diff --git a/cloudinit/config/cc_mcollective.py b/cloudinit/config/cc_mcollective.py
index f17f1823b39a..360cc0c09dc6 100644
--- a/cloudinit/config/cc_mcollective.py
+++ b/cloudinit/config/cc_mcollective.py
@@ -9,9 +9,9 @@
 
 """ Mcollective: Install, configure and start mcollective"""
 
-import errno
 import io
 import logging
+from contextlib import suppress
 from textwrap import dedent
 
 # Used since this can maintain comments
@@ -100,15 +100,12 @@ def configure(
     try:
         old_contents = util.load_binary_file(server_cfg, quiet=False)
         mcollective_config = ConfigObj(io.BytesIO(old_contents))
-    except OSError as e:
-        if e.errno != errno.ENOENT:
-            raise
-        else:
-            LOG.debug(
-                "Did not find file %s (starting with an empty config)",
-                server_cfg,
-            )
-            mcollective_config = ConfigObj()
+    except FileNotFoundError:
+        LOG.debug(
+            "Did not find file %s (starting with an empty config)",
+            server_cfg,
+        )
+        mcollective_config = ConfigObj()
     for cfg_name, cfg in config.items():
         if cfg_name == "public-cert":
             util.write_file(pubcert_file, cfg, mode=0o644)
@@ -133,16 +130,10 @@ def configure(
                 # Otherwise just try to convert it to a string
                 mcollective_config[cfg_name] = str(cfg)
 
-    try:
+    with suppress(FileNotFoundError):
         # We got all our config as wanted we'll copy
         # the previous server.cfg and overwrite the old with our new one
         util.copy(server_cfg, "%s.old" % (server_cfg))
-    except OSError as e:
-        if e.errno == errno.ENOENT:
-            # Doesn't exist to copy...
-            pass
-        else:
-            raise
 
     # Now we got the whole (new) file, write to disk...
     contents = io.BytesIO()
diff --git a/cloudinit/config/cc_power_state_change.py b/cloudinit/config/cc_power_state_change.py
index 401d18f14924..d72661c912b9 100644
--- a/cloudinit/config/cc_power_state_change.py
+++ b/cloudinit/config/cc_power_state_change.py
@@ -6,7 +6,6 @@
 
 """Power State Change: Change power state"""
 
-import errno
 import logging
 import os
 import re
@@ -229,8 +228,6 @@ def fatal(msg):
         LOG.warning(msg)
         doexit(EXIT_FAIL)
 
-    known_errnos = (errno.ENOENT, errno.ESRCH)
-
     while True:
         if time.time() > end_time:
             msg = "timeout reached before %s ended" % pid
@@ -241,14 +238,11 @@ def fatal(msg):
             if cmdline != pidcmdline:
                 msg = "cmdline changed for %s [now: %s]" % (pid, cmdline)
                 break
-
-        except OSError as ioerr:
-            if ioerr.errno in known_errnos:
-                msg = "pidfile gone [%d]" % ioerr.errno
-            else:
-                fatal("OSError during wait: %s" % ioerr)
+        except (ProcessLookupError, FileNotFoundError):
+            msg = "pidfile gone"
             break
-
+        except OSError as ioerr:
+            fatal("OSError during wait: %s" % ioerr)
         except Exception as e:
             fatal("Unexpected Exception: %s" % e)
 
diff --git a/cloudinit/config/cc_resizefs.py b/cloudinit/config/cc_resizefs.py
index 394579467988..9f19a5360ace 100644
--- a/cloudinit/config/cc_resizefs.py
+++ b/cloudinit/config/cc_resizefs.py
@@ -8,7 +8,6 @@
 
 """Resizefs: cloud-config module which resizes the filesystem"""
 
-import errno
 import logging
 import os
 import re
@@ -233,19 +232,17 @@ def maybe_get_writable_device_path(devpath, info):
 
     try:
         statret = os.stat(devpath)
-    except OSError as exc:
-        if container and exc.errno == errno.ENOENT:
+    except FileNotFoundError:
+        if container:
             LOG.debug(
                 "Device '%s' did not exist in container. cannot resize: %s",
                 devpath,
                 info,
             )
-        elif exc.errno == errno.ENOENT:
+        else:
             LOG.warning(
                 "Device '%s' did not exist. cannot resize: %s", devpath, info
             )
-        else:
-            raise exc
         return None
 
     if not stat.S_ISBLK(statret.st_mode) and not stat.S_ISCHR(statret.st_mode):
diff --git a/cloudinit/config/schema.py b/cloudinit/config/schema.py
index 3a6e5651cb0c..b8ae3bd372f2 100644
--- a/cloudinit/config/schema.py
+++ b/cloudinit/config/schema.py
@@ -13,7 +13,6 @@
 from contextlib import suppress
 from copy import deepcopy
 from enum import Enum
-from errno import EACCES
 from functools import partial
 from itertools import chain
 from typing import (
@@ -1722,14 +1721,12 @@ def get_processed_or_fallback_path(
 
     try:
         paths = read_cfg_paths(fetch_existing_datasource="trust")
-    except OSError as e:
-        if e.errno == EACCES:
-            LOG.debug(
-                "Using default instance-data/user-data paths for non-root user"
-            )
-            paths = read_cfg_paths()
-        else:
-            raise
+    except PermissionError:
+        LOG.debug(
+            "Using default instance-data/user-data "
+            "paths with insufficient permissions"
+        )
+        paths = read_cfg_paths()
     except DataSourceNotFoundException:
         paths = read_cfg_paths()
         LOG.warning(
diff --git a/cloudinit/net/__init__.py b/cloudinit/net/__init__.py
index 5ad959db1ac3..e5e41e6c7368 100644
--- a/cloudinit/net/__init__.py
+++ b/cloudinit/net/__init__.py
@@ -78,8 +78,10 @@ def read_sys_net_safe(iface, field):
             iface,
             field,
         )
+    except (FileNotFoundError, NotADirectoryError):
+        return False
     except OSError as e:
-        if e.errno in (errno.ENOENT, errno.ENOTDIR, errno.EINVAL):
+        if e.errno == errno.EINVAL:
             return False
         raise
 
diff --git a/cloudinit/sources/DataSourceAltCloud.py b/cloudinit/sources/DataSourceAltCloud.py
index c6cf0bfad01e..c9ade29ddd27 100644
--- a/cloudinit/sources/DataSourceAltCloud.py
+++ b/cloudinit/sources/DataSourceAltCloud.py
@@ -12,7 +12,6 @@
 instance on RHEVm and vSphere.
 """
 
-import errno
 import logging
 import os
 import os.path
@@ -213,9 +212,8 @@ def user_data_rhevm(self):
 
         try:
             return_str = util.mount_cb(floppy_dev, read_user_data_callback)
-        except OSError as err:
-            if err.errno != errno.ENOENT:
-                raise
+        except FileNotFoundError:
+            pass
         except util.MountFailedError:
             util.logexc(
                 LOG,
@@ -253,9 +251,8 @@ def user_data_vsphere(self):
                 if return_str:
                     self.source = cdrom_dev
                     break
-            except OSError as err:
-                if err.errno != errno.ENOENT:
-                    raise
+            except FileNotFoundError:
+                pass
             except util.MountFailedError:
                 util.logexc(
                     LOG,
diff --git a/cloudinit/sources/DataSourceBigstep.py b/cloudinit/sources/DataSourceBigstep.py
index 5342bf1167dc..a592c6db70d8 100644
--- a/cloudinit/sources/DataSourceBigstep.py
+++ b/cloudinit/sources/DataSourceBigstep.py
@@ -4,7 +4,6 @@
 #
 # This file is part of cloud-init. See LICENSE file for license information.
 
-import errno
 import json
 import os
 
@@ -41,16 +40,12 @@ def _get_url_from_file(self):
             self.paths.cloud_dir, "data", "seed", "bigstep", "url"
         )
         try:
-            content = util.load_text_file(url_file)
-        except OSError as e:
+            return util.load_text_file(url_file)
+        except FileNotFoundError:
             # If the file doesn't exist, then the server probably isn't a
             # Bigstep instance; otherwise, another problem exists which needs
             # investigation
-            if e.errno == errno.ENOENT:
-                return None
-            else:
-                raise
-        return content
+            return None
 
 
 # Used to match classes to dependencies
diff --git a/cloudinit/sources/DataSourceNoCloud.py b/cloudinit/sources/DataSourceNoCloud.py
index 9cf686924304..036fdb48ca5f 100644
--- a/cloudinit/sources/DataSourceNoCloud.py
+++ b/cloudinit/sources/DataSourceNoCloud.py
@@ -8,7 +8,6 @@
 #
 # This file is part of cloud-init. See LICENSE file for license information.
 
-import errno
 import logging
 import os
 from functools import partial
@@ -142,9 +141,8 @@ def _pp2d_callback(mp, data):
                     LOG.debug("Using data from %s", dev)
                     found.append(dev)
                     break
-                except OSError as e:
-                    if e.errno != errno.ENOENT:
-                        raise
+                except FileNotFoundError:
+                    pass
                 except util.MountFailedError:
                     util.logexc(
                         LOG, "Failed to mount %s when looking for data", dev
diff --git a/cloudinit/sources/DataSourceRbxCloud.py b/cloudinit/sources/DataSourceRbxCloud.py
index 2fba1149d865..ec2459cba450 100644
--- a/cloudinit/sources/DataSourceRbxCloud.py
+++ b/cloudinit/sources/DataSourceRbxCloud.py
@@ -9,7 +9,6 @@
 This file contains code used to gather the user data passed to an
 instance on rootbox / hyperone cloud platforms
 """
-import errno
 import logging
 import os
 import os.path
@@ -96,9 +95,8 @@ def get_md():
             )
             if rbx_data:
                 return rbx_data
-        except OSError as err:
-            if err.errno != errno.ENOENT:
-                raise
+        except FileNotFoundError:
+            pass
         except util.MountFailedError:
             util.logexc(
                 LOG, "Failed to mount %s when looking for user data", device
diff --git a/cloudinit/sources/DataSourceSmartOS.py b/cloudinit/sources/DataSourceSmartOS.py
index 7c642180cc7e..f5aded12e8b2 100644
--- a/cloudinit/sources/DataSourceSmartOS.py
+++ b/cloudinit/sources/DataSourceSmartOS.py
@@ -22,7 +22,6 @@
 
 import base64
 import binascii
-import errno
 import fcntl
 import json
 import logging
@@ -445,12 +444,8 @@ def as_ascii():
                 if byte == b"\n":
                     return as_ascii()
                 response.append(byte)
-            except OSError as exc:
-                if exc.errno == errno.EAGAIN:
-                    raise JoyentMetadataTimeoutException(
-                        msg % as_ascii()
-                    ) from exc
-                raise
+            except BlockingIOError as e:
+                raise JoyentMetadataTimeoutException(msg % as_ascii()) from e
 
     def _write(self, msg):
         self.fp.write(msg.encode("ascii"))
diff --git a/cloudinit/temp_utils.py b/cloudinit/temp_utils.py
index 957433474aad..9481c732708c 100644
--- a/cloudinit/temp_utils.py
+++ b/cloudinit/temp_utils.py
@@ -1,11 +1,11 @@
 # This file is part of cloud-init. See LICENSE file for license information.
 
 import contextlib
-import errno
 import logging
 import os
 import shutil
 import tempfile
+from contextlib import suppress
 
 from cloudinit import util
 
@@ -71,11 +71,8 @@ def ExtendedTemporaryFile(**kwargs):
     # file to unlink has been unlinked elsewhere..
 
     def _unlink_if_exists(path):
-        try:
+        with suppress(FileNotFoundError):
             os.unlink(path)
-        except OSError as e:
-            if e.errno != errno.ENOENT:
-                raise e
 
     fh.unlink = _unlink_if_exists
 
diff --git a/tests/unittests/cmd/test_query.py b/tests/unittests/cmd/test_query.py
index a0836e977bbc..97bee0f39206 100644
--- a/tests/unittests/cmd/test_query.py
+++ b/tests/unittests/cmd/test_query.py
@@ -1,6 +1,5 @@
 # This file is part of cloud-init. See LICENSE file for license information.
 
-import errno
 import gzip
 import json
 import os
@@ -167,7 +166,7 @@ def test_handle_args_error_when_no_read_permission_instance_data(
             varname=None,
         )
         with mock.patch(M_PATH + "util.load_binary_file") as m_load:
-            m_load.side_effect = OSError(errno.EACCES, "Not allowed")
+            m_load.side_effect = PermissionError("Not allowed")
             assert 1 == query.handle_args("anyname", args)
         msg = "No read permission on '%s'. Try sudo" % noread_fn
         assert msg in caplog.text
@@ -175,8 +174,8 @@ def test_handle_args_error_when_no_read_permission_instance_data(
     @pytest.mark.parametrize(
         "exception",
         [
-            (OSError(errno.EACCES, "Not allowed"),),
-            (OSError(errno.ENOENT, "Not allowed"),),
+            (PermissionError("Not allowed"),),
+            (FileNotFoundError("Not allowed"),),
             (OSError,),
         ],
     )
diff --git a/tests/unittests/config/test_cc_growpart.py b/tests/unittests/config/test_cc_growpart.py
index 44eef5ee1ed4..5e40beddd7dd 100644
--- a/tests/unittests/config/test_cc_growpart.py
+++ b/tests/unittests/config/test_cc_growpart.py
@@ -1,7 +1,6 @@
 # This file is part of cloud-init. See LICENSE file for license information.
 # pylint: disable=attribute-defined-outside-init
 
-import errno
 import logging
 import os
 import re
@@ -361,9 +360,7 @@ def mystat(path):
             if path in devs:
                 return devstat_ret
             if path in enoent:
-                e = OSError("%s: does not exist" % path)
-                e.errno = errno.ENOENT
-                raise e
+                raise FileNotFoundError("%s: does not exist" % path)
             return real_stat(path)
 
         opinfo = self.distro.device_part_info
diff --git a/tests/unittests/config/test_schema.py b/tests/unittests/config/test_schema.py
index 53574fcaec6d..596c895a029d 100644
--- a/tests/unittests/config/test_schema.py
+++ b/tests/unittests/config/test_schema.py
@@ -11,7 +11,6 @@
 import unittest
 from collections import namedtuple
 from copy import deepcopy
-from errno import EACCES
 from pathlib import Path
 from textwrap import dedent
 from types import ModuleType
@@ -2589,8 +2588,11 @@ class TestHandleSchemaArgs:
         "failure, expected_logs",
         (
             (
-                OSError("No permissions on /var/lib/cloud/instance"),
-                ["Using default instance-data/user-data paths for non-root"],
+                PermissionError("No permissions on /var/lib/cloud/instance"),
+                [
+                    "Using default instance-data/user-data paths with "
+                    "insufficient permissions"
+                ],
             ),
             (
                 DataSourceNotFoundException("No cached datasource found yet"),
@@ -2609,8 +2611,6 @@ def test_handle_schema_unable_to_read_cfg_paths(
         caplog,
         tmpdir,
     ):
-        if isinstance(failure, OSError):
-            failure.errno = EACCES
         read_cfg_paths.side_effect = [failure, paths]
         user_data_fn = tmpdir.join("user-data")
         with open(user_data_fn, "w") as f:
diff --git a/tests/unittests/net/test_init.py b/tests/unittests/net/test_init.py
index 9b35a1037408..6dcdeec3748d 100644
--- a/tests/unittests/net/test_init.py
+++ b/tests/unittests/net/test_init.py
@@ -2,7 +2,6 @@
 # pylint: disable=attribute-defined-outside-init
 
 import copy
-import errno
 import ipaddress
 import os
 from pathlib import Path
@@ -532,10 +531,9 @@ def setUp(self):
 
     def test_get_devicelist_raise_oserror(self):
         """get_devicelist raise any non-ENOENT OSerror."""
-        error = OSError("Can not do it")
-        error.errno = errno.EPERM  # Set non-ENOENT
+        error = PermissionError("Can not do it")
         self.m_sys_path.side_effect = error
-        with self.assertRaises(OSError) as context_manager:
+        with self.assertRaises(PermissionError) as context_manager:
             net.get_devicelist()
         exception = context_manager.exception
         self.assertEqual("Can not do it", str(exception))
diff --git a/tests/unittests/test_builtin_handlers.py b/tests/unittests/test_builtin_handlers.py
index 4f3f3a8e4156..fdcf41c0c1cf 100644
--- a/tests/unittests/test_builtin_handlers.py
+++ b/tests/unittests/test_builtin_handlers.py
@@ -3,7 +3,6 @@
 """Tests of the built-in user data handlers."""
 
 import copy
-import errno
 import os
 from textwrap import dedent
 
@@ -191,7 +190,7 @@ def test_jinja_template_handle_errors_on_unreadable_instance_data(self):
         h = JinjaTemplatePartHandler(self.paths, sub_handlers=[script_handler])
         with mock.patch(self.mpath + "load_text_file") as m_load:
             with self.assertRaises(JinjaLoadError) as context_manager:
-                m_load.side_effect = OSError(errno.EACCES, "Not allowed")
+                m_load.side_effect = PermissionError("Not allowed")
                 h.handle_part(
                     data="data",
                     ctype="!" + handlers.CONTENT_START,
diff --git a/tests/unittests/test_util.py b/tests/unittests/test_util.py
index 0fa1507dacd0..0450e2bc82a8 100644
--- a/tests/unittests/test_util.py
+++ b/tests/unittests/test_util.py
@@ -3,7 +3,6 @@
 """Tests for cloudinit.util"""
 
 import base64
-import errno
 import io
 import json
 import logging
@@ -542,7 +541,7 @@ def test_read_conf_with_config_invalid_jinja_syntax(
 
     @mock.patch(
         M_PATH + "read_conf",
-        side_effect=(OSError(errno.EACCES, "Not allowed"), {"0": "0"}),
+        side_effect=(PermissionError("Not allowed"), {"0": "0"}),
     )
     def test_read_conf_d_no_permissions(
         self, m_read_conf, caplog, capsys, tmpdir
@@ -577,7 +576,7 @@ def test_read_conf_d_no_permissions(
     @mock.patch(M_PATH + "mergemanydict")
     @mock.patch(M_PATH + "read_conf_d", return_value={"my_config": "foo"})
     @mock.patch(
-        M_PATH + "read_conf", side_effect=OSError(errno.EACCES, "Not allowed")
+        M_PATH + "read_conf", side_effect=PermissionError("Not allowed")
     )
     def test_read_conf_with_confd_no_permissions(
         self,