diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
new file mode 100644
index 00000000..a2d1ca5e
--- /dev/null
+++ b/.github/workflows/ci.yml
@@ -0,0 +1,49 @@
+name: Python CI
+
+on: [push, pull_request]
+
+jobs:
+  build:
+    runs-on: ubuntu-latest
+    strategy:
+      matrix:
+        python-version: [3.7, 3.8, 3.9]
+
+    steps:
+    - uses: actions/checkout@v2
+
+    - name: Set up Python ${{ matrix.python-version }}
+      uses: actions/setup-python@v2
+      with:
+        python-version: ${{ matrix.python-version }}
+
+    - name: Cache pip
+      uses: actions/cache@v2
+      with:
+        path: ~/.cache/pip
+        key: ${{ runner.os }}-pip-${{ hashFiles('**/requirements.txt') }}
+        restore-keys: |
+          ${{ runner.os }}-pip-
+
+    - name: Install dependencies
+      run: |
+        sudo apt-get install -qq phyml
+        pip install --upgrade pip setuptools wheel
+        pip install --only-binary=numpy,scipy numpy scipy
+        pip install matplotlib ipython jupyter sympy pytest codecov pytest-cov
+        pip install -r requirements.txt
+        pip install .
+
+    - name: Run tests
+      run: pytest --cov-report=xml --cov=OrthoEvol tests/
+
+    - name: Upload coverage to Codecov
+      uses: codecov/codecov-action@v2
+      with:
+        token: ${{ secrets.CODECOV_TOKEN }}
+        files: ./coverage.xml
+        fail_ci_if_error: true
+
+    - name: Notify failure
+      if: failure()
+      run: echo "Build failed"