diff --git a/CHANGES.rst b/CHANGES.rst
index aedf7ec14f..fbb075d01d 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -189,7 +189,7 @@ Infrastructure, Utility and Other Changes and Additions
 
 - Removed deprecated function ``utils.download_list_of_fitsfiles()``. [#2594]
 
-- Versions of astropy <4.1 are no longer supported. [#2602]
+- Versions of astropy <4.2.1 and numpy <1.18 are no longer supported. [#2602]
 
 
 
diff --git a/README.rst b/README.rst
index f698da6b20..2f51ed3481 100644
--- a/README.rst
+++ b/README.rst
@@ -43,7 +43,7 @@ Installation and Requirements
 -----------------------------
 
 Astroquery works with Python 3.7 or later.
-As an `astropy`_ affiliate, astroquery requires `astropy`_ version 4.1 or later.
+As an `astropy`_ affiliate, astroquery requires `astropy`_ version 4.2.1 or later.
 
 astroquery uses the `requests <https://requests.readthedocs.io/en/latest/>`_
 module to communicate with the internet.  `BeautifulSoup
diff --git a/docs/index.rst b/docs/index.rst
index ba49d6ea0d..3b81f706ce 100644
--- a/docs/index.rst
+++ b/docs/index.rst
@@ -84,8 +84,8 @@ Astroquery works with Python 3.7 or later.
 
 The following packages are required for astroquery installation & use:
 
-* `numpy <http://www.numpy.org>`_ >= 1.16
-* `astropy <http://www.astropy.org>`__ (>=4.1)
+* `numpy <http://www.numpy.org>`_ >= 1.18
+* `astropy <http://www.astropy.org>`__ (>=4.2.1)
 * `pyVO`_ (>=1.1)
 * `requests <https://requests.readthedocs.io/en/latest/>`_
 * `keyring <https://pypi.python.org/pypi/keyring>`_
diff --git a/setup.cfg b/setup.cfg
index 85eeb280e6..fff76ae20f 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -159,8 +159,8 @@ omit =
 python_requires = >=3.7
 
 install_requires=
-   numpy>=1.16
-   astropy>=4.1
+   numpy>=1.18
+   astropy>=4.2.1
    requests>=2.4.3
    beautifulsoup4>=4.3.2
    html5lib>=0.999
diff --git a/tox.ini b/tox.ini
index 5ba80d78dc..8f11d5cd05 100644
--- a/tox.ini
+++ b/tox.ini
@@ -31,8 +31,8 @@ deps =
 
 # mpl while not a dependency, it's required for the tests, and would pull up a newer numpy version if not pinned.
 
-    oldestdeps: astropy==4.1
-    oldestdeps: numpy==1.16
+    oldestdeps: astropy==4.2.1
+    oldestdeps: numpy==1.18
     oldestdeps: matplotlib==3.3.*
     oldestdeps: pyvo==1.1
     cov: codecov