diff --git a/content/03.results.md b/content/03.results.md index ebcc3539..c4c997e0 100644 --- a/content/03.results.md +++ b/content/03.results.md @@ -203,7 +203,7 @@ We suggest this classifier could be generally applied to infer _TP53_ function i We used gene expression data to predict telomerase activity using EXpression-based Telomerase ENzymatic activity Detection (`EXTEND`) [@doi:10.1038/s41467-020-20474-9] as a surrogate measure of malignant potential [@doi:10.1038/s41467-020-20474-9; @doi:10.1093/carcin/bgp268], where higher `EXTEND` scores indicate higher telomerase activity. Aggressive tumors such as DMGs, other HGGs, and MB had high `EXTEND` scores (**Figure {@fig:Fig4}D**), and low-grade lesions such as schwannomas, GNGs, DNETs, and other LGGs had among the lowest scores (**Table S3**), supporting previous reports that aggressive tumor phenotypes have higher telomerase activity [@doi:10.1007/s13277-016-5045-7; @doi:10.1038/labinvest.3700710; @doi:10.1007/s12032-016-0736-x; @doi:10.1111/j.1750-3639.2010.00372.x]. While `EXTEND` scores were not significantly higher in tumors with _TERT_ promoter (TERTp) mutations (N = 6; Wilcoxon p-value = 0.1196), scores were significantly correlated with _TERC_ (R = 0.619, p < 0.01) and _TERT_ (R = 0.491, p < 0.01) log2 FPKM expression values (**Figure {@fig:S5}B-C**). -Since catalytically-active telomerase requires full-length _TERT_, _TERC_, and certain accessory proteins [@pmid:9751630], we expect that `EXTEND` scores may not be exclusively correlated with _TERT_ alterations and expression. +Since catalytically-active telomerase requires full-length _TERT_, _TERC_, and certain accessory proteins [@pubmed:9751630], we expect that `EXTEND` scores may not be exclusively correlated with _TERT_ alterations and expression. #### Hypermutant tumors share mutational signatures and have dysregulated **_TP53_** diff --git a/content/manual-references.json b/content/manual-references.json index 90acc6e6..790d6042 100644 --- a/content/manual-references.json +++ b/content/manual-references.json @@ -363,7 +363,7 @@ } }, { - "id": "pmid:26389418", + "id": "pubmed:26389418", "type": "chapter", "title": "Childhood Medulloblastoma and Other Central Nervous System Embryonal Tumors Treatment (PDQ®): Health Professional Version", "container-title": "PDQ Cancer Information Summaries",