From a34f517c2f02357a1d2783d80eb4222b7066e90a Mon Sep 17 00:00:00 2001 From: rsingle Date: Wed, 16 Aug 2017 07:34:46 -0700 Subject: [PATCH] data & results from NMDP 10k caucasian for HLA-A & -B --- src/emhaplofreq/NCAU_10k_2loc.dat | 10001 +++++++++++++++++++++++++++ src/emhaplofreq/out.NCAU10k_UVM | 1096 +++ src/emhaplofreq/out.NCAU10k_laptop | 1095 +++ 3 files changed, 12192 insertions(+) create mode 100755 src/emhaplofreq/NCAU_10k_2loc.dat create mode 100755 src/emhaplofreq/out.NCAU10k_UVM create mode 100644 src/emhaplofreq/out.NCAU10k_laptop diff --git a/src/emhaplofreq/NCAU_10k_2loc.dat b/src/emhaplofreq/NCAU_10k_2loc.dat new file mode 100755 index 000000000..ae334119b --- /dev/null +++ b/src/emhaplofreq/NCAU_10k_2loc.dat @@ -0,0 +1,10001 @@ +id pop_no a_1 a_2 b_1 +240404 02 02 39 51 +410777 02 31 40 44 +19876 01 68 27 57 +346109 02 11 15 40 +91405 01 03 18 57 +311404 01 25 13 18 +186892 02 02 27 40 +138242 02 33 08 14 +83484 01 02 35 58 +419182 01 23 07 08 +341976 03 03 14 18 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+387935 01 33 40 58 +180489 23 24 18 35 +397814 01 11 08 27 +105719 02 29 35 44 +344482 02 03 07 15 +11174 02 11 44 35 +172177 01 31 57 40 +231413 02 69 27 51 +307882 02 26 27 49 +354396 02 24 35 35 +142527 01 03 18 35 +287914 30 01 13 44 +298082 01 03 37 38 +422807 02 68 38 41 +361132 32 24 40 55 +8519 01 03 35 57 +133417 01 33 53 57 +165607 02 29 07 44 +261426 01 02 50 08 +294067 02 03 44 51 +160928 02 24 50 07 diff --git a/src/emhaplofreq/out.NCAU10k_UVM b/src/emhaplofreq/out.NCAU10k_UVM new file mode 100755 index 000000000..159e33791 --- /dev/null +++ b/src/emhaplofreq/out.NCAU10k_UVM @@ -0,0 +1,1096 @@ +num_loci: 2 +Sample Size (n): 10000 +n_unique_pheno: 4045 +n_unique_geno: 7379 +n_haplo: 448 + +Log likelihood under no LD: -87778.080012 +Log likelihood converged in 65 iterations to : -82313.276462 +Sum of haplotype frequencies = 1.000000 + + Approx No. + MLE Freq* of Copies Haplo (*only printed if MLE > .000005) + 1 0.08129822 1626.0 01:08: + 2 0.06432298 1286.5 02:44: + 3 0.05791149 1158.2 03:07: + 4 0.03898944 779.8 02:07: + 5 0.03282683 656.5 02:15: + 6 0.02977927 595.6 02:40: + 7 0.02528401 505.7 29:44: + 8 0.02205559 441.1 03:35: + 9 0.02009378 401.9 02:51: + 10 0.01738911 347.8 01:57: + 11 0.01550002 310.0 11:35: + 12 0.01513128 302.6 02:27: + 13 0.01453069 290.6 24:07: + 14 0.01374068 274.8 24:35: + 15 0.01166086 233.2 02:08: + 16 0.01157096 231.4 02:18: + 17 0.01145588 229.1 02:35: + 18 0.00997793 199.6 01:07: + 19 0.00980082 196.0 25:18: + 20 0.00960510 192.1 02:57: + 21 0.00953790 190.8 24:15: + 22 0.00890525 178.1 03:44: + 23 0.00850725 170.1 23:44: + 24 0.00836310 167.3 01:37: + 25 0.00833552 166.7 26:38: + 26 0.00789688 157.9 03:14: + 27 0.00785520 157.1 24:44: + 28 0.00784338 156.9 31:40: + 29 0.00771150 154.2 03:15: + 30 0.00733872 146.8 01:35: + 31 0.00728005 145.6 02:39: + 32 0.00723665 144.7 68:44: + 33 0.00705484 141.1 30:13: + 34 0.00676925 135.4 03:40: + 35 0.00671166 134.2 01:44: + 36 0.00650432 130.1 11:07: + 37 0.00636128 127.2 33:14: + 38 0.00631994 126.4 01:15: + 39 0.00601971 120.4 02:50: + 40 0.00601769 120.4 02:13: + 41 0.00574651 114.9 32:44: + 42 0.00569454 113.9 24:40: + 43 0.00530959 106.2 11:51: + 44 0.00530269 106.1 03:27: + 45 0.00520734 104.1 11:44: + 46 0.00506498 101.3 24:18: + 47 0.00499577 99.9 02:49: + 48 0.00498541 99.7 24:51: + 49 0.00488555 97.7 32:40: + 50 0.00480652 96.1 30:18: + 51 0.00475841 95.2 11:55: + 52 0.00468098 93.6 03:51: + 53 0.00464166 92.8 02:14: + 54 0.00461651 92.3 68:14: + 55 0.00446625 89.3 03:18: + 56 0.00423637 84.7 32:15: + 57 0.00419889 84.0 24:27: + 58 0.00411405 82.3 68:35: + 59 0.00396833 79.4 68:40: + 60 0.00391263 78.3 11:40: + 61 0.00382022 76.4 24:39: + 62 0.00380891 76.2 24:55: + 63 0.00370716 74.1 01:18: + 64 0.00358328 71.7 32:35: + 65 0.00356154 71.2 26:27: + 66 0.00344808 69.0 24:08: + 67 0.00338833 67.8 11:27: + 68 0.00329764 66.0 23:49: + 69 0.00321538 64.3 68:51: + 70 0.00310291 62.1 03:08: + 71 0.00301487 60.3 02:38: + 72 0.00292928 58.6 01:51: + 73 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68:07: +109 0.00172698 34.5 31:07: +110 0.00172662 34.5 31:35: +111 0.00172415 34.5 25:08: +112 0.00164302 32.9 26:14: +113 0.00159848 32.0 32:51: +114 0.00159532 31.9 31:44: +115 0.00157369 31.5 03:38: +116 0.00156565 31.3 24:49: +117 0.00155230 31.0 26:51: +118 0.00153397 30.7 03:47: +119 0.00146099 29.2 02:45: +120 0.00144186 28.8 03:57: +121 0.00143834 28.8 01:14: +122 0.00142053 28.4 26:55: +123 0.00140125 28.0 26:15: +124 0.00140092 28.0 11:14: +125 0.00139714 27.9 01:49: +126 0.00138862 27.8 26:40: +127 0.00137322 27.5 68:18: +128 0.00137090 27.4 01:39: +129 0.00132228 26.4 30:35: +130 0.00127838 25.6 33:58: +131 0.00123620 24.7 25:39: +132 0.00120535 24.1 01:38: +133 0.00118992 23.8 03:39: +134 0.00115917 23.2 11:08: +135 0.00113679 22.7 68:08: +136 0.00113396 22.7 26:49: +137 0.00113280 22.7 30:44: +138 0.00112814 22.6 01:58: +139 0.00112590 22.5 29:35: +140 0.00111936 22.4 03:56: +141 0.00104948 21.0 30:08: +142 0.00104314 20.9 29:14: +143 0.00103570 20.7 32:57: +144 0.00099826 20.0 25:07: +145 0.00099031 19.8 32:39: +146 0.00098259 19.7 26:45: +147 0.00098208 19.6 11:56: +148 0.00097977 19.6 03:41: +149 0.00097010 19.4 03:55: +150 0.00094622 18.9 01:55: +151 0.00091794 18.4 32:38: +152 0.00091237 18.2 11:57: +153 0.00090631 18.1 03:50: +154 0.00089249 17.8 23:41: +155 0.00088308 17.7 30:49: +156 0.00086894 17.4 26:37: +157 0.00086693 17.3 24:50: +158 0.00082945 16.6 32:55: +159 0.00081863 16.4 68:39: +160 0.00080746 16.1 23:50: +161 0.00080346 16.1 31:39: +162 0.00080117 16.0 25:58: +163 0.00078287 15.7 25:57: +164 0.00077034 15.4 29:15: +165 0.00072332 14.5 26:18: +166 0.00071874 14.4 25:15: +167 0.00071864 14.4 31:18: +168 0.00071212 14.2 29:27: +169 0.00071197 14.2 33:44: +170 0.00069984 14.0 69:55: +171 0.00069884 14.0 33:35: +172 0.00069120 13.8 23:07: +173 0.00066911 13.4 30:50: +174 0.00066587 13.3 26:08: +175 0.00066183 13.2 29:58: +176 0.00065983 13.2 32:18: +177 0.00065722 13.1 68:38: +178 0.00065124 13.0 31:57: +179 0.00064180 12.8 03:49: +180 0.00063949 12.8 25:40: +181 0.00063058 12.6 30:15: +182 0.00062277 12.5 01:50: +183 0.00062019 12.4 03:37: +184 0.00060600 12.1 68:55: +185 0.00060122 12.0 24:37: +186 0.00059089 11.8 23:15: +187 0.00058203 11.6 25:35: +188 0.00057209 11.4 23:35: +189 0.00057016 11.4 68:57: +190 0.00055725 11.1 33:50: +191 0.00055307 11.1 11:39: +192 0.00054022 10.8 30:41: +193 0.00052458 10.5 01:56: +194 0.00052176 10.4 26:13: +195 0.00050437 10.1 31:08: +196 0.00050224 10.0 30:07: +197 0.00050192 10.0 23:08: +198 0.00049961 10.0 30:42: +199 0.00049768 10.0 26:56: +200 0.00049426 9.9 34:08: +201 0.00048803 9.8 29:49: +202 0.00048564 9.7 01:41: +203 0.00048538 9.7 33:53: +204 0.00048416 9.7 11:49: +205 0.00048398 9.7 32:49: +206 0.00048352 9.7 23:40: +207 0.00047191 9.4 26:57: +208 0.00046198 9.2 23:18: +209 0.00045612 9.1 30:14: +210 0.00045481 9.1 24:56: +211 0.00044608 8.9 34:14: +212 0.00042507 8.5 26:39: +213 0.00041882 8.4 23:14: +214 0.00041719 8.3 30:38: +215 0.00040914 8.2 30:58: 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0.00915 1 52: + 16 0.01445 1 37: + 17 0.01745 1 55: + 18 0.00585 1 56: + 19 0.01595 1 49: + 20 0.01990 1 38: + 21 0.00580 1 45: + 22 0.00885 1 41: + 23 0.01170 1 50: + 24 0.00065 1 42: + 25 0.00260 1 47: + 26 0.00395 1 53: + 27 0.00015 1 46: + 28 0.00055 1 48: + 29 0.00030 1 73: + 30 0.00010 1 54: + 31 0.00010 1 67: + 32 0.00010 1 78: + +Pairwise Linkage Disequilibrium +------------------------------- +--Loci: 0\ 1-- + Haplo Observed* Expected** d_ij d'_ij chisq (*estimated) (**under Ho:no LD) + 02: 39: 145.6010 112.3530 0.0017 0.1228 14.1951 + 02: 51: 401.8756 283.3761 0.0059 0.1736 73.6827 + 02: 40: 595.5854 403.3563 0.0096 0.1978 139.2128 + 02: 44: 1286.4596 863.3291 0.0212 0.2035 344.1084 + 02: 27: 302.6255 251.9877 0.0025 0.0834 15.0464 + 02: 57: 192.1019 213.2655 -0.0011 -0.0992 3.0841 + 02: 15: 656.5366 420.9572 0.0118 0.2323 200.9866 + 02: 18: 231.4192 272.5222 -0.0021 -0.1508 9.2002 + 02: 13: 120.3539 123.7937 -0.0002 -0.0278 0.1382 + 02: 08: 233.2173 640.0897 -0.0203 -0.6356 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13: 0.0000 0.0211 -0.0000 -1.0000 0.0216 + 80: 08: 0.0000 0.1091 -0.0000 -1.0000 0.1225 + 80: 14: 0.0000 0.0359 -0.0000 -1.0000 0.0372 + 80: 35: 0.0000 0.0868 -0.0000 -1.0000 0.0951 + 80: 58: 1.0000 0.0080 0.0000 1.0000 123.2298 + 80: 07: 0.0000 0.1406 -0.0000 -1.0000 0.1636 + 80: 52: 0.0000 0.0092 -0.0000 -1.0000 0.0092 + 80: 37: 0.0000 0.0144 -0.0000 -1.0000 0.0147 + 80: 55: 0.0000 0.0175 -0.0000 -1.0000 0.0178 + 80: 56: 0.0000 0.0059 -0.0000 -1.0000 0.0059 + 80: 49: 0.0000 0.0159 -0.0000 -1.0000 0.0162 + 80: 38: 0.0000 0.0199 -0.0000 -1.0000 0.0203 + 80: 45: 0.0000 0.0058 -0.0000 -1.0000 0.0058 + 80: 41: 0.0000 0.0089 -0.0000 -1.0000 0.0089 + 80: 50: 0.0000 0.0117 -0.0000 -1.0000 0.0118 + 80: 42: 0.0000 0.0006 -0.0000 -1.0000 0.0007 + 80: 47: 0.0000 0.0026 -0.0000 -1.0000 0.0026 + 80: 53: 0.0000 0.0040 -0.0000 -1.0000 0.0040 + 80: 46: 0.0000 0.0001 -0.0000 -1.0000 0.0002 + 80: 48: 0.0000 0.0006 -0.0000 -1.0000 0.0006 + 80: 73: 0.0000 0.0003 -0.0000 -1.0000 0.0003 + 80: 54: 0.0000 0.0001 -0.0000 -1.0000 0.0001 + 80: 67: 0.0000 0.0001 -0.0000 -1.0000 0.0001 + 80: 78: 0.0000 0.0001 -0.0000 -1.0000 0.0001 + +Disequilibrium Summary Measures +------------------------------- +--Loci: 0\ 1-- + Wn [Cohen, 1988]: 0.2713 + Q [Hill, 1975]: 27975.0779 (approx. Chi-square 589) + Dprime [Hedrick, 1987]: 0.3971 + +Asymptotic LR Test for Overall LD [-2*(LL_0 - LL_1)]: 10929.607101, df = 589 diff --git a/src/emhaplofreq/out.NCAU10k_laptop b/src/emhaplofreq/out.NCAU10k_laptop new file mode 100644 index 000000000..2b278d38e --- /dev/null +++ b/src/emhaplofreq/out.NCAU10k_laptop @@ -0,0 +1,1095 @@ +num_loci: 2 +Sample Size (n): 10000 +n_unique_pheno: 4045 +n_unique_geno: 7379 +n_haplo: 448 + +Log likelihood under no LD: -91473.481415 +Log likelihood converged in 67 iterations to : -82313.276038 +Sum of haplotype frequencies = 1.000000 + + Approx No. + MLE Freq* of Copies Haplo (*only printed if MLE > .00001) + 1 0.08130 1626.0 01~08 + 2 0.06432 1286.5 02~44 + 3 0.05791 1158.2 03~07 + 4 0.03899 779.8 02~07 + 5 0.03283 656.5 02~15 + 6 0.02978 595.6 02~40 + 7 0.02528 505.7 29~44 + 8 0.02206 441.1 03~35 + 9 0.02009 401.9 02~51 + 10 0.01739 347.8 01~57 + 11 0.01550 310.0 11~35 + 12 0.01513 302.6 02~27 + 13 0.01453 290.6 24~07 + 14 0.01374 274.8 24~35 + 15 0.01166 233.2 02~08 + 16 0.01157 231.4 02~18 + 17 0.01146 229.1 02~35 + 18 0.00998 199.6 01~07 + 19 0.00980 196.0 25~18 + 20 0.00961 192.1 02~57 + 21 0.00954 190.8 24~15 + 22 0.00891 178.1 03~44 + 23 0.00851 170.1 23~44 + 24 0.00836 167.3 01~37 + 25 0.00834 166.7 26~38 + 26 0.00790 157.9 03~14 + 27 0.00785 157.1 24~44 + 28 0.00784 156.9 31~40 + 29 0.00771 154.2 03~15 + 30 0.00734 146.8 01~35 + 31 0.00728 145.6 02~39 + 32 0.00724 144.7 68~44 + 33 0.00705 141.1 30~13 + 34 0.00677 135.4 03~40 + 35 0.00671 134.2 01~44 + 36 0.00650 130.1 11~07 + 37 0.00636 127.2 33~14 + 38 0.00632 126.4 01~15 + 39 0.00602 120.4 02~50 + 40 0.00602 120.4 02~13 + 41 0.00575 114.9 32~44 + 42 0.00569 113.9 24~40 + 43 0.00531 106.2 11~51 + 44 0.00530 106.1 03~27 + 45 0.00521 104.1 11~44 + 46 0.00506 101.3 24~18 + 47 0.00500 99.9 02~49 + 48 0.00499 99.7 24~51 + 49 0.00489 97.7 32~40 + 50 0.00481 96.1 30~18 + 51 0.00476 95.2 11~55 + 52 0.00468 93.6 03~51 + 53 0.00464 92.8 02~14 + 54 0.00462 92.3 68~14 + 55 0.00447 89.3 03~18 + 56 0.00424 84.7 32~15 + 57 0.00420 84.0 24~27 + 58 0.00411 82.3 68~35 + 59 0.00397 79.4 68~40 + 60 0.00391 78.3 11~40 + 61 0.00382 76.4 24~39 + 62 0.00381 76.2 24~55 + 63 0.00371 74.1 01~18 + 64 0.00358 71.7 32~35 + 65 0.00356 71.2 26~27 + 66 0.00345 69.0 24~08 + 67 0.00339 67.8 11~27 + 68 0.00330 66.0 23~49 + 69 0.00322 64.3 68~51 + 70 0.00310 62.1 03~08 + 71 0.00301 60.3 02~38 + 72 0.00293 58.6 01~51 + 73 0.00291 58.2 01~52 + 74 0.00282 56.3 01~40 + 75 0.00273 54.6 32~14 + 76 0.00271 54.2 32~27 + 77 0.00269 53.8 11~18 + 78 0.00269 53.8 32~07 + 79 0.00260 52.0 31~51 + 80 0.00259 51.9 02~41 + 81 0.00255 51.0 24~57 + 82 0.00253 50.7 26~35 + 83 0.00253 50.6 02~37 + 84 0.00242 48.4 68~15 + 85 0.00239 47.8 24~14 + 86 0.00237 47.4 31~27 + 87 0.00231 46.1 11~52 + 88 0.00230 45.9 68~27 + 89 0.00226 45.2 29~45 + 90 0.00225 45.1 02~55 + 91 0.00224 44.7 31~15 + 92 0.00221 44.2 02~58 + 93 0.00214 42.8 24~38 + 94 0.00205 40.9 02~56 + 95 0.00203 40.6 26~07 + 96 0.00199 39.8 01~27 + 97 0.00199 39.7 01~13 + 98 0.00195 39.0 29~07 + 99 0.00195 38.9 11~15 +100 0.00194 38.8 68~53 +101 0.00187 37.4 24~13 +102 0.00186 37.2 02~52 +103 0.00184 36.8 32~08 +104 0.00183 36.6 26~44 +105 0.00177 35.5 03~13 +106 0.00175 35.0 25~44 +107 0.00174 34.8 66~41 +108 0.00174 34.8 68~07 +109 0.00173 34.5 31~07 +110 0.00173 34.5 31~35 +111 0.00172 34.5 25~08 +112 0.00164 32.9 26~14 +113 0.00160 32.0 32~51 +114 0.00159 31.9 31~44 +115 0.00157 31.5 03~38 +116 0.00157 31.3 24~49 +117 0.00155 31.0 26~51 +118 0.00153 30.7 03~47 +119 0.00146 29.2 02~45 +120 0.00144 28.8 03~57 +121 0.00144 28.8 01~14 +122 0.00142 28.4 26~55 +123 0.00140 28.0 26~15 +124 0.00140 28.0 11~14 +125 0.00140 27.9 01~49 +126 0.00139 27.8 26~40 +127 0.00137 27.5 68~18 +128 0.00137 27.4 01~39 +129 0.00132 26.4 30~35 +130 0.00128 25.6 33~58 +131 0.00124 24.7 25~39 +132 0.00121 24.1 01~38 +133 0.00119 23.8 03~39 +134 0.00116 23.2 11~08 +135 0.00114 22.7 68~08 +136 0.00113 22.7 26~49 +137 0.00113 22.7 30~44 +138 0.00113 22.6 01~58 +139 0.00113 22.5 29~35 +140 0.00112 22.4 03~56 +141 0.00105 21.0 30~08 +142 0.00104 20.9 29~14 +143 0.00104 20.7 32~57 +144 0.00100 20.0 25~07 +145 0.00099 19.8 32~39 +146 0.00098 19.7 26~45 +147 0.00098 19.6 11~56 +148 0.00098 19.6 03~41 +149 0.00097 19.4 03~55 +150 0.00095 18.9 01~55 +151 0.00092 18.4 32~38 +152 0.00091 18.2 11~57 +153 0.00091 18.1 03~50 +154 0.00089 17.8 23~41 +155 0.00088 17.7 30~49 +156 0.00087 17.4 26~37 +157 0.00087 17.3 24~50 +158 0.00083 16.6 32~55 +159 0.00082 16.4 68~39 +160 0.00081 16.1 23~50 +161 0.00080 16.1 31~39 +162 0.00080 16.0 25~58 +163 0.00078 15.7 25~57 +164 0.00077 15.4 29~15 +165 0.00072 14.5 26~18 +166 0.00072 14.4 25~15 +167 0.00072 14.4 31~18 +168 0.00071 14.2 29~27 +169 0.00071 14.2 33~44 +170 0.00070 14.0 69~55 +171 0.00070 14.0 33~35 +172 0.00069 13.8 23~07 +173 0.00067 13.4 30~50 +174 0.00067 13.3 26~08 +175 0.00066 13.2 29~58 +176 0.00066 13.2 32~18 +177 0.00066 13.1 68~38 +178 0.00065 13.0 31~57 +179 0.00064 12.8 03~49 +180 0.00064 12.8 25~40 +181 0.00063 12.6 30~15 +182 0.00062 12.5 01~50 +183 0.00062 12.4 03~37 +184 0.00061 12.1 68~55 +185 0.00060 12.0 24~37 +186 0.00059 11.8 23~15 +187 0.00058 11.6 25~35 +188 0.00057 11.4 23~35 +189 0.00057 11.4 68~57 +190 0.00056 11.1 33~50 +191 0.00055 11.1 11~39 +192 0.00054 10.8 30~41 +193 0.00052 10.5 01~56 +194 0.00052 10.4 26~13 +195 0.00050 10.1 31~08 +196 0.00050 10.0 30~07 +197 0.00050 10.0 23~08 +198 0.00050 10.0 30~42 +199 0.00050 10.0 26~56 +200 0.00049 9.9 34~08 +201 0.00049 9.8 29~49 +202 0.00049 9.7 01~41 +203 0.00049 9.7 33~53 +204 0.00048 9.7 11~49 +205 0.00048 9.7 32~49 +206 0.00048 9.7 23~40 +207 0.00047 9.4 26~57 +208 0.00046 9.2 23~18 +209 0.00046 9.1 30~14 +210 0.00045 9.1 24~56 +211 0.00045 8.9 34~14 +212 0.00043 8.5 26~39 +213 0.00042 8.4 23~14 +214 0.00042 8.3 30~38 +215 0.00041 8.2 30~58 +216 0.00041 8.2 29~08 +217 0.00039 7.9 29~38 +218 0.00039 7.8 31~13 +219 0.00039 7.7 68~13 +220 0.00037 7.3 02~53 +221 0.00037 7.3 11~13 +222 0.00036 7.2 32~13 +223 0.00036 7.1 03~45 +224 0.00036 7.1 30~51 +225 0.00035 7.1 32~50 +226 0.00035 7.0 30~40 +227 0.00035 6.9 29~37 +228 0.00035 6.9 66~35 +229 0.00034 6.9 32~41 +230 0.00034 6.7 23~38 +231 0.00033 6.7 30~27 +232 0.00033 6.6 30~57 +233 0.00033 6.6 23~55 +234 0.00032 6.4 03~58 +235 0.00032 6.3 02~47 +236 0.00032 6.3 68~50 +237 0.00031 6.2 32~52 +238 0.00030 6.1 02~48 +239 0.00030 6.0 31~37 +240 0.00030 6.0 66~52 +241 0.00030 5.9 26~52 +242 0.00029 5.8 29~55 +243 0.00029 5.8 31~55 +244 0.00029 5.8 31~14 +245 0.00028 5.7 68~41 +246 0.00028 5.6 25~27 +247 0.00028 5.6 29~39 +248 0.00027 5.5 29~52 +249 0.00027 5.5 33~27 +250 0.00027 5.4 30~45 +251 0.00027 5.4 29~51 +252 0.00027 5.4 31~38 +253 0.00027 5.3 29~41 +254 0.00026 5.3 24~41 +255 0.00026 5.2 31~58 +256 0.00025 5.1 11~38 +257 0.00025 5.0 29~57 +258 0.00025 5.0 29~50 +259 0.00024 4.9 24~58 +260 0.00024 4.7 33~49 +261 0.00023 4.7 23~51 +262 0.00023 4.7 30~53 +263 0.00023 4.5 31~41 +264 0.00023 4.5 03~52 +265 0.00022 4.4 32~37 +266 0.00022 4.3 11~37 +267 0.00021 4.3 33~18 +268 0.00021 4.2 25~51 +269 0.00020 4.0 01~73 +270 0.00020 4.0 31~49 +271 0.00020 4.0 31~47 +272 0.00020 4.0 24~53 +273 0.00020 4.0 11~53 +274 0.00020 4.0 68~58 +275 0.00020 4.0 01~53 +276 0.00019 3.8 25~37 +277 0.00019 3.8 11~41 +278 0.00019 3.8 29~13 +279 0.00019 3.7 31~52 +280 0.00019 3.7 30~47 +281 0.00018 3.6 68~37 +282 0.00018 3.5 24~52 +283 0.00017 3.5 29~40 +284 0.00017 3.5 33~15 +285 0.00017 3.4 25~38 +286 0.00017 3.4 68~56 +287 0.00017 3.3 01~47 +288 0.00016 3.3 33~07 +289 0.00016 3.3 26~58 +290 0.00016 3.2 69~51 +291 0.00016 3.1 26~50 +292 0.00015 3.0 24~45 +293 0.00015 2.9 66~44 +294 0.00015 2.9 03~53 +295 0.00014 2.8 23~57 +296 0.00014 2.8 68~45 +297 0.00013 2.7 25~55 +298 0.00013 2.7 30~39 +299 0.00013 2.7 29~48 +300 0.00012 2.5 23~13 +301 0.00012 2.4 68~52 +302 0.00012 2.3 33~38 +303 0.00012 2.3 69~39 +304 0.00011 2.3 30~55 +305 0.00011 2.2 74~44 +306 0.00011 2.2 32~58 +307 0.00011 2.2 66~15 +308 0.00011 2.2 23~58 +309 0.00011 2.2 30~52 +310 0.00010 2.1 34~35 +311 0.00010 2.1 33~08 +312 0.00010 2.1 66~38 +313 0.00010 2.0 66~49 +314 0.00010 2.0 01~42 +315 0.00010 2.0 74~27 +316 0.00010 2.0 24~46 +317 0.00010 2.0 23~45 +318 0.00010 2.0 33~57 +319 0.00010 1.9 34~27 +320 0.00010 1.9 34~44 +321 0.00009 1.9 66~18 +322 0.00008 1.7 33~39 +323 0.00008 1.7 23~27 +324 0.00008 1.7 66~14 +325 0.00008 1.7 66~51 +326 0.00008 1.6 29~53 +327 0.00008 1.6 31~48 +328 0.00008 1.6 31~50 +329 0.00008 1.6 01~45 +330 0.00008 1.5 66~07 +331 0.00008 1.5 25~52 +332 0.00007 1.4 69~27 +333 0.00007 1.3 11~58 +334 0.00007 1.3 69~07 +335 0.00006 1.3 25~13 +336 0.00006 1.3 24~54 +337 0.00006 1.2 74~15 +338 0.00006 1.2 36~15 +339 0.00006 1.2 23~56 +340 0.00006 1.1 23~47 +341 0.00006 1.1 11~50 +342 0.00005 1.1 23~53 +343 0.00005 1.0 69~18 +344 0.00005 1.0 68~42 +345 0.00005 1.0 36~27 +346 0.00005 1.0 36~07 +347 0.00005 1.0 74~57 +348 0.00005 1.0 24~67 +349 0.00005 1.0 26~78 +350 0.00005 1.0 34~39 +351 0.00005 1.0 80~58 +352 0.00005 1.0 33~78 +353 0.00005 1.0 25~73 +354 0.00005 1.0 26~67 +355 0.00005 1.0 74~18 +356 0.00005 1.0 32~73 +357 0.00005 1.0 31~46 +358 0.00005 1.0 29~47 +359 0.00004 0.9 26~53 +360 0.00004 0.9 33~40 +361 0.00004 0.9 34~50 +362 0.00004 0.9 25~14 +363 0.00004 0.9 25~47 +364 0.00004 0.8 36~49 +365 0.00004 0.8 74~58 +366 0.00004 0.8 69~57 +367 0.00004 0.8 74~41 +368 0.00004 0.7 11~54 +369 0.00004 0.7 66~47 +370 0.00003 0.6 66~57 +371 0.00003 0.6 24~48 +372 0.00002 0.4 34~51 +373 0.00001 0.3 32~47 + +Allele frequencies +------------------ + Frequency Locus Allele + 1 0.29335 0 02~ + 2 0.02560 0 31~ + 3 0.16360 0 01~ + 4 0.03855 0 68~ + 5 0.05840 0 11~ + 6 0.14260 0 03~ + 7 0.02030 0 25~ + 8 0.01165 0 33~ + 9 0.01885 0 23~ + 10 0.03275 0 26~ + 11 0.09040 0 24~ + 12 0.00135 0 34~ + 13 0.03795 0 29~ + 14 0.03670 0 32~ + 15 0.02280 0 30~ + 16 0.00120 0 69~ + 17 0.00325 0 66~ + 18 0.00045 0 74~ + 19 0.00020 0 36~ + 20 0.00005 0 80~ + 1 0.01915 1 39~ + 2 0.04830 1 51~ + 3 0.06875 1 40~ + 4 0.14715 1 44~ + 5 0.04295 1 27~ + 6 0.03635 1 57~ + 7 0.07175 1 15~ + 8 0.04645 1 18~ + 9 0.02110 1 13~ + 10 0.10910 1 08~ + 11 0.03590 1 14~ + 12 0.08680 1 35~ + 13 0.00805 1 58~ + 14 0.14060 1 07~ + 15 0.00915 1 52~ + 16 0.01445 1 37~ + 17 0.01745 1 55~ + 18 0.00585 1 56~ + 19 0.01595 1 49~ + 20 0.01990 1 38~ + 21 0.00580 1 45~ + 22 0.00885 1 41~ + 23 0.01170 1 50~ + 24 0.00065 1 42~ + 25 0.00260 1 47~ + 26 0.00395 1 53~ + 27 0.00015 1 46~ + 28 0.00055 1 48~ + 29 0.00030 1 73~ + 30 0.00010 1 54~ + 31 0.00010 1 67~ + 32 0.00010 1 78~ + +Pairwise Linkage Disequilibrium +------------------------------- +--Loci: 0\ 1-- + Haplo Observed* Expected** d_ij d'_ij chisq (*estimated) (**under Ho:no LD) + 02~ 39~ 20000.0000 112.3530 0.9944 73.4819 5078962.1590 + 02~ 51~ 0.0000 283.3761 -0.0142 -1.0000 421.3653 + 02~ 40~ 0.0000 403.3563 -0.0202 -1.0000 612.9403 + 02~ 44~ 0.0000 863.3291 -0.0432 -1.0000 1432.5155 + 02~ 27~ 0.0000 251.9877 -0.0126 -1.0000 372.5978 + 02~ 57~ 0.0000 213.2655 -0.0107 -1.0000 313.1820 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6.2066 -0.0003 -1.0000 6.5078 + 68~ 07~ 0.0000 108.4026 -0.0054 -1.0000 131.1951 + 68~ 52~ 0.0000 7.0547 -0.0004 -1.0000 7.4053 + 68~ 37~ 0.0000 11.1410 -0.0006 -1.0000 11.7576 + 68~ 55~ 0.0000 13.4540 -0.0007 -1.0000 14.2419 + 68~ 56~ 0.0000 4.5103 -0.0002 -1.0000 4.7188 + 68~ 49~ 0.0000 12.2974 -0.0006 -1.0000 12.9978 + 68~ 38~ 0.0000 15.3429 -0.0008 -1.0000 16.2821 + 68~ 45~ 0.0000 4.4718 -0.0002 -1.0000 4.6782 + 68~ 41~ 0.0000 6.8234 -0.0003 -1.0000 7.1603 + 68~ 50~ 0.0000 9.0207 -0.0005 -1.0000 9.4935 + 68~ 42~ 0.0000 0.5011 -0.0000 -1.0000 0.5216 + 68~ 47~ 0.0000 2.0046 -0.0001 -1.0000 2.0904 + 68~ 53~ 0.0000 3.0455 -0.0002 -1.0000 3.1801 + 68~ 46~ 0.0000 0.1156 -0.0000 -1.0000 0.1203 + 68~ 48~ 0.0000 0.4241 -0.0000 -1.0000 0.4413 + 68~ 73~ 0.0000 0.2313 -0.0000 -1.0000 0.2406 + 68~ 54~ 0.0000 0.0771 -0.0000 -1.0000 0.0802 + 68~ 67~ 0.0000 0.0771 -0.0000 -1.0000 0.0802 + 68~ 78~ 0.0000 0.0771 -0.0000 -1.0000 0.0802 + 11~ 39~ 0.0000 22.3672 -0.0011 -1.0000 24.2182 + 11~ 51~ 0.0000 56.4144 -0.0028 -1.0000 62.9540 + 11~ 40~ 0.0000 80.3000 -0.0040 -1.0000 91.5762 + 11~ 44~ 0.0000 171.8712 -0.0086 -1.0000 214.0248 + 11~ 27~ 0.0000 50.1656 -0.0025 -1.0000 55.6679 + 11~ 57~ 0.0000 42.4568 -0.0021 -1.0000 46.7909 + 11~ 15~ 0.0000 83.8040 -0.0042 -1.0000 95.8812 + 11~ 18~ 0.0000 54.2536 -0.0027 -1.0000 60.4253 + 11~ 13~ 0.0000 24.6448 -0.0012 -1.0000 26.7375 + 11~ 08~ 0.0000 127.4288 -0.0064 -1.0000 151.9050 + 11~ 14~ 0.0000 41.9312 -0.0021 -1.0000 46.1901 + 11~ 35~ 0.0000 101.3824 -0.0051 -1.0000 117.9045 + 11~ 58~ 0.0000 9.4024 -0.0005 -1.0000 10.0666 + 11~ 07~ 0.0000 164.2208 -0.0082 -1.0000 202.9394 + 11~ 52~ 0.0000 10.6872 -0.0005 -1.0000 11.4549 + 11~ 37~ 0.0000 16.8776 -0.0008 -1.0000 18.1872 + 11~ 55~ 0.0000 20.3816 -0.0010 -1.0000 22.0301 + 11~ 56~ 0.0000 6.8328 -0.0003 -1.0000 7.2993 + 11~ 49~ 0.0000 18.6296 -0.0009 -1.0000 20.1057 + 11~ 38~ 0.0000 23.2432 -0.0012 -1.0000 25.1860 + 11~ 45~ 0.0000 6.7744 -0.0003 -1.0000 7.2365 + 11~ 41~ 0.0000 10.3368 -0.0005 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07~ 0.0000 9.1390 -0.0005 -1.0000 10.6688 + 66~ 52~ 0.0000 0.5948 -0.0000 -1.0000 0.6022 + 66~ 37~ 0.0000 0.9392 -0.0000 -1.0000 0.9561 + 66~ 55~ 0.0000 1.1342 -0.0001 -1.0000 1.1582 + 66~ 56~ 0.0000 0.3803 -0.0000 -1.0000 0.3837 + 66~ 49~ 0.0000 1.0367 -0.0001 -1.0000 1.0570 + 66~ 38~ 0.0000 1.2935 -0.0001 -1.0000 1.3241 + 66~ 45~ 0.0000 0.3770 -0.0000 -1.0000 0.3804 + 66~ 41~ 0.0000 0.5753 -0.0000 -1.0000 0.5823 + 66~ 50~ 0.0000 0.7605 -0.0000 -1.0000 0.7720 + 66~ 42~ 0.0000 0.0422 -0.0000 -1.0000 0.0424 + 66~ 47~ 0.0000 0.1690 -0.0000 -1.0000 0.1700 + 66~ 53~ 0.0000 0.2568 -0.0000 -1.0000 0.2586 + 66~ 46~ 0.0000 0.0097 -0.0000 -1.0000 0.0098 + 66~ 48~ 0.0000 0.0358 -0.0000 -1.0000 0.0359 + 66~ 73~ 0.0000 0.0195 -0.0000 -1.0000 0.0196 + 66~ 54~ 0.0000 0.0065 -0.0000 -1.0000 0.0065 + 66~ 67~ 0.0000 0.0065 -0.0000 -1.0000 0.0065 + 66~ 78~ 0.0000 0.0065 -0.0000 -1.0000 0.0065 + 74~ 39~ 0.0000 0.1724 -0.0000 -1.0000 0.1758 + 74~ 51~ 0.0000 0.4347 -0.0000 -1.0000 0.4570 + 74~ 40~ 0.0000 0.6188 -0.0000 -1.0000 0.6647 + 74~ 44~ 0.0000 1.3243 -0.0001 -1.0000 1.5536 + 74~ 27~ 0.0000 0.3866 -0.0000 -1.0000 0.4041 + 74~ 57~ 0.0000 0.3271 -0.0000 -1.0000 0.3396 + 74~ 15~ 0.0000 0.6457 -0.0000 -1.0000 0.6960 + 74~ 18~ 0.0000 0.4180 -0.0000 -1.0000 0.4386 + 74~ 13~ 0.0000 0.1899 -0.0000 -1.0000 0.1941 + 74~ 08~ 0.0000 0.9819 -0.0000 -1.0000 1.1026 + 74~ 14~ 0.0000 0.3231 -0.0000 -1.0000 0.3353 + 74~ 35~ 0.0000 0.7812 -0.0000 -1.0000 0.8558 + 74~ 58~ 0.0000 0.0725 -0.0000 -1.0000 0.0731 + 74~ 07~ 0.0000 1.2654 -0.0001 -1.0000 1.4731 + 74~ 52~ 0.0000 0.0824 -0.0000 -1.0000 0.0831 + 74~ 37~ 0.0000 0.1300 -0.0000 -1.0000 0.1320 + 74~ 55~ 0.0000 0.1570 -0.0000 -1.0000 0.1599 + 74~ 56~ 0.0000 0.0527 -0.0000 -1.0000 0.0530 + 74~ 49~ 0.0000 0.1435 -0.0000 -1.0000 0.1459 + 74~ 38~ 0.0000 0.1791 -0.0000 -1.0000 0.1828 + 74~ 45~ 0.0000 0.0522 -0.0000 -1.0000 0.0525 + 74~ 41~ 0.0000 0.0796 -0.0000 -1.0000 0.0804 + 74~ 50~ 0.0000 0.1053 -0.0000 -1.0000 0.1066 + 74~ 42~ 0.0000 0.0058 -0.0000 -1.0000 0.0059 + 74~ 47~ 0.0000 0.0234 -0.0000 -1.0000 0.0235 + 74~ 53~ 0.0000 0.0356 -0.0000 -1.0000 0.0357 + 74~ 46~ 0.0000 0.0013 -0.0000 -1.0000 0.0014 + 74~ 48~ 0.0000 0.0050 -0.0000 -1.0000 0.0050 + 74~ 73~ 0.0000 0.0027 -0.0000 -1.0000 0.0027 + 74~ 54~ 0.0000 0.0009 -0.0000 -1.0000 0.0009 + 74~ 67~ 0.0000 0.0009 -0.0000 -1.0000 0.0009 + 74~ 78~ 0.0000 0.0009 -0.0000 -1.0000 0.0009 + 36~ 39~ 0.0000 0.0766 -0.0000 -1.0000 0.0781 + 36~ 51~ 0.0000 0.1932 -0.0000 -1.0000 0.2030 + 36~ 40~ 0.0000 0.2750 -0.0000 -1.0000 0.2954 + 36~ 44~ 0.0000 0.5886 -0.0000 -1.0000 0.6903 + 36~ 27~ 0.0000 0.1718 -0.0000 -1.0000 0.1795 + 36~ 57~ 0.0000 0.1454 -0.0000 -1.0000 0.1509 + 36~ 15~ 0.0000 0.2870 -0.0000 -1.0000 0.3092 + 36~ 18~ 0.0000 0.1858 -0.0000 -1.0000 0.1949 + 36~ 13~ 0.0000 0.0844 -0.0000 -1.0000 0.0862 + 36~ 08~ 0.0000 0.4364 -0.0000 -1.0000 0.4899 + 36~ 14~ 0.0000 0.1436 -0.0000 -1.0000 0.1490 + 36~ 35~ 0.0000 0.3472 -0.0000 -1.0000 0.3803 + 36~ 58~ 0.0000 0.0322 -0.0000 -1.0000 0.0325 + 36~ 07~ 0.0000 0.5624 -0.0000 -1.0000 0.6545 + 36~ 52~ 0.0000 0.0366 -0.0000 -1.0000 0.0369 + 36~ 37~ 0.0000 0.0578 -0.0000 -1.0000 0.0587 + 36~ 55~ 0.0000 0.0698 -0.0000 -1.0000 0.0711 + 36~ 56~ 0.0000 0.0234 -0.0000 -1.0000 0.0235 + 36~ 49~ 0.0000 0.0638 -0.0000 -1.0000 0.0648 + 36~ 38~ 0.0000 0.0796 -0.0000 -1.0000 0.0812 + 36~ 45~ 0.0000 0.0232 -0.0000 -1.0000 0.0233 + 36~ 41~ 0.0000 0.0354 -0.0000 -1.0000 0.0357 + 36~ 50~ 0.0000 0.0468 -0.0000 -1.0000 0.0474 + 36~ 42~ 0.0000 0.0026 -0.0000 -1.0000 0.0026 + 36~ 47~ 0.0000 0.0104 -0.0000 -1.0000 0.0104 + 36~ 53~ 0.0000 0.0158 -0.0000 -1.0000 0.0159 + 36~ 46~ 0.0000 0.0006 -0.0000 -1.0000 0.0006 + 36~ 48~ 0.0000 0.0022 -0.0000 -1.0000 0.0022 + 36~ 73~ 0.0000 0.0012 -0.0000 -1.0000 0.0012 + 36~ 54~ 0.0000 0.0004 -0.0000 -1.0000 0.0004 + 36~ 67~ 0.0000 0.0004 -0.0000 -1.0000 0.0004 + 36~ 78~ 0.0000 0.0004 -0.0000 -1.0000 0.0004 + 80~ 39~ 0.0000 0.0192 -0.0000 -1.0000 0.0195 + 80~ 51~ 0.0000 0.0483 -0.0000 -1.0000 0.0508 + 80~ 40~ 0.0000 0.0688 -0.0000 -1.0000 0.0738 + 80~ 44~ 0.0000 0.1472 -0.0000 -1.0000 0.1725 + 80~ 27~ 0.0000 0.0430 -0.0000 -1.0000 0.0449 + 80~ 57~ 0.0000 0.0364 -0.0000 -1.0000 0.0377 + 80~ 15~ 0.0000 0.0717 -0.0000 -1.0000 0.0773 + 80~ 18~ 0.0000 0.0464 -0.0000 -1.0000 0.0487 + 80~ 13~ 0.0000 0.0211 -0.0000 -1.0000 0.0216 + 80~ 08~ 0.0000 0.1091 -0.0000 -1.0000 0.1225 + 80~ 14~ 0.0000 0.0359 -0.0000 -1.0000 0.0372 + 80~ 35~ 0.0000 0.0868 -0.0000 -1.0000 0.0951 + 80~ 58~ 0.0000 0.0080 -0.0000 -1.0000 0.0081 + 80~ 07~ 0.0000 0.1406 -0.0000 -1.0000 0.1636 + 80~ 52~ 0.0000 0.0092 -0.0000 -1.0000 0.0092 + 80~ 37~ 0.0000 0.0144 -0.0000 -1.0000 0.0147 + 80~ 55~ 0.0000 0.0175 -0.0000 -1.0000 0.0178 + 80~ 56~ 0.0000 0.0059 -0.0000 -1.0000 0.0059 + 80~ 49~ 0.0000 0.0159 -0.0000 -1.0000 0.0162 + 80~ 38~ 0.0000 0.0199 -0.0000 -1.0000 0.0203 + 80~ 45~ 0.0000 0.0058 -0.0000 -1.0000 0.0058 + 80~ 41~ 0.0000 0.0089 -0.0000 -1.0000 0.0089 + 80~ 50~ 0.0000 0.0117 -0.0000 -1.0000 0.0118 + 80~ 42~ 0.0000 0.0006 -0.0000 -1.0000 0.0007 + 80~ 47~ 0.0000 0.0026 -0.0000 -1.0000 0.0026 + 80~ 53~ 0.0000 0.0040 -0.0000 -1.0000 0.0040 + 80~ 46~ 0.0000 0.0001 -0.0000 -1.0000 0.0002 + 80~ 48~ 0.0000 0.0006 -0.0000 -1.0000 0.0006 + 80~ 73~ 0.0000 0.0003 -0.0000 -1.0000 0.0003 + 80~ 54~ 0.0000 0.0001 -0.0000 -1.0000 0.0001 + 80~ 67~ 0.0000 0.0001 -0.0000 -1.0000 0.0001 + 80~ 78~ 0.0000 0.0001 -0.0000 -1.0000 0.0001 + +Disequilibrium Summary Measures +------------------------------- +--Loci: 0\ 1-- + Wn [Cohen, 1988]: 3.0523 + Q [Hill, 1975]: 3540205.9757 (approx. Chi-square 589) + Dprime [Hedrick, 1987]: 1.4072 + +Asymptotic LR Test for Overall LD [-2*(LL_0 - LL_1)]: 18320.410754, df = 589