diff --git a/velox/functions/prestosql/tests/UuidFunctionsTest.cpp b/velox/functions/prestosql/tests/UuidFunctionsTest.cpp
index a66a9ff5adbb2..4fc636d966f35 100644
--- a/velox/functions/prestosql/tests/UuidFunctionsTest.cpp
+++ b/velox/functions/prestosql/tests/UuidFunctionsTest.cpp
@@ -63,7 +63,7 @@ TEST_F(UuidFunctionsTest, castAsVarchar) {
   // Verify that CAST results as the same as boost::lexical_cast. We do not use
   // boost::lexical_cast to implement CAST because it is too slow.
   auto expected = makeFlatVector<std::string>(size, [&](auto row) {
-    const auto uuid = uuids->valueAt(row);
+    const auto uuid = DecimalUtil::bigEndian(uuids->valueAt(row));
 
     boost::uuids::uuid u;
     memcpy(&u, &uuid, 16);
diff --git a/velox/functions/prestosql/types/UuidType.cpp b/velox/functions/prestosql/types/UuidType.cpp
index 5aa420113a69d..b97d5f3d57353 100644
--- a/velox/functions/prestosql/types/UuidType.cpp
+++ b/velox/functions/prestosql/types/UuidType.cpp
@@ -75,7 +75,8 @@ class UuidCastOperator : public exec::CastOperator {
     const auto* uuids = input.as<SimpleVector<int128_t>>();
 
     context.applyToSelectedNoThrow(rows, [&](auto row) {
-      const auto uuid = uuids->valueAt(row);
+      // Ensure UUID bytes are big endian when building the string.
+      const auto uuid = DecimalUtil::bigEndian(uuids->valueAt(row));
 
       const uint8_t* uuidBytes = reinterpret_cast<const uint8_t*>(&uuid);
 
@@ -127,6 +128,9 @@ class UuidCastOperator : public exec::CastOperator {
       int128_t u;
       memcpy(&u, &uuid, 16);
 
+      // Convert a big endian value from Boost to native byte-order.
+      u = DecimalUtil::bigEndian(u);
+
       flatResult->set(row, u);
     });
   }
diff --git a/velox/serializers/PrestoSerializer.cpp b/velox/serializers/PrestoSerializer.cpp
index 2ae3207457aa6..403d3d3516346 100644
--- a/velox/serializers/PrestoSerializer.cpp
+++ b/velox/serializers/PrestoSerializer.cpp
@@ -23,6 +23,7 @@
 #include "velox/common/base/IOUtils.h"
 #include "velox/common/base/RawVector.h"
 #include "velox/common/memory/ByteStream.h"
+#include "velox/functions/prestosql/types/UuidType.h"
 #include "velox/vector/BiasVector.h"
 #include "velox/vector/ComplexVector.h"
 #include "velox/vector/DictionaryVector.h"
@@ -429,6 +430,42 @@ void readDecimalValues(
   if (nullCount) {
     checkValuesSize<int128_t>(values, nulls, size, offset);
 
+    vector_size_t toClear = offset;
+    bits::forEachSetBit(
+        nulls->as<uint64_t>(), offset, offset + size, [&](vector_size_t row) {
+          // Set the values between the last non-null and this to type default.
+          for (; toClear < row; ++toClear) {
+            rawValues[toClear] = 0;
+          }
+          rawValues[row] = readJavaDecimal(source);
+          toClear = row + 1;
+        });
+  } else {
+    for (vector_size_t row = 0; row < size; ++row) {
+      rawValues[offset + row] = readJavaDecimal(source);
+    }
+  }
+}
+
+int128_t readUuidValue(ByteInputStream* source) {
+  // ByteInputStream does not support reading int128_t values.
+  // UUIDs are serialized as 2 uint64 values with msb value first.
+  auto high = folly::Endian::big(source->read<uint64_t>());
+  auto low = folly::Endian::big(source->read<uint64_t>());
+  return HugeInt::build(high, low);
+}
+
+void readUuidValues(
+    ByteInputStream* source,
+    vector_size_t size,
+    vector_size_t offset,
+    const BufferPtr& nulls,
+    vector_size_t nullCount,
+    const BufferPtr& values) {
+  auto rawValues = values->asMutable<int128_t>();
+  if (nullCount) {
+    checkValuesSize<int128_t>(values, nulls, size, offset);
+
     int32_t toClear = offset;
     bits::forEachSetBit(
         nulls->as<uint64_t>(), offset, offset + size, [&](int32_t row) {
@@ -436,12 +473,12 @@ void readDecimalValues(
           for (; toClear < row; ++toClear) {
             rawValues[toClear] = 0;
           }
-          rawValues[row] = readJavaDecimal(source);
+          rawValues[row] = readUuidValue(source);
           toClear = row + 1;
         });
   } else {
     for (int32_t row = 0; row < size; ++row) {
-      rawValues[offset + row] = readJavaDecimal(source);
+      rawValues[offset + row] = readUuidValue(source);
     }
   }
 }
@@ -569,6 +606,16 @@ void read(
         values);
     return;
   }
+  if (isUuidType(type)) {
+    readUuidValues(
+        source,
+        numNewValues,
+        resultOffset,
+        flatResult->nulls(),
+        nullCount,
+        values);
+    return;
+  }
   readValues<T>(
       source,
       numNewValues,
@@ -1427,6 +1474,7 @@ class VectorStream {
         useLosslessTimestamp_(opts.useLosslessTimestamp),
         nullsFirst_(opts.nullsFirst),
         isLongDecimal_(type_->isLongDecimal()),
+        isUuid_(isUuidType(type_)),
         opts_(opts),
         encoding_(getEncoding(encoding, vector)),
         nulls_(streamArena, true, true),
@@ -1778,6 +1826,10 @@ class VectorStream {
     return isLongDecimal_;
   }
 
+  bool isUuid() const {
+    return isUuid_;
+  }
+
   void clear() {
     encoding_ = std::nullopt;
     initializeHeader(typeToEncodingName(type_), *streamArena_);
@@ -1858,6 +1910,7 @@ class VectorStream {
   const bool useLosslessTimestamp_;
   const bool nullsFirst_;
   const bool isLongDecimal_;
+  const bool isUuid_;
   const SerdeOpts opts_;
   std::optional<VectorEncoding::Simple> encoding_;
   int32_t nonNullCount_{0};
@@ -1915,12 +1968,21 @@ FOLLY_ALWAYS_INLINE int128_t toJavaDecimalValue(int128_t value) {
   return value;
 }
 
+FOLLY_ALWAYS_INLINE int128_t toJavaUuidValue(int128_t value) {
+  // Presto Java UuidType expects 2 long values with MSB first.
+  // int128 will be serialized with [lower, upper], so swap here
+  // to adjust the order.
+  return DecimalUtil::bigEndian(value);
+}
+
 template <>
 void VectorStream::append(folly::Range<const int128_t*> values) {
   for (auto& value : values) {
     int128_t val = value;
     if (isLongDecimal_) {
       val = toJavaDecimalValue(value);
+    } else if (isUuid_) {
+      val = toJavaUuidValue(value);
     }
     values_.append<int128_t>(folly::Range(&val, 1));
   }
@@ -2595,6 +2657,14 @@ void appendNonNull(
           numNonNull,
           values,
           toJavaDecimalValue);
+    } else if (stream->isUuid()) {
+      copyWordsWithRows(
+          output,
+          rows.data(),
+          nonNullIndices,
+          numNonNull,
+          values,
+          toJavaUuidValue);
     } else {
       copyWordsWithRows(
           output, rows.data(), nonNullIndices, numNonNull, values);
@@ -2678,6 +2748,9 @@ void serializeFlatVector(
       if (stream->isLongDecimal()) {
         copyWords(
             output, rows.data(), rows.size(), rawValues, toJavaDecimalValue);
+      } else if (stream->isUuid()) {
+        copyWords(
+            output, rows.data(), rows.size(), rawValues, toJavaUuidValue);
       } else {
         copyWords(output, rows.data(), rows.size(), rawValues);
       }
diff --git a/velox/serializers/tests/PrestoSerializerTest.cpp b/velox/serializers/tests/PrestoSerializerTest.cpp
index ba1d3362720e9..49cdbdbef0f8f 100644
--- a/velox/serializers/tests/PrestoSerializerTest.cpp
+++ b/velox/serializers/tests/PrestoSerializerTest.cpp
@@ -16,6 +16,7 @@
 #include "velox/serializers/PrestoSerializer.h"
 #include <boost/random/uniform_int_distribution.hpp>
 #include <folly/Random.h>
+#include <functions/prestosql/types/UuidType.h>
 #include <gtest/gtest.h>
 #include <vector>
 #include "velox/common/base/tests/GTestUtils.h"
@@ -1149,6 +1150,19 @@ TEST_P(PrestoSerializerTest, longDecimal) {
   testRoundTrip(vector);
 }
 
+TEST_P(PrestoSerializerTest, uuid) {
+  auto vector = makeFlatVector<int128_t>(
+      200, [](vector_size_t row) { return (int128_t)0xD1 << row % 120; });
+
+  testRoundTrip(vector);
+
+  // Add some nulls.
+  for (auto i = 0; i < vector->size(); i += 7) {
+    vector->setNull(i, true);
+  }
+  testRoundTrip(vector);
+}
+
 // Test that hierarchically encoded columns (rows) have their encodings
 // preserved by the PrestoBatchVectorSerializer.
 TEST_P(PrestoSerializerTest, encodingsBatchVectorSerializer) {
diff --git a/velox/type/DecimalUtil.h b/velox/type/DecimalUtil.h
index dc935b94cdc95..0b91d21b02dae 100644
--- a/velox/type/DecimalUtil.h
+++ b/velox/type/DecimalUtil.h
@@ -479,6 +479,21 @@ class DecimalUtil {
   /// @return The length of out.
   static int32_t toByteArray(int128_t value, char* out);
 
+  /// Reverse byte order of an int128_t if native byte-order is little endian.
+  /// If native byte-order is big endian, the value will be unchanged. This
+  /// is similar to folly::Endian::big(), which does not support int128_t.
+  ///
+  /// \return A value with reversed byte-order for little endian platforms.
+  inline static int128_t bigEndian(int128_t value) {
+    if (folly::kIsLittleEndian) {
+      auto upper = folly::Endian::big(HugeInt::upper(value));
+      auto lower = folly::Endian::big(HugeInt::lower(value));
+      return HugeInt::build(lower, upper);
+    } else {
+      return value;
+    }
+  }
+
   static constexpr __uint128_t kOverflowMultiplier = ((__uint128_t)1 << 127);
 }; // DecimalUtil
 } // namespace facebook::velox