Textual definition update: GO:0008253 5'-nucleotidase activity

[ValWood]

• GO term ID and label for which you request a definition update

GO:0008253 5'-nucleotidase activity

• New proposed definition (genus-differentia pattern, plus additional information if needed)

Catalysis of the reaction: a 5'- ribo nucleotide + H2O = a ribo nucleoside + phosphate.

• Reference(s)
  PMID:nnnnnnn

• Additional information

[ValWood]

Actually I guess all the children are ribo, but in this case what happens with dNMP terms?

[deustp01]

but in this case what happens with dNMP terms?

Dunno. Maybe in the GO world as redefined, they are fated to remain eternally phosphorylated?

[raymond91125]

deoxy is of a separate branch.

[pgaudet]

Is the action to move GO:0002953 under GO:0008252 nucleotidase activity?

[ValWood]

I think you can do one of 2 things:

1. move GO:0002953 under GO:0008252
   and
   remove ribo from the definition of GO:0008252

OR

3. Keep ribo in the definition of GO:0008252 but update the label to 5' ribonucleotidase
   Catalysis of the reaction: a 5'- ribo nucleotide + H2O = a ribo nucleoside + phosphate.
   and create a common parent "5' nucleotidase activity" to GO:0002953 and GO:0008252

[raymond91125]

In the parlance of EC, nucleotidases are for ribonucleosides (EC:3.1.3.5/6/7) and apparently not for deoxyribonucleoside (EC:3.1.3.89).
GO:0008252 nucleotidase activity is however, for both as defined. I think it may be best to rename it to (deoxy)-nucleotidase activity. And then move GO:0002953 5'-deoxynucleotidase activity under it.

But then, GO:0008252 nucleotidase activity is defined by RHEA:22140 that has no direct annotations in UniProt. There are 9 direct EXP annotations to this term. I do wonder if all of them can be moved to a more specific term thus making it possible for GO:0008252 nucleotidase activity to become DO-NOT-ANNOTATE or even obsoleted.