GPR curation for Transport reactions (7)

[JHL-452b]

Current behavior:

45 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000103064	Q92536	MAR05800: homoserine + Na+ + serine --> homoserine + Na+ + serine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The reactions catalyzed by the gene ENSG00000103064 involve the exchange of L-arginine with various other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in a sodium-dependent manner. However, the given reaction involves homoserine, serine, and sodium, which are not mentioned in the gene's catalytic activities. Therefore, based on the gene's annotation, it is clear that the gene does not catalyze the provided reaction.	No
ENSG00000103064	Q92536	MAR05803: homoserine + Na+ + phenylalanine --> homoserine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine and L-glutamine, often in the presence of sodium ions. The reactions it catalyzes involve specific amino acids and sodium ions, such as L-arginine with L-lysine or L-leucine. However, the provided reaction involves homoserine, sodium, and phenylalanine, which are not among the substrates or products associated with the gene's described functions. Therefore, the gene and the provided reaction are not related.	No
ENSG00000103064	Q92536	MAR05804: homoserine + Na+ + tyrosine --> homoserine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter, exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and others, often in a sodium-dependent manner. The catalytic activities detailed for the gene do not include interactions with homoserine or tyrosine. The reaction provided (homoserine + Na+ + tyrosine --> homoserine + Na+ + tyrosine) does not involve the transport or exchange mechanisms associated with the gene, indicating no functional relevance.	No
ENSG00000103064	Q92536	MAR05805: cysteine + homoserine + Na+ --> cysteine + homoserine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an amino acid antiporter, facilitating the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, or L-methionine, along with sodium ions. The provided reaction involves the interaction between cysteine and homoserine in the presence of sodium ions, which is not part of the catalytic activities attributed to the gene. Therefore, there is no direct link between the gene¡¯s function and the provided reaction.	No
ENSG00000103064	Q92536	MAR05806: homoserine + leucine + Na+ --> homoserine + leucine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the transport of amino acids, specifically operating as an antiporter that exchanges cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and others, often in a sodium-dependent manner. The catalytic activities described indicate specific exchanges involving L-arginine and various other amino acids, but none of these processes involve the reaction of homoserine with leucine and sodium ions. Therefore, the gene's functions do not align with the provided reaction.	No
ENSG00000103064	Q92536	MAR05808: asparagine + homoserine + Na+ --> asparagine + homoserine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of cationic amino acids (e.g., L-arginine) and neutral amino acids (e.g., L-leucine, L-glutamine), often in a sodium-dependent manner. The catalytic activities described involve exchanges such as L-arginine with L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, with each process either being sodium-dependent or independent. However, the reaction provided involves asparagine and homoserine, which are not mentioned in the catalytic activities or functional description of the gene product. Therefore, based on the annotation, the gene and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05809: homoserine + Na+ + valine --> homoserine + Na+ + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of various amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, often in exchange with sodium ions. The provided reaction "homoserine + Na+ + valine --> homoserine + Na+ + valine" does not involve any of these transport processes or amino acids that the gene ENSG00000103064 interacts with. Therefore, the gene's function and the reaction are not related.	No
ENSG00000103064	Q92536	MAR05813: alanine + isoleucine + Na+ --> alanine + isoleucine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. According to the gene annotation, ENSG00000103064 encodes a protein involved in the exchange of cationic and neutral amino acids, specifically including L-arginine, L-lysine, L-leucine, L-glutamine, and several others, often in conjunction with sodium ions. However, the reaction in question involves alanine, isoleucine, and sodium, which are not among the substrates or products described in the catalytic activities of the gene's encoded protein. Therefore, the gene does not relate to the given reaction.	No
ENSG00000103064	Q92536	MAR05816: isoleucine + methionine + Na+ --> isoleucine + methionine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 codes for a protein that functions as an antiporter for cationic and neutral amino acids, primarily involving L-arginine exchanges with other amino acids such as L-lysine, L-leucine, L-glutamine, and several others, often in a sodium-dependent or sodium-independent manner. The reactions catalyzed by this gene do not align with the provided reaction, which involves isoleucine and methionine interacting with sodium ions, but not through an exchange mechanism or involving L-arginine. Therefore, the gene's functional role and the provided reaction are not related.	No
ENSG00000103064	Q92536	MAR05822: isoleucine + Na+ + proline --> isoleucine + Na+ + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter primarily involved in the exchange of L-arginine with other amino acids like L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, along with sodium ions. The provided reaction, however, involves the exchange of isoleucine, Na+, and proline, which does not match any of the exchanges mediated by the gene's product as per the annotated catalytic activities. Therefore, the gene is not relevant to the specified reaction.	No
ENSG00000103064	Q92536	MAR05824: isoleucine + Na+ + valine --> isoleucine + Na+ + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions as an antiporter for the exchange of cationic amino acids (e.g., L-arginine) with neutral amino acids (e.g., L-leucine, L-glutamine) plus sodium ions. It specifically mediates the transport of L-arginine with various amino acids and operates in a 1:1 stoichiometry. The reaction provided involves the exchange of isoleucine and valine with sodium ions, which is not consistent with the substrate specificity and function of the gene's protein product. Therefore, the gene is unrelated to the given reaction.	No
ENSG00000103064	Q92536	MAR05835: alanine + histidine + Na+ --> alanine + histidine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The provided gene, ENSG00000103064, encodes a protein that functions as a heterodimer with SLC3A2, which is involved in the transport of various amino acids (including L-arginine, L-lysine, L-leucine, L-glutamine) in exchange mechanisms that often include sodium ions. However, the reaction provided (alanine + histidine + Na+ --> alanine + histidine + Na+) does not involve any of the specific amino acids transported by the protein encoded by ENSG00000103064, such as L-arginine or the other mentioned amino acids. Therefore, the gene and the reaction are not related.	No Yes
ENSG00000103064	Q92536	MAR05854: Na+ + ornithine + tryptophan --> Na+ + ornithine + tryptophan	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein that functions primarily as an antiporter exchanging cationic amino acids such as L-arginine with various neutral amino acids and sometimes with L-lysine. It specifically details reactions involving L-arginine and neutral amino acids like L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, including catalytic activities that are dependent or independent of sodium ions. However, the provided reaction involves the transport of Na+, ornithine, and tryptophan, which does not align with the specific amino acids and transport mechanism described for ENSG00000103064. Therefore, the gene's function and annotated reactions do not relate to the provided reaction.	No Yes
ENSG00000103064	Q92536	MAR05862: lysine + Na+ + tyrosine --> lysine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine in exchange reactions, often dependent on sodium ions. The provided reaction (lysine + Na+ + tyrosine --> lysine + Na+ + tyrosine) does not involve any of these specific amino acid exchanges nor the described catalytic activities of the gene product, thus making the gene irrelevant to the reaction.	Yes, Lysine is a cationic amino acid, and tyrosine is a neutral amino acid
ENSG00000103064	Q92536	MAR05876: citrulline + leucine + Na+ --> citrulline + leucine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter, involved in the exchange of cationic amino acids like L-arginine with neutral amino acids such as L-leucine and L-glutamine, among others, often in the presence of sodium ions, according to various PubMed sources. However, the provided reaction involves the transformation of citrulline and leucine with sodium ions, which is not within the catalytic activities or functions described for this gene. Hence, the gene is not related to the reaction provided.	No
ENSG00000103064	Q92536	MAR05877: lysine + Na+ + proline --> lysine + Na+ + proline	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the transport of cationic amino acids such as L-arginine in exchange with neutral amino acids like L-leucine, L-glutamine, isoleucine, etc., in either a sodium-dependent or independent manner. The provided reaction describes the interaction between lysine, Na+, and proline, which does not correspond to any of the catalytic activities or transport mechanisms described for the gene. Thus, the gene and the reaction are not related.	No Yes
ENSG00000103064	Q92536	MAR05886: asparagine + citrulline + Na+ --> asparagine + citrulline + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter, mediating the exchange of L-arginine with various neutral amino acids such as L-leucine, L-glutamine, L-isoleucine, L-histidine, L-cysteine, and L-methionine in conjunction with sodium ions. However, the provided reaction involves asparagine and citrulline in the presence of sodium ions, which does not align with any of the described substrate specificities or catalytic activities of the gene product. Therefore, the gene is not related to the described reaction.	No
ENSG00000103064	Q92536	MAR05899: homoserine + Na+ + ornithine --> homoserine + Na+ + ornithine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the provided annotation, the gene ENSG00000103064 encodes a protein that operates as an antiporter, facilitating the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and other amino acids, typically in a sodium-dependent or sodium-independent manner. The provided reaction, "homoserine + Na+ + ornithine --> homoserine + Na+ + ornithine," does not involve the exchange of these specific amino acids and does not match any of the catalytic activities described for the gene. Therefore, this gene's function is unrelated to the reaction given.	Yes, ornithine is a cationic amino acid, and homoserine is a neutral amino acid
ENSG00000021488	P82251	MAR05908: alanine + lysine --> alanine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter, facilitating the exchange of various cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided (alanine + lysine --> alanine + lysine) does not involve any of these transport activities or exchanges mediated by the protein encoded by ENSG00000021488. Therefore, based on the gene's function and the specific reactions it catalyzes, it is not relevant to the reaction provided.	Yes
ENSG00000103064	Q92536	MAR05908: alanine + lysine --> alanine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation, the gene ENSG00000103064 functions as an antiporter involved in the exchange of various amino acids, such as L-arginine, L-lysine, L-leucine, and others, and does not participate in the reaction involving alanine and lysine. The gene's specific catalyzed reactions involve different substrates and mechanisms, indicating it does not catalyze the alanine and lysine reaction.	Yes
ENSG00000021488	P82251	MAR05909: glutamine + lysine --> glutamine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter that mediates the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves glutamine and lysine, which is not among the reactions catalyzed by the transporter protein encoded by this gene. Therefore, the gene is not related to the given reaction.	Yes
ENSG00000103064	Q92536	MAR05910: lysine + serine --> lysine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of various amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, typically in a sodium-dependent or sodium-independent manner. The reactions catalyzed by this gene do not involve or mention the direct interaction between lysine and serine as described in the provided reaction "lysine + serine --> lysine + serine". Therefore, the gene's function and catalytic activities are unrelated to the given reaction.	Yes
ENSG00000021488	P82251	MAR05911: lysine + methionine --> lysine + methionine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter mediating the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction described as "lysine + methionine --> lysine + methionine" does not involve any of the catalytic activities or substrate exchanges facilitated by the gene product. Therefore, the gene is not related to the given reaction.	Yes
ENSG00000021488	P82251	MAR05912: lysine + tryptophan --> lysine + tryptophan	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a transporter complex that mediates the exchange between cationic amino acids and neutral amino acids, specifically involving L-arginine with other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves lysine and tryptophan, which does not match any of the known substrates involved in the gene's described catalytic activities. Therefore, based on the annotation, the gene and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05913: lysine + phenylalanine --> lysine + phenylalanine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily involved in the transport of cationic amino acids such as L-arginine in exchange for neutral amino acids like L-leucine, L-glutamine, and others. The catalytic activities mentioned involve L-arginine being exchanged with various other amino acids and sodium ions. However, the provided reaction involves lysine and phenylalanine, which are not linked to the transport functions or catalytic activities of the encoded protein according to the given information.	Yes
ENSG00000021488	P82251	MAR05914: lysine + tyrosine --> lysine + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation of the gene ENSG00000021488, this gene encodes a protein that forms a functional transporter complex involved in the electrogenic exchange of cationic and neutral amino acids, with specific catalytic activities involving amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves lysine and tyrosine without any indication of an exchange mechanism or alignment with the specific activities mediated by the identified transporter. Therefore, the gene's function does not correlate with the reaction given.	Yes
ENSG00000103064	Q92536	MAR05914: lysine + tyrosine --> lysine + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The function of the gene ENSG00000103064 involves the transport and exchange of specific amino acids such as L-arginine, L-leucine, L-glutamine, L-lysine, and others, both in sodium-dependent and sodium-independent manners. However, the reaction lysine + tyrosine --> lysine + tyrosine does not correspond to any transport or exchange activity described for this gene. It is not an amino acid exchange reaction catalyzed by the gene product but rather a simple representation of two amino acids, lysine and tyrosine, that do not interact in a meaningful way within the context provided. Therefore, there is no catalytic activity or function described for the gene that supports the involvement in this reaction.	Yes
ENSG00000021488	P82251	MAR05917: lysine + proline --> lysine + proline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a transporter protein that specifically mediates electrogenic exchanges between various cationic amino acids (e.g., L-arginine) and neutral amino acids (e.g., L-leucine, L-histidine, L-phenylalanine, L-cysteine) with a stoichiometry of 1:1. The annotated catalytic activities involve exchanges of L-arginine with these amino acids. However, the reaction provided (lysine + proline --> lysine + proline) is not an exchange reaction and does not involve the amino acids relevant to the gene's function. Thus, the gene and the reaction are unrelated based on the gene's annotation.	Yes
ENSG00000103064	Q92536	MAR05918: asparagine + lysine --> asparagine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically transporting cationic and neutral amino acids in exchange processes involving L-arginine, L-lysine, L-leucine, L-glutamine, and other amino acids coupled with sodium ions. The annotated catalytic activities are specific to these exchanges. However, the provided reaction involves asparagine and lysine, which does not align with the gene's identified transporter functions and catalytic activities. Therefore, the gene's annotation does not support its relevance to the reaction asparagine + lysine --> asparagine + lysine.	Yes
ENSG00000103064	Q92536	MAR05919: lysine + valine --> lysine + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions as an antiporter for cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, often involving sodium ions. However, the reaction provided (lysine + valine --> lysine + valine) does not match the gene-annotated reactions and catalytic activities, which involve different combinations of amino acids and transport mechanisms, with no involvement of valine as a reactant.	Yes
ENSG00000021488	P82251	MAR05921: homoserine + lysine --> homoserine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is associated with the function of forming a functional transporter complex with SLC3A1, mediating the electrogenic exchange between cationic amino acids and neutral amino acids. The catalytic activities of this gene involve various exchanges between L-arginine and other cationic or neutral amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided (homoserine + lysine --> homoserine + lysine) does not align with the functions or catalytic activities described for the gene. Therefore, the gene and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05921: homoserine + lysine --> homoserine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically involved in the exchange of amino acids, primarily L-arginine, with other amino acids such as L-lysine, L-leucine, L-glutamine, and others, in the presence or absence of sodium ions. It does not catalyze a reaction involving homoserine and lysine as substrates. The provided reaction, where homoserine reacts with lysine to produce homoserine and lysine, does not align with the gene's function of amino acid transport, indicating no relevance.	Yes
ENSG00000103064	Q92536	MAR05926: arginine + serine --> arginine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging cationic amino acids such as L-arginine with neutral amino acids or sodium ions as described in various catalytic activities. However, the reaction provided involves the transformation of arginine and serine, which is not mentioned in the described functions and catalytic activities of the gene product. Therefore, the gene does not appear to be related to the reaction provided.	Yes
ENSG00000021488	P82251	MAR05927: arginine + methionine --> arginine + methionine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is associated with the formation of a transporter complex that mediates the exchange of cationic and neutral amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction involves the exchange of arginine with methionine, which is not included in the known catalytic activities of the gene's associated transporter, hence indicating no relevance between the gene and the reaction.	Yes
ENSG00000021488	P82251	MAR05928: arginine + tryptophan --> arginine + tryptophan	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is responsible for encoding a protein that forms a functional transporter complex with SLC3A1, which mediates the electrogenic exchange between cationic amino acids and neutral amino acids with a stoichiometry of 1:1. The gene's associated transporter specifically facilitates the exchange of amino acids such as L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine, as supported by multiple PubMed references. However, there is no mention or evidence that the transporter mediates an exchange involving tryptophan as described in the given reaction (arginine + tryptophan --> arginine + tryptophan). Therefore, the gene is not relevant to the specified reaction.	Yes
ENSG00000021488	P82251	MAR05936: arginine + threonine --> arginine + threonine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that mediates the exchange between cationic and neutral amino acids, such as arginine, leucine, histidine, phenylalanine, cysteine, cystine, and lysine. However, the reaction provided involves the exchange of arginine and threonine, which is not among the substrates listed for the transporter activity of the gene. Therefore, the gene does not mediate the specific reaction involving threonine, making it irrelevant to the provided reaction.	Yes
ENSG00000021488	P82251	MAR05940: alanine + ornithine --> alanine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is associated with the transport of various amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine, based on electrogenic exchange between cationic and neutral amino acids. However, the reaction provided, which involves the conversion of alanine and ornithine into alanine and ornithine, does not involve any of these specific amino acid exchanges mentioned in the gene's catalytic activities. Therefore, there is no direct relevance between the gene and the provided reaction.	Yes
ENSG00000103064	Q92536	MAR05940: alanine + ornithine --> alanine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of specific amino acids, functioning as an antiporter that exchanges cationic amino acids such as L-arginine for neutral amino acids and sodium ions. The gene does not play a role in the reaction "alanine + ornithine --> alanine + ornithine," which does not involve the transport mechanisms or specific amino acid exchanges described in the gene's function.	Yes
ENSG00000021488	P82251	MAR05941: glutamine + ornithine --> glutamine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the exchange of cationic amino acids and neutral amino acids, such as L-arginine and L-leucine, L-arginine and L-histidine, L-arginine and L-phenylalanine, etc. However, the provided reaction, which is glutamine and ornithine forming glutamine and ornithine, does not involve any cationic amino acids or neutral amino acids exchanged by the gene's transporter activity. Therefore, the gene is not relevant to the reaction provided.	Yes
ENSG00000021488	P82251	MAR05942: ornithine + serine --> ornithine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 functions in the electrogenic exchange of cationic and neutral amino acids, specifically involving substrates like L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The described catalytic activities involve amino acid exchanges driven by concentration gradients and reduction reactions. However, the specified reaction ("ornithine + serine --> ornithine + serine") does not involve any of the substrates or exchange mechanisms associated with the gene's known functions. Thus, the gene does not play a role in the provided reaction.	Yes
ENSG00000021488	P82251	MAR05946: ornithine + tyrosine --> ornithine + tyrosine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that functions as part of a transporter complex responsible for the electrogenic exchange between cationic amino acids and neutral amino acids, specifically mediating exchanges involving L-arginine and various other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The reactions catalyzed by this gene do not involve ornithine and tyrosine, which are the substrates mentioned in the provided reaction. Therefore, the gene ENSG00000021488 is not relevant to the reaction involving ornithine and tyrosine.	Yes
ENSG00000103064	Q92536	MAR05947: cysteine + ornithine --> cysteine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily involved in the exchange of L-arginine with various other amino acids (e.g., L-lysine, L-leucine) and sodium ions. The catalytic activities provided describe reactions involving L-arginine exchanges, whereas the given reaction (cysteine + ornithine --> cysteine + ornithine) does not involve L-arginine or the specific exchanges described for the gene product. Therefore, the gene is not related to the provided reaction.	Yes
ENSG00000021488	P82251	MAR05951: ornithine + valine --> ornithine + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter for various cationic and neutral amino acids, facilitating their exchange with a specific stoichiometry of 1:1. The documented catalytic activities involve the transport of L-arginine in exchange for several other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided, "ornithine + valine --> ornithine + valine," does not match any of the documented substrate exchanges or catalytic activities associated with the gene. Therefore, based on the functional and catalytic annotation, the gene is not related to the reaction mentioned.	Yes
ENSG00000103064	Q92536	MAR05953: homoserine + ornithine --> homoserine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of L-arginine with various neutral and cationic amino acids, and possibly sodium ions, within the cell. The gene's annotated activities include the exchange of L-amino acids such as L-leucine, L-glutamine, and L-lysine, which are directly involved in various metabolic processes related to amino acid transport and nitric oxide synthesis. However, the provided reaction involves homoserine and ornithine, which do not appear to be substrates or products of the gene's encoded protein functions. Therefore, the gene's function does not include or relate to the reaction given.	Yes
ENSG00000021488	P82251	MAR05954: isoleucine + ornithine --> isoleucine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as an amino acid transporter, specifically mediating the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, and L-cystine. The described catalytic activities do not include the reaction involving isoleucine and ornithine. Therefore, based on the gene's annotated function and its specific substrate affinities, it is not involved in the reaction isoleucine + ornithine --> isoleucine + ornithine.	Yes

[hhl-24]

Keep ENSG00000103064 for MAR05835: alanine + histidine + Na+ --> alanine + histidine + Na+, MAR05854: Na+ + ornithine + tryptophan --> Na+ + ornithine + tryptophan, MAR05877: lysine + Na+ + proline --> lysine + Na+ + proline , the gene functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids.

[JHL-452b]

Agree to keep ENSG00000103064 for MAR05835, MAR05854 and MAR05877.

[JHL-452b]

There are lots of transport reactions of amino acids. Both @hhl-24 and me get many different results compared with AI. Could you please review this issue from a more professional perspective? @feiranl

[feiranl]

Cationic amino acids, which carry positive charges at physiological pH, include lysine and arginine, both consistently positively charged, and histidine, which may be partially protonated depending on the local pH.
Neutral amino acids, which have uncharged side chains at physiological pH, include polar amino acids like serine, threonine, asparagine, glutamine, and tyrosine, as well as nonpolar amino acids like glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, and proline. Thus, as long as the rxn involved these two kinds of rxn excahnge, then it is ok to keep. So I agree.

[feiranl]

Please go ahead to make those changes