diff --git a/libvirt/tests/cfg/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.cfg b/libvirt/tests/cfg/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.cfg
new file mode 100644
index 0000000000..0ce7b99310
--- /dev/null
+++ b/libvirt/tests/cfg/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.cfg
@@ -0,0 +1,25 @@
+- guest_numa_node_tuning.invalid_nodeset:
+    type = invalid_nodeset_of_numa_memory_binding
+    start_vm = "no"
+    error_msg = "error: unsupported configuration: NUMA node 2 is unavailable"
+    variants tuning:
+        - strict:
+            tuning_mode = "strict"
+        - interleave:
+            tuning_mode = "interleave"
+        - preferred:
+            tuning_mode = "preferred"
+        - restrictive:
+            tuning_mode = "restrictive"
+    variants node_set:
+        - partially_inexistent:
+            nodeset = "1-2"
+        - totally_inexistent:
+            nodeset = "2-3"
+    variants binding:
+        - host:
+            vm_attrs = {'numa_memory': {'mode': "${tuning_mode}",'nodeset': "${nodeset}"}}
+        - guest:
+            cell_id = 0
+            numa_attr = "'cpu': {'numa_cell': [{'id': ${cell_id}, 'cpus': '0-1', 'memory': '2097152', 'unit': 'KiB'}]}"
+            vm_attrs = {${numa_attr},'numa_memnode': [{'cellid':"${cell_id}",'mode': "${tuning_mode}",'nodeset':"${nodeset}"}]}
diff --git a/libvirt/tests/src/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.py b/libvirt/tests/src/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.py
new file mode 100644
index 0000000000..b4afb61e55
--- /dev/null
+++ b/libvirt/tests/src/numa/numa_node_tuning/invalid_nodeset_of_numa_memory_binding.py
@@ -0,0 +1,70 @@
+# ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
+#
+#   Copyright Redhat
+#
+#   SPDX-License-Identifier: GPL-2.0
+
+#   Author: Nan Li <nanli@redhat.com>
+#
+# ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
+import re
+
+from virttest import virt_vm
+
+from virttest.libvirt_xml import vm_xml
+
+
+def run(test, params, env):
+    """
+    Verify that error msg prompts when starting a guest vm with
+    invalid nodeset of numa memory binding
+    """
+
+    def setup_test():
+        """
+        Prepare init xml
+        """
+        test.log.info("TEST_SETUP: Set hugepage and guest boot ")
+        vmxml = vm_xml.VMXML.new_from_dumpxml(vm_name)
+        vmxml.setup_attrs(**vm_attrs)
+        vmxml.sync()
+
+        vmxml = vm_xml.VMXML.new_from_dumpxml(vm_name)
+        test.log.debug("The init xml is:\n%s", vmxml)
+
+    def run_test():
+        """
+        Start vm and check result
+        """
+        test.log.info("TEST_STEP1: Start vm and check result")
+        try:
+            vm.start()
+            if vm.is_alive():
+                test.fail("Guest state should not be running")
+        except virt_vm.VMStartError as detail:
+            if not re.search(error_msg, str(detail)):
+                test.fail("Expect '%s' in '%s' " % (error_msg, str(detail)))
+            else:
+                test.log.debug("Got '%s' in '%s'" % (error_msg, detail))
+
+    def teardown_test():
+        """
+        Clean data.
+        """
+        test.log.info("TEST_TEARDOWN: Clean up env.")
+        bkxml.sync()
+
+    vm_name = params.get("main_vm")
+    vm = env.get_vm(vm_name)
+    vmxml = vm_xml.VMXML.new_from_inactive_dumpxml(vm_name)
+    bkxml = vmxml.copy()
+
+    vm_attrs = eval(params.get("vm_attrs"))
+    error_msg = params.get("error_msg")
+
+    try:
+        setup_test()
+        run_test()
+
+    finally:
+        teardown_test()