diff --git a/README.md b/README.md
index af11ad99d..af00fee25 100644
--- a/README.md
+++ b/README.md
@@ -109,6 +109,7 @@ KeywordDetector
 MailchimpDetector
 NpmDetector
 PrivateKeyDetector
+PypiTokenDetector
 SendGridDetector
 SlackDetector
 SoftlayerDetector
diff --git a/detect_secrets/plugins/pypi_token.py b/detect_secrets/plugins/pypi_token.py
new file mode 100644
index 000000000..5b0b2a5ed
--- /dev/null
+++ b/detect_secrets/plugins/pypi_token.py
@@ -0,0 +1,20 @@
+"""
+This plugin searches for PyPI tokens
+"""
+import re
+
+from detect_secrets.plugins.base import RegexBasedDetector
+
+
+class PypiTokenDetector(RegexBasedDetector):
+    """Scans for PyPI tokens."""
+    secret_type = 'PyPI Token'
+
+    denylist = [
+        # refs https://warehouse.pypa.io/development/token-scanning.html
+        # pypi.org token
+        re.compile(r'pypi-AgEIcHlwaS5vcmc[A-Za-z0-9-_]{70,}'),
+
+        # test.pypi.org token
+        re.compile(r'pypi-AgENdGVzdC5weXBpLm9yZw[A-Za-z0-9-_]{70,}'),
+    ]
diff --git a/tests/plugins/pypi_token_test.py b/tests/plugins/pypi_token_test.py
new file mode 100644
index 000000000..5854b651c
--- /dev/null
+++ b/tests/plugins/pypi_token_test.py
@@ -0,0 +1,29 @@
+import pytest
+
+from detect_secrets.plugins.pypi_token import PypiTokenDetector
+
+
+class TestPypiTokenDetector:
+
+    @pytest.mark.parametrize(
+        'payload, should_flag',
+        [
+            (
+                # pragma: allowlist nextline secret
+                'pypi-AgEIcHlwaS5vcmcCJDU3OTM1MjliLWIyYTYtNDEwOC05NzRkLTM0MjNiNmEwNWIzYgACF1sxLFsitesttestbWluaW1hbC1wcm9qZWN0Il1dAAIsWzIsWyJjYWY4OTAwZi0xNDMwLTRiYQstYmFmMi1mMDE3OGIyNWZhNTkiXV0AAAYgh2UINPjWBDwT0r3tQ1o5oZyswcjN0-IluP6z34SX3KM', True,  # noqa: E501
+            ),
+            (
+                # pragma: allowlist nextline secret
+                'pypi-AgENdGVzdC5weXBpLm9yZwIkN2YxOWZhOWEtY2FjYS00MGZhLTj2MGEtODFjMnE2MjdmMzY0AAIqWzMsImJlM2FiOWI5LTRmYUTnNEg4ZS04Mjk0LWFlY2Y2NWYzNGYzNyJdAAAGIMb5Hb8nVvhcAizcVVzA-bKKnwN7Pe0RmgPRCvrPwyJf', True,  # noqa: E501
+            ),
+            (
+                # pragma: allowlist nextline secret
+                'pypi-AgEIcHlwaS5vcmcCJDU3OTM1MjliLWIyYTYtNDEwOC05NzRkLTM0MjNiNmEwNWIzYgACF1sxLFsibWluaW1h', False,  # noqa: E501
+            ),
+        ],
+    )
+    def test_analyze(self, payload, should_flag):
+        logic = PypiTokenDetector()
+        output = logic.analyze_line(filename='mock_filename', line=payload)
+
+        assert len(output) == int(should_flag)