diff --git a/packages/node/src/integrations/http.ts b/packages/node/src/integrations/http.ts
index 151fa384b9f9..96f6c3f9dbd7 100644
--- a/packages/node/src/integrations/http.ts
+++ b/packages/node/src/integrations/http.ts
@@ -1,5 +1,5 @@
 import { getCurrentHub, Hub } from '@sentry/core';
-import { EventProcessor, Integration, Span, TracePropagationTargets } from '@sentry/types';
+import { EventProcessor, Integration, Span } from '@sentry/types';
 import {
   dynamicSamplingContextToSentryBaggageHeader,
   fill,
@@ -10,6 +10,7 @@ import {
 import * as http from 'http';
 import * as https from 'https';
 
+import { NodeClient } from '../client';
 import { NodeClientOptions } from '../types';
 import {
   cleanSpanDescription,
@@ -67,13 +68,8 @@ export class Http implements Integration {
       return;
     }
 
-    const clientOptions = setupOnceGetCurrentHub().getClient()?.getOptions() as NodeClientOptions | undefined;
-
-    const wrappedHandlerMaker = _createWrappedRequestMethodFactory(
-      this._breadcrumbs,
-      this._tracing,
-      clientOptions?.tracePropagationTargets,
-    );
+    const clientOptions = setupOnceGetCurrentHub().getClient<NodeClient>()?.getOptions();
+    const wrappedHandlerMaker = _createWrappedRequestMethodFactory(this._breadcrumbs, this._tracing, clientOptions);
 
     // eslint-disable-next-line @typescript-eslint/no-var-requires
     const httpModule = require('http');
@@ -109,24 +105,40 @@ type WrappedRequestMethodFactory = (original: OriginalRequestMethod) => WrappedR
 function _createWrappedRequestMethodFactory(
   breadcrumbsEnabled: boolean,
   tracingEnabled: boolean,
-  tracePropagationTargets: TracePropagationTargets | undefined,
+  options: NodeClientOptions | undefined,
 ): WrappedRequestMethodFactory {
-  // We're caching results so we dont have to recompute regexp everytime we create a request.
-  const urlMap: Record<string, boolean> = {};
+  // We're caching results so we don't have to recompute regexp every time we create a request.
+  const createSpanUrlMap: Record<string, boolean> = {};
+  const headersUrlMap: Record<string, boolean> = {};
+
+  const shouldCreateSpan = (url: string): boolean => {
+    if (options?.shouldCreateSpanForRequest === undefined) {
+      return true;
+    }
+
+    if (createSpanUrlMap[url]) {
+      return createSpanUrlMap[url];
+    }
+
+    createSpanUrlMap[url] = options.shouldCreateSpanForRequest(url);
+
+    return createSpanUrlMap[url];
+  };
+
   const shouldAttachTraceData = (url: string): boolean => {
-    if (tracePropagationTargets === undefined) {
+    if (options?.tracePropagationTargets === undefined) {
       return true;
     }
 
-    if (urlMap[url]) {
-      return urlMap[url];
+    if (headersUrlMap[url]) {
+      return headersUrlMap[url];
     }
 
-    urlMap[url] = tracePropagationTargets.some(tracePropagationTarget =>
+    headersUrlMap[url] = options.tracePropagationTargets.some(tracePropagationTarget =>
       isMatchingPattern(url, tracePropagationTarget),
     );
 
-    return urlMap[url];
+    return headersUrlMap[url];
   };
 
   return function wrappedRequestMethodFactory(originalRequestMethod: OriginalRequestMethod): WrappedRequestMethod {
@@ -148,7 +160,7 @@ function _createWrappedRequestMethodFactory(
 
       const scope = getCurrentHub().getScope();
 
-      if (scope && tracingEnabled) {
+      if (scope && tracingEnabled && shouldCreateSpan(requestUrl)) {
         parentSpan = scope.getSpan();
 
         if (parentSpan) {
diff --git a/packages/node/src/types.ts b/packages/node/src/types.ts
index 4d890d8e10b8..59c4c9af7ec7 100644
--- a/packages/node/src/types.ts
+++ b/packages/node/src/types.ts
@@ -19,6 +19,12 @@ export interface BaseNodeOptions {
    */
   tracePropagationTargets?: TracePropagationTargets;
 
+  /**
+   * Function determining whether or not to create spans to track outgoing requests to the given URL.
+   * By default, spans will be created for all outgoing requests.
+   */
+  shouldCreateSpanForRequest?(url: string): boolean;
+
   /** Callback that is executed when a fatal global error occurs. */
   onFatalError?(error: Error): void;
 }
diff --git a/packages/node/test/integrations/http.test.ts b/packages/node/test/integrations/http.test.ts
index 94bc4edf6c30..4f5205f0b596 100644
--- a/packages/node/test/integrations/http.test.ts
+++ b/packages/node/test/integrations/http.test.ts
@@ -221,8 +221,36 @@ describe('tracing', () => {
       addExtensionMethods();
       const transaction = hub.startTransaction({ name: 'dogpark' });
       hub.getScope()?.setSpan(transaction);
+      return transaction;
     }
 
+    it("doesn't create span if shouldCreateSpanForRequest returns false", () => {
+      const url = 'http://dogs.are.great/api/v1/index/';
+      nock(url).get(/.*/).reply(200);
+
+      const httpIntegration = new HttpIntegration({ tracing: true });
+
+      const hub = createHub({ shouldCreateSpanForRequest: () => false });
+
+      httpIntegration.setupOnce(
+        () => undefined,
+        () => hub,
+      );
+
+      const transaction = createTransactionAndPutOnScope(hub);
+      const spans = (transaction as unknown as Span).spanRecorder?.spans as Span[];
+
+      const request = http.get(url);
+
+      // There should be no http spans
+      const httpSpans = spans.filter(span => span.op?.startsWith('http'));
+      expect(httpSpans.length).toBe(0);
+
+      // And headers are not attached without span creation
+      expect(request.getHeader('sentry-trace')).toBeUndefined();
+      expect(request.getHeader('baggage')).toBeUndefined();
+    });
+
     it.each([
       ['http://dogs.are.great/api/v1/index/', [/.*/]],
       ['http://dogs.are.great/api/v1/index/', [/\/api/]],