diff --git a/vcfanno/crg.vcfanno_hg38.conf b/vcfanno/crg.vcfanno_hg38.conf
index cbd95a4..dd0314a 100644
--- a/vcfanno/crg.vcfanno_hg38.conf
+++ b/vcfanno/crg.vcfanno_hg38.conf
@@ -1,52 +1,9 @@
-#gnomad v.2.1.1 exomes (lifted over)
+#gnomad v.4.1.0 merged joint frequency (hg38)
 [[annotation]]
-file="gnomad_exome.2.1.1_LIFTOVER.vcf.gz"
-fields=["AC","nhomalt","AF_popmax","AN","AC_male"]
-names=["gnomad_ac_es","gnomad_hom_es","gnomad_af_es","gnomad_an_es","gnomad_male_ac_es"]
-ops=["self","self","self","self","self"]
-
-#gnomad v.3.1.2 genomes (native hg38)
-[[annotation]]
-file="gnomad_genomes_v.3.1.2.vcf.gz"
-fields=["AC", "nhomalt","AF_popmax","AN","AC_XY"]
-names=["gnomad_ac_gs", "gnomad_hom_gs","gnomad_af_gs","gnomad_an_gs","gnomad_male_ac_gs"]
-ops=["self","self","self","self","self"]
-
-[[postannotation]]
-fields=["gnomad_ac_es","gnomad_ac_gs"]
-op="sum"
-name="gnomad_ac"
-type="Integer"
-
-[[postannotation]]
-fields=["gnomad_hom_es","gnomad_hom_gs"]
-op="sum"
-name="gnomad_hom"
-type="Integer"
-
-[[postannotation]]
-fields=["gnomad_af_es","gnomad_af_gs"]
-op="max"
-name="gnomad_af_popmax"
-type="Float"
-
-[[postannotation]]
-fields=["gnomad_an_es","gnomad_an_gs"]
-op="sum"
-name="gnomad_an"
-type="Integer"
-
-[[postannotation]]
-fields=["gnomad_ac","gnomad_an"]
-op="div2"
-name="gnomad_af"
-type="Float"
-
-[[postannotation]]
-fields=["gnomad_male_ac_es","gnomad_male_ac_gs"]
-op="sum"
-name="gnomad_male_ac"
-type="Integer"
+file="gnomad_merged_joint_frequencies_v4.1.0.vcf.gz"
+fields=["AC_joint", "nhomalt_joint","AF_joint","AF_grpmax_joint","AN_joint","AC_joint_XY","fafmax_faf95_max_joint","FILTER"]
+names=["gnomad_ac", "gnomad_hom","gnomad_af","gnomad_af_grpmax","gnomad_an","gnomad_male_ac","gnomad_fafmax_faf95_max","gnomad_filter"]
+ops=["self","self","self","self","self","self","self","self"]
 
 [[annotation]]
 file="dbsnp-151.vcf.gz"