Node.js

$ npm install vhost

var vhost = require('vhost')

var connect = require('connect')
var vhost = require('vhost')
var app = connect()

app.use(vhost('*.*.example.com', function handle (req, res, next) {
  // for match of "foo.bar.example.com:8080" against "*.*.example.com":
  console.dir(req.vhost.host) // => 'foo.bar.example.com:8080'
  console.dir(req.vhost.hostname) // => 'foo.bar.example.com'
  console.dir(req.vhost.length) // => 2
  console.dir(req.vhost[0]) // => 'foo'
  console.dir(req.vhost[1]) // => 'bar'
}))

var connect = require('connect')
var serveStatic = require('serve-static')
var vhost = require('vhost')

var mailapp = connect()

// add middlewares to mailapp for mail.example.com

// create app to serve static files on subdomain
var staticapp = connect()
staticapp.use(serveStatic('public'))

// create main app
var app = connect()

// add vhost routing to main app for mail
app.use(vhost('mail.example.com', mailapp))

// route static assets for "assets-*" subdomain to get
// around max host connections limit on browsers
app.use(vhost('assets-*.example.com', staticapp))

// add middlewares and main usage to app

app.listen(3000)

var connect = require('connect')
var serveStatic = require('serve-static')
var vhost = require('vhost')

var mainapp = connect()

// add middlewares to mainapp for the main web site

// create app that will server user content from public/{username}/
var userapp = connect()

userapp.use(function (req, res, next) {
  var username = req.vhost[0] // username is the "*"

  // pretend request was for /{username}/* for file serving
  req.originalUrl = req.url
  req.url = '/' + username + req.url

  next()
})
userapp.use(serveStatic('public'))

// create main app
var app = connect()

// add vhost routing for main app
app.use(vhost('userpages.local', mainapp))
app.use(vhost('www.userpages.local', mainapp))

// listen on all subdomains for user pages
app.use(vhost('*.userpages.local', userapp))

app.listen(3000)

var connect = require('connect')
var serveStatic = require('serve-static')
var vhost = require('vhost')

var mainapp = connect()

// add middlewares to mainapp for the main web site

// create app that will server user content from public/{username}/
var userapp = connect()

userapp.use(function (req, res, next) {
  var username = req.vhost[0] // username is the "*"

  // pretend request was for /{username}/* for file serving
  req.originalUrl = req.url
  req.url = '/' + username + req.url

  next()
})
userapp.use(serveStatic('public'))

// create main app
var app = connect()

// add vhost routing for main app
app.use(vhost('userpages.local', mainapp))
app.use(vhost('www.userpages.local', mainapp))

// listen on all subdomains for user pages
app.use(vhost('*.userpages.local', userapp))

app.listen(3000)

var connect = require('connect')
var http = require('http')
var vhost = require('vhost')

// create main app
var app = connect()

app.use(vhost('mail.example.com', function (req, res) {
  // handle req + res belonging to mail.example.com
  res.setHeader('Content-Type', 'text/plain')
  res.end('hello from mail!')
}))

// an external api server in any framework
var httpServer = http.createServer(function (req, res) {
  res.setHeader('Content-Type', 'text/plain')
  res.end('hello from the api!')
})

app.use(vhost('api.example.com', function (req, res) {
  // handle req + res belonging to api.example.com
  // pass the request to a standard Node.js HTTP server
  httpServer.emit('request', req, res)
}))

app.listen(3000