diff --git a/src/Microsoft.Data.Sqlite.Core/SqliteBlob.cs b/src/Microsoft.Data.Sqlite.Core/SqliteBlob.cs
index bbcb2a263ef..7e1088b8cb8 100644
--- a/src/Microsoft.Data.Sqlite.Core/SqliteBlob.cs
+++ b/src/Microsoft.Data.Sqlite.Core/SqliteBlob.cs
@@ -206,8 +206,12 @@ public virtual int Read(Span<byte> buffer)
                 count = (int)(Length - position);
             }
 
-            var rc = sqlite3_blob_read(_blob, buffer.Slice(0, count), (int)position);
-            SqliteException.ThrowExceptionForRC(rc, _connection.Handle);
+            // Newer sqlite3_blob_read returns error for 0-byte reads.
+            if (count > 0)
+            {
+                var rc = sqlite3_blob_read(_blob, buffer.Slice(0, count), (int)position);
+                SqliteException.ThrowExceptionForRC(rc, _connection.Handle);
+            }
             _position += count;
             return count;
         }
@@ -280,8 +284,12 @@ public virtual void Write(ReadOnlySpan<byte> buffer)
                 throw new NotSupportedException(Resources.ResizeNotSupported);
             }
 
-            var rc = sqlite3_blob_write(_blob, buffer.Slice(0, count), (int)position);
-            SqliteException.ThrowExceptionForRC(rc, _connection.Handle);
+            // Newer sqlite3_blob_write returns error for 0-byte writes.
+            if (count > 0)
+            {
+                var rc = sqlite3_blob_write(_blob, buffer.Slice(0, count), (int)position);
+                SqliteException.ThrowExceptionForRC(rc, _connection.Handle);
+            }
             _position += count;
         }