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DESCRIPTION
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DESCRIPTION
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Package: impulse
Title: Fit Impulse and Sigmoidal Curves to Longitudinal Data Using TensorFlow
Version: 1.1.2
Authors@R: person(given = "Sean", family = "Hackett",
role = c("aut", "cre"),
email = "[email protected]",
comment = c(ORCID = "0000-0002-9553-4341"))
Author: Sean Hackett [aut, cre]
Maintainer: Sean Hackett <[email protected]>
Description: Implements the phenomenological kinetic model of Chechik and Koller <doi:10.1089/cmb.2008.13TT> using
Bayesian priors to improve interpretability. Two models can be fit: a sigmoidal model parameterized
by a half-max time constant, an asymptote and a rate constant, as well as an impulse model which adds
a second sigmoidal response described by a second time constant and asymptote. Priors enforce
non-negativity of timing and rate coefficients and with appropriate tuning, focus support on plausible
parameter ranges. TensorFlow is used to optimize the maximum posterior estimate (MAP) as a combination
of a non-linear least squares likelihood and priors on kinetic coefficients.
License: MIT + file LICENSE
SystemRequirements: Python (>= 2.7), Conda
Encoding: UTF-8
LazyData: true
Depends:
R (>= 3.1)
Imports:
checkmate,
dplyr,
ggplot2,
glue,
purrr,
reticulate,
rlang,
tensorflow (>= 1.9),
tibble,
tidyr (>= 1.0)
Suggests:
gridExtra,
knitr,
rcmdcheck,
rmarkdown,
testthat (>= 3.0.0)
VignetteBuilder: knitr
RoxygenNote: 7.2.0
Config/testthat/edition: 3