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I was wondering if it would be possible to use scDesign3 to modify a set of genes for a set of cells from a real scRNAseq dataset to create a synthetic dataset? If so, how? Thanks very much!
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I did not fully get your question. I think you can select some genes and cells and only fit the model on this submatrix, and then alter the model. Please check our step-by-step mode in our vignittee.
@SONGDONGYUAN1994 Thanks for your quick response. Sorry if I didn't describe my question clear enough for you. What I really want to do is to create a new cell type in the simulated data by modifying a set of genes from the existing real dataset. Do you think scDesign3 can do that? Thank you! Following your tutorial here https://songdongyuan1994.github.io/scDesign3/docs/articles/scDesign3-cellType-vignette.html, it seems that scDesgin3 can only take a real dataset and create a synthetic with the same cell types or varying their cell type proportions. Could scDesign create a new cell type from real data? Thank you!
Hello!
I was wondering if it would be possible to use scDesign3 to modify a set of genes for a set of cells from a real scRNAseq dataset to create a synthetic dataset? If so, how? Thanks very much!
The text was updated successfully, but these errors were encountered: