diff --git a/bindings/python/Cargo.toml b/bindings/python/Cargo.toml
index 28f5725767d9..0ecb72511eed 100644
--- a/bindings/python/Cargo.toml
+++ b/bindings/python/Cargo.toml
@@ -161,8 +161,8 @@ futures = "0.3.28"
 opendal = { version = ">=0", path = "../../core", features = [
   "layers-blocking",
 ] }
-pyo3 = { version = "0.21.2", features = ["abi3", "abi3-py311"] }
-pyo3-asyncio = { package = "pyo3-asyncio-0-21", version = "0.21", features = [
+pyo3 = { version = "0.22.5", features = ["abi3", "abi3-py311"] }
+pyo3-async-runtimes = { version = "0.22.0", features = [
   "tokio-runtime",
 ] }
 tokio = "1"
diff --git a/bindings/python/pyproject.toml b/bindings/python/pyproject.toml
index cb64f80e69d1..fd58e48ff34a 100644
--- a/bindings/python/pyproject.toml
+++ b/bindings/python/pyproject.toml
@@ -29,9 +29,7 @@ description = "Apache OpenDAL™ Python Binding"
 license = { text = "Apache-2.0" }
 name = "opendal"
 readme = "README.md"
-# PyO3 doesn't support python 3.13 yet.
-# ref: https://github.com/apache/opendal/issues/4268
-requires-python = ">=3.11, < 3.13"
+requires-python = ">=3.11"
 
 [project.optional-dependencies]
 benchmark = [
diff --git a/bindings/python/src/file.rs b/bindings/python/src/file.rs
index 53a65a274f9e..be7a461893e3 100644
--- a/bindings/python/src/file.rs
+++ b/bindings/python/src/file.rs
@@ -31,7 +31,7 @@ use pyo3::buffer::PyBuffer;
 use pyo3::exceptions::PyIOError;
 use pyo3::exceptions::PyValueError;
 use pyo3::prelude::*;
-use pyo3_asyncio::tokio::future_into_py;
+use pyo3_async_runtimes::tokio::future_into_py;
 use tokio::sync::Mutex;
 
 use crate::*;
diff --git a/bindings/python/src/lister.rs b/bindings/python/src/lister.rs
index e108ec2dcc36..e2074016fae3 100644
--- a/bindings/python/src/lister.rs
+++ b/bindings/python/src/lister.rs
@@ -20,7 +20,7 @@ use std::sync::Arc;
 use futures::TryStreamExt;
 use pyo3::exceptions::PyStopAsyncIteration;
 use pyo3::prelude::*;
-use pyo3_asyncio::tokio::future_into_py;
+use pyo3_async_runtimes::tokio::future_into_py;
 use tokio::sync::Mutex;
 
 use crate::*;
diff --git a/bindings/python/src/operator.rs b/bindings/python/src/operator.rs
index 54e7345741fe..0e6c51ce1071 100644
--- a/bindings/python/src/operator.rs
+++ b/bindings/python/src/operator.rs
@@ -22,7 +22,7 @@ use std::time::Duration;
 use pyo3::prelude::*;
 use pyo3::types::PyBytes;
 use pyo3::types::PyDict;
-use pyo3_asyncio::tokio::future_into_py;
+use pyo3_async_runtimes::tokio::future_into_py;
 
 use crate::*;
 
@@ -32,7 +32,7 @@ fn build_operator(
 ) -> PyResult<ocore::Operator> {
     let mut op = ocore::Operator::via_iter(scheme, map).map_err(format_pyerr)?;
     if !op.info().full_capability().blocking {
-        let runtime = pyo3_asyncio::tokio::get_runtime();
+        let runtime = pyo3_async_runtimes::tokio::get_runtime();
         let _guard = runtime.enter();
         op = op
             .layer(ocore::layers::BlockingLayer::create().expect("blocking layer must be created"));