diff --git a/src/python_interpreter/config.rs b/src/python_interpreter/config.rs
index 8f8838870..ef6560108 100644
--- a/src/python_interpreter/config.rs
+++ b/src/python_interpreter/config.rs
@@ -432,6 +432,25 @@ mod test {
         .unwrap();
         assert_eq!(sysconfig.ext_suffix, ".cpython-310-powerpc-linux-gnu.so");
 
+        let sysconfig = InterpreterConfig::lookup_one(
+            &Target::from_target_triple(Some("mips64-unknown-linux-gnu".to_string())).unwrap(),
+            InterpreterKind::CPython,
+            (3, 10),
+        )
+        .unwrap();
+        assert_eq!(
+            sysconfig.ext_suffix,
+            ".cpython-310-mips64-linux-gnuabi64.so"
+        );
+
+        let sysconfig = InterpreterConfig::lookup_one(
+            &Target::from_target_triple(Some("mips-unknown-linux-gnu".to_string())).unwrap(),
+            InterpreterKind::CPython,
+            (3, 10),
+        )
+        .unwrap();
+        assert_eq!(sysconfig.ext_suffix, ".cpython-310-mips-linux-gnu.so");
+
         let sysconfig = InterpreterConfig::lookup_one(
             &Target::from_target_triple(Some("s390x-unknown-linux-gnu".to_string())).unwrap(),
             InterpreterKind::CPython,
diff --git a/src/target.rs b/src/target.rs
index 93afd9bb2..25fc6c07f 100644
--- a/src/target.rs
+++ b/src/target.rs
@@ -396,7 +396,9 @@ impl Target {
         match python_impl {
             CPython => {
                 // For musl handling see https://github.com/pypa/auditwheel/issues/349
-                if python_version >= (3, 11) {
+                if matches!(self.target_arch(), Arch::Mips64 | Arch::Mips64el) && self.is_linux() {
+                    "gnuabi64".to_string()
+                } else if python_version >= (3, 11) {
                     self.target_env().to_string()
                 } else {
                     self.target_env().to_string().replace("musl", "gnu")