Can HematoMap be extended to other hematologic diseases like anemia?

[majeex233]

Hi,

I am interested in using HematoMap for analyzing other hematologic diseases, such as anemia. Given that HematoMap is designed for mapping leukemia cells onto the hematopoietic hierarchy, I am curious if it can be adapted or extended to study other conditions like anemia.

Specifically, I would like to know:

1. Whether the current framework of HematoMap can support analysis of diseases like anemia.
2. If there are any plans to expand the scope of HematoMap to include other hematologic diseases.
3. Any recommendations or resources for adapting HematoMap for such purposes.

Thank you for your time and consideration.

Best regards,
Bella

[ytdai]

Dear Bella,

Thank you very much for your message.

Currently, HematoMap has shown good performance in analyzing acute leukemia. However, for conditions where there is no significant abnormality at the HSPC stage, such as rheumatic diseases or anemia, its performance is more modest.

We are in the process of expanding our dataset by integrating HSPC data from both bone marrow and peripheral blood from various public sources. This comprehensive dataset will help us better understand early differentiation abnormalities in various hematologic diseases.

In the meantime, you might find it useful to refer to the data presented in this study (https://pubmed.ncbi.nlm.nih.gov/38514887/), which focuses on single-cell sequencing of CD34+ cells with a large cell count.

Thank you again for your interest.

Best regards,

Yuting