From cd625d4f29d6d0b5c3a4e7eb796bd1a89da5817b Mon Sep 17 00:00:00 2001 From: Anthony Gitter Date: Sun, 3 Dec 2023 11:56:54 -0600 Subject: [PATCH] Remove self-edges from EGFR data --- input/README.md | 6 +- input/phosphosite-irefindex13.0-uniprot.txt | 182 -------------------- 2 files changed, 4 insertions(+), 184 deletions(-) diff --git a/input/README.md b/input/README.md index 2f1633f5..e60e650d 100644 --- a/input/README.md +++ b/input/README.md @@ -35,6 +35,7 @@ For example: A B 0.98 U B C 0.77 D ``` +or ``` A B 0.98 B C 0.77 @@ -53,7 +54,7 @@ The following files are very small toy datasets used to illustrate the supported This dataset represents protein phosphorylation changes in response to epidermal growth factor (EGF) treatment. The network includes protein-protein interactions from [iRefIndex](http://irefindex.org/) and kinase-substrate interactions from [PhosphoSitePlus](http://www.phosphosite.org/). The files are originally from the [Temporal Pathway Synthesizer (TPS)](https://github.com/koksal/tps) repository. -They have been lightly modified for SPRAS by lowering one edge weight that was greater than 1, removing a PSEUDONODE prize, and adding a prize of 10.0 to EGF_HUMAN. +They have been lightly modified for SPRAS by lowering one edge weight that was greater than 1, removing 182 self-edges, removing a PSEUDONODE prize, and adding a prize of 10.0 to EGF_HUMAN. The only source is EGF_HUMAN. All proteins with phosphorylation-based prizes are also labeled as targets. All nodes are considered active. @@ -61,7 +62,7 @@ All nodes are considered active. If you use any of the input files `tps-egfr-prizes.txt` or `phosphosite-irefindex13.0-uniprot.txt`, reference the publication [Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data](https://doi.org/10.1016/j.celrep.2018.08.085). -Ali Sinan K�ksal, Kirsten Beck, Dylan R. Cronin, Aaron McKenna, Nathan D. Camp, Saurabh Srivastava, Matthew E. MacGilvray, Rastislav Bod�k, Alejandro Wolf-Yadlin, Ernest Fraenkel, Jasmin Fisher, Anthony Gitter. +Ali Sinan Köksal, Kirsten Beck, Dylan R. Cronin, Aaron McKenna, Nathan D. Camp, Saurabh Srivastava, Matthew E. MacGilvray, Rastislav Bodík, Alejandro Wolf-Yadlin, Ernest Fraenkel, Jasmin Fisher, Anthony Gitter. *Cell Reports* 24(13):3607-3618 2018. If you use the network file `phosphosite-irefindex13.0-uniprot.txt`, also reference iRefIndex and PhosphoSitePlus. @@ -75,3 +76,4 @@ Peter V Hornbeck, Bin Zhang, Beth Murray, Jon M Kornhauser, Vaughan Latham, Elzb *Nucleic Acids Research* 43(D1):D512-520 2015. The TPS [publication](https://doi.org/10.1016/j.celrep.2018.08.085) describes how the network data and protein prizes were prepared. + diff --git a/input/phosphosite-irefindex13.0-uniprot.txt b/input/phosphosite-irefindex13.0-uniprot.txt index 3326f948..ddace9b4 100644 --- a/input/phosphosite-irefindex13.0-uniprot.txt +++ b/input/phosphosite-irefindex13.0-uniprot.txt @@ -561,7 +561,6 @@ TIE2_HUMAN GRB7_HUMAN 0.234063 U TIE2_HUMAN PTPRO_HUMAN 0.438873 U TIE2_HUMAN PTPRG_HUMAN 0.438873 U TIE2_HUMAN LCK_HUMAN 0.234063 U -TIE2_HUMAN TIE2_HUMAN 0.620000 U TIE2_HUMAN SOCS1_HUMAN 0.140780 U TIE2_HUMAN NEMO_HUMAN 0.438873 U TIE2_HUMAN P85A_HUMAN 0.140780 U @@ -935,7 +934,6 @@ KPCL_HUMAN NUMB_HUMAN 0.140780 U KPCL_HUMAN KPCD2_HUMAN 0.776667 D KPCL_HUMAN ITB2_HUMAN 0.620000 D KPCL_HUMAN PDPK1_HUMAN 0.292198 U -KPCL_HUMAN KPCL_HUMAN 0.620000 U KPCL_HUMAN HS90B_HUMAN 0.401165 U KPCL_HUMAN ARCH_HUMAN 0.367850 U KPCL_HUMAN B4DEE8_HUMAN 0.401165 U @@ -2899,7 +2897,6 @@ LYAM3_HUMAN FUT4_HUMAN 0.234063 U KPCD_HUMAN TRPV4_HUMAN 0.776667 D TRPV4_HUMAN A8K379_HUMAN 0.543520 U TRPV4_HUMAN B4DJ51_HUMAN 0.169068 U -TRPV4_HUMAN TRPV4_HUMAN 0.401165 U TRPV4_HUMAN ITCH_HUMAN 0.401165 U TRPV4_HUMAN Q5TZC3_HUMAN 0.282922 U TRPV4_HUMAN HCK_HUMAN 0.401165 U @@ -3494,7 +3491,6 @@ KC1E_HUMAN DNJA1_HUMAN 0.401165 U KC1E_HUMAN HS105_HUMAN 0.401165 U KC1E_HUMAN GFAP_HUMAN 0.401165 U KC1E_HUMAN TCTP_HUMAN 0.140780 U -KC1E_HUMAN KC1E_HUMAN 0.886667 U KC1E_HUMAN Q59H77_HUMAN 0.401165 U KC1E_HUMAN SFPQ_HUMAN 0.401165 U KI2L1_HUMAN 1C04_HUMAN 0.140780 U @@ -3592,7 +3588,6 @@ EPHA2_HUMAN GATD1_HUMAN 0.507011 U EPHA2_HUMAN IMA4_HUMAN 0.507011 U EPHA2_HUMAN EF2_HUMAN 0.345052 U EPHA2_HUMAN EGFR_HUMAN 0.140780 U -EPHA2_HUMAN EPHA2_HUMAN 0.996667 U EPHA2_HUMAN EFNA5_HUMAN 0.881427 U EPHA2_HUMAN NUDT9_HUMAN 0.367850 U EPHA2_HUMAN EFNA3_HUMAN 0.368858 U @@ -4219,7 +4214,6 @@ KS6B1_HUMAN PDIP3_HUMAN 0.840000 D KS6B1_HUMAN DPPA4_HUMAN 0.507011 U KS6B1_HUMAN HS90A_HUMAN 0.401165 U KS6B1_HUMAN IRS1_HUMAN 0.950000 D -KS6B1_HUMAN KS6B1_HUMAN 0.663333 U KS6B1_HUMAN KI3L1_HUMAN 0.367850 U NEK6_HUMAN KS6B1_HUMAN 0.666667 D KS6B1_HUMAN SQSTM_HUMAN 0.401165 U @@ -4601,7 +4595,6 @@ VRK1_HUMAN JUN_HUMAN 0.840000 D VRK1_HUMAN VIME_HUMAN 0.401165 U VRK1_HUMAN RS29_HUMAN 0.401165 U VRK1_HUMAN J3KQN4_HUMAN 0.401165 U -VRK1_HUMAN VRK1_HUMAN 0.553333 U VRK1_HUMAN RL23A_HUMAN 0.401165 U VRK1_HUMAN A8K5I0_HUMAN 0.401165 U VRK1_HUMAN ATF2_HUMAN 0.840000 D @@ -11708,7 +11701,6 @@ IGF1R_HUMAN MDM2_HUMAN 0.750059 U IGF1R_HUMAN A7UKX8_HUMAN 0.234063 U IGF1R_HUMAN CAV1_HUMAN 0.140780 U IGF1R_HUMAN GNAI2_HUMAN 0.261094 U -IGF1R_HUMAN IGF1R_HUMAN 0.996667 U IGF1R_HUMAN 1433E_HUMAN 0.786912 U IGF1R_HUMAN TAGL_HUMAN 0.401165 U IGF1R_HUMAN ARRB2_HUMAN 0.701756 U @@ -12519,7 +12511,6 @@ INSR_HUMAN TEAD1_HUMAN 0.367850 U INSR_HUMAN HNRPQ_HUMAN 0.140780 U INSR_HUMAN JAK1_HUMAN 0.378760 U INSR_HUMAN CYH2_HUMAN 0.401165 U -INSR_HUMAN INSR_HUMAN 0.776667 U INSR_HUMAN DOK1_HUMAN 0.620000 D INSR_HUMAN PTPRF_HUMAN 0.234063 U KPCA_HUMAN INSR_HUMAN 0.620000 D @@ -13928,7 +13919,6 @@ KSYK_HUMAN K7ENL3_HUMAN 0.140780 U KSYK_HUMAN E6Y0F1_HUMAN 0.401165 U KSYK_HUMAN PHAG1_HUMAN 0.526940 U KSYK_HUMAN TLR4_HUMAN 0.401165 U -KSYK_HUMAN KSYK_HUMAN 0.700000 U KSYK_HUMAN CLC1B_HUMAN 0.272209 U KSYK_HUMAN B4DJW8_HUMAN 0.401165 U KSYK_HUMAN FCERA_HUMAN 0.401165 U @@ -16408,7 +16398,6 @@ ERBB2_HUMAN CBL_HUMAN 0.269735 U ERBB2_HUMAN Q71V34_HUMAN 0.234063 U ERBB2_HUMAN A6ZID6_HUMAN 0.628096 U ERBB2_HUMAN VAV2_HUMAN 0.526940 U -ERBB2_HUMAN ERBB2_HUMAN 0.996667 U ERBB2_HUMAN TOB1_HUMAN 0.234063 U ERBB2_HUMAN SH22A_HUMAN 0.526940 U ERBB2_HUMAN BLNK_HUMAN 0.526940 U @@ -17673,7 +17662,6 @@ LRRK2_HUMAN B5B2P3_HUMAN 0.401165 U LRRK2_HUMAN RIPK1_HUMAN 0.401165 U LRRK2_HUMAN AKT1_HUMAN 0.773333 D LRRK2_HUMAN PRKN2_HUMAN 0.401165 U -LRRK2_HUMAN LRRK2_HUMAN 0.996667 U LRRK2_HUMAN LRRK1_HUMAN 0.589229 U LRRK2_HUMAN MOES_HUMAN 0.553333 D LRRK2_HUMAN RADI_HUMAN 0.553333 D @@ -23611,7 +23599,6 @@ FES_HUMAN BCR_HUMAN 0.553333 D FES_HUMAN RASA1_HUMAN 0.234063 U FES_HUMAN ELF1_HUMAN 0.401165 U FES_HUMAN MYOME_HUMAN 0.367850 U -FES_HUMAN FES_HUMAN 0.840000 U TFCP2_HUMAN SYT1_HUMAN 0.401165 U TFCP2_HUMAN SIN3A_HUMAN 0.438873 U TFCP2_HUMAN PAXI_HUMAN 0.378760 U @@ -24737,7 +24724,6 @@ MUC1_HUMAN GALT2_HUMAN 0.234063 U SRC_HUMAN MUC1_HUMAN 0.553333 D MUC1_HUMAN K7PPA8_HUMAN 0.347780 U MUC1_HUMAN EGFR_HUMAN 0.782776 U -MUC1_HUMAN MUC1_HUMAN 0.524233 U MUC1_HUMAN NEMO_HUMAN 0.272209 U MUC1_HUMAN D0VY79_HUMAN 0.401165 U MUC1_HUMAN LYN_HUMAN 0.401165 U @@ -27070,7 +27056,6 @@ BIEA_HUMAN MK01_HUMAN 0.401165 U BIEA_HUMAN SUMO2_HUMAN 0.401165 U BIEA_HUMAN KPCB_HUMAN 0.773333 D MK03_HUMAN BIEA_HUMAN 0.553333 D -BIEA_HUMAN BIEA_HUMAN 0.620000 U BIEA_HUMAN KPCZ_HUMAN 0.558037 U BIEA_HUMAN L7RXH5_HUMAN 0.438873 U BIEA_HUMAN A4QPA9_HUMAN 0.401165 U @@ -28232,7 +28217,6 @@ PAK7_HUMAN HIG1A_HUMAN 0.401165 U PAK7_HUMAN B4E1U9_HUMAN 0.750035 U PAK7_HUMAN A4D2P1_HUMAN 0.140780 U PAK7_HUMAN PDLI7_HUMAN 0.405558 U -PAK7_HUMAN PAK7_HUMAN 0.663333 U PAK7_HUMAN S10A7_HUMAN 0.524233 U PAK7_HUMAN GCP4_HUMAN 0.469622 U M0R2R2_HUMAN F1D8Q5_HUMAN 0.405558 U @@ -31384,7 +31368,6 @@ MCL1_HUMAN B2L11_HUMAN 0.906983 U MCL1_HUMAN BIK_HUMAN 0.699249 U MCL1_HUMAN A8K5I0_HUMAN 0.401165 U MCL1_HUMAN BCL2_HUMAN 0.140780 U -MCL1_HUMAN MCL1_HUMAN 0.345052 U MCL1_HUMAN HRK_HUMAN 0.520886 U MCL1_HUMAN ATG12_HUMAN 0.401165 U MCL1_HUMAN COX41_HUMAN 0.345052 U @@ -34063,7 +34046,6 @@ KGP1_HUMAN G5E9C5_HUMAN 0.140780 U KGP1_HUMAN Q59H91_HUMAN 0.169068 U KGP1_HUMAN PPR17_HUMAN 0.140780 U KGP1_HUMAN MERL_HUMAN 0.140780 U -KGP1_HUMAN KGP1_HUMAN 0.886667 U KGP1_HUMAN SMAD4_HUMAN 0.401165 U KGP1_HUMAN CREB1_HUMAN 0.287660 U KGP1_HUMAN TA2R_HUMAN 0.620000 D @@ -34241,7 +34223,6 @@ ZAP70_HUMAN APC11_HUMAN 0.367850 U ZAP70_HUMAN CBLB_HUMAN 0.140780 U ZAP70_HUMAN NR0B2_HUMAN 0.367850 U ZAP70_HUMAN SLAF6_HUMAN 0.169068 U -ZAP70_HUMAN ZAP70_HUMAN 0.950000 U ZAP70_HUMAN 3BP2_HUMAN 0.234063 U ZAP70_HUMAN L7RT18_HUMAN 0.642437 U ZAP70_HUMAN G5E9K3_HUMAN 0.169068 U @@ -34775,7 +34756,6 @@ HCK_HUMAN GPVI_HUMAN 0.401165 U HCK_HUMAN NUCL_HUMAN 0.401165 U HCK_HUMAN CCR3_HUMAN 0.401165 U HCK_HUMAN PK3CB_HUMAN 0.479927 U -HCK_HUMAN HCK_HUMAN 0.620000 U HCK_HUMAN FCG2A_HUMAN 0.234063 U HCK_HUMAN RASA3_HUMAN 0.543520 U HCK_HUMAN DYN2_HUMAN 0.401165 U @@ -36895,7 +36875,6 @@ TENS1_HUMAN D0PNI1_HUMAN 0.405558 U PTK6_HUMAN STAP2_HUMAN 0.663333 D PTK6_HUMAN PAXI_HUMAN 0.730000 D PTK6_HUMAN Q2TA81_HUMAN 0.309917 U -PTK6_HUMAN PTK6_HUMAN 0.620000 U PTK6_HUMAN BCAR1_HUMAN 0.840000 D PTK6_HUMAN ERBB3_HUMAN 0.584182 U PTK6_HUMAN AKT1_HUMAN 0.840000 D @@ -37835,7 +37814,6 @@ TYK2_HUMAN LYN_HUMAN 0.493320 U TYK2_HUMAN Q8IW76_HUMAN 0.543520 U TYK2_HUMAN VAV_HUMAN 0.493320 U TYK2_HUMAN JAK3_HUMAN 0.524233 U -TYK2_HUMAN TYK2_HUMAN 0.620000 U TYK2_HUMAN CSN5_HUMAN 0.527246 U TYK2_HUMAN PGFRB_HUMAN 0.234063 U TYK2_HUMAN INAR1_HUMAN 0.620000 D @@ -41013,7 +40991,6 @@ TBK1_HUMAN K9JA46_HUMAN 0.493320 U TBK1_HUMAN Q9UQC1_HUMAN 0.493320 U TBK1_HUMAN RUVB1_HUMAN 0.493320 U TBK1_HUMAN DDX58_HUMAN 0.401165 U -TBK1_HUMAN TBK1_HUMAN 0.663333 U TBK1_HUMAN Q53T26_HUMAN 0.438873 U TBK1_HUMAN G8JLE9_HUMAN 0.401165 U TBK1_HUMAN UBC_HUMAN 0.401165 U @@ -41377,7 +41354,6 @@ FGFR3_HUMAN FGF17_HUMAN 0.140780 U FGFR3_HUMAN FAK2_HUMAN 0.169068 U FGFR3_HUMAN CCD17_HUMAN 0.367850 U FGFR3_HUMAN FGF3_HUMAN 0.140780 U -FGFR3_HUMAN FGFR3_HUMAN 0.776667 U FGFR3_HUMAN FGF4_HUMAN 0.479927 U FGFR3_HUMAN NDUS6_HUMAN 0.447879 U FGFR3_HUMAN GRB2_HUMAN 0.140780 U @@ -41474,7 +41450,6 @@ CSKP_HUMAN UIMC1_HUMAN 0.401165 U CSKP_HUMAN DUS3_HUMAN 0.507011 U CSKP_HUMAN IRK12_HUMAN 0.643744 U CSKP_HUMAN I15RA_HUMAN 0.367850 U -CSKP_HUMAN CSKP_HUMAN 0.620000 U CSKP_HUMAN Q29RX4_HUMAN 0.438873 U CSKP_HUMAN RP3A_HUMAN 0.658234 U CSKP_HUMAN EPS8_HUMAN 0.524233 U @@ -42359,7 +42334,6 @@ CASP8_HUMAN CASP9_HUMAN 0.623033 U CASP8_HUMAN HIP1_HUMAN 0.401165 U CASP8_HUMAN RHOA_HUMAN 0.345052 U CASP8_HUMAN FADD_HUMAN 0.979843 U -CASP8_HUMAN CASP8_HUMAN 0.497553 U CASP8_HUMAN VIME_HUMAN 0.447879 U CASP8_HUMAN GDIR1_HUMAN 0.345052 U CASP8_HUMAN TRAF6_HUMAN 0.667063 U @@ -47107,7 +47081,6 @@ KS6A1_HUMAN VIME_HUMAN 0.401165 U KS6A1_HUMAN YBOX1_HUMAN 0.773333 D KS6A1_HUMAN PARP1_HUMAN 0.401165 U KS6A1_HUMAN TCPH_HUMAN 0.401165 U -KS6A1_HUMAN KS6A1_HUMAN 0.553333 U KS6A1_HUMAN D1MGQ2_HUMAN 0.401165 U KS6A1_HUMAN COR1C_HUMAN 0.401165 U KS6A1_HUMAN TBB5_HUMAN 0.401165 U @@ -49166,7 +49139,6 @@ SRPK1_HUMAN OR6B3_HUMAN 0.438873 U SRPK1_HUMAN SRSF8_HUMAN 0.438873 U SRPK1_HUMAN LC7L2_HUMAN 0.438873 U SRPK1_HUMAN MAPK5_HUMAN 0.438873 U -SRPK1_HUMAN SRPK1_HUMAN 0.920000 U SRPK1_HUMAN RBM8A_HUMAN 0.620000 D SRPK1_HUMAN ZN514_HUMAN 0.438873 U SRPK1_HUMAN PEX19_HUMAN 0.507011 U @@ -49377,7 +49349,6 @@ BRAF_HUMAN TIM50_HUMAN 0.367850 U BRAF_HUMAN RASH_HUMAN 0.660090 U BRAF_HUMAN MP2K1_HUMAN 0.840000 D BRAF_HUMAN HS90B_HUMAN 0.589229 U -BRAF_HUMAN BRAF_HUMAN 0.553333 U BRAF_HUMAN L7RSL8_HUMAN 0.140780 U BRAF_HUMAN RPGP1_HUMAN 0.438873 U BRAF_HUMAN 1433S_HUMAN 0.524233 U @@ -49983,7 +49954,6 @@ CUBN_HUMAN VTDB_HUMAN 0.428324 U KS6B2_HUMAN EF2K_HUMAN 0.553333 D MK11_HUMAN EF2K_HUMAN 0.553333 D MK13_HUMAN EF2K_HUMAN 0.840000 D -EF2K_HUMAN EF2K_HUMAN 0.866667 U AAPK1_HUMAN EF2K_HUMAN 0.773333 D TRPM7_HUMAN EF2K_HUMAN 0.553333 D MAPK2_HUMAN EF2K_HUMAN 0.663333 D @@ -50618,7 +50588,6 @@ PAK1_HUMAN PAXI_HUMAN 0.773333 D PAK1_HUMAN TBCB_HUMAN 0.840000 D PAK1_HUMAN K9JA46_HUMAN 0.367850 U PAK1_HUMAN LIMK1_HUMAN 0.553333 D -PAK1_HUMAN PAK1_HUMAN 0.666667 U PAK1_HUMAN EXOC3_HUMAN 0.140780 U PAK1_HUMAN CD11B_HUMAN 0.690370 U PAK1_HUMAN RAF1_HUMAN 0.840000 D @@ -51582,7 +51551,6 @@ KPCE_HUMAN CREB1_HUMAN 0.663333 D KPCE_HUMAN RB11A_HUMAN 0.553333 D GSK3B_HUMAN KPCE_HUMAN 0.773333 D KPCE_HUMAN ADAP1_HUMAN 0.620000 D -KPCE_HUMAN KPCE_HUMAN 0.920000 U KPCE_HUMAN TNNI3_HUMAN 0.553333 D KPCE_HUMAN KPCD1_HUMAN 0.620000 D MK11_HUMAN KPCE_HUMAN 0.553333 D @@ -56777,7 +56745,6 @@ EGLN_HUMAN ITA5_HUMAN 0.556019 U EGLN_HUMAN D3DPA4_HUMAN 0.234063 U EGLN_HUMAN GIPC1_HUMAN 0.401165 U EGLN_HUMAN EGR1_HUMAN 0.401165 U -EGLN_HUMAN EGLN_HUMAN 0.140780 U EGLN_HUMAN A8K571_HUMAN 0.140780 U TGFR2_HUMAN EGLN_HUMAN 0.730000 D EGLN_HUMAN D0VY79_HUMAN 0.401165 U @@ -58156,7 +58123,6 @@ RIPK1_HUMAN TAB2_HUMAN 0.701756 U RIPK1_HUMAN TBA3C_HUMAN 0.493320 U RIPK1_HUMAN KC1A_HUMAN 0.602067 U RIPK1_HUMAN TRAF1_HUMAN 0.607489 U -RIPK1_HUMAN RIPK1_HUMAN 0.730000 U RIPK1_HUMAN K9JA46_HUMAN 0.552475 U RIPK1_HUMAN Q9UQC1_HUMAN 0.493320 U RIPK1_HUMAN TIM50_HUMAN 0.493320 U @@ -58663,7 +58629,6 @@ FA7_HUMAN TF_HUMAN 0.801045 U FA7_HUMAN FA10_HUMAN 0.140780 U FA7_HUMAN TFPI1_HUMAN 0.140780 U FA7_HUMAN NEMO_HUMAN 0.479927 U -FA7_HUMAN FA7_HUMAN 0.533322 U FA7_HUMAN HEPS_HUMAN 0.140780 U FA7_HUMAN FA9_HUMAN 0.234063 U FA7_HUMAN ALBU_HUMAN 0.140780 U @@ -58712,7 +58677,6 @@ TPP2_HUMAN UBD_HUMAN 0.401165 U TPP2_HUMAN CDK2_HUMAN 0.401165 U UAP1_HUMAN VPS39_HUMAN 0.345052 U UAP1_HUMAN VP37C_HUMAN 0.401165 U -UAP1_HUMAN UAP1_HUMAN 0.292198 U UAP1_HUMAN AP3B1_HUMAN 0.140780 U UAP1_HUMAN B2R532_HUMAN 0.140780 U UAP1_HUMAN THOP1_HUMAN 0.345052 U @@ -59001,7 +58965,6 @@ GREM2_HUMAN C8C060_HUMAN 0.140780 U GREM2_HUMAN STK3_HUMAN 0.401165 U ITK_HUMAN CBL_HUMAN 0.538067 U ITK_HUMAN ABI1_HUMAN 0.438873 U -ITK_HUMAN ITK_HUMAN 0.553333 U ITK_HUMAN BLNK_HUMAN 0.140780 U ITK_HUMAN SRC_HUMAN 0.438873 U ITK_HUMAN CD2_HUMAN 0.401165 U @@ -62174,7 +62137,6 @@ CSK21_HUMAN RBM10_HUMAN 0.438873 U CSK21_HUMAN B2RTR1_HUMAN 0.438873 U CSK21_HUMAN F1D8P8_HUMAN 0.140780 U CSK21_HUMAN AQP4_HUMAN 0.140780 U -CSK21_HUMAN CSK21_HUMAN 0.553333 U CSK21_HUMAN SRS11_HUMAN 0.438873 U CSK21_HUMAN KPCZ_HUMAN 0.543520 U CSK21_HUMAN HMGA2_HUMAN 0.140780 U @@ -62975,7 +62937,6 @@ KAPCA_HUMAN IRK3_HUMAN 0.773333 D KAPCA_HUMAN SRF_HUMAN 0.773333 D KAPCA_HUMAN MCLN1_HUMAN 0.840000 D KAPCA_HUMAN GFAP_HUMAN 0.700000 D -KAPCA_HUMAN KAPCA_HUMAN 0.553333 U KAPCA_HUMAN RGRF1_HUMAN 0.773333 D KAPCA_HUMAN AURKA_HUMAN 0.553333 D KAPCA_HUMAN TITIN_HUMAN 0.553333 D @@ -64646,7 +64607,6 @@ TERF1_HUMAN ST1C2_HUMAN 0.405558 U TERF1_HUMAN TNKS2_HUMAN 0.819241 U TERF1_HUMAN NUMA1_HUMAN 0.405558 U TERF1_HUMAN UTRO_HUMAN 0.401165 U -TERF1_HUMAN TERF1_HUMAN 0.527469 U TERF1_HUMAN FBX4_HUMAN 0.899628 U TERF1_HUMAN FACD2_HUMAN 0.554041 U TERF1_HUMAN MT1X_HUMAN 0.405558 U @@ -64761,7 +64721,6 @@ PASK_HUMAN PIAS1_HUMAN 0.438873 U PASK_HUMAN GYS1_HUMAN 0.438873 U PASK_HUMAN FRDA_HUMAN 0.438873 U PASK_HUMAN CREB1_HUMAN 0.558037 U -PASK_HUMAN PASK_HUMAN 0.620000 U PASK_HUMAN RFIP1_HUMAN 0.438873 U PASK_HUMAN NCF1_HUMAN 0.438873 U PASK_HUMAN IL2RA_HUMAN 0.438873 U @@ -65488,7 +65447,6 @@ STK24_HUMAN CRCM_HUMAN 0.401165 U STK24_HUMAN ENPL_HUMAN 0.140780 U STK24_HUMAN PSDE_HUMAN 0.140780 U STK24_HUMAN CETN3_HUMAN 0.140780 U -STK24_HUMAN STK24_HUMAN 0.773333 U STK24_HUMAN A8K7B7_HUMAN 0.401165 U STK24_HUMAN DDX5_HUMAN 0.401165 U STK24_HUMAN A8K2M0_HUMAN 0.140780 U @@ -66073,7 +66031,6 @@ CHK2_HUMAN VATD_HUMAN 0.140780 U CHK2_HUMAN MPIP1_HUMAN 0.920000 D CHK2_HUMAN PSME3_HUMAN 0.401165 U CHK2_HUMAN F5GXF0_HUMAN 0.405558 U -CHK2_HUMAN CHK2_HUMAN 0.996667 U CHK2_HUMAN ATAD2_HUMAN 0.140780 U CHK2_HUMAN IMB1_HUMAN 0.140780 U CHK2_HUMAN OAT_HUMAN 0.140780 U @@ -68812,7 +68769,6 @@ KPCD2_HUMAN F1D8Q5_HUMAN 0.447879 U KPCD2_HUMAN MARK2_HUMAN 0.663333 D KPCD2_HUMAN HDAC5_HUMAN 0.553333 D KPCD2_HUMAN MYH9_HUMAN 0.267760 U -KPCD2_HUMAN KPCD2_HUMAN 0.553333 U KPCD2_HUMAN PI4KB_HUMAN 0.773333 D KPCD2_HUMAN GRIP1_HUMAN 0.447879 U KPCD2_HUMAN GLRX3_HUMAN 0.447879 U @@ -69466,7 +69422,6 @@ KPCB_HUMAN KPCD_HUMAN 0.401165 U KPCB_HUMAN RB_HUMAN 0.461944 U KPCB_HUMAN SDC2_HUMAN 0.450549 U KPCB_HUMAN PHLP1_HUMAN 0.581563 U -KPCB_HUMAN KPCB_HUMAN 0.840000 U KPCB_HUMAN CRCM1_HUMAN 0.840000 D KPCB_HUMAN TOP2A_HUMAN 0.526940 U KPCB_HUMAN PP2AB_HUMAN 0.140780 U @@ -69803,7 +69758,6 @@ AURKA_HUMAN CDC20_HUMAN 0.140780 U AURKA_HUMAN MAP9_HUMAN 0.840000 D AURKA_HUMAN MARE3_HUMAN 0.773333 D AURKA_HUMAN IKKB_HUMAN 0.558037 U -AURKA_HUMAN AURKA_HUMAN 0.996667 U AURKA_HUMAN H31_HUMAN 0.773333 D AURKA_HUMAN WRN_HUMAN 0.140780 U AURKA_HUMAN HNRPK_HUMAN 0.524233 U @@ -70920,7 +70874,6 @@ MTOR_HUMAN PROP_HUMAN 0.438873 U MTOR_HUMAN FKBP8_HUMAN 0.401165 U MTOR_HUMAN FKB1A_HUMAN 0.805358 U MTOR_HUMAN 4EBP2_HUMAN 0.438873 U -MTOR_HUMAN MTOR_HUMAN 0.950000 U MTOR_HUMAN D0PNI1_HUMAN 0.524233 U MTOR_HUMAN WNK1_HUMAN 0.663333 D MTOR_HUMAN RPTOR_HUMAN 0.840000 D @@ -75815,7 +75768,6 @@ GRK6_HUMAN ITA5_HUMAN 0.405558 U GRK6_HUMAN EDNRB_HUMAN 0.140780 U GRK6_HUMAN FSHR_HUMAN 0.140780 U GRK6_HUMAN GIT1_HUMAN 0.140780 U -GRK6_HUMAN GRK6_HUMAN 0.730000 U GRK6_HUMAN NHRF1_HUMAN 0.169068 U GRK6_HUMAN BKRB2_HUMAN 0.169068 U GRK6_HUMAN SYUG_HUMAN 0.438873 U @@ -76320,7 +76272,6 @@ PDPK1_HUMAN BLMH_HUMAN 0.405558 U PDPK1_HUMAN SNF5_HUMAN 0.367850 U PDPK1_HUMAN A4_HUMAN 0.438873 U PDPK1_HUMAN PPT1_HUMAN 0.140780 U -PDPK1_HUMAN PDPK1_HUMAN 0.976667 U PDPK1_HUMAN KS6A3_HUMAN 0.414931 U PDPK1_HUMAN B0LPE5_HUMAN 0.799961 U PDPK1_HUMAN PKN2_HUMAN 0.663333 D @@ -76467,7 +76418,6 @@ PINK1_HUMAN B0LPE5_HUMAN 0.401165 U PINK1_HUMAN NEDD8_HUMAN 0.401165 U PINK1_HUMAN TBB5_HUMAN 0.401165 U PINK1_HUMAN M3K7_HUMAN 0.543520 U -PINK1_HUMAN PINK1_HUMAN 0.776667 U PINK1_HUMAN HSP74_HUMAN 0.589229 U PINK1_HUMAN HTRA2_HUMAN 0.401165 U PINK1_HUMAN SARM1_HUMAN 0.401165 U @@ -76549,7 +76499,6 @@ PGFRA_HUMAN L7RT18_HUMAN 0.793014 U PGFRA_HUMAN F6KD01_HUMAN 0.401165 U PGFRA_HUMAN CAV1_HUMAN 0.140780 U PGFRB_HUMAN PGFRA_HUMAN 0.553333 D -PGFRA_HUMAN PGFRA_HUMAN 0.810000 U PGFRA_HUMAN GRB2_HUMAN 0.589229 U KIRR3_HUMAN PODO_HUMAN 0.261094 U KIRR3_HUMAN INMT_HUMAN 0.140780 U @@ -77443,7 +77392,6 @@ ERBB4_HUMAN ANS1B_HUMAN 0.438873 U ERBB4_HUMAN HS90B_HUMAN 0.524233 U ERBB4_HUMAN ABL2_HUMAN 0.515545 U ERBB4_HUMAN B2RNB2_HUMAN 0.140780 U -ERBB4_HUMAN ERBB4_HUMAN 0.553333 U ERBB4_HUMAN STA5B_HUMAN 0.470512 U ERBB4_HUMAN PTN11_HUMAN 0.470512 U ERBB4_HUMAN SNTB2_HUMAN 0.536080 U @@ -78801,7 +78749,6 @@ STK4_HUMAN Q96FU2_HUMAN 0.401165 U STK4_HUMAN PSA2_HUMAN 0.401165 U STK4_HUMAN B2R6Q4_HUMAN 0.401165 U STK4_HUMAN RLA2_HUMAN 0.401165 U -STK4_HUMAN STK4_HUMAN 0.663333 U STK4_HUMAN DCD_HUMAN 0.401165 U STK4_HUMAN RASF6_HUMAN 0.507959 U STK4_HUMAN RS26_HUMAN 0.401165 U @@ -79279,7 +79226,6 @@ PRRX2_HUMAN SOX10_HUMAN 0.236421 U FGFR2_HUMAN STA5A_HUMAN 0.401165 U FGFR2_HUMAN CBL_HUMAN 0.401165 U FGFR2_HUMAN C7FDY0_HUMAN 0.669360 U -FGFR2_HUMAN FGFR2_HUMAN 0.553333 U FGFR2_HUMAN FGF2_HUMAN 0.824943 U FGFR2_HUMAN FGF23_HUMAN 0.140780 U FGFR2_HUMAN CTGF_HUMAN 0.438873 U @@ -79681,7 +79627,6 @@ CRP_HUMAN FINC_HUMAN 0.140780 U SEPP1_HUMAN EGFR_HUMAN 0.367850 U MP2K3_HUMAN MK14_HUMAN 0.840000 D MP2K3_HUMAN MK03_HUMAN 0.140780 U -MP2K3_HUMAN MP2K3_HUMAN 0.620000 U MP2K3_HUMAN Q7Z3W2_HUMAN 0.140780 U M3K5_HUMAN MP2K3_HUMAN 0.553333 D MP2K3_HUMAN SMAD4_HUMAN 0.140780 U @@ -82316,7 +82261,6 @@ NDKB_HUMAN LSM2_HUMAN 0.401165 U NDKB_HUMAN MYO5A_HUMAN 0.140780 U NDKB_HUMAN RAB5A_HUMAN 0.405558 U NDKB_HUMAN TALDO_HUMAN 0.401165 U -NDKB_HUMAN NDKB_HUMAN 0.553333 U NDKB_HUMAN COF1_HUMAN 0.140780 U NDKB_HUMAN Q9BU08_HUMAN 0.140780 U NDKB_HUMAN PUR9_HUMAN 0.401165 U @@ -83898,7 +83842,6 @@ M3K6_HUMAN M3K5_HUMAN 0.802972 U M3K6_HUMAN 1433E_HUMAN 0.401165 U M3K6_HUMAN HS90B_HUMAN 0.401165 U M3K6_HUMAN 1433T_HUMAN 0.401165 U -M3K6_HUMAN M3K6_HUMAN 0.773333 U M3K6_HUMAN AAPK2_HUMAN 0.401165 U M3K6_HUMAN 1433S_HUMAN 0.401165 U M3K6_HUMAN D0PNI1_HUMAN 0.401165 U @@ -85045,7 +84988,6 @@ SRC_HUMAN CXB1_HUMAN 0.313764 U SRC_HUMAN TRIPB_HUMAN 0.401165 U SRC_HUMAN RAC1_HUMAN 0.553333 D SRC_HUMAN TENS3_HUMAN 0.886667 D -SRC_HUMAN SRC_HUMAN 0.886667 U SRC_HUMAN SRCN1_HUMAN 0.543520 U SRC_HUMAN KS6B2_HUMAN 0.773333 D SRC_HUMAN KPCI_HUMAN 0.169068 U @@ -87806,7 +87748,6 @@ IFNG_HUMAN B4DQB3_HUMAN 0.438873 U IFNG_HUMAN PDIA3_HUMAN 0.261094 U IRAK4_HUMAN MYD88_HUMAN 0.893368 U IRAK4_HUMAN B4E0I3_HUMAN 0.401165 U -IRAK4_HUMAN IRAK4_HUMAN 0.996667 U IRAK4_HUMAN IRAK1_HUMAN 0.620000 D IRAK4_HUMAN IRAK3_HUMAN 0.401165 U IRAK4_HUMAN SASH1_HUMAN 0.401165 U @@ -90189,7 +90130,6 @@ IF16_HUMAN BRCA1_HUMAN 0.556019 U IF16_HUMAN ID1_HUMAN 0.169068 U IF16_HUMAN STING_HUMAN 0.524233 U IF16_HUMAN F1D8N5_HUMAN 0.169068 U -IF16_HUMAN IF16_HUMAN 0.401165 U IF16_HUMAN SP1_HUMAN 0.401165 U IF16_HUMAN E2F1_HUMAN 0.401165 U IF16_HUMAN TPR_HUMAN 0.260150 U @@ -91000,7 +90940,6 @@ JAK2_HUMAN STAT1_HUMAN 0.663333 D JAK2_HUMAN ELP2_HUMAN 0.401165 U JAK2_HUMAN YES_HUMAN 0.519065 U JAK2_HUMAN BRCA1_HUMAN 0.479927 U -JAK2_HUMAN JAK2_HUMAN 0.886667 U JAK2_HUMAN KIT_HUMAN 0.539435 U JAK2_HUMAN STAM1_HUMAN 0.630420 U JAK2_HUMAN IL4RA_HUMAN 0.401165 U @@ -92318,7 +92257,6 @@ KIT_HUMAN PTPRU_HUMAN 0.401165 U KIT_HUMAN F1T0G6_HUMAN 0.623033 U KIT_HUMAN STAP1_HUMAN 0.282922 U KIT_HUMAN DOK1_HUMAN 0.169068 U -KIT_HUMAN KIT_HUMAN 0.776667 U KIT_HUMAN B0LPF3_HUMAN 0.849582 U KIT_HUMAN RASA1_HUMAN 0.140780 U KIT_HUMAN PTPRO_HUMAN 0.401165 U @@ -92401,7 +92339,6 @@ RET_HUMAN CBL_HUMAN 0.795067 U RET_HUMAN GOGA5_HUMAN 0.140780 U RET_HUMAN AKT1_HUMAN 0.773333 D RET_HUMAN PLCG1_HUMAN 0.553333 D -RET_HUMAN RET_HUMAN 0.996667 U RET_HUMAN MK09_HUMAN 0.553333 D RET_HUMAN MK03_HUMAN 0.553333 D RET_HUMAN G3V1Q1_HUMAN 0.236421 U @@ -93399,7 +93336,6 @@ B2RCW4_HUMAN PPARG_HUMAN 0.405558 U B2RCW4_HUMAN CHD7_HUMAN 0.401165 U S35A2_HUMAN MDFI_HUMAN 0.447879 U S35A2_HUMAN LIMK1_HUMAN 0.140780 U -S35A2_HUMAN S35A2_HUMAN 0.401165 U S35A2_HUMAN CGT_HUMAN 0.234063 U S35A2_HUMAN S35A3_HUMAN 0.524233 U S35A2_HUMAN STAB2_HUMAN 0.140780 U @@ -93751,7 +93687,6 @@ NDKA_HUMAN IDHC_HUMAN 0.401165 U NDKA_HUMAN THOP1_HUMAN 0.401165 U NDKA_HUMAN DCUP_HUMAN 0.345052 U NDKA_HUMAN RBBP7_HUMAN 0.401165 U -NDKA_HUMAN NDKA_HUMAN 0.886667 U NDKA_HUMAN Q58EY0_HUMAN 0.548979 U NDKA_HUMAN CHRC1_HUMAN 0.401165 U NDKA_HUMAN MCF2_HUMAN 0.611341 U @@ -93838,7 +93773,6 @@ E2AK2_HUMAN STAU2_HUMAN 0.401165 U E2AK2_HUMAN DICER_HUMAN 0.401165 U E2AK2_HUMAN CDK1_HUMAN 0.773333 D E2AK2_HUMAN PGFRB_HUMAN 0.234063 U -E2AK2_HUMAN E2AK2_HUMAN 0.996667 U E2AK2_HUMAN Q6FIE9_HUMAN 0.401165 U RPC3_HUMAN RPC8_HUMAN 0.563535 U RPC3_HUMAN TF3C4_HUMAN 0.623245 U @@ -95213,7 +95147,6 @@ RASF1_HUMAN ID1_HUMAN 0.401165 U RASF1_HUMAN TBB1_HUMAN 0.267760 U RASF1_HUMAN NUD10_HUMAN 0.447879 U RASF1_HUMAN LATS1_HUMAN 0.401165 U -RASF1_HUMAN RASF1_HUMAN 0.401165 U RASF1_HUMAN Q53GM7_HUMAN 0.557230 U RASF1_HUMAN HUWE1_HUMAN 0.401165 U RASF1_HUMAN GBRL2_HUMAN 0.543520 U @@ -95656,7 +95589,6 @@ GSK3B_HUMAN DDX20_HUMAN 0.524233 U GSK3B_HUMAN RU17_HUMAN 0.524233 U GSK3B_HUMAN IF2B1_HUMAN 0.401165 U GSK3B_HUMAN JUNB_HUMAN 0.730000 D -GSK3B_HUMAN GSK3B_HUMAN 0.840000 U GSK3B_HUMAN TAZ_HUMAN 0.543520 U GSK3B_HUMAN DNMT1_HUMAN 0.507011 U GSK3B_HUMAN NSF1C_HUMAN 0.405558 U @@ -96194,7 +96126,6 @@ CHK1_HUMAN K9JA46_HUMAN 0.140780 U CHK1_HUMAN MPIP1_HUMAN 0.976667 D CHK1_HUMAN MPIP3_HUMAN 0.553333 D CHK1_HUMAN FACD2_HUMAN 0.773333 D -CHK1_HUMAN CHK1_HUMAN 0.553333 U CHK1_HUMAN NEK11_HUMAN 0.773333 D CHK1_HUMAN TAU_HUMAN 0.553333 D CHK1_HUMAN AURKB_HUMAN 0.773333 D @@ -97485,7 +97416,6 @@ M3K5_HUMAN GSTM1_HUMAN 0.234063 U M3K5_HUMAN TRAF1_HUMAN 0.401165 U M3K5_HUMAN B4DP61_HUMAN 0.401165 U M3K5_HUMAN KCC2D_HUMAN 0.140780 U -M3K5_HUMAN M3K5_HUMAN 0.700000 U M3K5_HUMAN SYQ_HUMAN 0.506360 U M3K5_HUMAN MP2K6_HUMAN 0.553333 D M3K5_HUMAN 1433S_HUMAN 0.367850 U @@ -97942,7 +97872,6 @@ FAK2_HUMAN PTN6_HUMAN 0.677583 U FAK2_HUMAN MBD2_HUMAN 0.601642 U FAK2_HUMAN DLG4_HUMAN 0.234063 U FAK2_HUMAN GELS_HUMAN 0.234063 U -FAK2_HUMAN FAK2_HUMAN 0.663333 U FAK2_HUMAN F6KD01_HUMAN 0.401165 U FAK2_HUMAN GP1BB_HUMAN 0.401165 U FAK2_HUMAN VAV_HUMAN 0.548937 U @@ -98552,7 +98481,6 @@ WNK1_HUMAN D0PNI1_HUMAN 0.367850 U WNK1_HUMAN SIMC1_HUMAN 0.367850 U WNK1_HUMAN RMD3_HUMAN 0.367850 U WNK1_HUMAN ZEP2_HUMAN 0.367850 U -WNK1_HUMAN WNK1_HUMAN 0.553333 U WNK1_HUMAN WNK2_HUMAN 0.367850 U WNK1_HUMAN TNAP3_HUMAN 0.367850 U WNK1_HUMAN RPGP2_HUMAN 0.367850 U @@ -100650,7 +100578,6 @@ GBB2_HUMAN GBG7_HUMAN 0.764863 U GBB2_HUMAN GBG1_HUMAN 0.547059 U GBB2_HUMAN GBG13_HUMAN 0.169068 U MK15_HUMAN CLIC3_HUMAN 0.414931 U -MK15_HUMAN MK15_HUMAN 0.996667 U MK15_HUMAN B2R6Q4_HUMAN 0.140780 U MK15_HUMAN GBRAP_HUMAN 0.543520 U MK15_HUMAN GBRL1_HUMAN 0.543520 U @@ -102318,7 +102245,6 @@ MK03_HUMAN STA5A_HUMAN 0.773333 D MK03_HUMAN C1QBP_HUMAN 0.169068 U MK03_HUMAN MK14_HUMAN 0.169068 U MK03_HUMAN RAB5A_HUMAN 0.553333 D -MK03_HUMAN MK03_HUMAN 0.553333 U MK03_HUMAN TNF11_HUMAN 0.169068 U MK03_HUMAN FGFR1_HUMAN 0.773333 D MK03_HUMAN RCAN1_HUMAN 0.140780 U @@ -105246,7 +105172,6 @@ ATM_HUMAN PP1A_HUMAN 0.401165 U ATM_HUMAN RIR1_HUMAN 0.401165 U ATM_HUMAN NBN_HUMAN 0.920000 D ATM_HUMAN SMAD1_HUMAN 0.773333 D -ATM_HUMAN ATM_HUMAN 0.976667 U ATM_HUMAN AP3B1_HUMAN 0.515545 U ATM_HUMAN E2F1_HUMAN 0.773333 D ATM_HUMAN AATF_HUMAN 0.553333 D @@ -107414,7 +107339,6 @@ TTK_HUMAN TBB5_HUMAN 0.414931 U TTK_HUMAN NTAN1_HUMAN 0.140780 U TTK_HUMAN MK06_HUMAN 0.405558 U TTK_HUMAN AAAS_HUMAN 0.140780 U -TTK_HUMAN TTK_HUMAN 0.996667 U TTK_HUMAN A4_HUMAN 0.438873 U TTK_HUMAN PGAM5_HUMAN 0.140780 U TTK_HUMAN NAGAB_HUMAN 0.140780 U @@ -108117,7 +108041,6 @@ NTRK1_HUMAN PTN6_HUMAN 0.401165 U NTRK1_HUMAN GRB2_HUMAN 0.615945 U NTRK1_HUMAN KDIS_HUMAN 0.205775 U NTRK1_HUMAN PTN22_HUMAN 0.438873 U -NTRK1_HUMAN NTRK1_HUMAN 0.886667 U NTRK1_HUMAN FRS3_HUMAN 0.292198 U NTRK1_HUMAN F8VPA5_HUMAN 0.140780 U NTRK1_HUMAN L7RTG7_HUMAN 0.541763 U @@ -109079,7 +109002,6 @@ AURKB_HUMAN NELFE_HUMAN 0.553333 D DAPK2_HUMAN TGFR1_HUMAN 0.357194 U DAPK2_HUMAN MLC1_HUMAN 0.140780 U DAPK2_HUMAN A4_HUMAN 0.438873 U -DAPK2_HUMAN DAPK2_HUMAN 0.553333 U DAPK2_HUMAN Q7LDD5_HUMAN 0.261094 U SELV_HUMAN PAXI1_HUMAN 0.527246 U ZN426_HUMAN FBLN4_HUMAN 0.580579 U @@ -109097,7 +109019,6 @@ PPCEL_HUMAN ACPH_HUMAN 0.345052 U PPCEL_HUMAN UBP22_HUMAN 0.401165 U PPCEL_HUMAN NR4A1_HUMAN 0.401165 U NUBPL_HUMAN PP1B_HUMAN 0.140780 U -STK16_HUMAN STK16_HUMAN 0.666667 U STK16_HUMAN CNTF_HUMAN 0.524233 U STK16_HUMAN KCD17_HUMAN 0.469622 U STK16_HUMAN RPIA_HUMAN 0.619429 U @@ -110017,7 +109938,6 @@ MERTK_HUMAN B0LPF3_HUMAN 0.447879 U MERTK_HUMAN NEMO_HUMAN 0.401165 U MERTK_HUMAN GAS6_HUMAN 0.539435 U MERTK_HUMAN VAV_HUMAN 0.282922 U -MERTK_HUMAN MERTK_HUMAN 0.886667 U MERTK_HUMAN ACK1_HUMAN 0.140780 U MERTK_HUMAN GRB2_HUMAN 0.140780 U TTI2_HUMAN EGFR_HUMAN 0.401165 U @@ -111503,7 +111423,6 @@ TNR18_HUMAN TRAF2_HUMAN 0.668590 U TNR18_HUMAN TRAF3_HUMAN 0.592242 U TNR18_HUMAN TRAF1_HUMAN 0.592242 U TNR18_HUMAN TNF18_HUMAN 0.718257 U -KCIP2_HUMAN KCIP2_HUMAN 0.438873 U KCIP2_HUMAN A4D0V9_HUMAN 0.936704 U KCIP2_HUMAN KCND3_HUMAN 0.140780 U KCIP2_HUMAN KCIP1_HUMAN 0.438873 U @@ -112018,7 +111937,6 @@ B1PKY1_HUMAN UBB_HUMAN 0.140780 U B1PKY1_HUMAN PDIA3_HUMAN 0.234063 U VGFR1_HUMAN NEDD4_HUMAN 0.558037 U VGFR1_HUMAN VEGFB_HUMAN 0.676128 U -VGFR1_HUMAN VGFR1_HUMAN 0.950000 U VGFR1_HUMAN VEGFA_HUMAN 0.438873 U VGFR1_HUMAN G3XA84_HUMAN 0.438873 U VGFR1_HUMAN VGFR2_HUMAN 0.438873 U @@ -112235,7 +112153,6 @@ GRP78_HUMAN KAPCB_HUMAN 0.401165 U GRP78_HUMAN SAHH2_HUMAN 0.345052 U GRP78_HUMAN A2MG_HUMAN 0.140780 U GRP78_HUMAN IST1_HUMAN 0.345052 U -GRP78_HUMAN GRP78_HUMAN 0.553333 U GRP78_HUMAN PDIA1_HUMAN 0.345052 U GRP78_HUMAN CAND1_HUMAN 0.401165 U GRP78_HUMAN Q6T424_HUMAN 0.438873 U @@ -113183,7 +113100,6 @@ P73_HUMAN JPH1_HUMAN 0.401165 U P73_HUMAN HMGB1_HUMAN 0.569273 U P73_HUMAN MDM2_HUMAN 0.946915 U P73_HUMAN IASPP_HUMAN 0.438873 U -P73_HUMAN P73_HUMAN 0.479927 U P73_HUMAN R144B_HUMAN 0.401165 U P73_HUMAN KAT2B_HUMAN 0.601642 U P73_HUMAN NEDD8_HUMAN 0.401165 U @@ -117239,7 +117155,6 @@ RAB18_HUMAN SUMO2_HUMAN 0.401165 U RAB18_HUMAN MYO5A_HUMAN 0.140780 U RAB18_HUMAN PDE6D_HUMAN 0.580579 U Q15300_HUMAN STAT3_HUMAN 0.663333 D -Q15300_HUMAN Q15300_HUMAN 0.553333 U ZXDC_HUMAN F1D8N1_HUMAN 0.405558 U ZXDC_HUMAN JTB_HUMAN 0.405558 U ZXDC_HUMAN C2TA_HUMAN 0.569914 U @@ -117943,7 +117858,6 @@ ACK1_HUMAN A4D1C5_HUMAN 0.438873 U ACK1_HUMAN PAK2_HUMAN 0.438873 U ACK1_HUMAN FYN_HUMAN 0.140780 U ACK1_HUMAN RGRF1_HUMAN 0.234063 U -ACK1_HUMAN ACK1_HUMAN 0.553333 U ACK1_HUMAN RGF1C_HUMAN 0.447879 U ACK1_HUMAN EGFR_HUMAN 0.280179 U ACK1_HUMAN CSPG4_HUMAN 0.261094 U @@ -117952,7 +117866,6 @@ ACK1_HUMAN F8VPA5_HUMAN 0.140780 U ACK1_HUMAN WWOX_HUMAN 0.663333 D ACK1_HUMAN GRB2_HUMAN 0.140780 U O2AG1_HUMAN MPDZ_HUMAN 0.611132 U -PK3CD_HUMAN PK3CD_HUMAN 0.553333 U PK3CD_HUMAN CD37_HUMAN 0.401165 U PK3CD_HUMAN SCF_HUMAN 0.140780 U PK3CD_HUMAN RASE_HUMAN 0.140780 U @@ -118127,7 +118040,6 @@ DAPK3_HUMAN MET_HUMAN 0.236421 U DAPK3_HUMAN RAD21_HUMAN 0.527246 U DAPK3_HUMAN PP14A_HUMAN 0.620000 D DAPK3_HUMAN DAXX_HUMAN 0.506360 U -DAPK3_HUMAN DAPK3_HUMAN 0.756667 U DAPK3_HUMAN KPCZ_HUMAN 0.450549 U DAPK3_HUMAN AATF_HUMAN 0.260150 U RWDD4_HUMAN BRCA1_HUMAN 0.405558 U @@ -121198,7 +121110,6 @@ KCC2A_HUMAN NCOR2_HUMAN 0.840000 D KCC2A_HUMAN TAU_HUMAN 0.620000 D KCC2A_HUMAN OPRM_HUMAN 0.663333 D KCC2A_HUMAN HRH1_HUMAN 0.700000 D -KCC2A_HUMAN KCC2A_HUMAN 0.886667 U KCC2A_HUMAN HSF1_HUMAN 0.553333 D KCC2A_HUMAN FLNA_HUMAN 0.663333 D KCC2A_HUMAN LGUL_HUMAN 0.663333 D @@ -121586,7 +121497,6 @@ AKT1_HUMAN GSK3A_HUMAN 0.553333 D GSK3A_HUMAN M3K11_HUMAN 0.524233 U GSK3A_HUMAN CREB1_HUMAN 0.438873 U GSK3A_HUMAN B2CL1_HUMAN 0.553333 D -GSK3A_HUMAN GSK3A_HUMAN 0.663333 U GSK3A_HUMAN SPG21_HUMAN 0.405558 U KS6A3_HUMAN GSK3A_HUMAN 0.553333 D GSK3A_HUMAN BICD1_HUMAN 0.140780 U @@ -122822,7 +122732,6 @@ DPEP3_HUMAN CHD4_HUMAN 0.401165 U CRUM3_HUMAN Q658X5_HUMAN 0.234063 U ZN829_HUMAN SMRCD_HUMAN 0.401165 U ZN829_HUMAN SUV91_HUMAN 0.401165 U -CDKL5_HUMAN CDKL5_HUMAN 0.620000 U CDKL5_HUMAN FYN_HUMAN 0.401165 U CDKL5_HUMAN MECP2_HUMAN 0.543520 U CDKL5_HUMAN B4DEE8_HUMAN 0.401165 U @@ -123412,7 +123321,6 @@ MP2K4_HUMAN GEMI5_HUMAN 0.468652 U MP2K4_HUMAN D4Q8H0_HUMAN 0.140780 U MP2K4_HUMAN TRIB1_HUMAN 0.414931 U MP2K4_HUMAN B0QZ35_HUMAN 0.438873 U -MP2K4_HUMAN MP2K4_HUMAN 0.620000 U MP2K4_HUMAN MK12_HUMAN 0.140780 U MP2K4_HUMAN MK10_HUMAN 0.730000 D MP2K4_HUMAN COM1_HUMAN 0.405558 U @@ -124461,7 +124369,6 @@ MK07_HUMAN G3P_HUMAN 0.401165 U MK07_HUMAN A4_HUMAN 0.438873 U MK07_HUMAN ETS1_HUMAN 0.773333 D MK07_HUMAN GOGB1_HUMAN 0.405558 U -MK07_HUMAN MK07_HUMAN 0.756667 U MK07_HUMAN BAG3_HUMAN 0.401165 U MK07_HUMAN ACTB_HUMAN 0.401165 U MK07_HUMAN D0PNI1_HUMAN 0.401165 U @@ -124893,7 +124800,6 @@ VGFR2_HUMAN RASA1_HUMAN 0.140780 U VGFR2_HUMAN MET_HUMAN 0.401165 U VGFR2_HUMAN SHB_HUMAN 0.592156 U VGFR2_HUMAN PLXA1_HUMAN 0.401165 U -VGFR2_HUMAN VGFR2_HUMAN 0.976667 U VGFR2_HUMAN PLCG2_HUMAN 0.234063 U VGFR2_HUMAN YES_HUMAN 0.140780 U VGFR2_HUMAN NPM_HUMAN 0.401165 U @@ -125473,7 +125379,6 @@ ABL2_HUMAN JAK1_HUMAN 0.401165 U ABL2_HUMAN RIN1_HUMAN 0.597629 U ABL2_HUMAN CRK_HUMAN 0.553333 D ABL2_HUMAN TPD53_HUMAN 0.405558 U -ABL2_HUMAN ABL2_HUMAN 0.620000 U ABL2_HUMAN CIP4_HUMAN 0.405558 U ABL2_HUMAN NEDD4_HUMAN 0.438873 U ABL2_HUMAN EGFR_HUMAN 0.526940 U @@ -128159,7 +128064,6 @@ FA58A_HUMAN C1QBP_HUMAN 0.140780 U FA58A_HUMAN PYR1_HUMAN 0.140780 U FA58A_HUMAN GSKIP_HUMAN 0.140780 U NEK9_HUMAN RAN_HUMAN 0.558249 U -NEK9_HUMAN NEK9_HUMAN 0.840000 U NEK9_HUMAN DYL1_HUMAN 0.401165 U NEK9_HUMAN B4DT73_HUMAN 0.401165 U NEK9_HUMAN SPDLY_HUMAN 0.401165 U @@ -128682,7 +128586,6 @@ GLO2_HUMAN THNS2_HUMAN 0.140780 U GLO2_HUMAN MYOC_HUMAN 0.405558 U GLO2_HUMAN BST2_HUMAN 0.507011 U GLO2_HUMAN TE2IP_HUMAN 0.405558 U -GRIK2_HUMAN GRIK2_HUMAN 0.292198 U GRIK2_HUMAN GRIA1_HUMAN 0.140780 U GRIK2_HUMAN CTNB1_HUMAN 0.169068 U GRIK2_HUMAN CACO1_HUMAN 0.367850 U @@ -129796,7 +129699,6 @@ CDA7L_HUMAN VDR_HUMAN 0.405558 U ALK_HUMAN MK01_HUMAN 0.401165 U ALK_HUMAN SMC6_HUMAN 0.401165 U ALK_HUMAN IRS4_HUMAN 0.401165 U -ALK_HUMAN ALK_HUMAN 0.553333 U ALK_HUMAN IF4B_HUMAN 0.401165 U ALK_HUMAN PTPRJ_HUMAN 0.438873 U ALK_HUMAN PLCG1_HUMAN 0.823094 U @@ -130065,7 +129967,6 @@ HNRPD_HUMAN HDAC5_HUMAN 0.401165 U HNRPD_HUMAN FUBP2_HUMAN 0.524233 U HNRPD_HUMAN UBC9_HUMAN 0.541763 U HNRPD_HUMAN CAND1_HUMAN 0.401165 U -HNRPD_HUMAN HNRPD_HUMAN 0.367850 U HNRPD_HUMAN HNRH3_HUMAN 0.405558 U HNRPD_HUMAN RBMX_HUMAN 0.345052 U HNRPD_HUMAN BCL2_HUMAN 0.405558 U @@ -130962,7 +130863,6 @@ DYR1A_HUMAN CREB1_HUMAN 0.292198 U DYR1A_HUMAN KIFA3_HUMAN 0.140780 U DYR1A_HUMAN SRSF4_HUMAN 0.438873 U DYR1A_HUMAN MERL_HUMAN 0.140780 U -DYR1A_HUMAN DYR1A_HUMAN 0.663333 U DYR1A_HUMAN EST1A_HUMAN 0.140780 U DYR1A_HUMAN AMPH_HUMAN 0.920000 D DYR1A_HUMAN PHYIP_HUMAN 0.351708 U @@ -131466,7 +131366,6 @@ PAK2_HUMAN CASP7_HUMAN 0.618780 U PAK2_HUMAN A4D2P1_HUMAN 0.841957 U PAK2_HUMAN RHG10_HUMAN 0.282922 U PAK2_HUMAN 1433S_HUMAN 0.401165 U -PAK2_HUMAN PAK2_HUMAN 0.553333 U PAK2_HUMAN PGRC1_HUMAN 0.401165 U PAK2_HUMAN ERP44_HUMAN 0.401165 U PAK2_HUMAN CASP3_HUMAN 0.234063 U @@ -131940,7 +131839,6 @@ M4K1_HUMAN DBNL_HUMAN 0.282922 U M4K1_HUMAN PLCG1_HUMAN 0.664050 U M4K1_HUMAN M3K11_HUMAN 0.553333 D M4K1_HUMAN LRRK1_HUMAN 0.401165 U -M4K1_HUMAN M4K1_HUMAN 0.553333 U KPCD1_HUMAN M4K1_HUMAN 0.553333 D M4K1_HUMAN FYN_HUMAN 0.401165 U M4K1_HUMAN LAT_HUMAN 0.498539 U @@ -132612,7 +132510,6 @@ STK38_HUMAN RICTR_HUMAN 0.401165 U STK38_HUMAN MOB2_HUMAN 0.621015 U STK38_HUMAN B4E1P5_HUMAN 0.401165 U STK38_HUMAN KMT2E_HUMAN 0.401165 U -STK38_HUMAN STK38_HUMAN 0.840000 U STK38_HUMAN CTDP1_HUMAN 0.589101 U STK38_HUMAN MYSM1_HUMAN 0.401165 U STK38_HUMAN D0PNI1_HUMAN 0.524233 U @@ -133112,7 +133009,6 @@ KS6A4_HUMAN MK01_HUMAN 0.169068 U KS6A4_HUMAN CREB1_HUMAN 0.663333 D MK14_HUMAN KS6A4_HUMAN 0.663333 D KS6A4_HUMAN ATF1_HUMAN 0.140780 U -KS6A4_HUMAN KS6A4_HUMAN 0.663333 U KS6A4_HUMAN A4QPA9_HUMAN 0.169068 U FHR5_HUMAN CO3_HUMAN 0.526940 U Q68DI0_HUMAN CXCR2_HUMAN 0.140780 U @@ -133186,7 +133082,6 @@ VINC_HUMAN SNRPA_HUMAN 0.378760 U VINC_HUMAN E9KL35_HUMAN 0.378760 U VINC_HUMAN MOT6_HUMAN 0.378760 U VINC_HUMAN RS21_HUMAN 0.378760 U -VINC_HUMAN VINC_HUMAN 0.292198 U VINC_HUMAN PDIA3_HUMAN 0.378760 U VINC_HUMAN MRP6_HUMAN 0.140780 U VINC_HUMAN BIRC6_HUMAN 0.447879 U @@ -133458,7 +133353,6 @@ SRPK2_HUMAN PPIL1_HUMAN 0.438873 U SRPK2_HUMAN HOME3_HUMAN 0.438873 U SRPK2_HUMAN ACINU_HUMAN 0.773333 D A0N0L8_HUMAN Q53QY6_HUMAN 0.561660 U -ENPP3_HUMAN ENPP3_HUMAN 0.553333 U PSMD6_HUMAN 1C04_HUMAN 0.401165 U PSMD6_HUMAN A8K2M0_HUMAN 0.479927 U PSMD6_HUMAN RS3A_HUMAN 0.401165 U @@ -134109,7 +134003,6 @@ FYN_HUMAN DOK4_HUMAN 0.347780 U FYN_HUMAN SP1_HUMAN 0.401165 U FYN_HUMAN RP1L1_HUMAN 0.401165 U FYN_HUMAN FYB_HUMAN 0.776667 D -FYN_HUMAN FYN_HUMAN 0.920000 U PGFRB_HUMAN FYN_HUMAN 0.553333 D FYN_HUMAN HXC8_HUMAN 0.401165 U FYN_HUMAN SUV92_HUMAN 0.401165 U @@ -135819,7 +135712,6 @@ MERL_HUMAN EZRI_HUMAN 0.676128 U MERL_HUMAN D2CFK9_HUMAN 0.610394 U M3K11_HUMAN CBL_HUMAN 0.401165 U AKT1_HUMAN M3K11_HUMAN 0.773333 D -M3K11_HUMAN M3K11_HUMAN 0.620000 U M3K11_HUMAN SH3R1_HUMAN 0.596842 U M3K11_HUMAN A4QPA9_HUMAN 0.261094 U M3K11_HUMAN IKKB_HUMAN 0.623245 U @@ -137622,7 +137514,6 @@ TEC_HUMAN PTPRJ_HUMAN 0.438873 U TEC_HUMAN P55G_HUMAN 0.325146 U TEC_HUMAN PLCG1_HUMAN 0.140780 U TEC_HUMAN WASP_HUMAN 0.538067 U -TEC_HUMAN TEC_HUMAN 0.553333 U TEC_HUMAN PTPRK_HUMAN 0.438873 U TEC_HUMAN VAV_HUMAN 0.552475 U TEC_HUMAN JAK1_HUMAN 0.506360 U @@ -138867,7 +138758,6 @@ PAK4_HUMAN LIMK1_HUMAN 0.558037 U PAK4_HUMAN LRRK1_HUMAN 0.401165 U PAK4_HUMAN A4_HUMAN 0.438873 U PAK4_HUMAN 1433T_HUMAN 0.589229 U -PAK4_HUMAN PAK4_HUMAN 0.773333 U PAK4_HUMAN D0PNI1_HUMAN 0.701756 U PAK4_HUMAN L7RT22_HUMAN 0.601642 U PAK4_HUMAN ITAV_HUMAN 0.140780 U @@ -140457,7 +140347,6 @@ MK06_HUMAN ACTG_HUMAN 0.507011 U MK06_HUMAN HAUS2_HUMAN 0.507011 U MK06_HUMAN I3WAC9_HUMAN 0.507011 U MK06_HUMAN NDUS6_HUMAN 0.507011 U -MK06_HUMAN MK06_HUMAN 0.553333 U MK06_HUMAN MK_HUMAN 0.507011 U MK06_HUMAN F8W6L3_HUMAN 0.405558 U MK06_HUMAN B7Z339_HUMAN 0.405558 U @@ -142273,7 +142162,6 @@ LCK_HUMAN L7RRS6_HUMAN 0.506360 U LCK_HUMAN LAT_HUMAN 0.729184 U LCK_HUMAN DOK3_HUMAN 0.140780 U LCK_HUMAN GAB2_HUMAN 0.140780 U -LCK_HUMAN LCK_HUMAN 0.840000 U LCK_HUMAN SOCS3_HUMAN 0.620000 D LCK_HUMAN B0YJA4_HUMAN 0.552475 U LCK_HUMAN SH21A_HUMAN 0.367850 U @@ -142506,7 +142394,6 @@ BTK_HUMAN CBL_HUMAN 0.809910 U BTK_HUMAN COR1C_HUMAN 0.401165 U BTK_HUMAN JAK1_HUMAN 0.506360 U BTK_HUMAN A4_HUMAN 0.438873 U -BTK_HUMAN BTK_HUMAN 0.840000 U BTK_HUMAN 3BP5_HUMAN 0.524233 U BTK_HUMAN PI42C_HUMAN 0.234063 U BTK_HUMAN KPCT_HUMAN 0.540871 U @@ -142904,7 +142791,6 @@ PML_HUMAN NCOR2_HUMAN 0.140780 U PML_HUMAN AIMP2_HUMAN 0.267760 U PML_HUMAN TNR6_HUMAN 0.524233 U PML_HUMAN K7ENL3_HUMAN 0.140780 U -PML_HUMAN PML_HUMAN 0.367850 U PML_HUMAN NR4A1_HUMAN 0.169068 U PML_HUMAN RN111_HUMAN 0.367850 U PML_HUMAN PIN1_HUMAN 0.543520 U @@ -143360,7 +143246,6 @@ B2CL1_HUMAN BAD_HUMAN 0.968410 U B2CL1_HUMAN HRK_HUMAN 0.921346 U B2CL1_HUMAN ZFYV1_HUMAN 0.367850 U LATS1_HUMAN MOB3B_HUMAN 0.438873 U -LATS1_HUMAN LATS1_HUMAN 0.620000 U NUAK2_HUMAN LATS1_HUMAN 0.553333 D LATS1_HUMAN LIMK1_HUMAN 0.720369 U CDK1_HUMAN LATS1_HUMAN 0.840000 D @@ -144826,7 +144711,6 @@ PGFRB_HUMAN YES_HUMAN 0.378731 U PGFRB_HUMAN SHB_HUMAN 0.451437 U PGFRB_HUMAN FAK1_HUMAN 0.840000 D PGFRB_HUMAN JAK1_HUMAN 0.234063 U -PGFRB_HUMAN PGFRB_HUMAN 0.996667 U PGFRB_HUMAN B7Z4L6_HUMAN 0.401165 U PGFRB_HUMAN SNX4_HUMAN 0.414931 U PGFRB_HUMAN ARAF_HUMAN 0.169068 U @@ -144976,7 +144860,6 @@ MAPK2_HUMAN CREB1_HUMAN 0.773333 D MAPK2_HUMAN MPIP3_HUMAN 0.553333 D MAPK2_HUMAN LIMK1_HUMAN 0.773333 D MAPK2_HUMAN TSC2_HUMAN 0.773333 D -MAPK2_HUMAN MAPK2_HUMAN 0.663333 U MAPK2_HUMAN AKT2_HUMAN 0.438873 U MAPK2_HUMAN HSF1_HUMAN 0.553333 D MAPK2_HUMAN CPZIP_HUMAN 0.620000 D @@ -145482,7 +145365,6 @@ EGFR_HUMAN CASP7_HUMAN 0.438873 U EGFR_HUMAN BIRC3_HUMAN 0.401165 U EGFR_HUMAN TPIS_HUMAN 0.367850 U EGFR_HUMAN K7ENL3_HUMAN 0.140780 U -EGFR_HUMAN EGFR_HUMAN 0.976667 U EGFR_HUMAN HGS_HUMAN 0.906983 U EGFR_HUMAN SEC13_HUMAN 0.401165 U EGFR_HUMAN S39AB_HUMAN 0.401165 U @@ -145753,7 +145635,6 @@ ISCU_HUMAN KYNU_HUMAN 0.140780 U ISCU_HUMAN KPYM_HUMAN 0.140780 U ISCU_HUMAN NFU1_HUMAN 0.140780 U ISCU_HUMAN 1433S_HUMAN 0.401165 U -PLK4_HUMAN PLK4_HUMAN 0.920000 U PLK4_HUMAN ECT2_HUMAN 0.618476 U PLK4_HUMAN 1433S_HUMAN 0.695111 U RBMX_HUMAN STA5A_HUMAN 0.507011 U @@ -147588,7 +147469,6 @@ MLTK_HUMAN RN19A_HUMAN 0.507011 U MLTK_HUMAN VP33B_HUMAN 0.507011 U MLTK_HUMAN 1433S_HUMAN 0.524233 U MLTK_HUMAN H31_HUMAN 0.773333 D -MLTK_HUMAN MLTK_HUMAN 0.886667 U MLTK_HUMAN PKN1_HUMAN 0.401165 U MLTK_HUMAN U119A_HUMAN 0.507011 U MLTK_HUMAN Q6PD56_HUMAN 0.405558 U @@ -147658,7 +147538,6 @@ TF2AY_HUMAN MAFF_HUMAN 0.405558 U TF2AY_HUMAN MAFG_HUMAN 0.405558 U M3K4_HUMAN PTN6_HUMAN 0.395172 U M3K4_HUMAN ANXA2_HUMAN 0.401165 U -M3K4_HUMAN M3K4_HUMAN 0.663333 U M3K4_HUMAN E9KL35_HUMAN 0.401165 U M3K4_HUMAN TPR_HUMAN 0.367850 U KCNN2_HUMAN B4DJ51_HUMAN 0.628584 U @@ -147906,7 +147785,6 @@ ITB6_HUMAN Q60FE5_HUMAN 0.405558 U RIR2B_HUMAN NBN_HUMAN 0.401165 U TRPM7_HUMAN MYH9_HUMAN 0.666667 D TRPM7_HUMAN TRPM6_HUMAN 0.378731 U -TRPM7_HUMAN TRPM7_HUMAN 0.776667 U KCC2B_HUMAN AAPK1_HUMAN 0.553333 D KCC2B_HUMAN ETS1_HUMAN 0.140780 U PACN3_HUMAN FKBP3_HUMAN 0.345052 U @@ -148024,7 +147902,6 @@ CDK1_HUMAN MPIP3_HUMAN 0.976667 D BRSK1_HUMAN MPIP3_HUMAN 0.773333 D ZN835_HUMAN TULP3_HUMAN 0.367850 U PCSK1_HUMAN NEC1_HUMAN 0.140780 U -NEK2_HUMAN NEK2_HUMAN 0.776667 U NEK2_HUMAN IMMT_HUMAN 0.367850 U NEK2_HUMAN TCF25_HUMAN 0.367850 U NEK2_HUMAN APC4_HUMAN 0.401165 U @@ -148614,7 +148491,6 @@ KS6A5_HUMAN U119A_HUMAN 0.405558 U KS6A5_HUMAN Q6PD56_HUMAN 0.405558 U KS6A5_HUMAN TY3H_HUMAN 0.553333 D KS6A5_HUMAN ACTG_HUMAN 0.405558 U -KS6A5_HUMAN KS6A5_HUMAN 0.976667 U FIP1_HUMAN WWOX_HUMAN 0.493320 U FIP1_HUMAN ANM2_HUMAN 0.367850 U FIP1_HUMAN CPSF4_HUMAN 0.447879 U @@ -149375,7 +149251,6 @@ HSF1_HUMAN HDAC2_HUMAN 0.589229 U HSF1_HUMAN NCOA6_HUMAN 0.506319 U HSF1_HUMAN AAMP_HUMAN 0.401165 U MP2K6_HUMAN MK12_HUMAN 0.620000 D -MP2K6_HUMAN MP2K6_HUMAN 0.730000 U ANXA6_HUMAN H6UYS5_HUMAN 0.309917 U ANXA6_HUMAN CUL5_HUMAN 0.401165 U ANXA6_HUMAN S10A1_HUMAN 0.438873 U @@ -149726,9 +149601,7 @@ CASP1_HUMAN IL37_HUMAN 0.438873 U CASP1_HUMAN BIRC3_HUMAN 0.401165 U CASP1_HUMAN CASPA_HUMAN 0.438873 U CASP1_HUMAN IL33_HUMAN 0.438873 U -CASP1_HUMAN CASP1_HUMAN 0.451437 U E7EPS7_HUMAN PAXI1_HUMAN 0.405558 U -NTRK2_HUMAN NTRK2_HUMAN 0.553333 U NTRK2_HUMAN F5GXU7_HUMAN 0.405558 U NTRK2_HUMAN A8K3M3_HUMAN 0.309917 U NTRK2_HUMAN DOK5_HUMAN 0.260150 U @@ -149999,7 +149872,6 @@ PSB2_HUMAN GPX2_HUMAN 0.367850 U CLD19_HUMAN CLD16_HUMAN 0.401165 U KKCC1_HUMAN BRSK1_HUMAN 0.553333 D STK11_HUMAN BRSK1_HUMAN 0.620000 D -BRSK1_HUMAN BRSK1_HUMAN 0.620000 U BRSK1_HUMAN AAPK1_HUMAN 0.553333 D PSF2_HUMAN MVD1_HUMAN 0.401165 U PSF2_HUMAN GSHR_HUMAN 0.401165 U @@ -150607,7 +150479,6 @@ FGFR4_HUMAN FGF5_HUMAN 0.140780 U FGFR4_HUMAN EPHA4_HUMAN 0.140780 U FGFR4_HUMAN A8K147_HUMAN 0.623033 U FGFR4_HUMAN CDK9_HUMAN 0.401165 U -FGFR4_HUMAN FGFR4_HUMAN 0.553333 U FGFR4_HUMAN FGF4_HUMAN 0.140780 U FGFR4_HUMAN FGF7_HUMAN 0.140780 U FGFR4_HUMAN STAT1_HUMAN 0.391290 U @@ -150722,7 +150593,6 @@ FGFR1_HUMAN FGF7_HUMAN 0.140780 U FGFR1_HUMAN KALM_HUMAN 0.581992 U FGFR1_HUMAN SHB_HUMAN 0.543520 U FGFR1_HUMAN FGF1_HUMAN 0.908213 U -FGFR1_HUMAN FGFR1_HUMAN 0.776667 U FGFR1_HUMAN NEDD4_HUMAN 0.676128 U FGFR1_HUMAN FGF18_HUMAN 0.140780 U FGFR1_HUMAN FGF4_HUMAN 0.140780 U @@ -150882,7 +150752,6 @@ PEX5_HUMAN GBRAP_HUMAN 0.140780 U PEX5_HUMAN KPCI_HUMAN 0.140780 U PEX5_HUMAN PEX7_HUMAN 0.347918 U DAPK1_HUMAN B4DJ51_HUMAN 0.696754 U -DAPK1_HUMAN DAPK1_HUMAN 0.773333 U DAPK1_HUMAN CUL3_HUMAN 0.524233 U DAPK1_HUMAN KPYM_HUMAN 0.632805 U DAPK1_HUMAN LRRK1_HUMAN 0.524233 U @@ -151336,7 +151205,6 @@ KPYM_HUMAN ARRB1_HUMAN 0.401165 U KPYM_HUMAN PIN1_HUMAN 0.447879 U KPYM_HUMAN NDRG1_HUMAN 0.401165 U T2FA_HUMAN RPB11_HUMAN 0.589229 U -T2FA_HUMAN T2FA_HUMAN 0.620000 U T2FA_HUMAN MEPCE_HUMAN 0.401165 U T2FA_HUMAN CDK8_HUMAN 0.401165 U T2FA_HUMAN RPB4_HUMAN 0.345052 U @@ -152099,7 +151967,6 @@ PSMD7_HUMAN NFKB2_HUMAN 0.140780 U PSMD7_HUMAN PSD10_HUMAN 0.479927 U PSMD7_HUMAN ATX3_HUMAN 0.498539 U PSMD7_HUMAN THTR_HUMAN 0.345052 U -TXK_HUMAN TXK_HUMAN 0.620000 U Q15559_HUMAN WBP4_HUMAN 0.401165 U A26L1_HUMAN TRAF2_HUMAN 0.447879 U CBPM_HUMAN D1MGQ2_HUMAN 0.140780 U @@ -152835,7 +152702,6 @@ KPCD1_HUMAN MK09_HUMAN 0.401165 U KPCD1_HUMAN MARK2_HUMAN 0.663333 D KPCD1_HUMAN TLR4_HUMAN 0.553333 D KPCD1_HUMAN 1433T_HUMAN 0.685822 U -KPCD1_HUMAN KPCD1_HUMAN 0.840000 U KPCD1_HUMAN E9KL35_HUMAN 0.313764 U KPCD1_HUMAN TLR5_HUMAN 0.773333 D ABL1_HUMAN KPCD1_HUMAN 0.773333 D @@ -152992,7 +152858,6 @@ CSF1R_HUMAN CBL_HUMAN 0.918502 U CSF1R_HUMAN CSF1_HUMAN 0.899577 U CSF1R_HUMAN B7ZLX0_HUMAN 0.401165 U CSF1R_HUMAN YES_HUMAN 0.506360 U -CSF1R_HUMAN CSF1R_HUMAN 0.920000 U CSF1R_HUMAN SOCS3_HUMAN 0.506360 U CSF1R_HUMAN RASA1_HUMAN 0.261094 U CSF1R_HUMAN IL34_HUMAN 0.785698 U @@ -153051,7 +152916,6 @@ GRK5_HUMAN NCBP1_HUMAN 0.401165 U GRK5_HUMAN A4D1Q0_HUMAN 0.234063 U GRK5_HUMAN GIT1_HUMAN 0.234063 U GRK5_HUMAN FMNL2_HUMAN 0.401165 U -GRK5_HUMAN GRK5_HUMAN 0.620000 U GRK5_HUMAN BKRB2_HUMAN 0.169068 U GRK5_HUMAN NOLC1_HUMAN 0.401165 U GRK5_HUMAN CAV1_HUMAN 0.140780 U @@ -153776,7 +153640,6 @@ STK3_HUMAN A8K015_HUMAN 0.507011 U STK3_HUMAN Q6FHY4_HUMAN 0.140780 U STK3_HUMAN SPTN4_HUMAN 0.401165 U STK3_HUMAN F5H282_HUMAN 0.401165 U -STK3_HUMAN STK3_HUMAN 0.663333 U STK3_HUMAN GBRAP_HUMAN 0.543520 U STK3_HUMAN SRP14_HUMAN 0.401165 U STK3_HUMAN YAP1_HUMAN 0.663333 D @@ -154650,7 +154513,6 @@ GHR_HUMAN PTPRB_HUMAN 0.683472 U STK11_HUMAN MARK3_HUMAN 0.840000 D STK11_HUMAN KS6A3_HUMAN 0.234063 U STK11_HUMAN NUAK1_HUMAN 0.773333 D -STK11_HUMAN STK11_HUMAN 0.756667 U STK11_HUMAN SIK2_HUMAN 0.773333 D STK11_HUMAN WDR6_HUMAN 0.542597 U STK11_HUMAN MARK2_HUMAN 0.773333 D @@ -154781,7 +154643,6 @@ KPCD_HUMAN DAB2_HUMAN 0.553333 D KPCD_HUMAN RS3_HUMAN 0.840000 D KPCD_HUMAN STAT1_HUMAN 0.663333 D KPCD_HUMAN TBB4B_HUMAN 0.401165 U -KPCD_HUMAN KPCD_HUMAN 0.996667 U KPCD_HUMAN HABP4_HUMAN 0.438873 U KPCD_HUMAN RS11_HUMAN 0.401165 U KPCD_HUMAN MST4_HUMAN 0.401165 U @@ -154845,7 +154706,6 @@ UCHL1_HUMAN UBC9_HUMAN 0.547059 U UCHL1_HUMAN TE2IP_HUMAN 0.405558 U ST38L_HUMAN K1H1_HUMAN 0.524233 U ST38L_HUMAN NUAK1_HUMAN 0.663333 D -ST38L_HUMAN ST38L_HUMAN 0.663333 U ST38L_HUMAN MOB2_HUMAN 0.621015 U ST38L_HUMAN ARRB1_HUMAN 0.401165 U D4HNR6_HUMAN IRF2_HUMAN 0.524233 U @@ -155050,10 +154910,8 @@ A8YXX4_HUMAN KDSR_HUMAN 0.140780 U A8YXX4_HUMAN HIPK3_HUMAN 0.367850 U A8YXX4_HUMAN UBC9_HUMAN 0.507011 U A8YXX4_HUMAN CP39A_HUMAN 0.507011 U -ULK3_HUMAN ULK3_HUMAN 0.700000 U MARF1_HUMAN KIF4A_HUMAN 0.140780 U MARF1_HUMAN MSI2H_HUMAN 0.140780 U -5HT4R_HUMAN 5HT4R_HUMAN 0.401165 U RLA0L_HUMAN M3K1_HUMAN 0.493320 U RLA0L_HUMAN RELB_HUMAN 0.493320 U RLA0L_HUMAN M3K7_HUMAN 0.401165 U @@ -155461,7 +155319,6 @@ AIFM1_HUMAN NFKB2_HUMAN 0.479927 U AIFM1_HUMAN CDK2_HUMAN 0.401165 U AIFM1_HUMAN MST4_HUMAN 0.401165 U AIFM1_HUMAN HEM6_HUMAN 0.345052 U -AIFM1_HUMAN AIFM1_HUMAN 0.401165 U AIFM1_HUMAN CUL3_HUMAN 0.401165 U AIFM1_HUMAN T22D4_HUMAN 0.625748 U AIFM1_HUMAN M3K1_HUMAN 0.479927 U @@ -155510,7 +155367,6 @@ PK3CG_HUMAN RASK_HUMAN 0.550949 U PK3CG_HUMAN UTRO_HUMAN 0.401165 U PK3CG_HUMAN CD37_HUMAN 0.401165 U PK3CG_HUMAN UBP45_HUMAN 0.401165 U -PK3CG_HUMAN PK3CG_HUMAN 0.553333 U PK3CG_HUMAN ARBK1_HUMAN 0.357194 U MFSD3_HUMAN APBP2_HUMAN 0.619429 U LSM7_HUMAN RFX5_HUMAN 0.345052 U @@ -155798,7 +155654,6 @@ PRKRA_HUMAN RL36_HUMAN 0.401165 U KCC2G_HUMAN STAT1_HUMAN 0.234063 U KCC2G_HUMAN B4DJ51_HUMAN 0.515545 U KCC2G_HUMAN PDE4A_HUMAN 0.140780 U -KCC2G_HUMAN KCC2G_HUMAN 0.620000 U Q9BU08_HUMAN DDX47_HUMAN 0.140780 U Q9BU08_HUMAN ARPC4_HUMAN 0.140780 U Q9BU08_HUMAN NMD3_HUMAN 0.140780 U @@ -156302,7 +156157,6 @@ AAPK1_HUMAN GBF1_HUMAN 0.773333 D AAPK1_HUMAN PYC_HUMAN 0.401165 U AAPK1_HUMAN AAPK2_HUMAN 0.401165 U AAPK1_HUMAN RS11_HUMAN 0.401165 U -AAPK1_HUMAN AAPK1_HUMAN 0.756667 U AAPK1_HUMAN PRKDC_HUMAN 0.401165 U AAPK1_HUMAN IMA1_HUMAN 0.773333 D AAPK1_HUMAN TBB4A_HUMAN 0.401165 U @@ -156664,7 +156518,6 @@ PSRC1_HUMAN PTMA_HUMAN 0.345052 U RIC1_HUMAN CKS2_HUMAN 0.140780 U LEPR_HUMAN SNX4_HUMAN 0.401165 U LEPR_HUMAN B4DJS7_HUMAN 0.401165 U -LEPR_HUMAN LEPR_HUMAN 0.524233 U LEPR_HUMAN K7ENL3_HUMAN 0.140780 U LEPR_HUMAN DGKZ_HUMAN 0.234063 U LEPR_HUMAN JAK3_HUMAN 0.401165 U @@ -156789,7 +156642,6 @@ M3K7_HUMAN K9JA46_HUMAN 0.493320 U M3K7_HUMAN ZN746_HUMAN 0.367850 U M3K7_HUMAN RN19A_HUMAN 0.405558 U M3K7_HUMAN KAT2A_HUMAN 0.401165 U -M3K7_HUMAN M3K7_HUMAN 0.920000 U M3K7_HUMAN BBS10_HUMAN 0.405558 U M3K7_HUMAN IRAK1_HUMAN 0.778398 U M3K7_HUMAN PPM1L_HUMAN 0.558249 U @@ -156977,7 +156829,6 @@ IRAK1_HUMAN PIN1_HUMAN 0.645066 U IRAK1_HUMAN TNAP3_HUMAN 0.401165 U IRAK1_HUMAN STING_HUMAN 0.543520 U IRAK1_HUMAN KKCC2_HUMAN 0.401165 U -IRAK1_HUMAN IRAK1_HUMAN 0.620000 U AKT1_HUMAN IRAK1_HUMAN 0.553333 D IRAK1_HUMAN K7ENL3_HUMAN 0.140780 U IRAK1_HUMAN CUL3_HUMAN 0.401165 U @@ -157166,7 +157017,6 @@ IRF8_HUMAN SMUF2_HUMAN 0.292198 U IRF8_HUMAN HXC8_HUMAN 0.401165 U IRF8_HUMAN GNA13_HUMAN 0.401165 U NAIF1_HUMAN TE2IP_HUMAN 0.405558 U -EPHB3_HUMAN EPHB3_HUMAN 0.663333 U EPHB3_HUMAN LNX1_HUMAN 0.438873 U EPHB3_HUMAN RASA1_HUMAN 0.506319 U DAG1_HUMAN LAMA2_HUMAN 0.234063 U @@ -157206,7 +157056,6 @@ FAK1_HUMAN SOCS2_HUMAN 0.325146 U FAK1_HUMAN IGHM_HUMAN 0.169068 U FAK1_HUMAN GIT1_HUMAN 0.169068 U FAK1_HUMAN L7RT22_HUMAN 0.345052 U -FAK1_HUMAN FAK1_HUMAN 0.920000 U MET_HUMAN FAK1_HUMAN 0.996667 D FAK1_HUMAN EZRI_HUMAN 0.169068 U FAK1_HUMAN CSPG4_HUMAN 0.169068 U @@ -157343,7 +157192,6 @@ FRMD6_HUMAN T22D4_HUMAN 0.447879 U AR13A_HUMAN UBC9_HUMAN 0.401165 U AR13A_HUMAN SUMO2_HUMAN 0.438873 U SEC20_HUMAN NCBP1_HUMAN 0.405558 U -EPHA4_HUMAN EPHA4_HUMAN 0.620000 U EPHA4_HUMAN EFNA3_HUMAN 0.357912 U RAB1B_HUMAN RINI_HUMAN 0.401165 U CISD2_HUMAN LMNA_HUMAN 0.401165 U @@ -157444,7 +157292,6 @@ NUP98_HUMAN ECT2_HUMAN 0.401165 U NUP98_HUMAN LMNA_HUMAN 0.401165 U NUP98_HUMAN TRAF2_HUMAN 0.140780 U CDK1_HUMAN NUP98_HUMAN 0.730000 D -NUP98_HUMAN NUP98_HUMAN 0.292198 U NUP98_HUMAN TPR_HUMAN 0.662061 U UB2G1_HUMAN CBL_HUMAN 0.234063 U UB2G1_HUMAN SMUF2_HUMAN 0.269735 U @@ -157467,7 +157314,6 @@ LKHA4_HUMAN TMM62_HUMAN 0.547059 U MRCKA_HUMAN RAN_HUMAN 0.140780 U MRCKA_HUMAN LIMK1_HUMAN 0.280179 U MRCKA_HUMAN ML12A_HUMAN 0.438873 U -MRCKA_HUMAN MRCKA_HUMAN 0.666667 U MRCKA_HUMAN TAF1_HUMAN 0.367850 U CXA4_HUMAN OPRM_HUMAN 0.507959 U B2RTR1_HUMAN MARK2_HUMAN 0.401165 U @@ -158336,7 +158182,6 @@ ABL1_HUMAN 1433S_HUMAN 0.401165 U ABL1_HUMAN 1433T_HUMAN 0.140780 U ABL1_HUMAN SPR2A_HUMAN 0.438873 U ABL1_HUMAN APOL5_HUMAN 0.401165 U -ABL1_HUMAN ABL1_HUMAN 0.773333 U ABL1_HUMAN CKAP5_HUMAN 0.401165 U ABL1_HUMAN NCOA3_HUMAN 0.773333 D ABL1_HUMAN DYN2_HUMAN 0.401165 U @@ -158701,7 +158546,6 @@ JAK3_HUMAN TIAF1_HUMAN 0.646164 U JAK3_HUMAN STAT1_HUMAN 0.553333 D JAK3_HUMAN K7ENL3_HUMAN 0.140780 U JAK3_HUMAN JAK1_HUMAN 0.620000 D -JAK3_HUMAN JAK3_HUMAN 0.950000 U JAK3_HUMAN STAM1_HUMAN 0.565180 U JAK3_HUMAN PTN6_HUMAN 0.140780 U JAK3_HUMAN IL2RB_HUMAN 0.617471 U @@ -159021,7 +158865,6 @@ MYL4_HUMAN ITA4_HUMAN 0.401165 U HN1L_HUMAN LMNA_HUMAN 0.401165 U CDK2_HUMAN HN1L_HUMAN 0.553333 D MK12_HUMAN DLG2_HUMAN 0.140780 U -MK12_HUMAN MK12_HUMAN 0.553333 U MK12_HUMAN PKN1_HUMAN 0.428324 U ARGL1_HUMAN CDK2_HUMAN 0.401165 U APAF_HUMAN NALP1_HUMAN 0.498539 U @@ -159290,7 +159133,6 @@ KPCT_HUMAN MARK3_HUMAN 0.539435 U KPCT_HUMAN HABP4_HUMAN 0.620000 D KPCT_HUMAN EZRI_HUMAN 0.553333 D M4K3_HUMAN KPCT_HUMAN 0.773333 D -KPCT_HUMAN KPCT_HUMAN 0.663333 U KPCT_HUMAN H31_HUMAN 0.553333 D B5B2P4_HUMAN MK09_HUMAN 0.401165 U B5B2P4_HUMAN TFAP4_HUMAN 0.401165 U @@ -159484,7 +159326,6 @@ RAN_HUMAN ODP2_HUMAN 0.140780 U RAN_HUMAN TFAP4_HUMAN 0.401165 U RAN_HUMAN NFL_HUMAN 0.367850 U ZN439_HUMAN KR412_HUMAN 0.547059 U -PAXI_HUMAN PAXI_HUMAN 0.292198 U PAXI_HUMAN ASAP1_HUMAN 0.401165 U PAXI_HUMAN LEG1_HUMAN 0.378760 U PAXI_HUMAN G3BP1_HUMAN 0.378760 U @@ -159552,7 +159393,6 @@ STT3B_HUMAN UN93B_HUMAN 0.401165 U STT3B_HUMAN SEH1_HUMAN 0.140780 U STT3B_HUMAN EIF3I_HUMAN 0.140780 U AURKB_HUMAN RBM14_HUMAN 0.553333 D -AURKB_HUMAN AURKB_HUMAN 0.886667 U AURKB_HUMAN GFAP_HUMAN 0.886667 D AURKB_HUMAN SUMO2_HUMAN 0.667063 U AURKB_HUMAN CUL3_HUMAN 0.401165 U @@ -160039,7 +159879,6 @@ LIMS1_HUMAN PLRG1_HUMAN 0.140780 U LIMS1_HUMAN LONF3_HUMAN 0.140780 U LIMS1_HUMAN TITIN_HUMAN 0.367850 U LIMS1_HUMAN RSU1_HUMAN 0.447879 U -PK3CB_HUMAN PK3CB_HUMAN 0.553333 U PK3CB_HUMAN NBN_HUMAN 0.401165 U Q9BZY1_HUMAN 1433S_HUMAN 0.140780 U TAF8_HUMAN TAF1_HUMAN 0.401165 U @@ -160393,7 +160232,6 @@ PKP4_HUMAN PAXI1_HUMAN 0.405558 U KIFC1_HUMAN SUMO2_HUMAN 0.401165 U BIRC5_HUMAN USF2_HUMAN 0.401165 U BIRC5_HUMAN CDK2_HUMAN 0.401165 U -BIRC5_HUMAN BIRC5_HUMAN 0.543520 U BIRC5_HUMAN BIRC3_HUMAN 0.438873 U BIRC5_HUMAN PRKDC_HUMAN 0.401165 U IL3RB_HUMAN STAT1_HUMAN 0.140780 U @@ -160409,7 +160247,6 @@ A2I2P5_HUMAN NCOA3_HUMAN 0.450549 U EFHD2_HUMAN Q14D22_HUMAN 0.401165 U EFHD2_HUMAN FCL_HUMAN 0.401165 U CDK2_HUMAN EFHD2_HUMAN 0.620000 D -MET_HUMAN MET_HUMAN 0.920000 U MET_HUMAN K7ENL3_HUMAN 0.140780 U MET_HUMAN PLXB3_HUMAN 0.524233 U MET_HUMAN PTPRB_HUMAN 0.450549 U @@ -160422,7 +160259,6 @@ SURF4_HUMAN STING_HUMAN 0.602067 U SURF4_HUMAN SAFB1_HUMAN 0.345052 U SURF4_HUMAN UN93B_HUMAN 0.543520 U SURF4_HUMAN DEGS1_HUMAN 0.524233 U -TRPM6_HUMAN TRPM6_HUMAN 0.553333 U GLYG2_HUMAN GYS1_HUMAN 0.508594 U KS6A3_HUMAN RRN3_HUMAN 0.663333 D KS6A3_HUMAN H31_HUMAN 0.663333 D @@ -160546,7 +160382,6 @@ CDK9_HUMAN PRKDC_HUMAN 0.401165 U CDK9_HUMAN SHRM3_HUMAN 0.401165 U CDK9_HUMAN RS3A_HUMAN 0.401165 U CDK9_HUMAN HEXI1_HUMAN 0.973875 U -CDK9_HUMAN CDK9_HUMAN 0.756667 U CDK9_HUMAN RS3_HUMAN 0.401165 U CDK9_HUMAN TBB4B_HUMAN 0.589229 U CDK9_HUMAN PYC_HUMAN 0.401165 U @@ -161075,7 +160910,6 @@ P5CR3_HUMAN COPG2_HUMAN 0.140780 U PKN1_HUMAN MK09_HUMAN 0.345052 U PKN1_HUMAN HDAC5_HUMAN 0.553333 D PKN1_HUMAN TRAF2_HUMAN 0.601642 U -PKN1_HUMAN PKN1_HUMAN 0.553333 U PKN1_HUMAN ZFAN6_HUMAN 0.140780 U PKN1_HUMAN NFL_HUMAN 0.541763 U PKN1_HUMAN NDF2_HUMAN 0.601642 U @@ -161306,7 +161140,6 @@ G5E9M8_HUMAN RBL1_HUMAN 0.140780 U G5E9M8_HUMAN PRKDC_HUMAN 0.140780 U NFYC_HUMAN COBA1_HUMAN 0.401165 U RBM38_HUMAN ZN363_HUMAN 0.367850 U -M4K3_HUMAN M4K3_HUMAN 0.773333 U NOS2_HUMAN BAG2_HUMAN 0.401165 U NOS2_HUMAN CUL5_HUMAN 0.713178 U NOS2_HUMAN PRS4_HUMAN 0.401165 U @@ -161476,7 +161309,6 @@ IMA5_HUMAN PLRG1_HUMAN 0.401165 U IMA5_HUMAN RAG1_HUMAN 0.590561 U CDK2_HUMAN NUCL_HUMAN 0.666667 D CDK2_HUMAN B4DWW4_HUMAN 0.676128 U -CDK2_HUMAN CDK2_HUMAN 0.553333 U CDK2_HUMAN PSMD9_HUMAN 0.401165 U CDK2_HUMAN STML1_HUMAN 0.524233 U CDK2_HUMAN RUXF_HUMAN 0.401165 U @@ -161554,7 +161386,6 @@ RUXF_HUMAN LUC7L_HUMAN 0.140780 U LUC7L_HUMAN PLRG1_HUMAN 0.140780 U FER_HUMAN ABI1_HUMAN 0.438873 U FER_HUMAN JAK1_HUMAN 0.140780 U -FER_HUMAN FER_HUMAN 0.730000 U LSM6_HUMAN ICLN_HUMAN 0.507011 U LSM6_HUMAN Q6FHY4_HUMAN 0.345052 U RS9_HUMAN RS2_HUMAN 0.563535 U @@ -161615,7 +161446,6 @@ PRS4_HUMAN PRS8_HUMAN 0.812232 U PRS4_HUMAN F1D8N6_HUMAN 0.140780 U PRS4_HUMAN FKBP8_HUMAN 0.676128 U WWC3_HUMAN TRM7_HUMAN 0.401165 U -FLT3_HUMAN FLT3_HUMAN 0.886667 U FLT3_HUMAN PTN6_HUMAN 0.140780 U AKT1_HUMAN NOS3_HUMAN 0.840000 D EXOS6_HUMAN RRP44_HUMAN 0.140780 U @@ -161703,7 +161533,6 @@ SRP14_HUMAN NPL4_HUMAN 0.401165 U TBB1_HUMAN CUL5_HUMAN 0.401165 U CD3Z_HUMAN LAT_HUMAN 0.401165 U AKT1_HUMAN TRMB_HUMAN 0.773333 D -AKT1_HUMAN AKT1_HUMAN 0.620000 U AKT1_HUMAN RS3_HUMAN 0.553333 D PRKDC_HUMAN AKT1_HUMAN 0.553333 D AKT1_HUMAN RICTR_HUMAN 0.663333 D @@ -161729,7 +161558,6 @@ TAF1_HUMAN RBL1_HUMAN 0.401165 U TAF1_HUMAN GFI1B_HUMAN 0.405558 U TAF1_HUMAN L7RT22_HUMAN 0.367850 U CDK3_HUMAN CKS2_HUMAN 0.140780 U -TPD54_HUMAN TPD54_HUMAN 0.367850 U RBL1_HUMAN DGKZ_HUMAN 0.524233 U ABI1_HUMAN PR40A_HUMAN 0.401165 U SNF8_HUMAN RILP_HUMAN 0.438873 U @@ -161766,7 +161594,6 @@ PA2G4_HUMAN ATR_HUMAN 0.309917 U PA2G4_HUMAN HDAC5_HUMAN 0.401165 U KAT2B_HUMAN F1D8N1_HUMAN 0.469622 U KAT2B_HUMAN TFE2_HUMAN 0.169068 U -MELK_HUMAN MELK_HUMAN 0.996667 U RRP44_HUMAN TBL1R_HUMAN 0.140780 U Q6SL56_HUMAN ARRS_HUMAN 0.140780 U G3V0I6_HUMAN AGAL_HUMAN 0.401165 U @@ -161820,7 +161647,6 @@ PRKDC_HUMAN CUL5_HUMAN 0.401165 U PRKDC_HUMAN HDAC5_HUMAN 0.401165 U PRKDC_HUMAN TPR_HUMAN 0.345052 U PRKDC_HUMAN LMNA_HUMAN 0.401165 U -PRKDC_HUMAN PRKDC_HUMAN 0.976667 U ATG3_HUMAN E7EVC7_HUMAN 0.401165 U VDR_HUMAN PRS8_HUMAN 0.405558 U VDR_HUMAN BAZ1B_HUMAN 0.743916 U @@ -161843,24 +161669,18 @@ UPAR_HUMAN JAK1_HUMAN 0.615389 U PHLP2_HUMAN EZRI_HUMAN 0.401165 U NRF1_HUMAN PARP1_HUMAN 0.438873 U MARK3_HUMAN E9KL36_HUMAN 0.447879 U -MARK3_HUMAN MARK3_HUMAN 0.700000 U MARK3_HUMAN HDAC5_HUMAN 0.401165 U MARK3_HUMAN ASB13_HUMAN 0.581847 U MARK3_HUMAN MARK2_HUMAN 0.401165 U MARK3_HUMAN PLPL2_HUMAN 0.447879 U Q6PIL8_HUMAN FA8_HUMAN 0.140780 U -ATR_HUMAN ATR_HUMAN 0.553333 U SP3_HUMAN TFAP4_HUMAN 0.401165 U NOE2_HUMAN ROBO2_HUMAN 0.511680 U -RAF1_HUMAN RAF1_HUMAN 0.886667 U LMNA_HUMAN NPL4_HUMAN 0.401165 U LMNA_HUMAN KAT5_HUMAN 0.447879 U -LMNA_HUMAN LMNA_HUMAN 0.260150 U LMNA_HUMAN PARP1_HUMAN 0.401165 U -KAT2A_HUMAN KAT2A_HUMAN 0.367850 U BAG2_HUMAN HDAC5_HUMAN 0.401165 U MARK2_HUMAN HDAC5_HUMAN 0.663333 D -MARK2_HUMAN MARK2_HUMAN 0.553333 U CKS2_HUMAN SPB1_HUMAN 0.140780 U CKS2_HUMAN GO45_HUMAN 0.367850 U K2C3_HUMAN CUL5_HUMAN 0.401165 U @@ -161884,7 +161704,6 @@ OGFD1_HUMAN EZRI_HUMAN 0.401165 U TBL1R_HUMAN HDAC5_HUMAN 0.589229 U FKBP8_HUMAN UCRI_HUMAN 0.345052 U FKBP8_HUMAN PRS8_HUMAN 0.401165 U -TGFR2_HUMAN TGFR2_HUMAN 0.866667 U IL2RB_HUMAN JAK1_HUMAN 0.954229 U B4DWW4_HUMAN HDAC5_HUMAN 0.401165 U A4D1Q0_HUMAN ARRS_HUMAN 0.234063 U @@ -161897,5 +161716,4 @@ PRS8_HUMAN HDAC5_HUMAN 0.401165 U SPB4_HUMAN CP045_HUMAN 0.140780 U ITSN1_HUMAN A8K287_HUMAN 0.140780 U ICAM1_HUMAN EZRI_HUMAN 0.665253 U -RIPK2_HUMAN RIPK2_HUMAN 0.840000 U RIPK2_HUMAN EZRI_HUMAN 0.401165 U