI3K-dependent kinase 1 at Ser 241. + + + + 18782353 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR-related markers, pERK, pSTAT3, E-cadherin, pCMET and mutations in KRAS were associated with survival of NSCLB patients. + + + + 19050706 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. + + + + 19088723 + + + + + + + + 2009 + 1 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The median survival time of patients with the EGFR somatic mutation was significantly longer in patients with advanced non-squamous, non-small cell lung cancer + + + + 18811692 + + + + + + + + 2009 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Pre-formed EGFR dimers are critical to the initial EGF binding and the extent of the pre-formed dimers is not affected by receptor density. + + + + 19014905 + + + + + + + + 2009 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways + + + + 18790560 + + + + + + + + 2009 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells + + + + 18806258 + + + + + + + + 2009 + 1 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Taken together, these data provide direct evidence of the dependence of IFNgamma-induced EGFR transactivation upon EFDR receptor expression level in epithelial cells. + + + + 19062522 + + + + + + + + 2009 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that EGFR was expressed more frequently in metastatic and primary tumour tissues as revealed by immunohistochemistry. + + + + 18936523 + + + + + + + + 2009 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Doublets in the EGFR and TP53 genes in human lung cancer are elevated about eight- and three-fold, respectively, relative to spontaneous doublets in mouse (6% and 2.3% versus 0.7%). + + + + 19005564 + + + + + + + + 2009 + 1 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observational study and meta-analysis of gene-disease association. (HuGE Navigator) + + + + 19064572 + + + + + + + + HuGENet + + + 1956.19064572 + + + + + HuGENet + + + + + + + 2009 + 1 + 11 + 21 + 30 + 0 + + + + + + + + + 2009 + 1 + 11 + 21 + 30 + 0 + + + + + + + 18 + Activated EGFR is reported as a novel target in pancreatic cancer therapy. + + + + 18821783 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and TLR4 in 16HBE14o- cells stimulated with meprin alpha. NFkappaB was also activated via MyD88 in these cells by meprin alpha + + + + 18772136 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + acquired resistance to ATP-mimetic EGFR kinase inhibitors may often be associated with amino acid substitutions that alter drug contact residues in the EGFR ATP-binding pocket + + + + 19010870 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + no association of the two promoter EGFR polymorphisms (or combinations of these polymorphisms) and risk of astrocytomas, EGFR expression or survival was found in a Brazilian population + + + + 18949739 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Progenitor sphere formation requires signaling from the EGFR tyrosine kinase. Nf1 loss of function amplifies this progenitor pool, which becomes hypersensitive to growth factors and confers tumorigenesis. + + + + 19041782 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Increased EGFR copy number was highly correlated with EGFR mutation in NSCLC patients, but less correlated with TKI responsiveness and the overall survival compared with EGFR mutations. + + + + 18304690 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations significantly predict both a survival benefit from gefitinib and a favorable prognosis in patients with advanced lung adenocarcinoma + + + + 18794545 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR autocrine system can couple multiple signaling pathways to ERK activation + + + + 18782770 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Associatiion of EGFR gene mutations with EGFR amplification in advanced non-small cell lung neoplasms is reported. + + + + 18957054 + + + + + + + + 2009 + 1 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + WWP1 may promote cell proliferation and survival partially through suppressing RNF11-mediated ErbB2 and EGFR downregulation in human cancer cells. + + + + 18724389 + + + + + + + + 2009 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + JAK2, EGFR and PI3KCA hot spot mutations are uncommon in endocrine tumors + + + + 19003996 + + + + + + + + 2009 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR as well as HER2 are prognostic factors of worse clinical outcomes, in high-risk early breast cancer + + + + 18985033 + + + + + + + + 2009 + 1 + 3 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In malignant pleural mesothelioma, epidermal growth factor receptor to play a role in a limited subset of patients + + + + 18392851 + + + + + + + + 2008 + 12 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation + + + + 18508924 + + + + + + + + 2008 + 12 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Wounding activates two distinct signaling pathways that induce EGFR activation and promote healing of wounds in epithelial cells. + + + + 18799627 + + + + + + + + 2008 + 12 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells. + + + + 18949375 + + + + + + + + 2008 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. + + + + 18844239 + + + + + + + + 2008 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Antitumor activity of cetuximab against malignant glioma cells overexpressing EGFR deletion mutant variant III is reported. + + + + 19016767 + + + + + + + + 2008 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Integrin alphavbeta3 mediates upregulation of EGFR expression and activity in ovarian neoplasms. + + + + 18577466 + + + + + + + + 2008 + 12 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Recombinant EGFR constructs containing the extracellular, transmembrane, juxtamembrane, and kinase domains are overexpressed and purified from human embryonic kidney 293 cell cultures. + + + + 18771282 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients with HER2 nonamplified and HER1 through HER3-negative tumors showed significantly increased relapse-free and overall survival rates when treated with epirubucin-CMF. + + + + 18768436 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data indicate that ERK activity, by phosphorylation of a threonine residue in the EGFR juxtamembrane cytoplasmic domain, modulates EGFR trafficking and signaling. + + + + 18762250 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mena expression in colorectal lesions. + + + + 18758639 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Regulation of hERG channels by protein tyrosine kinases modifies the channel activity and thus likely alters electrophysiological properties including action potential duration and cell excitability in human heart and neurons. + + + + 18617000 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data implicate ataxin-2 to play a role in endocytic receptor cycling. + + + + 18602463 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Immunoexpression of epidermal growth factor receptor in salivary gland-type lung carcinomas is not related to epidermal growth factor receptor gene copy number or mutational status. + + + + 18587327 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Absence of epidermal growth factor receptor mutations in cervical cancer. + + + + 17949425 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. + + + + 15838264 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + addiction (dependence on a single oncogene) to the mutationally activated EGFR in human lung cancer cells + + + + 18711136 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Distinct molecular targets of EGFR1 and EGFRvIII are identified and the importance of receptor internalization in distinguishing their specific functions, is demonstrated. + + + + 18710943 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression and genomic gains at the EGFR locus are prevalent in osteosarcoma tumors, which also commonly harbor deletions at the PTEN locus + + + + 18704985 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + 64)Cu-DOTA-cetuximab was successfully used to detect and quantify EGFR expression in cervical cancer tumors, and small-animal PET/CT of EGFR-expressing CaSki tumors suggests potential for PET/CT of EGFR-positive tumors. + + + + 18703609 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of EGFR and HER2 expression in primary cervical cancers and corresponding lymph node metastases + + + + 18700025 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High levels of EGFR is associated with head and neck squamous cell carcinoma. + + + + 18695910 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Report peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo. + + + + 18692120 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This is the first comparison of multiple, site-specific phosphoproteins with the EGFR tyrosine kinase domain mutation status in vivo. + + + + 18687633 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the length of the EGFR CA repeat polymorphism in lung carcinoma is inversely related with level of EGFR protein expression in the carcinoma + + + + 18683191 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Somatic mutations in the EGFR have emerged as important biomarkers in predicting the likelihood of tumor response to the EGFR tyrosine kinase inhibitor gefitinib in patients with advanced NSCLC. + + + + 18583573 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR protein is up-regulated in the inverted papilloma, and both synchronous and metachronous carcinoma with inverted papilloma of the nasal cavity, suggesting EGFR is involved in the transformation from inverted papilloma to squamous cell carcinoma. + + + + 18231801 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR was amplified 11% in high-grade dysplasia/esophageal adenocarcinoma cases. + + + + 18559552 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Jab1 is a target of EGFR signaling in ERalpha- cell lines and breast tumors + + + + 18534028 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We screened for mutations in exons 18 to 21 of the EGFR gene in head and neck squamous cell patients. The otherwise rare EGFR mutation p.G796S occurred in 2 patients with HNSCC + + + + 18528899 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + glioma tissue harbored numerical aberrations of the epidermal growth factor receptor gene, whereas no abnormality could be observed in necrosis or in nonglioma gliosis + + + + 18095139 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The researchers investigated the expression of epidermal growth factor receptors in synovial sarcomas and found no associated mutations in EGFR genomic sequences. + + + + 18448562 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In vascular smooth muscle cells shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation. + + + + 18667434 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR polymorphisms are associated with significant differences in the in vitro cytotoxicity of several types of DNA-interfering agents + + + + 18652519 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR activation induces COX-2 expression through PI-3K and/or p38MAPK pathways + + + + 18645679 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Sensitive detection of EGFR gene mutations in purified genomic DNA from mixed cell populations. + + + + 18440823 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The dimerization and the slow internalization of the receptor accompanied by the delayed phosphorylation of tyrosine 1068 and its degradation by the proteasome, is reported. + + + + 18727093 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Somatic mutations in the EGFR have emerged as important biomarkers in predicting the likelihood of tumor response to the EGFR tyrosine kinase inhibitor gefitinib in patients with advanced NSCLC. + + + + 18832554 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The divergent signaling functions of IGF1R and EGFR suggested the potential for synergism by a combination of therapy directed at the two receptors. + + + + 18829558 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + IMC-C225 cross-links integrins with EGFR, leading to Vav2-dependent activation of RhoA + + + + 18829495 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of epidermal growth factor receptor mutations in small cell lung cancer + + + + 18829487 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + STAT3 constitutive activation, alone and in concurrence with EGFR expression, plays an important role in high-grade/malignant gliomas and targeting STAT3/JAK2 sensitizes these tumors to anti-EGFR and alkylating agents + + + + 18829483 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In this study, we show that cell surface EGFRs promote cell growth, whereas intracellular EGF receptors promote cell death. + + + + 18817771 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Radiation-induced caveolin-1- and Receptor, Epidermal Growth Factor-phosphorylations were associated with nuclear EGFR transport and activation of DNA-Activated Protein Kinase. + + + + 18789131 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + multiple mechanisms underlie acquired gefitinib resistance, and selection on a background of EGFR genetic heterogeneity also contributes to acquisition of resistance in a proportion of nonsmall cell lung cancers + + + + 18785203 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cortactin, fascin-1 and EGFR have roles in progression of ovarian carcinomas + + + + 18776588 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + gefitinib has significant cytotoxic activity in AML by inducing apoptosis through non-EGFR dependent pathways. + + + + 18637032 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the EGFR/pEGFR phenotype has a role in progerssion of invasive breast cancer + + + + 18522728 + + + + + + + + 2008 + 12 + 15 + 11 + 36 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 20855820 + + + + + 20828860 + + + + + 20702788 + + + + + 20573926 + + + + + 20530271 + + + + + 20418097 + + + + + 20395213 + + + + + 20135347 + + + + + 20047592 + + + + + 20038723 + + + + + 20028750 + + + + + 20022809 + + + + + 19884861 + + + + + 19692680 + + + + + 19671843 + + + + + 19531624 + + + + + 19095777 + + + + + 18995924 + + + + + 18992959 + + + + + + + + HuGENet + + + 1956.18992959 + + + + + HuGENet + + + + + + + 2008 + 11 + 19 + 21 + 30 + 0 + + + + + + + + + 2008 + 11 + 19 + 21 + 30 + 0 + + + + + + + 18 + Observational study of gene-disease association and genetic testing. (HuGE Navigator) + + + + 20840812 + + + + + 18956645 + + + + + + + + HuGENet + + + 1956.18956645 + + + + + HuGENet + + + + + + + 2008 + 11 + 16 + 21 + 30 + 0 + + + + + + + + + 2008 + 11 + 16 + 21 + 30 + 0 + + + + + + + 18 + Bayesian network analysis of these and other datasets revealed that PTRF might be a potentially important component of the ERBB signaling network + + + + 18776048 + + + + + + + + 2008 + 10 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A worse tumor differentiation and a positive nodal stage were significantly associated with EGFR overexpression + + + + 18754871 + + + + + + + + 2008 + 10 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that PI-sEGFR, a proteolytic isoform of the epidermal growth factor receptor (EGFR), arises by proteolytic cleavage of EGFR via a mechanism that is regulated by both PKC- and phosphorylation-dependent pathways. + + + + 18687326 + + + + + + + + 2008 + 10 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We show that the inhibition of CK1 activates RhoB and promotes RhoB dependent actin fiber formation and EGF-R level. + + + + 18590726 + + + + + + + + 2008 + 10 + 11 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + non-small cell lung cancer patients with exon 19 deletions survived longer following gefitinib treatment than those with exon 21 point mutations + + + + 18407408 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Significant increases in EGFR copy number and EGFR immunoreactivity were found in areca-associated oral squamous cell carcinoma subjects + + + + 17468034 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells. + + + + 18253818 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Hyaluronic acid promotes CD44-EGFR interaction, which in turn activates PKC signaling, involving Akt, Rac1, Phox, and the production of ROS, FAK, and MMP-2, to enhance melanoma cell motility. + + + + 18577517 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gene-gene interaction of EGFR 497Arg>Lys and EGF +61A>G polymorphisms enhanced risk for esophageal cancer, indicating additive effects. + + + + 18773861 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In human gingival fibroblasts, enamel matrix derivative-induced extracellular regulated kinase activation and proliferation are partially due to a Src-dependent, metalloproteinase-mediated transactivation of epidermal growth factor receptor. + + + + 18719212 + + + + + + + + 2008 + 10 + 4 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observational study of gene-disease association, gene-environment interaction, pharmacogenomic / toxicogenomic, and genetic testing. (HuGE Navigator) + + + + 20504250 + + + + + 18794099 + + + + + + + + HuGENet + + + 1956.18794099 + + + + + HuGENet + + + + + + + 2008 + 10 + 1 + 21 + 30 + 0 + + + + + + + + + 2008 + 10 + 1 + 21 + 30 + 0 + + + + + + + 18 + Cardiomyocyte expression of mutant ErbB-1 leads to the blockade of ErbB-2 signaling and cardiac dysfunction. + + + + 18599591 + + + + + + + + 2008 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR FISH-positive status was associated with improved outcome after erlotinib therapy. + + + + 18559607 + + + + + + + + 2008 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene mutation was the only significant molecular predictor for time-to-progression in non small cell lung cancer. + + + + 18559606 + + + + + + + + 2008 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + there is a high expression of EGFR and/or c-kit in basal-like breast carcinoma in this series from Uganda and their expression is associated with features of poor prognosis. + + + + 18754326 + + + + + + + + 2008 + 9 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + review of EGFR, its major signaling pathways, its identification and biology in NSCLC and responsiveness to gefitinib, erlotinib and cetuximab in connection to EGFR mutations and mechanisms of resistance to tyrosine kinase inhibitors [review] + + + + 18712184 + + + + + + + + 2008 + 9 + 20 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR blockade combined with conventional chemotherapy results in anti-human soft tissue sarcomas (STS)activity in vitro and in vivo, suggesting the possibility that combining these synergistic treatments will improve anti-STS therapy. + + + + 18451246 + + + + + + + + 2008 + 9 + 20 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR and HER2, potently suppresses the kinase activity of wild-type and activated EGFR and HER2 mutants. + + + + 18408761 + + + + + + + + 2008 + 9 + 20 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) + + + + 18773861 + + + + + + + + HuGENet + + + 1956.18773861 + + + + + HuGENet + + + + + + + 2008 + 9 + 17 + 21 + 30 + 0 + + + + + + + + + 2008 + 9 + 17 + 21 + 30 + 0 + + + + + + + 18 + the hMena(+11a) isoform is associated with an epithelial phenotype and identifies EGFR-dependent cell lines that are sensitive to the EGFR inhibitor erlotinib + + + + 18676769 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CSF1, EGFR, and CA IX have roles in increasing survival in early-stage squamous cell carcinoma of the lung + + + + 18676750 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of EGFR mutations in small samples obtained from patients with non-small cell lung cancer + + + + 18676744 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF cooperates with alpha(5)beta(1) integrin signaling to induce EMT in cervical cancer cells via up-regulated Snail + + + + 18676743 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These studies demonstrate positive cross talk between ER, c-Src, EGFR, and STAT5b in ER+ breast cancer cells. + + + + 18550772 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is a key negative regulator of Notch1 gene expression in primary human keratinocytes, intact epidermis and skin squamous cell carcinomas + + + + 18604200 + + + + + + + + 2008 + 9 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + GPR30 has a role in breast tumor metastasis and transactivation of the epidermal growth factor receptor + + + + 18289622 + + + + + + + + 2008 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Clathrin-mediated endocytosis of the EGFR unexpectedly has a greater impact on receptor signaling than on receptor degradation. + + + + 18694561 + + + + + + + + 2008 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the crosstalk between genotropic and non-genotropic AR signalling interferes with signalling of EGFR in response to ligand leading to a lower invasive phenotype of AR-positive PCa cells [review] + + + + 18358509 + + + + + + + + 2008 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We found a higher protein expression of EGF-R in human heptic cirrhosis (HC) tissues, suggesting that there was autocrine circulation of EGF-R in HC tissues. + + + + 18507100 + + + + + + + + 2008 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is often expressed in thymic epithelial tumors and as such may prove to be a potential therapeutic target. + + + + 18534960 + + + + + + + + 2008 + 9 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFRvIII is not a part of the malignant phenotype in ovarian cancer + + + + 18519753 + + + + + + + + 2008 + 8 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR plays a role in the initiation of ovarian and uterine cancer and supported previous studies in breast cancer that the receptor can contribute to the neoplastic process in a significant albeit incremental way. + + + + 17960555 + + + + + + + + 2008 + 8 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the novel secreted ErbB1 isoforms may have functions distinct from the plasma membrane receptor + + + + 17910038 + + + + + + + + 2008 + 8 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results provide insight into a glutamate-induced regulatory pathway distinct from that described for cytokine-induced NF-kappaB activation and have important implications with regard to both normal glial cell physiology and pathogenesis. + + + + 18541671 + + + + + + + + 2008 + 8 + 30 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression was found in in 55 (63%) of patients with gastric cancer + + + + 18483367 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a critical role for a EGF-R-connected p60c-src-kinase-mediated pathway involving STAT3 and contributing to cell survival and proliferation within colorectal carcinomatumours. + + + + 18503159 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our data suggests that R497K polymorphism of epidermal growth factor receptor gene may be used as a genetic susceptibility marker of acute coronary syndrome + + + + 18664296 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + glioblastomas with EGFR gene amplification invariably exhibited EGFR overexpression at the level of the whole tumor, tumor cells with EGFR gene amplification did not always show EGFR overexpression at the level of individual tumor cells + + + + 18021194 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + elucidated genes not previously associated with EGFR-mutant NSCLC, two of which enhanced the clonogenicity of these cells, distinguishing these mediators from others previously shown to maintain cell survival + + + + 18030354 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR-tyrosine kinase polymorphism might be associated with clinicopathological background of lung cancers. + + + + 18541260 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study reports on the associations of EGFR mutation, amplification, and protein expression in non-small cell lung cancer + + + + 18403609 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PAR1-stimulated EGFR and ErbB2 transactivation leads to prolonged extracellular signal-regulated kinase-1 and -2 signaling and promotes breast carcinoma cell invasion. + + + + 18372913 + + + + + + + + 2008 + 8 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + more than half of the EGFR population is present in membrane rafts and smaller percentages are present in caveolae and clathrin-coated pits + + + + 18043914 + + + + + + + + 2008 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In human uterine leiomyomas, EGFR were also overexpressed. + + + + 18231572 + + + + + + + + 2008 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Present in some gastrointestinal stromal tumors, especially in small gastric tumors, and might participate in the growth regulation of human gastrointestinal stromal tumors. + + + + 18528288 + + + + + + + + 2008 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + overexpression of JKTBP1 in LNCaP cells leads to abnormal cell proliferation + + + + 18381662 + + + + + + + + 2008 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR contributes to RET kinase activation, signaling, and growth stimulation and may therefore be an attractive therapeutic target in RET-induced neoplasms + + + + 18519677 + + + + + + + + 2008 + 8 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + igh frequency of EGFR expression in osteosarcomas is associated with predominantly short alleles of EGFR-CA SSR + + + + 18464244 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib + + + + 18497962 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The p-EGFR:p-AKT ratio deserves further investigation as a predictive parameter for clinical response to erlotinib in NSCLC tumors expressing wild-type EGFR gene. + + + + 18520805 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + inhibition of HER3 may be more clinically relevant than inhibition of EGFR in HER2-amplified breast cancer and adding pertuzumab to trastuzumab may augment therapeutic benefit by blocking HER2/HER3 signaling + + + + 18632642 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of PAFR activation and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer + + + + 18632638 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + KRAS mutations are associated with cetuximab failure in EGFR FISH+ colorectal cancer. There is potential prognostic implication of IGF1R expression in colorectal cancer + + + + 18577988 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + There was a statistically significant increase in the proportion of cases with gains of EGFR in squamous cell carcinomas, compared with adenocarcinomas + + + + 18558286 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland. + + + + 18542074 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The epidermal growth factor-receptor (EGF-R) is a receptor tyrosine kinase of the ErbB family. The increased immunoreactivity of EGF was detected in serous-mucinous adenocarcinoma of the ovary. + + + + 18054376 + + + + + + + + 2008 + 8 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + acute loss of p53 in normal HKc induces EGFR expression by a mechanism that involves YY1 and Sp1 and does not require p53 binding to the EGFR promoter + + + + 18391986 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PLCgamma-1 and c-Src activation contribute to HNSCC invasion downstream of EGF receptor + + + + 18594017 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + expression and activation of c-Src as well as EGF receptor promotes head and neck squamous cell carcinoma progression + + + + 18594011 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + selected polymorphic variants in the estrogen biosynthesis and metabolism pathways are unlikely to be major genetic modifiers of the prevalence of EGFR-mutant non-small-cell lung cancer + + + + 18593984 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Somatic mutations in the exons 18 to 21 of the tyrosine kinase (TK) domain of EGFR are correlated with a high likelihood of response to EGFR TK inhibitors in advanced lung cancer. + + + + 18580100 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF contributes to differentiation and migration of myofibroblasts induced by TGF-beta1 through EGF-receptor activation and is important modulator of wound healing and scar tissue formation. + + + + 18579759 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Notch-1 upregulates EGFR expression and also demonstrate Notch-1 regulation of p53 in gliomas. + + + + 18359760 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + allelic somatic doublet mutations are present at high frequency in the epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain in lung cancers + + + + 18372921 + + + + + + + + 2008 + 8 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + in response to EGF, active MT1-MMP is directed to the leading edge of migrating cells along micropatterned fibronectin stripes, in tandem with the local accumulation of the EGF receptor + + + + 18441011 + + + + + + + + 2008 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + was no difference in the expression of EGFR, p185(erbB-2) or Bcl-2, or in nuclear accumulation of p53 in these IDC from pre- vs. post-menopausal women. + + + + 18568671 + + + + + + + + 2008 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + there is a role of the EGFR gene, now as a target of miRNA regulation in lung cancer + + + + 18508859 + + + + + + + + 2008 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + microRNA-128b directly regulates EGFR,however EGFR expression and mutation status did not correlate with survival outcome. + + + + 18304967 + + + + + + + + 2008 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Following ligand binding and receptor activation, EGFR is endocytosed and transported to lysosomes where the receptor is degraded, and this downregulation of EGFR is a complex and tightly regulated process. + + + + 18288481 + + + + + + + + 2008 + 7 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + high EGFR copy number via aneusomy is associated with metaplastic breast carcinoma + + + + 18413808 + + + + + + + + 2008 + 7 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor HKI-272 + + + + 18413800 + + + + + + + + 2008 + 7 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Hepatitis E pORF3 localizes to early and recycling endosomes and causes a delay in the postinternalization trafficking of epidermal growth factor receptor (EGFR) to late endosomes/lysosomes. + + + + 18448545 + + + + + + + + 2008 + 7 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR was associated to disease-free survival for breast cancer patients treated with 2 years of adjuvant tamoxifen. + + + + 17636398 + + + + + + + + 2008 + 7 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Macrophage migration inhibitory factor and interleukin-8 produced by gastric epithelial cells during Helicobacter pylori exposure induce expression and activation of the epidermal growth factor receptor. + + + + 18474653 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Some lung adenocarcinomas may demonstrate intratumoral heterogeneity for the occurance of EGFR mutation. + + + + 18449007 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations contribute to the acquisition of malignant potential in the AAH-AD sequence and occur independently in each lesion and in multicentric AD, BAC and AAH. + + + + 18448997 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes + + + + 18080320 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling. + + + + 18288638 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression was observed in a subset of cases with gastric carcinoma and was associated with an unfavourable prognosis. + + + + 18397279 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our data suggest that EGFR mutations are associated with papillary adenocarcinoma lung cancer + + + + 18391747 + + + + + + + + 2008 + 7 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Treatment with either SP600125, a specific chemical inhibitor of JNK, or the expression of a dominant-negative JNK form inhibited autocrine production of uPA and HB-EGF, which block EGFR phosphorylation and mitigates invasive capacity. + + + + 17654528 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Here we show that epidermal growth factor (EGF) and heregulin induce CD44 shedding in JIMT-1, an ErbB2-overexpressing cell line resistant to trastuzumab, accompanied by internalization and intramembrane proteolysis of CD44 and enhanced cellular motility + + + + 18276068 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Phosphorylated epidermal growth factor receptor is associated with tumor-associated endothelialcells in the colon + + + + 18472966 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy + + + + 18509184 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results indicate the possibility of designing BTC mutants, which have an activity of inducing differentiation only, without facilitating growth promotion. + + + + 18508082 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ADAM17 mediates the EGFR/AKT/cyclin D1 pathway and cell cycle progression to the S phase induced by UVA radiation + + + + 18483258 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + no association was apparent between EGFR expression and highly polymorphic simple sequence repeat in intron 1 (CA-SSR I) status in colorectal tumors or normal tissues + + + + 18286687 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene amplification or protein expression is not a predictor of gefitinib efficacy in Japanese patients with non-small-cell lung cancer + + + + 17932690 + + + + + + + + 2008 + 6 + 28 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with non-small-cell lung cancers + + + + 18429954 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show that EGFRvIII can be 'shared' between glioma cells by intercellular transfer of membrane-derived microvesicles ('oncosomes'). + + + + 18425114 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Exon 19 of EGFR mutation and CA-repeat polymorphism in intron 1 is associated with lung cancer + + + + 18422739 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in the epidermal growth factor receptor correlate with increased response in patients with non-small-cell lung cancer treated with EGFR tyrosine kinase inhibitors + + + + 18458038 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We characterized, for the first time, EGFR molecular alterations in Portuguese patients with malignant glioma + + + + 18507036 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Nanoprobe assay may permit quantifiable and repetitive imaging of EGFR expression in colorectal cancer. + + + + 18245533 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene mutation and amplification occurred frequently in advanced prostate cancer cases. + + + + 18302229 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings indicate that EGFR plays an important role in the maintenance of goblet cell hyperplasia. + + + + 18307528 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Altered growth factor receptor trafficking and GTP-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans + + + + 18319245 + + + + + + + + 2008 + 6 + 21 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition.[EGFRVIII] + + + + 18337449 + + + + + + + + 2008 + 6 + 7 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Functional EGFR polymorphisms is an independent prognostic markers of survival in metastatic colon cancer and is gender dependent. + + + + 18413774 + + + + + + + + 2008 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Coordinated overexpression of the EGFR pathway predicts susceptibility to EGFR inhibitors in pancreatic cancer transplanted into nude mice. + + + + 18413752 + + + + + + + + 2008 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A Met/c-Src-mediated signaling pathway is a mediator of EGFR tyrosine phosphorylation and cell growth in the presence of EGFR TKIs. + + + + 18451158 + + + + + + + + 2008 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Delivery of gemcitabine to tumor cells can be improved by using EGF receptor-targeted immunoliposomes. + + + + 18449514 + + + + + + + + 2008 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HCMV-induced angiogenic response depended on viral binding to and signaling through the beta(1) and beta(3) integrins and the EGFR, via their ability to activate the phosphatidylinositol 3-kinase and the MAPK signaling pathways + + + + 18375753 + + + + + + + + 2008 + 6 + 14 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results demonstrate the physical and functional association of CD9 with epidermal growth factor receptor on MKN-28 cells. + + + + 18247373 + + + + + + + + 2008 + 6 + 7 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Women with two short CA repeats (<19)in EGFR are at a significantly higher risk of breast cancer. Women with short alleles (< 19) had much greater risk of developing cancer before the age of 55. + + + + 18443966 + + + + + + + + 2008 + 6 + 7 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data identify an inhibitory action of AR on EGFR signaling, and support research investigating AR/EGFR antagonism in the treatment of ovarian cancers. + + + + 18374401 + + + + + + + + 2008 + 6 + 7 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases. + + + + 18178562 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The results lead to the conclusion that the interaction between ABD1 and ABD2 and actin during EGF-induced signal transduction, and thus between EGFR and actin, are important in cell activation. + + + + 18396150 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation is associated with Long-lasting complete remission with tyrosine kinase inhibitor in bronchioloalveolar carcinoma + + + + 18379371 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients with T790M EGFR mutation may still response to erlotinib after gefitinib treatment failure + + + + 18379370 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and KRAS mutations occur early during the multistage pathogenesis of peripheral lung adenocarcinomas + + + + 18379350 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HER1 showed significantly increased expression in differentiated thyroid cancer + + + + 18424286 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + 15 Chinese NSCLC patients (62.5%, 15/24) harbored EGFR mutations which included deletion mutations in exon 19 and missense mutations in exon 21. + + + + 18418018 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study found that EGFR high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by immunohistochemistry + + + + 18258923 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection. + + + + 18276593 + + + + + + + + 2008 + 5 + 31 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor overexpression was significantly associated with subsequent metastasis and was found to be an independent prognostic factor for metastasis + + + + 18045646 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Conclude that selected bile acids modulate intestinal permeability via EGF receptor autophosphorylation, occludin dephosphorylation, and rearrangement at the tight junction level. + + + + 18239063 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + cases of primary lung carcinoma were analyzed for correlations between the presence of somatic mutations of the epidermal growth factor receptor (EGFR) gene and the phosphorylation status of EGFR. + + + + 18261621 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells. + + + + 18294142 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + first direct comparison of survival of resected patients with either EGFR or KRAS mutant lung adenocarcinomas compared with those wild type for both genes; EGFR & KRAS mutations define distinct molecular subsets of resected lung adenocarcinoma + + + + 18303429 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Molecular analysis of the primary and a liver metastasis did neither find any EGF-R mutation nor an EGF-R amplification. + + + + 18317076 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations are frequently found in female, nonsmoker patients with adenocarcinoma suggests that some genetic predisposition causes the mutations in the EGFR gene, which result in carcinogenesis and maintenance of lung cancer. + + + + 18317075 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients with advanced NSCLC who are life long never-smokers, those with EGFR TK mutations, and those with bronchioloalveolar cell carcinoma histology seem to have promising efficacy with first-line therapy with EGFR TKIs + + + + 18317074 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Quantitative PCR analysis performed to determine the gene copy number of EGFR relative to that of a control gene (VEST1) did not detect increases in EGFR gene copy number among all patients evaluable for efficacy. + + + + 18317068 + + + + + + + + 2008 + 5 + 24 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data suggest that Ack1 is involved in an early step of EGFR desensitization. + + + + 18262180 + + + + + + + + 2008 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data implicate RME-8 in sorting decisions influencing EGFR at the level of endosomes and point to RME-8 as a potential regulatory target in ErbB2-positive breast cancers. + + + + 18307993 + + + + + + + + 2008 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + KRT17 is upregulated after radical prostatectomy for prostatic neoplasms. + + + + 17448597 + + + + + + + + 2008 + 5 + 17 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Increased expression of erbB3 may play an additional role in non-small-cell lung carcinomas especially in female, nonsmoker, adenocarcinoma, and with EGFR gene mutation. + + + + 17631905 + + + + + + + + 2008 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling. + + + + 18281516 + + + + + + + + 2008 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Nuclear accumulation of EGFR plays a key role in iNOS expression and resultant DNA damage, leading to EBV-mediated Naso-Pharyngeal Carcinoma(NPC). + + + + 18307254 + + + + + + + + 2008 + 5 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The results implicated that activated EGFR molecules associated with clathrin-coated pits but not caveolae at low doses of EGF, whereas they were located in these two domains at high EGF doses. + + + + 18313398 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + MUC5AC is over-expressed in gallstone disease, despite the decrease in the expression of EGFR mRNA. + + + + 18285671 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gene amplification of EGFR was found in 11 lung cancers. Nine of the cancers showed heterogeneous distribution, and amplification was associated with higher histologic grade or invasive growth. + + + + 18381415 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + large-scale database to discriminate the survival impact of EGFR mutations against those of sex and smoking after gefitinib therapy. + + + + 18271929 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation is not associated with cutaneous melanoma + + + + 18227705 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data suggest that ligand release-independent transactivation of EGFR may diversify early TGF-beta signaling and represent a novel pathway leading to TGF-beta-mediated gene expression. + + + + 17637750 + + + + + + + + 2008 + 4 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutation might be a very early event in the pathogenesis of adenocarcinoma of the lung. + + + + 18355544 + + + + + + + + 2008 + 4 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations are associated with a significantly higher response rate and longer duration of response following treatment with EGFR TKIs + + + + 18263768 + + + + + + + + 2008 + 4 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that electric signals might play a role in metastasis of breast cancers by enhancing cell migration through the epidermal growth factor receptor signalling pathway. + + + + 17881501 + + + + + + + + 2008 + 4 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Although EGFR mutations appeared to be partially associated with the early steps of adenocarcinoma development, such mutations may possibly occur randomly even in multiple lesions in a single patient + + + + 17561305 + + + + + + + + 2008 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data indicate that PTHrP contributes to the malignancy of oral cancers downstream of EGFR signaling, and may thus provide a therapeutic target for oral cancer. + + + + 18261460 + + + + + + + + 2008 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data imply that PARP activation following exposure to ionizing radiation is enhanced through EGFR-ERK signaling. + + + + 17295209 + + + + + + + + 2008 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Describe association between EGFR polymorphisms and geftinib treatment outcome and toxicity in non-small-cell lung cancer patients. + + + + 17375033 + + + + + + + + 2008 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Antitumor mechanisms of systemically administered EGFR antisense nucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck is reported. + + + + 18025070 + + + + + + + + 2008 + 4 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression was found in 87.5% (35/40) of the laryngeal primary tumors and 82.5% (33/40) of the corresponding lymph node metastases. There was a good agreement between the primary tumors and the paired metastases regarding EGFR expression. + + + + 18172732 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets. + + + + 17912028 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + amphiregulin-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes + + + + 18045238 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + examination of role of lipids in HER1/HER2-driven progression of human breast epithelial cells towards malignancy + + + + 18211286 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + AC dinucleotide repeat polymorphism in intron 1 of human EGFR may have a role in breast cancer in certain ethnic groups + + + + 18161656 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer. + + + + 18182111 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + siRNA-mediated knockdown is effective in lung adenocarcinomas with EGFR mutation and those with resistance to gefitinib by acquired mutation in EGFR. + + + + 18334834 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy. + + + + 18084281 + + + + + + + + 2008 + 4 + 5 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Genome-wide association study of gene-disease association. (HuGE Navigator) + + + + 18317468 + + + + + + + + HuGENet + + + 1956.18317468 + + + + + HuGENet + + + + + + + 2008 + 4 + 3 + 8 + 25 + 0 + + + + + + + + + 2008 + 4 + 3 + 8 + 27 + 0 + + + + + + + 18 + Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 18379357 + + + + + 18283321 + + + + + + + + HuGENet + + + 1956.18283321 + + + + + HuGENet + + + + + + + 2008 + 4 + 3 + 8 + 25 + 0 + + + + + + + + + 2008 + 4 + 3 + 8 + 27 + 0 + + + + + + + 18 + clinical data suggesting that there could be a subpopulation of metastatic colorectal cancer patients that are more liable to benefit from anti-EGFR monoclonal antibodies--REVIEW + + + + 18154448 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Stimulating human glioblastoma cells with recombinant HGF induces biologically relevant EGFR activation. + + + + 18234969 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma. + + + + 18087285 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations and the administration of EGFR tyrosine kinase inhibitors during Whole-brain radiation therapy (WBRT) were independent predictors of response to WBRT in brain metastases of lung adenocarcinoma. + + + + 18172267 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The population of tumor cells with polysomy of chromosome 7 and EGFR locus correlated significantly with histological grade. High-grade astrocytomas (AAs and GBMs) had elevated fractions of tumor cells with polysomy of chromosome 7 and EGFR locus. + + + + 18240930 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations do not have significant prognostic value in primary resected non-small cell lung cancer + + + + 17917087 + + + + + + + + 2008 + 3 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Amphiregulin is a specific ligand of the EGFR and a potent mitogen for epithelial cells such as breast cancer cell lines. + + + + 17942395 + + + + + + + + 2008 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results highlight a role of P2Y(1)R in EGFR-dependent epithelial cell proliferation. P2Y(1)R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage. + + + + 18057028 + + + + + + + + 2008 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + investigate the status of Her2, EGFR and cyclin D1 in 95 primary breast carcinomas + + + + 18067636 + + + + + + + + 2008 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + TAE226-induced apoptosis in breast cancer cells with overexpressed EGFR. + + + + 17849451 + + + + + + + + 2008 + 3 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study describes activation of EGFR by mutant E-cadherin as a novel mechanism in tumor cells that explains the enhanced motility of tumor cells in the presence of an extracellular mutation of E-cadherin + + + + 18245470 + + + + + + + + 2008 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Neither EGFR nor BMI-1 had significant prognostic impact for basal-like phenotype of breast cancer. + + + + 18269588 + + + + + + + + 2008 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma. + + + + 18208799 + + + + + + + + 2008 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression is present in a majority of hepatocellular carcinomas, suggesting a role for EGFR antagonists in therapy. The increased expression does not correlate with an increase in the EGFR gene copy number. + + + + 18208805 + + + + + + + + 2008 + 3 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) + + + + 17493174 + + + + + + + + HuGENet + + + 1956.17493174 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 18 + 0 + + + + + + + 18 + Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 20015198 + + + + + 17473659 + + + + + + + + HuGENet + + + 1956.17473659 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 18 + 0 + + + + + + + 18 + Observational study of genotype prevalence, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 17285540 + + + + + + + + HuGENet + + + 1956.17285540 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 18 + 0 + + + + + + + 18 + Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 18379359 + + + + + 18349392 + + + + + 18325048 + + + + + 18309947 + + + + + 17148776 + + + + + 16203769 + + + + + + + + HuGENet + + + 1956.16203769 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 17 + 0 + + + + + + + 18 + Observational study of genetic testing. (HuGE Navigator) + + + + 20697298 + + + + + 20459863 + + + + + 20423982 + + + + + 19640859 + + + + + 19366827 + + + + + 19063875 + + + + + 16467085 + + + + + 16199108 + + + + + + + + HuGENet + + + 1956.16199108 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 17 + 0 + + + + + + + 18 + Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 16043828 + + + + + + + + HuGENet + + + 1956.16043828 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 17 + 0 + + + + + + + 18 + Observational study of pharmacogenomic / toxicogenomic and genetic testing. (HuGE Navigator) + + + + 17848912 + + + + + + + + HuGENet + + + 1956.17848912 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 11 + 0 + + + + + + + 18 + Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 21036743 + + + + + 21030498 + + + + + 20884623 + + + + + 20855974 + + + + + 20842128 + + + + + 20808254 + + + + + 20705455 + + + + + 20686428 + + + + + 20644561 + + + + + 20631636 + + + + + 20631634 + + + + + 20630828 + + + + + 20628086 + + + + + 20595147 + + + + + 20552223 + + + + + 20549828 + + + + + 20512075 + + + + + 20502057 + + + + + 20479403 + + + + + 20472851 + + + + + 20458561 + + + + + 20450543 + + + + + 20430469 + + + + + 20398370 + + + + + 20236686 + + + + + 20186026 + + + + + 20159991 + + + + + 20157331 + + + + + 20155428 + + + + + 20100958 + + + + + 20075572 + + + + + 20038314 + + + + + 20035238 + + + + + 19884551 + + + + + 19861461 + + + + + 19854533 + + + + + 19777258 + + + + + 19692684 + + + + + 19672706 + + + + + 19667264 + + + + + 19596959 + + + + + 19543508 + + + + + 19473722 + + + + + 19414683 + + + + + 19371962 + + + + + 19289583 + + + + + 19260752 + + + + + 19247083 + + + + + 19224850 + + + + + 19204207 + + + + + 19201048 + + + + + 19169683 + + + + + 19060236 + + + + + 19057271 + + + + + 19020901 + + + + + 19010870 + + + + + 18985444 + + + + + 18932251 + + + + + 18827605 + + + + + 18827604 + + + + + 18794545 + + + + + 18726117 + + + + + 18676761 + + + + + 18626007 + + + + + 18583573 + + + + + 18559606 + + + + + 18544172 + + + + + 18541260 + + + + + 18458038 + + + + + 18271929 + + + + + 17760255 + + + + + 17192902 + + + + + 17112774 + + + + + 17060486 + + + + + 16818686 + + + + + 16788380 + + + + + 16011858 + + + + + 15837743 + + + + + + + + HuGENet + + + 1956.17760255 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 11 + 0 + + + + + + + 18 + Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) + + + + 20723374 + + + + + 20548248 + + + + + 20418893 + + + + + 20082861 + + + + + 19955396 + + + + + 19843645 + + + + + 19362747 + + + + + 19351817 + + + + + 19170196 + + + + + 19026460 + + + + + 18829487 + + + + + 18478265 + + + + + 17956637 + + + + + 17908966 + + + + + 17760253 + + + + + 17686547 + + + + + 17409930 + + + + + 17387341 + + + + + 17054433 + + + + + 16956694 + + + + + 16567021 + + + + + 16505411 + + + + + + + + HuGENet + + + 1956.17686547 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 11 + 0 + + + + + + + 18 + Observational study of gene-disease association. (HuGE Navigator) + + + + 21070477 + + + + + 21067269 + + + + + 21059816 + + + + + 21057220 + + + + + 21052000 + + + + + 20979823 + + + + + 20975603 + + + + + 20939760 + + + + + 20937558 + + + + + 20937225 + + + + + 20886633 + + + + + 20881644 + + + + + 20824720 + + + + + 20723379 + + + + + 20662834 + + + + + 20661086 + + + + + 20637128 + + + + + 20634891 + + + + + 20627894 + + + + + 20621735 + + + + + 20615575 + + + + + 20589169 + + + + + 20563851 + + + + + 20559151 + + + + + 20559149 + + + + + 20512074 + + + + + 20495538 + + + + + 20473935 + + + + + 20459770 + + + + + 20453000 + + + + + 20446891 + + + + + 20424473 + + + + + 20421815 + + + + + 20409526 + + + + + 20409020 + + + + + 20400478 + + + + + 20381121 + + + + + 20357714 + + + + + 20336783 + + + + + 20303520 + + + + + 20237940 + + + + + 20208477 + + + + + 20197289 + + + + + 20184776 + + + + + 20183914 + + + + + 20150826 + + + + + 20087229 + + + + + 20068085 + + + + + 20049516 + + + + + 20036807 + + + + + 20018398 + + + + + 20008630 + + + + + 19913121 + + + + + 19863329 + + + + + 19860576 + + + + + 19855375 + + + + + 19826477 + + + + + 19812598 + + + + + 19772171 + + + + + 19740513 + + + + + 19726454 + + + + + 19724887 + + + + + 19724844 + + + + + 19723643 + + + + + 19706809 + + + + + 19704257 + + + + + 19692168 + + + + + 19650855 + + + + + 19643949 + + + + + 19636371 + + + + + 19625176 + + + + + 19609951 + + + + + 19590514 + + + + + 19584155 + + + + + 19563658 + + + + + 19525979 + + + + + 19517135 + + + + + 19477549 + + + + + 19453261 + + + + + 19381876 + + + + + 19369630 + + + + + 19357847 + + + + + 19353773 + + + + + 19353596 + + + + + 19284481 + + + + + 19270482 + + + + + 19265688 + + + + + 19255323 + + + + + 19253367 + + + + + 19238633 + + + + + 19234440 + + + + + 19190167 + + + + + 19179548 + + + + + 19141999 + + + + + 19130320 + + + + + 19096302 + + + + + 19096301 + + + + + 19094482 + + + + + 19088172 + + + + + 19086053 + + + + + 19074885 + + + + + 19064969 + + + + + 19058870 + + + + + 19047118 + + + + + 19002495 + + + + + 18950515 + + + + + 18949739 + + + + + 18946768 + + + + + 18722874 + + + + + 18683191 + + + + + 18676680 + + + + + 18664296 + + + + + 18594528 + + + + + 18594314 + + + + + 18593984 + + + + + 18571764 + + + + + 18543225 + + + + + 18528899 + + + + + 18508816 + + + + + 18464244 + + + + + 18450321 + + + + + 18448998 + + + + + 18443966 + + + + + 18418018 + + + + + 18413774 + + + + + 18261621 + + + + + 18161656 + + + + + 17941001 + + + + + 17932690 + + + + + 17912028 + + + + + 17852426 + + + + + 17845757 + + + + + 17644807 + + + + + 17580276 + + + + + 17575224 + + + + + 17538160 + + + + + 17504988 + + + + + 17487277 + + + + + 17453292 + + + + + 17431338 + + + + + 17409862 + + + + + 17354229 + + + + + 17337084 + + + + + 17321325 + + + + + 17303584 + + + + + 17285735 + + + + + 17227303 + + + + + 17224267 + + + + + 17219440 + + + + + 17175376 + + + + + 17092854 + + + + + 16552419 + + + + + 16461080 + + + + + 16449241 + + + + + 16376942 + + + + + 16353158 + + + + + 16344724 + + + + + 16243431 + + + + + 16140420 + + + + + 16052218 + + + + + 16032426 + + + + + 16030116 + + + + + 16018936 + + + + + 16003726 + + + + + 16002952 + + + + + 15998907 + + + + + 15829495 + + + + + 15540509 + + + + + 15063762 + + + + + 12719950 + + + + + 12653106 + + + + + 11504770 + + + + + + + + HuGENet + + + 1956.17575224 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 11 + 0 + + + + + + + 18 + Observational study of genotype prevalence. (HuGE Navigator) + + + + 20565774 + + + + + 17949425 + + + + + 17904685 + + + + + 17548322 + + + + + 17455987 + + + + + 17102595 + + + + + 16397024 + + + + + 16324836 + + + + + 16240846 + + + + + 12768436 + + + + + 12631599 + + + + + + + + HuGENet + + + 1956.17548322 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 10 + 0 + + + + + + + 18 + Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) + + + + 18202784 + + + + + 18186271 + + + + + 18176089 + + + + + 17875767 + + + + + 17761979 + + + + + 17713473 + + + + + 17661145 + + + + + 17626639 + + + + + 17610986 + + + + + 17607119 + + + + + 17597605 + + + + + 17487844 + + + + + 17473658 + + + + + 17429313 + + + + + 17409866 + + + + + 17409827 + + + + + 17375033 + + + + + 17368623 + + + + + 17106442 + + + + + 16757132 + + + + + 16503086 + + + + + 16467097 + + + + + 16198442 + + + + + 16152581 + + + + + 16098254 + + + + + 15956035 + + + + + 15738541 + + + + + 15710947 + + + + + 15701846 + + + + + + + + HuGENet + + + 1956.16503086 + + + + + HuGENet + + + + + + + 2008 + 3 + 13 + 8 + 43 + 0 + + + + + + + + + 2008 + 3 + 13 + 9 + 0 + 0 + + + + + + + 18 + EGFR structural alterations are rare in gastric carcinoma, but whenever present, it leads to tumour growth. + + + + 18199332 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings implicate the ErbB pathway in vestibular schwannoma growth + + + + 18199957 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation. + + + + 18028876 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CONCLUSION: [111In]DTPA-hEGF is translocated to the nucleus of BC cells complexed with EGFR and importin beta1. + + + + 17998090 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR insertion mutation in exon 20 could not be ignored from Japanese lung cancers + + + + 17686547 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR activation is the cause of both hyperplastic growth and VDR reduction in secondary parathyroidism hyperplasia + + + + 18216322 + + + + + + + + 2008 + 3 + 10 + 12 + 11 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The presence of neuroendocrine cells may have an effect on the expression of TGF-alpha and EGFR in gastric adenocarcinoma, and the autocrine mechanism between TGF-alpha and EGFR plays an important role in the prognosis of gastric carcinoma. + + + + 17922051 + + + + + + + + 2008 + 2 + 23 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell line genetic heterogeneity and/or multiple determinants modulate the role played by EGFR/HER2 in regulating cell proliferation. + + + + 18199554 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This is the first time EGFR expression has been tracked meaningfully and developmentally from the normal condition through disease progression using in vitro, xenograft, and matched normal and tumor samples. + + + + 17989321 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations in carcinogenesis of lung adenocarcinoma: distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma + + + + 18186961 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + AP-1 and NF-kappaB transcription factors are activated and EGF-R is expressed in these cells and associated with COX-2 and VEGF production. + + + + 18032824 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Amplifications within regulatory sequences of egfr are associated with the expression of eps15 and caveolin-1; EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK seems to present a major molecular pathway in progression of breast phyllodes tumours. + + + + 18032821 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment. + + + + 18060032 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + heterozygous and synonymous transition of the EGFR gene and low EGFR expression levels of mRNA and protein in squamous cell carcinomas of the head and neck (SCCHN) may be reliable predictors of high sensitivity in SCCHN patients to gefitinib. + + + + 18097577 + + + + + + + + 2008 + 2 + 16 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + alterations within the tyrosine kinase domain and expression of EGFRvIII are rare events in bladder cancer + + + + 16899617 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This study demonstrates that ADV-Avi/biotin-PEG-EGF construct systems can be applied for cell-specific delivery of ADV with simultaneously reducing innate immune responses. + + + + 18083120 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Patients with non-small cell lung cancer and EGFR exon 19 deletions have a longer survival following treatment with gefitinib or erlotinib compared with those with the L858R mutation + + + + 16818686 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Inhibitory activity of cetuximab on epidermal growth factor receptor mutations is associated with non small cell lung cancers + + + + 17913857 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations were frequently found in lung adenocarcinoma with ground-glass opacity (GGO) on High-Resolution CT in this study. + + + + 18089646 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + oncogenic EGFR and c-Met have roles in pathways mediating drug response + + + + 18180459 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine. + + + + 17805209 + + + + + + + + 2008 + 2 + 9 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The serum CEA level appears to be closely associated with the presence of EGFR gene mutations in patients with pulmonary adenocarcinomas. + + + + 17941001 + + + + + + + + 2008 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression, mutations, polymorphisms, and gene amplification contribute to to the pharmacodynamics of EGFR inhibitors. + + + + 18006781 + + + + + + + + 2008 + 2 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR may play an important role in the pathogenesis and phenotype of Congenital cystic airway malformation/congenital pulmonary airway malformation. + + + + 17714760 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR in lung adenocarcinomas with components of BAC histology correlate with never-smoker status and improved overall survival and disease-free interval. + + + + 18154814 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + activating mutations in the TKD domain of EGFR contribute to radiosensitivity of non-small-cell lung carcinoma + + + + 17018617 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + GM3 has an effect on kinase associated with EGFR + + + + 17638075 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The clinical relevance of 'other' EGFR mutation variants remains uncertain and requires further assessment. + + + + 18000506 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Immunohistochemical profiling of colorectal cancer seems to be a promising approach, not only to define prognostic impact, but also to detail proliferation-related molecular interplays between EGFr and Cox-2 pathways. + + + + 15923435 + + + + + + + + 2008 + 1 + 26 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + MET amplification occurs independently of EGFR(T790M) mutations in lung adenocarcinoma + + + + 18093943 + + + + + + + + 2008 + 1 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + development of PF00299804 as treatment for cancers with mutations and/or amplifications of ERBB family members. + + + + 18089823 + + + + + + + + 2008 + 1 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR immunoreactivity with basal cytoplasmic pattern was exclusively seen in terminal respiratory unit type lung adenocarcinoma and a subset of these cases was seen with EGFR mutations in the responders to EGFR inhibitor therapy + + + + 17721266 + + + + + + + + 2008 + 1 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation. + + + + 17655843 + + + + + + + + 2008 + 1 + 19 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + examination of rate of association reactions between Grb2 and epidermal growth factor receptor + + + + 17991782 + + + + + + + + 2008 + 1 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that the EGFR polymorphisms, particularly the 181945C>T polymorphism, could be used as markers for the genetic susceptibility to lung cancer. + + + + 17956637 + + + + + + + + 2008 + 1 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. + + + + 17974918 + + + + + + + + 2008 + 1 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells + + + + 17918184 + + + + + + + + 2008 + 1 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + curcumin and FOLFOX work through attenuation of the EGFR and IGF-1R signaling pathways + + + + 17918158 + + + + + + + + 2008 + 1 + 12 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + we have shown no expression of ErbB-1 in vestibular schwannomas + + + + 17964790 + + + + + + + + 2008 + 1 + 5 + 14 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Wnt and epidermal growth factor receptor signaling pathways are altered through aberrant methylation and mutation in non small cell lung cancer + + + + 17947472 + + + + + + + + 2007 + 12 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CISH (chromogenic in situ hybridization) is an alternative assay to FISH in determining EGFR copy number. + + + + 17673923 + + + + + + + + 2007 + 12 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation than in lung cancer without EGFR mutation + + + + 17922974 + + + + + + + + 2007 + 12 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Up-regulation of the EGFR cascade may have an important role regarding mucus production in the sinus mucosa of patients with CRS and CRS/NP associated with hyperplasia and metaplasia of epithelial goblet cells + + + + 18025312 + + + + + + + + 2007 + 12 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + sex and smoking status could influence the EGFR mutational spectrum + + + + 17908966 + + + + + + + + 2007 + 12 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + induction of p50/p50/Bcl-3 complexes by latent membrane protein 1 (LMP1) C-terminal activating region 1 mediates LMP1-induced epidermal growth factor receptor upregulation + + + + 17881446 + + + + + + + + 2007 + 12 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + delE746-A750+L858R double activating EGFR mutations exist in Chinese non-small cell lung cancer patients and both locate on the same allele + + + + 17537621 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands + + + + 17823122 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR polymorphisms may be associated with clinical outcome in patients treated with chemoradiation. + + + + 17112774 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results suggest extracellular missense mutations as a novel mechanism for oncogenic EGFR activation and may help identify patients who can benefit from EGFR kinase inhibitors for treatment of glioblastoma. + + + + 17177598 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Increased EGFR gene copy number and elevated EGF levels are present in a significant proportion of pancreatic cancer patients, and this may reflect increased EGFR pathway dependence with improved sensitivity to EGFR-targeted therapy. + + + + 17950068 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Regarding EGFR, no specific mutation was detected in five of the six patients with lung cancer whereas one female patient who had never smoked had a missense mutation. + + + + 17784875 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + No previouly described somatic EGFR mutations were found in head and neck squamous cell carcinoma DNA, but other DNA sequence variations were found in 9 of 31 patients. Activating EGFR mutations seem to be a rare event in Spanish HNSCC patients. + + + + 17962724 + + + + + + + + 2007 + 12 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC + + + + 17525275 + + + + + + + + 2007 + 12 + 13 + 12 + 42 + 0 + + + + + + + + + 2007 + 12 + 13 + 16 + 9 + 0 + + + + + + + 18 + study investigated EGFR protein expression & gene mutations in exons 18, 19 and 21 in 40 renal angiomyolipomas (AML); no EGFR gene mutations of TK domain were detected and strong immunostaining was found in 5% of the renal AML cases + + + + 17685929 + + + + + + + + 2007 + 12 + 8 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study found that EGFR down-regulation was impaired in two non-small cell lung cancers with EGFR tyrosine kinase domain mutations; the mutant receptors were poorly ubiquitylated and exhibited decreased association with the ubiquitin ligase Cbl + + + + 17699773 + + + + + + + + 2007 + 12 + 8 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signalling plays a central role in cyclooxygenase-2 induction by transforming growth factor-beta 1 in human bronchial epithelial cells. + + + + 17600311 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell + + + + 17631646 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR somatic mutations directly influence both erlotinib cancer cell sensitivity and cellular transformation. + + + + 16912195 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + upregulation of EGFR expression in a few warty and basaloid HG-VIN cases and in many SCCs of the vulva. + + + + 17885502 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling + + + + 17486068 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Reduction of sperm motility by tryptase through the PAR-2 receptor involves epidermal growth factor receptor pathways. + + + + 17712488 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + T790M mutation is sometimes present in a minor population of tumor cells during the development of non-small cell lung cancer. + + + + 16912157 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities. + + + + 17652160 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HGF induces transactivation of the EGFR in epithelial cells, and this is a prerequisite for induction of full motility. + + + + 17643426 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In Chinese lung cancer patients, a low number of CA repeats in intron 1 of the EGF receptor gene is associated with a better clinical outcome during therapy with gefitinib. + + + + 17597605 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas. + + + + 17972518 + + + + + + + + 2007 + 12 + 1 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation + + + + 17907599 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR. + + + + 17870017 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Amplification of the EGFR gene and polysomy 7 are frequent alterations in primary melanomas and are associated with bad prognosis + + + + 17594688 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In a novel culture system normal human adult melanocytes expressed both EGF receptor (EGFR) mRNA and protein and EGF showed a dose dependent mitogenic effect on the cells + + + + 17334773 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients. + + + + 17508947 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance. + + + + 17804738 + + + + + + + + 2007 + 11 + 10 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation and gene amplification is asociated with clear cell sarcoma of the kidney + + + + 17646270 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking + + + + 17575133 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + No correlation between epidermal growth factor receptor protein overexpression and epidermal growth factor receptor gene amplification in gastrointestinal stromal tumors. + + + + 17643098 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Fluorescence in situ hybridization/immunohistochemistry analysis of EGFR may be a useful ancillary tool to classify difficult cytology cases and inform clinicians arranging targeted chemotherapy. + + + + 17643093 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with astrocytic tumor pathogenesis and progression + + + + 17822324 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Shorter EGFR intron 1 CA repeat length is associated with worse pancreatic cancer clinical prognosis and in vitro response to erlotinib. + + + + 17453292 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas. + + + + 17618248 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A subset of pancreatic ductal adenocarcinomas is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence). + + + + 16795991 + + + + + + + + 2007 + 10 + 27 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + It seems that continued EGFR tyrosine kinase inhibition may be beneficial to EGFR-mutant lung cancers. + + + + 17566601 + + + + + + + + 2007 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + OSU-03012 prevents YBX1 from inducing EGFR. + + + + 17595327 + + + + + + + + 2007 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings suggest a mechanism by which filopodia detect the presence and concentration of effector molecules far from the cell body and mediate cellular responses via directed transport of activated receptors. + + + + 16103229 + + + + + + + + 2007 + 10 + 20 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + When combining thymidylate synthase and epidermal growth factor A61G genotype analysis, a small subgroup with a complete pathologic response rate of 100 percent was identified. + + + + 17661145 + + + + + + + + 2007 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. + + + + 17516110 + + + + + + + + 2007 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38 + + + + 17548351 + + + + + + + + 2007 + 10 + 13 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR/Akt pathway mitigated G2/M arrest in human HaCaT keratinocytes and normal human keratinocytes treated with low doses of UVA irradiation. + + + + 17495959 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression. + + + + 17622245 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the long lifetime of EGFRvIII, mutant variant of EGFR is caused by inefficient internalization and impaired sorting to lysosomes due to lack of effective ubiquitinylation. + + + + 17372273 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In NSCLC cases with wt- or mutant KRAS, downregulation of EGFR expression was a rare event although upregulation in bone metastases was observed more frequently in wt K-RAS cases. + + + + 17607370 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the R497K polymorphism of the EGFR could be a key determinant for reduced tumor recurrence and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma + + + + 17575224 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation can easily be detected in metastatic lymph nodes sampled by EBUS-TBNA. + + + + 17573511 + + + + + + + + 2007 + 10 + 6 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Final outcome of bladder cancer patients with high HER1- and HER2-expressing tumors depends on the expression of HER3 AND HER4. + + + + 16685269 + + + + + + + + 2006 + 8 + 19 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Adenin/guanine polymorphisms are not associated with endometrial cancer in a Japanese population. + + + + 17644807 + + + + + + + + 2007 + 9 + 29 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Frequencies of EGFR mutations were similar in both the alveolar and bronchial types of lung cancer + + + + 17459062 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation + + + + 17545148 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + activating phosphorylation site on the c-Met receptor was found to be highly responsive to EGFRvIII levels, indicating cross-activation of the c-Met receptor tyrosine kinase by EGFRvIII + + + + 17646646 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In bronchioalveolar carcinoma/adenocarcinoma with bronchioalveolar features mucinous differentiation was significantly correlated with the absence of EGFR mutation and presence of KRAS mutation. + + + + 17591931 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations were therefore significantly associated with a better PFS in the first-line cytotoxic chemotherapy regimens. + + + + 17607119 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term. + + + + 17650314 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + acquired resistance against both erlotinib, as well as gefitinib was most likely a result of tumor cells acquiring the T790M mutations + + + + 17649787 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + it is suggested that atypical adenomatous hyperplasia (AAH) could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer + + + + 17534846 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib. + + + + 17626639 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer. + + + + 17581404 + + + + + + + + 2007 + 9 + 22 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation. + + + + 17237147 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells + + + + 17525128 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation + + + + 17671201 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Decreased intratumoral EGFR expression and the absence of activated EGFR suggests that EGFR inhibition might not be an ideal target for antibody therapy. + + + + 17611648 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported. + + + + 17390041 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Two somatic alterations (E829E and R831C) were identified in the cytoplasmic domain of the EGFR gene in 1 of 10 osteosarcoma samples. + + + + 17509661 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation status influenced the effect of adjuvant chemotherapy with uracil-tegafur. + + + + 17761979 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Shiga toxin trafficking to the Golgi is controlled by several Rab GAPs and their target Rabs and this process is discrete from ligand-induced EGFR trafficking. RabGAP-5 was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin + + + + 17562788 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The number of dinucleotide repeats in this receptor identifies a possible susceptible population to lung cancer. + + + + 17219440 + + + + + + + + 2007 + 9 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk. + + + + 17475774 + + + + + + + + 2007 + 9 + 4 + 16 + 3 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization + + + + 12686539 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the acceleration of EBV LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma + + + + 15652339 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer. + + + + 15921680 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules. + + + + 15920544 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Seasonal allergic rhinitis subject showed significant elevation in EGFR expression, consistent with the observation of mucus hypersecretion in allergic rhinitis. + + + + 12757445 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Increased levels of EGFR were significantly associated with adult soft tissue sarcomas + + + + 15772959 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results indicate that epidermal growth factor (EGF) receptors can form a ligand-independent inactive dimer and that receptor dimerization and activation are mechanistically distinct and separable events. + + + + 12134089 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling. + + + + 12134064 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The optimization and specification of therapeutic approaches based on erbB-receptor targeting requires to account for EGFR coexpression as well as the potential presence of erbB-receptor relevant growth factors. + + + + 15748904 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that the secreted Hsp70 mediates the cross-communication of Toll like receptor and epidermal growth factor receptor signaling systems in A431 cells. + + + + 17126326 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of the EGFR is associated with astrocytomas + + + + 17285230 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor D761Y mutation has a role in response to tyrosine kinase inhibitors + + + + 17545553 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ganglioside GM3 inhibits integrin-induced, ligand-independent epidermal growth factor receptor phosphorylation (cross-talk) through suppression of Src family kinase and phosphatidylinositol 3-kinase signaling + + + + 14512423 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma + + + + 16203769 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor has a role in response to gefitinib treatment in patients with non-small cell lung cancer + + + + 16870303 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Conventional PKC isoforms, especially PKCalpha, mediate feedback inhibition of G-protein-coupled receptor -induced EGFR transactivation. + + + + 17307332 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor traffic is disrupted by farnesyltransferase inhibitors through modulation of the RhoB GTPase + + + + 15226397 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding. + + + + 17381163 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity. + + + + 17462600 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Potentially interesting value of the serum levels of sEGFR and EGF, especially when combined, as markers for non-small cell lung cancer and head and neck cancer. + + + + 17453000 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HDL blocks neuroblastoma differentiation by inhibition of EGFR + + + + 15735700 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway + + + + 15735691 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Decorin causes EGFR internalization via caveolae + + + + 15994311 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Differential EGFR patterns by interphase cytogenetics in malignant peripheral nerve sheath tumor and morphologically similar spindle cell neoplasms. + + + + 12152785 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway. + + + + 12444032 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of the invasive phenotype in breast epithelial cells requires increased EGF receptor signaling, involving both PI 3-kinase and Erk 1,2 activities, which leads to enhanced secretion of MMP-9 and transcription of invasion-related genes. + + + + 12487410 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells + + + + 15798095 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells + + + + 16242075 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The frequency of CA allele combinations was assessed in healthy women from Poland; results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation. + + + + 16240846 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR positivity was observed in all the cases (100%) of benign prostatic hypertrophy (BPH) and prostatic intraepithelial neoplasia (PIN) and in only 10 cases (28.5%) of prostatic carcinoma. + + + + 17183836 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors. + + + + 17349623 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + effects of receptor-selective retinoid ligands on EGFR-associated signal transduction + + + + 11788593 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas. + + + + 15248827 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF signalling amplification is induced by dynamic clustering of EGFR + + + + 15485674 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + activation regulates mutation and epidermal growth factor receptor activation regulates vascular endothelial growth factor mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. + + + + 12517803 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer + + + + 16305343 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signaling pathway negatively regulates prostate specific antigen expression which may be induced by the alteration of androgen expression via the PI3K-Akt pathway in LNCaP C-81 cells + + + + 16472761 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation. + + + + 16569667 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. + + + + 16923119 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway. + + + + 17053785 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44, whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3. + + + + 17196962 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor mutations are associated with adenosquamous carcinoma of the lung + + + + 17186532 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings unmask an EGF-sensitive checkpoint, helping to understand the link between sustained EGFR signalling, proliferation and the acquisition of a radioresistant phenotype in cancer cells. + + + + 17157295 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + somatic alterations in p53 and EGFR have roles in progression of primary lung cancer + + + + 17200338 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation. + + + + 12354760 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. + + + + 14507652 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy. + + + + 15042583 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR physically interacts with signal transducers and activators of transcription 3 in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase. + + + + 15950906 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology + + + + 11897506 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutual interaction of EGFR with c-Src is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review. + + + + 12456372 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor down-regulation by UVA may play an important role in the execution of the cell suicide program by attenuating its anti-apoptotic function + + + + 12930839 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Ligand-induced EGFR degradation is preceded by proteasome-dependent EGFR de-ubiquitination. + + + + 12829707 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our findings suggest that extracellular H(2)O(2) generated by EGFR-ligand interaction permeates the plasma membrane and inhibits EGFR-associated tyrosine phosphatase activity. + + + + 15982634 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The majority of oral squamous cell carcinomas highly express EGFR and p-EGFR, and a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. + + + + 16799709 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PTEN tumor-suppressor protein has a role in response to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma + + + + 17255257 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Calmodulin binds to the EGFR + + + + 11853560 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + determination of decorin binding site + + + + 12105206 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton. + + + + 15389641 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mitogenic effects of gastrin-releasing peptide in head and neck squamous cells are mediated by activation of EGFR. + + + + 13679857 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results indicate that the EGFR signaling pathway is involved in urothelial regeneration. + + + + 13679441 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF + + + + 14978035 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Frequent EGFR mutations is associated with brain metastases of lung adenocarcinoma + + + + 16642476 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF + + + + 16687414 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results describe a relationship between the effects of epidermal growth factor (EGF) on cell proliferation and levels of EGF receptor expression in a cell line expressing different levels of EGFR caused by different concentrations of EGF treatment. + + + + 16750403 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation. + + + + 16785991 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings are consistent with a model in which ErbB1 expression increases during development of the androgen-independent state. Drugs targeted toward ErbB signaling could be of therapeutic relevance in the management of advanced prostatic carcinoma. + + + + 16741920 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is required for UVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin. + + + + 16936259 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway + + + + 16984414 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Rin1 regulates EGFR degradation in cooperation with STAM + + + + 17403676 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length. + + + + 11953893 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data indicate that growth hormone, by activating extracellular signal related kinases, can modulate epidermal growth factor-induced epidermal growth factor receptor trafficking and signaling + + + + 12642595 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR downregulation is inhibited by Sprouty2 targeting both the Cbl and CIN85 pathways. + + + + 15962011 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + blocking of ubiquitination by inhibiting Src family kinases + + + + 11994282 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Intensive staining of EGF-R is associated with invasive tumours of bladder + + + + 15082004 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that activation of ADAM-17 results in discrete cellular responses, while G protein-coupled receptor agonists promote activation of the Ras/MAPK pathway and cell proliferation via the epidermal growth factor receptor. + + + + 15337756 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data suggest that mutations of epidermal growth factor receptor (EGFR) and K-RAS genes might separately, but not cooperatively, contribute to lung adenocarcinoma pathogenesis + + + + 15815931 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The expression of this protein was not different in the clone cell variants or the A431 parental line. + + + + 12722480 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors + + + + 12388817 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors + + + + 14607699 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of proteins that bind to and interact with EGFR + + + + 16738552 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and K-ras mutations may have a role in progression of resected non-small-cell lung cancer + + + + 17596643 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF-R fate is controlled by a checkpoint downstream of receptor ubiquitination whose regulation by the Cbl RF tail may require Sprouty2 degradation. + + + + 16246327 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR. + + + + 16373414 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin and increased epidermal growth factor receptor (EGFR) endocytosis at physiological EGF concentrations. + + + + 16622417 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + involvement urokinase plasminogen activator secretion and cell motility in breast cancer cells + + + + 14704150 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the adhesion-dependent activation of EGF receptor signaling is promoted by L1-type CAMs in vitro and in vivo + + + + 14718570 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Trypsin exerts robust trophic action on colon cancer cells and underline the critical role of EGF-R transactivation. + + + + 15010475 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Human leukocyte elastase induces keratinocyte proliferation by proteolytic activation of an EGFR signaling cascade involving TGF-alpha. + + + + 15245434 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + heterogeneity in the density of EGFR due to localization in certain regions of the plasma membrane, which has been experimentally reported, can also lead to concave up shape of the Scatchard plot of the EGF binding on EGFR + + + + 15896781 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These findings reveal a new role for EGFR in the postnatal brain and open new avenues to optimize cell engraftment for brain repair. + + + + 16319309 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, in addition to E2F1, target sites induce B-Myb promoter + + + + 16299810 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR). + + + + 11751923 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + novel mechanism of EGFR internalization that does not require ligand binding, receptor kinase activity, or ubiquitylation and does not direct the receptor into a degradative pathway + + + + 12006662 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + regulation of LMP1 on the nuclear translocation of EGFR is critical for the process of nasopharyngeal carcinoma + + + + 15524283 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy. + + + + 16098254 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy + + + + 15447984 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + endosomal epidermal growth factor receptor stimulates cell growth + + + + 12897150 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression was associated with improved survival. + + + + 16010411 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells + + + + 15967120 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Antibodies from naive human scFv (single-chain Fv) phage display libraries provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family. + + + + 16398612 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a wide spectrum of somatic EGFR TK mutations reporting a relatively high incidence (15%) in NSCLC patients of Greek and Czech origin. + + + + 16567021 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + An EGF mutant, designated WVR/EGF/IADIQ, gained high affinity for ErbB3 & showed concomitant ErbB3 activation through ErbB2.ErbB3 heterodimers similar to the natural ErbB3 ligand NRG1beta, while the capacity to bind & activate ErbB1 was fully maintained. + + + + 16584205 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested + + + + 16641105 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These data demonstrate that sterile wounding initiates an innate immune response through activation of the epidermal growth factor receptor that increases resistance to overt infection and microbial colonization. + + + + 16778986 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results demonstrate that both clathrin-positive and clathrin-negative electron dense coats exist on endosomes and are involved in endosomal sorting of the EGFR. + + + + 16859684 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR. + + + + 17182860 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression in small cell carcinoma of the urinary bladder does not seem to be caused by gene amplification + + + + 17289890 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression. + + + + 17514628 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor in mice is strongly dependent on genetic background. + + + + 15342520 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element. + + + + 15828871 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + fibrin can support the wound healing process of the epidermis via the TGF-alpha/EGF-R pathway + + + + 16082153 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and zinc-induced Ras activation + + + + 11983694 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data demonstrate that prostaglandin E2 transactivates EGFR and triggers mitogenic signaling in gastric epithelial and colon cancer cells as well as in rat gastric mucosa in vivo + + + + 11875501 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations in exon 21 are early events in small bronchiolalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types. + + + + 17505415 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Infection of AGS cells by H. pylori significantly increased EGFR mRNA and protein levels. + + + + 17538889 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + targeting in cancer, involved in apoptosis (REVIEW) + + + + 12517767 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR regulation by E-cadherin was associated with complex formation between EGFR and E-cadherin that depended on the extracellular domain of E-cadherin but was independent of beta-catenin binding or p120-catenin binding + + + + 15057284 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor activity on fertilization capacity of testicular harvested spermatozoa + + + + 11966576 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + androgens promote an increase in the activity of the epidermal growth factor (EGF)-network by increasing ErbB1 levels, and this activity of is essential for androgen-induced proliferation and survival of the prostate cancer LNCaP cell line. + + + + 12746839 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + carboxyl-terminal mutation of the epidermal growth factor receptor alters tyrosine kinase activity and substrate specificity + + + + 12746449 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results demonstrate that tamoxifen resistant MCF-7 cell growth is mediated by the autocrine release and action of an epidermal growth factor receptor-specific ligand inducing preferential epidermal growth factor receptor/c-erbB2 dimerization + + + + 12586780 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Exogenous OPN increased EGFR mRNA expression, as well as EGFR kinase activity. Inhibition of EGFR significantly impaired the cell migration response to OPN. + + + + 12606946 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Human colon carcinoma cells that overexpress cyclooxygenase exhibit growth stimulation and induction of this protein. + + + + 12664617 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + sorting of endocytosed epidermal growth factor receptor into the degradation pathway requires both its kinase activity and actin-binding domain + + + + 14702346 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + SHP-2/Gab1 association is critical for linking EGFR to NF-kappaB transcriptional activity via the PI3-kinase/Akt signaling axis in glioblastoma cells + + + + 14701753 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data explain how thrombin exerts robust trophic action on colon cancer cells and underline the critical role of EGFR transactivation + + + + 15383630 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results describe the role of epidermal growth factor receptor regulation in antiapoptosis, cell migration, and cell proliferation. + + + + 15364923 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Egfr Wa5 is a novel ENU-induced antimorphic allele caused by a kinase-dead receptor acting as a dominant negative + + + + 15366372 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HER2-mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2-mediated amplification of epidermal growth factor-induced ERK signaling + + + + 15572377 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells + + + + 15618223 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Tyr-992 and Tyr-1173 are required for phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2 + + + + 15708852 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that expression of epidermal growth factor receptors (EGFR) in transgenic mouse Schwann cells elicited features of neurofibromas, supporting the relevance of EGFR to peripheral nerve tumor formation. + + + + 15652750 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + overexpression of the active form of the small GTPase RhoA induces the activation of Epidermal Growth Factor Receptor and promotes cell motility + + + + 15963982 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Existence of unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II, acting through IGF-IR, regulates basal and ligand-activated EGFR signaling and cell proliferation in a c-SRC-dependent manner in tamoxifen-resistant breast cancer. + + + + 16037379 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Using the LightCycler PCR assay, the EGFR L858R mutation status might correlate with gender, pathologic subtypes, and gefitinib sensitivity of lung cancers. + + + + 15837743 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show that the juxtamembrane region of the epidermal growth factor receptor is necessary for accurate polarized expression of the native molecule. + + + + 12161422 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Loss of PTEN/MMAC1/TEP in tumor cells expression this protein counteracts the antitumor action of EGFR tyrosine kinase inhibitors. + + + + 12743604 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes + + + + 15039424 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in normal keratinocytes + + + + 15254267 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in the tyrosine kinase domain of the epidermal growth factor receptor is associated with non-small cell lung cancer + + + + 15788655 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings suggest that overexpression of EGFR in glioblastomas in Chinese patients may be associated closely with the patients age but not with the tumors' pathological pathway. + + + + 16151725 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR was significantly correlated with depth of invasion of the tumor + + + + 16161046 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations may contribute to the development of bronchioloaveolar carcinoma and are one of the early genetic alterations in multistage carcinogenic processes of lung adenocarcinoma + + + + 16353158 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer + + + + 16401639 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data suggest the possibility of a mechanically activated epidermal growth factor receptor (EGFR) autocrine feedback loop involving selected EGFR ligands. + + + + 15705969 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Up-regulation of EGFR is associated with renal cell carcinoma + + + + 14520461 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression status in lung cancer correlates with its mutation. + + + + 16226114 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mediation of synergism with c-src by STAT5b + + + + 12429742 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma + + + + 15749523 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Findings provide evidence that STAT 3 signal activity in head and neck carcinomas, which is partially responsible for proliferative activity, can be controlled via the EGFR. + + + + 15736426 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + determination of whether G protein-coupled receptor kinase-2 can phosphorylate and desensitize epidermal growth factor receptor + + + + 12381737 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data indicate that phospholipase A2 downregulates the EGF receptor-mediated intracellular signal transduction that may be mediated by arachidonic acid and/or ceramide. + + + + 12243760 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that stimulation of epidermal growth factor receptors differentially regulates chemokine expression in keratinocytes. + + + + 12819035 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Syk acts a negative control element of EGFR signalling. + + + + 15337524 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma + + + + 12223352 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. + + + + 12782602 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the relationship between the egfr polymorphism and breast cancer risk + + + + 14729599 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5. + + + + 15590694 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor expression was elevated in the prefrontal cortex in schizophrenic + + + + 12192610 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor negatively regulates intracellular kinase activation in the absence of ligand + + + + 12795333 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HEGFR was expressed in the subventricular zone embryologically + + + + 12794748 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High EGFR gene copy number identified by FISH may be an effective molecular predictor for gefitinib efficacy in advanced NSCLC. + + + + 15870435 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Chromogenic in situ hybridization analysis and morphology identified 22 small cell (SCGBM) and 22 non-small cell glioblastoma (NSCGBM), and 12 cases of a mixed phenotype. + + + + 16033132 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overall, these data suggest that GRK2 has a regulatory role in EGF-induced ERK/MAPK activation. + + + + 16077899 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + simulation results show the formation of a channel under Thr766 following the movement of the side chain of Gln767 away from the hinge in EGFR + + + + 16184431 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Intratumoral variation of epidermal growth factor receptor (EGFR) expression in glioblastoma multiforme was examined, and radionuclide labelled substances that bind specifically to EGFR were considered for intracavitary therapy. + + + + 16200342 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The cytoplasmic overexpression of EGFr plays a significant role in the progression of pancreatic ductal adenocarcinoma, especially in the invasion and acquisition of aggressive clinical behavior. + + + + 15211117 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that human sprouty2 potentiates epidermal growth factor receptor signalling by specifically intercepting c-Cbl-mediated effects on receptor down-regulation. + + + + 12234920 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, DI, and the diploid are valuable targets for judging metastasis and recurrence of gastric cancer before and after operation. + + + + 12479108 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of EGFR seems to play an important role in metastasis, especially liver metastasis and recurrence of pancreatic cancer. + + + + 12579331 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + lysosomal degradation by adenovirus E3 RIDalpha protein dependent on specific domains + + + + 14557654 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness + + + + 15623594 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + stimulation of the EGFR pathway is one mechanism by which the bone marrow microenvironment may contribute to the growth and survival of B-cell acute leukemia + + + + 15701973 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation + + + + 15701846 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results show that EGFR are present on normal human melanocytes + + + + 16098054 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II + + + + 16126727 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that epidermal growth factor receptor dileucine motif 679-LL is an alpha-helical stabilizing motif that regulates a predominant step during lysosomal sorting, involving intracellular retention under both sub-saturating and saturating conditions. + + + + 16105874 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the effect of interleukin-8 (IL-8) induced by H. pylori infection on EGFR transactivation and epithelial cell growth + + + + 16240219 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Ubiquitination of EGFR at late stages of endocytosis was significantly lower than that in control cells. Highly ubiquitinated forms of EGFR demonstrated more sensitivity to MG132 treatment. + + + + 16275144 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking + + + + 16407214 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression in bladder cancer cells was associated with up-regulation of ID-1 and cancer staging. + + + + 16525633 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor gene mutation is associated with adenocarcinomas of the lung + + + + 16503085 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Understanding of EGFR identity in colorectal cancer which could be useful in reconsidering the predictive tools for the identification of tumors putatively responsive to EGFR targeted therapy. + + + + 16524971 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression is not stable during metastatic progression in a significant proportion of non-small-cell-lung cancer patients. + + + + 16524970 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation. + + + + 16507511 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our work sheds light into the nature and regulation of the nuclear EGFR pathway and provides a plausible mechanism by which cells shuttle cell-surface EGFR and potentially other RTKs through the nuclear pore complex and into the nuclear compartment. + + + + 16552725 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Circular dichroism spectroscopy indicated that the EGFR C-terminal domain possessed a significant level of secondary structure in the form of alpha-helices and beta-sheets, with a marginal change in beta-sheet content occurring upon phosphorylation. + + + + 16597832 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways + + + + 16574793 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + RNa silencing had no inhibitory effect on cell proliferation, migration and activation status of EGFR-coupled signaling cascades in glioma cells. + + + + 16685454 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that decorin protein core inhibits tumor xenograft growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. + + + + 16835231 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Induction of keratinocyte migration is conveyed through EGFR, promoted by endogenous HB-EGF and requires GSK-3alpha activity. + + + + 16806170 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ITSN forms a complex with Cbl in vivo mediated by the Src homology (SH) 3 domains binding to the Pro-rich COOH terminus of Cbl. This interaction stimulates the ubiquitylation and degradation of the activated EGFR. + + + + 16914641 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR intron 1 polymorphism may influence response to treatment with tyrosine kinase inhibitors in breast cancer. + + + + 17102595 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Inhibition of EGFR activity decreases cell migration involved in insulin-induced wound repair. Insulin stimulates wound healing in corneal epithelium by activating EGFR. This points to novel insulin signaling pathway during corneal wound healing. + + + + 17149366 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + UBPY-mediated EGFR de-ubiquitination promotes EGFR degradation + + + + 17121848 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR on the cell surface of cancer cells must exist as an untethered dimer that adopts a previously unreported conformation that is inactive which may provide synergy between monoclonal antibodies and AG1478 in a xenograft model. + + + + 17092939 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR targeted strategies for pancreatic cancer + + + + 17228128 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene amplification is frequently present in prostatic phyllodes tumors in humans. + + + + 17192792 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells. + + + + 17234718 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms. + + + + 17214962 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our results show EGFR mutations did not occur in these patients suggesting that gefitinib is unlikely to be effective in patients with tumors not harboring specific EGFR TK domain. + + + + 17290443 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + There is a distinct clinical profile for NSCLC patients with the EGFR mutation + + + + 17409862 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Inhibition of the EGFR signaling pathway reduces ductal carcinoma in situ mammosphere-forming efficiency. + + + + 17440163 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways. + + + + 17493236 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results show a a significant correlation between the EGFR L858R mutation and the expression of p-Akt and suggest that the activation of Akt is dependent on EGFR mutation pattern. + + + + 17493174 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo + + + + 12435727 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The results suggest that activation and nuclear localization of EGFR may be needed for induction of NOS-2 in response to elevated intraocular pressure in glaucomatous optic neuropathy. + + + + 12828935 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + depending on their localization, oxytocin receptors transactivate EGFR and activate ERK1/2 using different signalling intermediates. The final outcome is a different temporal pattern of EGFR and ERK1/2 phosphorylation + + + + 12955084 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR was observed in only a small fraction of colorectal carcinomas, but were frequently accompanied by gene amplification. + + + + 15143334 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The tumor-specific mutation of epidermal growth factor receptor promotes cells survival and dimerization with the wild-type EGFR. + + + + 15221011 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. + + + + 12218189 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Endothelial cell vessel assembly requires EGFR signaling transduction pathways. + + + + 15166495 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. + + + + 15358139 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + trans-activation by calcium-sensing receptor + + + + 15219850 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + transactivation through CCR3 is a critical pathway that elicits mitogen-activated protein kinase activation and cytokine production in bronchial epithelial cells + + + + 15219825 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor interacts with gastrointestinal peptide hormone receptors to regulate mitogenic signaling and cell migration [review] + + + + 15621729 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + For genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between systemic lupus erythematosus and controls. In addition, there was significant association between the two groups in allelic frequency of the T allele. + + + + 15540509 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation for prognosis of breast cancer. + + + + 15665312 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In addition to EGFR mutations, other factors in non-small cell lung carcinoma cells, such as high expression of ErbB family members, may constitutively activate AKT and sensitize cells to EGFR inhibitors. + + + + 15665299 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + NHERF stabilizes EGFR at the cell surface and slows the rate of endocytosis without affecting recycling + + + + 15469991 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the epidermal growth factor receptor has a role in activating ERK with extracellular oxidation by taurine chloramine + + + + 15166244 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + a novel regulatory role for Galphas in EGF receptor degradation and provide mechanistic insights into the function of Galphas in endocytic sorting + + + + 15469987 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A common polymorphism in the EGFR promoter was associated with altered promoter activity and gene expression both in vitro and in vivo. + + + + 15665278 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + An EGFR mutant with four amino acid changes exhibited binding to the conformationally-specific monoclonal antibodies. and human epidermal growth factor + + + + 16355407 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Breast carcinomas with squamous differentiation are a distinct subgroup of breast tumors with a very high frequency of EGFR expression + + + + 16273187 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + LPA acts upstream of various receptor tyrosine kinases and COX-2, and thus may act as a potent stimulator of colorectal cancer. + + + + 16237757 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation. + + + + 16314000 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Activation of erbB1 leads to phosphorylation of protein phosphatase 2A, inhibiting its activity, which provides a rapid means of sensing the loss of epithelial integrity and subsequently restoring barrier function. + + + + 16293617 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells. + + + + 16445385 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR-induced signaling and Grb2 are essential for formation of clathrin-coated pits accommodating the EGFR, while activation of MAPK and PI3K is not required. + + + + 16382132 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation + + + + 16414009 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The existence of mutations in the tyrosine kinase domain of the EGFR gene in a small subset of synovial sarcomas suggests that only few patients may profit from the tyrosine kinase inhibitor therapy. + + + + 16514409 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Taken together, these data provide direct evidence for the role of EGFR ubiquitination in receptor targeting to the lysosome and implicate Lys63-linked polyubiquitin chains in this sorting process. + + + + 16543144 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in EGFR is associated with Non-Small-Cell Lung Carcinoma + + + + 16555991 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutation and gene amplification potentially have impact on the responsiveness to EGFR targeting agents in ovarian cancer. + + + + 16554736 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression + + + + 16565089 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The steric hindrance created by the antibody near the EGFR dimer interface interferes with receptor dimerization, and we postulate this as the structural origin for the antitumor effect of mAb 806. + + + + 16531225 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Significant higher expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor are associated with neuroendocrine tumors + + + + 16596194 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + overexpression of epidermal growth factor receptor due to missense mutation and single nucleotide polymorphisms is associated with gastrointestinal tract tumor + + + + 16596188 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The aim of this review is the biology of the EGFR and its use as a target for a new class of anticancer agents for colorectal cancer.Results available so far demonstrated a manageable and acceptable toxicity profile and a promising level of activity. + + + + 16637508 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + No change in expression levels of EGFR was seen in the histologic progression to esophageal adenocarcinoma. + + + + 16702519 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways + + + + 16702213 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF stimulates receptor neddylation, which enhances subsequent ubiquitylation, as well as sorting of EGFR for degradation + + + + 16735510 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR functions as control center & integration site for signaling processes, involving stimulation with EGF. It has 6 docking sites for Grb2 and is a direct binding partner of STAT5. + + + + 16729043 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Significantly elevated epidermal growth factor receptor is associated with metastatic malignant melanoma patients with an inverse correlation between EGF-R and IL-6 levels. + + + + 16845329 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The CDK/cyclin-like complex formed by two kinase domains thus explains the activation of EGFR-family receptors by homo- or heterodimerization. + + + + 16777603 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The -216T allele was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). + + + + 16885506 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that treatment of tumor cell lines with the epidermal growth factor receptor-specific inhibitor cetuximab results in paradox phosphorylation of tyrosine 1173 in the receptor. + + + + 16904111 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the impacts of smoking and sex on the risk of EGFRmut non-small-cell lung cancers (NSCLC) are different from those for EGFRwt NSCLC + + + + 17054433 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + N-linked glycan with GlcNAc termini linked to EGFR is the target to interact with ganglioside GM3, causing inhibition of EGF-induced EGFR tyrosine kinase + + + + 17142315 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in epidermal growth factor receptor is associated with lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas + + + + 17238183 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon. + + + + 17215517 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Aldosterone leads to enhanced EGFR expression via interaction with EGFR promoter, which is mineralocorticoid receptor specific and could contribute to the aldosterone-induced increase in fibronectin abundance. + + + + 17311890 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Alterations in PTEN and amplification of EGFR are uncommon in pediatric malignant gliomas, in contrast to adult malignant gliomas. + + + + 17328268 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Tenascin C repeat Ten14 in monomeric form does not bind EGFR with sufficient stability so as to induce degradation of receptor, or undergo EGFR-mediated internalization over either the short (20 min) or long (48 h) term + + + + 17311283 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + No siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma. + + + + 17310847 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The presence of EGFR mutations had no effect on survival. + + + + 17337084 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + examinination of distributions of three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers + + + + 17455987 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in the EGFR tyrosine kinase domain correlate with the clinical response to Gefitinib in lung cancer patients. + + + + 17455141 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our findings suggest that the balance between hepsin and its inhibitor, HAI-2, may have prognostic value in RCC. + + + + 17425591 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Role of lipid rafts in EGFR-mediated cancer cell chemotaxis. + + + + 17453416 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results suggest a potential mechanism by which maintenance of low levels of EGFR expression and subsequent EGFR upregulation may be attributed to the loss of transcriptional repression of EGFR gene expression in hormone-dependent breast cancer cells + + + + 11968000 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is an aldosterone-induced protein and is involved in the manifold (patho)biological actions of aldosterone + + + + 12939263 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses + + + + 14660604 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Rac activation upon cell-cell contact formation is dependent on signaling from here + + + + 12147707 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor is activated in a pathway that requires ARF4 to induce phospholipase D2 + + + + 12446727 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase + + + + 11912208 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + role in mediating thromboxane A2-dependent -signal-regulated kinase activation + + + + 12534349 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of an introduced EGFR, under an E1A-insensitive heterologous promoter, blocked E1A induction of apoptosis in SCC cells. E1A-mediated EGFR downregulation appears to be the cause not consequence of E1A-induced apoptosis in these cells. + + + + 12673202 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the EGF receptor is abundantly expressed in epithelioid vascular smooth muscle cells and the activation of this receptor results in cell cycle arrest through activation of the mitogen-activated protein kinase pathway + + + + 14551192 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A significantly higher frequency of EGFR expression occurred in PC than in AC glottic cancer. + + + + 14977086 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR is associated with recurrent non-small cell lung cancer + + + + 14734462 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Sustained hyaluronan depolymerization is expected to cause tissue kallikrein activation, EGF release, and EGFR signaling. + + + + 14988406 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + novel mechanism by which IGF-I induces ERK activation in a manner that is dependent on the basal level of EGFR-TK activity, but is independent of receptor transactivation. + + + + 15271882 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The overall time-dependent activation of EGFR autophosphorylation was identical in cells treated with 1 nm BTC or 1.5 nm EGF. + + + + 15192046 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PPARgamma and EGFR signalling have roles in urothelial terminal differentiation + + + + 15054105 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor is dephosphorylated at endomembranes after ligand-mediated endocytosis + + + + 15215236 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in non-small cell lung cancers. + + + + 15709185 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cpd 5-caused ERK phosphorylation is probably regulated by both EGFR-dependent and EGFR-independent pathways. + + + + 15672448 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that epidermal growth factor receptor signaling results in phosphorylation of CUG-BP1, and leads to increased binding of CUG-BP1 to CCAAT/enhancer binding protein beta (C/EBP beta) mRNA and elevated expression of the C/EBPbeta LIP isoform. + + + + 15082764 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PTEN protein could inhibit cell invasion even in the presence of the constitutively active epidermal growth factor receptor(EGFR) + + + + 15986432 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + spatially distributed Monte Carlo based simulation framework to enable the simulation of in vivo receptor diffusion and dimerization + + + + 16318625 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Theaflavin-3, 3'-digallate may exert chemopreventive effects through the downregulation of the EGFR. + + + + 16353237 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of putative YXX Phi and dileucine (LL) transport motifs within Ad2 10.4-14.5 for down-regulation of Fas, TRAIL-R1, TRAIL-R2, and EGFR. + + + + 14506242 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + misfolding of the LDLR epidermal growth factor-AB pair results from low density lipoprotein receptor familial hypercholesterolemia mutations + + + + 15100232 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR antisense-odn can significantly inhibit proliferation of human hepatoma cells, indicating that EGFR may play important role in development of hepatoma and will be new target for its treatment. + + + + 16109531 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + RhoB is essential in regulating keratinocyte cell survival after UVB exposure through epidermal growth factor receptor signaling + + + + 16278215 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CsA affects EGF-r metabolism in gingival keratinocytes resulting in an increased number of cell surface receptors + + + + 11831486 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ligand-independent activation of the epidermal growth factor receptor is triggered by cholesterol depletion from the plasma membrane + + + + 12397069 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + this study, 11 analogs of a fragment of the B-loop of EGF-related peptides from several species were synthesized to study binding to A431 human epidermoid carcinoma using both 125I-EGF and [3'4'-3H-Tyr(22,29), Abu(20,31)]EGF(20-31)-NH(2). + + + + 11814623 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results demonstrate that 1,25(OH)(2)D(3) alters EGFR membrane trafficking and down-regulates EGFR growth signaling. + + + + 12181310 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Stimulation of cells with EGF rapidly leads to phosphorylation of Hrs, raising the question whether the EGF receptor tyrosine kinase phosphorylates Hrs directly. Several downstream kinases, rather than the active receptor kinase are responsible. + + + + 12180964 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ZO-1 bound to EGFR irrespective of the phosphorylation status of EGFR. EGFR associated ZO-1 was highly tyrosine-phosphorylated only in primary colorectal cancers but was dephosphorylated in the liver-metastasized cancers. + + + + 12708492 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFRvIII expressed in human tumors is phosphorylated and hence activated; sustained activation of EGFRvIII is implicated in the pathogenesis of non-small cell lung cancers + + + + 12708474 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + in glioblastoma multiforme patients a complex relationship exists between epidermal growth factor receptor expression and age + + + + 12582944 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor + + + + 14670955 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The epidermal growth factor receptor (EGFR) is one of signalling pathways activated during premalignant proliferative changes in the airway epithelium. + + + + 15253134 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides + + + + 11796728 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The results of this study indicate that dual inhibition of focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) signaling pathways can cooperatively enhance apoptosis in breast cancers. + + + + 12167618 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene expression is identified in recurrent glioblastoma multiforme + + + + 12754350 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR has a role in beta2 tyrosine phosphorylation of AP-2 by interacting at receptor 974YRAL and di-leucine motifs + + + + 12900408 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors + + + + 11894095 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that by using RNA interference , the expression of endogenous erbB1 can be specifically and extensively suppressed in A431 human epidermoid carcinoma cells. + + + + 12681285 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Five autophosphorylation sites in the extra-kinase C-terminal domain of EGFR are not required for the ability of EGFR to induce morphological differentiation of PC12 cells. + + + + 12615082 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In patients with breast cancer, most CNS metastatic tumor deposits showed expression for either EGFR or HER-2/neu, and less often for both. + + + + 15335267 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis. + + + + 12603863 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results suggest that epidermal growth factor receptor and protein kinase C activation are involved in 12- O-tetradecanoylphorbol-13-acetate-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells. + + + + 12733059 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Nitric oxide and nitric oxide donors induce EGF receptor phosphorylations, in A431 tumor cells. + + + + 12694196 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Dephosphorylation of the EGFR and the consequent suppression of EGFR signalling. Review. + + + + 12018405 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + propose a role of Ent-1 in the trafficking of EGFR to down-regulate intestinal mitogenic signals, highlighting the mechanisms of cell growth arrest associated with enterocytic differentiation + + + + 12657642 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation + + + + 15556944 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma). + + + + 15522239 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + HB-EGF/HER-1 signaling is relevant to mesenchymal stem cell biology, by regulating both proliferation and differentiation + + + + 15755902 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Findings suggest that a distinct minority of colorectal adenocarcinomas exhibit somatic mutations of EGFR, and these tumors may be susceptible to gefitinib treatment. + + + + 15746034 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signaling has a role in regulating host defense and immune response by tightly controlling TLR2 induction during bacterial infections + + + + 16115866 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Active mutation of the EGFR kinase domain was strongly associated with response to gefitinib + + + + 15956035 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The effects of high glucose on proximal tubular cells proliferation, reduced apoptosis and increased NHE3 mRNA levels are mediated by EGFR-dependent up-regulation of SGK-1. + + + + 16105029 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Two tyrosine residues in the C terminus of human TRPC4 phosphorylated following epidermal growth factor (EGF) receptor stimulation of COS-7 cells. + + + + 16144838 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) can induce the clustering of epidermal growth factor receptor (EGFR) in human amnion FL cells. + + + + 16488447 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells. + + + + 16545487 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The Increased expression of erbB-1 was associated with increased levels of Ki-67 and MCM2 expression, and combined overexpression of these receptors was associated with the highest levels of proliferation, suggesting a synergistic effect. + + + + 16609045 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The Epidermal Growth Factor Receptor represent independents prognostic marker for intracranial ependymomas to identify patient subgroups with different risk profiles in further clinical investigations. + + + + 16609018 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + 96% of tumor samples were positive for EGFR expression; 63% were positive for activated EGFR; 76% were positive for activated Akt; and 96% were positive for activated ERK1/2. + + + + 16629834 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the versican G3 domain regulates neuronal attachment, neurite outgrowth, and synaptic function of hippocampal neurons via EGFR-dependent and -independent signaling pathways + + + + 16648628 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor and plays a crucial role for regulating the amount of the EGF receptor on the cell surface membrane + + + + 16803894 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells. + + + + 16847054 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors + + + + 16820093 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + receptor stability is regulated by MUC1 expression + + + + 16983337 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + somatic mutations in EGFR quantitatively differ in pharmacology and signaling properties + + + + 16968809 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The findings of EGFR abnormalities in lung cancer have supported the notion that different molecular mechanisms and pathways are involved in the pathogenesis of lung cancer arising in never and ever smokers. + + + + 16979526 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In midgut carcinoid tumor stroma PDGFRalpha was expressed in 35%, PDGFRbeta in 94% and EGFR in 9%. + + + + 17047316 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations and amplification/overdose in the EGFR gene are present in low-grade oligodendroglial tumours, and may contribute to the development of these brain neoplasms. + + + + 17143531 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Since the EGF receptor is often overexpressed in skin cancers, it might be possible to significantly reduce the proliferative potential of these cells making them good targets for laser-pulsed UV light treatment. + + + + 17143527 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The expression of EGFR in postmitotic, terminally differentiated adult retinal neurons suggests that EGFR has pleiotropic functions. + + + + 17111374 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations. + + + + 17142003 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + An inflammation-dependent EGF-R cascade causes overproduction of the gel-forming mucin MUC5AC, which accumulates in cholesterol gallstone disease. The ability to interrupt this cascade is of potential interest in the prevention of cholesterol gallstones. + + + + 17148666 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Detailed pharmacokinetic characterization of this bioprobe could assist in the development of a kinetic model that would afford accurate measurement of EGFR content in tumors. + + + + 17210462 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + W-13 calmodulin inhibitor has a role in epidermal growth factor receptor activation + + + + 17227773 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + long term treatment with epidermal growth factor (EGF) leads to a marked increase in the levels of ADAM17, which also increases the shedding of several substrates of ADAM17, including the desmosomal cadherin Dsg-2 + + + + 17227756 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + protein-tyrosine phosphatase 1B governs differential recruitment of signaling pathways involved in EGFR regulation of epithelial ion transport. + + + + 17339316 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + incidence of somatic mutations in the tyrosine kinase domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival of pancreatic adenocarcinoma patients + + + + 17354229 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is hypermethylated and silenced in a subset of solid tumor cell lines and primary tumor specimens, and cotreatment with decitabine and gefitinib has an additive effect only in EGFR methylated breast cancer cell lines. + + + + 17369752 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Targeting EGFR is a novel strategy against neuroblastoma. + + + + 17482563 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + present results suggest that it is not a useful indicator of prognosis in oral squamous cell carcinoma + + + + 17448210 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Study has identified a subset of naturally occurring EGFR mutations that lack a critical radioprotective function of EGFR, providing valuable insights on how the EGFR mediates cell survival in response to radiation in NSCLC cell lines. + + + + 17545606 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer + + + + 17510392 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + among adenocarcinomas, nonmucinous and mucinous bronchioloalveolar carcinoma components were significantly associated with EGFR and K-ras gene mutations, respectively + + + + 17580276 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + cholesterol depletion with cyclodextrin induced an increase in both basal and EGF-stimulated EGF receptor phosphorylation, at specific tyrosine sites, that was associated with an increase in the intrinsic kinase activity of the EGF receptor kinase. + + + + 14530278 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. + + + + 12953099 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Statistically significant relation existed between the ovarian cancer metastatic potential and EGFR expression level. + + + + 15185528 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors + + + + 12127695 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains + + + + 12297050 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. + + + + 12297049 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data support that EGFR and HER-2/neu play an important role in cell cycle control in ductal carcinoma in situ. + + + + 12825853 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + contig map for the EGFR region and markers positioned on its associated physical map to the analysis of 7p11.2 amplifications in a series of glioblastomas. + + + + 11916499 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Expression of EGF and EGFR is involved in the gallbladder carcinogenesis, and is related to high activity of cell proliferation. + + + + 12654182 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. + + + + 12814937 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + whole gene amplifications of egfr are rare in invasive breast cancer and explain protein overexpression in only about 12.5% of invasive breast cancer cases + + + + 15031710 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data demonstrate that at least four different sets of endogenously expressed gangliosides, including GD3, did not have a significant effect on epidermal growth factor receptor distribution in the plasma membrane. + + + + 15182358 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + cholangiocarcinoma cells exhibit sustained EGFR activation due to defective receptor internalization + + + + 15519654 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR microsatellite polymorphism is associated with autosomal dominant polycystic kidney disease. + + + + 12653106 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + results support a structural model for oligomerization of EGF receptors in which dimers are positioned head-to-head with respect to the ligand-binding site + + + + 14690686 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + c-erbB-2 and EGF-R are overexpressed in breast neoplasms and have an inverse association with Estrogen Receptor expression + + + + 15233293 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers. + + + + 15741570 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of EGFR mutations in malignant pleural effusion of non-small cell lung cancer (case report) + + + + 15913841 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This study suggests that coexpression of LN-5 gamma2 and EGFR is closely related to the progression and poor prognosis of esophageal SCC. + + + + 16103736 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in non-small cell lung cancer + + + + 16322287 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data suggest that the EGFR immunopositivity can be considered as reliable predictors of disease stage in urine ThinPrep (TP) specimens. + + + + 16303044 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor. + + + + 16443754 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9. + + + + 16543231 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that c-erbB-1 and c-erbB-2 are differentially regulated in cancers of the papilla of Vater and pancreas, suggesting that the two types of cancer are biologically different. + + + + 16489645 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + COX-2 and EGFR may be cooperative in the stepwise progression from Barrett's esophagus to adenocarcinoma, thereby leading to carcinogenesis. + + + + 16521222 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data provide the first evidence of somatic mutations of the EGFR gene in bile duct carcinoma. + + + + 16551849 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the trophic properties of gastrin in colorectal cancer may be mediated in part by transactivation of the EGFR and phosphorylation of ERK1/2, leading to degradation of PPARgamma protein and a decrease in PPARgamma activation + + + + 16574647 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Salient features of the structural model for EGFR regulation and argue that the intramolecular tether provides only limited autoinhibitory control of EGFR activity. + + + + 16571657 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + role for p38 MAP kinase in the regulation of EGFR endocytosis + + + + 16683917 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + patients with mutant-type EGFR might be treated with EGFR-TKIs before any other drugs + + + + 16646071 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway. + + + + 16786197 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of activating mutations within EGFR in both esophageal and pancreatic adenocarcinomas and a model of the role of EGFR signaling in neoplasms + + + + 16857803 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the disulfide-bonded structure of the membrane-proximal portion of the EGF receptor, rather than its primary sequence, is important for EGF binding and signaling but is not involved in localizing the receptor to lipid rafts + + + + 16842869 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) + + + + 16970944 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The EGFR protein was carried out in 71 of these cases, nonproliferative benign breast disease, proliferative BBD without atypia, proliferative BBD with atypia, carcinoma in situ (n=15) or invasive carcinoma. + + + + 17164758 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins + + + + 17177839 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + This study is the first to demonstrate that EGFR is implicated in IFNgamma-dependent signaling pathways. + + + + 17362940 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of specimens from patients with cancer of unknown primary for EGFR gene mutation, gene amplification, transcriptional regulation as well as protein expression + + + + 17390112 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Analysis of tumor EGFR mutations in patients with NSCLC could be used to identify patients suitable for treatment with gefitinib to obtain optimum response and disease control rates. + + + + 17368623 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Findings suggest that the EGFR mutation is frequent in Korean lung cancer patients. + + + + 17321325 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3 + + + + 17616668 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas + + + + 17549377 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of EGFR and HER-2 is associated with pancreatic ductal adenocarcinoma + + + + 17549361 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + sequestration in non-caveolar lipid rafts inhibits lipid binding + + + + 11886870 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 & ERCC1 in DU145 & LNCaP prostate carcinoma through MAPK signaling indicating a capacity of the EGFR-ERK signaling to modulate DNA repair in cancer cells. + + + + 12643788 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + TPA-induced AP-1 activation requires EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation. + + + + 12527890 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PGE2 regulates cell migration via the EGFR, and affects cell division and neoplasm invasiveneess. + + + + 12824187 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + heregulin/EGFR system as a possible important physiologic growth regulatory system in melanocytes in which multiple deregulations may occur during progression toward melanoma, all resulting in, or indicating, growth factor independence. + + + + 14632199 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and COX-2 cooperate to promote cervical neoplasm progression + + + + 14977838 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. + + + + 12607604 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The Id-1-induced androgen-independent prostate cancer cell growth was correlated with up-regulation of EGF-R. + + + + 14688027 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + CaM co-immunoprecipitates with EGF-activated and non-activated receptors + + + + 14960328 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell surface expression of EGFR is associated with osteosarcoma pathogenesis + + + + 15026342 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In each of these gliomas, the founding molecule was generated by a simple event that circularizes a chromosome fragment overlapping the epidermal growth factor receptor gene. + + + + 15269346 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck + + + + 15254682 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that EGFR amplification is a relatively rare event in larynx carcinogenesis that obviously does not predispose to tumor progression. + + + + 15592685 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression + + + + 15791567 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation + + + + 15897877 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + second cysteine-rich region contains targeting information for caveolae/rafts + + + + 12023273 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that blockade of epidermal growth factor receptor import into the nucleus also blocks radiation-induced activation of DNA-PK, inhibits DNA repair, and increases radiosensitivity of treated cells. + + + + 16000298 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization. + + + + 16263120 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR expression and signaling does not seeme to be affected by treatment with erlotinib or gefitinib + + + + 16278407 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is often strongly expressed and is a potential therapeutic target in patients with malignant thymic tumors + + + + 11935304 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma. + + + + 12419588 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results provide an explanation for cell surface receptor cross-talk involving the Met receptor and link G protein-coupled receptors and the epidermal growth factor receptor to the oncogenic potential of Met signaling in human carcinoma cells. + + + + 15123705 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR, PYK2, Yes, and SHP-2 are involved in transduction of the TF/FVIIa signal possibly via transactivation of the EGF receptor. + + + + 15213840 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The study found that over-expression of EGFR occurred more often in cases of cervical cancer (50%) compared to breast cancer cases (36%), while in breast cancer EGFR expression correlated significantly with metastasis of the lymph nodes. + + + + 12683217 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ERBB1 is overexpressed and may play a role in high-grade diffusely infiltrative pediatric brain stem glioma + + + + 14506149 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor. + + + + 12871937 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + an interrelationship is now known to exist between the IGF and EGF receptors [review] + + + + 15253384 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. + + + + 11992543 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the mechanism of attenuated ERK signaling in EGFR-overexpressing cells is a sequestration of ERKs at the cell membrane in EGFR-containing complexes. + + + + 12556561 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor may have a role in disease relapse and progression to androgen-independence in human prostate cancer + + + + 12429632 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + P. 445:"The EGF receptor (EGFR), a glycoprotein of 170 kDA, has also been intensily studied and finally located on chromosome 17, region p13l13-q22." + + + + 15134305 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signaling involves reinforcing altered gene expression of uPAR,thus further inducing cell motility. + + + + 15302576 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Detection of serum epidermal growth factor receptor in the diagnosis of proliferation of pituitary adenomas + + + + 12133497 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that detachment-induced expression of Bim requires a lack of beta(1)-integrin engagement, downregulation of EGF receptor (EGFR) expression and inhibition of Erk signalling. + + + + 12844146 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + signaling intensity determines intracellular protein interactions, ubiquitination, and internalization + + + + 12734385 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + PGF(2 alpha)-FP receptor may promote endometrial tumorigenesis via phospholipase C-mediated phosphorylation of EGF receptor and MAPK signaling pathways. + + + + 14764825 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + therapeutic potential of siRNA to impact DeltaEGFR as a glioma-specific target + + + + 15580296 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + protein kinase B/Akt phosphorylation is stimulated by mechanical stretch in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor + + + + 15545271 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Review. Mucin transcription in response to both gram-positive bacteria and tobacco smoke is mediated through activation of the epidermal growth factor receptor (EGFR). + + + + 12568494 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + findings establish Cbl protein as the major endogenous ubiquitin ligase responsible for epidermal growth factor receptor degradation + + + + 12754251 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR binds to c-src and has a role in oncogenesis + + + + 12604776 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway. + + + + 15300588 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Grb2-mediated recruitment of the functional RING domain of Cbl to the EGFR is essential and sufficient to support receptor endocytosis + + + + 15635092 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + decreased EGF receptor tyrosine phosphorylation and aberrant recruitment of the adaptor proteins ShcA and Grb2 to the EGF receptor in cells harbouring the hepatitis C virus subgenomic replicon + + + + 15784896 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + epidermal growth factor receptor is activated by imatinib mesylate, resulting in cyclooxygenase-2 induction and prostaglandin E2 accumulation + + + + 15844661 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of ligand-induced dimer-tetramer transition during the epidermal growth factor receptor activation of the cell surface + + + + 15994331 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF + + + + 12099696 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes. + + + + 14681060 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and ErbB-2 have roles in ligand-dependent apoptosis that could be a natural mechanism to protect tissues from unrestricted proliferation + + + + 14711810 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Carbon black causes oxidative stress-mediated proliferation of airway epithelium, involving activation of EGF-R. + + + + 15298855 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + An inhibitor of this and of the mTOR pathwway inhibits growth of glioma in a xenograft mousse model. + + + + 15657358 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of activating mutations in catalytic domain of EGFR in 3.5% (2 of 57) of ovarian cancers + + + + 16061871 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The mechanism of deoxycholic acid-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of amphiregulin release from the basolateral cell membrane. + + + + 16213893 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The patients with mutations of EGFR to have a more favorable prognosis than those with wild type (p=0.033). + + + + 16198442 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Acquisition of resistance to tyrosine kinase inhibitors in non-small cell lung cancer is linked to a specific secondary somatic mutation, EGFR T790M. + + + + 16258541 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Reactive Oxygen Species-induced Goblet Cell metaplasia in normal human bronchial epithelial cells is associated with Hyaluronan depolymerization and Epidermal Growth Factor (EGF) processing by Tissue Kallikrein followed by EGF Receptor signaling. + + + + 16424381 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Data show that long-term ciliated cell hyperplasia and activation of epidermal growth factor receptor signaling coincide with mucous cell metaplasia after respiratory viral clearance in airways. + + + + 16453019 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + study provides a new insight into oncogenic signaling by EGFRvIII and improves our understanding of how autocrine loops are generated in glioma + + + + 16424019 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. + + + + 16478662 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Epidermal growth factor receptor and KRAS mutation patterns is associated with non-small cell lung cancer patients + + + + 16533793 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor trafficking and signaling occur through a subset of signaling molecules including p44/42 MAPK and Gab1. + + + + 16715136 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFRvIII expression may regulate phenotypic plasticity in ovarian cancer and thereby contribute to more aggressive disease + + + + 16788982 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of the mechanisms of action of EGFR-TK-inhibition in hepatocellular cancer cells by erlotinib + + + + 16937526 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The phosphorylation sites that are most strongly correlated with migration & proliferation were identified, eg. EGFR Y1173 correlates with proliferation. + + + + 17016520 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + In this article, we review efforts that have been undertaken to identify genomic determinants of drug susceptibility to EGFR tyrosine kinase inhibitors, with particular focus on the role of gene mutations. + + + + 17052295 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Combined blockade of both epidermal growth factor receptors and G protein coupled recaptors (GPCRs) may be a strategy to treat cancers, including head and neck squamous cell carcinoma that shows cross-talk between GPCR and EGFR signaling pathways. + + + + 17178880 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, reactive oxygen species production, and excessive collagen synthesis + + + + 17339338 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + REVIEW: The expression of EGFR in glioimas and its potential as a drug target in these tumors are discussed. + + + + 17373877 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14. + + + + 17475671 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results demonstrate that ErbB1 signaling is hyperactive in squamous cell carcinoma cells, but not basal cell carcinoma cells. + + + + 17525275 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGCG inhibits the binding of EGF to the EGFR and the subsequent dimerization and activation of the EGFR by altering membrane organization + + + + 17616711 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + endothelin A receptor and epidermal growth factor receptor are targeted by the combination of ZD4054 and gefitinib in ovarian carcinoma + + + + 17616694 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is a necessary component for HCMV-triggered signalling and viral entry + + + + 12879076 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Results demonstrate that mice humanised for epidermal growth factor receptor (EGFR) display tissue-specific hypomorphic phenotypes and describe a novel function for EGFR in bone development. + + + + 12925580 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + deltaEGFR may contribute to glioblastoma development + + + + 12704666 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + demonstration that metalloproteinase-mediated transactivation of the EGFR is a key mechanism of the cellular signalling network that promotes MAPK activation as well as tumour cell migration and invasion + + + + 14647423 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + somatic mutations of EGFR were found in 15 of 58 non-small cell lung cancer tumors from Japan and 1 of 61 from the United States; EGFR mutations may predict sensitivity to gefitinib + + + + 15118125 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib. + + + + 15118073 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Levels of this receptor are lowered in cryptorchism. + + + + 12508124 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + mutant EGFRs selectively transduce survival signals on which nonsmall cell lung cancers become dependent + + + + 15284455 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Upregulation of leucine-rich repeats and immunoglobulin-like domains 1 is followed by enhanced ubiquitylation and degradation of EGFR + + + + 15282549 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells + + + + 15542601 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Our results suggest a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function. + + + + 15541730 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + analysis of conformations of the epidermal growth factor receptor and antibody binding [review] + + + + 15494003 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR is increased by cAMP, a potent inducer of decidualization of the endometrial stroma. + + + + 15562026 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Endocytosis is regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. + + + + 12399475 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2 + + + + 14963038 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells, resulting in increased cell-cell adhesion + + + + 15205458 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation + + + + 15797859 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + the EGF receptor plays a central role in the signaling pathway that links albumin to the activation of ERK1/ERK2 and increased expression of IL-8 + + + + 15829704 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The membrane-anchoring domain of EGFR ligands dictates their ability to operate in juxtacrine mode. + + + + 15829568 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery + + + + 15967033 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + rab7 regulates the endocytic trafficking of the EGF.EGFR complex by regulating its lysosomal degradation + + + + 16282324 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes + + + + 16263724 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Gefitinib-sensitizing mutations in the EGFR gene were found in human esophageal tumors. + + + + 16707764 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + High epidermal growth factor receptor is associated with disease recurrence in colon cancer patients + + + + 16614884 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ERBB-1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma. + + + + 16815198 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation + + + + 16849327 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined. + + + + 17023689 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR and TrkB crosstalk each other in response to EGF and BDNF, leading to cell survival pathway activation in ovarian cancer cells. + + + + 16964397 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + IL-13 and EGFR pathways make critical but quite distinct contributions to gene regulation in airway epithelial cells, and that both pathways affect expression of the key transcription factor, FOXA2, a known regulator of mucus production. + + + + 16980555 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)[p145met] + + + + 17062641 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Even a modest attenuation of EGF-R signaling leads to a severe defect in postnatal growth of the beta-cells, which leads to the development of diabetes in transgenic mice. + + + + 17130473 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Review. Excessive EGFR signalling plays a critical role in NSCLC tumorigenesis in patients harbouring an EGFR mutation. Mutant EGFRs drive the growth of cancer cells & maintain their malignant phenotype by selective activation of Akt & STAT pathways. + + + + 17158592 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + S100beta-v-erbB transgenic rats may serve as a useful animal model for the identification of EGFR-related molecular targets and as a tool for the assessment of novel therapeutic approaches. + + + + 17146284 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFRvIII mutation in lung cancer is correlated with increased expression of EGFR + + + + 17203167 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR gene mutation does not change the effect of gefitinib in non-small cell lung cancer cells + + + + 17203166 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Overexpression of epidermal growth factor receptor is associated with esophageal and esophagogastric junction adenocarcinomas + + + + 17211865 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Estradiol receptor alpha and androgen receptor upregulate EGFR phosphorylation. + + + + 17261767 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + overexpression of spartin results in a prominent decrease in EGFR degradation + + + + 17332501 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation. + + + + 17307140 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Targeting of EGFR to determine molecular alterations of this gene may be useful in the management of patients with brain metastases. + + + + 17284372 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR cannot compensate for IGF1R depletion. + + + + 17320820 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR signaling is controlled by a novel mechanism involving trafficking-dependent alterations in receptor compartmentalization. + + + + 17320394 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + decorin is taken up by more than one endocytic pathway; uptake depends on EGFR signaling rather than trafficking along the same pathway + + + + 17335953 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR pathway, EGFR mutation and/or amplification, may be involved in lung carcinogenesis. + + + + 17487398 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement + + + + 17431415 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK pathways. + + + + 17469127 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + MIP-3alpha-mediated ERK1/2 activation in Caco-2 cells appeared to require metalloproteinase-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR. + + + + 17548638 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC. + + + + 17548604 + + + + + + + + 2007 + 8 + 25 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + different EGF receptor mutations exert various negative mechanisms that have the potential to modify receptor internalization and may involve resistance to tyrosine kinase inhibitors in cancers [EGFRvIII, EGF Receptor VIII] + + + + 16969069 + + + + + + + + 2007 + 5 + 5 + 10 + 2 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + S1P transactivates c-Met and EGFR in gastric cancer cells. + + + + 15556605 + + + + + + + + 2005 + 1 + 15 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR-related protein (ERRP) is a 53 to 55 kDa protein that is a natural inhibitor of EGFRs in human but not in mouse or rat cells. + + + + 15767552 + + + + + + + + 2005 + 7 + 2 + 10 + 1 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + identification of ligand-induced site-specific phosphorylation of epidermal growth factor receptor + + + + 12954170 + + + + + + + + 2003 + 10 + 31 + 0 + 0 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation; cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK. + + + + 12135609 + + + + + + + + 2002 + 9 + 3 + 0 + 0 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + SKMG-3 cells produced high levels of EGFR protein. Signals from overexpressed EGFRs contribute to the constitutive phosphorylation of Erk, but these signals may not be required for the constitutive activation of PI3K or AKT1. + + + + 12532415 + + + + + + + + 2003 + 4 + 4 + 0 + 0 + 0 + + + + + + + + + 2010 + 1 + 21 + 0 + 0 + 0 + + + + + + + 18 + EGFR has been detected in the nucleus and might function as a transcription factor to activate gene transcription. + + + + 11533659 + + + + + + + + 2002 + 9 + 17 + 15 + 58 + 0 + + + + + + + + + 2002 + 9 + 18 + 14 + 59 + 0 + + + + + + + 18 + A truncated form of the hEGFR ectodomain comprising residues 1-501, unlike the full-length hEGFR ectodomain (residues 1-621), binds hEGF and hTGF-alpha with high affinity and is a competitive inhibitor of EGF-stimulated mitogenesis. + + + + 11467954 + + + + + + + + 2001 + 10 + 8 + 7 + 57 + 0 + + + + + + + + + 2001 + 10 + 10 + 14 + 59 + 0 + + + + + + + 18 + Chemical/biological model for EGFR activation. + + + + 11531336 + + + + + + + + 2001 + 9 + 22 + 11 + 35 + 0 + + + + + + + + + 2001 + 10 + 3 + 14 + 59 + 0 + + + + + + + 18 + HIV-1 protein interactions + + + 18 + Expression of HIV-1 Gag decreases the rate of EGFR downregulation by ESCRT proteins at endosomal membranes, an effect that is dependent on the presence of the TSG101 binding motif (PTAP) within the Gag C-terminal p6 domain + + + + 18187620 + + + + + 15507625 + + + + + + 8 + + + + + GeneID + + + 155030 + + + + + gag + + + + + Protein + + + 9629360 + + + + + Pr55(Gag) + + + + + 8 + + + + + Protein + + + 29725609 + + + + + epidermal growth factor receptor isoform a precursor + + + + + + + + + 2012 + 11 + 30 + 13 + 44 + 0 + + + + + + + + + 2016 + 7 + 28 + 14 + 32 + 0 + + + + + + + + + 18 + Interactions + + + 18 + Affinity Capture-Western; Two-hybrid + + + + 27956147 + + + + + + + + BioGRID + + + 108276 + + + + + BioGRID + + + + + 255 + + + + + BioGRID + + + 108276 + + + + + + + + + 255 + + + + + GeneID + + + 22866 + + + + + CNKSR2 + + + + + BioGRID + + + 116534 + + + + + + + + + + + + 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This interaction was modelled on a demonstrated interaction between EGFR from human and EGF from mouse. + + + + 8413296 + + + + + + + + BIND + + + 58085 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 1950 + + + + + EGF + + + + + Protein + + + 4503491 + + + + + NP_001954.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 25 + 0 + + + + + + + 18 + Tyrosine phophorylated EGFR interacts with STAT3. + + + + 12873986 + + + + + + + + BIND + + + 58094 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 6774 + + + + + STAT3 + + + + + Protein + + + 21618340 + + + + + NP_644805.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 24 + 0 + + + + + + + 18 + EGFR interacts with E-cadherin + + + + 14681060 + + + + + + + + BIND + + + 57962 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 999 + + + + + CDH1 + + + + + Protein + + + 4757960 + + + + + NP_004351.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 24 + 0 + + + + + + + 18 + ShcA interacts with EGFR. + + + + 8610109 + + + + + + + + BIND + + + 57973 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 6464 + + + + + SHC1 + + + + + Protein + + + 32261324 + + + + + NP_003020.2 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 24 + 0 + + + + + + + 18 + Grb10 interacts with EGFR. + + + + 9506989 + + + + + + + + BIND + + + 183784 + + + + + BIND + + + + + 8 + + + + + GeneID + + + 2887 + + + + + GRB10 + + + + + Protein + + + 48762695 + + + + + NP_001001550.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 22 + 0 + + + + + + + 18 + EGFR interacts with ErbB2. + + + + 15652750 + + + + + + + + BIND + + + 197186 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 255 + + + + + GeneID + + + 2064 + + + + + ERBB2 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 21 + 0 + + + + + + + 18 + EGF-R interacts with Shc. This interaction was modelled on a demonstrated interaction between human EGF-R and mouse Shc. + + + + 8887653 + + + + + + + + BIND + + + 180620 + + + + + BIND + + + + + 8 + + + + + GeneID + + + 6464 + + + + + SHC1 + + + + + Protein + + + 32261324 + + + + + NP_003020.2 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 15 + 0 + + + + + + + 18 + c-Cbl ubiquitinates an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between c-Cbl and EGFR, both from an unspecified species. + + + + 12234920 + + + + + + + + BIND + + + 262181 + + + + + BIND + + + + + 8 + + + + + GeneID + + + 867 + + + + + CBL + + + + + Protein + + + 52426745 + + + + + NP_005179.2 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 11 + 0 + + + + + + + 18 + EGFR interacts with 14-3-3-zeta. + + + + 15225635 + + + + + + + + BIND + + + 185503 + + + + + BIND + + + + + 8 + + + + + GeneID + + + 7534 + + + + + YWHAZ + + + + + Protein + + + 21735625 + + + + + NP_663723.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 5 + 0 + + + + + + + 18 + GRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR. + + + + 15782189 + + + + + + + + BIND + + + 215881 + + + + + BIND + + + + + 8 + + + + + GeneID + + + 2885 + + + + + GRB2 + + + + + Protein + + + 4504111 + + + + + NP_002077.1 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 16 + 3 + 0 + + + + + + + 18 + EGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human EGFR and bovine PLC-gamma. + + + + 2176151 + + + + + 2173144 + + + + + + + + BIND + + + 64773 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 5335 + + + + + PLCG1 + + + + + Protein + + + 33598948 + + + + + NP_002651.2 + + + + + + + + + 2005 + 5 + 16 + 15 + 49 + 0 + + + + + + + + + 2005 + 5 + 16 + 15 + 56 + 0 + + + + + + + 18 + CD44 interacts with EGFR. + + + + 12093135 + + + + + + + + BIND + + + 130543 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 960 + + + + + CD44 + + + + + Protein + + + 21361193 + + + + + NP_000601.2 + + + + + + + + + 2005 + 1 + 21 + 20 + 10 + 0 + + + + + + + + + 2005 + 1 + 21 + 20 + 19 + 0 + + + + + + + 18 + EGFR interacts with p85. This interaction was modeled on a demonstrated interaction between human EGFR and bovine p85. + + + + 1372092 + + + + + + + + BIND + + + 130445 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 5295 + + + + + PIK3R1 + + + + + Protein + + + 32455248 + + + + + NP_852664.1 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 39 + 0 + + + + + + + 18 + EGFR interacts with GRB2. + + + + 8305738 + + + + + + + + BIND + + + 128216 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 2885 + + + + + GRB2 + + + + + Protein + + + 4504111 + + + + + NP_002077.1 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 38 + 0 + + + + + + + 18 + Tyrosine phosphorlyated EGFR interacts with p85-beta. + + + + 11172806 + + + + + + + + BIND + + + 126459 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 5296 + + + + + PIK3R2 + + + + + Protein + + + 4826908 + + + + + NP_005018.1 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 36 + 0 + + + + + + + 18 + EGFR interacts with PLD1. This interaction was modelled on a demonstrated interaction between human EGFR and mouse PLD2. + + + + 9837959 + + + + + + + + BIND + + + 126457 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 5338 + + + + + PLD2 + + + + + Protein + + + 20070141 + + + + + NP_002654.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 36 + 0 + + + + + + + 18 + MUC1 interacts with and is tyrosine-phosphorylated by EGFR. + + + + 11483589 + + + + + + + + BIND + + + 134117 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 4582 + + + + + MUC1 + + + + + Protein + + + 33300665 + + + + + NP_877418.1 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 36 + 0 + + + + + + + 18 + Shc interacts with activated EGFR. + + + + 1623525 + + + + + + + + BIND + + + 126351 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 6464 + + + + + SHC1 + + + + + Protein + + + 32261324 + + + + + NP_003020.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 35 + 0 + + + + + + + 18 + EGFR interacts with the Grb2-RN-tre complex. + + + + 12399475 + + + + + + + + BIND + + + 123348 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 35 + 0 + + + + + + + 18 + Tyrosine phosphorylated EGFR interacts with and phosphorylates Vav2. + + + + 12454019 + + + + + + + + BIND + + + 123305 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 7410 + + + + + VAV2 + + + + + Protein + + + 40549448 + + + + + NP_003362.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 35 + 0 + + + + + + + 18 + Tyrosine-phosphorylated EGFR interacts with PAK1. + + + + 12522133 + + + + + + + + BIND + + + 123304 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 5058 + + + + + PAK1 + + + + + Protein + + + 42794769 + + + + + NP_002567.3 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 35 + 0 + + + + + + + 18 + EGFR interacts with EGFR. + + + + 15284455 + + + + + + + + BIND + + + 150971 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 1956 + + + + + EGFR + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 35 + 0 + + + + + + + 18 + EGFR interacts with Hsp90. This interaction was modeled on a demonstrated interaction between EGFR from an unspecified species and human Hsp90. + + + + 12471035 + + + + + + + + BIND + + + 123277 + + + + + BIND + + + + + 8 + + + + + Protein + + + 29725609 + + + + + NP_005219.2 + + + + + 8 + + + + + GeneID + + + 3320 + + + + + HSP90AA1 + + + + + Protein + + + 40254816 + + + + + NP_005339.2 + + + + + + + + + 2004 + 12 + 16 + 15 + 32 + 0 + + + + + + + + + 2004 + 12 + 16 + 15 + 34 + 0 + + + + + + + + + 254 + Markers (Sequence Tagged Sites/STS) + + + 254 + + + + + UniSTS + + + 85508 + + + + + RH94246 + (e-PCR) + + + + + 255 + Alternate name + stSG52449 + + + + + 254 + + + + + UniSTS + + + 255240 + + + + + HSC215_(7Gr546mb) + (e-PCR) + + + + + 254 + + + + + UniSTS + + + 169737 + + + + + SHGC-106249 + (e-PCR) + + + + + 254 + + + + + UniSTS + + + 69135 + + + + + WI-21765 + (e-PCR) + + + + + 255 + Alternate name + HSA.26591 + + + 255 + Alternate name + RH61758 + + + 255 + Alternate name + STS-R80402 + + + + + 254 + + + + 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2013 + 8 + 12 + 17 + 56 + 0 + + + + + + + + + 2016 + 7 + 26 + 14 + 53 + 0 + + + + + + + + + 254 + Representative Expression + + + 254 + Text Summary + Broad expression in placenta (RPKM 36.6), skin (RPKM 15.6) and 22 other tissues + + + 254 + Tissue List + placenta; skin; thyroid; esophagus; fat; liver; lung; ovary; brain; colon; prostate; endometrium; kidney; urinary bladder; gall bladder; adrenal; salivary gland; stomach; small intestine; testis; spleen; duodenum; appendix; pancreas; + + + 254 + Category + Broad expression + + + + + + + HGNC + + + HGNC:3236 + + + + + LocusID + + + 1956 + + + + + MIM + + + 131550 + + + + + + LOC1956 + involved in cytokine storm inflammatory response + + + + PROP + phenotype + + + PROP + coronavirus related + + + + \ No newline at end of file diff --git a/tests/input/uniprot-P12345.json b/tests/input/uniprot-P12345.json new file mode 100644 index 000000000..e02b1b59e --- /dev/null +++ b/tests/input/uniprot-P12345.json @@ -0,0 +1,1898 @@ +{ + "entryType": "UniProtKB reviewed (Swiss-Prot)", + "primaryAccession": "P12345", + "secondaryAccessions": [ + "G1SKL2" + ], + "uniProtkbId": "AATM_RABIT", + "entryAudit": { + "firstPublicDate": "1989-10-01", + "lastAnnotationUpdateDate": "2023-11-08", + "lastSequenceUpdateDate": "2013-09-18", + "entryVersion": 140, + "sequenceVersion": 2 + }, + "annotationScore": 5, + "organism": { + "scientificName": "Oryctolagus cuniculus", + "commonName": "Rabbit", + "taxonId": 9986, + "lineage": [ + "Eukaryota", + "Metazoa", + "Chordata", + "Craniata", + "Vertebrata", + "Euteleostomi", + "Mammalia", + "Eutheria", + "Euarchontoglires", + "Glires", + "Lagomorpha", + "Leporidae", + "Oryctolagus" + ] + }, + "proteinExistence": "1: Evidence at protein level", + "proteinDescription": { + "recommendedName": { + "fullName": { + "value": "Aspartate aminotransferase, mitochondrial" + }, + "shortNames": [ + { + "value": "mAspAT" + } + ], + "ecNumbers": [ + { + "evidences": [ + { + "evidenceCode": 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Facilitates cellular uptake of long-chain free fatty acids" + } + ], + "commentType": "FUNCTION" + }, + { + "commentType": "CATALYTIC ACTIVITY", + "reaction": { + "name": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate", + "reactionCrossReferences": [ + { + "database": "Rhea", + "id": "RHEA:21824" + }, + { + "database": "ChEBI", + "id": "CHEBI:16452" + }, + { + "database": "ChEBI", + "id": "CHEBI:16810" + }, + { + "database": "ChEBI", + "id": "CHEBI:29985" + }, + { + "database": "ChEBI", + "id": "CHEBI:29991" + } + ], + "ecNumber": "2.6.1.1", + "evidences": [ + { + "evidenceCode": "ECO:0000250", + "source": "UniProtKB", + "id": "P00507" + } + ] + } + }, + { + "commentType": "CATALYTIC ACTIVITY", + "reaction": { + "name": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate", + "reactionCrossReferences": [ + { + "database": "Rhea", + "id": "RHEA:65560" + }, + { + "database": "ChEBI", + "id": "CHEBI:15377" + }, + { + "database": "ChEBI", + "id": "CHEBI:16810" + }, + { + "database": "ChEBI", + "id": "CHEBI:29985" + }, + { + "database": "ChEBI", + "id": "CHEBI:57959" + }, + { + "database": "ChEBI", + "id": "CHEBI:58454" + } + ], + "ecNumber": "2.6.1.7", + "evidences": [ + { + "evidenceCode": "ECO:0000250", + "source": "UniProtKB", + "id": "P00507" + } + ] + } + }, + { + "commentType": "COFACTOR", + "cofactors": [ + { + "name": "pyridoxal 5'-phosphate", + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "cofactorCrossReference": { + "database": "ChEBI", + "id": "CHEBI:597326" + } + } + ] + }, + { + "texts": [ + { + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "value": "Homodimer" + } + ], + "commentType": "SUBUNIT" + }, + { + "commentType": "SUBCELLULAR LOCATION", + "subcellularLocations": [ + { + "location": { + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "value": "Mitochondrion matrix", + "id": "SL-0170" + } + }, + { + "location": { + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "value": "Cell membrane", + "id": "SL-0039" + } + } + ] + }, + { + "texts": [ + { + "value": "In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes" + } + ], + "commentType": "MISCELLANEOUS" + }, + { + "texts": [ + { + "evidences": [ + { + "evidenceCode": "ECO:0000305" + } + ], + "value": "Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family" + } + ], + "commentType": "SIMILARITY" + } + ], + "features": [ + { + "type": "Transit peptide", + "location": { + "start": { + "value": 1, + "modifier": "EXACT" + }, + "end": { + "value": 29, + "modifier": "EXACT" + } + }, + "description": "Mitochondrion", + "evidences": [ + { + "evidenceCode": "ECO:0000269", + "source": "PubMed", + "id": "4030726" + } + ] + }, + { + "type": "Chain", + "location": { + "start": { + "value": 30, + "modifier": "EXACT" + }, + "end": { + "value": 430, + "modifier": "EXACT" + } + }, + "description": "Aspartate aminotransferase, mitochondrial", + "featureId": "PRO_0000123886" + }, + { + "type": "Binding site", + "location": { + "start": { + "value": 65, + "modifier": "EXACT" + }, + "end": { + "value": 65, + "modifier": "EXACT" + } + }, + "description": "", + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "ligand": { + "name": "substrate" + } + }, + { + "type": "Binding site", + "location": { + "start": { + "value": 162, + "modifier": "EXACT" + }, + "end": { + "value": 162, + "modifier": "EXACT" + } + }, + "description": "", + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "ligand": { + "name": "substrate" + } + }, + { + "type": "Binding site", + "location": { + "start": { + "value": 215, + "modifier": "EXACT" + }, + "end": { + "value": 215, + "modifier": "EXACT" + } + }, + "description": "", + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "ligand": { + "name": "substrate" + } + }, + { + "type": "Binding site", + "location": { + "start": { + "value": 407, + "modifier": "EXACT" + }, + "end": { + "value": 407, + "modifier": "EXACT" + } + }, + "description": "", + "evidences": [ + { + "evidenceCode": "ECO:0000250" + } + ], + "ligand": { + "name": "substrate" + } + }, + { + "type": "Modified residue", + "location": { + "start": { + "value": 48, + "modifier": "EXACT" + }, + "end": { + "value": 48, + "modifier": "EXACT" + } + }, + "description": "Phosphothreonine", + "evidences": [ + { + "evidenceCode": "ECO:0000250", + "source": "UniProtKB", + "id": "P00505" + } + ] + }, + { + "type": "Modified residue", + "location": { + "start": { + "value": 59, + "modifier": "EXACT" + }, + "end": { + "value": 59, + "modifier": "EXACT" + } + }, + "description": "N6-acetyllysine", + "evidences": [ + { + "evidenceCode": "ECO:0000250", + "source": "UniProtKB", + "id": "P05202" + } + ] + }, + { + "type": "Modified residue", + "location": { + "start": { + "value": 73, + "modifier": "EXACT" + }, + "end": { + "value": 73, + "modifier": "EXACT" + } + }, + "description": "N6-acetyllysine; 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"database": "PRINTS", + "id": "PR00799", + "properties": [ + { + "key": "EntryName", + "value": "TRANSAMINASE" + } + ] + }, + { + "database": "SUPFAM", + "id": "SSF53383", + "properties": [ + { + "key": "EntryName", + "value": "PLP-dependent transferases" + }, + { + "key": "MatchStatus", + "value": "1" + } + ] + }, + { + "database": "PROSITE", + "id": "PS00105", + "properties": [ + { + "key": "EntryName", + "value": "AA_TRANSFER_CLASS_1" + }, + { + "key": "MatchStatus", + "value": "1" + } + ] + } + ], + "sequence": { + "value": "MALLHSARVLSGVASAFHPGLAAAASARASSWWAHVEMGPPDPILGVTEAYKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKGLDKEYLPIGGLAEFCRASAELALGENSEVVKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQSYRYYDPKTCGFDFTGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVICKDADEAKRVESQLKILIRPMYSNPPIHGARIASTILTSPDLRKQWLQEVKGMADRIIGMRTQLVSNLKKEGSTHSWQHITDQIGMFCFTGLKPEQVERLTKEFSIYMTKDGRISVAGVTSGNVGYLAHAIHQVTK", + "length": 430, + "molWeight": 47409, + "crc64": "12F54284974D27A5", + "md5": "CF84DAC1BDDD05632A89E4C1F186D0D3" + }, + "extraAttributes": { + "countByCommentType": { + "FUNCTION": 1, + "CATALYTIC ACTIVITY": 2, + "COFACTOR": 1, + "SUBUNIT": 1, + "SUBCELLULAR LOCATION": 1, + "MISCELLANEOUS": 1, + "SIMILARITY": 1 + }, + "countByFeatureType": { + "Transit peptide": 1, + "Chain": 1, + "Binding site": 4, + "Modified residue": 37 + }, + "uniParcId": "UPI0001C61C61" + } +} diff --git a/tests/test_implementations/test_ncbigene.py b/tests/test_implementations/test_ncbigene.py new file mode 100644 index 000000000..726654836 --- /dev/null +++ b/tests/test_implementations/test_ncbigene.py @@ -0,0 +1,46 @@ +import unittest +from xml.etree import ElementTree # noqa S405 + +from oaklib import get_adapter +from oaklib.implementations import NCBIGeneImplementation +from oaklib.interfaces.association_provider_interface import ( + AssociationProviderInterface, +) +from tests import CYTOPLASM, INPUT_DIR + +GENE_PATH = INPUT_DIR / "ncbigene-1956.xml" + + +# TODO: use mock tests +class TestNCBIGene(unittest.TestCase): + """ + Tests :ref:`NCBIGeneImplementation` + """ + + def setUp(self) -> None: + self.adapter = get_adapter("NCBIGene:") + + def test_query(self): + """Tests basic query.""" + adapter = self.adapter + if not isinstance(adapter, AssociationProviderInterface): + raise TypeError("adapter is not an AssociationProviderInterface") + assocs = list(adapter.associations(subjects=["NCBIGene:1956"])) + self.assertGreater(len(assocs), 0) + + def test_parse_gene_xml(self): + """Tests parsing gene XML.""" + adapter = self.adapter + root = ElementTree.parse(str(GENE_PATH)).getroot() # noqa S314 + if not isinstance(adapter, NCBIGeneImplementation): + raise AssertionError + assocs = list(adapter.associations_from_xml("NCBIGene:1956", root)) + self.assertGreater(len(assocs), 0) + self.assertEqual(assocs[0].subject, "NCBIGene:1956") + found = 0 + for assoc in assocs: + if assoc.object == CYTOPLASM: + if set(assoc.publications) == {"PMID:7588596", "PMID:12435727", "PMID:22298428"}: + if assoc.evidence_type == "IDA": + found += 1 + self.assertEqual(found, 1) diff --git a/tests/test_implementations/test_uniprot.py b/tests/test_implementations/test_uniprot.py new file mode 100644 index 000000000..4832ff4dc --- /dev/null +++ b/tests/test_implementations/test_uniprot.py @@ -0,0 +1,38 @@ +import json +import unittest + +from oaklib import get_adapter +from oaklib.implementations import UniprotImplementation +from oaklib.interfaces.association_provider_interface import ( + AssociationProviderInterface, +) +from tests import INPUT_DIR + +PROTEIN_PATH = INPUT_DIR / "uniprot-P12345.json" + + +# TODO: use mock tests +class TestUniprot(unittest.TestCase): + """ + Tests :ref:`UniprotImplementation` + """ + + def setUp(self) -> None: + self.adapter = get_adapter("uniprot:") + + def test_query(self): + """Tests basic query.""" + adapter = self.adapter + if not isinstance(adapter, AssociationProviderInterface): + raise TypeError("adapter is not an AssociationProviderInterface") + assocs = list(adapter.associations(subjects=["UniProtKB:P12345"])) + self.assertGreater(len(assocs), 0) + + def test_parse_uniprot_json(self): + adapter = self.adapter + obj = json.load(open(str(PROTEIN_PATH))) + if not isinstance(adapter, UniprotImplementation): + raise AssertionError + assocs = list(adapter._parse_uniprot_json("UniProtKB:P12345", obj)) + for assoc in assocs: + print(assoc)