diff --git a/Dockerfile.rocm b/Dockerfile.rocm
index 02d37cdc6a1c8..e97762163e2eb 100644
--- a/Dockerfile.rocm
+++ b/Dockerfile.rocm
@@ -46,12 +46,12 @@ WORKDIR ${APP_MOUNT}
 RUN python3 -m pip install --upgrade pip
 # Remove sccache so it doesn't interfere with ccache
 # TODO: implement sccache support across components
-RUN apt-get purge -y sccache; pip uninstall -y sccache; rm -f "$(which sccache)"
+RUN apt-get purge -y sccache; python3 -m pip uninstall -y sccache; rm -f "$(which sccache)"
 # Install torch == 2.5.0 on ROCm
 RUN case "$(ls /opt | grep -Po 'rocm-[0-9]\.[0-9]')" in \
         *"rocm-6.1"*) \
-            pip uninstall -y torch torchaudio torchvision \
-            && pip install --no-cache-dir --pre \
+            python3 -m pip uninstall -y torch torchaudio torchvision \
+            && python3 -m pip install --no-cache-dir --pre \
                 torch==2.5.0.dev20240710 torchaudio==2.4.0.dev20240710 \
                 torchvision==0.20.0.dev20240710 \
                --index-url https://download.pytorch.org/whl/nightly/rocm6.1;; \
@@ -70,7 +70,7 @@ ENV CCACHE_DIR=/root/.cache/ccache
 FROM base AS build_amdsmi
 # Build amdsmi wheel always
 RUN cd /opt/rocm/share/amd_smi \
-    && pip wheel . --wheel-dir=/install
+    && python3 -m pip wheel . --wheel-dir=/install
 
 
 ### Flash-Attention wheel build stage
@@ -126,7 +126,7 @@ RUN case "$(which python3)" in \
 
 # Package upgrades for useful functionality or to avoid dependency issues
 RUN --mount=type=cache,target=/root/.cache/pip \
-    pip install --upgrade numba scipy huggingface-hub[cli]
+    python3 -m pip install --upgrade numba scipy huggingface-hub[cli]
 
 # Make sure punica kernels are built (for LoRA)
 ENV VLLM_INSTALL_PUNICA_KERNELS=1
@@ -137,7 +137,7 @@ ENV TOKENIZERS_PARALLELISM=false
 
 RUN --mount=type=cache,target=${CCACHE_DIR} \
     --mount=type=cache,target=/root/.cache/pip \
-    pip install -Ur requirements-rocm.txt \
+    python3 -m pip install -Ur requirements-rocm.txt \
     && case "$(ls /opt | grep -Po 'rocm-[0-9]\.[0-9]')" in \
         *"rocm-6.1"*) \
             # Bring in upgrades to HIP graph earlier than ROCm 6.2 for vLLM
@@ -153,7 +153,7 @@ RUN --mount=type=bind,from=build_amdsmi,src=/install,target=/install \
     mkdir -p libs \
     && cp /install/*.whl libs \
     # Preemptively uninstall to avoid same-version no-installs
-    && pip uninstall -y amdsmi;
+    && python3 -m pip uninstall -y amdsmi;
 
 # Copy triton wheel(s) into final image if they were built
 RUN --mount=type=bind,from=build_triton,src=/install,target=/install \
@@ -161,7 +161,7 @@ RUN --mount=type=bind,from=build_triton,src=/install,target=/install \
     && if ls /install/*.whl; then \
         cp /install/*.whl libs \
         # Preemptively uninstall to avoid same-version no-installs
-        && pip uninstall -y triton; fi
+        && python3 -m pip uninstall -y triton; fi
 
 # Copy flash-attn wheel(s) into final image if they were built
 RUN --mount=type=bind,from=build_fa,src=/install,target=/install \
@@ -169,11 +169,11 @@ RUN --mount=type=bind,from=build_fa,src=/install,target=/install \
     && if ls /install/*.whl; then \
         cp /install/*.whl libs \
         # Preemptively uninstall to avoid same-version no-installs
-        && pip uninstall -y flash-attn; fi
+        && python3 -m pip uninstall -y flash-attn; fi
 
 # Install wheels that were built to the final image
 RUN --mount=type=cache,target=/root/.cache/pip \
     if ls libs/*.whl; then \
-    pip install libs/*.whl; fi
+    python3 -m pip install libs/*.whl; fi
 
 CMD ["/bin/bash"]