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DESCRIPTION
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DESCRIPTION
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Package: ncar
Type: Package
Title: Noncompartmental Analysis of Pharmacokinetic Data for CDISC Standardized Parameters
Version: 0.3.1
Author: Kyun-Seop Bae [aut, cre], Sungpil Han [aut]
Maintainer: Sungpil Han <[email protected]>
Description: Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' <https://www.certara.com/software/pkpd-modeling-and-simulation/phoenix-winnonlin/>.
Some features include:
1) Use CDISC SDTM PP domain terms and generate PP domains from DM, EX, and PC domains.
2) Automatic slope selection with the same criterion of WinNonlin(R)
3) Support both 'linear-up linear-down' and 'linear-up log-down' method
4) Calculate partial(interval) AUC with 'linear' or 'log' interpolation method
5) Perform a noncompartmental analysis of CDISC standardized pharmacokinetic dataset (.XPT)
For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107)
*) Acknowledgement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.
License: GPL-3 | file LICENSE
LazyLoad: true
LazyData: true
Copyright: 2017, Kyun-Seop Bae, Sungpil Han
Depends: R (>= 2.10)
Imports: dplyr, tidyr, Hmisc, lubridate, measurements
NeedsCompilation: no
URL: https://github.com/asancpt/ncar
BugReports: https://github.com/asancpt/ncar/issues
RoxygenNote: 5.0.1