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Reason for changing parent term:
To better describe the current understanding of ECM components and compartments.
We propose to keep the extracellular matrix parent term currently referring to the metazoan ECM as the generic physiological "cellular compartment" based on GO's terminology. The extracellular matrix exists in three forms, each form is comprised of different molecules: the Interstitial matrix (GO:0005614), the Basement membrane (GO:0005604), and a compartment that is located at the interface of the interstitial matrix and the basement membrane.
Reference, in format PMID:
PMID: 39223427, PMID: 33605520
Add new terms as child terms
Add new child terms for Basement membrane (GO: 0005604)
To reflect the different compartments found within the two kinds of ECM. A big cluster of ECM phases, for better annotation and understanding of the ECM component.
Change parent term
The 4 direct child terms of extracellular matrix (GO:0031012) are:
Reason for changing parent term:
To better describe the current understanding of ECM components and compartments.
We propose to keep the extracellular matrix parent term currently referring to the metazoan ECM as the generic physiological "cellular compartment" based on GO's terminology. The extracellular matrix exists in three forms, each form is comprised of different molecules: the Interstitial matrix (GO:0005614), the Basement membrane (GO:0005604), and a compartment that is located at the interface of the interstitial matrix and the basement membrane.
Reference, in format PMID:
PMID: 39223427, PMID: 33605520
Add new terms as child terms
Add new child terms for Basement membrane (GO: 0005604)
Add new child term of Interstitial matrix (GO:0005614)
Reason for adding new terms
To reflect the different compartments found within the two kinds of ECM. A big cluster of ECM phases, for better annotation and understanding of the ECM component.
Other information
See slide 1: https://docs.google.com/presentation/d/1v4o53iJN2Ywo1qi3L8ANZg-p6uCSVaGi/edit?usp=sharing&ouid=109267399050361021326&rtpof=true&sd=true
Slide screenshot:
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