diff --git a/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap b/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
index 19555590986d..2f278bf27e08 100644
--- a/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
+++ b/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
@@ -288,6 +288,9 @@ Map {
       "disabled": Object {
         "type": "bool",
       },
+      "disabledFocusable": Object {
+        "type": "bool",
+      },
       "hasIconOnly": Object {
         "type": "bool",
       },
diff --git a/packages/react/src/components/Button/Button.tsx b/packages/react/src/components/Button/Button.tsx
index 260a92943ddb..7a6f1af24801 100644
--- a/packages/react/src/components/Button/Button.tsx
+++ b/packages/react/src/components/Button/Button.tsx
@@ -121,6 +121,7 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
     className,
     dangerDescription = 'danger',
     disabled = false,
+    disabledFocusable = false,
     hasIconOnly = false,
     href,
     iconDescription,
@@ -147,7 +148,7 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
 
   const handleClick = (evt: React.MouseEvent) => {
     // Prevent clicks on the tooltip from triggering the button click event
-    if (evt.target === tooltipRef.current) {
+    if (evt.target === tooltipRef.current || disabledFocusable) {
       evt.preventDefault();
       return;
     }
@@ -162,6 +163,7 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
     [`${prefix}--layout--size-${size}`]: size,
     [`${prefix}--btn--${kind}`]: kind,
     [`${prefix}--btn--disabled`]: disabled,
+    [`${prefix}--btn--disabled-focusable`]: disabledFocusable,
     [`${prefix}--btn--expressive`]: isExpressive,
     [`${prefix}--btn--icon-only`]: hasIconOnly,
     [`${prefix}--btn--selected`]: hasIconOnly && isSelected && kind === 'ghost',
@@ -190,6 +192,7 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
   const { 'aria-pressed': ariaPressed } = rest;
   let otherProps: Partial<ButtonBaseProps> = {
     disabled,
+    'aria-disabled': disabledFocusable ? disabledFocusable : undefined,
     type,
     'aria-describedby': dangerButtonVariants.includes(kind)
       ? assistiveId
@@ -216,7 +219,7 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
       ...otherProps,
       ...anchorProps,
     };
-  } else if (href && !disabled) {
+  } else if (href && !disabled && !disabledFocusable) {
     component = 'a';
     otherProps = anchorProps;
   }
@@ -268,7 +271,9 @@ const Button = React.forwardRef(function Button<T extends React.ElementType>(
         onMouseLeave={onMouseLeave}
         onFocus={onFocus}
         onBlur={onBlur}
-        onClick={composeEventHandlers([onClick, handleClick])}
+        onClick={
+          !disabledFocusable && composeEventHandlers([onClick, handleClick])
+        }
         {...rest}
         {...commonProps}
         {...otherProps}>
@@ -310,6 +315,15 @@ Button.propTypes = {
    */
   disabled: PropTypes.bool,
 
+  /**
+   * Disable the button but still allow it to be focusable.
+   * A Button can only be disabled OR disabledFocusable, not both.
+   * This is useful for when the button needs to remain in the tab
+   * order. This is most commonly used to allow a tooltip to be
+   * rendered on a disabled button to convey the reason why the button is disabled.
+   */
+  disabledFocusable: PropTypes.bool,
+
   /**
    * Specify if the button is an icon-only button
    */
diff --git a/packages/react/src/components/Button/__tests__/Button-test.js b/packages/react/src/components/Button/__tests__/Button-test.js
index 458ef2e99c37..f256b195dfab 100644
--- a/packages/react/src/components/Button/__tests__/Button-test.js
+++ b/packages/react/src/components/Button/__tests__/Button-test.js
@@ -7,6 +7,7 @@
 
 import { Search, Add } from '@carbon/icons-react';
 import { render, screen } from '@testing-library/react';
+import userEvent from '@testing-library/user-event';
 import React from 'react';
 import Button from '../../Button';
 
@@ -45,6 +46,30 @@ describe('Button', () => {
     expect(screen.getByRole('button')).toBeDisabled();
   });
 
+  it('should receive focus when given disabledFocusable', async () => {
+    const onClick = jest.fn();
+    render(
+      <Button disabledFocusable onClick={onClick}>
+        test
+      </Button>
+    );
+    // `toBeDisabled` does not take into account aria-disabled.
+    // this check ensures that the `disabled` attribute is not present
+    expect(screen.getByRole('button')).toBeEnabled();
+
+    expect(screen.getByRole('button')).not.toHaveFocus();
+    await userEvent.tab();
+    expect(screen.getByRole('button')).toHaveFocus();
+
+    await userEvent.click();
+
+    // To adhere to the spec, buttons with aria-disabled must also "implement
+    // the necessary scripting to functionally disable the button, rather than
+    // the use disabled attribute."
+    // https://www.w3.org/TR/html-aria/#docconformance-attr
+    expect(onClick).not.toHaveBeenCalled();
+  });
+
   it('should render with a default button type of button', () => {
     render(<Button>test</Button>);
     expect(screen.getByRole('button')).toHaveAttribute('type', 'button');
diff --git a/packages/styles/scss/components/button/_button.scss b/packages/styles/scss/components/button/_button.scss
index f68157c4eb60..3688ab164056 100644
--- a/packages/styles/scss/components/button/_button.scss
+++ b/packages/styles/scss/components/button/_button.scss
@@ -101,6 +101,14 @@
       color: $text-on-color-disabled;
       outline: none;
     }
+
+    &.#{$prefix}--btn--disabled-focusable,
+    &.#{$prefix}--btn--disabled-focusable:hover,
+    &.#{$prefix}--btn--disabled-focusable:focus {
+      background: transparent;
+      color: $text-on-color-disabled;
+      outline: none;
+    }
   }
 
   .#{$prefix}--btn--ghost {
@@ -146,6 +154,18 @@
     &:not([disabled]) svg {
       fill: $icon-primary;
     }
+
+    &.#{$prefix}--btn--disabled-focusable,
+    &.#{$prefix}--btn--disabled-focusable:hover,
+    &.#{$prefix}--btn--disabled-focusable:focus {
+      background: transparent;
+      color: $text-on-color-disabled;
+      outline: none;
+    }
+
+    &:not(.#{$prefix}--btn--disabled-focusable) svg {
+      fill: $icon-primary;
+    }
   }
 
   .#{$prefix}--btn--icon-only {
@@ -265,6 +285,14 @@
         color: $text-on-color-disabled;
         outline: none;
       }
+
+      &.#{$prefix}--btn--disabled-focusable,
+      &.#{$prefix}--btn--disabled-focusable:hover,
+      &.#{$prefix}--btn--disabled-focusable:focus {
+        background: transparent;
+        color: $text-on-color-disabled;
+        outline: none;
+      }
     }
 
     &--ghost {
@@ -302,6 +330,14 @@
         color: $text-disabled;
         outline: none;
       }
+
+      &.#{$prefix}--btn--disabled-focusable,
+      &.#{$prefix}--btn--disabled-focusable:hover,
+      &.#{$prefix}--btn--disabled-focusable:focus {
+        background: transparent;
+        color: $text-disabled;
+        outline: none;
+      }
     }
   }
 
@@ -374,7 +410,8 @@
     box-shadow: inherit;
   }
 
-  .#{$prefix}--btn-set .#{$prefix}--btn.#{$prefix}--btn--disabled {
+  .#{$prefix}--btn-set .#{$prefix}--btn.#{$prefix}--btn--disabled,
+  .#{$prefix}--btn-set .#{$prefix}--btn.#{$prefix}--btn--disabled-focusable {
     box-shadow: convert.to-rem(-1px) 0 0 0 $icon-on-color-disabled;
 
     &:first-of-type {
@@ -382,7 +419,9 @@
     }
   }
 
-  .#{$prefix}--btn-set--stacked .#{$prefix}--btn.#{$prefix}--btn--disabled {
+  .#{$prefix}--btn-set--stacked .#{$prefix}--btn.#{$prefix}--btn--disabled,
+  .#{$prefix}--btn-set--stacked
+    .#{$prefix}--btn.#{$prefix}--btn--disabled-focusable {
     box-shadow: 0 convert.to-rem(-1px) 0 0 $layer-selected-disabled;
 
     &:first-of-type {
diff --git a/packages/styles/scss/components/button/_mixins.scss b/packages/styles/scss/components/button/_mixins.scss
index 5cc4b79b5cef..1121f924a638 100644
--- a/packages/styles/scss/components/button/_mixins.scss
+++ b/packages/styles/scss/components/button/_mixins.scss
@@ -89,6 +89,15 @@ $button-focus-color: custom-property.get-var('button-focus-color', $focus);
     cursor: not-allowed;
   }
 
+  &.#{$prefix}--btn--disabled-focusable,
+  &.#{$prefix}--btn--disabled-focusable:hover,
+  &.#{$prefix}--btn--disabled-focusable:focus {
+    background: $button-disabled;
+    box-shadow: none;
+    color: $text-on-color-disabled;
+    cursor: not-allowed;
+  }
+
   .#{$prefix}--btn__icon {
     position: absolute;
     flex-shrink: 0;