diff --git a/pkg/ui/workspaces/cluster-ui/src/api/databases/getDatabaseMetadataApi.ts b/pkg/ui/workspaces/cluster-ui/src/api/databases/getDatabaseMetadataApi.ts
index d75510abd122..88557511332f 100644
--- a/pkg/ui/workspaces/cluster-ui/src/api/databases/getDatabaseMetadataApi.ts
+++ b/pkg/ui/workspaces/cluster-ui/src/api/databases/getDatabaseMetadataApi.ts
@@ -41,7 +41,7 @@ export type DatabaseMetadataRequest = {
   sortBy?: string;
   sortOrder?: string;
   pagination: SimplePaginationState;
-  storeId?: number;
+  storeIds?: number[];
 };
 
 export type DatabaseMetadataResponse =
@@ -64,8 +64,8 @@ export const getDatabaseMetadata = async (req: DatabaseMetadataRequest) => {
   if (req.pagination.pageNum) {
     urlParams.append("pageNum", req.pagination.pageNum.toString());
   }
-  if (req.storeId) {
-    urlParams.append("storeId", req.storeId.toString());
+  if (req.storeIds?.length) {
+    req.storeIds.forEach(id => urlParams.append("storeId", id.toString()));
   }
 
   return fetchDataJSON<DatabaseMetadataResponse, DatabaseMetadataRequest>(
@@ -74,7 +74,7 @@ export const getDatabaseMetadata = async (req: DatabaseMetadataRequest) => {
 };
 
 const createKey = (req: DatabaseMetadataRequest) => {
-  const { name, sortBy, sortOrder, pagination, storeId } = req;
+  const { name, sortBy, sortOrder, pagination, storeIds } = req;
   return [
     "databaseMetadata",
     name,
@@ -82,7 +82,7 @@ const createKey = (req: DatabaseMetadataRequest) => {
     sortOrder,
     pagination.pageSize,
     pagination.pageNum,
-    storeId,
+    storeIds.map(sid => sid.toString()).join(","),
   ].join("|");
 };
 
diff --git a/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.spec.tsx b/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.spec.tsx
new file mode 100644
index 000000000000..5f443837cf51
--- /dev/null
+++ b/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.spec.tsx
@@ -0,0 +1,129 @@
+// Copyright 2024 The Cockroach Authors.
+//
+// Use of this software is governed by the Business Source License
+// included in the file licenses/BSL.txt.
+//
+// As of the Change Date specified in that file, in accordance with
+// the Business Source License, use of this software will be governed
+// by the Apache License, Version 2.0, included in the file
+// licenses/APL.txt.
+
+import { render, screen, fireEvent, waitFor } from "@testing-library/react";
+import React from "react";
+
+import { useNodeStatuses } from "src/api";
+import { getRegionFromLocality } from "src/store/nodes";
+import { StoreID } from "src/types/clusterTypes";
+
+import { NodeRegionsSelector } from "./nodeRegionsSelector";
+
+// Mock the useNodeStatuses hook
+jest.mock("src/api", () => ({
+  useNodeStatuses: jest.fn(),
+}));
+
+// Mock the getRegionFromLocality function
+jest.mock("src/store/nodes", () => ({
+  getRegionFromLocality: jest.fn(),
+}));
+
+const mockNodeData = {
+  nodes: [
+    {
+      desc: { node_id: 1, locality: { region: "us-east" } },
+      store_statuses: [
+        { desc: { store_id: 101 } },
+        { desc: { store_id: 102 } },
+      ],
+    },
+    {
+      desc: { node_id: 2, locality: { region: "us-west" } },
+      store_statuses: [{ desc: { store_id: 201 } }],
+    },
+    {
+      desc: { node_id: 3, locality: { region: "us-east" } },
+      store_statuses: [{ desc: { store_id: 301 } }],
+    },
+  ],
+};
+
+describe("NodeRegionsSelector", () => {
+  beforeEach(() => {
+    (useNodeStatuses as jest.Mock).mockReturnValue({
+      isLoading: false,
+      data: mockNodeData,
+    });
+    (getRegionFromLocality as jest.Mock).mockImplementation(
+      locality => locality.region,
+    );
+  });
+
+  it("should render", () => {
+    render(<NodeRegionsSelector value={[]} onChange={() => {}} />);
+    expect(screen.getByText("Nodes")).toBeTruthy();
+  });
+
+  it("displays correct options based on node data", async () => {
+    render(<NodeRegionsSelector value={[]} onChange={() => {}} />);
+
+    const select = screen.getByText("Nodes");
+    fireEvent.keyDown(select, { key: "ArrowDown" });
+
+    await waitFor(() => {
+      expect(screen.getByText("us-east")).toBeTruthy();
+      expect(screen.getByText("us-west")).toBeTruthy();
+      expect(screen.getByText("n1")).toBeTruthy();
+      expect(screen.getByText("n2")).toBeTruthy();
+      expect(screen.getByText("n3")).toBeTruthy();
+    });
+  });
+
+  it("calls onChange with correct values when selecting options", async () => {
+    const value: StoreID[] = [];
+    const mockOnChange = jest.fn((selected: StoreID[]) => {
+      value.push(...selected);
+    });
+    render(<NodeRegionsSelector value={value} onChange={mockOnChange} />);
+
+    const select = screen.getByText("Nodes");
+    fireEvent.keyDown(select, { key: "ArrowDown" });
+
+    await waitFor(() => {
+      fireEvent.click(screen.getByText("n1"));
+    });
+
+    expect(mockOnChange).toHaveBeenCalledWith([101, 102]);
+  });
+
+  it("displays selected values correctly", () => {
+    render(
+      <NodeRegionsSelector
+        value={[101 as StoreID, 201 as StoreID]}
+        onChange={() => {}}
+      />,
+    );
+
+    expect(screen.getByText("n1")).toBeTruthy();
+    expect(screen.getByText("n2")).toBeTruthy();
+  });
+
+  it("handles loading state", () => {
+    (useNodeStatuses as jest.Mock).mockReturnValue({
+      isLoading: true,
+      data: mockNodeData,
+    });
+
+    render(<NodeRegionsSelector value={[]} onChange={() => {}} />);
+
+    const select = screen.getByText("Nodes");
+    fireEvent.keyDown(select, { key: "ArrowDown" });
+
+    // In the loading state, the component should still render options
+    // based on the existing data
+    expect(screen.getByText("us-east")).toBeTruthy();
+    expect(screen.getByText("us-west")).toBeTruthy();
+    expect(screen.getByText("n1")).toBeTruthy();
+    expect(screen.getByText("n2")).toBeTruthy();
+    expect(screen.getByText("n3")).toBeTruthy();
+  });
+});
diff --git a/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.tsx b/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.tsx
new file mode 100644
index 000000000000..10d41d46beb2
--- /dev/null
+++ b/pkg/ui/workspaces/cluster-ui/src/components/nodeRegionsSelector/nodeRegionsSelector.tsx
@@ -0,0 +1,86 @@
+// Copyright 2024 The Cockroach Authors.
+//
+// Use of this software is governed by the Business Source License
+// included in the file licenses/BSL.txt.
+//
+// As of the Change Date specified in that file, in accordance with
+// the Business Source License, use of this software will be governed
+// by the Apache License, Version 2.0, included in the file
+// licenses/APL.txt.
+
+import React, { useMemo } from "react";
+import Select, { OptionsType } from "react-select";
+
+import { useNodeStatuses } from "src/api";
+import { getRegionFromLocality } from "src/store/nodes";
+import { NodeID, StoreID } from "src/types/clusterTypes";
+import {
+  GroupedReactSelectOption,
+  ReactSelectOption,
+} from "src/types/selectTypes";
+
+type NodeRegionsSelectorProps = {
+  value: StoreID[];
+  onChange: (selected: StoreID[]) => void;
+};
+
+export const NodeRegionsSelector: React.FC<NodeRegionsSelectorProps> = ({
+  value,
+  onChange,
+}) => {
+  const nodesResp = useNodeStatuses();
+
+  const nodeOptions: GroupedReactSelectOption<StoreID[]>[] = useMemo(() => {
+    const optionsMap: Record<string, { nid: NodeID; sids: StoreID[] }[]> = {};
+    if (nodesResp.isLoading && !nodesResp.data?.nodes) {
+      return [];
+    }
+
+    nodesResp.data.nodes.forEach(node => {
+      const region = getRegionFromLocality(node.desc.locality);
+      if (optionsMap[region] == null) {
+        optionsMap[region] = [];
+      }
+      optionsMap[region].push({
+        nid: node.desc.node_id as NodeID,
+        sids: node.store_statuses.map(s => s.desc.store_id as StoreID),
+      });
+    });
+
+    return Object.entries(optionsMap).map(([region, nodes]) => {
+      return {
+        label: region,
+        options: nodes.map(n => ({
+          label: `n${n.nid}`,
+          value: n.sids,
+        })),
+      };
+    });
+  }, [nodesResp]);
+
+  const onSelectChange = (
+    selected: OptionsType<ReactSelectOption<StoreID[]>>,
+  ) => {
+    onChange(selected.map(s => s.value).reduce((acc, v) => acc.concat(v), []));
+  };
+
+  const selectValue: OptionsType<ReactSelectOption<StoreID[]>> =
+    nodeOptions.reduce((acc, region) => {
+      const nodes = region.options.filter(n =>
+        value.some(v => n.value.includes(v)),
+      );
+      return [...acc, ...nodes];
+    }, []);
+
+  return (
+    <Select
+      placeholder={"Nodes"}
+      name="nodeRegions"
+      options={nodeOptions}
+      clearable={true}
+      isMulti
+      value={selectValue}
+      onChange={onSelectChange}
+    />
+  );
+};
diff --git a/pkg/ui/workspaces/cluster-ui/src/databasesV2/index.tsx b/pkg/ui/workspaces/cluster-ui/src/databasesV2/index.tsx
index 91a8f67f34b1..b2909b05fa68 100644
--- a/pkg/ui/workspaces/cluster-ui/src/databasesV2/index.tsx
+++ b/pkg/ui/workspaces/cluster-ui/src/databasesV2/index.tsx
@@ -9,9 +9,8 @@
 // licenses/APL.txt.
 
 import { Skeleton } from "antd";
-import React, { useMemo, useState } from "react";
+import React, { useMemo } from "react";
 import { Link } from "react-router-dom";
-import Select, { OptionsType } from "react-select";
 
 import {
   DatabaseMetadataRequest,
@@ -32,20 +31,16 @@ import {
   TableColumnProps,
 } from "src/sharedFromCloud/table";
 import useTable, { TableParams } from "src/sharedFromCloud/useTable";
-import { ReactSelectOption } from "src/types/selectTypes";
 import { Bytes } from "src/util";
 
 import { useNodeStatuses } from "../api";
+import { NodeRegionsSelector } from "../components/nodeRegionsSelector/nodeRegionsSelector";
+import { StoreID } from "../types/clusterTypes";
 
 import { DatabaseColName } from "./constants";
 import { DatabaseRow } from "./databaseTypes";
 import { rawDatabaseMetadataToDatabaseRows } from "./utils";
 
-const mockRegionOptions = [
-  { label: "US East (N. Virginia)", value: "us-east-1" },
-  { label: "US East (Ohio)", value: "us-east-2" },
-];
-
 const COLUMNS: (TableColumnProps<DatabaseRow> & {
   sortKey?: DatabaseSortOptions;
 })[] = [
@@ -131,11 +126,12 @@ const createDatabaseMetadataRequestFromParams = (
     sortBy: params.sort?.field ?? "name",
     sortOrder: params.sort?.order ?? "asc",
     name: params.search,
+    storeIds: params.filters.storeIDs.map(sid => parseInt(sid, 10)),
   };
 };
 
 export const DatabasesPageV2 = () => {
-  const { params, setSort, setSearch, setPagination } = useTable({
+  const { params, setFilters, setSort, setSearch, setPagination } = useTable({
     initial: initialParams,
   });
 
@@ -145,13 +141,10 @@ export const DatabasesPageV2 = () => {
   const nodesResp = useNodeStatuses();
   const paginationState = data?.pagination_info;
 
-  const [nodeRegions, setNodeRegions] = useState<ReactSelectOption<string>[]>(
-    [],
-  );
-  const onNodeRegionsChange = (
-    selected: OptionsType<ReactSelectOption<string>>,
-  ) => {
-    setNodeRegions((selected ?? []).map(v => v));
+  const onNodeRegionsChange = (storeIDs: StoreID[]) => {
+    setFilters({
+      storeIDs: storeIDs.map(sid => sid.toString()),
+    });
   };
 
   const tableData = useMemo(
@@ -194,6 +187,10 @@ export const DatabasesPageV2 = () => {
     [sort],
   );
 
+  const nodeRegionsValue = params.filters.storeIDs.map(
+    sid => parseInt(sid, 10) as StoreID,
+  );
+
   return (
     <PageLayout>
       <PageHeader title="Databases" />
@@ -203,13 +200,8 @@ export const DatabasesPageV2 = () => {
             <Search placeholder="Search databases" onSubmit={setSearch} />
           </PageConfigItem>
           <PageConfigItem minWidth={"200px"}>
-            <Select
-              placeholder={"Regions"}
-              name="nodeRegions"
-              options={mockRegionOptions}
-              clearable={true}
-              isMulti
-              value={nodeRegions}
+            <NodeRegionsSelector
+              value={nodeRegionsValue}
               onChange={onNodeRegionsChange}
             />
           </PageConfigItem>
diff --git a/pkg/ui/workspaces/cluster-ui/src/types/selectTypes.ts b/pkg/ui/workspaces/cluster-ui/src/types/selectTypes.ts
index d8f72058fa23..7aa1b5bd98d2 100644
--- a/pkg/ui/workspaces/cluster-ui/src/types/selectTypes.ts
+++ b/pkg/ui/workspaces/cluster-ui/src/types/selectTypes.ts
@@ -15,3 +15,8 @@ export type ReactSelectOption<T> = {
   label: string;
   value: T;
 };
+
+export type GroupedReactSelectOption<T> = {
+  label: string;
+  options: ReactSelectOption<T>[];
+};