+
Pharos Class
-
{{ gene.druggability[0].pharos_class }}
+
{{ gene.druggability.pharos_class.join(', ') }}
Also known as
diff --git a/src/app/features/genes/components/gene-nominated-targets/gene-nominated-targets.component.ts b/src/app/features/genes/components/gene-nominated-targets/gene-nominated-targets.component.ts
index 8ba8aebb..d50d9e36 100644
--- a/src/app/features/genes/components/gene-nominated-targets/gene-nominated-targets.component.ts
+++ b/src/app/features/genes/components/gene-nominated-targets/gene-nominated-targets.component.ts
@@ -119,13 +119,7 @@ export class GeneNominatedTargetsComponent implements OnInit {
: undefined;
// Populate Druggability display fields
- if (de.druggability && de.druggability.length) {
- de.pharos_class_display_value = de.druggability[0].pharos_class
- ? de.druggability[0].pharos_class
- : 'No value';
- } else {
- de.pharos_class_display_value = 'No value';
- }
+ de.pharos_class_display_value = de.druggability.pharos_class;
});
this.genes = genes;
diff --git a/src/app/features/genes/components/gene-similar/gene-similar.component.ts b/src/app/features/genes/components/gene-similar/gene-similar.component.ts
index 3bcb4159..4135149f 100644
--- a/src/app/features/genes/components/gene-similar/gene-similar.component.ts
+++ b/src/app/features/genes/components/gene-similar/gene-similar.component.ts
@@ -107,13 +107,7 @@ export class GeneSimilarComponent implements OnInit {
de.nominated_target_display_value = false;
// Populate Druggability display fields
- if (de.druggability && de.druggability.length) {
- de.pharos_class_display_value = de.druggability[0].pharos_class
- ? de.druggability[0].pharos_class
- : 'No value';
- } else {
- de.pharos_class_display_value = 'No value';
- }
+ de.pharos_class_display_value = de.druggability.pharos_class;
});
this.genes = genes;
diff --git a/src/app/models/genes.ts b/src/app/models/genes.ts
index f7ea1958..f7ba2e8f 100644
--- a/src/app/models/genes.ts
+++ b/src/app/models/genes.ts
@@ -23,7 +23,6 @@ export interface TargetNomination {
input_data: string;
validation_study_details: string;
initial_nomination: number;
- //
team_data?: Team;
}
@@ -41,7 +40,7 @@ export interface Druggability {
sm_druggability_bucket: number;
safety_bucket: number;
abability_bucket: number;
- pharos_class: string;
+ pharos_class: string[];
// classification should really be named sm_druggability_bucket_definition
classification: string;
safety_bucket_definition: string;
@@ -64,7 +63,7 @@ export interface Gene {
protein_brain_change_studied: boolean;
target_nominations: TargetNomination[] | null;
median_expression: MedianExpression[];
- druggability: Druggability[];
+ druggability: Druggability;
total_nominations: number | null;
is_adi: boolean;
is_tep: boolean;
@@ -85,7 +84,7 @@ export interface Gene {
similar_genes_network?: SimilarGenesNetwork;
// Similar table (not in mongo document)
- pharos_class_display_value?: string;
+ pharos_class_display_value?: string[];
is_any_rna_changed_in_ad_brain_display_value?: string;
is_any_protein_changed_in_ad_brain_display_value?: string;
nominated_target_display_value?: boolean;
diff --git a/src/app/testing/gene-mocks.ts b/src/app/testing/gene-mocks.ts
index 3ba576d3..0edc07b0 100644
--- a/src/app/testing/gene-mocks.ts
+++ b/src/app/testing/gene-mocks.ts
@@ -205,20 +205,18 @@ export const geneMock1: Gene = {
tissue: 'STG',
},
],
- druggability: [
- {
- sm_druggability_bucket: 3,
- safety_bucket: 4,
- abability_bucket: 3,
- pharos_class: 'Tbio',
- classification:
- 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
- safety_bucket_definition:
- 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
- abability_bucket_definition:
- 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
- },
- ],
+ druggability: {
+ sm_druggability_bucket: 3,
+ safety_bucket: 4,
+ abability_bucket: 3,
+ pharos_class: ['Tbio'],
+ classification:
+ 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
+ safety_bucket_definition:
+ 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
+ abability_bucket_definition:
+ 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
+ },
total_nominations: 5,
rna_differential_expression: [
{
@@ -3129,20 +3127,18 @@ export const geneMock2: Gene = {
tissue: 'STG',
},
],
- druggability: [
- {
- sm_druggability_bucket: 3,
- safety_bucket: 4,
- abability_bucket: 3,
- pharos_class: 'Tbio',
- classification:
- 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
- safety_bucket_definition:
- 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
- abability_bucket_definition:
- 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
- },
- ],
+ druggability: {
+ sm_druggability_bucket: 3,
+ safety_bucket: 4,
+ abability_bucket: 3,
+ pharos_class: ['Tbio'],
+ classification:
+ 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
+ safety_bucket_definition:
+ 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
+ abability_bucket_definition:
+ 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
+ },
total_nominations: 3,
is_adi: false,
is_tep: true,
@@ -3257,20 +3253,18 @@ export const geneMock3: Gene = {
tissue: 'STG',
},
],
- druggability: [
- {
- sm_druggability_bucket: 3,
- safety_bucket: 4,
- abability_bucket: 3,
- pharos_class: 'Tbio',
- classification:
- 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
- safety_bucket_definition:
- 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
- abability_bucket_definition:
- 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
- },
- ],
+ druggability: {
+ sm_druggability_bucket: 3,
+ safety_bucket: 4,
+ abability_bucket: 3,
+ pharos_class: ['Tbio'],
+ classification:
+ 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
+ safety_bucket_definition:
+ 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
+ abability_bucket_definition:
+ 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
+ },
total_nominations: null,
is_adi: false,
is_tep: true,
@@ -3441,20 +3435,18 @@ export const nominatedGeneMock1: Gene = {
},
],
median_expression: [],
- druggability: [
- {
- sm_druggability_bucket: 3,
- safety_bucket: 4,
- abability_bucket: 3,
- pharos_class: 'Tbio',
- classification:
- 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
- safety_bucket_definition:
- 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
- abability_bucket_definition:
- 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
- },
- ],
+ druggability: {
+ sm_druggability_bucket: 3,
+ safety_bucket: 4,
+ abability_bucket: 3,
+ pharos_class: ['Tbio'],
+ classification:
+ 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
+ safety_bucket_definition:
+ 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
+ abability_bucket_definition:
+ 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
+ },
total_nominations: 4,
is_adi: false,
is_tep: false,
@@ -3544,20 +3536,18 @@ export const noHGNCgeneMock: Gene = {
},
],
median_expression: [],
- druggability: [
- {
- sm_druggability_bucket: 3,
- safety_bucket: 4,
- abability_bucket: 3,
- pharos_class: 'Tbio',
- classification:
- 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
- safety_bucket_definition:
- 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
- abability_bucket_definition:
- 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
- },
- ],
+ druggability: {
+ sm_druggability_bucket: 3,
+ safety_bucket: 4,
+ abability_bucket: 3,
+ pharos_class: ['Tbio'],
+ classification:
+ 'Targetable by structure: Structurally druggable protein, based on the presence of a druggable pocket in the protein (DrugEBIlity/CanSAR).',
+ safety_bucket_definition:
+ 'More than two of: high off target gene expression, cancer driver, essential gene, associated deleterious genetic disorder, HPO phenotype associated gene, or black box warning on clinically used drug.',
+ abability_bucket_definition:
+ 'Cell membrane-bound proteins. Highly accessible to antibody-based therapies, but potentially less so than secreted proteins or ECM components.',
+ },
total_nominations: 4,
is_adi: false,
is_tep: false,
diff --git a/src/server/models/genes.ts b/src/server/models/genes.ts
index aea8b9e3..e714e078 100644
--- a/src/server/models/genes.ts
+++ b/src/server/models/genes.ts
@@ -53,7 +53,7 @@ const DruggabilitySchema = new Schema({
sm_druggability_bucket: { type: Number, required: true },
safety_bucket: { type: Number, required: true },
abability_bucket: { type: Number, required: true },
- pharos_class: { type: String, required: true },
+ pharos_class: { type: [String], required: true },
classification: { type: String, required: true },
safety_bucket_definition: { type: String, required: true },
abability_bucket_definition: { type: String, required: true },
@@ -76,7 +76,7 @@ const GeneSchema = new Schema(
protein_brain_change_studied: { type: Boolean, required: true },
target_nominations: { type: [TargetNominationSchema], required: true },
median_expression: { type: [MedianExpressionSchema], required: true },
- druggability: { type: [DruggabilitySchema], required: true },
+ druggability: { type: DruggabilitySchema, required: true },
total_nominations: { type: Number, required: true },
ensembl_info: { type: EnsemblInfoSchema, required: true }
},