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Causal analysis with longitudinal data and time-dependent exposure using R: A package review

  • Traced the evolution of causal inference from Wright's path diagrams in 1920 to the introduction of robust methods like TMLE by Van Der Laan and Rubin in 2006.
  • Assessed R packages gfoRmula, ltmle, and Weightit, each implementing G-computation, TMLE, and MSM, for causal effect estimation.
  • Identified barriers in biostatistics knowledge translation, such as lack of expertise and user-friendly software.
  • Conducted simulations to compare methods across 1,000 iterations, summarizing performance in terms of bias, standard error, and confidence interval coverage.
  • Found TMLE to exhibit statistical power and robustness, despite its higher standard error in binary outcome data.
  • Recommended the ltmle package for longitudinal causal analysis due to its documentation and robust performance.

Future steps:

  • Additional simulation for Bayesian Marginal Structural Model
  • Finishing manuscript for publication