diff --git a/content/pipeline/img/status/coronaviridae_paused.png b/content/pipeline/img/status/coronaviridae_paused.png
new file mode 100644
index 000000000..e592eb357
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diff --git a/content/pipeline/img/status/coronaviridae_play.png b/content/pipeline/img/status/coronaviridae_play.png
new file mode 100644
index 000000000..f269bd384
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diff --git a/content/pipeline/img/status/flaviviridae_paused.png b/content/pipeline/img/status/flaviviridae_paused.png
new file mode 100644
index 000000000..872919875
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diff --git a/content/pipeline/img/status/flaviviridae_play.png b/content/pipeline/img/status/flaviviridae_play.png
new file mode 100644
index 000000000..f948aca74
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diff --git a/content/pipeline/img/status/picornaviridae_paused.png b/content/pipeline/img/status/picornaviridae_paused.png
new file mode 100644
index 000000000..a7e06d9fb
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diff --git a/content/pipeline/img/status/picornaviridae_play.png b/content/pipeline/img/status/picornaviridae_play.png
new file mode 100644
index 000000000..4a9b2bbb6
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diff --git a/content/pipeline/img/status/togaviridae_paused.png b/content/pipeline/img/status/togaviridae_paused.png
new file mode 100644
index 000000000..e7ecbecf6
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diff --git a/content/pipeline/img/status/togaviridae_play.png b/content/pipeline/img/status/togaviridae_play.png
new file mode 100644
index 000000000..18f220a72
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diff --git a/content/pipeline/img/targets/enterovirus-VP1-capsid.png b/content/pipeline/img/targets/enterovirus-VP1-capsid.png
new file mode 100644
index 000000000..32b5af49b
Binary files /dev/null and b/content/pipeline/img/targets/enterovirus-VP1-capsid.png differ
diff --git a/data/outputs/TCPs.yaml b/data/outputs/TCPs.yaml
index f041ddf93..ae2825f62 100644
--- a/data/outputs/TCPs.yaml
+++ b/data/outputs/TCPs.yaml
@@ -1,6 +1,6 @@
ASAP-COV-MPRO:
permalink: http://asapdiscovery.org/outputs/target-candidate-profiles/#ASAP-TCP-COV-MPRO
- name: MERS-CoV and SARS-CoV-2 Oral MPro protease inhibitor
+ name: MERS-CoV / SARS-CoV-2 MPro protease oral inhibitor
type: Target Candidate Profile
status: completed
projects: [Project 5]
@@ -27,7 +27,7 @@ MOONSHOT-COV-MPRO:
ASAP-SARS-COV-2-NSP3-MAC1:
permalink: http://asapdiscovery.org/outputs/target-candidate-profiles/#ASAP-TCP-SARS-COV-2-NSP3-MAC1
- name: SARS-CoV-2 Oral nsp3 Mac1 macrodomain inhibitor
+ name: SARS-CoV-2 nsp3 Mac1 macrodomain oral inhibitor
type: Target Candidate Profile
projects: [Project 3, Project 5]
status: completed
@@ -40,7 +40,7 @@ ASAP-SARS-COV-2-NSP3-MAC1:
ASAP-EVD68-3CLPRO:
permalink: http://asapdiscovery.org/outputs/target-candidate-profiles/#ASAP-EVD68-3CLPRO
- name: EV-D68/A71 Oral 3C protease inhibitor
+ name: EV-D68/A71 3C protease oral inhibitor
type: Target Candidate Profile
projects: [Project 3, Project 5]
status: completed
@@ -48,17 +48,32 @@ ASAP-EVD68-3CLPRO:
- name: Lead Transition Profile
url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g2881a7b0765_4_0
- name: Target Candidate Profile
- url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g285bac68500_0_165
+ url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g285bac68500_0_427
events:
- date: 2023-06-22
description: Initial drafts
+ASAP-EVD68-EVA71-VP1-CAPSID:
+ permalink: http://asapdiscovery.org/outputs/target-candidate-profiles/#ASAP-EVD68-EVA71-VP1-CAPSID
+ name: EV-D68/A71 VP1 capsid assembly oral inhibitor
+ type: Target Candidate Profile
+ projects: [Project 3, Project 5]
+ status: completed
+ links:
+ - name: Lead Transition Profile
+ url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g2a71abbb706_0_10
+ - name: Target Candidate Profile
+ url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g2a71abbb706_0_0
+ events:
+ - date: 2023-12-15
+ description: Initial drafts
+
ASAP-ZIKA-NS2B-NS3:
permalink: http://asapdiscovery.org/outputs/target-candidate-profiles/#ASAP-ZIKA-NS2B-NS3
- name: Target Candidate Profile Dengue & Zika NS2B-NS3 Protease Oral Community
+ name: DENV/ZIKV NS2B/3 protease oral inhibitor
type: Target Candidate Profile
projects: [Project 3, Project 5]
- status: completed
+ status: draft
links:
- name: Target Candidate Profile
url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g285bac68500_0_340
diff --git a/data/outputs/TPPs.yaml b/data/outputs/TPPs.yaml
index 6df8afc98..2ac34658c 100644
--- a/data/outputs/TPPs.yaml
+++ b/data/outputs/TPPs.yaml
@@ -44,12 +44,12 @@ ASAP-TPP-EVD68-PEDIATRIC:
projects: [Project 6, Project 5]
links:
- name: Target Product Profile
- url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g217bd676945_0_0
+ url: https://docs.google.com/presentation/d/1uZht18ZJnHuwMtwxY4prDBSl4SFMK-ics4ERhDgiJ2s/edit#slide=id.g285bac68500_0_417
events:
- date: 2023-03-08
description: Initial draft
- date: 2023-06-22
- description: EV-D68 and EV-A71 combined TPP
+ description: Combined TPPs for EV-D68 and EV-A71
ASAP-TPP-ZIKA:
permalink: http://asapdiscovery.org/outputs/target-product-profile/#ASAP-TPP-ZIKA
diff --git a/data/programs/ASAP-COV-MPRO.yaml b/data/programs/ASAP-COV-MPRO.yaml
index d6cfc940a..79e58a3d4 100644
--- a/data/programs/ASAP-COV-MPRO.yaml
+++ b/data/programs/ASAP-COV-MPRO.yaml
@@ -1,7 +1,7 @@
overview:
# viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
family: coronaviridae
- name: "SARS-CoV-2 / MERS-CoV Mpro protease"
+ name: "MERS-CoV/SARS-CoV-2 Mpro protease"
target: Mpro
program_code: ASAPPTGTTM
program_nickname: ASAP-COV-MPRO
@@ -51,9 +51,6 @@ lead_optimization:
molecules:
status: in-progress
-publications:
- status: in-progress
-
diff --git a/data/programs/ASAP-DENV-NS2B-NS3.yaml b/data/programs/ASAP-DENV-NS2B-NS3.yaml
index 2f4c4d043..85d2156b7 100644
--- a/data/programs/ASAP-DENV-NS2B-NS3.yaml
+++ b/data/programs/ASAP-DENV-NS2B-NS3.yaml
@@ -1,12 +1,16 @@
overview:
# viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
family: flaviviridae
- name: "Dengue NS2B-NS3 protease"
+ name: "DENV/ZIKV NS2B/3 protease"
target: NS2B-NS3
- program_code: ASAPPOWITW
- program_nickname: ASAP-DENV-NS2B-NS3
+ program_code: ASAPPADTOT
+ program_nickname: ASAP-DENV-ZIKA-NS2B-NS3
viruses:
- - Dengue serotype 2
+ - DENV-1
+ - DENV-2
+ - DENV-3
+ - DENV-4
+ - ZIKV
img: "DENV-ns2b-ns3.png"
funding_source:
@@ -18,6 +22,10 @@ funding_source:
targeting_opportunity:
status: completed
+# TODO: Share the Fitness Viewer and DMS data
+circulating_variants:
+ status: completed
+
TPP:
status: completed
id: ASAP-TPP-DENV
@@ -26,6 +34,13 @@ TEP:
# TODO: Can we pull the status rom the TEP itself?
status: in-progress
+TCP:
+ status: completed
+ id: ASAP-ZIKA-NS2B-NS3
+
+hit_to_lead:
+ status: play
+
assay_cascade:
status: in-progress
#url: https://covid.postera.ai/covid/activity_data
diff --git a/data/programs/ASAP-DENV-NS3-PROTEASE-HELICASE.yaml b/data/programs/ASAP-DENV-NS3-PROTEASE-HELICASE.yaml
deleted file mode 100644
index db722d957..000000000
--- a/data/programs/ASAP-DENV-NS3-PROTEASE-HELICASE.yaml
+++ /dev/null
@@ -1,28 +0,0 @@
-overview:
- # viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
- family: flaviviridae
- name: "Dengue NS2B-NS3 protease-helicase"
- target: NS2B-NS3
- program_code: ASAPPOHAJC
- program_nickname: ASAP-DENV-NS3-PROTEASE-HELICASE
- viruses:
- - Dengue serotype 2
- img: "DENV-ns2b-ns3.png"
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
- url: https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865
-
-targeting_opportunity:
- status: completed
-
-TPP:
- status: completed
- id: ASAP-TPP-DENV
-
-TEP:
- # TODO: Can we pull the status rom the TEP itself?
- status: not-started
-
diff --git a/data/programs/ASAP-EVD68-2APRO.yaml b/data/programs/ASAP-EVD68-2APRO.yaml
index a6a423864..b363070b5 100644
--- a/data/programs/ASAP-EVD68-2APRO.yaml
+++ b/data/programs/ASAP-EVD68-2APRO.yaml
@@ -25,5 +25,6 @@ TPP:
id: ASAP-TPP-EVD68-PEDIATRIC
TEP:
- status: not-started
+ status: play
+ id: ASAP-TEP-EVA71-2APRO
diff --git a/data/programs/ASAP-EVD68-3CLPRO.yaml b/data/programs/ASAP-EVD68-3CLPRO.yaml
index bd07aec0f..7eb4f1997 100644
--- a/data/programs/ASAP-EVD68-3CLPRO.yaml
+++ b/data/programs/ASAP-EVD68-3CLPRO.yaml
@@ -24,7 +24,7 @@ TPP:
id: ASAP-TPP-EVD68-PEDIATRIC
TEP:
- status: completed
+ status: not-started
TCP:
status: completed
@@ -35,7 +35,7 @@ assay_cascade:
id: ASAP-ASSAY-EVD68-3CLPRO
hit_to_lead:
- status: in-progress
+ status: play
molecules:
status: in-progress
diff --git a/data/programs/ASAP-SARS-COV-2-ENDORIBONUCLEASE.yaml b/data/programs/ASAP-SARS-COV-2-ENDORIBONUCLEASE.yaml
index 9246a8626..8b8ce15ff 100644
--- a/data/programs/ASAP-SARS-COV-2-ENDORIBONUCLEASE.yaml
+++ b/data/programs/ASAP-SARS-COV-2-ENDORIBONUCLEASE.yaml
@@ -27,7 +27,7 @@ TPP:
TEP:
# TODO: Can we pull the status rom the TEP itself?
- status: in-progress
+ status: play
publications:
status: in-progress
diff --git a/data/programs/ASAP-WNV-NS2B-NS3.yaml b/data/programs/ASAP-WNV-NS2B-NS3.yaml
deleted file mode 100644
index 5460f3501..000000000
--- a/data/programs/ASAP-WNV-NS2B-NS3.yaml
+++ /dev/null
@@ -1,32 +0,0 @@
-overview:
- # viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
- family: flaviviridae
- name: "West Nile NS2B-NS3 protease"
- target: NS2B-NS3
- program_code: ASAPPNTTOW
- program_nickname: ASAP-WNV-NS2B-NS3
- viruses:
- - West Nile
- img: "DENV-ns2b-ns3.png"
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
- url: https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865
-
-targeting_opportunity:
- status: completed
-
-TEP:
- # TODO: Can we pull the status rom the TEP itself?
- status: in-progress
-
-assay_cascade:
- status: in-progress
-
-covalent_targeting:
- status: in-progress
-
-molecules:
- status: in-progress
diff --git a/data/programs/ASAP-WNV-NS3-PROTEASE-HELICASE.yaml b/data/programs/ASAP-WNV-NS3-PROTEASE-HELICASE.yaml
deleted file mode 100644
index 0f1627196..000000000
--- a/data/programs/ASAP-WNV-NS3-PROTEASE-HELICASE.yaml
+++ /dev/null
@@ -1,23 +0,0 @@
-overview:
- # viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
- family: flaviviridae
- name: "West Nile NS2B-NS3 protease-helicase"
- target: NS2B-NS3
- program_code: ASAPPTSBOE
- program_nickname: ASAP-WNV-NS3-PROTEASE-HELICASE
- viruses:
- - West Nile
- img: "DENV-ns2b-ns3.png"
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
- url: https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865
-
-targeting_opportunity:
- status: completed
-
-TEP:
- # TODO: Can we pull the status rom the TEP itself?
- status: not-started
diff --git a/data/programs/ASAP-ZIKA-NS2B-NS3.yaml b/data/programs/ASAP-ZIKA-NS2B-NS3.yaml
deleted file mode 100644
index 5c481d619..000000000
--- a/data/programs/ASAP-ZIKA-NS2B-NS3.yaml
+++ /dev/null
@@ -1,50 +0,0 @@
-overview:
- # viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
- family: flaviviridae
- name: "Zika NS2B-NS3 protease"
- target: NS2B-NS3
- program_code: ASAPPADTOT
- program_nickname: ASAP-ZIKA-NS2B-NS3
- viruses:
- - Zika
- img: "DENV-ns2b-ns3.png"
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
- url: https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
-
-targeting_opportunity:
- status: completed
-
-TPP:
- status: completed
- id: ASAP-TPP-ZIKA
-
-TCP:
- status: completed
- id: ASAP-ZIKA-NS2B-NS3
-
-TEP:
- status: completed
-
-assay_cascade:
- status: in-progress
-
-covalent_targeting:
- status: in-progress
-
-hit_to_lead:
- status: in-progress
-
-molecules:
- status: in-progress
-
-publications:
- status: in-progress
diff --git a/data/programs/ASAP-ZIKA-NS3-HELICASE.yaml b/data/programs/ASAP-ZIKA-NS3-HELICASE.yaml
index 147ffd903..605d5f95d 100644
--- a/data/programs/ASAP-ZIKA-NS3-HELICASE.yaml
+++ b/data/programs/ASAP-ZIKA-NS3-HELICASE.yaml
@@ -1,13 +1,19 @@
overview:
# viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
family: flaviviridae
- name: "Zika NS3 helicase"
+ name: "DENV/ZIKV/WNV NS3 helicase"
target: helicase
program_code: ASAPPWDRPT
program_nickname: ASAP-ZIKA-NS3-HELICASE
viruses:
- - Zika
- img: "zika_ns5b.png"
+ - DENV-1
+ - DENV-2
+ - DENV-3
+ - DENV-4
+ - ZIKV
+ - WNV
+
+ img: "DENV-ns2b-ns3.png"
funding_source:
funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
@@ -24,6 +30,6 @@ TPP:
TEP:
# TODO: Can we pull the status rom the TEP itself?
- status: in-progress
+ status: play
diff --git a/data/programs/ASAP-ZIKA-NS3-PROTEASE-HELICASE.yaml b/data/programs/ASAP-ZIKA-NS3-PROTEASE-HELICASE.yaml
deleted file mode 100644
index af0d95c7d..000000000
--- a/data/programs/ASAP-ZIKA-NS3-PROTEASE-HELICASE.yaml
+++ /dev/null
@@ -1,27 +0,0 @@
-overview:
- # viral family: one of ['coronaviridae', 'flaviviridae', 'picornaviridae', 'togaviridae']
- family: flaviviridae
- name: "Zika NS2B-NS3 protease-helicase"
- target: NS2B-NS3
- program_code: ASAPPPOEAD
- program_nickname: ASAP-ZIKA-NS3-PROTEASE-HELICASE
- viruses:
- - Zika
- img: "DENV-ns2b-ns3.png"
-
-funding_source:
- funder: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH)
- grant: U19AI171399
- img: niaid-logo.png
- url: https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865
-
-targeting_opportunity:
- status: completed
-
-TPP:
- status: completed
- id: ASAP-TPP-ZIKA
-
-TEP:
- # TODO: Can we pull the status rom the TEP itself?
- status: not-started
diff --git a/themes/kube/layouts/section/pipeline.html b/themes/kube/layouts/section/pipeline.html
index 26614cdc0..b6d36bc13 100644
--- a/themes/kube/layouts/section/pipeline.html
+++ b/themes/kube/layouts/section/pipeline.html
@@ -100,7 +100,7 @@ Discovery Program
- 
+ 
