diff --git a/packages/browser-integration-tests/suites/replay/slowClick/template.html b/packages/browser-integration-tests/suites/replay/slowClick/template.html
index f49c8b1d410d..83bda10053d1 100644
--- a/packages/browser-integration-tests/suites/replay/slowClick/template.html
+++ b/packages/browser-integration-tests/suites/replay/slowClick/template.html
@@ -19,6 +19,7 @@
     <button id="scrollLateButton">Trigger scroll late</button>
     <button id="mutationIgnoreButton" class="ignore-class">Trigger scroll late</button>
     <button id="mouseDownButton">Trigger mutation on mouse down</button>
+    <button id="windowOpenButton">Window open</button>
 
     <a href="#" id="link">Link</a>
     <a href="#" target="_blank" id="linkExternal">Link external</a>
@@ -73,6 +74,9 @@ <h1 id="h2">Bottom</h1>
       document.getElementById('mouseDownButton').addEventListener('mousedown', () => {
         document.getElementById('out').innerHTML += 'mutationButton clicked<br>';
       });
+      document.getElementById('windowOpenButton').addEventListener('click', () => {
+        window.open('https://example.com/', '_self');
+      });
 
       // Do nothing on these elements
       document
diff --git a/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts b/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts
new file mode 100644
index 000000000000..04dc4bb745e7
--- /dev/null
+++ b/packages/browser-integration-tests/suites/replay/slowClick/windowOpen/test.ts
@@ -0,0 +1,61 @@
+import { expect } from '@playwright/test';
+
+import { sentryTest } from '../../../../utils/fixtures';
+import { getCustomRecordingEvents, shouldSkipReplayTest, waitForReplayRequest } from '../../../../utils/replayHelpers';
+
+sentryTest('window.open() is considered for slow click', async ({ getLocalTestUrl, page }) => {
+  if (shouldSkipReplayTest()) {
+    sentryTest.skip();
+  }
+
+  const reqPromise0 = waitForReplayRequest(page, 0);
+
+  await page.route('https://dsn.ingest.sentry.io/**/*', route => {
+    return route.fulfill({
+      status: 200,
+      contentType: 'application/json',
+      body: JSON.stringify({ id: 'test-id' }),
+    });
+  });
+
+  const url = await getLocalTestUrl({ testDir: __dirname });
+
+  await page.goto(url);
+  await reqPromise0;
+
+  const reqPromise1 = waitForReplayRequest(page, (event, res) => {
+    const { breadcrumbs } = getCustomRecordingEvents(res);
+
+    return breadcrumbs.some(breadcrumb => breadcrumb.category === 'ui.click');
+  });
+
+  await page.click('#windowOpenButton');
+  const navPromise = page.waitForURL('https://example.com/');
+
+  const { breadcrumbs } = getCustomRecordingEvents(await reqPromise1);
+
+  expect(breadcrumbs).toEqual([
+    {
+      category: 'ui.click',
+      data: {
+        node: {
+          attributes: {
+            id: 'windowOpenButton',
+          },
+          id: expect.any(Number),
+          tagName: 'button',
+          textContent: '****** ****',
+        },
+        nodeId: expect.any(Number),
+      },
+      message: 'body > button#windowOpenButton',
+      timestamp: expect.any(Number),
+      type: 'default',
+    },
+  ]);
+
+  await navPromise;
+
+  // Ensure window.open() still works as expected
+  expect(await page.url()).toBe('https://example.com/');
+});
diff --git a/packages/replay/src/coreHandlers/handleClick.ts b/packages/replay/src/coreHandlers/handleClick.ts
index 5a75413b00d1..c5a65ddfdca0 100644
--- a/packages/replay/src/coreHandlers/handleClick.ts
+++ b/packages/replay/src/coreHandlers/handleClick.ts
@@ -4,6 +4,7 @@ import { WINDOW } from '../constants';
 import type { MultiClickFrame, ReplayClickDetector, ReplayContainer, SlowClickConfig, SlowClickFrame } from '../types';
 import { addBreadcrumbEvent } from './util/addBreadcrumbEvent';
 import { getClickTargetNode } from './util/domUtils';
+import { onWindowOpen } from './util/onWindowOpen';
 
 type ClickBreadcrumb = Breadcrumb & {
   timestamp: number;
@@ -68,6 +69,11 @@ export class ClickDetector implements ReplayClickDetector {
       this._lastScroll = nowInSeconds();
     };
 
+    const cleanupWindowOpen = onWindowOpen(() => {
+      // Treat window.open as mutation
+      this._lastMutation = nowInSeconds();
+    });
+
     const clickHandler = (event: MouseEvent): void => {
       if (!event.target) {
         return;
@@ -94,6 +100,7 @@ export class ClickDetector implements ReplayClickDetector {
     this._teardown = () => {
       WINDOW.removeEventListener('scroll', scrollHandler);
       WINDOW.removeEventListener('click', clickHandler);
+      cleanupWindowOpen();
 
       obs.disconnect();
       this._clicks = [];
diff --git a/packages/replay/src/coreHandlers/util/onWindowOpen.ts b/packages/replay/src/coreHandlers/util/onWindowOpen.ts
new file mode 100644
index 000000000000..e3b6b7ac92ed
--- /dev/null
+++ b/packages/replay/src/coreHandlers/util/onWindowOpen.ts
@@ -0,0 +1,44 @@
+import { fill } from '@sentry/utils';
+
+import { WINDOW } from '../../constants';
+
+type WindowOpenHandler = () => void;
+
+let handlers: undefined | WindowOpenHandler[];
+
+/**
+ * Register a handler to be called when `window.open()` is called.
+ * Returns a cleanup function.
+ */
+export function onWindowOpen(cb: WindowOpenHandler): () => void {
+  // Ensure to only register this once
+  if (!handlers) {
+    handlers = [];
+    monkeyPatchWindowOpen();
+  }
+
+  handlers.push(cb);
+
+  return () => {
+    const pos = handlers ? handlers.indexOf(cb) : -1;
+    if (pos > -1) {
+      (handlers as WindowOpenHandler[]).splice(pos, 1);
+    }
+  };
+}
+
+function monkeyPatchWindowOpen(): void {
+  fill(WINDOW, 'open', function (originalWindowOpen: () => void): () => void {
+    return function (...args: unknown[]): void {
+      if (handlers) {
+        try {
+          handlers.forEach(handler => handler());
+        } catch (e) {
+          // ignore errors in here
+        }
+      }
+
+      return originalWindowOpen.apply(WINDOW, args);
+    };
+  });
+}