From 0252dd895cd1b6fcb2b8a0ac7433ca5aa8e88360 Mon Sep 17 00:00:00 2001 From: Sarah Davidson-Fritz Date: Wed, 7 Feb 2024 10:06:27 -0500 Subject: [PATCH] update the NEWS file to add in the Fabsgut variable change not previously provided in the NEWS file and provide better clarification --- httk/NEWS.md | 4 ++++ 1 file changed, 4 insertions(+) diff --git a/httk/NEWS.md b/httk/NEWS.md index e13b92aa..54d4e54e 100644 --- a/httk/NEWS.md +++ b/httk/NEWS.md @@ -39,6 +39,10 @@ permeability chemicals and therefore predicts only three values for calculating systemic bioavailability as ***Fbio = Fabs * Fgut * Fhep*** where first-pass hepatic metabolism was already available from `calc_hep_bioavailability`. +* Changed the name of the variable describing fraction absorbed from the gut +prior to first-pass hepatic metabolism to ***Fabsgut*** to reflect that +***Fabs*** and ***Fgut*** are now modeled separately +(that is, ***Fabsgut = Fabs * Fgut***). * Integrated ***Fabs*** and ***Fgut*** into oral exposure for all TK models and integrated into population variability and uncertainty functions within `invitro_uv`