diff --git a/code/ARAX/ARAXQuery/ARAX_expander.py b/code/ARAX/ARAXQuery/ARAX_expander.py index 246096a52..1a9a927fd 100644 --- a/code/ARAX/ARAXQuery/ARAX_expander.py +++ b/code/ARAX/ARAXQuery/ARAX_expander.py @@ -91,15 +91,15 @@ def describe_me(self): f"google distance (NGD) database to expand " "a query graph; it returns edges between nodes with an NGD value below a certain " "threshold. This threshold is currently hardcoded as 0.5, though this will be made " - "configurable/smarter in the future.\n" - "2. DTD: The 'infores:arax-drug-treats-disease' KP uses ARAX's in-house drug-treats-disease (DTD) database (built from GraphSage model) to expand " - "a query graph; it returns edges between nodes with a DTD probability above a certain " - "threshold. The default threshold is currently set to 0.8. If you set this threshold below 0.8, you should also " - "set DTD_slow_mode=True otherwise a warninig will occur. This is because the current DTD database only stores the pre-calcualted " - "DTD probability above or equal to 0.8. Therefore, if an user set threshold below 0.8, it will automatically switch to call DTD model " - "to do a real-time calculation and this will be quite time-consuming. In addition, if you call DTD database, your query node type would be checked. " - "In other words, the query node has to have a sysnonym which is drug or disease. If you don't want to check node type, set DTD_slow_mode=true " - "to call DTD model to do a real-time calculation.", + "configurable/smarter in the future.\n", + # "2. DTD: The 'infores:arax-drug-treats-disease' KP uses ARAX's in-house drug-treats-disease (DTD) database (built from GraphSage model) to expand " + # "a query graph; it returns edges between nodes with a DTD probability above a certain " + # "threshold. The default threshold is currently set to 0.8. If you set this threshold below 0.8, you should also " + # "set DTD_slow_mode=True otherwise a warninig will occur. This is because the current DTD database only stores the pre-calcualted " + # "DTD probability above or equal to 0.8. Therefore, if an user set threshold below 0.8, it will automatically switch to call DTD model " + # "to do a real-time calculation and this will be quite time-consuming. In addition, if you call DTD database, your query node type would be checked. " + # "In other words, the query node has to have a sysnonym which is drug or disease. If you don't want to check node type, set DTD_slow_mode=true " + # "to call DTD model to do a real-time calculation.", "parameters": self.get_parameter_info_dict() } return [command_definition] @@ -152,26 +152,26 @@ def get_parameter_info_dict(): "description": "Whether to omit supporting data on nodes/edges in the results (e.g., publications, " "description, etc.)." }, - "DTD_threshold": { - "is_required": False, - "examples": [0.8, 0.5], - "min": 0, - "max": 1, - "default": 0.8, - "type": "float", - "description": "Applicable only when the 'infores:arax-drug-treats-disease' KP is used. " - "Defines what cut-off/threshold to use for expanding the DTD virtual edges." - }, - "DTD_slow_mode": { - "is_required": False, - "examples": ["true", "false"], - "enum": ["true", "false", "True", "False", "t", "f", "T", "F"], - "default": "false", - "type": "boolean", - "description": "Applicable only when the 'infores:arax-drug-treats-disease' KP is used. " - "Specifies whether to call DTD model rather than DTD database to do a real-time " - "calculation for DTD probability." - } + # "DTD_threshold": { + # "is_required": False, + # "examples": [0.8, 0.5], + # "min": 0, + # "max": 1, + # "default": 0.8, + # "type": "float", + # "description": "Applicable only when the 'infores:arax-drug-treats-disease' KP is used. " + # "Defines what cut-off/threshold to use for expanding the DTD virtual edges." + # }, + # "DTD_slow_mode": { + # "is_required": False, + # "examples": ["true", "false"], + # "enum": ["true", "false", "True", "False", "t", "f", "T", "F"], + # "default": "false", + # "type": "boolean", + # "description": "Applicable only when the 'infores:arax-drug-treats-disease' KP is used. " + # "Specifies whether to call DTD model rather than DTD database to do a real-time " + # "calculation for DTD probability." + # } } return parameter_info_dict @@ -724,7 +724,7 @@ def apply(self, response, input_parameters, mode: str = "ARAX"): kg = message.knowledge_graph log.info(f"After Expand, the KG has {len(kg.nodes)} nodes and {len(kg.edges)} edges " f"({eu.get_printable_counts_by_qg_id(overarching_kg)})") - + return response async def _expand_edge_async(self, edge_qg: QueryGraph, kp_to_use: str, input_parameters: Dict[str, any], @@ -756,8 +756,10 @@ async def _expand_edge_async(self, edge_qg: QueryGraph, kp_to_use: str, input_pa log.update_query_plan(qedge_key, kp_to_use, "Waiting", waiting_message) start = time.time() if kp_to_use == 'infores:arax-drug-treats-disease': - from Expand.DTD_querier import DTDQuerier - kp_querier = DTDQuerier(log) + # from Expand.DTD_querier import DTDQuerier + # kp_querier = DTDQuerier(log) + log.warning(f"DTD KP has been replaced with xDTD and thus is currently disabled.") + return answer_kg, log else: from Expand.ngd_querier import NGDQuerier kp_querier = NGDQuerier(log) @@ -806,6 +808,8 @@ async def _expand_edge_async(self, edge_qg: QueryGraph, kp_to_use: str, input_pa answer_kg = self._remove_self_edges(answer_kg, kp_to_use, log) return answer_kg, log + + def _expand_edge_kg2_local(self, one_hop_qg: QueryGraph, log: ARAXResponse) -> Tuple[QGOrganizedKnowledgeGraph, ARAXResponse]: qedge_key = next(qedge_key for qedge_key in one_hop_qg.edges) @@ -855,10 +859,10 @@ def _expand_edge(self, edge_qg: QueryGraph, kp_to_use: str, input_parameters: Di # Route this query to the proper place depending on the KP try: - if kp_to_use == 'infores:arax-drug-treats-disease': - from Expand.DTD_querier import DTDQuerier - kp_querier = DTDQuerier(log) - elif kp_to_use == 'infores:arax-normalized-google-distance': + # if kp_to_use == 'infores:arax-drug-treats-disease': + # from Expand.DTD_querier import DTDQuerier + # kp_querier = DTDQuerier(log) + if kp_to_use == 'infores:arax-normalized-google-distance': from Expand.ngd_querier import NGDQuerier kp_querier = NGDQuerier(log) else: diff --git a/code/ARAX/ARAXQuery/ARAX_overlay.py b/code/ARAX/ARAXQuery/ARAX_overlay.py index bd0fa694c..f7954a8b0 100644 --- a/code/ARAX/ARAXQuery/ARAX_overlay.py +++ b/code/ARAX/ARAXQuery/ARAX_overlay.py @@ -30,7 +30,7 @@ def __init__(self): 'overlay_clinical_info', 'compute_jaccard', 'add_node_pmids', - 'predict_drug_treats_disease', + # 'predict_drug_treats_disease', 'fisher_exact_test', 'overlay_exposures_data' } @@ -291,37 +291,37 @@ def __init__(self): 'max_num': self.max_num_info } }, - "predict_drug_treats_disease": { - "dsl_command": "overlay(action=predict_drug_treats_disease)", - "description": """ -`predict_drug_treats_disease` utilizes a machine learning model (trained on KP ARAX/KG1) to assign a probability that a given drug/chemical_substance treats a disease/phenotypic feature. -For more information about how this model was trained and how it performs, please see [this publication](https://doi.org/10.1101/765305). -The drug-disease treatment prediction probability is included as an edge attribute (with the attribute name `probability_treats`). -You have the choice of applying this to all appropriate edges in the knowledge graph, or only between specified subject/object qnode id's (make sure one is a chemical_substance, and the other is a disease or phenotypic_feature). -If the later, virtual edges are added with the relation specified by `virtual_edge_type` and the type `probably_treats`. -Use cases include: - -* Overlay drug the probability of any drug in your knowledge graph treating any disease via `overlay(action=predict_drug_treats_disease)` -* For specific drugs and diseases/phenotypes in your graph, add the probability that the drug treats them with something like `overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1)` -* Subsequently remove low-probability treating drugs with `overlay(action=predict_drug_treats_disease)` followed by `filter_kg(action=remove_edges_by_attribute, edge_attribute=probability_treats, direction=below, threshold=.6, remove_connected_nodes=t, qnode_key=n02)` - -This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). - """, - 'brief_description': """ -predict_drug_treats_disease utilizes a machine learning model (trained on KP RTX-KG2C) to assign a probability that a given drug/chemical_substance treats a disease/phenotypic feature. -For more information about how this model was trained and how it performs, please see this publication (https://doi.org/10.1101/765305) for the version trained on KG1 which used node2vec for its -embeddings. The current version uses KG2C; publication in preparation. -The drug-disease treatment prediction probability is included as an edge attribute (with the attribute name 'probability_treats'). -You have the choice of applying this to all appropriate edges in the knowledge graph, or only between specified subject/object qnode id's (make sure one is a chemical_substance, and the other is a disease or phenotypic_feature). - """, - "parameters": { - 'virtual_relation_label': self.virtual_relation_label_info, - 'subject_qnode_key': self.subject_qnode_key_info, - 'object_qnode_key': self.object_qnode_key_info, - 'threshold': self.dtd_threshold_info, - 'slow_mode': self.dtd_slow_mode_info - } - }, +# "predict_drug_treats_disease": { +# "dsl_command": "overlay(action=predict_drug_treats_disease)", +# "description": """ +# `predict_drug_treats_disease` utilizes a machine learning model (trained on KP ARAX/KG1) to assign a probability that a given drug/chemical_substance treats a disease/phenotypic feature. +# For more information about how this model was trained and how it performs, please see [this publication](https://doi.org/10.1101/765305). +# The drug-disease treatment prediction probability is included as an edge attribute (with the attribute name `probability_treats`). +# You have the choice of applying this to all appropriate edges in the knowledge graph, or only between specified subject/object qnode id's (make sure one is a chemical_substance, and the other is a disease or phenotypic_feature). +# If the later, virtual edges are added with the relation specified by `virtual_edge_type` and the type `probably_treats`. +# Use cases include: + +# * Overlay drug the probability of any drug in your knowledge graph treating any disease via `overlay(action=predict_drug_treats_disease)` +# * For specific drugs and diseases/phenotypes in your graph, add the probability that the drug treats them with something like `overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1)` +# * Subsequently remove low-probability treating drugs with `overlay(action=predict_drug_treats_disease)` followed by `filter_kg(action=remove_edges_by_attribute, edge_attribute=probability_treats, direction=below, threshold=.6, remove_connected_nodes=t, qnode_key=n02)` + +# This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). +# """, +# 'brief_description': """ +# predict_drug_treats_disease utilizes a machine learning model (trained on KP RTX-KG2C) to assign a probability that a given drug/chemical_substance treats a disease/phenotypic feature. +# For more information about how this model was trained and how it performs, please see this publication (https://doi.org/10.1101/765305) for the version trained on KG1 which used node2vec for its +# embeddings. The current version uses KG2C; publication in preparation. +# The drug-disease treatment prediction probability is included as an edge attribute (with the attribute name 'probability_treats'). +# You have the choice of applying this to all appropriate edges in the knowledge graph, or only between specified subject/object qnode id's (make sure one is a chemical_substance, and the other is a disease or phenotypic_feature). +# """, +# "parameters": { +# 'virtual_relation_label': self.virtual_relation_label_info, +# 'subject_qnode_key': self.subject_qnode_key_info, +# 'object_qnode_key': self.object_qnode_key_info, +# 'threshold': self.dtd_threshold_info, +# 'slow_mode': self.dtd_slow_mode_info +# } +# }, "fisher_exact_test": { "dsl_command": "overlay(action=fisher_exact_test)", "description": """ @@ -799,66 +799,66 @@ def __compute_jaccard(self, describe=False): response = JAC.compute_jaccard() return response - def __predict_drug_treats_disease(self, describe=False): - """ - Utilizes a machine learning model to predict if a given chemical_substance treats a disease or phenotypic_feature - Allowable parameters: - :return: - """ - message = self.message - parameters = self.parameters - # make a list of the allowable parameters (keys), and their possible values (values). Note that the action and corresponding name will always be in the allowable parameters - if message and parameters and hasattr(message, 'query_graph') and hasattr(message.query_graph, 'edges'): - qg_nodes = message.query_graph.nodes - allowable_parameters = {'action': {'predict_drug_treats_disease'}, 'virtual_relation_label': { - self.parameters['virtual_relation_label'] if 'virtual_relation_label' in self.parameters else None}, - # 'subject_qnode_key': set([k for k, x in self.message.query_graph.nodes.items() if x.category == "chemical_substance"]), - 'subject_qnode_key': set([node_key for node_key in qg_nodes.keys()]), - # allow any query node type, will be handled by predict_drug_treats_disease.py - # 'object_qnode_key': set([k for k, x in self.message.query_graph.nodes.items() if (x.category == "disease" or x.category == "phenotypic_feature")]) - 'object_qnode_key': set([node_key for node_key in qg_nodes.keys()]), - 'threshold': [None, int(), float()], - # allow any query node type, will be handled by predict_drug_treats_disease.py - 'slow_mode': ["true", "false", "True", "False", "t", "f", "T", "F"] - } - else: - allowable_parameters = {'action': {'predict_drug_treats_disease'}, 'virtual_relation_label': { - 'optional: any string label that identifies the virtual edges added (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, - 'subject_qnode_key': { - 'optional: a specific subject query node id corresponding to a disease query node (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, - 'object_qnode_key': { - 'optional: a specific object query node id corresponding to a disease or phenotypic_feature query node (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, - 'threshold': { - 'optional: What cut-off/threshold to use for DTD probability (default is 0.8)'}, - 'slow_mode': { - 'optional: Whether to call DTD model rather than DTD database to do a real-time calculation for DTD probability (default is False)'} - } - - # A little function to describe what this thing does - if describe: - description_dict = self.command_definitions['predict_drug_treats_disease'] - return description_dict - - # Make sure only allowable parameters and values have been passed - self.check_params(allowable_parameters) - # return if bad parameters have been passed - if self.response.status != 'OK': - return self.response - # Check if all virtual edge params have been provided properly - # self.check_virtual_edge_params(allowable_parameters) - # FW: changing this to only check if subject_qnode_key or object_qnode_key is present - if 'subject_qnode_key' in parameters or 'object_qnode_key' in parameters: - self.check_virtual_edge_params(allowable_parameters) - if self.response.status != 'OK': - return self.response - - # now do the call out to NGD - from Overlay.predict_drug_treats_disease import PredictDrugTreatsDisease - PDTD = PredictDrugTreatsDisease(self.response, self.message, parameters) - if PDTD.response.status != 'OK': - return PDTD.response - response = PDTD.predict_drug_treats_disease() - return response + # def __predict_drug_treats_disease(self, describe=False): + # """ + # Utilizes a machine learning model to predict if a given chemical_substance treats a disease or phenotypic_feature + # Allowable parameters: + # :return: + # """ + # message = self.message + # parameters = self.parameters + # # make a list of the allowable parameters (keys), and their possible values (values). Note that the action and corresponding name will always be in the allowable parameters + # if message and parameters and hasattr(message, 'query_graph') and hasattr(message.query_graph, 'edges'): + # qg_nodes = message.query_graph.nodes + # allowable_parameters = {'action': {'predict_drug_treats_disease'}, 'virtual_relation_label': { + # self.parameters['virtual_relation_label'] if 'virtual_relation_label' in self.parameters else None}, + # # 'subject_qnode_key': set([k for k, x in self.message.query_graph.nodes.items() if x.category == "chemical_substance"]), + # 'subject_qnode_key': set([node_key for node_key in qg_nodes.keys()]), + # # allow any query node type, will be handled by predict_drug_treats_disease.py + # # 'object_qnode_key': set([k for k, x in self.message.query_graph.nodes.items() if (x.category == "disease" or x.category == "phenotypic_feature")]) + # 'object_qnode_key': set([node_key for node_key in qg_nodes.keys()]), + # 'threshold': [None, int(), float()], + # # allow any query node type, will be handled by predict_drug_treats_disease.py + # 'slow_mode': ["true", "false", "True", "False", "t", "f", "T", "F"] + # } + # else: + # allowable_parameters = {'action': {'predict_drug_treats_disease'}, 'virtual_relation_label': { + # 'optional: any string label that identifies the virtual edges added (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, + # 'subject_qnode_key': { + # 'optional: a specific subject query node id corresponding to a disease query node (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, + # 'object_qnode_key': { + # 'optional: a specific object query node id corresponding to a disease or phenotypic_feature query node (otherwise applied to all drug->disease and drug->phenotypic_feature edges)'}, + # 'threshold': { + # 'optional: What cut-off/threshold to use for DTD probability (default is 0.8)'}, + # 'slow_mode': { + # 'optional: Whether to call DTD model rather than DTD database to do a real-time calculation for DTD probability (default is False)'} + # } + + # # A little function to describe what this thing does + # if describe: + # description_dict = self.command_definitions['predict_drug_treats_disease'] + # return description_dict + + # # Make sure only allowable parameters and values have been passed + # self.check_params(allowable_parameters) + # # return if bad parameters have been passed + # if self.response.status != 'OK': + # return self.response + # # Check if all virtual edge params have been provided properly + # # self.check_virtual_edge_params(allowable_parameters) + # # FW: changing this to only check if subject_qnode_key or object_qnode_key is present + # if 'subject_qnode_key' in parameters or 'object_qnode_key' in parameters: + # self.check_virtual_edge_params(allowable_parameters) + # if self.response.status != 'OK': + # return self.response + + # # now do the call out to NGD + # from Overlay.predict_drug_treats_disease import PredictDrugTreatsDisease + # PDTD = PredictDrugTreatsDisease(self.response, self.message, parameters) + # if PDTD.response.status != 'OK': + # return PDTD.response + # response = PDTD.predict_drug_treats_disease() + # return response def __fisher_exact_test(self, describe=False): @@ -1025,8 +1025,7 @@ def main(): # "overlay(action=compute_jaccard, start_node_key=n00, intermediate_node_key=n01, end_node_key=n02, virtual_edge_type=J1)", # "overlay(action=add_node_pmids)", # "overlay(action=overlay_clinical_info, observed_expected_ratio=true)", - # "overlay(action=overlay_clinical_info, paired_concept_frequency=true, virtual_edge_type=P1, subject_qnode_key=n00, object_qnode_key=n01)", - "overlay(action=predict_drug_treats_disease, subject_qnode_key=n01, object_qnode_key=n00, virtual_edge_type=P1)", + "overlay(action=overlay_clinical_info, paired_concept_frequency=true, virtual_edge_type=P1, subject_qnode_key=n00, object_qnode_key=n01)" "return(message=true,store=false)" ] diff --git a/code/ARAX/ARAXQuery/Expand/expand_utilities.py b/code/ARAX/ARAXQuery/Expand/expand_utilities.py index 7b6a2a36e..12913d354 100644 --- a/code/ARAX/ARAXQuery/Expand/expand_utilities.py +++ b/code/ARAX/ARAXQuery/Expand/expand_utilities.py @@ -600,6 +600,25 @@ def remove_semmeddb_edges_and_nodes_with_low_publications(kg: KnowledgeGraph, lo else: log.info(f"{edges_removed_counter} Semmeddb Edges with low publication count successfully removed") +def filter_response_domain_range_exclusion(plover_answer, qg, log: ARAXResponse): + log.debug("Applying domain range exclusion to plover response") + filtered_count = 0 + qg_edge_keys = qg.edges.keys() + for qg_edge_key in qg_edge_keys: + + edge_keys_to_filter = {edge_id for edge_id, edge in plover_answer['edges'][qg_edge_key].items() if edge[7] == "True"} + for edge_key in edge_keys_to_filter: + del plover_answer['edges'][qg_edge_key][edge_key] + filtered_count += 1 + + log.info(f"Filtered out {filtered_count} edges from response due to domain range exclusion") + + return plover_answer + + + + + def is_expand_created_subclass_qedge_key(qedge_key: str, qg: QueryGraph) -> bool: """ diff --git a/code/ARAX/ARAXQuery/Expand/kg2_querier.py b/code/ARAX/ARAXQuery/Expand/kg2_querier.py index f30c7c265..3fd98b279 100644 --- a/code/ARAX/ARAXQuery/Expand/kg2_querier.py +++ b/code/ARAX/ARAXQuery/Expand/kg2_querier.py @@ -79,7 +79,8 @@ def answer_one_hop_query(self, query_graph: QueryGraph) -> QGOrganizedKnowledgeG query_graph.nodes[input_qnode_key].ids = curie_batch plover_answer, response_status = self._answer_query_using_plover(query_graph, log) if response_status == 200: - batch_kg = self._load_plover_answer_into_object_model(plover_answer, log) + filtered_plover_answer = eu.filter_response_domain_range_exclusion(plover_answer, query_graph, log) + batch_kg = self._load_plover_answer_into_object_model(filtered_plover_answer, log) final_kg = eu.merge_two_kgs(batch_kg, final_kg) # Prune down highly-connected input curies if we're over the max number of allowed edges if final_kg.edges_by_qg_id.get(qedge_key): diff --git a/code/ARAX/ARAXQuery/result_transformer.py b/code/ARAX/ARAXQuery/result_transformer.py index 195ebd0e0..65bac6512 100644 --- a/code/ARAX/ARAXQuery/result_transformer.py +++ b/code/ARAX/ARAXQuery/result_transformer.py @@ -81,7 +81,7 @@ def transform(response: ARAXResponse): else: inferred_qedge_key = inferred_qedge_keys[0] inferred_edge_keys = {edge_binding.id for edge_binding in - result.analyses[0].edge_bindings[inferred_qedge_key]} + result.analyses[0].edge_bindings[inferred_qedge_key] if "creative_" in edge_binding.id} # Refer to the support graph from the proper edge(s) for inferred_edge_key in inferred_edge_keys: inferred_edge = message.knowledge_graph.edges[inferred_edge_key] diff --git a/code/ARAX/BiolinkHelper/biolink_helper.py b/code/ARAX/BiolinkHelper/biolink_helper.py index c37172573..9ed4fcc8b 100644 --- a/code/ARAX/BiolinkHelper/biolink_helper.py +++ b/code/ARAX/BiolinkHelper/biolink_helper.py @@ -4,6 +4,7 @@ """ import argparse +import datetime import json import os import sys @@ -21,14 +22,22 @@ def eprint(*args, **kwargs): print(*args, file=sys.stderr, **kwargs) class BiolinkHelper: def __init__(self, biolink_version: Optional[str] = None, is_test: bool = False): - eprint("DEBUG: In BiolinkHelper init") + timestamp = str(datetime.datetime.now().isoformat()) + eprint(f"{timestamp}: DEBUG: In BiolinkHelper init") + self.biolink_version = biolink_version if biolink_version else self.get_current_arax_biolink_version() self.root_category = "biolink:NamedThing" self.root_predicate = "biolink:related_to" self.root_imaginary = "ROOT" biolink_helper_dir = os.path.dirname(os.path.abspath(__file__)) self.biolink_lookup_map_path = f"{biolink_helper_dir}/biolink_lookup_map_{self.biolink_version}_v4.pickle" + + timestamp = str(datetime.datetime.now().isoformat()) + eprint(f"{timestamp}: DEBUG: Loading BL lookup map...") self.biolink_lookup_map = self._load_biolink_lookup_map(is_test=is_test) + timestamp = str(datetime.datetime.now().isoformat()) + eprint(f"{timestamp}: DEBUG: Done loading BL lookup map") + protein_like_categories = {"biolink:Protein", "biolink:Gene"} disease_like_categories = {"biolink:Disease", "biolink:PhenotypicFeature", "biolink:DiseaseOrPhenotypicFeature"} self.arax_conflations = { @@ -188,23 +197,26 @@ def get_current_arax_biolink_version() -> str: def _load_biolink_lookup_map(self, is_test: bool = False): lookup_map_file = pathlib.Path(self.biolink_lookup_map_path) + timestamp = str(datetime.datetime.now().isoformat()) if is_test or not lookup_map_file.exists(): if is_test: - eprint(f"DEBUG: in test mode") + eprint(f"{timestamp}: DEBUG: in test mode") else: - eprint(f"DEBUG: lookup map not here! {lookup_map_file}") + eprint(f"{timestamp}: DEBUG: lookup map not here! {lookup_map_file}") # Parse the relevant Biolink yaml file and create/save local indexes return self._create_biolink_lookup_map() else: # A local file already exists for this Biolink version, so just load it + eprint(f"{timestamp}: DEBUG: Loading pickle file: {self.biolink_lookup_map_path}") with open(self.biolink_lookup_map_path, "rb") as biolink_map_file: biolink_lookup_map = pickle.load(biolink_map_file) return biolink_lookup_map def _create_biolink_lookup_map(self) -> Dict[str, Dict[str, Dict[str, Union[str, List[str], bool]]]]: - eprint(f"INFO: Building local Biolink {self.biolink_version} ancestor/descendant lookup map because one " - f"doesn't yet exist") + timestamp = str(datetime.datetime.now().isoformat()) + eprint(f"{timestamp}: INFO: Building local Biolink {self.biolink_version} ancestor/descendant lookup map " + f"because one doesn't yet exist") biolink_lookup_map = {"predicates": dict(), "categories": dict(), "predicate_mixins": dict(), "category_mixins": dict(), "aspects": dict(), "directions": dict()} diff --git a/code/ARAX/Documentation/DSL_Documentation.md b/code/ARAX/Documentation/DSL_Documentation.md index decdbc411..a99967f45 100644 --- a/code/ARAX/Documentation/DSL_Documentation.md +++ b/code/ARAX/Documentation/DSL_Documentation.md @@ -9,12 +9,11 @@ - [ARAX_expander](#arax_expander) - [expand()](#expand) - [ARAX_overlay](#arax_overlay) - - [overlay(action=compute_ngd)](#overlayactioncompute_ngd) - - [overlay(action=overlay_exposures_data)](#overlayactionoverlay_exposures_data) - - [overlay(action=fisher_exact_test)](#overlayactionfisher_exact_test) - [overlay(action=compute_jaccard)](#overlayactioncompute_jaccard) - - [overlay(action=predict_drug_treats_disease)](#overlayactionpredict_drug_treats_disease) - [overlay(action=overlay_clinical_info)](#overlayactionoverlay_clinical_info) + - [overlay(action=fisher_exact_test)](#overlayactionfisher_exact_test) + - [overlay(action=compute_ngd)](#overlayactioncompute_ngd) + - [overlay(action=overlay_exposures_data)](#overlayactionoverlay_exposures_data) - [overlay(action=add_node_pmids)](#overlayactionadd_node_pmids) - [ARAX_filter_kg](#arax_filter_kg) - [filter_kg(action=remove_edges_by_predicate)](#filter_kgactionremove_edges_by_predicate) @@ -65,7 +64,7 @@ while initially an empty list, a set of processing actions can be applied with s ## ARAX_messenger ### create_envelope() The `create_envelope` command creates a basic empty Response object with basic boilerplate metadata - such as reasoner_id, schema_version, etc. filled in. This DSL command takes no arguments. This command is not explicitly + such as resource_id, schema_version, etc. filled in. This DSL command takes no arguments. This command is not explicitly necessary, as it is called implicitly when needed. e.g. If a DSL program begins with add_qnode(), the create_envelope() will be executed automatically if there is not yet a ARAXResponse. If there is already ARAXResponse in memory, then this command will destroy the previous one (in memory) and begin a new envelope. @@ -218,14 +217,14 @@ The `add_qedge` command adds an additional QEdge to the QueryGraph in the Messag ### expand() This command will expand (aka, answer/fill) your query graph in an edge-by-edge fashion, intelligently selecting which KPs to use for each edge. It selects KPs from the SmartAPI Registry based on the meta information provided by their TRAPI APIs (when available), whether they have an endpoint running a matching TRAPI version, and whether they have an endpoint with matching maturity. For each QEdge, it queries the selected KPs in parallel; it will timeout for a particular KP if it decides it's taking too long to respond. You may also optionally specify a particular KP to use via the 'kp' parameter (described below). -Current candidate KPs include (for TRAPI 1.3, maturity 'development'): -infores:arax-drug-treats-disease, infores:arax-normalized-google-distance, infores:automat-biolink, infores:automat-ctd, infores:automat-drug-central, infores:automat-gtex, infores:automat-gtopdb, infores:automat-gwas-catalog, infores:automat-hetio, infores:automat-hgnc, infores:automat-hmdb, infores:automat-human-goa, infores:automat-icees-kg, infores:automat-intact, infores:automat-ontology-hierarchy, infores:automat-panther, infores:automat-pharos, infores:automat-robokop, infores:automat-uberongraph, infores:automat-viral-proteome, infores:cam-kp, infores:cohd, infores:connections-hypothesis, infores:genetics-data-provider, infores:molepro, infores:rtx-kg2, infores:service-provider-trapi, infores:spoke, infores:sri-reference-kg, infores:text-mining-provider-cooccurrence. +Current candidate KPs include (for TRAPI 1.4, maturity 'development'): +infores:arax-drug-treats-disease, infores:arax-normalized-google-distance, infores:automat-gwas-catalog, infores:automat-hgnc, infores:automat-icees-kg, infores:automat-panther, infores:automat-sri-reference-kg, infores:cohd, infores:connections-hypothesis, infores:cqs, infores:genetics-data-provider, infores:knowledge-collaboratory, infores:molepro, infores:openpredict, infores:rtx-kg2, infores:service-provider-trapi, infores:spoke, infores:text-mining-provider-cooccurrence. (Note that this list of KPs may change unexpectedly based on the SmartAPI registry.) **Notes specific to usage of ARAX's internal KPs:** 1. NGD: The 'infores:arax-normalized-google-distance' KP uses ARAX's in-house normalized google distance (NGD) database to expand a query graph; it returns edges between nodes with an NGD value below a certain threshold. This threshold is currently hardcoded as 0.5, though this will be made configurable/smarter in the future. -2. DTD: The 'infores:arax-drug-treats-disease' KP uses ARAX's in-house drug-treats-disease (DTD) database (built from GraphSage model) to expand a query graph; it returns edges between nodes with a DTD probability above a certain threshold. The default threshold is currently set to 0.8. If you set this threshold below 0.8, you should also set DTD_slow_mode=True otherwise a warninig will occur. This is because the current DTD database only stores the pre-calcualted DTD probability above or equal to 0.8. Therefore, if an user set threshold below 0.8, it will automatically switch to call DTD model to do a real-time calculation and this will be quite time-consuming. In addition, if you call DTD database, your query node type would be checked. In other words, the query node has to have a sysnonym which is drug or disease. If you don't want to check node type, set DTD_slow_mode=true to call DTD model to do a real-time calculation. + #### parameters: @@ -295,62 +294,48 @@ infores:arax-drug-treats-disease, infores:arax-normalized-google-distance, infor - `true` and `false` are examples of valid inputs. -* ##### DTD_threshold - - - Applicable only when the 'infores:arax-drug-treats-disease' KP is used. Defines what cut-off/threshold to use for expanding the DTD virtual edges. - - - Acceptable input types: float. - - - This is not a required parameter and may be omitted. - - - `0.8` and `0.5` are examples of valid inputs. - - - The values for this parameter can range from a minimum value of 0 to a maximum value of 1. - - - If not specified the default input will be 0.8. +## ARAX_overlay +### overlay(action=compute_jaccard) -* ##### DTD_slow_mode +`compute_jaccard` creates virtual edges and adds an edge attribute (with the property name `jaccard_index`) containing the following information: +The jaccard similarity measures how many `intermediate_node_key`'s are shared in common between each `start_node_key` and `object_node_key`. +This is used for purposes such as "find me all drugs (`start_node_key`) that have many proteins (`intermediate_node_key`) in common with this disease (`end_node_key`)." +This can be used for downstream filtering to concentrate on relevant bioentities. - - Applicable only when the 'infores:arax-drug-treats-disease' KP is used. Specifies whether to call DTD model rather than DTD database to do a real-time calculation for DTD probability. +This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). + - - Acceptable input types: boolean. +#### parameters: - - This is not a required parameter and may be omitted. +* ##### start_node_key - - `true` and `false` are examples of valid inputs. + - A curie id specifying the starting node - - `true`, `false`, `True`, `False`, `t`, `f`, `T`, and `F` are all possible valid inputs. + - Acceptable input types: string. - - If not specified the default input will be false. + - This is a required parameter and must be included. -## ARAX_overlay -### overlay(action=compute_ngd) + - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. -`compute_ngd` computes a metric (called the normalized Google distance) based on edge soure/object node co-occurrence in abstracts of all PubMed articles. -This information is then included as an edge attribute with the name `normalized_google_distance`. -You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode id's. If the later, virtual edges are added with the type specified by `virtual_relation_label`. +* ##### intermediate_node_key -Use cases include: + - A curie id specifying the intermediate node -* focusing in on edges that are well represented in the literature -* focusing in on edges that are under-represented in the literature + - Acceptable input types: string. -This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). - + - This is a required parameter and must be included. -#### parameters: + - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. -* ##### default_value +* ##### end_node_key - - The default value of the normalized Google distance (if its value cannot be determined) + - A curie id specifying the ending node - Acceptable input types: string. - - This is not a required parameter and may be omitted. - - - `0` and `inf` are examples of valid inputs. + - This is a required parameter and must be included. - - If not specified the default input will be inf. + - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. * ##### virtual_relation_label @@ -358,40 +343,49 @@ This can be applied to an arbitrary knowledge graph as possible edge types are c - Acceptable input types: string. - - This is not a required parameter and may be omitted. + - This is a required parameter and must be included. - - `N1` and `J2` are examples of valid inputs. + - `N1`, `J2`, and `FET` are examples of valid inputs. -* ##### subject_qnode_key +### overlay(action=overlay_clinical_info) - - A specific subject query node id (optional, otherwise applied to all edges, must have a virtual_relation_label to use this parameter) +`overlay_clinical_info` overlay edges with information obtained from the knowledge provider (KP) Columbia Open Health Data (COHD). +This KP has a number of different functionalities, such as `paired_concept_frequency`, `observed_expected_ratio`, etc. which are mutually exclusive DSL parameters. +All information is derived from a 5 year hierarchical dataset: Counts for each concept include patients from descendant concepts. +This includes clinical data from 2013-2017 and includes 1,731,858 different patients. +This information is then included as an edge attribute. +You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode id's. If the later, virtual edges are added with the relation specified by `virtual_relation_label`. +These virtual edges have the following types: - - Acceptable input types: string. +* `paired_concept_frequency` has the virtual edge type `has_paired_concept_frequency_with` +* `observed_expected_ratio` has the virtual edge type `has_observed_expected_ratio_with` +* `chi_square` has the virtual edge type `has_chi_square_with` - - This is not a required parameter and may be omitted. +Note that this DSL command has quite a bit of functionality, so a brief description of the DSL parameters is given here: - - `n00` and `n01` are examples of valid inputs. +* `paired_concept_frequency`: If set to `true`, retrieves observed clinical frequencies of a pair of concepts indicated by edge subject and object nodes and adds these values as edge attributes. +* `observed_expected_ratio`: If set to `true`, returns the natural logarithm of the ratio between the observed count and expected count of edge subject and object nodes. Expected count is calculated from the single concept frequencies and assuming independence between the concepts. This information is added as an edge attribute. +* `chi_square`: If set to `true`, returns the chi-square statistic and p-value between pairs of concepts indicated by edge subject/object nodes and adds these values as edge attributes. The expected frequencies for the chi-square analysis are calculated based on the single concept frequencies and assuming independence between concepts. P-value is calculated with 1 DOF. +* `virtual_edge_type`: Overlays the requested information on virtual edges (ones that don't exist in the query graph). -* ##### object_qnode_key +This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). + - - A specific object query node id (optional, otherwise applied to all edges, must have a virtual_relation_label to use this parameter) +**NOTE:** The parameters `paired_concept_frequency`, `observed_expected_ratio`, and `chi_square` are mutually exclusive and thus will cause an error when more than one is included. - - Acceptable input types: string. +#### parameters: - - This is not a required parameter and may be omitted. +* ##### COHD_method - - `n00` and `n01` are examples of valid inputs. + - Which measure from COHD should be considered. -### overlay(action=overlay_exposures_data) + - Acceptable input types: string. -`overlay_exposures_data` overlays edges with p-values obtained from the ICEES+ (Integrated Clinical and Environmental Exposures Service) knowledge provider. -This information is included in edge attributes with the name `icees_p-value`. -You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode IDs. If the latter, the data is added in 'virtual' edges with the type `has_icees_p-value_with`. + - This is not a required parameter and may be omitted. -This can be applied to an arbitrary knowledge graph (i.e. not just those created/recognized by Expander Agent). - + - `paired_concept_frequency`, `observed_expected_ratio`, and `chi_square` are all possible valid inputs. -#### parameters: + - If not specified the default input will be paired_concept_frequency. * ##### virtual_relation_label @@ -524,75 +518,33 @@ _, pvalue = stats.fisher_exact([[a, b], [c, d]]) - If not specified the default input will be None. -### overlay(action=compute_jaccard) +### overlay(action=compute_ngd) -`compute_jaccard` creates virtual edges and adds an edge attribute (with the property name `jaccard_index`) containing the following information: -The jaccard similarity measures how many `intermediate_node_key`'s are shared in common between each `start_node_key` and `object_node_key`. -This is used for purposes such as "find me all drugs (`start_node_key`) that have many proteins (`intermediate_node_key`) in common with this disease (`end_node_key`)." -This can be used for downstream filtering to concentrate on relevant bioentities. +`compute_ngd` computes a metric (called the normalized Google distance) based on edge soure/object node co-occurrence in abstracts of all PubMed articles. +This information is then included as an edge attribute with the name `normalized_google_distance`. +You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode id's. If the later, virtual edges are added with the type specified by `virtual_relation_label`. + +Use cases include: + +* focusing in on edges that are well represented in the literature +* focusing in on edges that are under-represented in the literature This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). #### parameters: -* ##### start_node_key - - - A curie id specifying the starting node - - - Acceptable input types: string. - - - This is a required parameter and must be included. - - - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. - -* ##### intermediate_node_key - - - A curie id specifying the intermediate node - - - Acceptable input types: string. - - - This is a required parameter and must be included. - - - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. - -* ##### end_node_key - - - A curie id specifying the ending node - - - Acceptable input types: string. - - - This is a required parameter and must be included. - - - `DOID:1872`, `CHEBI:7476`, and `UMLS:C1764836` are examples of valid inputs. - -* ##### virtual_relation_label +* ##### default_value - - An optional label to help identify the virtual edge in the relation field. + - The default value of the normalized Google distance (if its value cannot be determined) - Acceptable input types: string. - - This is a required parameter and must be included. - - - `N1`, `J2`, and `FET` are examples of valid inputs. - -### overlay(action=predict_drug_treats_disease) - -`predict_drug_treats_disease` utilizes a machine learning model (trained on KP ARAX/KG1) to assign a probability that a given drug/chemical_substance treats a disease/phenotypic feature. -For more information about how this model was trained and how it performs, please see [this publication](https://doi.org/10.1101/765305). -The drug-disease treatment prediction probability is included as an edge attribute (with the attribute name `probability_treats`). -You have the choice of applying this to all appropriate edges in the knowledge graph, or only between specified subject/object qnode id's (make sure one is a chemical_substance, and the other is a disease or phenotypic_feature). -If the later, virtual edges are added with the relation specified by `virtual_edge_type` and the type `probably_treats`. -Use cases include: - -* Overlay drug the probability of any drug in your knowledge graph treating any disease via `overlay(action=predict_drug_treats_disease)` -* For specific drugs and diseases/phenotypes in your graph, add the probability that the drug treats them with something like `overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1)` -* Subsequently remove low-probability treating drugs with `overlay(action=predict_drug_treats_disease)` followed by `filter_kg(action=remove_edges_by_attribute, edge_attribute=probability_treats, direction=below, threshold=.6, remove_connected_nodes=t, qnode_key=n02)` + - This is not a required parameter and may be omitted. -This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). - + - `0` and `inf` are examples of valid inputs. -#### parameters: + - If not specified the default input will be inf. * ##### virtual_relation_label @@ -624,72 +576,17 @@ This can be applied to an arbitrary knowledge graph as possible edge types are c - `n00` and `n01` are examples of valid inputs. -* ##### threshold - - - What cut-off/threshold to use for DTD probability (optional, the default is 0.8) - - - Acceptable input types: int or float or None. - - - This is not a required parameter and may be omitted. - - - `0.8`, `0.95`, and `0.5` are examples of valid inputs. - - - If not specified the default input will be 0.8. - -* ##### slow_mode - - - Whether to call DTD model directly rather than the precomputed DTD database to do a real-time calculation for DTD probability (default is False) - - - Acceptable input types: boolean. - - - This is not a required parameter and may be omitted. - - - `True` and `False` are examples of valid inputs. - - - `T`, `t`, `True`, `F`, `f`, and `False` are all possible valid inputs. - - - If not specified the default input will be false. - -### overlay(action=overlay_clinical_info) - -`overlay_clinical_info` overlay edges with information obtained from the knowledge provider (KP) Columbia Open Health Data (COHD). -This KP has a number of different functionalities, such as `paired_concept_frequency`, `observed_expected_ratio`, etc. which are mutually exclusive DSL parameters. -All information is derived from a 5 year hierarchical dataset: Counts for each concept include patients from descendant concepts. -This includes clinical data from 2013-2017 and includes 1,731,858 different patients. -This information is then included as an edge attribute. -You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode id's. If the later, virtual edges are added with the relation specified by `virtual_relation_label`. -These virtual edges have the following types: - -* `paired_concept_frequency` has the virtual edge type `has_paired_concept_frequency_with` -* `observed_expected_ratio` has the virtual edge type `has_observed_expected_ratio_with` -* `chi_square` has the virtual edge type `has_chi_square_with` - -Note that this DSL command has quite a bit of functionality, so a brief description of the DSL parameters is given here: +### overlay(action=overlay_exposures_data) -* `paired_concept_frequency`: If set to `true`, retrieves observed clinical frequencies of a pair of concepts indicated by edge subject and object nodes and adds these values as edge attributes. -* `observed_expected_ratio`: If set to `true`, returns the natural logarithm of the ratio between the observed count and expected count of edge subject and object nodes. Expected count is calculated from the single concept frequencies and assuming independence between the concepts. This information is added as an edge attribute. -* `chi_square`: If set to `true`, returns the chi-square statistic and p-value between pairs of concepts indicated by edge subject/object nodes and adds these values as edge attributes. The expected frequencies for the chi-square analysis are calculated based on the single concept frequencies and assuming independence between concepts. P-value is calculated with 1 DOF. -* `virtual_edge_type`: Overlays the requested information on virtual edges (ones that don't exist in the query graph). +`overlay_exposures_data` overlays edges with p-values obtained from the ICEES+ (Integrated Clinical and Environmental Exposures Service) knowledge provider. +This information is included in edge attributes with the name `icees_p-value`. +You have the choice of applying this to all edges in the knowledge graph, or only between specified subject/object qnode IDs. If the latter, the data is added in 'virtual' edges with the type `has_icees_p-value_with`. -This can be applied to an arbitrary knowledge graph as possible edge types are computed dynamically (i.e. not just those created/recognized by the ARA Expander team). +This can be applied to an arbitrary knowledge graph (i.e. not just those created/recognized by Expander Agent). -**NOTE:** The parameters `paired_concept_frequency`, `observed_expected_ratio`, and `chi_square` are mutually exclusive and thus will cause an error when more than one is included. - #### parameters: -* ##### COHD_method - - - Which measure from COHD should be considered. - - - Acceptable input types: string. - - - This is not a required parameter and may be omitted. - - - `paired_concept_frequency`, `observed_expected_ratio`, and `chi_square` are all possible valid inputs. - - - If not specified the default input will be paired_concept_frequency. - * ##### virtual_relation_label - An optional label to help identify the virtual edge in the relation field. @@ -1817,7 +1714,7 @@ This cannot be applied to non disease/phenotypic feature nodes (nodes that do no * ##### n_drugs - - The number of drug nodes to return. If not provided defaults to 10. Considering the response speed, the maximum number of drugs returned is only allowed to be 25. + - The number of drug nodes to return. If not provided defaults to 25. Considering the response speed, the maximum number of drugs returned is only allowed to be 25. - Acceptable input types: integer. @@ -1825,11 +1722,11 @@ This cannot be applied to non disease/phenotypic feature nodes (nodes that do no - `5`, `15`, and `25` are examples of valid inputs. - - If not specified the default input will be 10. + - If not specified the default input will be 25. * ##### n_paths - - The number of paths connecting to each returned node. If not provided defaults to 10. Considering the response speed, the maximum number of paths (if available) returned is only allowed to be 25. + - The number of paths connecting to each returned node. If not provided defaults to 25. Considering the response speed, the maximum number of paths (if available) returned is only allowed to be 25. - Acceptable input types: integer. @@ -1837,7 +1734,7 @@ This cannot be applied to non disease/phenotypic feature nodes (nodes that do no - `5`, `15`, and `25` are examples of valid inputs. - - If not specified the default input will be 10. + - If not specified the default input will be 25. ### infer(action=chemical_gene_regulation_graph_expansion) diff --git a/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json b/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json index c521bba5b..60f3e1abd 100644 --- a/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json +++ b/code/ARAX/KnowledgeSources/RTX_KG2c_test_triples.json @@ -11,20 +11,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "subject_id": "HP:0000010", + "object_id": "PUBCHEM.COMPOUND:588", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -42,11 +42,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Protein", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211595", - "object_id": "PUBCHEM.COMPOUND:15979", + "subject_id": "CHEMBL.TARGET:CHEMBL1075091", + "object_id": "CHEMBL.COMPOUND:CHEMBL4650324", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -55,11 +55,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000936", - "object_id": "PUBCHEM.COMPOUND:42586", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201506", + "object_id": "PUBCHEM.COMPOUND:44135672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -68,11 +68,11 @@ ] }, { - "subject_category": "biolink:GeneFamily", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907606", - "object_id": "CHEMBL.COMPOUND:CHEMBL4650280", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1200448", + "object_id": "PUBCHEM.COMPOUND:5957", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -81,24 +81,24 @@ ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "MESH:D004815", + "subject_id": "UMLS:C0001038", + "object_id": "PUBCHEM.COMPOUND:1045", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Drug", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1075232", - "object_id": "PUBCHEM.COMPOUND:25195495", + "subject_id": "RXNORM:1246101", + "object_id": "MESH:D000073893", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -107,11 +107,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "PUBCHEM.COMPOUND:101620072", + "subject_id": "ENSEMBL:ENSG00000211595", + "object_id": "PUBCHEM.COMPOUND:15979", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -120,102 +120,102 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "MESH:D000073893", + "subject_id": "MESH:D005312", + "object_id": "PUBCHEM.COMPOUND:1188", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Disease", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "PUBCHEM.COMPOUND:1045", + "subject_id": "DOID:0080747", + "object_id": "PUBCHEM.COMPOUND:962", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DOID:0080747", - "object_id": "PUBCHEM.COMPOUND:962", + "subject_id": "UMLS:C0002345", + "object_id": "MESH:D004815", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "PUBCHEM.COMPOUND:135398633", + "subject_id": "UMLS:C0000936", + "object_id": "PUBCHEM.COMPOUND:42586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005373", - "object_id": "PUBCHEM.COMPOUND:26879", + "subject_id": "UMLS:C0000934", + "object_id": "MESH:D000073893", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100", - "object_id": "PUBCHEM.COMPOUND:3108", + "subject_id": "HP:0000016", + "object_id": "PUBCHEM.COMPOUND:129211", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:Cell", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "KEGG.DRUG:D10748", - "object_id": "UMLS:C3900018", + "subject_id": "MESH:D011387", + "object_id": "PUBCHEM.COMPOUND:135398633", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211593", - "object_id": "UMLS:C0008015", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "PUBCHEM.COMPOUND:10131048", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -224,76 +224,76 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "MESH:C000521", + "subject_id": "UBERON:0000004", + "object_id": "PUBCHEM.COMPOUND:10237", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "MESH:D010957", + "subject_id": "MONDO:0000313", + "object_id": "PUBCHEM.COMPOUND:16137271", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1293305", - "object_id": "CHEMBL.COMPOUND:CHEMBL2109438", + "subject_id": "MESH:D000067128", + "object_id": "MESH:D004815", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "DOID:0080747", - "object_id": "MESH:D013256", + "subject_id": "NCBIGene:100", + "object_id": "PUBCHEM.COMPOUND:439693", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HP:0000010", - "object_id": "MESH:D004967", + "subject_id": "CHEMBL.TARGET:CHEMBL1907606", + "object_id": "CHEMBL.COMPOUND:CHEMBL4650280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HP:0000016", - "object_id": "UMLS:C0011777", + "subject_id": "UMLS:C0007165", + "object_id": "PUBCHEM.COMPOUND:1001", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -302,24 +302,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "MESH:C000605867", + "subject_id": "UMLS:C0000854", + "object_id": "PUBCHEM.COMPOUND:11333", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCIT:C152915", - "object_id": "MESH:C052758", + "subject_id": "UMLS:C0002085", + "object_id": "PUBCHEM.COMPOUND:101620072", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -328,11 +328,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "MESH:C031917", + "subject_id": "UMLS:C0033213", + "object_id": "PUBCHEM.COMPOUND:10954115", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -341,37 +341,37 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "MESH:D004583", + "subject_id": "UMLS:C0005938", + "object_id": "PUBCHEM.COMPOUND:10228", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "MESH:C022461", + "subject_id": "UMLS:C0005373", + "object_id": "PUBCHEM.COMPOUND:26879", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "DRUGBANK:DB14329", + "subject_id": "CHEBI:15033", + "object_id": "PUBCHEM.COMPOUND:219104", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -380,63 +380,63 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "LOINC:LA12870-4", - "object_id": "MESH:D003165", + "subject_id": "UMLS:C0002957", + "object_id": "PUBCHEM.COMPOUND:439302", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "MESH:C093516", + "subject_id": "MESH:D016753", + "object_id": "CHEMBL.COMPOUND:CHEMBL1222251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200477", - "object_id": "MESH:D014968", + "subject_id": "UMLS:C0038813", + "object_id": "PUBCHEM.COMPOUND:6199", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "MESH:D004602", + "subject_id": "UMLS:C0024923", + "object_id": "PUBCHEM.COMPOUND:3016", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MONDO:0001142", - "object_id": "UMLS:C0699930", + "subject_id": "UMLS:C0001884", + "object_id": "PUBCHEM.COMPOUND:100528", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -445,37 +445,37 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1615322", - "object_id": "CHEMBL.COMPOUND:CHEMBL4297246", + "subject_id": "PR:000006102", + "object_id": "PUBCHEM.COMPOUND:111095", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "UMLS:C1550678", + "subject_id": "MESH:D008925", + "object_id": "PUBCHEM.COMPOUND:444037", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024923", - "object_id": "UMLS:C0304712", + "subject_id": "CHEMBL.TARGET:CHEMBL3826841", + "object_id": "PUBCHEM.COMPOUND:118513932", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -484,50 +484,50 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "MESH:D000728", + "subject_id": "UMLS:C0001884", + "object_id": "PUBCHEM.COMPOUND:108156", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "MESH:D000110", + "subject_id": "CHEBI:61995", + "object_id": "CHEMBL.COMPOUND:CHEMBL1222251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "MESH:C499379", + "subject_id": "UMLS:C1167395", + "object_id": "MESH:D000073893", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Cell", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "MESH:C000589760", + "subject_id": "UMLS:C0001280", + "object_id": "PUBCHEM.COMPOUND:13710202", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -536,50 +536,37 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "MESH:C000611407", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "MESH:D000588", + "subject_id": "UMLS:C0001038", + "object_id": "MESH:D004815", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:Activity", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150598", - "object_id": "MESH:D004602", + "subject_id": "UMLS:C0015259", + "object_id": "PUBCHEM.COMPOUND:10917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:C018362", + "subject_id": "UMLS:C0031911", + "object_id": "MESH:C064769", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -588,102 +575,102 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Device", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10060", - "object_id": "PUBCHEM.COMPOUND:47528", + "subject_id": "UMLS:C0002671", + "object_id": "PUBCHEM.COMPOUND:4507", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:IndividualOrganism", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "PUBCHEM.COMPOUND:11333", + "subject_id": "UMLS:C0677040", + "object_id": "PUBCHEM.COMPOUND:1014", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0038813", - "object_id": "PUBCHEM.COMPOUND:6199", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201865", + "object_id": "CHEMBL.TARGET:CHEMBL2364176", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "PUBCHEM.COMPOUND:439302", + "subject_id": "CHEBI:28815", + "object_id": "CHEMBL.COMPOUND:CHEMBL4594565", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "LOINC:LP7067-4", - "object_id": "PUBCHEM.COMPOUND:135433360", + "subject_id": "UMLS:C0079686", + "object_id": "PUBCHEM.COMPOUND:162420557", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "HP:0000016", - "object_id": "PUBCHEM.COMPOUND:129211", + "subject_id": "PUBCHEM.COMPOUND:176", + "object_id": "PUBCHEM.COMPOUND:5943", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:OrganismAttribute", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024923", - "object_id": "PUBCHEM.COMPOUND:3016", + "subject_id": "UMLS:C0005910", + "object_id": "PUBCHEM.COMPOUND:6013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Food", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "PUBCHEM.COMPOUND:13710202", + "subject_id": "UMLS:C0006138", + "object_id": "PUBCHEM.COMPOUND:16137271", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -692,11 +679,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:NamedThing", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "MESH:D004815", + "subject_id": "MESH:D000090982", + "object_id": "PUBCHEM.COMPOUND:5281078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -705,11 +692,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200448", - "object_id": "PUBCHEM.COMPOUND:5957", + "subject_id": "CHEBI:60027", + "object_id": "CHEMBL.COMPOUND:CHEMBL783", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -718,37 +705,37 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "PUBCHEM.COMPOUND:10237", + "subject_id": "UMLS:C0000854", + "object_id": "MESH:D000588", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HP:0000010", - "object_id": "PUBCHEM.COMPOUND:588", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "MESH:C031917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:15033", - "object_id": "PUBCHEM.COMPOUND:219104", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201564", + "object_id": "UNII:07MXG07O12", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -757,24 +744,24 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "PUBCHEM.COMPOUND:1001", + "subject_id": "HP:0000010", + "object_id": "MESH:D004967", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3826841", - "object_id": "PUBCHEM.COMPOUND:118513932", + "subject_id": "UMLS:C0001884", + "object_id": "CHEMBL.COMPOUND:CHEMBL517712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -783,80 +770,76 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100", - "object_id": "PUBCHEM.COMPOUND:439693", + "subject_id": "UMLS:C0001884", + "object_id": "CHEMBL.COMPOUND:CHEMBL517712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "MESH:D004815", + "subject_id": "UMLS:C0001038", + "object_id": "MESH:D010957", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "PUBCHEM.COMPOUND:10228", + "subject_id": "CHEMBL.TARGET:CHEMBL1075319", + "object_id": "CHEMBL.COMPOUND:CHEMBL3707315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:Disease", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0000313", - "object_id": "PUBCHEM.COMPOUND:16137271", + "subject_id": "DOID:0080747", + "object_id": "MESH:D013256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "subject_id": "UMLS:C0000934", + "object_id": "MESH:C000521", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "MESH:C410027", + "subject_id": "ENSEMBL:ENSG00000211593", + "object_id": "UMLS:C0008015", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -865,11 +848,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "PUBCHEM.COMPOUND:10917", + "subject_id": "RXNORM:1246101", + "object_id": "MESH:C084795", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -878,24 +861,24 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Cell", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:108156", + "subject_id": "MESH:D011387", + "object_id": "MESH:D004259", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "PUBCHEM.COMPOUND:4507", + "subject_id": "MESH:D016753", + "object_id": "MESH:C000606896", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -904,37 +887,37 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006138", - "object_id": "PUBCHEM.COMPOUND:16137271", + "subject_id": "UMLS:C0002345", + "object_id": "MESH:D000110", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005910", - "object_id": "PUBCHEM.COMPOUND:6013", + "subject_id": "UBERON:0000004", + "object_id": "MESH:C093516", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:100528", + "subject_id": "UMLS:C0000934", + "object_id": "MESH:D000728", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -943,50 +926,50 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Cell", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "PUBCHEM.COMPOUND:14806", + "subject_id": "MESH:D011387", + "object_id": "UMLS:C1550678", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "PR:000006102", - "object_id": "PUBCHEM.COMPOUND:111095", + "subject_id": "MESH:D000067128", + "object_id": "MESH:C094340", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907593", - "object_id": "PUBCHEM.COMPOUND:11528435", + "subject_id": "MESH:D005312", + "object_id": "MESH:D001786", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "PUBCHEM.COMPOUND:10954115", + "subject_id": "UMLS:C0001038", + "object_id": "MESH:C038253", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -995,24 +978,24 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "MESH:D000073893", + "subject_id": "UMLS:C0024923", + "object_id": "UMLS:C0304712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "MESH:C064769", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1200477", + "object_id": "MESH:D014968", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1021,50 +1004,50 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "PUBCHEM.COMPOUND:1014", + "subject_id": "MESH:D000090982", + "object_id": "MESH:C048844", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108311", - "object_id": "PUBCHEM.COMPOUND:1023", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:C018362", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201431", - "object_id": "PUBCHEM.COMPOUND:44135672", + "subject_id": "CHEMBL.TARGET:CHEMBL3826826", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108278", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "PUBCHEM.COMPOUND:444037", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201466", + "object_id": "PR:000007204", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1074,36 +1057,36 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079686", - "object_id": "PUBCHEM.COMPOUND:162420557", + "subject_id": "UMLS:C0000084", + "object_id": "UMLS:C0005456", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:C588202", - "object_id": "PUBCHEM.COMPOUND:439302", + "subject_id": "UMLS:C0205254", + "object_id": "UMLS:C0002191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "CHEMBL.COMPOUND:CHEMBL783", + "subject_id": "CHEBI:31349", + "object_id": "UMLS:C0015525", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1112,11 +1095,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "PUBCHEM.COMPOUND:101689", + "subject_id": "HP:0000092", + "object_id": "UMLS:C0359156", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1125,11 +1108,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "MESH:D004259", + "subject_id": "NCIT:C123912", + "object_id": "PR:000003065", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1138,24 +1121,24 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "MESH:C038253", + "subject_id": "UBERON:0000004", + "object_id": "UMLS:C0001924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEMBL.COMPOUND:CHEMBL517712", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "PUBCHEM.COMPOUND:46783232", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1164,24 +1147,24 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "CHEMBL.COMPOUND:CHEMBL517712", + "subject_id": "CHEMBL.TARGET:CHEMBL1075126", + "object_id": "PUBCHEM.COMPOUND:134693700", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0001924", + "subject_id": "CHEBI:3743", + "object_id": "PUBCHEM.COMPOUND:9916", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1190,11 +1173,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCIT:C2471", - "object_id": "PR:000003035", + "subject_id": "MESH:C002502", + "object_id": "MESH:D002186", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1203,11 +1186,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Protein", + "subject_category": "biolink:Drug", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000084", - "object_id": "UMLS:C0005456", + "subject_id": "RXNORM:1246101", + "object_id": "PUBCHEM.COMPOUND:54729367", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1216,115 +1199,115 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205254", - "object_id": "UMLS:C0002191", + "subject_id": "UBERON:0000044", + "object_id": "PUBCHEM.COMPOUND:134715697", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:31349", - "object_id": "UMLS:C0015525", + "subject_id": "UMLS:C0000934", + "object_id": "PUBCHEM.COMPOUND:16667503", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Protein", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "UMLS:C0001924", + "subject_id": "ENSEMBL:ENSG00000211625", + "object_id": "PUBCHEM.COMPOUND:5310940", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:Cell", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0000505", - "object_id": "UMLS:C0025646", + "subject_id": "UMLS:C0001280", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", + "subject_category": "biolink:Disease", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907593", - "object_id": "PUBCHEM.COMPOUND:13221", + "subject_id": "DOID:3044", + "object_id": "PUBCHEM.COMPOUND:5311489", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001166", - "object_id": "MESH:D002186", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2109626", + "object_id": "PUBCHEM.COMPOUND:44144477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "PUBCHEM.COMPOUND:10339178", + "subject_id": "UMLS:C0001166", + "object_id": "MESH:D002186", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211625", - "object_id": "PUBCHEM.COMPOUND:5310940", + "subject_id": "MESH:D000067128", + "object_id": "PUBCHEM.COMPOUND:134715697", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001399", - "object_id": "PUBCHEM.COMPOUND:136146407", + "subject_id": "CHEMBL.TARGET:CHEMBL2366047", + "object_id": "PUBCHEM.COMPOUND:11691495", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1333,15 +1316,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C0002345", + "object_id": "PUBCHEM.COMPOUND:5460033", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -1354,16 +1337,16 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:3743", - "object_id": "PUBCHEM.COMPOUND:9916", + "subject_id": "UMLS:C0002085", + "object_id": "PUBCHEM.COMPOUND:10339178", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1372,11 +1355,11 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "PUBCHEM.COMPOUND:5831", + "subject_id": "UMLS:C0001399", + "object_id": "PUBCHEM.COMPOUND:136146407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1385,28 +1368,28 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1667702", - "object_id": "PUBCHEM.COMPOUND:11685945", + "subject_id": "UMLS:C0001801", + "object_id": "PUBCHEM.COMPOUND:16684434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UBERON:0000004", + "object_id": "PUBCHEM.COMPOUND:134156256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -1419,81 +1402,94 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Cell", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "PUBCHEM.COMPOUND:134715697", + "subject_id": "MESH:D011387", + "object_id": "UMLS:C0023820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "DOID:0080747", + "object_id": "UMLS:C0243043", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", "subject_id": "UMLS:C0000934", - "object_id": "PUBCHEM.COMPOUND:16667503", + "object_id": "UMLS:C0001291", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001801", - "object_id": "PUBCHEM.COMPOUND:16684434", + "subject_id": "UMLS:C0002957", + "object_id": "UMLS:C0026455", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "DOID:3044", - "object_id": "PUBCHEM.COMPOUND:5311489", + "subject_id": "ENSEMBL:ENSG00000211595", + "object_id": "UMLS:C0389071", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "PUBCHEM.COMPOUND:10339178", + "subject_id": "UMLS:C0002957", + "object_id": "MESH:D004602", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364186", - "object_id": "PUBCHEM.COMPOUND:71587550", + "subject_id": "UMLS:C0009928", + "object_id": "PUBCHEM.COMPOUND:16132283", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1502,54 +1498,54 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "LOINC:LP7067-4", - "object_id": "PUBCHEM.COMPOUND:23663392", + "subject_id": "NCBIGene:10381", + "object_id": "DrugCentral:4990", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "PUBCHEM.COMPOUND:134156256", + "subject_id": "CHEMBL.TARGET:CHEMBL1907589", + "object_id": "CHEMBL.COMPOUND:CHEMBL3707250", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "PUBCHEM.COMPOUND:16132283", + "subject_id": "UMLS:C0033213", + "object_id": "PUBCHEM.COMPOUND:1061", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:CellularComponent", - "object_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "MESH:C010615", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C0003591", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -1557,8 +1553,8 @@ "subject_category": "biolink:GeneFamily", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2093864", - "object_id": "PUBCHEM.COMPOUND:11236066", + "subject_id": "CHEMBL.TARGET:CHEMBL1907610", + "object_id": "CHEMBL.COMPOUND:CHEMBL1723", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1568,10 +1564,10 @@ }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "HP:0000217", - "object_id": "PUBCHEM.COMPOUND:23667548", + "subject_id": "HP:0000016", + "object_id": "UMLS:C0011777", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1580,63 +1576,63 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "PUBCHEM.COMPOUND:175988", + "subject_id": "HP:0000020", + "object_id": "UMLS:C0019018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005479", - "object_id": "PUBCHEM.COMPOUND:175586", + "subject_id": "UMLS:C0001166", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "MESH:D014357", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0021666", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0184625", - "object_id": "PUBCHEM.COMPOUND:23667548", + "subject_id": "MESH:D005312", + "object_id": "UMLS:C0001924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "PUBCHEM.COMPOUND:101834999", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C1335439", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1645,24 +1641,24 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Cell", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024923", - "object_id": "PUBCHEM.COMPOUND:24083", + "subject_id": "UMLS:C0001280", + "object_id": "UMLS:C0029297", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0000988", - "object_id": "PUBCHEM.COMPOUND:9794626", + "subject_id": "UMLS:C0001038", + "object_id": "UMLS:C0002318", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1671,11 +1667,11 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007742", - "object_id": "PUBCHEM.COMPOUND:23994", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", + "object_id": "CHEMBL.TARGET:CHEMBL240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1684,37 +1680,37 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1017", - "object_id": "DRUGBANK:DB02950", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0001347", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Disease", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:117159", - "object_id": "PUBCHEM.COMPOUND:5727", + "subject_id": "MONDO:0001075", + "object_id": "UMLS:C0920330", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0003289", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0003009", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1723,24 +1719,24 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Drug", + "subject_category": "biolink:Activity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0001640", + "subject_id": "UMLS:C0085555", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "GO:0004647", - "object_id": "UMLS:C0025646", + "subject_id": "NCBIGene:100048905", + "object_id": "UMLS:C3539881", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1749,51 +1745,51 @@ ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010366", - "object_id": "PUBCHEM.COMPOUND:5460033", + "subject_id": "HP:0000217", + "object_id": "PUBCHEM.COMPOUND:23667548", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "PUBCHEM.COMPOUND:176", + "subject_id": "UMLS:C0005839", + "object_id": "PUBCHEM.COMPOUND:175988", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Device", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "PUBCHEM.COMPOUND:2723872", + "subject_id": "UMLS:C0005479", + "object_id": "PUBCHEM.COMPOUND:175586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Disease", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "MESH:D014357", - "qualifiers": [ + "subject_id": "MONDO:0000988", + "object_id": "PUBCHEM.COMPOUND:9794626", + "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity" @@ -1801,24 +1797,24 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Activity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001801", + "subject_id": "UMLS:C0237820", "object_id": "MESH:D014357", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1907593", - "object_id": "CHEMBL.COMPOUND:CHEMBL3707249", + "subject_id": "UMLS:C0184625", + "object_id": "PUBCHEM.COMPOUND:23667548", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1827,11 +1823,11 @@ ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1152266", - "object_id": "PUBCHEM.COMPOUND:34755", + "subject_id": "UMLS:C0001390", + "object_id": "PUBCHEM.COMPOUND:16684434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1840,37 +1836,37 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "PUBCHEM.COMPOUND:10954115", + "subject_id": "UMLS:C0024923", + "object_id": "PUBCHEM.COMPOUND:24083", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:PhysicalEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UniProtKB:K9N638", - "object_id": "PUBCHEM.COMPOUND:54752934", + "subject_id": "UMLS:C0007742", + "object_id": "PUBCHEM.COMPOUND:23994", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "PUBCHEM.COMPOUND:11155873", + "subject_id": "UMLS:C0019868", + "object_id": "PUBCHEM.COMPOUND:14806", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1879,37 +1875,37 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "PUBCHEM.COMPOUND:133128", + "subject_id": "NCBIGene:117159", + "object_id": "PUBCHEM.COMPOUND:5727", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "PUBCHEM.COMPOUND:10112", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0001640", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "PUBCHEM.COMPOUND:135902", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0001046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1918,63 +1914,63 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0007072", + "subject_id": "NCBIGene:116443", + "object_id": "PUBCHEM.COMPOUND:3152", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:NamedThing", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "MESH:D002186", + "subject_id": "MESH:D000519", + "object_id": "PUBCHEM.COMPOUND:6097028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "CHEMBL.COMPOUND:CHEMBL517712", + "subject_id": "UMLS:C0001801", + "object_id": "MESH:D014357", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Gene", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "CHEMBL.COMPOUND:CHEMBL517712", + "subject_id": "NCBIGene:1191", + "object_id": "CHEMBL.COMPOUND:CHEMBL2108309", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "CHEMBL.COMPOUND:CHEMBL517712", + "subject_id": "UMLS:C1152266", + "object_id": "PUBCHEM.COMPOUND:34755", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -1983,50 +1979,50 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "MESH:D004967", + "subject_id": "NCIT:C49019", + "object_id": "PUBCHEM.COMPOUND:2723872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:Cell", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0000020", - "object_id": "UMLS:C0019018", + "subject_id": "UMLS:C0001280", + "object_id": "UMLS:C0007072", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Procedure", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0001347", + "subject_id": "UMLS:C0001884", + "object_id": "MESH:D002186", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100048905", - "object_id": "UMLS:C3539881", + "subject_id": "MESH:D016753", + "object_id": "PUBCHEM.COMPOUND:10089466", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2035,24 +2031,24 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D011387", - "object_id": "UMLS:C0023820", + "subject_id": "UMLS:C1511997", + "object_id": "PUBCHEM.COMPOUND:133128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0021666", + "subject_id": "CHEBI:61995", + "object_id": "PUBCHEM.COMPOUND:135902", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2061,37 +2057,37 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Protein", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085555", - "object_id": "UMLS:C0061928", + "subject_id": "UMLS:C0005938", + "object_id": "PUBCHEM.COMPOUND:10112", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Disease", - "object_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "DOID:0080747", - "object_id": "UMLS:C0243043", + "subject_id": "MONDO:0001142", + "object_id": "UMLS:C0699930", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Protein", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C1335439", + "subject_id": "UMLS:C0007165", + "object_id": "CHEMBL.COMPOUND:CHEMBL517712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2100,11 +2096,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Protein", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211595", - "object_id": "UMLS:C0389071", + "subject_id": "CHEBI:61995", + "object_id": "DRUGBANK:DB14329", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2113,76 +2109,76 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0001291", + "subject_id": "UMLS:C0005839", + "object_id": "MESH:C022461", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Behavior", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "LOINC:LP7067-4", - "object_id": "UMLS:C0002520", + "subject_id": "UMLS:C0009928", + "object_id": "CHEMBL.COMPOUND:CHEMBL517712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0001347", + "subject_id": "UMLS:C0005938", + "object_id": "MESH:C000611407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Protein", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001166", - "object_id": "UMLS:C0061928", + "subject_id": "NCIT:C49019", + "object_id": "CHEMBL.COMPOUND:CHEMBL517712", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Protein", + "subject_category": "biolink:Activity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0001075", - "object_id": "UMLS:C0920330", + "subject_id": "UMLS:C0150598", + "object_id": "MESH:D004602", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Activity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", - "object_id": "CHEMBL.TARGET:CHEMBL240", + "subject_id": "UMLS:C0015259", + "object_id": "MESH:D004967", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2191,41 +2187,28 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "UMLS:C0026455", + "subject_id": "UMLS:C0000702", + "object_id": "MESH:D004583", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "UMLS:C0003009", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "UMLS:C0008546", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0001347", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -2238,7 +2221,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2251,20 +2234,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0018284", + "subject_id": "UMLS:C0001038", + "object_id": "UMLS:C0008546", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2277,7 +2260,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2294,12 +2277,25 @@ } ] }, + { + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0002345", + "object_id": "UMLS:C0003009", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, { "subject_category": "biolink:NamedThing", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0001271", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C5203674", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2316,7 +2312,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2333,12 +2329,25 @@ } ] }, + { + "subject_category": "biolink:Publication", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0599740", + "object_id": "PUBCHEM.COMPOUND:107838", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, { "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0007165", - "object_id": "PUBCHEM.COMPOUND:139036601", + "object_id": "PUBCHEM.COMPOUND:11953895", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2355,7 +2364,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularMixture", + "predicate": "biolink:causes", + "subject_id": "PUBCHEM.COMPOUND:23663392", + "object_id": "PUBCHEM.COMPOUND:91820602", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" } ] }, @@ -2373,24 +2395,24 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23663392", - "object_id": "PUBCHEM.COMPOUND:91820602", + "subject_id": "CHEBI:61995", + "object_id": "MESH:D000074262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0009279", - "object_id": "PUBCHEM.COMPOUND:134129842", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2399,58 +2421,54 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10381", - "object_id": "DrugCentral:4990", + "subject_id": "MONDO:0000088", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "MESH:D003472", + "subject_id": "UMLS:C0000934", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0001944", - "object_id": "CHEBI:61995", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "MESH:D003472", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", + "subject_id": "HP:0000019", "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2468,15 +2486,15 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "MESH:D000074262", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0003211", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2489,20 +2507,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0003211", + "subject_id": "MESH:D008055", + "object_id": "PUBCHEM.COMPOUND:5943", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2520,11 +2538,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "MESH:C120489", + "subject_id": "UMLS:C0033213", + "object_id": "MESH:D004573", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2533,11 +2551,11 @@ ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Food", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "MESH:C007104", + "subject_id": "UMLS:C0006494", + "object_id": "MESH:C120489", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2546,28 +2564,28 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Protein", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "MESH:D000949", + "subject_id": "UMLS:C0079686", + "object_id": "MESH:C496540", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079686", - "object_id": "MESH:C496540", + "subject_id": "MESH:D008925", + "object_id": "MESH:C508598", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -2585,24 +2603,24 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Drug", + "subject_category": "biolink:Publication", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "DOID:0080909", - "object_id": "UMLS:C0002842", + "subject_id": "UMLS:C0599740", + "object_id": "MESH:C020093", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:Gene", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "RXNORM:1246101", - "object_id": "UMLS:C0003402", + "subject_id": "ENSEMBL:ENSG00000211928", + "object_id": "UMLS:C0040616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2624,11 +2642,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001117", - "object_id": "UMLS:C0013227", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0003277", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2637,24 +2655,24 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2118", - "object_id": "PUBCHEM.COMPOUND:17336", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0003364", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Drug", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "HP:0000016", - "object_id": "UMLS:C0001641", + "subject_id": "RXNORM:1246101", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2663,24 +2681,24 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCIT:C33167", - "object_id": "UMLS:C1366005", + "subject_id": "HP:0000016", + "object_id": "UMLS:C0003385", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211928", - "object_id": "UMLS:C0040616", + "subject_id": "UMLS:C0001117", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2693,85 +2711,72 @@ "object_category": "biolink:Drug", "predicate": "biolink:causes", "subject_id": "HP:0000016", - "object_id": "UMLS:C0039052", + "object_id": "UMLS:C0001641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Disease", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "UMLS:C0003015", + "subject_id": "DOID:0080909", + "object_id": "UMLS:C0002842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Cell", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0003364", + "subject_id": "UMLS:C0001280", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0003402", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0002932", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2111348", - "object_id": "CHEMBL.COMPOUND:CHEMBL4650322", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1429", - "object_id": "PUBCHEM.COMPOUND:9852188", + "subject_id": "UBERON:0000004", + "object_id": "UMLS:C0003015", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0812399", - "object_id": "MESH:D014357", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2793,11 +2798,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Food", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "PUBCHEM.COMPOUND:23675242", + "subject_id": "UMLS:C0012171", + "object_id": "PUBCHEM.COMPOUND:56842208", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2806,11 +2811,11 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "PUBCHEM.COMPOUND:123812", + "subject_id": "UMLS:C0812399", + "object_id": "MESH:D014357", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2819,11 +2824,11 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:Procedure", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "PUBCHEM.COMPOUND:56842208", + "subject_id": "UMLS:C0001884", + "object_id": "PUBCHEM.COMPOUND:123812", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2832,11 +2837,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ChemicalMixture", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "PUBCHEM.COMPOUND:5311489", + "subject_id": "CHEBI:60027", + "object_id": "PUBCHEM.COMPOUND:23675242", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -2850,40 +2855,10 @@ "predicate": "biolink:causes", "subject_id": "UMLS:C1167395", "object_id": "MESH:C019722", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "UniProtKB:O91936", - "object_id": "PUBCHEM.COMPOUND:67683363", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "PUBCHEM.COMPOUND:10964", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" } ] }, @@ -2896,7 +2871,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -2935,33 +2910,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Protein", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "UMLS:C0242417", + "subject_id": "UMLS:C0033213", + "object_id": "MESH:C020650", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0000088", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0002671", + "object_id": "UMLS:C0242417", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -2979,76 +2954,76 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "PUBCHEM.COMPOUND:134156256", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C0002763", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0001038", + "object_id": "UMLS:C0003211", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000392", - "object_id": "MESH:D003472", + "subject_id": "UMLS:C1167395", + "object_id": "PUBCHEM.COMPOUND:134156256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "MESH:D014613", + "subject_id": "UMLS:C0000854", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Cell", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0001280", + "object_id": "MESH:D014613", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "UMLS:C0003009", + "subject_id": "UMLS:C0000392", + "object_id": "MESH:D003472", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3056,19 +3031,6 @@ } ] }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0029297", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, { "subject_category": "biolink:Behavior", "object_category": "biolink:MolecularMixture", @@ -3104,55 +3066,55 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0003209", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0001648", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Activity", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "UMLS:C0003211", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0001640", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Drug", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0013227", + "subject_id": "MESH:D000086942", + "object_id": "MESH:D000888", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Gene", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0001648", + "subject_id": "ENSEMBL:ENSG00000211638", + "object_id": "MESH:D005176", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3161,37 +3123,50 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Drug", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0001640", + "subject_id": "MESH:D002186", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "MESH:D000888", + "subject_id": "HP:0000360", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "MESH:D004573", + "subject_id": "MONDO:0000831", + "object_id": "MESH:D015942", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NamedThing", + "predicate": "biolink:causes", + "subject_id": "HP:0000989", + "object_id": "UMLS:C0966225", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3200,11 +3175,11 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0005778", + "object_id": "MESH:D005176", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3213,11 +3188,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211638", - "object_id": "UMLS:C0015528", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "MESH:D000519", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3226,11 +3201,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Cell", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205082", - "object_id": "UMLS:C0966225", + "subject_id": "UMLS:C0004112", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3265,10 +3240,10 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "HP:0000989", + "subject_id": "UMLS:C0205082", "object_id": "UMLS:C0966225", "qualifiers": [ { @@ -3281,12 +3256,12 @@ "subject_category": "biolink:Behavior", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023185", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0011109", + "object_id": "UMLS:C2719767", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -3294,25 +3269,25 @@ "subject_category": "biolink:Disease", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MONDO:0000831", - "object_id": "MESH:D015942", + "subject_id": "MONDO:0002050", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "HP:0000360", + "subject_id": "UMLS:C0001811", "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -3330,50 +3305,50 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Drug", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0003015", + "object_id": "UMLS:C0966225", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005778", - "object_id": "MESH:D015942", + "subject_id": "UMLS:C0003261", + "object_id": "MESH:D000090982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003015", - "object_id": "UMLS:C0966225", + "subject_id": "UBERON:0000007", + "object_id": "MESH:D003850", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MONDO:0002050", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C2930113", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3382,62 +3357,36 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0002268", + "subject_id": "UBERON:0000178", + "object_id": "MESH:D005176", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:1441", - "object_id": "DrugCentral:4986", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "PR:000001044", - "object_id": "CHEMBL.COMPOUND:CHEMBL3545292", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "MESH:D015942", + "subject_id": "UMLS:C0003314", + "object_id": "UMLS:C0038418", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003314", + "subject_id": "UMLS:C0001413", "object_id": "UMLS:C0038418", "qualifiers": [ { @@ -3447,11 +3396,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Gene", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "UMLS:C0699251", + "subject_id": "ENSEMBL:ENSG00000211594", + "object_id": "NCBIGene:5590", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3460,50 +3409,50 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Protein", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0000007", - "object_id": "MESH:D003850", + "subject_id": "UMLS:C0000084", + "object_id": "NCBIGene:5624", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0038418", + "subject_id": "UMLS:C0000934", + "object_id": "NCBIGene:100506930", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Disease", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0806909", - "object_id": "UMLS:C0015528", + "subject_id": "DOID:0080702", + "object_id": "NCBIGene:2737", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0038418", + "subject_id": "CHEBI:3743", + "object_id": "NCBIGene:1128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3512,63 +3461,63 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL3039537", - "object_id": "MESH:D002788", + "subject_id": "UMLS:C0000854", + "object_id": "NCBIGene:26155", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cohort", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0338666", - "object_id": "PUBCHEM.COMPOUND:446220", + "subject_id": "MESH:D005312", + "object_id": "NCBIGene:64423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Cell", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "PUBCHEM.COMPOUND:123925", + "subject_id": "UMLS:C0001280", + "object_id": "NCBIGene:10490", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:18296", - "object_id": "CHEMBL.COMPOUND:CHEMBL2107876", + "subject_id": "CHEBI:4875", + "object_id": "NCBIGene:7124", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4007", - "object_id": "UMLS:C4086010", + "subject_id": "UMLS:C0001038", + "object_id": "NCBIGene:100033819", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3577,24 +3526,24 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", - "predicate": "biolink:affects", - "subject_id": "NCBIGene:10280", - "object_id": "PUBCHEM.COMPOUND:656697", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001038", + "object_id": "NCBIGene:2033", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:affects", - "subject_id": "NCBIGene:10368", - "object_id": "PUBCHEM.COMPOUND:10236037", + "subject_category": "biolink:Disease", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "MONDO:0008000", + "object_id": "NCBIGene:114548", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3603,37 +3552,37 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0450138", - "object_id": "PUBCHEM.COMPOUND:94493", + "subject_id": "UMLS:C0002957", + "object_id": "NCBIGene:23013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003808", - "object_id": "CHEBI:61995", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", + "object_id": "NCBIGene:2078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "HP:0001824", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C1332838", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3642,50 +3591,50 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCBIGene:5553", - "object_id": "PUBCHEM.COMPOUND:9002", + "subject_id": "NCIT:C82271", + "object_id": "NCBIGene:2152", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularEntity", + "subject_category": "biolink:Cohort", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364181", - "object_id": "PUBCHEM.COMPOUND:9002", + "subject_id": "UMLS:C0338666", + "object_id": "PUBCHEM.COMPOUND:446220", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "MESH:C020650", + "subject_id": "MESH:D000086942", + "object_id": "MESH:C010615", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001873", - "object_id": "MESH:D017672", + "subject_id": "MESH:D008925", + "object_id": "PUBCHEM.COMPOUND:5311489", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3694,89 +3643,89 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:211", - "object_id": "PUBCHEM.COMPOUND:119058042", + "subject_id": "UMLS:C1511997", + "object_id": "PUBCHEM.COMPOUND:123925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0007578", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3039537", + "object_id": "MESH:D002788", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:IndividualOrganism", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "MESH:D000447", + "subject_id": "CHEBI:18296", + "object_id": "CHEMBL.COMPOUND:CHEMBL2107876", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0001924", + "subject_id": "CHEMBL.TARGET:CHEMBL4006", + "object_id": "UMLS:C4086010", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2153", - "object_id": "PUBCHEM.COMPOUND:65045", + "subject_id": "UMLS:C0450138", + "object_id": "PUBCHEM.COMPOUND:94493", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:117159", - "object_id": "PUBCHEM.COMPOUND:24424", + "subject_id": "UMLS:C0003808", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0282519", + "subject_id": "HP:0001824", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3785,24 +3734,24 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "LOINC:LA12870-4", - "object_id": "PUBCHEM.COMPOUND:2803", + "subject_id": "NCBIGene:211", + "object_id": "PUBCHEM.COMPOUND:119058042", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Protein", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1863515", - "object_id": "PUBCHEM.COMPOUND:126941", + "subject_id": "PR:000004191", + "object_id": "PUBCHEM.COMPOUND:6477182", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3811,50 +3760,63 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:SmallMolecule", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.TARGET:CHEMBL4296221", + "object_id": "PUBCHEM.COMPOUND:121492004", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" + } + ] + }, + { + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:C022699", + "subject_id": "CHEMBL.TARGET:CHEMBL4296221", + "object_id": "CHEMBL.COMPOUND:CHEMBL3989987", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Protein", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0003440", + "subject_id": "UMLS:C0033213", + "object_id": "PUBCHEM.COMPOUND:167265", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "UMLS:C0242565", + "subject_id": "CHEMBL.TARGET:CHEMBL2487", + "object_id": "CHEMBL.COMPOUND:CHEMBL4650301", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Publication", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010357", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0599740", + "object_id": "PUBCHEM.COMPOUND:5310940", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3863,24 +3825,37 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D002462", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C1511997", + "object_id": "MESH:D000449", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001644", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0002345", + "object_id": "UMLS:C0013227", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:Drug", + "predicate": "biolink:causes", + "subject_id": "MONDO:0000313", + "object_id": "UMLS:C0011947", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3890,10 +3865,10 @@ }, { "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100653366", - "object_id": "MESH:D022401", + "subject_id": "NCBIGene:100188776", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3902,89 +3877,89 @@ ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012899", - "object_id": "MESH:D010578", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0001644", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0001924", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Food", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0007578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "CHEBI:61995", + "subject_id": "UBERON:0001048", + "object_id": "MESH:D000728", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0020969", + "object_id": "MESH:C020485", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0001873", + "object_id": "MESH:D017672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBITaxon:11089", - "object_id": "MESH:D014612", + "subject_id": "CHEBI:60027", + "object_id": "MESH:D000888", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -3993,11 +3968,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0002050", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0030956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4006,24 +3981,24 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UBERON:0000323", - "object_id": "CHEBI:61995", + "subject_id": "MESH:D000067128", + "object_id": "MESH:D015942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Device", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "MESH:D005620", + "subject_id": "UMLS:C0043076", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4032,24 +4007,24 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", - "object_id": "MESH:D010578", + "subject_id": "NCBIGene:7896", + "object_id": "MESH:D003850", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "MESH:D007252", + "subject_id": "MESH:D005176", + "object_id": "UMLS:C0878494", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4058,24 +4033,24 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C1519885", - "object_id": "MESH:D014612", + "subject_id": "UMLS:C0017259", + "object_id": "MESH:D003850", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Food", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0277793", - "object_id": "MESH:D019496", + "subject_id": "UMLS:C0597423", + "object_id": "MESH:D015942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4084,49 +4059,49 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "MESH:D014612", + "subject_id": "NCBIGene:2520", + "object_id": "PUBCHEM.COMPOUND:4621", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "synthesis" } ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", + "subject_id": "UMLS:C0001038", "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "MESH:D013638", + "subject_id": "MESH:D016753", + "object_id": "MESH:D005620", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001640", "object_id": "MESH:D005620", "qualifiers": [ { @@ -4136,11 +4111,11 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "DRUGBANK:DB09446", + "subject_id": "MESH:D014357", + "object_id": "MESH:D007252", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4149,24 +4124,24 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Drug", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0001645", + "subject_id": "UBERON:0000044", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C1443643", + "subject_id": "NCBIGene:100653366", + "object_id": "MESH:D022401", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4176,10 +4151,10 @@ }, { "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Drug", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0013227", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4188,24 +4163,24 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C0003402", + "subject_id": "UMLS:C0012899", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0000313", - "object_id": "UMLS:C0011947", + "subject_id": "UMLS:C0000936", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4214,63 +4189,63 @@ ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020266", - "object_id": "UMLS:C0304604", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0003402", + "subject_id": "NCBIGene:5553", + "object_id": "PUBCHEM.COMPOUND:9002", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0001644", + "subject_id": "UMLS:C1167395", + "object_id": "MESH:D013638", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1257756", - "object_id": "PUBCHEM.COMPOUND:71306834", + "subject_id": "UBERON:0000323", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Disease", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "PUBCHEM.COMPOUND:16216920", + "subject_id": "MONDO:0002050", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4279,24 +4254,24 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0597357", + "subject_id": "UMLS:C0001801", + "object_id": "UMLS:C0732093", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Protein", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "UMLS:C0002520", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0001640", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4305,11 +4280,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Protein", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C0003442", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0003289", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4318,24 +4293,24 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "UMLS:C0010592", + "subject_id": "UMLS:C0001884", + "object_id": "UMLS:C0001645", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Activity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "UMLS:C0002520", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4344,11 +4319,11 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "MESH:D000888", + "subject_id": "UMLS:C0012171", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4357,128 +4332,128 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4296221", - "object_id": "CHEMBL.COMPOUND:CHEMBL3989987", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C1443643", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1191", - "object_id": "CHEMBL.COMPOUND:CHEMBL2108309", + "subject_id": "UBERON:0001048", + "object_id": "PUBCHEM.COMPOUND:10255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Device", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0001534", - "object_id": "UMLS:C0033086", + "subject_id": "NCBIGene:1131", + "object_id": "PUBCHEM.COMPOUND:86301316", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneFamily", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2094125", - "object_id": "UNII:3K045XR58X", + "subject_id": "MESH:D002462", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "PUBCHEM.COMPOUND:6099", + "subject_id": "UMLS:C0521974", + "object_id": "UMLS:C0023754", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Food", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL1781", - "object_id": "PUBCHEM.COMPOUND:9941008", + "subject_id": "UMLS:C0037732", + "object_id": "DRUGBANK:DB09446", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "MESH:D000449", + "subject_id": "UMLS:C0871470", + "object_id": "DRUGBANK:DB09446", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Drug", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "UMLS:C0013227", + "subject_id": "UniProtKB:P06434", + "object_id": "PUBCHEM.COMPOUND:71587550", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "expression" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1149593", - "object_id": "MESH:D014357", + "subject_id": "CHEMBL.TARGET:CHEMBL2364186", + "object_id": "PUBCHEM.COMPOUND:71587550", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UBERON:0001048", - "object_id": "MESH:D000728", + "subject_id": "UBERON:0002481", + "object_id": "PUBCHEM.COMPOUND:5284616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4487,24 +4462,24 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "MESH:C020485", + "subject_id": "UMLS:C0033213", + "object_id": "PUBCHEM.COMPOUND:23667548", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0030956", + "subject_id": "UMLS:C0001811", + "object_id": "NCBIGene:7157", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4513,50 +4488,50 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "MESH:D015942", + "subject_id": "HP:0001824", + "object_id": "NCBIGene:2796", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCBIGene:7896", - "object_id": "MESH:D003850", + "subject_id": "HP:0000016", + "object_id": "NCBIGene:166", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0043076", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0001884", + "object_id": "NCBIGene:196", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D015942", - "object_id": "UMLS:C1149593", + "subject_id": "MESH:D016753", + "object_id": "ENSEMBL:ENSG00000237197", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4565,11 +4540,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "NCBIGene:1026", + "subject_id": "UMLS:C0026377", + "object_id": "NCBIGene:9531", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4578,11 +4553,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:3743", - "object_id": "NCBIGene:1128", + "subject_id": "UMLS:C0002085", + "object_id": "NCBIGene:100124700", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4591,11 +4566,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Device", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "NCBIGene:100033819", + "subject_id": "UMLS:C0020266", + "object_id": "UMLS:C0304604", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4604,24 +4579,24 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Gene", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211594", - "object_id": "NCBIGene:5590", + "subject_id": "UMLS:C0003808", + "object_id": "UMLS:C2927841", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:Cell", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", - "object_id": "NCBIGene:2078", + "subject_id": "UMLS:C0003315", + "object_id": "UMLS:C1562036", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4630,11 +4605,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "PUBCHEM.COMPOUND:5284616", + "subject_id": "UMLS:C0003256", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4643,42 +4618,38 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL4296741", - "object_id": "PUBCHEM.COMPOUND:119058042", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:D014612", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "PUBCHEM.COMPOUND:136146407", + "subject_id": "UMLS:C0017654", + "object_id": "UMLS:C0904505", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1131", - "object_id": "PUBCHEM.COMPOUND:86301316", + "subject_id": "NCBIGene:1129", + "object_id": "PUBCHEM.COMPOUND:3450", "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, { "qualifier_type_id": "biolink:direction_qualifier", "qualifier_value": "decreased" @@ -4686,11 +4657,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:Protein", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB14329", - "object_id": "UMLS:C0037732", + "subject_id": "UMLS:C0002520", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4699,50 +4670,50 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Food", + "subject_category": "biolink:Gene", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "UMLS:C1518478", + "subject_id": "HGNC:12529", + "object_id": "UMLS:C0696946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Food", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0677040", + "object_id": "MESH:D000447", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Food", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0001076", - "object_id": "UMLS:C0012171", + "subject_id": "NCBIGene:117159", + "object_id": "PUBCHEM.COMPOUND:24424", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0428696", - "object_id": "UMLS:C0938430", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C3543842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4751,24 +4722,24 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0428696", - "object_id": "UMLS:C0938430", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1863515", + "object_id": "PUBCHEM.COMPOUND:126941", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Food", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003015", - "object_id": "UMLS:C0037570", + "subject_id": "UMLS:C0015919", + "object_id": "MESH:C022699", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4777,63 +4748,63 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Drug", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "UMLS:C0001640", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0003440", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Drug", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "UMLS:C0001645", + "subject_id": "MESH:D008925", + "object_id": "UMLS:C0242565", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Drug", + "subject_category": "biolink:Activity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001801", - "object_id": "UMLS:C0732093", + "subject_id": "UMLS:C0237820", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Drug", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0001645", + "subject_id": "UMLS:C0033213", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Drug", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0003402", + "subject_id": "UMLS:C0277793", + "object_id": "MESH:D019496", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4842,50 +4813,50 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0521974", - "object_id": "UMLS:C0023754", + "subject_id": "NCBITaxon:11089", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037732", - "object_id": "DRUGBANK:DB09446", + "subject_id": "UMLS:C0009393", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P06434", - "object_id": "PUBCHEM.COMPOUND:71587550", + "subject_id": "UMLS:C0020969", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205082", - "object_id": "PUBCHEM.COMPOUND:23706212", + "subject_id": "MESH:D000090982", + "object_id": "MESH:D014612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4894,63 +4865,63 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "CHEBI:82131", - "object_id": "NCBIGene:2153", + "subject_id": "UBERON:0001048", + "object_id": "UMLS:C0029960", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Gene", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "HP:0000073", - "object_id": "NCBIGene:25789", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0003009", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Gene", + "subject_category": "biolink:Activity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "DOID:0080702", - "object_id": "NCBIGene:2737", + "subject_id": "UMLS:C0015259", + "object_id": "UMLS:C0010592", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "NCBIGene:10490", + "subject_id": "MESH:D002097", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Gene", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000084", - "object_id": "NCBIGene:5624", + "subject_id": "UMLS:C0031911", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -4959,76 +4930,76 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "LOINC:LP7067-4", - "object_id": "NCBIGene:3684", + "subject_id": "CHEBI:60160", + "object_id": "UMLS:C0033684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Gene", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001884", - "object_id": "NCBIGene:196", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0002520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002957", - "object_id": "NCBIGene:31", + "subject_id": "MESH:C000594513", + "object_id": "UMLS:C0039194", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "NCBIGene:100506930", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0024880", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "NCBIGene:100124700", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UMLS:C0431085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "HP:0001824", - "object_id": "NCBIGene:2796", + "subject_id": "CHEMBL.COMPOUND:CHEMBL461101", + "object_id": "UMLS:C0005821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5037,154 +5008,141 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Drug", + "subject_category": "biolink:Protein", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C1562036", + "subject_id": "UMLS:C0001239", + "object_id": "UMLS:C0031307", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Drug", + "subject_category": "biolink:Gene", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003808", - "object_id": "UMLS:C2927841", + "subject_id": "ENSEMBL:ENSG00000211598", + "object_id": "UMLS:C0009013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017259", - "object_id": "MESH:D003850", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0014792", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Drug", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "UMLS:C0904505", + "subject_id": "UMLS:C0001637", + "object_id": "UMLS:C0596630", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:OrganismTaxon", - "predicate": "biolink:causes", - "subject_id": "UniProtKB:P09252", - "object_id": "UMLS:C1831828", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2703462", - "object_id": "UMLS:C1831828", + "subject_id": "NCIT:C120860", + "object_id": "UMLS:C0879593", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Protein", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0003009", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0004112", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL3820", - "object_id": "PUBCHEM.COMPOUND:25235800", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0004561", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Food", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2111348", - "object_id": "PUBCHEM.COMPOUND:11953895", + "subject_id": "UMLS:C0012171", + "object_id": "UMLS:C0014597", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:D002097", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "ENSEMBL:ENSG00000211625", + "object_id": "UMLS:C0007600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Device", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:60160", - "object_id": "UMLS:C0033684", + "subject_id": "UMLS:C0002671", + "object_id": "UMLS:C0014792", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0027882", + "subject_id": "HP:0011157", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5193,24 +5151,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", + "subject_id": "UMLS:C0002085", "object_id": "UMLS:C0004561", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211598", - "object_id": "UMLS:C0009013", + "subject_id": "MESH:D000519", + "object_id": "UMLS:C0225828", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5219,37 +5177,37 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UMLS:C0431085", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C0004112", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0597032", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0229656", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Drug", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0014597", + "subject_id": "UMLS:C0003921", + "object_id": "UMLS:C0506994", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5258,141 +5216,141 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001239", - "object_id": "UMLS:C0031307", + "subject_id": "NCBIGene:100188776", + "object_id": "UMLS:C1515077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL461101", - "object_id": "UMLS:C0005821", + "subject_id": "UMLS:C1157038", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0004112", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UBERON:0000178", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Cell", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211625", - "object_id": "UMLS:C0007600", + "subject_id": "ENSEMBL:ENSG00000211611", + "object_id": "UMLS:C1185714", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Cell", + "subject_category": "biolink:Protein", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001637", - "object_id": "UMLS:C0596630", + "subject_id": "UMLS:C0000254", + "object_id": "UBERON:0001759", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0004112", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0024109", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Cell", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0014597", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UBERON:0013757", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0004561", + "subject_id": "CHEMBL.TARGET:CHEMBL2364181", + "object_id": "PUBCHEM.COMPOUND:9002", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Cell", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "UMLS:C0014792", + "subject_id": "GO:0009279", + "object_id": "PUBCHEM.COMPOUND:134129842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Cell", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCIT:C54685", - "object_id": "UMLS:C1441017", + "subject_id": "UMLS:C1257756", + "object_id": "PUBCHEM.COMPOUND:71306834", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Cell", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UMLS:C0004561", + "subject_id": "UMLS:C0015919", + "object_id": "PUBCHEM.COMPOUND:16216920", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5401,11 +5359,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Cell", + "subject_category": "biolink:Publication", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001457", - "object_id": "UMLS:C0004112", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0001451", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5414,24 +5372,24 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0004561", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0030956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C1515077", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C0003442", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5440,271 +5398,271 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "UMLS:C0018956", + "subject_id": "CHEMBL.TARGET:CHEMBL2095182", + "object_id": "PUBCHEM.COMPOUND:11284169", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Cell", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373124", - "object_id": "UMLS:C0005821", + "subject_id": "UMLS:C0162764", + "object_id": "MESH:D006903", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GeneFamily", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "UBERON:0001759", + "subject_id": "CHEMBL.TARGET:CHEMBL2094111", + "object_id": "CHEMBL.COMPOUND:CHEMBL1201454", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UBERON:0001021", + "subject_id": "UMLS:C0031911", + "object_id": "MESH:D004967", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211611", - "object_id": "UMLS:C1185714", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0003286", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Cohort", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UBERON:0013757", + "subject_id": "UMLS:C0338666", + "object_id": "UMLS:C0242402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0024109", + "subject_id": "PUBCHEM.COMPOUND:453626", + "object_id": "UMLS:C0002198", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "MESH:D004967", + "subject_id": "CHEMBL.TARGET:CHEMBL1615322", + "object_id": "CHEMBL.COMPOUND:CHEMBL4297246", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:176", - "object_id": "PUBCHEM.COMPOUND:5943", + "subject_id": "CHEMBL.TARGET:CHEMBL4296741", + "object_id": "PUBCHEM.COMPOUND:119058042", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "abundance" } ] }, { - "subject_category": "biolink:Cohort", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0338666", - "object_id": "UMLS:C0242402", + "subject_id": "UMLS:C0031911", + "object_id": "PUBCHEM.COMPOUND:136146407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10246924", - "object_id": "NCBIGene:7416", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0019046", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Gene", + "subject_category": "biolink:Gene", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201538", - "object_id": "NCBIGene:3480", + "subject_id": "NCBIGene:3043", + "object_id": "PUBCHEM.COMPOUND:24529", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "molecular_modification" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Gene", + "subject_category": "biolink:Protein", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C1332838", + "subject_id": "UniProtKB:P69905", + "object_id": "PUBCHEM.COMPOUND:24529", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "molecular_modification" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2243", - "object_id": "CHEBI:8583", + "subject_id": "UMLS:C0009928", + "object_id": "UMLS:C0003921", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2152", - "object_id": "NCIT:C82271", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0003308", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201664", - "object_id": "NCBIGene:3480", + "subject_id": "UMLS:C0012872", + "object_id": "MESH:D017382", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Gene", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C82271", - "object_id": "NCBIGene:2152", + "subject_id": "UMLS:C0238711", + "object_id": "UMLS:C0242402", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Gene", + "subject_category": "biolink:Disease", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "NCBIGene:102723407", + "subject_id": "MONDO:0001534", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "NCBIGene:10286", + "subject_id": "UMLS:C0005839", + "object_id": "NCBIGene:10800", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "NCBIGene:10628", + "subject_id": "UBERON:0000004", + "object_id": "NCBIGene:102723407", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1152266", - "object_id": "NCBIGene:3398", + "subject_id": "NCBIGene:100049542", + "object_id": "UMLS:C1335144", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5713,63 +5671,63 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Cell", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "NCBIGene:2033", + "subject_id": "UMLS:C0002449", + "object_id": "NCBIGene:3576", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "NCBIGene:10133", + "subject_id": "UMLS:C0002345", + "object_id": "NCBIGene:10286", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000854", - "object_id": "NCBIGene:26155", + "subject_id": "MESH:D000067128", + "object_id": "NCBIGene:1058", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "NCBIGene:10800", + "subject_id": "MESH:D000090982", + "object_id": "NCBIGene:920", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100049542", - "object_id": "UMLS:C1335144", + "subject_id": "CHEBI:61995", + "object_id": "NCBIGene:10106", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5778,24 +5736,24 @@ ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Activity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "ENSEMBL:ENSG00000237197", + "subject_id": "UMLS:C0150598", + "object_id": "NCBIGene:1789", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "RXNORM:1246101", - "object_id": "NCBIGene:1649", + "subject_id": "UMLS:C1152266", + "object_id": "NCBIGene:3398", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5804,37 +5762,37 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "MESH:D017382", + "subject_id": "UMLS:C1115729", + "object_id": "NCBIGene:2357", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "MESH:C024211", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0005456", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162764", - "object_id": "MESH:D006903", + "subject_id": "MESH:C000521", + "object_id": "UMLS:C0043076", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5843,76 +5801,76 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "GO:0005219", - "object_id": "NCBIGene:1193", + "subject_id": "MESH:C015428", + "object_id": "UMLS:C0350056", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Gene", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "NCBIGene:7157", + "subject_id": "HP:0000505", + "object_id": "UMLS:C0165528", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "MESH:D015942", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2095222", + "object_id": "PR:000007581", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23663392", - "object_id": "CHEMBL.COMPOUND:CHEMBL1201636", + "subject_id": "NCBIGene:133", + "object_id": "CHEMBL.COMPOUND:CHEMBL4650434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000007", - "object_id": "UMLS:C0006556", + "subject_id": "ENSEMBL:ENSG00000237197", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Protein", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0001413", + "subject_id": "UMLS:C0001347", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5921,11 +5879,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C1099354", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5934,24 +5892,24 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "DOID:0080909", - "object_id": "UMLS:C3827014", + "subject_id": "UBERON:0000044", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "UMLS:C0010726", + "subject_id": "MESH:C000606896", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5960,24 +5918,24 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "UMLS:C0006556", + "subject_id": "UMLS:C0005615", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Cell", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "UMLS:C0001457", + "subject_id": "UMLS:C0001280", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -5986,37 +5944,37 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Disease", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0006556", + "subject_id": "DOID:3044", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Cell", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009528", - "object_id": "UMLS:C0023823", + "subject_id": "UMLS:C0004112", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211599", - "object_id": "UMLS:C0012929", + "subject_id": "UMLS:C0017952", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6025,63 +5983,76 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001098", - "object_id": "UMLS:C0012929", + "subject_id": "UBERON:0000004", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0006556", + "subject_id": "PUBCHEM.COMPOUND:10089466", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", "subject_id": "HP:0000718", - "object_id": "UMLS:C0012929", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0001457", + "subject_id": "UMLS:C0003261", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "UMLS:C1099354", + "subject_id": "UMLS:C0017262", + "object_id": "MESH:D016753", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:Device", + "object_category": "biolink:BiologicalEntity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0115137", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6091,49 +6062,49 @@ }, { "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "UMLS:C0012931", + "subject_id": "UMLS:C0013081", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Drug", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005839", - "object_id": "UMLS:C1099354", + "subject_id": "UMLS:C0001648", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Behavior", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0012476", + "subject_id": "UMLS:C0004268", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0001413", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6143,23 +6114,23 @@ }, { "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0012929", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Drug", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009928", - "object_id": "UMLS:C0003921", + "subject_id": "MESH:D005620", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6168,102 +6139,102 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Drug", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0003308", + "subject_id": "UMLS:C0449238", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Protein", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0019046", + "subject_id": "UMLS:C0205161", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:3043", - "object_id": "PUBCHEM.COMPOUND:24529", + "subject_id": "UMLS:C0178587", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "molecular_modification" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P69905", - "object_id": "PUBCHEM.COMPOUND:24529", + "subject_id": "NCBIGene:1218", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "molecular_modification" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2095222", - "object_id": "PR:000007581", + "subject_id": "UMLS:C0012929", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:133", - "object_id": "CHEMBL.COMPOUND:CHEMBL4650434", + "subject_id": "UMLS:C0040669", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:OrganismAttribute", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "DOID:3044", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0020969", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0085295", + "subject_id": "HP:0003651", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6272,37 +6243,37 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Activity", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C410027", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0237820", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C000589760", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C1167395", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000237197", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0598958", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6311,232 +6282,232 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Food", "object_category": "biolink:BiologicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005615", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0006494", + "object_id": "MESH:D016753", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0009368", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001046", + "object_id": "UMLS:C0006104", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000004", - "object_id": "UMLS:C0085295", + "subject_id": "NCBIGene:100996949", + "object_id": "UMLS:C0040300", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0021228", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0014631", + "object_id": "UMLS:C1304649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001347", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001390", + "object_id": "UBERON:0006134", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "UMLS:C0085295", + "subject_id": "PUBCHEM.COMPOUND:453626", + "object_id": "PUBCHEM.COMPOUND:130074", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0085295", + "subject_id": "CHEMBL.TARGET:CHEMBL2364159", + "object_id": "CHEMBL.COMPOUND:CHEMBL4297229", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0000254", + "object_id": "UBERON:0001037", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017952", - "object_id": "UMLS:C0085295", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UBERON:0001638", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11155873", - "object_id": "UMLS:C0085295", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UBERON:0000323", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:D005620", - "object_id": "UMLS:C0085295", + "subject_id": "ENSEMBL:ENSG00000211934", + "object_id": "UBERON:0002107", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "UMLS:C0085295", + "subject_id": "MESH:D002186", + "object_id": "UBERON:0000922", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0205161", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0011324", + "object_id": "UBERON:0001831", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Drug", - "object_category": "biolink:BiologicalEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001648", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001046", + "object_id": "UBERON:0003126", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "UMLS:C0085295", + "subject_id": "DRUGBANK:DB14329", + "object_id": "UMLS:C0037732", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0178587", - "object_id": "UMLS:C0085295", + "subject_id": "NCBIGene:10129", + "object_id": "UMLS:C0037732", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1218", - "object_id": "UMLS:C0085295", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6545,50 +6516,50 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001811", + "object_id": "UMLS:C1518478", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017262", - "object_id": "UMLS:C0085295", + "subject_id": "HP:0000718", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0012222", + "object_id": "UMLS:C0206136", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0598958", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0001642", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6597,11 +6568,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0115137", - "object_id": "UMLS:C0085295", + "subject_id": "HP:0001518", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6610,24 +6581,24 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0085295", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012929", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0003015", + "object_id": "UMLS:C0037570", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6636,37 +6607,37 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0008858", + "object_id": "UMLS:C0376596", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0085295", + "subject_id": "UMLS:C0017127", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C1440605", - "object_id": "UMLS:C0085295", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0353942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6675,115 +6646,115 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:BiologicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0085295", + "subject_id": "UBERON:0000948", + "object_id": "UMLS:C0206136", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2095182", - "object_id": "PUBCHEM.COMPOUND:11284169", + "subject_id": "UMLS:C0017255", + "object_id": "UMLS:C0376596", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Activity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P24462", - "object_id": "PUBCHEM.COMPOUND:9852188", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0353942", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Food", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0178587", - "object_id": "MESH:D013205", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Gene", + "subject_category": "biolink:Cell", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "NCBIGene:2081", + "subject_id": "UMLS:C0014597", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "NCBIGene:3565", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "NCBIGene:10106", + "subject_id": "UMLS:C0428696", + "object_id": "UMLS:C0938430", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Disease", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150598", - "object_id": "NCBIGene:1789", + "subject_id": "MONDO:0001076", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "NCBIGene:2357", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6792,63 +6763,63 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Protein", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0005456", + "subject_id": "UMLS:C0002085", + "object_id": "UBERON:0000922", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Device", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:C015428", - "object_id": "UMLS:C0350056", + "subject_id": "UMLS:C0001390", + "object_id": "UBERON:0000992", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:C000521", - "object_id": "UMLS:C0043076", + "subject_id": "MESH:D000090982", + "object_id": "UBERON:0001986", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Device", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "HP:0000505", - "object_id": "UMLS:C0165528", + "subject_id": "UMLS:C0178587", + "object_id": "MESH:D013205", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Gene", "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364159", - "object_id": "CHEMBL.COMPOUND:CHEMBL4297229", + "subject_id": "NCBIGene:2243", + "object_id": "CHEBI:8583", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6857,102 +6828,102 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Drug", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0013227", + "subject_id": "UMLS:C0020964", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Disease", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "UMLS:C0002198", + "subject_id": "MONDO:0000248", + "object_id": "UMLS:C0011313", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "UBERON:0001037", + "subject_id": "MESH:C454062", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Behavior", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211934", - "object_id": "UBERON:0002107", + "subject_id": "UMLS:C0004268", + "object_id": "UMLS:C5202641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UBERON:0001638", + "subject_id": "UMLS:C0026237", + "object_id": "UMLS:C5202641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011324", - "object_id": "UBERON:0001831", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C5202641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Food", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001642", - "object_id": "UMLS:C0012171", + "subject_id": "UMLS:C0449238", + "object_id": "UBERON:0000044", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Food", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "HP:0001518", - "object_id": "UMLS:C0078479", + "subject_id": "MESH:D005620", + "object_id": "UMLS:C0027882", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6961,11 +6932,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Food", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10129", - "object_id": "UMLS:C0037732", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -6974,115 +6945,115 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Food", + "subject_category": "biolink:Cell", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008858", - "object_id": "UMLS:C0376596", + "subject_id": "UMLS:C0004561", + "object_id": "MESH:D000090982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Food", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C1167395", + "object_id": "NCBIGene:10133", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Food", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "UMLS:C0012171", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2107873", + "object_id": "NCBIGene:2157", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Food", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0000948", - "object_id": "UMLS:C0206136", + "subject_id": "MESH:D000086942", + "object_id": "HGNC:39025", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0014597", - "object_id": "UMLS:C0012171", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0037570", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "UMLS:C0012171", + "subject_id": "UMLS:C0596962", + "object_id": "UMLS:C1449651", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Food", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012222", - "object_id": "UMLS:C0206136", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201203", + "object_id": "HP:0002307", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Food", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017255", - "object_id": "UMLS:C0376596", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "NCIT:C120860", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Food", + "subject_category": "biolink:Cell", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0353942", + "subject_id": "UMLS:C0003315", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7091,37 +7062,37 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Food", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0353942", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C1318415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Food", + "subject_category": "biolink:Behavior", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0037322", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Food", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023823", - "object_id": "UMLS:C0012171", + "subject_id": "UMLS:C0017952", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7131,66 +7102,62 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UniProtKB:P01857", - "object_id": "CHEMBL.COMPOUND:CHEMBL4297981", + "subject_id": "UMLS:C0000107", + "object_id": "UMLS:C1272641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:Drug", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UMLS:C0006104", + "subject_id": "UMLS:C0001637", + "object_id": "HP:0012533", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020964", - "object_id": "MESH:D020077", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C1444783", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:C048844", - "object_id": "UMLS:C1440597", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "HGNC:12529", - "object_id": "UMLS:C0696946", + "subject_id": "HP:0004324", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7199,115 +7166,115 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C5202641", + "subject_id": "MESH:D002186", + "object_id": "NCIT:C116600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Cell", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "MESH:D020077", + "subject_id": "UMLS:C0005821", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0005456", + "subject_id": "DOID:3044", + "object_id": "HP:0002015", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Gene", - "object_category": "biolink:Drug", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2153", - "object_id": "RXNORM:352374", + "subject_id": "NCBIGene:100381270", + "object_id": "UMLS:C0543421", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "DrugCentral:4248", - "object_id": "NCBIGene:3784", + "subject_id": "UMLS:C0010423", + "object_id": "HP:0045047", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Gene", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "RXNORM:352374", - "object_id": "NCBIGene:2153", + "subject_id": "HP:0000020", + "object_id": "HP:0002607", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026377", - "object_id": "NCBIGene:9531", + "subject_id": "UMLS:C0003259", + "object_id": "UMLS:C1516006", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2107873", - "object_id": "NCBIGene:2157", + "subject_id": "UMLS:C0026882", + "object_id": "HP:0045047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Gene", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "HGNC:39025", + "subject_id": "UMLS:C0238876", + "object_id": "UMLS:C0034917", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7316,11 +7283,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:affects", - "subject_id": "NCBIGene:10062", - "object_id": "CHEMBL.COMPOUND:CHEMBL3545047", + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001563", + "object_id": "UMLS:C0578019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7329,24 +7296,24 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "NCBIGene:116833", - "object_id": "UMLS:C0225336", + "subject_id": "UBERON:0000310", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D005620", - "object_id": "UMLS:C0027882", + "subject_id": "NCBIGene:2489", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7355,24 +7322,24 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Cell", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515464", - "object_id": "UMLS:C0007600", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0001280", + "subject_id": "UBERON:0002481", + "object_id": "UMLS:C0033684", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7381,102 +7348,102 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Cell", + "subject_category": "biolink:MolecularEntity", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005773", - "object_id": "UMLS:C0879438", + "subject_id": "CHEMBL.TARGET:CHEMBL2364181", + "object_id": "PUBCHEM.COMPOUND:8519", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UBERON:0000948", + "subject_id": "PUBCHEM.COMPOUND:23663392", + "object_id": "CHEMBL.COMPOUND:CHEMBL1201636", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UBERON:0000948", + "subject_id": "UMLS:C0009528", + "object_id": "UMLS:C0023823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Gene", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UBERON:0003126", + "subject_id": "ENSEMBL:ENSG00000211599", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Food", + "subject_category": "biolink:Cell", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0037570", + "subject_id": "UMLS:C0004112", + "object_id": "UMLS:C0001457", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Protein", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0596962", - "object_id": "UMLS:C1449651", + "subject_id": "UBERON:0000007", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "HP:0031925", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017952", - "object_id": "UMLS:C0034917", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7485,24 +7452,24 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Cell", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000107", - "object_id": "UMLS:C1272641", + "subject_id": "UMLS:C0003315", + "object_id": "UMLS:C0012476", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201203", - "object_id": "HP:0002307", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0010726", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7511,24 +7478,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C1318415", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Drug", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100381270", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C0010726", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7537,154 +7491,154 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "DOID:3044", - "object_id": "HP:0002015", + "subject_id": "UMLS:C0001098", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0034917", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Disease", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C1444783", + "subject_id": "DOID:0080909", + "object_id": "UMLS:C1101610", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0000310", - "object_id": "UMLS:C0543421", + "subject_id": "HP:0000718", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "UMLS:C0543421", + "subject_id": "MESH:D002186", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "HP:0004324", - "object_id": "UMLS:C0034917", + "subject_id": "UMLS:C0005839", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UMLS:C0489618", + "subject_id": "UMLS:C0002345", + "object_id": "UMLS:C0073432", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003259", - "object_id": "UMLS:C1516006", + "subject_id": "UMLS:C0001038", + "object_id": "UMLS:C0012931", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0010423", - "object_id": "HP:0045047", + "subject_id": "UMLS:C0001383", + "object_id": "UMLS:C0001390", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026882", - "object_id": "HP:0045047", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0001390", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "HP:0000020", - "object_id": "HP:0002607", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001563", - "object_id": "UMLS:C0578019", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7693,63 +7647,63 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238876", - "object_id": "UMLS:C0034917", + "subject_id": "PUBCHEM.COMPOUND:126941", + "object_id": "CHEMBL.COMPOUND:CHEMBL1863515", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "NCIT:C116600", + "subject_id": "CHEBI:3815", + "object_id": "CHEMBL.COMPOUND:CHEMBL2095222", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005821", - "object_id": "UMLS:C0543421", + "subject_id": "PUBCHEM.COMPOUND:453626", + "object_id": "MESH:D002097", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037322", - "object_id": "UMLS:C0034917", + "subject_id": "PUBCHEM.COMPOUND:33887", + "object_id": "UMLS:C0150479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0543421", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0001280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7758,11 +7712,11 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "HP:0001945", + "subject_id": "UMLS:C0428696", + "object_id": "UMLS:C0938430", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7771,197 +7725,158 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "UMLS:C0033684", + "subject_id": "NCBIGene:116833", + "object_id": "UMLS:C0225336", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularEntity", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2364181", - "object_id": "PUBCHEM.COMPOUND:8519", + "subject_id": "UMLS:C1515464", + "object_id": "UMLS:C0007600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Gene", + "subject_category": "biolink:Cell", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "NCBIGene:10216", + "subject_id": "UMLS:C0005773", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0009368", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0018956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:126941", - "object_id": "CHEMBL.COMPOUND:CHEMBL1863515", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0004112", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:3815", - "object_id": "CHEMBL.COMPOUND:CHEMBL2095222", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C0004561", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Gene", + "subject_category": "biolink:Cell", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "NCBIGene:3156", + "subject_id": "UMLS:C0004561", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "NCBIGene:3497", + "subject_id": "UMLS:C0005938", + "object_id": "NCBIGene:10216", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:ChemicalEntity", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "MESH:D002097", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:439302", - "object_id": "MESH:C588202", + "subject_id": "UMLS:C0002085", + "object_id": "UBERON:0001876", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Protein", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0665341", - "object_id": "CHEMBL.COMPOUND:CHEMBL4650316", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", - "predicate": "biolink:affects", - "subject_id": "NCBIGene:8081", - "object_id": "PUBCHEM.COMPOUND:92337", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "UBERON:0000922", + "subject_id": "UMLS:C0000254", + "object_id": "MESH:D010861", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100294715", - "object_id": "UBERON:0001264", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "MESH:D000069261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UBERON:0000007", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0007610", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -7982,8 +7897,8 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:3779", - "object_id": "NCBIGene:6647", + "subject_id": "PUBCHEM.COMPOUND:23634441", + "object_id": "NCBIGene:2034", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -7992,184 +7907,132 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "MESH:D004721", + "subject_id": "CHEBI:61995", + "object_id": "UBERON:0000323", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "MESH:D010861", + "subject_id": "NCBIGene:100329167", + "object_id": "UBERON:0002114", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "MESH:D008247", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:AnatomicalEntity", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:100294715", - "object_id": "UMLS:C0024109", + "subject_id": "ENSEMBL:ENSG00000211666", + "object_id": "UMLS:C0025979", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:PhysicalEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0007531", + "subject_id": "UMLS:C0037392", + "object_id": "UMLS:C0018563", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0018956", + "subject_id": "UMLS:C0449238", + "object_id": "UBERON:0000947", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Cell", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0004112", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:Cell", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "UMLS:C0879438", + "subject_id": "MESH:D016753", + "object_id": "UBERON:0000004", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C1178562", - "object_id": "UMLS:C0039194", + "subject_id": "CHEBI:60160", + "object_id": "UBERON:0000043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0014631", - "object_id": "UMLS:C1304649", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:GrossAnatomicalStructure", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UBERON:0000922", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0006104", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", "subject_id": "CHEBI:61995", - "object_id": "UBERON:0000323", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:CellularComponent", - "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211666", - "object_id": "UMLS:C0025979", + "object_id": "UBERON:0000044", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UBERON:0001876", + "subject_id": "NCBITaxon:11089", + "object_id": "UMLS:C0024204", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8177,64 +8040,64 @@ "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "MESH:D016753", "object_id": "UBERON:0000044", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "UMLS:C0035553", + "subject_id": "HP:0002607", + "object_id": "UMLS:C1409894", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:NamedThing", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10255", - "object_id": "UBERON:0001048", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C1184738", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000728", - "object_id": "UBERON:0001048", + "subject_id": "UMLS:C1373124", + "object_id": "UBERON:0000178", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0029960", - "object_id": "UBERON:0001048", + "subject_id": "NCBIGene:100329167", + "object_id": "UMLS:C0026046", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8242,77 +8105,77 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "MESH:D008930", + "subject_id": "UMLS:C0001390", + "object_id": "MESH:D002736", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Drug", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "MESH:D002462", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C0035553", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:NamedThing", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100329167", - "object_id": "UMLS:C0026046", + "subject_id": "MESH:D000090982", + "object_id": "MESH:D055354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0008633", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0026237", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0026237", + "subject_id": "UMLS:C0002085", + "object_id": "MESH:D064201", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MESH:D064201", + "subject_id": "CHEBI:61995", + "object_id": "MESH:D002462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8320,38 +8183,38 @@ "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "MESH:D016753", "object_id": "MESH:D000067128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000107", - "object_id": "UMLS:C1272641", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Protein", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "HP:0001944", + "subject_id": "UMLS:C0000107", + "object_id": "UMLS:C1272641", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8364,20 +8227,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "HP:0003287", + "subject_id": "CHEBI:61995", + "object_id": "HP:0001824", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8386,11 +8249,11 @@ "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", "subject_id": "MESH:C002502", - "object_id": "UMLS:C0332124", + "object_id": "UMLS:C0231239", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8408,63 +8271,37 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UBERON:0000044", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:GrossAnatomicalStructure", - "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UBERON:0001003", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:GrossAnatomicalStructure", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UBERON:0000004", + "subject_id": "PUBCHEM.COMPOUND:10255", + "object_id": "UBERON:0001048", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "UMLS:C0016030", + "subject_id": "MESH:D000728", + "object_id": "UBERON:0001048", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Cell", + "subject_category": "biolink:Protein", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0007600", + "subject_id": "UMLS:C0003009", + "object_id": "UBERON:0014374", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8473,145 +8310,145 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Cell", + "subject_category": "biolink:Cell", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0024432", + "subject_id": "UMLS:C0027950", + "object_id": "CHEMBL.TARGET:CHEMBL2367389", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UBERON:0010163", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2110627", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Protein", - "object_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000084", - "object_id": "UMLS:C0596290", + "subject_id": "UMLS:C0001239", + "object_id": "UMLS:C1510470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000805", - "object_id": "UMLS:C0025344", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037392", - "object_id": "UMLS:C0018563", + "subject_id": "HP:0045047", + "object_id": "UBERON:0001003", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEBI:60160", - "object_id": "UBERON:0000043", + "subject_id": "CHEBI:61452", + "object_id": "UMLS:C0016030", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:CellularComponent", - "object_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0006104", + "object_id": "UMLS:C0007600", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBITaxon:11089", - "object_id": "UMLS:C0024204", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0024432", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "HP:0002607", - "object_id": "UMLS:C1409894", + "subject_id": "UMLS:C0000805", + "object_id": "UMLS:C0025344", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373124", - "object_id": "UBERON:0000178", + "subject_id": "UMLS:C0000084", + "object_id": "UMLS:C0596290", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:PopulationOfIndividualOrganisms", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0006104", + "subject_id": "UMLS:C0696628", + "object_id": "UBERON:0010163", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8624,7 +8461,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:Cell", + "object_category": "biolink:GrossAnatomicalStructure", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0039194", + "object_id": "UBERON:0002481", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, @@ -8637,7 +8487,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8650,163 +8500,176 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2110627", - "object_id": "UMLS:C0178587", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0009013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001239", - "object_id": "UMLS:C1510470", + "subject_id": "UMLS:C0002345", + "object_id": "UMLS:C0007586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "UMLS:C0178587", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "UMLS:C0029965", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0039194", - "object_id": "UBERON:0002481", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UMLS:C0007608", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0027950", - "object_id": "CHEMBL.TARGET:CHEMBL2367373", + "subject_id": "ENSEMBL:ENSG00000211596", + "object_id": "UMLS:C0162638", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "PUBCHEM.COMPOUND:44135672", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0000934", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Gene", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "NCBIGene:100996939", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0001272", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCBIGene:10777", + "subject_id": "RXNORM:1246101", + "object_id": "UMLS:C0018270", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Gene", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003920", - "object_id": "NCBIGene:6523", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C0596290", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Gene", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "NCBIGene:100289419", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C0020964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Gene", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "NCBIGene:100124700", + "subject_id": "GO:0000012", + "object_id": "GO:1903517", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:BiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "GO:0000012", + "object_id": "GO:1903518", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", "object_id": "MONDO:0001076", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -8819,16 +8682,16 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "UMLS:C1525451", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201469", + "object_id": "MESH:D002462", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8837,11 +8700,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201469", - "object_id": "MESH:D002462", + "subject_id": "UMLS:C0033607", + "object_id": "MESH:D000088502", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8850,10 +8713,10 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Gene", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085268", + "subject_id": "NCBIGene:2475", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -8863,10 +8726,10 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:5284616", + "subject_id": "MESH:D012333", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -8876,10 +8739,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:C546842", + "subject_id": "PUBCHEM.COMPOUND:5284616", "object_id": "UBERON:0002481", "qualifiers": [ { @@ -8902,11 +8765,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:27", - "object_id": "UBERON:0006907", + "subject_id": "UMLS:C0085268", + "object_id": "UBERON:0002481", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -8923,254 +8786,241 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "UMLS:C0007586", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C1335464", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211596", - "object_id": "UMLS:C0162638", + "subject_id": "UMLS:C0012872", + "object_id": "PUBCHEM.COMPOUND:44135672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Device", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0007587", + "subject_id": "UMLS:C0003072", + "object_id": "NCBIGene:3156", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0000934", + "subject_id": "MESH:D008925", + "object_id": "NCBIGene:3497", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UMLS:C0007608", + "subject_id": "UMLS:C0033213", + "object_id": "NCBIGene:100996939", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C0596290", + "subject_id": "CHEBI:60027", + "object_id": "NCBIGene:3757", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Food", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "KEGG.DRUG:D10748", - "object_id": "UMLS:C0162638", + "subject_id": "UMLS:C0003920", + "object_id": "NCBIGene:6523", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0007587", + "subject_id": "UMLS:C0020969", + "object_id": "NCBIGene:100289419", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0012238", + "subject_id": "UMLS:C0015919", + "object_id": "NCBIGene:10777", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903517", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Publication", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903518", + "subject_id": "UMLS:C0599740", + "object_id": "NCBIGene:10013", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903517", + "subject_id": "DOID:0080747", + "object_id": "MONDO:0005492", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000012", - "object_id": "GO:1903518", + "subject_id": "CHEBI:146214", + "object_id": "UMLS:C0006906", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Cell", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2367373", - "object_id": "UMLS:C0027950", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0004048", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Cell", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "UMLS:C0027950", + "subject_id": "UMLS:C0001046", + "object_id": "UMLS:C0034965", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Cell", + "subject_category": "biolink:Activity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UBERON:0000970", - "object_id": "UMLS:C0879438", + "subject_id": "UMLS:C0015746", + "object_id": "UMLS:C0005823", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Disease", + "subject_category": "biolink:Device", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "DOID:0080747", - "object_id": "MONDO:0005492", + "subject_id": "UMLS:C0002671", + "object_id": "UMLS:C0018270", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004302", - "object_id": "UMLS:C1515464", + "subject_id": "UMLS:C0675244", + "object_id": "UMLS:C0225828", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UBERON:0000310", + "subject_id": "HP:0000718", "object_id": "UMLS:C1520381", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9183,29 +9033,29 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:Protein", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "UMLS:C0008546", + "subject_id": "UMLS:C0002957", + "object_id": "UMLS:C0035702", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Cell", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0675244", - "object_id": "UMLS:C0225828", + "subject_id": "NCBIGene:100528023", + "object_id": "UMLS:C0073434", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9214,106 +9064,54 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "MESH:C106801", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0012868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:CellularComponent", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "UMLS:C1520381", + "subject_id": "HP:0001945", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004268", - "object_id": "UMLS:C0012476", + "subject_id": "MESH:D003850", + "object_id": "UMLS:C0012925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Activity", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0012868", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "HP:0001945", + "subject_id": "UMLS:C0237820", "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0002345", - "object_id": "UMLS:C0073432", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0012925", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:100528023", - "object_id": "UMLS:C0073434", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9326,28 +9124,15 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Activity", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0001413", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "UMLS:C0449238", "object_id": "UMLS:C0012929", "qualifiers": [ { @@ -9357,11 +9142,11 @@ ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "UMLS:C1099354", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0012929", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9400,7 +9185,7 @@ "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", "subject_id": "UBERON:0002481", - "object_id": "MESH:C546842", + "object_id": "MESH:D012333", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9429,8 +9214,21 @@ "object_id": "NCBIGene:25799", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:CellularComponent", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0004302", + "object_id": "UMLS:C1515464", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, @@ -9443,7 +9241,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9482,72 +9280,59 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0013936", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:146214", - "object_id": "UMLS:C0006906", + "subject_id": "UBERON:0000310", + "object_id": "UMLS:C1520381", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UMLS:C0034965", + "subject_id": "CHEMBL.TARGET:CHEMBL2367389", + "object_id": "UMLS:C0027950", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015746", - "object_id": "UMLS:C0005823", + "subject_id": "UMLS:C1115729", + "object_id": "UMLS:C0027950", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002671", - "object_id": "UMLS:C0018270", + "subject_id": "UBERON:0000970", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9573,7 +9358,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9604,15 +9389,28 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:CellularComponent", - "predicate": "biolink:affects", - "subject_id": "GO:0000001", - "object_id": "GO:0005739", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhysiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "NCBIGene:100188776", + "object_id": "UMLS:C0003618", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "MONDO:0004946", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, @@ -9625,7 +9423,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9638,7 +9436,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9651,46 +9449,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", - "predicate": "biolink:causes", - "subject_id": "MESH:D000071439", - "object_id": "UMLS:C0085187", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Device", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C0003618", + "subject_id": "UMLS:C0450138", + "object_id": "MESH:D016207", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0450138", - "object_id": "MESH:D016207", + "subject_id": "MESH:D000071439", + "object_id": "UMLS:C0085187", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9703,16 +9488,16 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211625", - "object_id": "UMLS:C0598958", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108278", + "object_id": "CHEMBL.TARGET:CHEMBL3826826", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9738,11 +9523,11 @@ "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", "subject_id": "UMLS:C0002345", - "object_id": "UMLS:C0009802", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9760,54 +9545,41 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201512", - "object_id": "CHEMBL.TARGET:CHEMBL2364186", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "UMLS:C1373051", + "subject_id": "MESH:D020077", "object_id": "UBERON:0000948", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:GrossAnatomicalStructure", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", + "subject_id": "UMLS:C1373051", "object_id": "UBERON:0000948", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "NCBIGene:11", - "object_id": "MESH:D016824", + "subject_id": "UMLS:C0369078", + "object_id": "UMLS:C0024432", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -9815,12 +9587,12 @@ "subject_category": "biolink:Polypeptide", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "HP:0002045", + "subject_id": "UMLS:C0001390", + "object_id": "HP:0003287", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9846,33 +9618,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "HP:0003651", + "subject_id": "UMLS:C0001046", + "object_id": "HP:0010546", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "HP:0010546", + "subject_id": "MESH:D016753", + "object_id": "HP:0003651", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -9881,7 +9653,7 @@ "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0023823", + "object_id": "UMLS:C0001390", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -9898,7 +9670,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9928,32 +9700,6 @@ } ] }, - { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Cell", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0369078", - "object_id": "UMLS:C0024432", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "MONDO:0005271", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, { "subject_category": "biolink:Food", "object_category": "biolink:CellularComponent", @@ -9963,7 +9709,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -9981,76 +9727,63 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0000084", - "object_id": "UMLS:C1148561", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211598", - "object_id": "UMLS:C1150132", + "subject_id": "UMLS:C5202641", + "object_id": "UMLS:C0026237", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211625", - "object_id": "UMLS:C0600436", + "subject_id": "CHEBI:60027", + "object_id": "MESH:D021982", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UMLS:C0031715", + "subject_id": "GO:0000104", + "object_id": "GO:1904230", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0243102", + "subject_id": "GO:0000104", + "object_id": "GO:1904231", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Protein", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0243102", + "subject_id": "UMLS:C0000084", + "object_id": "UMLS:C1148561", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -10059,223 +9792,223 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0001801", + "subject_id": "UMLS:C0376452", + "object_id": "UMLS:C0007620", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularActivity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0008858", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0016315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularActivity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "MESH:D000073893", - "object_id": "UMLS:C0599861", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UMLS:C0016315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0006469", - "object_id": "GO:0004672", + "subject_id": "UMLS:C0000254", + "object_id": "UMLS:C0016315", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0000014", - "object_id": "GO:1990600", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0010986", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0005495", + "subject_id": "ENSEMBL:ENSG00000211598", + "object_id": "UMLS:C0042765", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211598", - "object_id": "UMLS:C0042765", + "subject_id": "MESH:D000073893", + "object_id": "UMLS:C1160534", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Pathway", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0001961", - "object_id": "GO:0019221", + "subject_id": "MESH:D000438", + "object_id": "UMLS:C1160534", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Pathway", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0001960", - "object_id": "GO:0019221", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C0010423", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Pathway", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0001960", - "object_id": "GO:0019221", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", + "object_id": "UMLS:C0031715", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Pathway", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0000747", - "object_id": "GO:0032005", + "subject_id": "ENSEMBL:ENSG00000211598", + "object_id": "UMLS:C1150132", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0017715", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "UMLS:C0599476", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:C053313", - "object_id": "UMLS:C0031715", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0243102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0006469", - "object_id": "GO:0004672", + "subject_id": "MESH:D000073893", + "object_id": "UMLS:C0599861", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0007250", - "object_id": "GO:0004704", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0020964", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0007250", - "object_id": "GO:0004704", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0005615", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Disease", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "MONDO:0000088", + "subject_id": "UMLS:C0021498", + "object_id": "UMLS:C0023946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -10288,7 +10021,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -10301,228 +10034,228 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "HP:0000011", - "object_id": "MONDO:0001953", + "subject_id": "MESH:C002502", + "object_id": "MONDO:0029000", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:1901978", - "qualifiers": [ + "subject_id": "CHEBI:61995", + "object_id": "MONDO:0000984", + "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:1901978", + "subject_id": "UMLS:C0002085", + "object_id": "MONDO:0000723", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0003261", + "subject_id": "MESH:D000090982", + "object_id": "MONDO:0001358", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "UMLS:C0016315", + "subject_id": "UMLS:C0000702", + "object_id": "MONDO:0002363", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1163051", - "object_id": "UMLS:C0016315", + "subject_id": "NCBIGene:100187749", + "object_id": "MONDO:0005249", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Device", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904231", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0036679", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904231", + "subject_id": "MESH:D016753", + "object_id": "DOID:3044", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:affects", - "subject_id": "GO:0005739", - "object_id": "GO:0000001", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0015919", + "object_id": "MONDO:0005271", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "UMLS:C0010423", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0017262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0376452", - "object_id": "UMLS:C0007620", + "subject_id": "UMLS:C0000254", + "object_id": "UMLS:C0017262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MESH:D000073893", - "object_id": "UMLS:C1160534", + "subject_id": "UMLS:C0001272", + "object_id": "UMLS:C0017262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Phenomenon", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MESH:D000438", - "object_id": "UMLS:C1160534", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0162493", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Gene", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "UMLS:C0020291", + "subject_id": "ENSEMBL:ENSG00000211625", + "object_id": "UMLS:C0040649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904230", + "subject_id": "UMLS:C0001046", + "object_id": "UMLS:C0162493", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000104", - "object_id": "GO:1904230", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C0007581", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000237197", - "object_id": "UMLS:C0544461", + "subject_id": "NCBIGene:100188830", + "object_id": "UMLS:C0080129", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -10530,220 +10263,220 @@ "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007581", - "object_id": "UMLS:C0080129", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:Gene", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "UMLS:C0205254", + "subject_id": "ENSEMBL:ENSG00000237197", + "object_id": "UMLS:C0544461", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "UMLS:C0080129", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0009393", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "UMLS:C0080129", + "subject_id": "UMLS:C0017262", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0806909", + "subject_id": "MESH:D002186", + "object_id": "UMLS:C0205254", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079394", + "subject_id": "UMLS:C0013081", "object_id": "UMLS:C0080129", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1335464", - "object_id": "UMLS:C0080129", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0009393", + "subject_id": "MESH:D017729", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0001897", - "object_id": "UMLS:C1817204", + "subject_id": "UMLS:C0001046", + "object_id": "UMLS:C0599739", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "MESH:D020868", - "object_id": "UMLS:C2753196", + "subject_id": "GO:0000747", + "object_id": "GO:0032005", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001259", - "object_id": "UMLS:C0597295", + "subject_id": "ENSEMBL:ENSG00000211625", + "object_id": "UMLS:C0598958", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0013846", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0003319", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Gene", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0021498", - "object_id": "UMLS:C0023946", + "subject_id": "ENSEMBL:ENSG00000211625", + "object_id": "UMLS:C0600436", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0005615", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C0017715", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0003319", + "subject_id": "GO:0001960", + "object_id": "GO:0019221", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Pathway", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UMLS:C0599739", + "subject_id": "GO:0000075", + "object_id": "GO:0044770", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:Pathway", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "OBA:0000058", - "object_id": "GO:0051454", + "subject_id": "GO:0000075", + "object_id": "GO:1901978", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -10752,33 +10485,20 @@ "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", "subject_id": "OBA:0000058", - "object_id": "GO:0051452", + "object_id": "GO:0051454", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:GeneticInheritance", - "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0017260", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:NamedThing", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:1901977", + "subject_id": "OBA:0000058", + "object_id": "GO:0051452", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", @@ -10787,80 +10507,80 @@ ] }, { - "subject_category": "biolink:Pathway", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "GO:0000075", - "object_id": "GO:0044770", + "subject_id": "UMLS:C0015219", + "object_id": "UMLS:C1160466", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211625", - "object_id": "UMLS:C0040649", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0000854", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C1621985", - "object_id": "UMLS:C4759804", + "subject_id": "UMLS:C0001637", + "object_id": "UMLS:C0031164", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:Device", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015219", - "object_id": "UMLS:C1160466", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0009264", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0000854", + "subject_id": "NCBIGene:100188864", + "object_id": "UMLS:C0020291", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001637", - "object_id": "UMLS:C0031164", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -10873,33 +10593,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C5202641", + "subject_id": "UMLS:C0449238", "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188864", - "object_id": "UMLS:C0020291", + "subject_id": "UMLS:C5202641", + "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -10912,33 +10632,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0009264", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0003261", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:NamedThing", - "object_category": "biolink:Phenomenon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0016315", + "subject_id": "MESH:D000519", + "object_id": "UMLS:C0232804", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -10969,219 +10689,206 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D015942", - "object_id": "UMLS:C0005778", + "subject_id": "MESH:C053313", + "object_id": "UMLS:C0031715", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "UMLS:C0017262", + "subject_id": "GO:0000014", + "object_id": "GO:1990600", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "MONDO:0029000", + "subject_id": "GO:0007250", + "object_id": "GO:0004704", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "MONDO:0000723", + "subject_id": "UMLS:C0001259", + "object_id": "UMLS:C0597295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Disease", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000702", - "object_id": "MONDO:0002363", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0013846", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "DOID:3044", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0001801", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100187749", - "object_id": "MONDO:0005249", + "subject_id": "GO:0006469", + "object_id": "GO:0004672", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MONDO:0005271", + "subject_id": "GO:0000150", + "object_id": "GO:0140620", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "MONDO:0000984", + "subject_id": "HP:0004324", + "object_id": "UMLS:C0597832", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Disease", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0036679", + "subject_id": "NCBIGene:100188776", + "object_id": "UMLS:C1156201", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0017262", + "subject_id": "NCBIGene:100188784", + "object_id": "UMLS:C0597295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001272", - "object_id": "UMLS:C0017262", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0025723", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001046", - "object_id": "UMLS:C0162493", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0025246", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C0007581", + "subject_id": "MESH:D000519", + "object_id": "UMLS:C0596843", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0000150", - "object_id": "GO:0140620", + "subject_id": "UMLS:C0004391", + "object_id": "UMLS:C0597295", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Drug", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0003674", - "object_id": "GO:0140678", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "UMLS:C1156201", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C1152728", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11190,158 +10897,132 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C2612729", - "object_id": "GO:0090317", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1659201", - "object_id": "GO:0006342", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Food", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0090317", - "object_id": "UMLS:C2612729", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0023775", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0020964", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0017952", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003383", - "object_id": "UMLS:C1817666", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0025246", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0025723", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0005482", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Gene", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0003674", - "object_id": "GO:0140677", + "subject_id": "NCBIGene:10059", + "object_id": "GO:0065003", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Gene", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0025246", + "subject_id": "NCBIGene:10019", + "object_id": "GO:0035162", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188784", - "object_id": "UMLS:C0597295", + "subject_id": "UMLS:C0005938", + "object_id": "MONDO:0000088", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0023775", + "subject_id": "HP:0000011", + "object_id": "MONDO:0001953", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0005634", - "object_id": "GO:0000280", + "subject_id": "MONDO:0020724", + "object_id": "UMLS:C0162638", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "UMLS:C1152728", + "subject_id": "UMLS:C0000702", + "object_id": "UMLS:C1158517", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -11354,94 +11035,81 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0597360", + "subject_id": "NCBIGene:100188830", + "object_id": "UMLS:C0598312", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001457", - "object_id": "UMLS:C0031715", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0002345", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:BiologicalProcess", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10059", - "object_id": "GO:0065003", + "subject_id": "GO:0006914", + "object_id": "UMLS:C5137207", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10019", - "object_id": "GO:0035162", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "GO:0001208", - "object_id": "UMLS:C3822951", + "subject_id": "GO:0005634", + "object_id": "GO:0000280", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MONDO:0020724", - "object_id": "UMLS:C0162638", + "subject_id": "MESH:D003850", + "object_id": "UMLS:C0017259", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "HP:0004324", - "object_id": "UMLS:C0597832", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0033666", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11458,250 +11126,185 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:GeneticInheritance", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0017262", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0003674", - "object_id": "UMLS:C1817018", + "subject_id": "REACT:R-ALL-110644", + "object_id": "GO:0036175", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Device", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004391", - "object_id": "UMLS:C0597295", + "subject_id": "UMLS:C0035191", + "object_id": "UMLS:C0243102", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1817205", - "object_id": "GO:0001897", + "subject_id": "MESH:D000090982", + "object_id": "NCIT:C165206", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0017952", + "subject_id": "NCBIGene:100188776", + "object_id": "NCIT:C42083", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0017259", + "subject_id": "MESH:D016753", + "object_id": "HP:0000718", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "UMLS:C0598312", + "subject_id": "PUBCHEM.COMPOUND:10836", + "object_id": "UMLS:C0542299", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0013081", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0004268", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "REACT:R-ALL-110644", - "object_id": "GO:0036175", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" - } - ] - }, - { - "subject_category": "biolink:Device", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", - "object_id": "UMLS:C0243102", + "subject_id": "PUBCHEM.COMPOUND:11130", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C2259316", - "object_id": "UMLS:C2755759", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C2259320", - "object_id": "UMLS:C2755759", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Drug", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "UMLS:C0005520", + "subject_id": "UMLS:C0003921", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "UMLS:C0010423", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Food", - "object_category": "biolink:Phenomenon", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0013764", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "NCIT:C121964", + "subject_id": "HP:0025464", + "object_id": "UMLS:C1373120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188776", - "object_id": "NCIT:C42083", + "subject_id": "PATO:0000276", + "object_id": "GO:0090728", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "HP:0000718", + "subject_id": "PATO:0000276", + "object_id": "GO:0090727", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Gene", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10836", - "object_id": "UMLS:C0542299", + "subject_id": "NCBIGene:54209", + "object_id": "GO:0038160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11710,24 +11313,24 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Gene", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0004268", + "subject_id": "NCBIGene:10019", + "object_id": "GO:0038163", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Activity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003921", - "object_id": "UMLS:C0009928", + "subject_id": "UMLS:C0001288", + "object_id": "UMLS:C0150141", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11736,11 +11339,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11130", - "object_id": "UMLS:C0009928", + "subject_id": "UMLS:C0001560", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11749,88 +11352,75 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "HP:0025464", - "object_id": "UMLS:C1373120", + "subject_id": "CHEBI:60027", + "object_id": "UMLS:C0005520", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Food", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "PATO:0000276", - "object_id": "GO:0090728", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0013764", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "PATO:0000276", - "object_id": "GO:0090727", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:Gene", - "object_category": "biolink:Pathway", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:54209", - "object_id": "GO:0038160", + "subject_id": "HP:0045047", + "object_id": "UMLS:C0010423", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Pathway", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10019", - "object_id": "GO:0038163", + "subject_id": "CHEBI:60027", + "object_id": "UMLS:C1623047", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Procedure", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "CHEBI:60160", - "object_id": "UMLS:C0007577", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0004391", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MESH:C019760", + "subject_id": "NCBIGene:10045", "object_id": "UMLS:C1257756", "qualifiers": [ { @@ -11840,11 +11430,11 @@ ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005221", - "object_id": "UMLS:C1158013", + "subject_id": "MESH:C019760", + "object_id": "UMLS:C1257756", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11866,11 +11456,11 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Protein", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10045", - "object_id": "UMLS:C1257756", + "subject_id": "UMLS:C0005221", + "object_id": "UMLS:C1158013", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -11887,7 +11477,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -11900,72 +11490,59 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0015219", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C0032529", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1816627", - "object_id": "GO:0008233", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Procedure", - "object_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0004391", + "subject_id": "UMLS:C0087111", + "object_id": "UMLS:C0887912", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Activity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001560", - "object_id": "UMLS:C0237820", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0017262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Activity", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001288", - "object_id": "UMLS:C0150141", + "subject_id": "UMLS:C0012899", + "object_id": "UMLS:C0034865", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12004,85 +11581,46 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Pathway", + "object_category": "biolink:Pathway", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "UMLS:C0010357", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:Pathway", - "object_category": "biolink:Pathway", - "predicate": "biolink:causes", - "subject_id": "GO:0000165", - "object_id": "GO:0090080", + "subject_id": "GO:0000165", + "object_id": "GO:0090080", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:GeneticInheritance", - "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C1515670", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:GeneticInheritance", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012899", - "object_id": "UMLS:C0034865", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "upregulated" } ] }, { - "subject_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007742", - "object_id": "UMLS:C0018270", + "subject_id": "UMLS:C0282629", + "object_id": "UMLS:C0007587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:Publication", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0282629", - "object_id": "UMLS:C0007587", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0004391", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12095,20 +11633,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:CellularComponent", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C1335464", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12126,28 +11651,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL35084", - "object_id": "UMLS:C0871470", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Drug", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000251546", + "subject_id": "UMLS:C0001637", "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12160,7 +11685,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12168,21 +11693,21 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL783", + "subject_id": "CHEMBL.COMPOUND:CHEMBL35084", "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0007165", + "subject_id": "CHEMBL.COMPOUND:CHEMBL783", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12190,19 +11715,6 @@ } ] }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001637", - "object_id": "UMLS:C0007165", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, { "subject_category": "biolink:MolecularMixture", "object_category": "biolink:ClinicalAttribute", @@ -12212,46 +11724,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Protein", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001347", - "object_id": "UMLS:C0007165", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001637", - "object_id": "UMLS:C0034094", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:Device", - "object_category": "biolink:ClinicalAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0033086", - "object_id": "UMLS:C0026687", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12277,55 +11750,55 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:Gene", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007613", - "object_id": "UMLS:C0162765", + "subject_id": "ENSEMBL:ENSG00000251546", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Drug", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10954115", - "object_id": "GO:0006342", + "subject_id": "UMLS:C0001637", + "object_id": "UMLS:C0034094", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:23569", - "object_id": "GO:0036414", + "subject_id": "UMLS:C0001347", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Device", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001563", - "object_id": "UMLS:C1145676", + "subject_id": "UMLS:C0033086", + "object_id": "UMLS:C0026687", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12335,14 +11808,14 @@ }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:MolecularActivity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C1155544", - "object_id": "GO:0008545", + "subject_id": "UMLS:C0007613", + "object_id": "UMLS:C0162765", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, @@ -12355,7 +11828,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12368,7 +11841,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12376,12 +11849,12 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0023185", + "subject_id": "MESH:C000606101", + "object_id": "UMLS:C0679199", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12394,7 +11867,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12407,7 +11880,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12420,163 +11893,163 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Food", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100124700", - "object_id": "GO:0006342", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0031715", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Procedure", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005456", - "object_id": "GO:0006342", + "subject_id": "UMLS:C0001563", + "object_id": "UMLS:C1145676", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:C106801", - "object_id": "GO:0006342", + "subject_id": "UMLS:C0013081", + "object_id": "UMLS:C0376452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0003824", - "object_id": "UMLS:C2613285", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C0013081", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "UMLS:C0376452", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C1515670", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "MESH:D000076342", - "object_id": "GO:0018101", + "subject_id": "UMLS:C0007742", + "object_id": "UMLS:C0018270", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Gene", "object_category": "biolink:BiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C4321262", - "object_id": "GO:0018101", + "subject_id": "NCBIGene:10019", + "object_id": "GO:1990869", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:Drug", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0032529", + "subject_id": "UMLS:C0003204", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:C018362", - "object_id": "UMLS:C0031911", + "subject_id": "UMLS:C0000392", + "object_id": "UMLS:C0517355", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100289419", - "object_id": "UMLS:C0020969", + "subject_id": "MESH:C018362", + "object_id": "UMLS:C0031911", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Gene", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:100953062", + "subject_id": "NCBIGene:100289419", "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000392", - "object_id": "UMLS:C0517355", + "subject_id": "PUBCHEM.COMPOUND:100953062", + "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12589,7 +12062,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12602,7 +12075,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12615,20 +12088,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Food", - "object_category": "biolink:OrganismAttribute", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012171", - "object_id": "UMLS:C0020969", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12641,59 +12101,59 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003204", + "subject_id": "MESH:D020077", "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:BiologicalEntity", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", + "subject_id": "MESH:D016753", "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:Food", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "UMLS:C0012171", "object_id": "UMLS:C0020969", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0031715", + "subject_id": "UMLS:C3548866", + "object_id": "UMLS:C3547046", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, @@ -12706,7 +12166,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12719,20 +12179,72 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Disease", + "object_category": "biolink:GeneticInheritance", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0019054", + "object_id": "UMLS:C0599177", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0004391", + "subject_id": "UMLS:C3548866", + "object_id": "UMLS:C3547045", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:Disease", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "MONDO:0020724", + "object_id": "UMLS:C0031715", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:BiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "UMLS:C2262909", + "object_id": "GO:0006915", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:Publication", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0678607", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12745,7 +12257,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12758,7 +12270,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -12771,20 +12283,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismTaxon", - "predicate": "biolink:causes", - "subject_id": "MESH:D000073893", - "object_id": "UMLS:C1167395", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "upregulated" } ] }, @@ -12797,33 +12296,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Protein", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10133", + "subject_id": "UMLS:C0001924", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001924", + "subject_id": "MESH:D000073893", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12836,59 +12335,59 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012934", + "subject_id": "NCBIGene:10133", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MESH:D013638", + "subject_id": "PUBCHEM.COMPOUND:134156256", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031715", - "object_id": "UMLS:C1440453", + "subject_id": "UMLS:C0012934", + "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:134156256", + "subject_id": "MESH:D013638", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -12901,68 +12400,55 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "UMLS:C1515672", "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "MONDO:0020724", - "object_id": "UMLS:C0031715", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0318759", - "object_id": "UMLS:C1518440", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C1167395", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Cell", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBITaxon:5315", - "object_id": "UMLS:C0001811", + "subject_id": "UMLS:C0879438", + "object_id": "UMLS:C0020964", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0017127", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C0027793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -12984,24 +12470,24 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:Food", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0879438", - "object_id": "UMLS:C0020964", + "subject_id": "UMLS:C0037732", + "object_id": "UMLS:C0032058", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0027793", + "subject_id": "NCBITaxon:5315", + "object_id": "UMLS:C0001811", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13018,20 +12504,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "MONDO:0003634", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13044,7 +12517,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13057,7 +12530,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13070,7 +12543,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13088,54 +12561,54 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019054", - "object_id": "UMLS:C0599177", + "subject_id": "UMLS:C0699251", + "object_id": "UMLS:C0597295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0040649", + "subject_id": "PUBCHEM.COMPOUND:71306834", + "object_id": "UMLS:C1257756", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:OrganismTaxon", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515979", - "object_id": "UMLS:C0040649", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0015219", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Food", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0015219", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0040649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13148,98 +12621,33 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Procedure", "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C0079394", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0004391", - "object_id": "GO:0006342", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Drug", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0001645", - "object_id": "GO:0006342", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "MESH:D007459", - "object_id": "GO:0006342", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0035736", - "object_id": "GO:0006342", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:BiologicalProcess", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0086908", - "object_id": "GO:0006342", + "subject_id": "UMLS:C1515979", + "object_id": "UMLS:C0040649", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:BiologicalProcess", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:GeneticInheritance", "predicate": "biolink:causes", - "subject_id": "UMLS:C0543421", - "object_id": "GO:0006342", + "subject_id": "UMLS:C0080129", + "object_id": "UMLS:C0079394", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13251,8 +12659,8 @@ "object_id": "GO:0010467", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, @@ -13265,7 +12673,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13283,10 +12691,10 @@ ] }, { - "subject_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003448", + "subject_id": "MESH:D004967", "object_id": "UMLS:C0031911", "qualifiers": [ { @@ -13296,10 +12704,10 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Drug", "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D004967", + "subject_id": "UMLS:C0003448", "object_id": "UMLS:C0031911", "qualifiers": [ { @@ -13335,28 +12743,28 @@ ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012899", - "object_id": "UMLS:C0013081", + "subject_id": "REACT:R-ALL-2022362", + "object_id": "REACT:R-HSA-2022403", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:GeneticInheritance", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:71306834", - "object_id": "UMLS:C1257756", + "subject_id": "UMLS:C0012899", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13364,8 +12772,8 @@ "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:23623", - "object_id": "UMLS:C0333350", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "MONDO:0005240", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13399,19 +12807,6 @@ } ] }, - { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "MESH:D008925", - "object_id": "MONDO:0002406", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, { "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:PhysiologicalProcess", @@ -13434,7 +12829,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13447,20 +12842,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularActivity", - "predicate": "biolink:causes", - "subject_id": "REACT:R-ALL-2672379", - "object_id": "GO:0015280", - "qualifiers": [ - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, @@ -13473,7 +12855,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -13490,32 +12872,6 @@ } ] }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Behavior", - "predicate": "biolink:causes", - "subject_id": "NCBIGene:100271694", - "object_id": "UMLS:C0237529", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Device", - "object_category": "biolink:PhenotypicFeature", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "NCIT:C35041", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, { "subject_category": "biolink:Drug", "object_category": "biolink:Behavior", @@ -13525,55 +12881,55 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0175631", + "subject_id": "NCBIGene:100271694", + "object_id": "UMLS:C0237529", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025265", - "object_id": "UMLS:C1521104", + "subject_id": "UMLS:C0178587", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Device", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MONDO:0001056", - "object_id": "UMLS:C1520300", + "subject_id": "UMLS:C0003072", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025246", - "object_id": "MESH:D000086942", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0812399", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13582,63 +12938,63 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "MESH:D000086942", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C1160534", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Protein", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034865", - "object_id": "MESH:D000086942", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C1160534", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0812399", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C0025265", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C1160534", + "subject_id": "UMLS:C0675244", + "object_id": "UMLS:C0596578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Procedure", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C1160534", + "subject_id": "UMLS:C0001701", + "object_id": "UMLS:C0019868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13660,15 +13016,15 @@ ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Cell", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "UMLS:C0005482", + "subject_id": "UMLS:C0004561", + "object_id": "UMLS:C1515672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13681,7 +13037,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13694,42 +13050,68 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:GeneticInheritance", "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "MESH:D021982", + "subject_id": "UMLS:C0034865", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Activity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007587", - "object_id": "UMLS:C0282629", + "subject_id": "UMLS:C0237820", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Disease", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001701", - "object_id": "UMLS:C0019868", + "subject_id": "MONDO:0001056", + "object_id": "UMLS:C1520300", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:Behavior", + "object_category": "biolink:CellularComponent", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0025265", + "object_id": "UMLS:C1521104", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:CellularComponent", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0025246", + "object_id": "MESH:D000086942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13738,11 +13120,24 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035028", - "object_id": "UMLS:C0019868", + "subject_id": "UMLS:C0007587", + "object_id": "UMLS:C0282629", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:Procedure", + "object_category": "biolink:Behavior", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0004933", + "object_id": "UMLS:C0032942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13751,15 +13146,15 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Activity", "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0675244", - "object_id": "UMLS:C0596578", + "subject_id": "UMLS:C0035028", + "object_id": "UMLS:C0019868", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -13785,7 +13180,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13816,15 +13211,28 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Behavior", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004933", - "object_id": "UMLS:C0032942", + "subject_id": "UMLS:C3547045", + "object_id": "UMLS:C3548866", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C3547046", + "object_id": "UMLS:C3548866", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" } ] }, @@ -13837,7 +13245,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Behavior", + "predicate": "biolink:causes", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0004268", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, @@ -13850,7 +13271,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -13876,29 +13297,29 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Drug", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "UMLS:C0013227", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C0001701", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:ClinicalAttribute", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001288", - "object_id": "UMLS:C0033970", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0004910", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13907,11 +13328,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201203", - "object_id": "UMLS:C0806909", + "subject_id": "HP:0004370", + "object_id": "UMLS:C0021495", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13920,11 +13341,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0806909", + "subject_id": "UMLS:C0001288", + "object_id": "UMLS:C0033970", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13933,11 +13354,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Behavior", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025513", - "object_id": "UMLS:C0394162", + "subject_id": "UMLS:C0009990", + "object_id": "UMLS:C0025991", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13946,11 +13367,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0233929", - "object_id": "UMLS:C0002996", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201203", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13959,11 +13380,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C0001701", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -13972,15 +13393,15 @@ ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0004383", - "object_id": "NCBIGene:2979", + "subject_id": "GO:0035162", + "object_id": "NCBIGene:10019", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "downregulated" } ] }, @@ -13988,25 +13409,25 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201203", - "object_id": "NCBIGene:6530", + "subject_id": "PUBCHEM.COMPOUND:11230", + "object_id": "NCBIGene:248", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:MolecularActivity", "object_category": "biolink:Gene", - "predicate": "biolink:affects", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2024517", - "object_id": "NCBIGene:1813", + "predicate": "biolink:causes", + "subject_id": "GO:0004383", + "object_id": "NCBIGene:2979", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] }, @@ -14020,32 +13441,41 @@ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "GO:0005219", + "object_id": "NCBIGene:1193", + "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "HP:0004370", - "object_id": "UMLS:C0021495", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201571", + "object_id": "NCBIGene:914", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Procedure", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0004910", + "subject_id": "UBERON:0002481", + "object_id": "NCBIGene:2475", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14054,11 +13484,11 @@ ] }, { - "subject_category": "biolink:Behavior", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009990", - "object_id": "UMLS:C0025991", + "subject_id": "UMLS:C0086542", + "object_id": "UMLS:C0199176", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14067,49 +13497,41 @@ ] }, { - "subject_category": "biolink:IndividualOrganism", + "subject_category": "biolink:NucleicAcidEntity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "NCBIGene:1806", + "subject_id": "UMLS:C0012872", + "object_id": "NCBIGene:10524", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201571", - "object_id": "NCBIGene:914", + "subject_id": "UMLS:C0233929", + "object_id": "UMLS:C0002996", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2367706", - "object_id": "NCBIGene:5222", + "subject_id": "PUBCHEM.COMPOUND:11597698", + "object_id": "NCBIGene:6530", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "expression" } ] }, @@ -14117,34 +13539,34 @@ "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0006486", - "object_id": "NCBIGene:9528", + "subject_id": "REACT:R-HSA-9796300", + "object_id": "NCBIGene:3170", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "upregulated" } ] }, { "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:Gene", - "predicate": "biolink:affects", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108712", - "object_id": "NCBIGene:3124", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108287", + "object_id": "NCBIGene:5578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "expression" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Gene", - "predicate": "biolink:affects", - "subject_id": "PUBCHEM.COMPOUND:10229498", - "object_id": "NCBIGene:5468", + "predicate": "biolink:causes", + "subject_id": "UBERON:0014374", + "object_id": "NCBIGene:6005", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14153,11 +13575,11 @@ ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:Procedure", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UBERON:0002481", - "object_id": "NCBIGene:5290", + "subject_id": "UMLS:C0017191", + "object_id": "NCBIGene:56477", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14166,119 +13588,54 @@ ] }, { - "subject_category": "biolink:PathologicalProcess", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "NCBIGene:10642", + "subject_id": "PUBCHEM.COMPOUND:24529", + "object_id": "NCBIGene:3043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "molecular_modification" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:IndividualOrganism", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11597698", - "object_id": "NCBIGene:6530", + "subject_id": "UMLS:C0677040", + "object_id": "NCBIGene:1026", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1511997", - "object_id": "NCBIGene:10413", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "CHEBI:60027", - "object_id": "NCBIGene:3757", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "NCBIGene:10524", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Disease", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "MONDO:0008000", - "object_id": "NCBIGene:114548", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108287", - "object_id": "NCBIGene:5578", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" - } - ] - }, - { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0369078", - "object_id": "NCBIGene:5688", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2367706", + "object_id": "NCBIGene:5222", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017191", - "object_id": "NCBIGene:56477", + "subject_id": "UMLS:C1511997", + "object_id": "NCBIGene:10413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -14287,76 +13644,63 @@ "object_category": "biolink:Gene", "predicate": "biolink:causes", "subject_id": "UMLS:C0677040", - "object_id": "NCBIGene:1026", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Gene", - "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "NCBIGene:545", + "object_id": "NCBIGene:1806", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Device", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D004967", - "object_id": "UMLS:C0314614", + "subject_id": "UMLS:C0450138", + "object_id": "NCBIGene:7040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Activity", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079686", - "object_id": "NCBIGene:4956", + "subject_id": "UMLS:C0015259", + "object_id": "NCBIGene:7076", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:NamedThing", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0450138", - "object_id": "NCBIGene:7040", + "subject_id": "NCIT:C49019", + "object_id": "NCBIGene:7161", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "NCBIGene:7076", + "subject_id": "PUBCHEM.COMPOUND:45055432", + "object_id": "NCBIGene:87", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "degradation" } ] }, @@ -14364,12 +13708,12 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:45055432", - "object_id": "NCBIGene:87", + "subject_id": "PUBCHEM.COMPOUND:3450", + "object_id": "NCBIGene:1129", "qualifiers": [ { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "decreased" } ] }, @@ -14382,46 +13726,46 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Gene", + "subject_category": "biolink:Protein", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:24529", - "object_id": "NCBIGene:3043", + "subject_id": "UMLS:C0000392", + "object_id": "UMLS:C2697657", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "molecular_modification" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "NCBIGene:7161", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3976780", + "object_id": "UMLS:C1709820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000392", - "object_id": "UMLS:C2697657", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -14439,11 +13783,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C1705982", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C1709820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14460,7 +13804,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -14468,8 +13812,8 @@ "subject_category": "biolink:Cell", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C3540595", + "subject_id": "UMLS:C0001280", + "object_id": "UMLS:C4049611", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14478,11 +13822,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C3890009", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C1709820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14494,8 +13838,8 @@ "subject_category": "biolink:MolecularMixture", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10339178", - "object_id": "UMLS:C0002085", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C1709820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14504,11 +13848,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Drug", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C3890397", + "subject_id": "UMLS:C0001645", + "object_id": "UMLS:C4284302", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14517,37 +13861,37 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001645", - "object_id": "UMLS:C4284302", + "subject_id": "UMLS:C0079686", + "object_id": "NCBIGene:4956", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Pathway", + "subject_category": "biolink:BiologicalProcess", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0034162", - "object_id": "NCBIGene:57724", + "subject_id": "GO:0006486", + "object_id": "NCBIGene:9528", "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:Pathway", "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "GO:0036414", - "object_id": "NCBIGene:23569", + "subject_id": "GO:0034162", + "object_id": "NCBIGene:57724", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14568,6 +13912,19 @@ } ] }, + { + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Gene", + "predicate": "biolink:causes", + "subject_id": "PUBCHEM.COMPOUND:4621", + "object_id": "NCBIGene:2520", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "synthesis" + } + ] + }, { "subject_category": "biolink:Pathway", "object_category": "biolink:Gene", @@ -14582,63 +13939,63 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Publication", + "object_category": "biolink:Gene", "predicate": "biolink:causes", - "subject_id": "MESH:D000073893", - "object_id": "UMLS:C0205082", + "subject_id": "UMLS:C1301821", + "object_id": "NCBIGene:2168", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:C020650", - "object_id": "UMLS:C0033213", + "subject_id": "UMLS:C0221928", + "object_id": "MONDO:0002406", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100288687", - "object_id": "UMLS:C0205160", + "subject_id": "MESH:D000086942", + "object_id": "MONDO:0006485", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Gene", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C0205161", + "subject_id": "NCBIGene:23405", + "object_id": "UMLS:C1552216", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Drug", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:23706212", - "object_id": "UMLS:C0205082", + "subject_id": "UMLS:C0001640", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14647,24 +14004,24 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:1119", - "object_id": "UMLS:C0205160", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C1142499", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MESH:D000470", - "object_id": "UMLS:C0205161", + "subject_id": "MESH:D002186", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14673,24 +14030,24 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0887909", - "object_id": "UMLS:C0205082", + "subject_id": "MESH:D008925", + "object_id": "MONDO:0002406", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0030956", - "object_id": "UMLS:C0033213", + "subject_id": "UMLS:C0699251", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14699,11 +14056,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003209", - "object_id": "UMLS:C0205160", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0035028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14712,50 +14069,50 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:129651137", - "object_id": "UMLS:C0205082", + "subject_id": "UMLS:C0035007", + "object_id": "UMLS:C0035953", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "NCBIGene:2168", + "subject_id": "UBERON:0000045", + "object_id": "UMLS:C0649526", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Procedure", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001271", - "object_id": "UMLS:C0040669", + "subject_id": "UBERON:0000923", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Procedure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0017654", + "subject_id": "PUBCHEM.COMPOUND:10339178", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14764,11 +14121,11 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0001884", + "subject_id": "HP:0030365", + "object_id": "UMLS:C0022400", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14777,141 +14134,141 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:C040286", - "object_id": "UMLS:C0040669", + "subject_id": "MESH:C000599478", + "object_id": "UMLS:C0205161", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Drug", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0001884", + "subject_id": "UMLS:C0003402", + "object_id": "UMLS:C0205161", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Disease", + "subject_category": "biolink:Gene", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0240035", - "object_id": "MONDO:0000490", + "subject_id": "NCBIGene:100288687", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Disease", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0041904", - "object_id": "UMLS:C0162735", + "subject_id": "PUBCHEM.COMPOUND:10214", + "object_id": "UMLS:C1299586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1295823", - "object_id": "HP:0032326", + "subject_id": "MESH:C585969", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Protein", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0086542", - "object_id": "UMLS:C0199176", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Disease", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "MONDO:0006485", + "subject_id": "CHEMBL.COMPOUND:CHEMBL802", + "object_id": "UMLS:C0184511", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Device", + "subject_category": "biolink:Drug", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16132265", - "object_id": "UMLS:C1553586", + "subject_id": "UMLS:C0003209", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0042018", - "object_id": "UMLS:C0013227", + "subject_id": "NCBIGene:100736251", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Drug", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0003204", + "subject_id": "UMLS:C1704723", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026606", - "object_id": "UMLS:C0849355", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14920,37 +14277,37 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003618", - "object_id": "UMLS:C0039795", + "subject_id": "UMLS:C0073432", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001644", - "object_id": "UMLS:C0807955", + "subject_id": "PUBCHEM.COMPOUND:129651137", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037111", - "object_id": "UMLS:C0806909", + "subject_id": "PUBCHEM.COMPOUND:23667548", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -14959,63 +14316,63 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:C059816", - "object_id": "UMLS:C0806909", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0205160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0178587", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0001884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Protein", - "object_category": "biolink:InformationContentEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002191", - "object_id": "UMLS:C0205254", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "MESH:D005620", - "object_id": "UMLS:C0806909", + "subject_id": "MESH:C040286", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1325", - "object_id": "UMLS:C0807955", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15024,11 +14381,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015528", - "object_id": "UMLS:C0806909", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0001884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15037,24 +14394,24 @@ ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:Drug", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0544461", + "subject_id": "UMLS:C0001644", + "object_id": "UMLS:C0807955", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Food", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0806909", + "subject_id": "MESH:C002502", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15063,37 +14420,37 @@ ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:Protein", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0018407", - "object_id": "UMLS:C0178587", + "subject_id": "UMLS:C0001643", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", + "subject_category": "biolink:ComplexMolecularMixture", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", + "subject_id": "CHEBI:61995", "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Gene", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0152152", - "object_id": "UMLS:C0015915", + "subject_id": "NCBIGene:10010", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15102,37 +14459,37 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000045", - "object_id": "UMLS:C0649526", + "subject_id": "MESH:D005176", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Device", + "subject_category": "biolink:Device", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000923", - "object_id": "UMLS:C0699612", + "subject_id": "UMLS:C0018407", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Activity", + "subject_category": "biolink:Device", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0043084", - "object_id": "UMLS:C0184635", + "subject_id": "UMLS:C0037111", + "object_id": "UMLS:C0806909", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15141,11 +14498,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Activity", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10339178", - "object_id": "UMLS:C0237820", + "subject_id": "MESH:D000080463", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15154,24 +14511,24 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:Disease", + "subject_category": "biolink:Food", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "MONDO:0004992", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0544461", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Food", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006494", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C0007968", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15180,37 +14537,37 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Disease", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "MONDO:0002050", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D015942", - "object_id": "NCIT:C26791", + "subject_id": "UMLS:C0205082", + "object_id": "HP:0045047", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Disease", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "MONDO:0006516", + "subject_id": "UMLS:C0039795", + "object_id": "UMLS:C1286104", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15219,11 +14576,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "MONDO:0002050", + "subject_id": "UMLS:C0042018", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15232,37 +14589,37 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Device", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002932", - "object_id": "UMLS:C0115137", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0003204", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Device", + "subject_category": "biolink:Activity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "UMLS:C0038239", + "subject_id": "UMLS:C0026606", + "object_id": "UMLS:C0849355", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0071500", + "subject_id": "UMLS:C0003618", + "object_id": "UMLS:C0039795", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15271,24 +14628,24 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:Disease", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", - "object_id": "UMLS:C0033086", + "subject_id": "UMLS:C0152152", + "object_id": "UMLS:C0015915", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Device", + "subject_category": "biolink:Gene", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001271", - "object_id": "UMLS:C0071500", + "subject_id": "NCBIGene:114548", + "object_id": "MONDO:0008000", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15297,24 +14654,24 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Device", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026687", - "object_id": "UMLS:C0033086", + "subject_id": "UMLS:C0002788", + "object_id": "MONDO:0700064", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Device", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000240864", - "object_id": "UMLS:C0350056", + "subject_id": "UMLS:C0031715", + "object_id": "MONDO:0020724", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15323,37 +14680,37 @@ ] }, { - "subject_category": "biolink:Cell", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001280", - "object_id": "UMLS:C0649526", + "subject_id": "UMLS:C0001811", + "object_id": "UMLS:C0038239", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001876", - "object_id": "UMLS:C0042838", + "subject_id": "UMLS:C0009393", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:Protein", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0035191", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0071500", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15362,24 +14719,24 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Activity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0035028", + "subject_id": "UMLS:C0001876", + "object_id": "UMLS:C0042838", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Activity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035007", - "object_id": "UMLS:C0035953", + "subject_id": "UMLS:C0002932", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15388,11 +14745,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Procedure", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", - "object_id": "UMLS:C0023690", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0071500", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15401,11 +14758,11 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005612", - "object_id": "UMLS:C0087111", + "subject_id": "UMLS:C0026687", + "object_id": "UMLS:C0033086", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15414,11 +14771,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Disease", + "subject_category": "biolink:Gene", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699251", - "object_id": "MONDO:0002050", + "subject_id": "ENSEMBL:ENSG00000240864", + "object_id": "UMLS:C0350056", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15427,50 +14784,50 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Disease", + "subject_category": "biolink:Cell", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D001428", - "object_id": "MONDO:0041526", + "subject_id": "UMLS:C0001280", + "object_id": "UMLS:C0649526", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:Device", "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "NCBIGene:23405", - "object_id": "UMLS:C1552216", + "subject_id": "UMLS:C0003072", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Procedure", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "CHEBI:75782", - "object_id": "MONDO:0002050", + "subject_id": "UMLS:C0240035", + "object_id": "MONDO:0000490", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Disease", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "MONDO:0002050", + "subject_id": "UMLS:C0887912", + "object_id": "UMLS:C0087111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15479,11 +14836,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Disease", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031715", - "object_id": "MONDO:0020724", + "subject_id": "NCIT:C49019", + "object_id": "UMLS:C0023690", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15492,11 +14849,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Disease", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "NCBIGene:114548", - "object_id": "MONDO:0008000", + "subject_id": "UMLS:C0005612", + "object_id": "UMLS:C0087111", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15505,24 +14862,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Disease", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002788", - "object_id": "MONDO:0700064", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "UMLS:C4552608", - "object_id": "MONDO:0005044", + "subject_id": "UMLS:C0025513", + "object_id": "UMLS:C0394162", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15531,24 +14875,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Behavior", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0009928", + "subject_id": "PUBCHEM.COMPOUND:16132265", + "object_id": "UMLS:C1553586", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:NamedThing", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0966225", - "object_id": "UMLS:C0205082", + "subject_id": "MESH:D000090982", + "object_id": "NCIT:C165206", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15557,37 +14901,37 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "UMLS:C0033213", + "subject_id": "UMLS:C0041904", + "object_id": "UMLS:C0162735", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C1705143", - "object_id": "UMLS:C0205161", + "subject_id": "UMLS:C1295823", + "object_id": "HP:0032326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C3849996", + "subject_id": "UMLS:C4552608", + "object_id": "MONDO:0005044", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15597,10 +14941,10 @@ }, { "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Disease", "predicate": "biolink:causes", "subject_id": "CHEBI:75782", - "object_id": "HP:0004324", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15609,89 +14953,89 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Polypeptide", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0042018", - "object_id": "MONDO:0007016", + "subject_id": "UMLS:C0001413", + "object_id": "MONDO:0002050", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0221928", - "object_id": "MONDO:0002406", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C3849996", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Disease", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0879438", - "object_id": "MONDO:0005070", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Disease", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0350056", - "object_id": "UMLS:C0543419", + "subject_id": "HP:0045047", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0178587", - "object_id": "UMLS:C0543421", + "subject_id": "MESH:D014612", + "object_id": "UMLS:C0033213", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Activity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000211597", - "object_id": "UMLS:C0599946", + "subject_id": "UMLS:C0966225", + "object_id": "UMLS:C0205082", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Activity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10237", - "object_id": "UMLS:C0549255", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0009928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15700,24 +15044,24 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Activity", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001271", - "object_id": "UMLS:C0237820", + "subject_id": "CHEBI:75782", + "object_id": "HP:0004324", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Food", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025513", - "object_id": "UMLS:C0425422", + "subject_id": "UMLS:C0006494", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15726,24 +15070,24 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Behavior", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "UMLS:C0037322", + "subject_id": "UMLS:C0696628", + "object_id": "MONDO:0004992", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:Food", "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013216", - "object_id": "UMLS:C0302295", + "subject_id": "UMLS:C0078479", + "object_id": "MONDO:0006516", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15752,102 +15096,102 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "MONDO:0000088", - "object_id": "UMLS:C0005938", + "subject_id": "UMLS:C0042018", + "object_id": "MONDO:0007016", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Device", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C1101610", - "object_id": "UMLS:C0005938", + "subject_id": "UMLS:C0350056", + "object_id": "UMLS:C0543419", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Cell", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "PUBCHEM.COMPOUND:135499568", + "subject_id": "UMLS:C0879438", + "object_id": "MONDO:0005070", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Procedure", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "ENSEMBL:ENSG00000232543", - "object_id": "UMLS:C0017654", + "subject_id": "UMLS:C0449238", + "object_id": "MONDO:0001576", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Activity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001645", - "object_id": "UMLS:C0001884", + "subject_id": "UMLS:C0015259", + "object_id": "UMLS:C0452415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Device", + "subject_category": "biolink:Protein", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005778", - "object_id": "UMLS:C0035191", + "subject_id": "UMLS:C0001271", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0238711", - "object_id": "UMLS:C0242402", + "subject_id": "ENSEMBL:ENSG00000211597", + "object_id": "UMLS:C0599946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C0871470", + "subject_id": "PUBCHEM.COMPOUND:10237", + "object_id": "UMLS:C0549255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15856,24 +15200,24 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0027950", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0025513", + "object_id": "UMLS:C0425422", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2357", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0016323", + "object_id": "UMLS:C0008071", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15882,89 +15226,89 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699251", - "object_id": "UMLS:C1115729", + "subject_id": "UMLS:C0004268", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0012171", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Protein", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011228", - "object_id": "UMLS:C0079686", + "subject_id": "MESH:D002462", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0000248", - "object_id": "UMLS:C0011313", + "subject_id": "HP:0004324", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Drug", + "subject_category": "biolink:Drug", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "UMLS:C0002763", + "subject_id": "UMLS:C0003402", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:OrganismTaxon", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "HP:0032326", - "object_id": "UMLS:C1295823", + "subject_id": "HP:0001945", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Gene", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10680", - "object_id": "UMLS:C0318759", + "subject_id": "NCBIGene:1302", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -15973,37 +15317,37 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:119374", - "object_id": "UMLS:C1443209", + "subject_id": "UMLS:C0006104", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MONDO:0000448", - "object_id": "UMLS:C0162326", + "subject_id": "UBERON:0000043", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Activity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000254", - "object_id": "UMLS:C0549255", + "subject_id": "CHEMBL.COMPOUND:CHEMBL783", + "object_id": "CHEBI:60027", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16012,24 +15356,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Cell", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0549255", + "subject_id": "UMLS:C0016030", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Activity", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2043", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0002716", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16039,75 +15383,75 @@ }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Publication", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011065", - "object_id": "UMLS:C0033081", + "subject_id": "UMLS:C0007577", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001563", - "object_id": "UMLS:C1510470", + "subject_id": "MONDO:0024331", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "UMLS:C0033213", + "subject_id": "MESH:C009907", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "UMLS:C0205161", + "subject_id": "UMLS:C0017262", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Activity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MESH:C437387", - "object_id": "UMLS:C0008813", + "subject_id": "UMLS:C0237820", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Disease", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001641", - "object_id": "UMLS:C0017654", + "subject_id": "MONDO:0002050", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16116,50 +15460,50 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "MESH:D013256", + "subject_id": "PUBCHEM.COMPOUND:175586", + "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0074339", - "object_id": "UMLS:C0007165", + "subject_id": "UMLS:C0017654", + "object_id": "CHEBI:75782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0543421", - "object_id": "UMLS:C0007165", + "subject_id": "UMLS:C0243102", + "object_id": "CHEBI:60027", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0013216", + "object_id": "UMLS:C0302295", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16168,11 +15512,11 @@ ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "MESH:D010578", + "subject_id": "NCBIGene:2489", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16181,37 +15525,37 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699251", - "object_id": "CHEBI:61995", + "subject_id": "UMLS:C0054889", + "object_id": "UMLS:C0518031", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "NCBIGene:11", - "object_id": "UMLS:C0313560", + "subject_id": "UMLS:C0452415", + "object_id": "UMLS:C0700219", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0279023", - "object_id": "UMLS:C1510470", + "subject_id": "UMLS:C0035028", + "object_id": "UMLS:C0700219", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16220,11 +15564,11 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Procedure", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C0017654", + "subject_id": "UMLS:C0233929", + "object_id": "UMLS:C0452415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16233,11 +15577,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Behavior", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D002186", - "object_id": "UMLS:C0017191", + "subject_id": "UMLS:C0700219", + "object_id": "UMLS:C0452415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16246,24 +15590,24 @@ ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Publication", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C1301821", + "object_id": "MESH:D013256", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "CHEBI:75782", - "object_id": "UMLS:C0017654", + "subject_id": "HP:0001824", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16272,11 +15616,11 @@ ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Procedure", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:472", - "object_id": "UMLS:C0017654", + "subject_id": "MESH:D015942", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16285,23 +15629,23 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Procedure", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0597423", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Device", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2489", + "subject_id": "UMLS:C0003072", "object_id": "UMLS:C0597423", "qualifiers": [ { @@ -16311,11 +15655,11 @@ ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Food", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "MESH:D015942", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0003402", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16324,63 +15668,63 @@ ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Food", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0012171", + "subject_id": "CHEBI:60160", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Food", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MESH:D002462", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0015919", + "object_id": "NCIT:C35041", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Food", + "subject_category": "biolink:Event", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004268", - "object_id": "UMLS:C0078479", + "subject_id": "UMLS:C0681792", + "object_id": "PUBCHEM.COMPOUND:24857", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0043085", + "object_id": "UMLS:C0206217", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Food", + "subject_category": "biolink:Procedure", + "object_category": "biolink:OrganismAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003072", - "object_id": "UMLS:C0597423", + "subject_id": "UMLS:C0087111", + "object_id": "UMLS:C0005612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16389,11 +15733,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Activity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0302295", - "object_id": "UMLS:C0150141", + "subject_id": "UMLS:C0318759", + "object_id": "UMLS:C0003280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16403,88 +15747,88 @@ }, { "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PR:000006102", - "object_id": "PUBCHEM.COMPOUND:15893898", + "subject_id": "UMLS:C0000254", + "object_id": "UMLS:C0549255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Gene", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0021228", + "subject_id": "NCBIGene:2043", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Device", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "UMLS:C0649526", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0549255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Device", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0035191", + "subject_id": "HP:0001518", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Device", + "subject_category": "biolink:Disease", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "MESH:D021982", - "object_id": "UMLS:C0032616", + "subject_id": "MONDO:0000088", + "object_id": "UMLS:C0005938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Device", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "HP:0001824", - "object_id": "UMLS:C0115137", + "subject_id": "UMLS:C1101610", + "object_id": "UMLS:C0005938", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:Cohort", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0115137", + "subject_id": "UMLS:C0338666", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16494,49 +15838,49 @@ }, { "subject_category": "biolink:NamedThing", - "object_category": "biolink:Device", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015528", - "object_id": "UMLS:C0115137", + "subject_id": "NCIT:C49019", + "object_id": "UMLS:C0013227", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Device", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017262", - "object_id": "UMLS:C0032616", + "subject_id": "UMLS:C0031911", + "object_id": "UMLS:C0003448", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Device", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032942", - "object_id": "UMLS:C0115137", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "NCBIGene:117189", - "object_id": "UMLS:C0074530", + "subject_id": "UMLS:C0011065", + "object_id": "UMLS:C0033081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16545,128 +15889,128 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Disease", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0521974", - "object_id": "UMLS:C0543421", + "subject_id": "MONDO:0000490", + "object_id": "UMLS:C0240035", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Device", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "UMLS:C0543421", + "subject_id": "UMLS:C0032616", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0543421", + "subject_id": "MESH:C022699", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCIT:C35041", + "subject_id": "MESH:D000073893", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "GO:0018101", - "object_id": "MESH:D000076342", + "subject_id": "UMLS:C0005482", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "UMLS:C0237820", + "subject_id": "PUBCHEM.COMPOUND:16216920", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1222251", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0006660", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Activity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0018563", + "object_id": "UMLS:C0037392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Activity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000080463", - "object_id": "UMLS:C1832073", + "subject_id": "MESH:D010578", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Drug", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "NCBITaxon:11089", + "subject_id": "UMLS:C0003280", + "object_id": "UMLS:C0037392", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16675,180 +16019,180 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "UMLS:C0600465", + "subject_id": "NCIT:C35041", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Drug", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "MESH:D000088502", - "object_id": "UMLS:C0033607", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0597697", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:Drug", + "subject_category": "biolink:Publication", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031911", - "object_id": "UMLS:C0003448", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0005495", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Drug", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "CHEBI:60160", - "object_id": "UMLS:C0013227", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "NCIT:C49019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cohort", - "object_category": "biolink:Drug", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0338666", - "object_id": "UMLS:C0013227", + "subject_id": "DrugCentral:5441", + "object_id": "UniProtKB:P49674", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:453626", - "object_id": "PUBCHEM.COMPOUND:130074", + "subject_id": "CHEMBL.COMPOUND:CHEMBL4297981", + "object_id": "UniProtKB:P01857", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012929", - "object_id": "UMLS:C1440070", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0012934", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0021498", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0034917", + "object_id": "UMLS:C0037322", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D013205", - "object_id": "UMLS:C0178587", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0350056", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Publication", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2168", - "object_id": "UMLS:C1301821", + "subject_id": "UMLS:C0015259", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Publication", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0166415", - "object_id": "UMLS:C1301821", + "subject_id": "UMLS:C0025513", + "object_id": "UMLS:C0279023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Publication", + "subject_category": "biolink:Activity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:D013256", - "object_id": "UMLS:C1301821", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Publication", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002763", - "object_id": "UMLS:C1301821", + "subject_id": "UMLS:C0005778", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MESH:C431888", - "object_id": "UMLS:C1517336", + "subject_id": "UMLS:C0023823", + "object_id": "UMLS:C0035191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -16857,206 +16201,206 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Cell", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020964", - "object_id": "UMLS:C0879438", + "subject_id": "UMLS:C0017262", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002520", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0013081", + "object_id": "UMLS:C0649526", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Activity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001272", - "object_id": "UMLS:C0599946", + "subject_id": "NCBIGene:117189", + "object_id": "UMLS:C0074530", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100528023", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0019868", + "object_id": "UMLS:C0035028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalMixture", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "UMLS:C0599946", + "subject_id": "UMLS:C0021498", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Device", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0233929", + "object_id": "UMLS:C0035028", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Activity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C0237820", + "subject_id": "MESH:C002502", + "object_id": "NCBIGene:317782", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0237820", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Activity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001413", - "object_id": "UMLS:C0237820", + "subject_id": "MESH:C431888", + "object_id": "UMLS:C1517336", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Cell", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013081", - "object_id": "UMLS:C0599946", + "subject_id": "UMLS:C0003315", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Activity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011313", - "object_id": "UMLS:C0599946", + "subject_id": "HP:0000718", + "object_id": "NCBIGene:4963", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Activity", + "subject_category": "biolink:Disease", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037732", - "object_id": "UMLS:C0599946", + "subject_id": "MONDO:0000448", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024432", - "object_id": "UMLS:C0369078", + "subject_id": "UMLS:C0002074", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:5688", - "object_id": "UMLS:C0369078", + "subject_id": "UBERON:0000119", + "object_id": "UMLS:C3178810", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:Behavior", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16162108", - "object_id": "UMLS:C0376180", + "subject_id": "UMLS:C0003646", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL783", - "object_id": "CHEBI:60027", + "subject_id": "UMLS:C0001390", + "object_id": "NCBIGene:252842", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17065,76 +16409,76 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "HP:0004324", - "object_id": "CHEBI:75782", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002716", - "object_id": "CHEBI:75782", + "subject_id": "UMLS:C0003314", + "object_id": "UMLS:C1512886", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalMixture", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007577", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0000934", + "object_id": "UMLS:C0080089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "HP:0001945", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0009393", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0024331", - "object_id": "CHEBI:75782", + "subject_id": "NCBIGene:100188830", + "object_id": "UMLS:C0677504", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C009907", - "object_id": "CHEBI:60160", + "subject_id": "UMLS:C0002085", + "object_id": "NCBIGene:470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17143,24 +16487,24 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Protein", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016030", - "object_id": "CHEBI:61452", + "subject_id": "UMLS:C0011228", + "object_id": "UMLS:C0079686", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017654", - "object_id": "CHEBI:75782", + "subject_id": "CHEBI:61452", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17169,37 +16513,37 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MONDO:0002050", - "object_id": "CHEBI:75782", + "subject_id": "MESH:D021982", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1302", - "object_id": "CHEBI:75782", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0032616", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003402", - "object_id": "CHEBI:75782", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C0038239", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17208,128 +16552,115 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:ChemicalMixture", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "CHEBI:75782", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:CellularComponent", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:175586", + "subject_id": "MESH:D008247", "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Phenomenon", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0243102", + "subject_id": "UMLS:C0005520", "object_id": "CHEBI:60027", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006104", - "object_id": "CHEBI:75782", + "subject_id": "NCBIGene:472", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UBERON:0000043", + "subject_id": "UMLS:C0232407", "object_id": "CHEBI:60160", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GeneticInheritance", + "subject_category": "biolink:Device", "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017262", - "object_id": "CHEBI:75782", + "subject_id": "UMLS:C0032616", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ChemicalMixture", "predicate": "biolink:causes", - "subject_id": "MESH:D053260", - "object_id": "UMLS:C0042834", + "subject_id": "MESH:D010578", + "object_id": "CHEBI:61452", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0720298", - "object_id": "UMLS:C0806069", + "subject_id": "UMLS:C0115137", + "object_id": "UMLS:C0032942", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "UMLS:C0162326", + "subject_id": "MESH:D000088502", + "object_id": "UMLS:C0033607", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "NCBIGene:100188830", - "object_id": "UMLS:C0677504", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17338,89 +16669,89 @@ ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003646", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0001645", + "object_id": "UMLS:C0001884", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "NCBIGene:470", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C1515979", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "HP:0000718", - "object_id": "NCBIGene:4963", + "subject_id": "NCIT:C54685", + "object_id": "UMLS:C1563921", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003314", - "object_id": "UMLS:C1512886", + "subject_id": "ENSEMBL:ENSG00000232543", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C1301821", + "object_id": "UMLS:C0002763", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "LOINC:LP7067-4", - "object_id": "UMLS:C0009221", + "subject_id": "NCBIGene:140821", + "object_id": "UMLS:C1705549", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C002502", - "object_id": "NCBIGene:317782", + "subject_id": "UMLS:C0001038", + "object_id": "UMLS:C1707128", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17429,102 +16760,102 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004793", - "object_id": "UMLS:C0012872", + "subject_id": "UBERON:0000007", + "object_id": "UMLS:C1708431", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000119", - "object_id": "UMLS:C3178810", + "subject_id": "MESH:D000067128", + "object_id": "UMLS:C1705085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", - "object_id": "UMLS:C0162326", + "subject_id": "HP:0000689", + "object_id": "UMLS:C3538714", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Phenomenon", - "object_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002074", - "object_id": "UMLS:C0004793", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C0162327", + "subject_id": "UMLS:C0002345", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008813", - "object_id": "UMLS:C0004793", + "subject_id": "UMLS:C0023775", + "object_id": "UMLS:C1709820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "NCBIGene:470", + "subject_id": "UMLS:C0003808", + "object_id": "UMLS:C3539704", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035191", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17533,11 +16864,11 @@ ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001640", - "object_id": "NCBIGene:6012", + "subject_id": "UMLS:C0012868", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17546,102 +16877,102 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:Cell", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2110581", - "object_id": "PR:000001154", + "subject_id": "UMLS:C0004112", + "object_id": "UMLS:C3813609", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015219", - "object_id": "MESH:D020077", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0678941", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0006556", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "PUBCHEM.COMPOUND:166717", + "subject_id": "UMLS:C0009393", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:InformationContentEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "HP:0100578", - "object_id": "UMLS:C0221928", + "subject_id": "HP:0003651", + "object_id": "UMLS:C1705791", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D007375", - "object_id": "UMLS:C3816499", + "subject_id": "UMLS:C0597423", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10524", - "object_id": "UMLS:C0012872", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:Drug", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "UMLS:C0003402", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0002085", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17650,37 +16981,37 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2103797", - "object_id": "PR:000001154", + "subject_id": "UMLS:C1158013", + "object_id": "UMLS:C0002085", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "UMLS:C0011313", + "subject_id": "CHEBI:61995", + "object_id": "UMLS:C2698933", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Drug", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0011313", - "object_id": "UMLS:C0318761", + "subject_id": "UMLS:C0001641", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17689,24 +17020,24 @@ ] }, { - "subject_category": "biolink:Procedure", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0441650", - "object_id": "UMLS:C0556030", + "subject_id": "MESH:C437387", + "object_id": "UMLS:C0008813", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Activity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019868", - "object_id": "UMLS:C0035028", + "subject_id": "MESH:D002186", + "object_id": "UMLS:C0017191", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17715,11 +17046,11 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Activity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0233929", - "object_id": "UMLS:C0035028", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17728,11 +17059,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C022699", - "object_id": "UMLS:C0015919", + "subject_id": "PR:000006102", + "object_id": "UMLS:C0770882", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "localization" + } + ] + }, + { + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:AnatomicalEntity", + "predicate": "biolink:causes", + "subject_id": "PUBCHEM.COMPOUND:5234", + "object_id": "UMLS:C0042018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17742,10 +17086,10 @@ }, { "subject_category": "biolink:Drug", - "object_category": "biolink:OrganismTaxon", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003280", - "object_id": "UMLS:C0318759", + "subject_id": "UMLS:C0013227", + "object_id": "UMLS:C0042018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17754,24 +17098,24 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "PR:000006102", - "object_id": "UMLS:C0770882", + "subject_id": "MONDO:0007016", + "object_id": "UMLS:C0042018", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0233929", - "object_id": "UMLS:C0849355", + "subject_id": "UMLS:C0597423", + "object_id": "UMLS:C0003072", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17780,167 +17124,167 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001601", - "object_id": "UMLS:C1149593", + "subject_id": "UMLS:C0006556", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Phenomenon", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0043085", - "object_id": "UMLS:C0206217", + "subject_id": "UMLS:C0005495", + "object_id": "UMLS:C0054889", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UBERON:0001048", - "object_id": "UMLS:C0029960", + "subject_id": "UMLS:C0004391", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Drug", + "subject_category": "biolink:Device", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0318759", - "object_id": "UMLS:C0003280", + "subject_id": "UMLS:C0032616", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Behavior", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035028", - "object_id": "UMLS:C0700219", + "subject_id": "UMLS:C0041904", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0442751", + "subject_id": "MESH:D003850", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0205161", + "subject_id": "NCBIGene:57760", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:OrganismTaxon", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C1440605", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0040669", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Event", - "object_category": "biolink:SmallMolecule", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0681792", - "object_id": "PUBCHEM.COMPOUND:24857", + "subject_id": "PR:000006102", + "object_id": "PUBCHEM.COMPOUND:15893898", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Cell", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0452415", - "object_id": "UMLS:C0700219", + "subject_id": "UMLS:C0443611", + "object_id": "UMLS:C0042784", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0233929", - "object_id": "UMLS:C0452415", + "subject_id": "UMLS:C0026687", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "UMLS:C0452415", + "subject_id": "UMLS:C0597295", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0700219", - "object_id": "UMLS:C0452415", + "subject_id": "UMLS:C1115729", + "object_id": "UMLS:C0699251", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17949,11 +17293,11 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:OrganismAttribute", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0087111", - "object_id": "UMLS:C0005612", + "subject_id": "UMLS:C0001390", + "object_id": "CHEBI:61995", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17962,11 +17306,11 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0016323", - "object_id": "UMLS:C0008071", + "subject_id": "MESH:D005176", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17975,11 +17319,11 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Publication", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C1286104", - "object_id": "UMLS:C0039795", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C0001390", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -17988,89 +17332,89 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Procedure", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MONDO:0000490", - "object_id": "UMLS:C0240035", + "subject_id": "UMLS:C0020964", + "object_id": "UMLS:C0919262", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0597697", + "subject_id": "UMLS:C1160534", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Disease", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", - "object_id": "MESH:D055432", + "subject_id": "MONDO:0002050", + "object_id": "UMLS:C0001413", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0035736", + "subject_id": "UMLS:C0042834", + "object_id": "MESH:D053260", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0012934", + "subject_id": "MESH:D053260", + "object_id": "UMLS:C0042834", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Device", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023823", - "object_id": "UMLS:C0035191", + "subject_id": "NCBIGene:2489", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0806909", - "object_id": "UMLS:C0037111", + "subject_id": "PUBCHEM.COMPOUND:10680", + "object_id": "UMLS:C0318759", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18079,141 +17423,141 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0243192", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "UMLS:C0086908", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0006494", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005482", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0543421", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16216920", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0074339", + "object_id": "UMLS:C0007165", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D000073893", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0012872", + "object_id": "UMLS:C0080065", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0018563", - "object_id": "UMLS:C0037392", + "subject_id": "PUBCHEM.COMPOUND:11970143", + "object_id": "UMLS:C0677043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006660", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0017654", + "object_id": "UMLS:C0728977", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Food", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "NCIT:C35041", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C1572543", + "object_id": "NCIT:C49019", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Drug", - "object_category": "biolink:PhysicalEntity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003280", - "object_id": "UMLS:C0037392", + "subject_id": "UMLS:C0002842", + "object_id": "UMLS:C0677043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "MESH:D010578", - "object_id": "UMLS:C0015919", + "subject_id": "NCBIGene:2272", + "object_id": "UMLS:C0677043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0025513", - "object_id": "UMLS:C0279023", + "subject_id": "UMLS:C0001563", + "object_id": "UMLS:C1510470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18222,11 +17566,11 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015259", - "object_id": "UMLS:C0279023", + "subject_id": "MESH:D000071439", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18235,37 +17579,37 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Drug", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005520", - "object_id": "CHEBI:60027", + "subject_id": "UMLS:C0001640", + "object_id": "NCBIGene:6012", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0232407", - "object_id": "CHEBI:60160", + "subject_id": "NCBIGene:4956", + "object_id": "UMLS:C0079686", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Activity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "CHEBI:61452", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0079925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18275,23 +17619,10 @@ }, { "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ChemicalMixture", - "predicate": "biolink:causes", - "subject_id": "MESH:D010578", - "object_id": "CHEBI:61452", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" - } - ] - }, - { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:Device", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "UMLS:C0032616", + "subject_id": "CHEBI:61995", + "object_id": "NCBIGene:470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18300,24 +17631,24 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Device", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0032616", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C0080089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:Device", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0038239", + "subject_id": "UMLS:C0449238", + "object_id": "NCBIGene:140821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18326,132 +17657,128 @@ ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:ChemicalMixture", + "subject_category": "biolink:Procedure", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D021982", - "object_id": "CHEBI:60027", + "subject_id": "UMLS:C0008813", + "object_id": "UMLS:C0004793", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Behavior", + "subject_category": "biolink:Procedure", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0115137", - "object_id": "UMLS:C0032942", + "subject_id": "UMLS:C0004910", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C1515979", + "subject_id": "DRUGBANK:DB09446", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Food", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "NCIT:C54685", - "object_id": "UMLS:C1563921", + "subject_id": "UMLS:C0078479", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "DrugCentral:5441", - "object_id": "UniProtKB:P49674", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0871470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:9852188", - "object_id": "UniProtKB:P24462", + "subject_id": "UMLS:C0023823", + "object_id": "UMLS:C0871470", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:Food", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11319217", - "object_id": "UniProtKB:P12488", + "subject_id": "UMLS:C0037570", + "object_id": "UMLS:C0871470", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Cohort", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0242402", + "object_id": "UMLS:C0338666", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Cohort", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004083", - "object_id": "UMLS:C3539704", + "subject_id": "PUBCHEM.COMPOUND:446220", + "object_id": "UMLS:C0338666", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Cohort", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "UMLS:C1707128", + "subject_id": "UMLS:C0013227", + "object_id": "UMLS:C0338666", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18460,50 +17787,50 @@ ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "HP:0000741", - "object_id": "UMLS:C3811119", + "subject_id": "MONDO:0005594", + "object_id": "UMLS:C0535454", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000007", - "object_id": "UMLS:C1708431", + "subject_id": "UMLS:C0599946", + "object_id": "UMLS:C0013081", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012899", - "object_id": "UMLS:C1705873", + "subject_id": "UMLS:C0002165", + "object_id": "UMLS:C0150479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:Device", "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012868", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0699612", + "object_id": "UMLS:C0017346", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18512,102 +17839,102 @@ ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Procedure", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:470", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0040669", + "object_id": "UMLS:C0041904", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "MESH:D000067128", - "object_id": "UMLS:C2825955", + "subject_id": "MONDO:0004609", + "object_id": "UMLS:C1515672", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004112", - "object_id": "UMLS:C3813609", + "subject_id": "PUBCHEM.COMPOUND:119374", + "object_id": "UMLS:C1443209", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023775", - "object_id": "UMLS:C1709820", + "subject_id": "UMLS:C5202641", + "object_id": "UMLS:C0004268", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003261", - "object_id": "UMLS:C0002085", + "subject_id": "MESH:D000090982", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:AnatomicalEntity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000044", - "object_id": "UMLS:C3889133", + "subject_id": "UMLS:C0035191", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Cell", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0003315", + "object_id": "NCBIGene:84565", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0002085", + "subject_id": "MESH:D020077", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18616,76 +17943,76 @@ ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C1167395", + "object_id": "UMLS:C0162326", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Activity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1158013", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0237820", + "object_id": "NCBIGene:100528023", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:GenomicEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0007165", + "object_id": "NCBIGene:5120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0020969", + "object_id": "UMLS:C0162327", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0009393", - "object_id": "UMLS:C0002085", + "subject_id": "UMLS:C0004793", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:Disease", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "HP:0003651", - "object_id": "UMLS:C1705791", + "subject_id": "UMLS:C0302295", + "object_id": "UMLS:C0150141", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18694,11 +18021,11 @@ ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C2698933", + "subject_id": "UMLS:C1705280", + "object_id": "UBERON:0014374", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18707,11 +18034,11 @@ ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:Device", + "subject_category": "biolink:Gene", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "UMLS:C0003072", + "subject_id": "NCBIGene:5688", + "object_id": "UMLS:C0369078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18720,128 +18047,128 @@ ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Procedure", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005495", - "object_id": "UMLS:C0054889", + "subject_id": "MESH:D014612", + "object_id": "NCBITaxon:11089", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0041904", - "object_id": "UMLS:C0040669", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C0600465", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Procedure", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004391", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0006147", + "object_id": "UMLS:C1137094", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "NCBIGene:57760", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0012931", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Procedure", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0032616", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0677043", + "object_id": "UMLS:C0012939", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Procedure", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0040669", + "subject_id": "UMLS:C0677040", + "object_id": "UMLS:C0006556", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:Activity", + "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0443611", - "object_id": "UMLS:C0042784", + "subject_id": "UMLS:C0237820", + "object_id": "UMLS:C0185624", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", + "subject_category": "biolink:Protein", "object_category": "biolink:NamedThing", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597295", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0010654", + "object_id": "UMLS:C0677043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "CHEBI:61995", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C3827014", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhysicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1115729", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0015919", + "object_id": "NCBIGene:8066", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18850,24 +18177,24 @@ ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0026687", - "object_id": "UMLS:C0699251", + "subject_id": "UMLS:C0001038", + "object_id": "NCBIGene:1257", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "UMLS:C0042018", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18876,11 +18203,11 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:5234", - "object_id": "UMLS:C0042018", + "subject_id": "UMLS:C0017346", + "object_id": "UMLS:C0699612", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18889,89 +18216,89 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MONDO:0007016", - "object_id": "UMLS:C0042018", + "subject_id": "UMLS:C0032942", + "object_id": "UMLS:C0115137", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "MONDO:0002050", - "object_id": "UMLS:C0001413", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0074339", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020964", - "object_id": "UMLS:C0919262", + "subject_id": "UMLS:C0599177", + "object_id": "UMLS:C0019054", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C1160534", - "object_id": "UMLS:C0001413", + "subject_id": "PUBCHEM.COMPOUND:16057918", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0042834", - "object_id": "MESH:D053260", + "subject_id": "NCBIGene:10777", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:IndividualOrganism", - "object_category": "biolink:Drug", + "subject_category": "biolink:Disease", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0677040", - "object_id": "UMLS:C0243192", + "subject_id": "MONDO:0005271", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:Food", + "subject_category": "biolink:Protein", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0006494", + "subject_id": "UMLS:C0002520", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -18980,154 +18307,154 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023690", - "object_id": "MESH:D055432", + "subject_id": "UMLS:C0243102", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:1057", - "object_id": "UMLS:C1151664", + "subject_id": "NCBIGene:8066", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:InformationContentEntity", + "object_category": "biolink:PhysicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1572543", - "object_id": "MESH:D055432", + "subject_id": "UMLS:C0449238", + "object_id": "UMLS:C0015919", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002842", - "object_id": "UMLS:C0677043", + "subject_id": "UMLS:C0023754", + "object_id": "UMLS:C0521974", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Phenomenon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:2272", - "object_id": "UMLS:C0677043", + "subject_id": "UMLS:C0008071", + "object_id": "UMLS:C0016323", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000071439", - "object_id": "UMLS:C0162326", + "subject_id": "MESH:D007375", + "object_id": "UMLS:C3816499", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Protein", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MESH:C496540", - "object_id": "UMLS:C0079686", - "qualifiers": [ + "subject_id": "UMLS:C0080065", + "object_id": "UMLS:C0012872", + "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Gene", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0079925", + "subject_id": "NCBIGene:10524", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0012872", - "object_id": "UMLS:C0080065", + "subject_id": "PUBCHEM.COMPOUND:44135672", + "object_id": "UMLS:C0012872", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Cohort", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:446220", - "object_id": "UMLS:C0338666", + "subject_id": "CHEBI:75782", + "object_id": "UMLS:C0017654", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Cohort", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0242402", - "object_id": "UMLS:C0338666", + "subject_id": "HP:0045047", + "object_id": "NCBIGene:619511", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Cohort", + "subject_category": "biolink:Food", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013227", - "object_id": "UMLS:C0338666", + "subject_id": "UMLS:C0597423", + "object_id": "NCBIGene:2489", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19136,11 +18463,11 @@ ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Device", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0005594", - "object_id": "UMLS:C0535454", + "subject_id": "MESH:D016753", + "object_id": "NCBIGene:1218", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19149,76 +18476,76 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004910", - "object_id": "UMLS:C0871470", + "subject_id": "UBERON:0000948", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:Cell", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "DRUGBANK:DB09446", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0004561", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismAttribute", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0020969", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0078479", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0015219", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Food", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0037570", - "object_id": "UMLS:C0871470", + "subject_id": "UMLS:C0162326", + "object_id": "MESH:D020077", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:ClinicalAttribute", + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023823", - "object_id": "UMLS:C0871470", + "subject_id": "MESH:D008925", + "object_id": "UMLS:C1099354", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19227,206 +18554,206 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080129", - "object_id": "UMLS:C0013081", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C0061928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0599946", - "object_id": "UMLS:C0013081", + "subject_id": "UMLS:C1515508", + "object_id": "UMLS:C0600680", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:IndividualOrganism", + "object_category": "biolink:SmallMolecule", "predicate": "biolink:causes", - "subject_id": "MESH:C024211", - "object_id": "UMLS:C0004366", + "subject_id": "UMLS:C0677040", + "object_id": "PUBCHEM.COMPOUND:166717", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:ChemicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008546", - "object_id": "UMLS:C0004366", + "subject_id": "UMLS:C0696628", + "object_id": "MESH:C110027", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10642", - "object_id": "UMLS:C0004366", + "subject_id": "UMLS:C1099354", + "object_id": "MESH:D008925", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:Publication", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "UMLS:C0004366", + "subject_id": "UMLS:C1301821", + "object_id": "UMLS:C0166415", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", - "object_id": "UMLS:C0004366", + "subject_id": "UMLS:C0002198", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PathologicalProcess", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10964", - "object_id": "UMLS:C0004366", + "subject_id": "PUBCHEM.COMPOUND:130074", + "object_id": "PUBCHEM.COMPOUND:453626", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:135499568", - "object_id": "UMLS:C0004366", + "subject_id": "CHEMBL.COMPOUND:CHEMBL4650316", + "object_id": "UMLS:C0665341", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PathologicalProcess", + "subject_category": "biolink:Gene", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "UMLS:C0004366", + "subject_id": "NCBIGene:10413", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0699612", - "object_id": "UMLS:C0017346", + "subject_id": "MESH:C098215", + "object_id": "UMLS:C1521889", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040669", - "object_id": "UMLS:C0041904", + "subject_id": "PUBCHEM.COMPOUND:10836", + "object_id": "UMLS:C0238711", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "MONDO:0004609", - "object_id": "UMLS:C1515672", + "subject_id": "PUBCHEM.COMPOUND:16131300", + "object_id": "UMLS:C0240321", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C0752046", + "subject_id": "MESH:D008076", + "object_id": "UMLS:C0240321", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003315", - "object_id": "NCBIGene:84565", + "subject_id": "UMLS:C0005938", + "object_id": "UMLS:C1101610", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "MESH:D003850", - "object_id": "NCBIGene:7896", + "subject_id": "UMLS:C0001811", + "object_id": "NCBITaxon:5315", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19435,24 +18762,24 @@ ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:PhysiologicalProcess", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "NCBIGene:100528023", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0598958", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "MESH:D020077", - "object_id": "UMLS:C0162326", + "subject_id": "UMLS:C0001451", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19461,89 +18788,89 @@ ] }, { - "subject_category": "biolink:PathologicalProcess", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004366", - "object_id": "UMLS:C0162326", + "subject_id": "MESH:C020093", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "NCBIGene:5120", + "subject_id": "PUBCHEM.COMPOUND:107838", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Gene", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C1167395", - "object_id": "UMLS:C0162326", + "subject_id": "NCBIGene:10013", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "UMLS:C0162327", + "subject_id": "UMLS:C0678607", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Food", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017127", - "object_id": "UMLS:C0078479", + "subject_id": "UMLS:C0005495", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Behavior", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006147", - "object_id": "UMLS:C1137094", + "subject_id": "UMLS:C0004391", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:InformationContentEntity", - "object_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0039795", - "object_id": "UMLS:C1286104", + "subject_id": "NCBIGene:57762", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19552,67 +18879,24 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Disease", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL4297981", - "object_id": "UniProtKB:P01857", + "subject_id": "UMLS:C1140999", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", "qualifier_value": "activity_or_abundance" - }, - { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0012931", - "object_id": "UMLS:C1511997", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0677043", - "object_id": "UMLS:C0012939", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Cell", - "object_category": "biolink:NamedThing", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0039194", - "object_id": "UMLS:C1178562", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:Activity", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0237820", - "object_id": "UMLS:C0185624", + "subject_id": "PUBCHEM.COMPOUND:5310940", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19621,24 +18905,11 @@ ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:Polypeptide", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C3827014", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Drug", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "NCBIGene:8066", + "subject_id": "UMLS:C0003286", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19647,11 +18918,11 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001038", - "object_id": "NCBIGene:1257", + "subject_id": "UMLS:C0001390", + "object_id": "UMLS:C0599740", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19660,11 +18931,11 @@ ] }, { - "subject_category": "biolink:GenomicEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "UMLS:C0017346", - "object_id": "UMLS:C0699612", + "subject_id": "CHEBI:61452", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19673,76 +18944,50 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", + "subject_category": "biolink:PhysicalEntity", "object_category": "biolink:ComplexMolecularMixture", "predicate": "biolink:causes", - "subject_id": "GO:0006342", - "object_id": "MESH:D007459", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Device", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0007165", - "object_id": "UMLS:C0074339", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Disease", - "predicate": "biolink:causes", - "subject_id": "UMLS:C0599177", - "object_id": "UMLS:C0019054", + "subject_id": "UMLS:C0015919", + "object_id": "MESH:D010578", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Behavior", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16057918", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C1331418", + "object_id": "UMLS:C0054889", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:GrossAnatomicalStructure", "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C0023754", - "object_id": "UMLS:C0521974", + "subject_id": "UBERON:0001384", + "object_id": "UMLS:C0032042", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10777", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0031715", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19752,36 +18997,23 @@ }, { "subject_category": "biolink:Disease", - "object_category": "biolink:PhysicalEntity", - "predicate": "biolink:causes", - "subject_id": "MONDO:0005271", - "object_id": "UMLS:C0015919", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:PhysicalEntity", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0243102", - "object_id": "UMLS:C0015919", + "subject_id": "MONDO:0006516", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:PhysicalEntity", + "subject_category": "biolink:Cell", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "NCBIGene:8066", - "object_id": "UMLS:C0015919", + "subject_id": "UMLS:C0024432", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19790,11 +19022,11 @@ ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:Phenomenon", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "UMLS:C0008071", - "object_id": "UMLS:C0016323", + "subject_id": "UMLS:C0871470", + "object_id": "UMLS:C0078479", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19803,141 +19035,141 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0080065", - "object_id": "UMLS:C0012872", + "subject_id": "HP:0000752", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:44135672", - "object_id": "UMLS:C0012872", + "subject_id": "MESH:D013205", + "object_id": "UMLS:C0178587", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "MESH:D020077", + "subject_id": "CHEMBL.COMPOUND:CHEMBL517712", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismAttribute", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0020969", - "object_id": "MESH:D020077", + "subject_id": "MESH:D014357", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:Drug", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000948", - "object_id": "MESH:D020077", + "subject_id": "UMLS:C0001640", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NucleicAcidEntity", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0162326", - "object_id": "MESH:D020077", + "subject_id": "MESH:D000080463", + "object_id": "UMLS:C1832073", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "HP:0045047", - "object_id": "NCBIGene:619511", + "subject_id": "UMLS:C0035191", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:NucleicAcidEntity", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "NCBIGene:1218", + "subject_id": "MESH:D000086942", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:Food", - "object_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0597423", - "object_id": "NCBIGene:2489", + "subject_id": "UMLS:C0037732", + "object_id": "UMLS:C0599946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "UMLS:C0061928", + "subject_id": "UMLS:C0001413", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Drug", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515508", - "object_id": "UMLS:C0600680", + "subject_id": "UMLS:C0001641", + "object_id": "UMLS:C0549255", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19946,11 +19178,11 @@ ] }, { - "subject_category": "biolink:PopulationOfIndividualOrganisms", - "object_category": "biolink:ChemicalEntity", + "subject_category": "biolink:Device", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0696628", - "object_id": "MESH:C110027", + "subject_id": "UMLS:C0182473", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -19959,115 +19191,102 @@ ] }, { - "subject_category": "biolink:Publication", - "object_category": "biolink:Protein", - "predicate": "biolink:causes", - "subject_id": "UMLS:C1301821", - "object_id": "UMLS:C0166415", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL4650316", - "object_id": "UMLS:C0665341", + "subject_id": "NCBIGene:100528023", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:130074", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C0079925", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002198", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "UMLS:C0185624", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:ChemicalMixture", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "NCBIGene:545", - "object_id": "PUBCHEM.COMPOUND:453626", + "subject_id": "CHEBI:61452", + "object_id": "UMLS:C0599946", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:Activity", "predicate": "biolink:causes", - "subject_id": "MESH:C098215", - "object_id": "UMLS:C1521889", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0237820", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Gene", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Protein", + "object_category": "biolink:MolecularMixture", "predicate": "biolink:causes", - "subject_id": "NCBIGene:10413", - "object_id": "UMLS:C1511997", + "subject_id": "CHEMBL.TARGET:CHEMBL2179", + "object_id": "PUBCHEM.COMPOUND:70697642", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "stability" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005938", - "object_id": "UMLS:C1101610", + "subject_id": "UMLS:C0033213", + "object_id": "UMLS:C1704723", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", - "object_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:GeneFamily", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001811", - "object_id": "NCBITaxon:5315", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1200395", + "object_id": "CHEMBL.TARGET:CHEMBL2331043", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20076,11 +19295,11 @@ ] }, { - "subject_category": "biolink:BiologicalEntity", - "object_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0085295", - "object_id": "UMLS:C0598958", + "subject_id": "UMLS:C0233929", + "object_id": "UMLS:C0849355", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20089,180 +19308,180 @@ ] }, { - "subject_category": "biolink:ChemicalMixture", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:Gene", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "CHEBI:61452", - "object_id": "MESH:D010578", + "subject_id": "NCBIGene:2168", + "object_id": "UMLS:C1301821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhysicalEntity", - "object_category": "biolink:ComplexMolecularMixture", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C0015919", - "object_id": "MESH:D010578", + "subject_id": "MESH:D013256", + "object_id": "UMLS:C1301821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Behavior", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Protein", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UMLS:C1331418", - "object_id": "UMLS:C0054889", + "subject_id": "UMLS:C0166415", + "object_id": "UMLS:C1301821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:Procedure", + "subject_category": "biolink:Drug", + "object_category": "biolink:Publication", "predicate": "biolink:causes", - "subject_id": "UBERON:0001384", - "object_id": "UMLS:C0032042", + "subject_id": "UMLS:C0002763", + "object_id": "UMLS:C1301821", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:Food", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "MONDO:0006516", - "object_id": "UMLS:C0078479", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1481", + "object_id": "PR:000006120", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:Food", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0024432", - "object_id": "UMLS:C0078479", + "subject_id": "MESH:D000438", + "object_id": "PR:000006122", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Food", + "subject_category": "biolink:Drug", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0031715", - "object_id": "UMLS:C0078479", + "subject_id": "NCIT:C116928", + "object_id": "PR:000006130", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:ClinicalAttribute", - "object_category": "biolink:Food", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C0871470", - "object_id": "UMLS:C0078479", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", + "object_id": "PR:000006130", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:Activity", + "subject_category": "biolink:Protein", + "object_category": "biolink:Drug", "predicate": "biolink:causes", - "subject_id": "UMLS:C0185624", - "object_id": "UMLS:C0237820", + "subject_id": "PR:000006102", + "object_id": "UMLS:C2684108", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "localization" } ] }, { - "subject_category": "biolink:Device", - "object_category": "biolink:Activity", + "subject_category": "biolink:Disease", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0182473", - "object_id": "UMLS:C0237820", + "subject_id": "MONDO:0001627", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Activity", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0001641", - "object_id": "UMLS:C0549255", + "subject_id": "UMLS:C0003261", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:Activity", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000086942", - "object_id": "UMLS:C0237820", + "subject_id": "UBERON:0000044", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", - "object_category": "biolink:Activity", + "subject_category": "biolink:Cell", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0079925", - "object_id": "UMLS:C0237820", + "subject_id": "UMLS:C0009013", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:GeneFamily", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200395", - "object_id": "CHEMBL.TARGET:CHEMBL2331043", + "subject_id": "UMLS:C0205082", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20271,158 +19490,158 @@ ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:MolecularMixture", + "subject_category": "biolink:Disease", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.TARGET:CHEMBL2179", - "object_id": "PUBCHEM.COMPOUND:70697642", + "subject_id": "MONDO:0001576", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Protein", + "subject_category": "biolink:GenomicEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1481", - "object_id": "PR:000006120", + "subject_id": "UMLS:C0002085", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D000438", - "object_id": "PR:000006122", + "subject_id": "UBERON:0000947", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1083993", - "object_id": "PR:000006130", + "subject_id": "UMLS:C0012929", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Drug", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "PR:000006102", - "object_id": "UMLS:C2684108", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:PhysicalEntity", "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MONDO:0002406", - "object_id": "UMLS:C0221928", + "subject_id": "UMLS:C0015919", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:CellularComponent", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:DiseaseOrPhenotypicFeature", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1515464", - "object_id": "UMLS:C1520749", + "subject_id": "UMLS:C0205160", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:DiseaseOrPhenotypicFeature", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:NucleicAcidEntity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0033213", - "object_id": "UMLS:C4723885", + "subject_id": "NCBIGene:140821", + "object_id": "UMLS:C0449238", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Disease", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:BiologicalEntity", + "object_category": "biolink:DiseaseOrPhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "MONDO:0005044", - "object_id": "UMLS:C4552608", + "subject_id": "MESH:D016753", + "object_id": "UMLS:C0205161", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Protein", + "subject_category": "biolink:CellularComponent", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201513", - "object_id": "PR:000003252", + "subject_id": "UMLS:C1515464", + "object_id": "UMLS:C1520749", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Drug", - "object_category": "biolink:Protein", + "subject_category": "biolink:Disease", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "NCIT:C116928", - "object_id": "PR:000006130", + "subject_id": "MONDO:0005044", + "object_id": "UMLS:C4552608", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "localization" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Event", + "subject_category": "biolink:Cell", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:24857", - "object_id": "UMLS:C0681792", + "subject_id": "UMLS:C0005773", + "object_id": "UMLS:C1520768", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20461,20 +19680,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:SmallMolecule", + "object_category": "biolink:Event", "predicate": "biolink:causes", - "subject_id": "UMLS:C0005773", - "object_id": "UMLS:C1520768", + "subject_id": "PUBCHEM.COMPOUND:24857", + "object_id": "UMLS:C0681792", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20482,8 +19701,8 @@ "subject_category": "biolink:SmallMolecule", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11001318", - "object_id": "PR:000016801", + "subject_id": "CHEMBL.COMPOUND:CHEMBL4650301", + "object_id": "CHEMBL.TARGET:CHEMBL2487", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -20518,15 +19737,15 @@ ] }, { - "subject_category": "biolink:BiologicalProcess", - "object_category": "biolink:GenomicEntity", + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "GO:0018101", - "object_id": "UMLS:C4321262", + "subject_id": "UMLS:C0020964", + "object_id": "UMLS:C0879438", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20534,64 +19753,64 @@ "subject_category": "biolink:Disease", "object_category": "biolink:Cell", "predicate": "biolink:causes", - "subject_id": "MONDO:0005070", - "object_id": "UMLS:C0879438", + "subject_id": "MONDO:0004992", + "object_id": "UMLS:C0879593", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:CellularComponent", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:10836", - "object_id": "UMLS:C0238711", + "subject_id": "UMLS:C1519692", + "object_id": "UMLS:C1520625", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:16131300", - "object_id": "UMLS:C0240321", + "subject_id": "PUBCHEM.COMPOUND:123925", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:PopulationOfIndividualOrganisms", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D008076", - "object_id": "UMLS:C0240321", + "subject_id": "PUBCHEM.COMPOUND:133128", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ComplexMolecularMixture", - "object_category": "biolink:DiseaseOrPhenotypicFeature", + "subject_category": "biolink:Protein", + "object_category": "biolink:Polypeptide", "predicate": "biolink:causes", - "subject_id": "MESH:D014612", - "object_id": "UMLS:C1519885", + "subject_id": "UMLS:C0003601", + "object_id": "UMLS:C1511997", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20609,75 +19828,114 @@ ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:CellularComponent", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Procedure", "predicate": "biolink:causes", - "subject_id": "UMLS:C1519692", - "object_id": "UMLS:C1520625", + "subject_id": "UMLS:C0441650", + "object_id": "UMLS:C0556030", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Protein", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:GeneticInheritance", + "object_category": "biolink:Procedure", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0040649", + "object_id": "UMLS:C1515979", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:MolecularActivity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0318759", + "object_id": "UMLS:C1518440", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:ComplexMolecularMixture", + "object_category": "biolink:DiseaseOrPhenotypicFeature", + "predicate": "biolink:causes", + "subject_id": "MESH:D014612", + "object_id": "UMLS:C0033213", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "UMLS:C0003601", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C0011313", + "object_id": "UMLS:C0318761", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Drug", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:123925", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C0003280", + "object_id": "UMLS:C0318759", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Polypeptide", + "subject_category": "biolink:Activity", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:133128", - "object_id": "UMLS:C1511997", + "subject_id": "UMLS:C0599946", + "object_id": "UMLS:C0011313", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GeneticInheritance", - "object_category": "biolink:Procedure", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:GenomicEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0040649", - "object_id": "UMLS:C1515979", + "subject_id": "UBERON:0014374", + "object_id": "UMLS:C1705280", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhysiologicalProcess", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0000934", + "subject_id": "UMLS:C1510470", "object_id": "UMLS:C0279023", "qualifiers": [ { @@ -20687,10 +19945,10 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1510470", + "subject_id": "UMLS:C0000934", "object_id": "UMLS:C0279023", "qualifiers": [ { @@ -20707,8 +19965,8 @@ "object_id": "UniProtKB:Q9BXT5", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, @@ -20716,12 +19974,12 @@ "subject_category": "biolink:NamedThing", "object_category": "biolink:Food", "predicate": "biolink:causes", - "subject_id": "MESH:D055432", + "subject_id": "NCIT:C49019", "object_id": "UMLS:C1572543", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20738,6 +19996,45 @@ } ] }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Activity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0013081", + "object_id": "UMLS:C0599946", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:PhysiologicalProcess", + "object_category": "biolink:Activity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0001272", + "object_id": "UMLS:C0599946", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, + { + "subject_category": "biolink:OrganismTaxon", + "object_category": "biolink:Activity", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0011313", + "object_id": "UMLS:C0599946", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, { "subject_category": "biolink:PhysiologicalProcess", "object_category": "biolink:PopulationOfIndividualOrganisms", @@ -20747,46 +20044,46 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Disease", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "MONDO:0004992", + "subject_id": "MESH:C110027", "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:PhenotypicFeature", + "subject_category": "biolink:Disease", "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UMLS:C0442751", + "subject_id": "MONDO:0004992", "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:AnatomicalEntity", "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "MESH:C110027", + "subject_id": "UBERON:0010163", "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20804,15 +20101,15 @@ ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:PhenotypicFeature", "object_category": "biolink:PopulationOfIndividualOrganisms", "predicate": "biolink:causes", - "subject_id": "UBERON:0010163", + "subject_id": "UMLS:C1290928", "object_id": "UMLS:C0696628", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20830,62 +20127,62 @@ ] }, { - "subject_category": "biolink:Procedure", - "object_category": "biolink:Behavior", + "subject_category": "biolink:MolecularMixture", + "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0054889", - "object_id": "UMLS:C1331418", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1200395", + "object_id": "CHEMBL.TARGET:CHEMBL2094124", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:IndividualOrganism", + "subject_category": "biolink:Procedure", + "object_category": "biolink:Behavior", "predicate": "biolink:causes", - "subject_id": "MESH:C084795", - "object_id": "UMLS:C0677040", + "subject_id": "UMLS:C0054889", + "object_id": "UMLS:C1331418", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Protein", + "subject_category": "biolink:Gene", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0019046", + "subject_id": "NCBIGene:1806", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "MESH:D000447", + "subject_id": "PUBCHEM.COMPOUND:1014", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GenomicEntity", + "subject_category": "biolink:Protein", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0002085", + "subject_id": "UMLS:C0019046", "object_id": "UMLS:C0677040", "qualifiers": [ { @@ -20895,15 +20192,15 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:1014", + "subject_id": "MESH:D000447", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20921,15 +20218,15 @@ ] }, { - "subject_category": "biolink:Gene", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "NCBIGene:1806", + "subject_id": "MESH:C084795", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -20942,7 +20239,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -20955,28 +20252,28 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Polypeptide", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "UMLS:C0006556", + "subject_id": "PUBCHEM.COMPOUND:166717", "object_id": "UMLS:C0677040", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:GenomicEntity", "object_category": "biolink:IndividualOrganism", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:166717", + "subject_id": "UMLS:C0002085", "object_id": "UMLS:C0677040", "qualifiers": [ { @@ -20985,6 +20282,19 @@ } ] }, + { + "subject_category": "biolink:Polypeptide", + "object_category": "biolink:IndividualOrganism", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0006556", + "object_id": "UMLS:C0677040", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" + } + ] + }, { "subject_category": "biolink:Polypeptide", "object_category": "biolink:NamedThing", @@ -20994,7 +20304,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -21006,8 +20316,8 @@ "object_id": "CHEMBL.COMPOUND:CHEMBL2103797", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "abundance" } ] }, @@ -21046,20 +20356,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" - } - ] - }, - { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularEntity", - "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1200395", - "object_id": "CHEMBL.TARGET:CHEMBL2094124", - "qualifiers": [ - { - "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, @@ -21085,7 +20382,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, @@ -21098,7 +20395,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -21111,7 +20408,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -21124,146 +20421,211 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "GO:0005219", + "object_id": "UniProtKB:P0DP23", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:Protein", + "predicate": "biolink:causes", + "subject_id": "GO:0004383", + "object_id": "UniProtKB:P43080", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:NamedThing", + "object_category": "biolink:NamedThing", + "predicate": "biolink:causes", + "subject_id": "OBO:INO_0000072", + "object_id": "OBO:INO_0000173", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" + } + ] + }, + { + "subject_category": "biolink:NamedThing", + "object_category": "biolink:NamedThing", + "predicate": "biolink:causes", + "subject_id": "OBO:INO_0000074", + "object_id": "OBO:INO_0000173", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:Disease", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0034917", + "object_id": "UMLS:C0238876", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Activity", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "GO:0005219", - "object_id": "UniProtKB:P0DP23", + "subject_id": "UMLS:C0150141", + "object_id": "UMLS:C0302295", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularActivity", - "object_category": "biolink:Protein", + "subject_category": "biolink:Phenomenon", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "GO:0004383", - "object_id": "UniProtKB:P43080", + "subject_id": "UMLS:C0013203", + "object_id": "UMLS:C1373120", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", - "object_category": "biolink:Gene", + "subject_category": "biolink:AnatomicalEntity", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C1831828", - "object_id": "NCBIGene:2703462", + "subject_id": "UBERON:0000178", + "object_id": "UMLS:C1373124", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Activity", - "object_category": "biolink:Disease", + "subject_category": "biolink:GrossAnatomicalStructure", + "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0150141", - "object_id": "UMLS:C0302295", + "subject_id": "UBERON:0000948", + "object_id": "UMLS:C1373051", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:PhenotypicFeature", + "object_category": "biolink:OrganismTaxon", "predicate": "biolink:causes", - "subject_id": "OBO:INO_0000074", - "object_id": "OBO:INO_0000173", + "subject_id": "HP:0032326", + "object_id": "UMLS:C1295823", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "downregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:NamedThing", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:Device", "predicate": "biolink:causes", - "subject_id": "OBO:INO_0000072", - "object_id": "OBO:INO_0000173", + "subject_id": "MESH:D016207", + "object_id": "UMLS:C0450138", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "upregulated" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:Phenomenon", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:ClinicalAttribute", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "UMLS:C0013203", - "object_id": "UMLS:C1373120", + "subject_id": "UMLS:C0007165", + "object_id": "UMLS:C0543421", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:AnatomicalEntity", + "subject_category": "biolink:Cell", "object_category": "biolink:MolecularActivity", "predicate": "biolink:causes", - "subject_id": "UBERON:0000178", - "object_id": "UMLS:C1373124", + "subject_id": "UMLS:C0225828", + "object_id": "UMLS:C0675244", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Publication", + "object_category": "biolink:Disease", "predicate": "biolink:causes", - "subject_id": "UMLS:C0004561", - "object_id": "UMLS:C1515672", + "subject_id": "UMLS:C0599740", + "object_id": "UMLS:C1140999", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:GrossAnatomicalStructure", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:Cell", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UBERON:0000948", - "object_id": "UMLS:C1373051", + "subject_id": "UMLS:C0027950", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:PhenotypicFeature", - "object_category": "biolink:Disease", + "subject_category": "biolink:Gene", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0034917", - "object_id": "UMLS:C0238876", + "subject_id": "NCBIGene:2357", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21272,11 +20634,11 @@ ] }, { - "subject_category": "biolink:Cell", - "object_category": "biolink:MolecularActivity", + "subject_category": "biolink:NamedThing", + "object_category": "biolink:ClinicalAttribute", "predicate": "biolink:causes", - "subject_id": "UMLS:C0225828", - "object_id": "UMLS:C0675244", + "subject_id": "UMLS:C0699251", + "object_id": "UMLS:C1115729", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21285,15 +20647,15 @@ ] }, { - "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:Device", + "subject_category": "biolink:MolecularActivity", + "object_category": "biolink:InformationContentEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D016207", - "object_id": "UMLS:C0450138", + "subject_id": "UMLS:C0279023", + "object_id": "UMLS:C1510470", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, @@ -21306,7 +20668,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity_or_abundance" } ] }, @@ -21337,10 +20699,10 @@ ] }, { - "subject_category": "biolink:InformationContentEntity", + "subject_category": "biolink:Activity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0849355", + "subject_id": "UMLS:C0035028", "object_id": "UMLS:C0233929", "qualifiers": [ { @@ -21350,10 +20712,10 @@ ] }, { - "subject_category": "biolink:Activity", + "subject_category": "biolink:InformationContentEntity", "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "UMLS:C0035028", + "subject_id": "UMLS:C0849355", "object_id": "UMLS:C0233929", "qualifiers": [ { @@ -21376,41 +20738,41 @@ ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:NamedThing", + "subject_category": "biolink:Cell", + "object_category": "biolink:AnatomicalEntity", "predicate": "biolink:causes", - "subject_id": "MESH:D014357", - "object_id": "UMLS:C1149593", + "subject_id": "UMLS:C0024432", + "object_id": "UMLS:C0369078", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "activity or abundance" + "qualifier_value": "activity" } ] }, { - "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:Protein", + "subject_category": "biolink:PopulationOfIndividualOrganisms", + "object_category": "biolink:PhenotypicFeature", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:71587550", - "object_id": "UniProtKB:P06434", + "subject_id": "UMLS:C0696628", + "object_id": "UMLS:C1290928", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "expression" + "qualifier_value": "activity_or_abundance" } ] }, { - "subject_category": "biolink:OrganismTaxon", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:Protein", "predicate": "biolink:causes", - "subject_id": "UMLS:C1831828", - "object_id": "UniProtKB:P09252", + "subject_id": "PUBCHEM.COMPOUND:71587550", + "object_id": "UniProtKB:P06434", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "expression" } ] }, @@ -21428,50 +20790,50 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:ChemicalEntity", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11284169", - "object_id": "CHEMBL.TARGET:CHEMBL2095182", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201465", + "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL2108628", - "object_id": "CHEMBL.TARGET:CHEMBL2095182", + "subject_id": "PUBCHEM.COMPOUND:9002", + "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "stability" + "qualifier_value": "degradation" } ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:MolecularMixture", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL4650322", - "object_id": "CHEMBL.TARGET:CHEMBL2111348", + "subject_id": "PUBCHEM.COMPOUND:8519", + "object_id": "CHEMBL.TARGET:CHEMBL2364181", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" } ] }, { "subject_category": "biolink:ChemicalEntity", - "object_category": "biolink:MolecularEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL1201465", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "CHEMBL.COMPOUND:CHEMBL1201512", + "object_id": "CHEMBL.TARGET:CHEMBL2364186", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21481,10 +20843,10 @@ }, { "subject_category": "biolink:MolecularMixture", - "object_category": "biolink:MolecularEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:8519", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "PUBCHEM.COMPOUND:71587550", + "object_id": "CHEMBL.TARGET:CHEMBL2364186", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21493,28 +20855,28 @@ ] }, { - "subject_category": "biolink:SmallMolecule", - "object_category": "biolink:MolecularEntity", + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:9002", - "object_id": "CHEMBL.TARGET:CHEMBL2364181", + "subject_id": "CHEMBL.COMPOUND:CHEMBL3137338", + "object_id": "CHEMBL.TARGET:CHEMBL4635143", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", - "qualifier_value": "degradation" + "qualifier_value": "abundance" } ] }, { - "subject_category": "biolink:ChemicalEntity", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:NucleicAcidEntity", "predicate": "biolink:causes", - "subject_id": "CHEMBL.COMPOUND:CHEMBL3137338", - "object_id": "CHEMBL.TARGET:CHEMBL4635143", + "subject_id": "PUBCHEM.COMPOUND:121492004", + "object_id": "CHEMBL.TARGET:CHEMBL4296221", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "degradation" } ] }, @@ -21526,8 +20888,8 @@ "object_id": "CHEMBL.TARGET:CHEMBL4630576", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "abundance" } ] }, @@ -21539,21 +20901,34 @@ "object_id": "CHEMBL.TARGET:CHEMBL4630576", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "abundance" } ] }, { - "subject_category": "biolink:MolecularMixture", + "subject_category": "biolink:SmallMolecule", "object_category": "biolink:MolecularEntity", "predicate": "biolink:causes", - "subject_id": "PUBCHEM.COMPOUND:11953895", - "object_id": "CHEMBL.TARGET:CHEMBL2111348", + "subject_id": "PUBCHEM.COMPOUND:11284169", + "object_id": "CHEMBL.TARGET:CHEMBL2095182", "qualifiers": [ { - "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "stability" + } + ] + }, + { + "subject_category": "biolink:ChemicalEntity", + "object_category": "biolink:MolecularEntity", + "predicate": "biolink:causes", + "subject_id": "CHEMBL.COMPOUND:CHEMBL2108628", + "object_id": "CHEMBL.TARGET:CHEMBL2095182", + "qualifiers": [ + { + "qualifier_type_id": "biolink:aspect_qualifier", + "qualifier_value": "stability" } ] }, @@ -21584,11 +20959,11 @@ ] }, { - "subject_category": "biolink:SmallMolecule", + "subject_category": "biolink:Publication", "object_category": "biolink:NucleicAcidEntity", - "predicate": "biolink:affects", - "subject_id": "PUBCHEM.COMPOUND:92337", - "object_id": "NCBIGene:8081", + "predicate": "biolink:causes", + "subject_id": "UMLS:C0599740", + "object_id": "NCBIGene:57762", "qualifiers": [ { "qualifier_type_id": "biolink:aspect_qualifier", @@ -21605,7 +20980,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "increased" + "qualifier_value": "upregulated" } ] }, @@ -21618,7 +20993,7 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" } ] }, @@ -21631,7 +21006,20 @@ "qualifiers": [ { "qualifier_type_id": "biolink:direction_qualifier", - "qualifier_value": "decreased" + "qualifier_value": "downregulated" + } + ] + }, + { + "subject_category": "biolink:Gene", + "object_category": "biolink:BiologicalProcess", + "predicate": "biolink:causes", + "subject_id": "NCBIGene:3170", + "object_id": "REACT:R-HSA-9796300", + "qualifiers": [ + { + "qualifier_type_id": "biolink:direction_qualifier", + "qualifier_value": "upregulated" } ] } diff --git a/code/ARAX/test/test_ARAX_expand.py b/code/ARAX/test/test_ARAX_expand.py index a3cbc835c..884eaf163 100644 --- a/code/ARAX/test/test_ARAX_expand.py +++ b/code/ARAX/test/test_ARAX_expand.py @@ -360,7 +360,7 @@ def test_cohd_expand(): ] nodes_by_qg_id, edges_by_qg_id = _run_query_and_do_standard_testing(actions_list) - +@pytest.mark.skip(reason="retire DTD") def test_dtd_expand_1(): actions_list = [ "add_qnode(name=acetaminophen, key=n0)", @@ -376,7 +376,8 @@ def test_dtd_expand_1(): assert all([edges_by_qg_id[qedge_key][edge_key].attributes[0].value_url == "https://doi.org/10.1101/765305" for qedge_key in edges_by_qg_id for edge_key in edges_by_qg_id[qedge_key]]) -@pytest.mark.slow +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_dtd_expand_2(): actions_list = [ "add_qnode(name=acetaminophen, key=n0)", @@ -711,9 +712,19 @@ def test_kg2_predicate_hierarchy_reasoning(): ] nodes_by_qg_id, edges_by_qg_id = _run_query_and_do_standard_testing(actions_list) assert any(edge for edge in edges_by_qg_id["e00"].values() if edge.predicate == "biolink:affects") - assert any(edge for edge in edges_by_qg_id["e00"].values() if edge.predicate == "biolink:regulates") assert not any(edge for edge in edges_by_qg_id["e00"].values() if edge.predicate == "biolink:related_to") +@pytest.mark.skip(reason="Dev testing for domain range exclusion") +def test_domain_range_exclusion(): + actions_list = [ + "add_qnode(ids=UMLS:C1510438, key=n00)", + "add_qnode(categories=biolink:Disease, key=n01)", + "add_qedge(subject=n00, object=n01, key=e00, predicates=biolink:diagnoses)", + "expand(kp=infores:rtx-kg2)", + "return(message=true, store=false)" + ] + nodes_by_qg_id, edges_by_qg_id = _run_query_and_do_standard_testing(actions_list) + assert False @pytest.mark.slow def test_issue_1373_pinned_curies(): @@ -1096,7 +1107,7 @@ def test_xdtd_expand(): query = { "nodes": { "disease": { - "ids": ["MONDO:0017979"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:ChemicalEntity"] @@ -1133,7 +1144,7 @@ def test_xdtd_different_categories(): query = { "nodes": { "disease": { - "ids": ["MONDO:0005615"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:Drug"] @@ -1152,7 +1163,7 @@ def test_xdtd_different_categories(): query = { "nodes": { "disease": { - "ids": ["MONDO:0005615"], + "ids": ["MONDO:0015564"], "categories": ["biolink:Disease"] }, "chemical": { @@ -1172,7 +1183,7 @@ def test_xdtd_different_categories(): query = { "nodes": { "disease": { - "ids": ["MONDO:0005615"], + "ids": ["MONDO:0015564"], "categories": ["biolink:DiseaseOrPhenotypicFeature"] }, "chemical": { @@ -1195,7 +1206,7 @@ def test_xdtd_multiple_categories(): query = { "nodes": { "disease": { - "ids": ["UMLS:C5419466"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:Drug", "biolink:ChemicalMixture"] @@ -1217,7 +1228,7 @@ def test_xdtd_different_predicates(): query = { "nodes": { "disease": { - "ids": ["UMLS:C5419466"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:Drug", "biolink:ChemicalMixture"] diff --git a/code/ARAX/test/test_ARAX_infer.py b/code/ARAX/test/test_ARAX_infer.py index 9a51f2738..989055a81 100644 --- a/code/ARAX/test/test_ARAX_infer.py +++ b/code/ARAX/test/test_ARAX_infer.py @@ -79,10 +79,10 @@ def _virtual_tester(message: Message, edge_predicate: str, relation: str, attrib assert len(values) >= num_different_values -def test_xdtd_infer_diabetes_1(): +def test_xdtd_infer_castleman_disease_1(): query = {"operations": {"actions": [ "create_message", - "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0005148)", + "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0015564)", "return(message=true, store=true)" ]}} [response, message] = _do_arax_query(query) @@ -91,10 +91,10 @@ def test_xdtd_infer_diabetes_1(): assert len(message.query_graph.edges) == 1 assert len(message.results) > 0 -def test_xdtd_infer_diabetes_2(): +def test_xdtd_infer_castleman_disease_2(): query = {"operations": {"actions": [ "create_message", - "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0005148,n_drugs=2,n_paths=15)", + "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0015564,n_drugs=2,n_paths=15)", "return(message=true, store=true)" ]}} [response, message] = _do_arax_query(query) @@ -141,7 +141,7 @@ def test_xdtd_with_qg2(): "message": {"query_graph": { "nodes": { "disease": { - "ids": ["MONDO:0003912"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:ChemicalEntity"] @@ -158,7 +158,7 @@ def test_xdtd_with_qg2(): } }, "operations": {"actions": [ - "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0003912,qedge_id=t_edge)", + "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0015564,qedge_id=t_edge)", "return(message=true, store=true)" ]} } @@ -174,7 +174,7 @@ def test_xdtd_with_qg3(): "message": {"query_graph": { "nodes": { "disease": { - "ids": ["MONDO:0017979"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:ChemicalEntity"] @@ -191,7 +191,7 @@ def test_xdtd_with_qg3(): } }, "operations": {"actions": [ - "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0017979,qedge_id=t_edge,n_drugs=10,n_paths=10)", + "infer(action=drug_treatment_graph_expansion,node_curie=MONDO:0015564,qedge_id=t_edge,n_drugs=10,n_paths=10)", "return(message=true, store=true)" ]} } @@ -206,7 +206,7 @@ def test_xdtd_with_only_qg(): "message": {"query_graph": { "nodes": { "disease": { - "ids": ["MONDO:0003912"] + "ids": ["MONDO:0015564"] }, "chemical": { "categories": ["biolink:ChemicalEntity"] diff --git a/code/ARAX/test/test_ARAX_overlay.py b/code/ARAX/test/test_ARAX_overlay.py index 9e6769bfa..86bbe164f 100644 --- a/code/ARAX/test/test_ARAX_overlay.py +++ b/code/ARAX/test/test_ARAX_overlay.py @@ -458,7 +458,8 @@ def test_chi_square_attribute(): # CM: I changed 'MONDO:0004992' to 'DOID:0080909' for a more specific disease -@pytest.mark.slow +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_predict_drug_treats_disease_virtual(): query = {"operations": {"actions": [ "create_message", @@ -477,7 +478,8 @@ def test_predict_drug_treats_disease_virtual(): # CM: I changed 'MONDO:0004992' to 'DOID:0080909' for a more specific disease -@pytest.mark.slow +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_predict_drug_treats_disease_attribute(): query = {"operations": {"actions": [ "create_message", @@ -496,7 +498,8 @@ def test_predict_drug_treats_disease_attribute(): # CM: I changed 'MONDO:0004992' to 'DOID:0080909' for a more specific disease -@pytest.mark.slow +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_issue_832(): query = {"operations": {"actions": [ "create_message", @@ -514,7 +517,8 @@ def test_issue_832(): _virtual_tester(message, 'biolink:probably_treats', 'P1', 'probability_treats', 'EDAM-DATA:0951', 2) -@pytest.mark.slow +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_issue_832_non_drug(): query = {"operations": {"actions": [ "create_message", @@ -607,8 +611,9 @@ def test_issue_840_non_drug(): assert attribute.original_attribute_name != 'paired_concept_frequency' -@pytest.mark.external -@pytest.mark.slow +# @pytest.mark.external +# @pytest.mark.slow +@pytest.mark.skip(reason="retire DTD") def test_issue_892(): query = {"operations": {"actions": [ "add_qnode(ids=DOID:11830, categories=biolink:Disease, key=n00)", diff --git a/code/ARAX/test/test_ARAX_workflows.py b/code/ARAX/test/test_ARAX_workflows.py index eb24a81e2..a6c4a4dfd 100644 --- a/code/ARAX/test/test_ARAX_workflows.py +++ b/code/ARAX/test/test_ARAX_workflows.py @@ -125,7 +125,7 @@ def test_example_2(): "overlay(action=compute_jaccard, start_node_key=n00, intermediate_node_key=n01, end_node_key=n02, virtual_relation_label=J1)", "filter_kg(action=remove_edges_by_continuous_attribute, edge_attribute=jaccard_index, direction=below, threshold=.2, remove_connected_nodes=t, qnode_keys=[n02])", "filter_kg(action=remove_edges_by_discrete_attribute,edge_attribute=provided_by, value=Pharos)", - "overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1, threshold=0)", + # "overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1, threshold=0)", "resultify(ignore_edge_direction=true)", "filter_results(action=sort_by_edge_attribute, edge_attribute=jaccard_index, direction=descending, max_results=15)", "return(message=true, store=false)", @@ -134,7 +134,7 @@ def test_example_2(): assert response.status == 'OK' assert len(message.results) > 0 # :BUG: sometimes the workflow returns 47 results, sometimes 48 (!?) assert message.results[0].essence is not None - _virtual_tester(message, 'biolink:probably_treats', 'P1', 'probability_treats', 'EDAM-DATA:0951', 2) + # _virtual_tester(message, 'biolink:probably_treats', 'P1', 'probability_treats', 'EDAM-DATA:0951', 2) _virtual_tester(message, 'biolink:has_jaccard_index_with', 'J1', 'jaccard_index', 'EDAM-DATA:1772', 2) @@ -514,7 +514,7 @@ def test_two_hop_based_on_types_1(): "overlay(action=overlay_clinical_info, paired_concept_frequency=true, subject_qnode_key=n00, object_qnode_key=n02, virtual_relation_label=C1)", "overlay(action=overlay_clinical_info, observed_expected_ratio=true, subject_qnode_key=n00, object_qnode_key=n02, virtual_relation_label=C2)", "overlay(action=overlay_clinical_info, chi_square=true, subject_qnode_key=n00, object_qnode_key=n02, virtual_relation_label=C3)", - "overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1)", + # "overlay(action=predict_drug_treats_disease, subject_qnode_key=n02, object_qnode_key=n00, virtual_relation_label=P1)", "overlay(action=compute_ngd)", "resultify(ignore_edge_direction=true)", "filter_results(action=limit_number_of_results, max_results=50)", @@ -546,7 +546,7 @@ def test_one_hop_based_on_types_1(): "expand(edge_key=e00, infores:rtx-kg2)", "expand(edge_key=e00, kp=infores:biothings-explorer)", "overlay(action=overlay_clinical_info, observed_expected_ratio=true)", - "overlay(action=predict_drug_treats_disease)", + # "overlay(action=predict_drug_treats_disease)", "filter_kg(action=remove_edges_by_continuous_attribute, edge_attribute=probability_treats, direction=below, threshold=0.75, remove_connected_nodes=true, qnode_keys=[n01])", "overlay(action=compute_ngd)", "resultify(ignore_edge_direction=true)", @@ -573,7 +573,7 @@ def test_one_hop_kitchen_sink_BTE_1(): "overlay(action=overlay_clinical_info, paired_concept_frequency=true)", "overlay(action=overlay_clinical_info, observed_expected_ratio=true)", "overlay(action=overlay_clinical_info, chi_square=true)", - "overlay(action=predict_drug_treats_disease)", + # "overlay(action=predict_drug_treats_disease)", "overlay(action=compute_ngd)", "resultify(ignore_edge_direction=true)", "filter_results(action=limit_number_of_results, max_results=50)", @@ -602,7 +602,7 @@ def test_one_hop_kitchen_sink_BTE_2(): "overlay(action=overlay_clinical_info, paired_concept_frequency=true)", "overlay(action=overlay_clinical_info, observed_expected_ratio=true)", "overlay(action=overlay_clinical_info, chi_square=true)", - "overlay(action=predict_drug_treats_disease)", + # "overlay(action=predict_drug_treats_disease)", "overlay(action=compute_ngd)", "resultify(ignore_edge_direction=true)", "filter_results(action=limit_number_of_results, max_results=50)", @@ -685,7 +685,7 @@ def test_ranker_float_error_ex1(): "overlay(action=compute_ngd, virtual_relation_label=N1, subject_qnode_key=n0, object_qnode_key=n1)", "overlay(action=fisher_exact_test,subject_qnode_key=n0,virtual_relation_label=F1,object_qnode_key=n1)", "overlay(action=overlay_clinical_info,COHD_method=paired_concept_frequency,virtual_relation_label=C1,subject_qnode_key=n0,object_qnode_key=n1)", - "overlay(action=predict_drug_treats_disease,virtual_relation_label=P1,subject_qnode_key=n0,object_qnode_key=n1,threshold=0.8,slow_mode=false)", + # "overlay(action=predict_drug_treats_disease,virtual_relation_label=P1,subject_qnode_key=n0,object_qnode_key=n1,threshold=0.8,slow_mode=false)", "resultify()", "filter_results(action=limit_number_of_results, max_results=30)", "return(message=true, store=false)" diff --git a/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml b/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml index 4131c48bd..1cb0f8472 100644 --- a/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml +++ b/code/UI/OpenAPI/python-flask-server/KG2/openapi_server/openapi/openapi.yaml @@ -9,7 +9,7 @@ info: url: http://www.apache.org/licenses/LICENSE-2.0.html termsOfService: https://github.com/RTXteam/RTX/blob/master/LICENSE title: RTX KG2 - TRAPI 1.4.0 - version: 2.8.3 + version: 2.8.4 x-translator: component: KP team: diff --git a/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml b/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml index 9e90b1d54..418f263a6 100644 --- a/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml +++ b/code/UI/OpenAPI/python-flask-server/openapi_server/openapi/openapi.yaml @@ -9,7 +9,7 @@ info: url: http://www.apache.org/licenses/LICENSE-2.0.html termsOfService: https://github.com/RTXteam/RTX/blob/master/LICENSE title: ARAX Translator Reasoner - TRAPI 1.4.0 - version: 1.4.2 + version: 1.4.3 x-translator: component: ARA team: diff --git a/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_ARAX.yaml b/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_ARAX.yaml index 3747b5d26..69f269866 100644 --- a/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_ARAX.yaml +++ b/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_ARAX.yaml @@ -1,7 +1,7 @@ openapi: 3.0.1 info: description: TRAPI 1.4 endpoint for the NCATS Biomedical Translator Reasoner called ARAX - version: 1.4.2 + version: 1.4.3 title: ARAX Translator Reasoner contact: email: edeutsch@systemsbiology.org diff --git a/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_KG2.yaml b/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_KG2.yaml index 7682c8d0f..b4a9edee9 100644 --- a/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_KG2.yaml +++ b/code/UI/OpenAPI/specifications/working/RTX_OA3_TRAPI1.4_KG2.yaml @@ -1,7 +1,7 @@ openapi: 3.0.1 info: description: TRAPI 1.4 endpoint for the NCATS Biomedical Translator KP called RTX KG2 - version: 2.8.3 + version: 2.8.4 title: RTX KG2 contact: email: edeutsch@systemsbiology.org diff --git a/code/config_dbs.json b/code/config_dbs.json index 3bb2fb3d8..bc49f3ecc 100644 --- a/code/config_dbs.json +++ b/code/config_dbs.json @@ -1,12 +1,12 @@ { "database_downloads": { - "node_synonymizer": "/translator/data/orangeboard/databases/KG2.8.3/node_synonymizer_v1.0_KG2.8.3.sqlite", - "kg2c_sqlite": "/translator/data/orangeboard/databases/KG2.8.3/kg2c_v1.0_KG2.8.3.sqlite", - "kg2c_meta_kg": "/translator/data/orangeboard/databases/KG2.8.3/meta_kg_v1.0_KG2.8.3c.json", - "fda_approved_drugs": "/translator/data/orangeboard/databases/KG2.8.3/fda_approved_drugs_v1.0_KG2.8.3c.pickle", - "autocomplete": "/translator/data/orangeboard/databases/KG2.8.3/autocomplete_v1.0_KG2.8.3.sqlite", - "curie_to_pmids": "/translator/data/orangeboard/databases/KG2.8.3/curie_to_pmids_v1.0_KG2.8.3.sqlite", - "explainable_dtd_db": "/translator/data/orangeboard/databases/KG2.8.3/ExplainableDTD_v1.0_KG2.8.3_refresh.db", + "node_synonymizer": "/translator/data/orangeboard/databases/KG2.8.4/node_synonymizer_v1.0_KG2.8.4.sqlite", + "kg2c_sqlite": "/translator/data/orangeboard/databases/KG2.8.4/kg2c_v1.0_KG2.8.4.sqlite", + "kg2c_meta_kg": "/translator/data/orangeboard/databases/KG2.8.4/meta_kg_v1.0_KG2.8.4c.json", + "fda_approved_drugs": "/translator/data/orangeboard/databases/KG2.8.4/fda_approved_drugs_v1.0_KG2.8.4c.pickle", + "autocomplete": "/translator/data/orangeboard/databases/KG2.8.4/autocomplete_v1.0_KG2.8.4.sqlite", + "curie_to_pmids": "/translator/data/orangeboard/databases/KG2.8.4/curie_to_pmids_v1.0_KG2.8.4.sqlite", + "explainable_dtd_db": "/translator/data/orangeboard/databases/KG2.8.4/ExplainableDTD_v1.0_KG2.8.3_refreshedTo_KG2.8.4.db", "cohd_database": "/translator/data/orangeboard/databases/KG2.8.0/COHDdatabase_v1.0_KG2.8.0.db", "graph_database": "/translator/data/orangeboard/databases/KG2.8.0.1/GRAPH_v1.0_KG2.8.0.1_refreshed.sqlite", "dtd_prob": "/translator/data/orangeboard/databases/KG2.8.0.1/DTD_probability_database_v1.0_KG2.8.0.1_refreshed.db", @@ -23,7 +23,7 @@ "prod": "https://kg2cploverdb.transltr.io" }, "neo4j": { - "KG2pre": "kg2endpoint-kg2-8-3.rtx.ai", - "KG2c": "kg2-8-3c.rtx.ai" + "KG2pre": "kg2endpoint-kg2-8-4.rtx.ai", + "KG2c": "kg2-8-4c.rtx.ai" } } diff --git a/code/kg2c/create_kg2c_files.py b/code/kg2c/create_kg2c_files.py index 58f1e6d4d..767b7ae65 100644 --- a/code/kg2c/create_kg2c_files.py +++ b/code/kg2c/create_kg2c_files.py @@ -58,7 +58,8 @@ "publications_info": {"type": dict, "in_kg2pre": True, "in_kg2c_lite": False}, "qualified_predicate": {"type": str, "in_kg2pre": True, "in_kg2c_lite": True}, "qualified_object_aspect": {"type": str, "in_kg2pre": True, "in_kg2c_lite": True}, - "qualified_object_direction": {"type": str, "in_kg2pre": True, "in_kg2c_lite": True} + "qualified_object_direction": {"type": str, "in_kg2pre": True, "in_kg2c_lite": True}, + "domain_range_exclusion" : {"type": str, "in_kg2pre": True, "in_kg2c_lite": True} } } @@ -280,7 +281,7 @@ def _create_node(preferred_curie: str, name: Optional[str], category: str, all_c def _create_edge(subject: str, object: str, predicate: str, primary_knowledge_source: str, publications: List[str], publications_info: Dict[str, any], kg2_ids: List[str], - qualified_predicate, qualified_object_aspect, qualified_object_direction) -> Dict[str, any]: + qualified_predicate, qualified_object_aspect, qualified_object_direction, domain_range_exclusion) -> Dict[str, any]: edge_properties_lookup = PROPERTIES_LOOKUP["edges"] assert isinstance(subject, edge_properties_lookup["subject"]["type"]) assert isinstance(object, edge_properties_lookup["object"]["type"]) @@ -292,6 +293,7 @@ def _create_edge(subject: str, object: str, predicate: str, primary_knowledge_so assert isinstance(qualified_predicate, edge_properties_lookup["qualified_predicate"]["type"]) assert isinstance(qualified_object_aspect, edge_properties_lookup["qualified_object_aspect"]["type"]) assert isinstance(qualified_object_direction, edge_properties_lookup["qualified_object_direction"]["type"]) + assert isinstance(domain_range_exclusion, edge_properties_lookup["domain_range_exclusion"]["type"]) return { @@ -304,7 +306,8 @@ def _create_edge(subject: str, object: str, predicate: str, primary_knowledge_so "kg2_ids": kg2_ids, "qualified_predicate": qualified_predicate, "qualified_object_aspect": qualified_object_aspect, - "qualified_object_direction": qualified_object_direction + "qualified_object_direction": qualified_object_direction, + "domain_range_exclusion": domain_range_exclusion } @@ -535,6 +538,7 @@ def _canonicalize_edges(kg2pre_edges: List[Dict[str, any]], curie_map: Dict[str, edge_qualified_predicate = kg2pre_edge['qualified_predicate'] if kg2pre_edge.get('qualified_predicate') else "" edge_qualified_object_aspect = kg2pre_edge['qualified_object_aspect'] if kg2pre_edge.get('qualified_object_aspect') else "" edge_qualified_object_direction = kg2pre_edge['qualified_object_direction'] if kg2pre_edge.get('qualified_object_direction') else "" + edge_domain_range_exclusion = kg2pre_edge['domain_range_exclusion'] '''Patch for lack of qualified_predicate when qualified_object_direction is present''' predicate = kg2pre_edge['predicate'] @@ -566,7 +570,8 @@ def _canonicalize_edges(kg2pre_edges: List[Dict[str, any]], curie_map: Dict[str, kg2_ids=[kg2_edge_id], qualified_predicate=edge_qualified_predicate, qualified_object_aspect=edge_qualified_object_aspect, - qualified_object_direction=edge_qualified_object_direction) + qualified_object_direction=edge_qualified_object_direction, + domain_range_exclusion=edge_domain_range_exclusion) canonicalized_edges[canonicalized_edge_key] = new_canonicalized_edge logging.info(f"Number of KG2pre edges was reduced to {len(canonicalized_edges)} " f"({round((len(canonicalized_edges) / len(kg2pre_edges)) * 100)}%)") diff --git a/code/kg2c/kg2c_config.json b/code/kg2c/kg2c_config.json index eab9637e7..d07bc7f50 100644 --- a/code/kg2c/kg2c_config.json +++ b/code/kg2c/kg2c_config.json @@ -1,5 +1,5 @@ { - "kg2pre_version": "2.8.2", + "kg2pre_version": "2.8.4", "biolink_version": "3.1.2", "upload_to_arax_databases.rtx.ai": true, "synonymizer": {