-
Notifications
You must be signed in to change notification settings - Fork 1
/
Copy pathnews.php
67 lines (66 loc) · 6.74 KB
/
news.php
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
<?php require_once('header.php'); ?>
<h1 property="dc:title" datatype="">News</h1>
<div class="content clearfix">
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded">
<div style="margin-left:20px; float: right">November 23th, 2012</div>
<h1>Powerful tool for identifying unknown metabolites</h1>
<a href="http://www.nbic.nl/uploads/media/Interface9.pdf" target="_blank"><img style="border: thin solid #dcdcdc; float: right; margin: 2px 0 10px 10px;" src="./img/metitree_interface_nov_2012.jpg"></a>
<b>An interview with <a href="http://www.linkedin.com/pub/theo-reijmers/42/811/260" target="_blank">T.Reijmers</a> about Metitree in NBIC's magazine Interface</b><br /><br />
Contemporary metabolomics research is faced with great challenges. Individual metabolites in complex mixtures need to be analysed and identified. Liquid chromatography combined with multistage mass spectrometry (MSn) appears to be a useful approach, especially since the availability of a promising tool for organising, processing, sharing, visualising and comparing MSn data.<br /><br />
<b>Acknowledgement</b><br />
NBIC magazine Interface ( - <i>page 17</i> - )<br /><br />
More about NBIC's Interface magazine can be found and downloaded from: <a href="http://www.nbic.nl/about-nbic/news-press/nbic-magazine/" target="_blank">http://www.nbic.nl/about-nbic/news-press/nbic-magazine/</a>
<br /><br />
<a href="./resources/IF9_p17.pdf" target="_blank">download issue 9 - page 17 | November 2012 <img width="45px" style="border: thin solid #dcdcdc;" src="./img/adobe_pdf_icon.png"></a>
</div>
<div style="margin: 60px 0;"><hr></div>
<div class="field-item even" property="content:encoded">
<div style="margin-left:20px; float: right">November 16th, 2012</div>
<h1>An automated Metabolite Identification Pipeline using Mass Spectral Trees</h1>
<a href="./resources/Montreux2012_MI.pdf" target="_blank"><img style="border: thin solid #dcdcdc; float: right; margin: 2px 0 10px 10px;" src="./img/msn_montreux_2012.jpg"></a>
Identifying metabolites has been reported as one of the major bottlenecks in metabolomics. In part, this is due to the absence of
good computational tools to automate metabolite identification. To address this issue, we have developed mathematical tools to
process and compare multi-stage mass spectrometry data (MSn), in order to extract as much as possible information from the
fragmentation trees. In addition, candidate structures are generated computationally and filters are used to reject improbable
chemical structures. This poster presents the integrated use of these tools in a pipeline fashion to identify metabolites in human
urine.<br />
<a href="./resources/Montreux2012_MI.pdf" target="_blank">read more...</a><br /><br />
<a href="http://www.linkedin.com/pub/theo-reijmers/42/811/260" target="_blank">Theo Reijmers</a> (1),
<a href="http://nl.linkedin.com/in/juliopeironcely" target="_blank">Julio Peironcely</a> (1,2),
<a href="http://www.linkedin.com/in/miquelrojascherto" target="_blank">Miguel Rojas-Cherto</a> (1),
<a href="http://nl.linkedin.com/pub/piotr-kasper/15/b95/256" target="_blank">Piotr Kasper</a> (1),
<a href="nl.linkedin.com/pub/leon-coulier/6/8a2/648" target="_blank">Leon Coulier</a> (2),
Albert Tas (2),
<a href="nl.linkedin.com/pub/rob-vreeken/2/631/41b" target="_blank">Rob Vreeken</a> (1) and
<a href="http://www.linkedin.com/pub/thomas-hankemeier/23/bab/a51" target="_blank">Thomas Hankemeier</a> (1)
<br /><br />
<i><b>1</b>. <a href="http://analyticalbiosciences.leidenuniv.nl/" taget="_blank">Analytical Biosciences, Leiden University</a>, </i>
<i><b>2</b>. <a href="http://www.tno.nl/" taget="_blank">TNO Quality of Life, Zeist</a></i>
</div>
<div style="margin: 60px 0;"><hr></div>
<div class="field-item even" property="content:encoded">
<div style="margin-left:20px; float: right">October 4th, 2012</div>
<h1>MSn spectral tree databases: annotation and identification of plant metabolites</h1>
<a href="./resources/Metabomeeting2012_September10_JJJvdHooft.pdf" target="_blank"><img style="border: thin solid #dcdcdc; float: right; margin: 2px 0 10px 10px;" src="./img/Metabomeeting2012_September10_JJJvdHooft.jpg"></a>
Annotation and identification of metabolites detected in untargeted liquid chromatography coupled to mass spectrometry (LC-MS) profiling
techniques is still a major challenge that needs to be overcome in order to interpret the results obtained in a biological context. Protocols for
generating MSn and LC-MSn data from metabolites detectable in plants, including Arabidopsis leaves and tomato fruit, have recently been
developed, resulting in robust spectral trees [1,2]. Meanwhile, a software tool called MEF has been developed to process the MSn raw data and
assign elemental formulas to the detected metabolite MSn signals [3]. Very recently, a web-based program called MetiTree, embedding the MEF
tool and algorithms to visualize and compare spectral trees [4] has become available [5].<br />
<a href="./resources/Metabomeeting2012_September10_JJJvdHooft.pdf" target="_blank">read more...</a><br /><br />
<a href="http://www.linkedin.com/pub/justin-van-der-hooft/35/a93/9aa" target="_blank">Justin J.J. van der Hooft</a> (1,2,3),
<a href="http://www.linkedin.com/in/miquelrojascherto" target="_blank">Miguel Rojas-Cherto</a> (3),
<a href="http://www.linkedin.com/pub/thomas-hankemeier/23/bab/a51" target="_blank">Thomas Hankemeier</a> (3),
<a href="http://www.linkedin.com/in/michaelvanvliet" target="_blank">Michael van Vliet</a> (3),
<a href="http://www.linkedin.com/pub/theo-reijmers/42/811/260" target="_blank">Theo Reijmers</a> (3),
<a href="http://www.linkedin.com/pub/robert-hall/2/792/88" target="_blank">Robert D. Hall</a> (1,2,3) and
<a href="http://www.linkedin.com/pub/ric-de-vos/17/601/309" taget="_blank">Ric C.H. de Vos</a> (1,2,3)<br /><br />
<i><b>1</b>. <a href="http://www.wageningenur.nl/nl/Expertises-Dienstverlening/Onderzoeksinstituten/Plant-Research-International.htm" target="_blank">Plant Research International, Wageningen-UR, Wageningen, The Netherlands</a>; <b>2</b>. <a href="http://www.cbsg.nl/" target="_blank">Centre for BioSystems Genomics, Wageningen, The Netherlands</a>; <b>3</b>. <a href="http://www.metabolomicscentre.nl/" target="_blank">Netherlands Metabolomics Centre, Leiden, The Netherlands</a></i>
</div>
</div>
</div>
</div>
<?php require_once('footer.php'); ?>