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-name: Patrick Sung, D.Phil
-positions:
-  - Univ. of Texas Health Science Center at San Antonio
-associations:
-  - "Lab: [Sung Lab](https://campaigns.uthscsa.edu/lab-sung/)"
-  - "Project: [Dissection of BRCA-mediated Tumor Suppression Pathways](projects#dissection-of-brca-mediated-tumor-suppression-pathways)"
-
-photo: people/sung-patrick.jpg
-
-group: principals
-
-weight: 10
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-title: Dissection of BRCA-mediated Tumor Suppression Pathways
-project_lead: Patrick Sung, D.Phil
-team: D’Andrea, Chowdhury, Greenberg
-research_questions:
-  - What are the regulators of BRCA function?
-  - What are BRCA-independent DNA repair pathways?
-  - What are the DNA repair mechanisms?
-  - What are the drug vulnerabilities of BRCA deficient cells?
-
-related_publications:
-  - "Zhao W, Wiese C, Kwon Y, Hromas R, Sung P. The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination. Annu Rev Biochem. 2019 Jun 20;88:221-245. doi: [10.1146/annurev-biochem-013118-111058](https://www.doi.org/10.1146/annurev-biochem-013118-111058). Epub 2019 Mar 27. PMID: [30917004](https://pubmed.ncbi.nlm.nih.gov/30917004); PMCID: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004434]."
-  - "Tarsounas M, Sung P. The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication. Nat Rev Mol Cell Biol. 2020 May;21(5):284-299. doi: [10.1038/s41580-020-0218-z](https://www.doi.org/10.1038/s41580-020-0218-z). Epub 2020 Feb 24. PMID: [32094664](https://pubmed.ncbi.nlm.nih.gov/32094664); PMCID: PMC7204409."
-
-weight: 50
----
-The goal of this project is to better understand how BRCA-mediated defects in DNA repair mechanisms give rise to cancer and later to resistance to standard therapy. BRCA1 and BRCA2 are part of a complex network of DNA damage checkpoints and repair pathways that has evolved to minimize the harm causes by environmental agents (e.g. high energy radiation) and reactive metabolites (e.g. aldehydes and free radicals) that damage DNA. Disruption of this network can leads genome instability and disease, especially cancer. g how the BRCA tumor suppressor network executes its biological functions could provide the foundation for developing targeted cancer therapeutics. Dr. Patrick Sung is leveraging new advances in BRCA protein purification to carry out mechanistic studies of BRCA pathways that elucidate the biochemical attributes of these complexes and the multi-faceted roles that they fulfill in genome maintenance.