diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index 48b9fb1d..3070cc33 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -257,7 +257,7 @@ jobs:
             "macos-13",
             "macos-latest",
           ]
-        python-version: ["3.9", "3.10", "3.11", "3.12", "3.13", "3.14"]
+        python-version: ["3.10", "3.11", "3.12", "3.13", "3.14"]
         include:
           - os: "ubuntu-latest"
             artifact: pyogrio-wheel-linux-manylinux2014_x86_64
diff --git a/CHANGES.md b/CHANGES.md
index e6702e2a..6d46eb05 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -23,6 +23,7 @@
 -   The GDAL library included in the wheels is upgraded from 3.10.3 to 3.11.4 (#578).
 -   Add libkml driver to the wheels for more recent Linux platforms supported
     by manylinux_2_28, MacOS, and Windows (#561).
+-   Add libspatialite to the wheels (#546).
 -   Wheels are now available for Python 3.14.
 
 ## 0.11.1 (2025-08-02)
diff --git a/ci/vcpkg-manylinux2014.json b/ci/vcpkg-manylinux2014.json
index c8b96c2e..a19b1381 100644
--- a/ci/vcpkg-manylinux2014.json
+++ b/ci/vcpkg-manylinux2014.json
@@ -2,10 +2,17 @@
     "name": "pyogrio",
     "version": "0.12.0",
     "dependencies": [
+        {
+            "name": "libspatialite",
+            "default-features": false,
+            "features": [
+                "rttopo"
+            ]
+        },
         {
             "name": "gdal",
             "default-features": false,
-            "features": ["recommended-features", "curl", "geos", "iconv", "openssl"]
+            "features": ["recommended-features", "curl", "geos", "iconv", "libspatialite", "openssl"]
         }
     ],
     "builtin-baseline": "da096fdc67db437bee863ae73c4c12e289f82789"
diff --git a/ci/vcpkg.json b/ci/vcpkg.json
index 41f5259d..7796dbb0 100644
--- a/ci/vcpkg.json
+++ b/ci/vcpkg.json
@@ -2,11 +2,18 @@
     "name": "pyogrio",
     "version": "0.12.0",
     "dependencies": [
+        {
+            "name": "libspatialite",
+            "default-features": false,
+            "features": [
+                "rttopo"
+            ]
+        },
         {
             "name": "gdal",
             "default-features": false,
             "features": [
-                "recommended-features", "curl", "geos", "iconv", "libkml", "openssl"
+                "recommended-features", "curl", "geos", "iconv", "libkml", "libspatialite", "openssl"
             ]
         }
     ],
diff --git a/pyogrio/tests/test_geopandas_io.py b/pyogrio/tests/test_geopandas_io.py
index e9a71aac..1ff9ff3f 100644
--- a/pyogrio/tests/test_geopandas_io.py
+++ b/pyogrio/tests/test_geopandas_io.py
@@ -106,14 +106,18 @@ def use_arrow_context():
         del os.environ["PYOGRIO_USE_ARROW"]
 
 
-def spatialite_available(path):
+@pytest.mark.skipif(
+    not GDAL_GE_350,
+    reason="GDAL Docker images with GDAL < 3.5 don't contain SpatiaLite",
+)
+def test_spatialite_available(test_gpkg_nulls):
+    """Check if SpatiaLite is available by running a simple SQL query."""
     try:
         _ = read_dataframe(
-            path, sql="select spatialite_version();", sql_dialect="SQLITE"
+            test_gpkg_nulls, sql="select spatialite_version();", sql_dialect="SQLITE"
         )
-        return True
-    except Exception:
-        return False
+    except Exception as ex:
+        raise AssertionError(f"SpatiaLite not available: {ex}")
 
 
 @pytest.mark.parametrize(