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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8" />
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" />
<meta name="description" content="" />
<meta name="author" content="" />
<title>Action & Ageing</title>
<link rel="icon" type="image/x-icon" href="assets/favicon2.ico" />
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rel="stylesheet" />
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<body id="page-top">
<!-- Navigation-->
<nav class="navbar navbar-expand-lg navbar-light fixed-top" id="mainNav">
<div class="container px-4 px-lg-5">
<a class="navbar-brand" href="#page-top">Action & Ageing</a>
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Menu
<i class="fas fa-bars"></i>
</button>
<div class="collapse navbar-collapse" id="navbarResponsive">
<ul class="navbar-nav ms-auto">
<li class="nav-item"><a class="nav-link" href="#about">About</a></li>
<li class="nav-item"><a class="nav-link" href="#projects">Representative Projects</a></li>
<li class="nav-item"><a class="nav-link" href="#contact">Contact</a></li>
</ul>
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<div class="container px-4 px-lg-5 d-flex h-100 align-items-center justify-content-center">
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<div class="text-center">
<h1 class="mx-auto my-0 text-uppercase">Cognitive Neuroscience</h1>
<h2 class="text-white-50 mx-auto mt-2 mb-5">Ethan Knights</h2>
<a class="btn btn-primary" href="#about">Learn More</a>
</div>
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</div>
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<!-- About-->
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<div class="col-lg-8">
<h2 class="text-white mb-4">Understanding brain representations of motor control</h2>
<p class="text-white-50">
Our behavioural & brain imaging (fMRI, MEG) experiments aim to identify
the neural mechanisms that govern human movement
(think, reaching for your coffee) and clarify how they are
affected by healthy ageing.<br><br>
For this, we regularly apply machine learning & big-data approaches.<br>
<a href="#projects"> See latest representative examples</a>.
<br><br>
The
<a href="#page-top"> Action & Ageing</a>
initiative is led by Ethan Knights. <br>Ethan is currently based at the
University of Cambridge acting as the Data Manager for the Cambridge Centre for Ageing and
Neuroscience (Cam-CAN).
<br><br>
Interested & want to gain research experience? <br>
<a href="#contact"> Get in touch</a>.
</p>
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<div class="col-lg-6"><img class="img-fluid" src="assets/img/HAROLD_syn.jpg" alt="..." /></div>
<div class="col-lg-6">
<div class="bg-black text-center h-100 project">
<div class="d-flex h-100">
<div class="project-text w-100 my-auto text-center text-lg-left">
<h4 class="text-white">Dedifferentation of motor cortex in healthy ageing</h4>
<p class="mb-0 text-white-50">
Using two lifespan fMRI datasets, we refuted the hypothesis that reduced motor
lateralisation in older adults compensates for age-related decline. Instead, results demonstrate
that this hyperactivation is non-specific, perhaps reflecting interhemispheric inhibition. <br>
<a href="https://www.jneurosci.org/content/early/2021/09/27/JNEUROSCI.1111-21.2021">
Journal of Neuroscience <br>(Open Access) </a><br>
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</div>
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<!-- Project Two Row-->
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<div class="col-lg-6"><img class="img-fluid" src="assets/img/tools_syn.jpg" alt="..." /></div>
<div class="col-lg-6 order-lg-first">
<div class="bg-black text-center h-100 project">
<div class="d-flex h-100">
<div class="project-text w-100 my-auto text-center text-lg-right">
<h4 class="text-white">How the Human Brain Grasps Tools</h4>
<p class="mb-0 text-white-50">
A grasping fMRI experiment tested which brain regions represented actions
with 3D-printed kitchen tools, like a knife
(<a href="https://www.osf.io/gsmyw/">video example</a>).
As covered by <a
href="https://www.nature.com/articles/d41586-021-01261-y">Nature</a>,
the results mark an important step toward uncovering which brain regions evolved to
support tool-use,
a defining feature of our species. <br>
<a href="https://www.jneurosci.org/content/41/24/5263/">
Journal of Neuroscience <br>(Open Access) </a><br>
</p>
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data-doi="10.1523/JNEUROSCI.0083-21.2021" data-style="small_circle"
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data-badge-popover="bottom" data-hide-no-mentions="true" data-hide-less-than="0"
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data-popup="bottom" data-size="medium" class="plumx-plum-print-popup"
data-site="plum" data-hide-when-empty="true">Hand-selective visual regions
represent how to grasp 3D tools: Brain decoding during real actions</a>
</div>
</section>
</div>
</div>
</div>
</div>
</div>
</div>
</section>
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<h4 class="text-uppercase m-0">Medical Research Council Cognition and Brain Science Unit
</h4>
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<div class="small text-black-50">15 Chaucer Road, Cambridge, UK</div>
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