diff --git a/.changeset/happy-mirrors-worry.md b/.changeset/happy-mirrors-worry.md
new file mode 100644
index 000000000000..20771a04a9c3
--- /dev/null
+++ b/.changeset/happy-mirrors-worry.md
@@ -0,0 +1,7 @@
+---
+"wrangler": patch
+---
+
+feature:Add warning about deploying Python with requirements.txt
+
+This expands on the warning shown for all Python Workers to include a message about deploying Python Workers with a requirements.txt not being supported.
diff --git a/packages/wrangler/src/deployment-bundle/guess-worker-format.ts b/packages/wrangler/src/deployment-bundle/guess-worker-format.ts
index a2f81419d319..d8d8df0a295c 100644
--- a/packages/wrangler/src/deployment-bundle/guess-worker-format.ts
+++ b/packages/wrangler/src/deployment-bundle/guess-worker-format.ts
@@ -26,7 +26,7 @@ export default async function guessWorkerFormat(
 			`The entrypoint ${path.relative(
 				process.cwd(),
 				entryFile
-			)} defines a Python worker, support for Python workers is currently experimental.`
+			)} defines a Python worker, support for Python workers is currently experimental. Python workers with a requirements.txt file can only be run locally and cannot be deployed.`
 		);
 		return "modules";
 	}