00-Download OTG study and V2G Info.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "%load_ext autoreload\n",
    "%autoreload 2"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Download OTG 210608 L2G mappings"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "import gc\n",
    "import json\n",
    "import time\n",
    "from ftplib import FTP\n",
    "from pathlib import Path\n",
    "from urllib.request import urlopen\n",
    "\n",
    "import numpy as np\n",
    "import scipy as sp\n",
    "import scipy.sparse as spp\n",
    "import scanpy as sc\n",
    "\n",
    "from tqdm.auto import tqdm\n",
    "import pandas as pd\n",
    "from pandas import json_normalize\n",
    "import matplotlib.pyplot as plt\n",
    "\n",
    "from pyannotables import tables"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "import genetics"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "pd.set_option('display.max_columns', None)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Fetch study JSON files from FTP"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "url_root = 'ftp.ebi.ac.uk'\n",
    "json_dir = '/pub/databases/opentargets/genetics/210608/lut/study-index'\n",
    "\n",
    "ftp = FTP(url_root)\n",
    "ftp.login()\n",
    "ftp.cwd(json_dir)\n",
    "\n",
    "files = []\n",
    "cb = lambda x: files.append(x.split()[8]) if \"SUCCESS\" not in x else None\n",
    "\n",
    "code = ftp.retrlines('LIST', callback=cb)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['part-00000-7e851255-3224-4792-8c77-5ad68c417102-c000.json',\n",
       " 'part-00001-7e851255-3224-4792-8c77-5ad68c417102-c000.json',\n",
       " 'part-00002-7e851255-3224-4792-8c77-5ad68c417102-c000.json',\n",
       " 'part-00003-7e851255-3224-4792-8c77-5ad68c417102-c000.json',\n",
       " 'part-00004-7e851255-3224-4792-8c77-5ad68c417102-c000.json']"
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "files[:5]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Parse study JSON files"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "73b4e317fc8d4af2953646cf853b8668",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/57 [00:00<?, ?it/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "studies = []\n",
    "\n",
    "for f in tqdm(files):\n",
    "\n",
    "    file_url = f'ftp://{url_root}{json_dir}/{f}'\n",
    "    json_url = urlopen(file_url, timeout=10)\n",
    "    df = json_normalize([json.loads(x.decode('utf-8')) for x in json_url.readlines()])\n",
    "    studies.append(df)\n",
    "    \n",
    "studies = pd.concat(studies, axis=0).reset_index(drop=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(33781, 17)"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "studies.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(17054, 17)"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "studies = studies[studies.num_assoc_loci>0]\n",
    "studies.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>study_id</th>\n",
       "      <th>pub_date</th>\n",
       "      <th>pub_author</th>\n",
       "      <th>trait_reported</th>\n",
       "      <th>ancestry_initial</th>\n",
       "      <th>ancestry_replication</th>\n",
       "      <th>n_initial</th>\n",
       "      <th>n_replication</th>\n",
       "      <th>n_cases</th>\n",
       "      <th>num_assoc_loci</th>\n",
       "      <th>has_sumstats</th>\n",
       "      <th>source</th>\n",
       "      <th>trait_efos</th>\n",
       "      <th>trait_category</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pub_journal</th>\n",
       "      <th>pub_title</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>FINNGEN_R5_AB1_BACTINF_NOS</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>\"Bacterial infection, other or unspecified\"</td>\n",
       "      <td>[European=218637]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218637</td>\n",
       "      <td>0.0</td>\n",
       "      <td>20977.0</td>\n",
       "      <td>2</td>\n",
       "      <td>True</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0000771]</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>FINNGEN_R5_AB1_DERMATOPHYTOSIS</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>Dermatophytosis</td>\n",
       "      <td>[European=216472]</td>\n",
       "      <td>[]</td>\n",
       "      <td>216472</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1656.0</td>\n",
       "      <td>1</td>\n",
       "      <td>True</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0004678]</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>FINNGEN_R5_AB1_EBV</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>Infectious mononucleosis</td>\n",
       "      <td>[European=214904]</td>\n",
       "      <td>[]</td>\n",
       "      <td>214904</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1238.0</td>\n",
       "      <td>1</td>\n",
       "      <td>True</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0007326]</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>FINNGEN_R5_AB1_GASTROENTERITIS_NOS</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>Diarrhoea and gastroenteritis of presumed infe...</td>\n",
       "      <td>[European=212553]</td>\n",
       "      <td>[]</td>\n",
       "      <td>212553</td>\n",
       "      <td>0.0</td>\n",
       "      <td>15255.0</td>\n",
       "      <td>1</td>\n",
       "      <td>True</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0045031]</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>FINNGEN_R5_AB1_GHLAMY_OTHER</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>Other diseases caused by chlamydiae</td>\n",
       "      <td>[European=218772]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218772</td>\n",
       "      <td>0.0</td>\n",
       "      <td>167.0</td>\n",
       "      <td>1</td>\n",
       "      <td>True</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_1001288]</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                              study_id    pub_date  pub_author  \\\n",
       "5           FINNGEN_R5_AB1_BACTINF_NOS  2021-05-11  FINNGEN_R5   \n",
       "12      FINNGEN_R5_AB1_DERMATOPHYTOSIS  2021-05-11  FINNGEN_R5   \n",
       "14                  FINNGEN_R5_AB1_EBV  2021-05-11  FINNGEN_R5   \n",
       "16  FINNGEN_R5_AB1_GASTROENTERITIS_NOS  2021-05-11  FINNGEN_R5   \n",
       "17         FINNGEN_R5_AB1_GHLAMY_OTHER  2021-05-11  FINNGEN_R5   \n",
       "\n",
       "                                       trait_reported   ancestry_initial  \\\n",
       "5         \"Bacterial infection, other or unspecified\"  [European=218637]   \n",
       "12                                    Dermatophytosis  [European=216472]   \n",
       "14                           Infectious mononucleosis  [European=214904]   \n",
       "16  Diarrhoea and gastroenteritis of presumed infe...  [European=212553]   \n",
       "17                Other diseases caused by chlamydiae  [European=218772]   \n",
       "\n",
       "   ancestry_replication  n_initial  n_replication  n_cases  num_assoc_loci  \\\n",
       "5                    []     218637            0.0  20977.0               2   \n",
       "12                   []     216472            0.0   1656.0               1   \n",
       "14                   []     214904            0.0   1238.0               1   \n",
       "16                   []     212553            0.0  15255.0               1   \n",
       "17                   []     218772            0.0    167.0               1   \n",
       "\n",
       "    has_sumstats   source       trait_efos      trait_category pmid  \\\n",
       "5           True  FINNGEN    [EFO_0000771]  infectious disease  NaN   \n",
       "12          True  FINNGEN  [MONDO_0004678]  infectious disease  NaN   \n",
       "14          True  FINNGEN    [EFO_0007326]  infectious disease  NaN   \n",
       "16          True  FINNGEN  [MONDO_0045031]  infectious disease  NaN   \n",
       "17          True  FINNGEN    [EFO_1001288]  infectious disease  NaN   \n",
       "\n",
       "   pub_journal pub_title  \n",
       "5          NaN       NaN  \n",
       "12         NaN       NaN  \n",
       "14         NaN       NaN  \n",
       "16         NaN       NaN  \n",
       "17         NaN       NaN  "
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "studies.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "14384"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "studies.trait_reported.nunique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "3925"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "studies.trait_efos.astype(str).nunique()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Fetch study and variant info through GraphQL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [],
   "source": [
    "all_studies = sorted(list(set(studies.study_id.tolist())))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "17054"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(all_studies)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [],
   "source": [
    "chunk_size = 10\n",
    "split_studies = np.array_split(all_studies, len(all_studies)//chunk_size)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [],
   "source": [
    "api = genetics.Genetics()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "11"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(split_studies[0])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'FINNGEN_R5_AB1_BACTINF_NOS'"
      ]
     },
     "execution_count": 18,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "split_studies[0][0]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>studyId</th>\n",
       "      <th>traitReported</th>\n",
       "      <th>source</th>\n",
       "      <th>traitEfos</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pubDate</th>\n",
       "      <th>pubJournal</th>\n",
       "      <th>pubTitle</th>\n",
       "      <th>pubAuthor</th>\n",
       "      <th>hasSumstats</th>\n",
       "      <th>ancestryInitial</th>\n",
       "      <th>ancestryReplication</th>\n",
       "      <th>nInitial</th>\n",
       "      <th>nReplication</th>\n",
       "      <th>nCases</th>\n",
       "      <th>traitCategory</th>\n",
       "      <th>numAssocLoci</th>\n",
       "      <th>nTotal</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>FINNGEN_R5_AB1_BACTINF_NOS</td>\n",
       "      <td>\"Bacterial infection, other or unspecified\"</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0000771]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218637]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218637</td>\n",
       "      <td>0</td>\n",
       "      <td>20977</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>2</td>\n",
       "      <td>218637</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                      studyId                                traitReported  \\\n",
       "0  FINNGEN_R5_AB1_BACTINF_NOS  \"Bacterial infection, other or unspecified\"   \n",
       "\n",
       "    source      traitEfos  pmid     pubDate pubJournal pubTitle   pubAuthor  \\\n",
       "0  FINNGEN  [EFO_0000771]  None  2021-05-11       None     None  FINNGEN_R5   \n",
       "\n",
       "   hasSumstats    ancestryInitial ancestryReplication  nInitial  nReplication  \\\n",
       "0         True  [European=218637]                  []    218637             0   \n",
       "\n",
       "   nCases       traitCategory  numAssocLoci  nTotal  \n",
       "0   20977  infectious disease             2  218637  "
      ]
     },
     "execution_count": 19,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "api.study_info([split_studies[0][0]])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array(['FINNGEN_R5_AB1_BACTINF_NOS', 'FINNGEN_R5_AB1_DERMATOPHYTOSIS',\n",
       "       'FINNGEN_R5_AB1_EBV', 'FINNGEN_R5_AB1_GASTROENTERITIS_NOS',\n",
       "       'FINNGEN_R5_AB1_GHLAMY_OTHER', 'FINNGEN_R5_AB1_MALARIA',\n",
       "       'FINNGEN_R5_AB1_MEASLES', 'FINNGEN_R5_AB1_OTHER_BACTERIAL',\n",
       "       'FINNGEN_R5_AB1_OTHER_CHLAMYDIAE',\n",
       "       'FINNGEN_R5_AB1_OTHER_SPIROCHAETAL'], dtype='<U113')"
      ]
     },
     "execution_count": 20,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "split_studies[0][:10]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>bestGenes</th>\n",
       "      <th>bestColocGenes</th>\n",
       "      <th>bestLocus2Genes</th>\n",
       "      <th>pvalMantissa</th>\n",
       "      <th>pvalExponent</th>\n",
       "      <th>credibleSetSize</th>\n",
       "      <th>ldSetSize</th>\n",
       "      <th>totalSetSize</th>\n",
       "      <th>pval</th>\n",
       "      <th>oddsRatio</th>\n",
       "      <th>oddsRatioCILower</th>\n",
       "      <th>oddsRatioCIUpper</th>\n",
       "      <th>beta</th>\n",
       "      <th>betaCILower</th>\n",
       "      <th>betaCIUpper</th>\n",
       "      <th>direction</th>\n",
       "      <th>variant_chromosome</th>\n",
       "      <th>variant_position</th>\n",
       "      <th>variant_refAllele</th>\n",
       "      <th>variant_altAllele</th>\n",
       "      <th>variant_rsId</th>\n",
       "      <th>variant_chromosomeB37</th>\n",
       "      <th>variant_positionB37</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_nearestGene_id</th>\n",
       "      <th>variant_nearestGene_symbol</th>\n",
       "      <th>variant_nearestGene_bioType</th>\n",
       "      <th>variant_nearestGene_description</th>\n",
       "      <th>variant_nearestGene_chromosome</th>\n",
       "      <th>variant_nearestGene_tss</th>\n",
       "      <th>variant_nearestGene_start</th>\n",
       "      <th>variant_nearestGene_end</th>\n",
       "      <th>variant_nearestGene_fwdStrand</th>\n",
       "      <th>variant_nearestGene_exons</th>\n",
       "      <th>variant_nearestGeneDistance</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>variant_nearestCodingGene_bioType</th>\n",
       "      <th>variant_nearestCodingGene_description</th>\n",
       "      <th>variant_nearestCodingGene_chromosome</th>\n",
       "      <th>variant_nearestCodingGene_tss</th>\n",
       "      <th>variant_nearestCodingGene_start</th>\n",
       "      <th>variant_nearestCodingGene_end</th>\n",
       "      <th>variant_nearestCodingGene_fwdStrand</th>\n",
       "      <th>variant_nearestCodingGene_exons</th>\n",
       "      <th>variant_nearestCodingGeneDistance</th>\n",
       "      <th>variant_mostSevereConsequence</th>\n",
       "      <th>variant_caddRaw</th>\n",
       "      <th>variant_caddPhred</th>\n",
       "      <th>variant_gnomadAFR</th>\n",
       "      <th>variant_gnomadAMR</th>\n",
       "      <th>variant_gnomadASJ</th>\n",
       "      <th>variant_gnomadEAS</th>\n",
       "      <th>variant_gnomadFIN</th>\n",
       "      <th>variant_gnomadNFE</th>\n",
       "      <th>variant_gnomadNFEEST</th>\n",
       "      <th>variant_gnomadNFENWE</th>\n",
       "      <th>variant_gnomadNFESEU</th>\n",
       "      <th>variant_gnomadNFEONF</th>\n",
       "      <th>variant_gnomadOTH</th>\n",
       "      <th>study</th>\n",
       "      <th>variant_nearestGene</th>\n",
       "      <th>variant_nearestCodingGene</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>7.347</td>\n",
       "      <td>-10</td>\n",
       "      <td>3</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>7.347000e-10</td>\n",
       "      <td>8.750275e-01</td>\n",
       "      <td>8.386280e-01</td>\n",
       "      <td>9.130068e-01</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>159743672</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs74596724</td>\n",
       "      <td>1</td>\n",
       "      <td>159713462</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>29083</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>29083</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.770176</td>\n",
       "      <td>11.64</td>\n",
       "      <td>0.011703</td>\n",
       "      <td>0.040094</td>\n",
       "      <td>0.096552</td>\n",
       "      <td>0.164103</td>\n",
       "      <td>0.063364</td>\n",
       "      <td>0.075765</td>\n",
       "      <td>0.096288</td>\n",
       "      <td>0.067939</td>\n",
       "      <td>0.09434</td>\n",
       "      <td>0.062324</td>\n",
       "      <td>0.0625</td>\n",
       "      <td>FINNGEN_R5_AB1_BACTINF_NOS</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000235532', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000118922', 'symbol': ...</td>\n",
       "      <td>4.621</td>\n",
       "      <td>-8</td>\n",
       "      <td>8</td>\n",
       "      <td>0</td>\n",
       "      <td>8</td>\n",
       "      <td>4.621000e-08</td>\n",
       "      <td>1.994114e+00</td>\n",
       "      <td>1.556870e+00</td>\n",
       "      <td>2.554158e+00</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>13</td>\n",
       "      <td>74291635</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117832616</td>\n",
       "      <td>13</td>\n",
       "      <td>74865772</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>ENSG00000235532</td>\n",
       "      <td>LINC00402</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 402 [So...</td>\n",
       "      <td>13</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74259976.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[74256933, 74259976, 74231457, 74231752]</td>\n",
       "      <td>60178</td>\n",
       "      <td>ENSG00000118922</td>\n",
       "      <td>KLF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Kruppel like factor 12 [Source:HGNC Symbol;Acc...</td>\n",
       "      <td>13</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>73686089.0</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[73686089, 73695671, 73715368, 73715525, 73764...</td>\n",
       "      <td>296579</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.24534</td>\n",
       "      <td>0.528</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002358</td>\n",
       "      <td>0</td>\n",
       "      <td>0.010296</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.000519</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000935</td>\n",
       "      <td>0</td>\n",
       "      <td>FINNGEN_R5_AB1_BACTINF_NOS</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000135336', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000118434', 'symbol': ...</td>\n",
       "      <td>1.263</td>\n",
       "      <td>-8</td>\n",
       "      <td>27</td>\n",
       "      <td>60</td>\n",
       "      <td>63</td>\n",
       "      <td>1.263000e-08</td>\n",
       "      <td>1.350399e+00</td>\n",
       "      <td>1.217672e+00</td>\n",
       "      <td>1.497592e+00</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>87971973</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>rs2474884</td>\n",
       "      <td>6</td>\n",
       "      <td>88681691</td>\n",
       "      <td>6_87971973_T_C</td>\n",
       "      <td>ENSG00000118434</td>\n",
       "      <td>SPACA1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>sperm acrosome associated 1 [Source:HGNC Symbo...</td>\n",
       "      <td>6</td>\n",
       "      <td>88047841.0</td>\n",
       "      <td>88047841.0</td>\n",
       "      <td>88066838.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[88066182, 88066838, 88064099, 88064219, 88059...</td>\n",
       "      <td>75868</td>\n",
       "      <td>ENSG00000118434</td>\n",
       "      <td>SPACA1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>sperm acrosome associated 1 [Source:HGNC Symbo...</td>\n",
       "      <td>6</td>\n",
       "      <td>88047841.0</td>\n",
       "      <td>88047841.0</td>\n",
       "      <td>88066838.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[88066182, 88066838, 88064099, 88064219, 88059...</td>\n",
       "      <td>75868</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.263616</td>\n",
       "      <td>6.735</td>\n",
       "      <td>0.432896</td>\n",
       "      <td>0.116745</td>\n",
       "      <td>0.177083</td>\n",
       "      <td>0.120513</td>\n",
       "      <td>0.122984</td>\n",
       "      <td>0.15179</td>\n",
       "      <td>0.16027</td>\n",
       "      <td>0.150675</td>\n",
       "      <td>0.150943</td>\n",
       "      <td>0.138109</td>\n",
       "      <td>0.168199</td>\n",
       "      <td>FINNGEN_R5_AB1_DERMATOPHYTOSIS</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000234225', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000268043', 'symbol': ...</td>\n",
       "      <td>2.788</td>\n",
       "      <td>-8</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>2.788000e-08</td>\n",
       "      <td>7.198589e-01</td>\n",
       "      <td>6.410213e-01</td>\n",
       "      <td>8.083926e-01</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>147027146</td>\n",
       "      <td>G</td>\n",
       "      <td>A</td>\n",
       "      <td>rs11587105</td>\n",
       "      <td>1</td>\n",
       "      <td>146498703</td>\n",
       "      <td>1_147027146_G_A</td>\n",
       "      <td>ENSG00000234225</td>\n",
       "      <td>AC244394.2</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>novel transcript</td>\n",
       "      <td>1</td>\n",
       "      <td>147003618.0</td>\n",
       "      <td>147001931.0</td>\n",
       "      <td>147003618.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[147001931, 147002332, 147002897, 147003191, 1...</td>\n",
       "      <td>23528</td>\n",
       "      <td>ENSG00000268043</td>\n",
       "      <td>NBPF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>NBPF member 12 [Source:HGNC Symbol;Acc:HGNC:24...</td>\n",
       "      <td>1</td>\n",
       "      <td>146938744.0</td>\n",
       "      <td>146938744.0</td>\n",
       "      <td>146996202.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[146987954, 146988126, 146987234, 146987285, 1...</td>\n",
       "      <td>88402</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>-0.260592</td>\n",
       "      <td>0.476</td>\n",
       "      <td>0.168334</td>\n",
       "      <td>0.15566</td>\n",
       "      <td>0.248276</td>\n",
       "      <td>0.107742</td>\n",
       "      <td>0.142607</td>\n",
       "      <td>0.243909</td>\n",
       "      <td>0.171875</td>\n",
       "      <td>0.278828</td>\n",
       "      <td>0.264151</td>\n",
       "      <td>0.256098</td>\n",
       "      <td>0.185874</td>\n",
       "      <td>FINNGEN_R5_AB1_EBV</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000263443', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000178764', 'symbol': ...</td>\n",
       "      <td>2.100</td>\n",
       "      <td>-8</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>2.100000e-08</td>\n",
       "      <td>1.351209e+00</td>\n",
       "      <td>1.216182e+00</td>\n",
       "      <td>1.501228e+00</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>8</td>\n",
       "      <td>122593984</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117622394</td>\n",
       "      <td>8</td>\n",
       "      <td>123606223</td>\n",
       "      <td>8_122593984_C_T</td>\n",
       "      <td>ENSG00000253819</td>\n",
       "      <td>LINC01151</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 1151 [S...</td>\n",
       "      <td>8</td>\n",
       "      <td>122694106.0</td>\n",
       "      <td>122670385.0</td>\n",
       "      <td>122694106.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[122670385, 122670500, 122671269, 122671388, 1...</td>\n",
       "      <td>100122</td>\n",
       "      <td>ENSG00000178764</td>\n",
       "      <td>ZHX2</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>zinc fingers and homeoboxes 2 [Source:HGNC Sym...</td>\n",
       "      <td>8</td>\n",
       "      <td>122781655.0</td>\n",
       "      <td>122781655.0</td>\n",
       "      <td>122974510.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[122973242, 122974510, 122951292, 122954028, 1...</td>\n",
       "      <td>187671</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.006131</td>\n",
       "      <td>2.717</td>\n",
       "      <td>0.002066</td>\n",
       "      <td>0.005896</td>\n",
       "      <td>0.024138</td>\n",
       "      <td>0</td>\n",
       "      <td>0.014113</td>\n",
       "      <td>0.014388</td>\n",
       "      <td>0.020897</td>\n",
       "      <td>0.011636</td>\n",
       "      <td>0</td>\n",
       "      <td>0.012172</td>\n",
       "      <td>0.01107</td>\n",
       "      <td>FINNGEN_R5_AB1_GASTROENTERITIS_NOS</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000112818', 'symbol': ...</td>\n",
       "      <td>2.015</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>2.015000e-08</td>\n",
       "      <td>7.938578e+09</td>\n",
       "      <td>2.763396e+06</td>\n",
       "      <td>2.280564e+13</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5_AB1_GHLAMY_OTHER</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>4.906</td>\n",
       "      <td>-8</td>\n",
       "      <td>13</td>\n",
       "      <td>0</td>\n",
       "      <td>13</td>\n",
       "      <td>4.906000e-08</td>\n",
       "      <td>1.988523e+33</td>\n",
       "      <td>2.155591e+21</td>\n",
       "      <td>1.834402e+45</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>7</td>\n",
       "      <td>72005814</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>7_72005814_T_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5_AB1_MALARIA</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000273396', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000163132', 'symbol': ...</td>\n",
       "      <td>4.990</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>13</td>\n",
       "      <td>13</td>\n",
       "      <td>4.990000e-08</td>\n",
       "      <td>5.525010e-01</td>\n",
       "      <td>4.463710e-01</td>\n",
       "      <td>6.838647e-01</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>4</td>\n",
       "      <td>4864861</td>\n",
       "      <td>A</td>\n",
       "      <td>C</td>\n",
       "      <td>rs6825765</td>\n",
       "      <td>4</td>\n",
       "      <td>4866588</td>\n",
       "      <td>4_4864861_A_C</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "      <td>5196</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "      <td>5196</td>\n",
       "      <td>downstream_gene_variant</td>\n",
       "      <td>0.129132</td>\n",
       "      <td>4.745</td>\n",
       "      <td>0.468369</td>\n",
       "      <td>0.612028</td>\n",
       "      <td>0.375862</td>\n",
       "      <td>0.652706</td>\n",
       "      <td>0.601729</td>\n",
       "      <td>0.464031</td>\n",
       "      <td>0.508534</td>\n",
       "      <td>0.448545</td>\n",
       "      <td>0.443396</td>\n",
       "      <td>0.432116</td>\n",
       "      <td>0.48893</td>\n",
       "      <td>FINNGEN_R5_AB1_MEASLES</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>6.133</td>\n",
       "      <td>-10</td>\n",
       "      <td>3</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>6.133000e-10</td>\n",
       "      <td>8.747650e-01</td>\n",
       "      <td>8.384610e-01</td>\n",
       "      <td>9.126409e-01</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>159743672</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs74596724</td>\n",
       "      <td>1</td>\n",
       "      <td>159713462</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>29083</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>29083</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.770176</td>\n",
       "      <td>11.64</td>\n",
       "      <td>0.011703</td>\n",
       "      <td>0.040094</td>\n",
       "      <td>0.096552</td>\n",
       "      <td>0.164103</td>\n",
       "      <td>0.063364</td>\n",
       "      <td>0.075765</td>\n",
       "      <td>0.096288</td>\n",
       "      <td>0.067939</td>\n",
       "      <td>0.09434</td>\n",
       "      <td>0.062324</td>\n",
       "      <td>0.0625</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000235532', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000118922', 'symbol': ...</td>\n",
       "      <td>4.023</td>\n",
       "      <td>-8</td>\n",
       "      <td>8</td>\n",
       "      <td>0</td>\n",
       "      <td>8</td>\n",
       "      <td>4.023000e-08</td>\n",
       "      <td>1.997507e+00</td>\n",
       "      <td>1.560296e+00</td>\n",
       "      <td>2.557230e+00</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>13</td>\n",
       "      <td>74291635</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117832616</td>\n",
       "      <td>13</td>\n",
       "      <td>74865772</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>ENSG00000235532</td>\n",
       "      <td>LINC00402</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 402 [So...</td>\n",
       "      <td>13</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74259976.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[74256933, 74259976, 74231457, 74231752]</td>\n",
       "      <td>60178</td>\n",
       "      <td>ENSG00000118922</td>\n",
       "      <td>KLF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Kruppel like factor 12 [Source:HGNC Symbol;Acc...</td>\n",
       "      <td>13</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>73686089.0</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[73686089, 73695671, 73715368, 73715525, 73764...</td>\n",
       "      <td>296579</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.24534</td>\n",
       "      <td>0.528</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002358</td>\n",
       "      <td>0</td>\n",
       "      <td>0.010296</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.000519</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000935</td>\n",
       "      <td>0</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000112818', 'symbol': ...</td>\n",
       "      <td>1.552</td>\n",
       "      <td>-9</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>1.552000e-09</td>\n",
       "      <td>2.013449e+10</td>\n",
       "      <td>9.112824e+06</td>\n",
       "      <td>4.448650e+13</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_CHLAMYDIAE</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000135316', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>4.612</td>\n",
       "      <td>-8</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>4.612000e-08</td>\n",
       "      <td>2.967738e+00</td>\n",
       "      <td>2.009148e+00</td>\n",
       "      <td>4.383682e+00</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>86087207</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>rs184239803</td>\n",
       "      <td>6</td>\n",
       "      <td>86796925</td>\n",
       "      <td>6_86087207_T_C</td>\n",
       "      <td>ENSG00000135316</td>\n",
       "      <td>SYNCRIP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>synaptotagmin binding cytoplasmic RNA interact...</td>\n",
       "      <td>6</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>85607785.0</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[85636967, 85637143, 85614106, 85615347, 85618...</td>\n",
       "      <td>443415</td>\n",
       "      <td>ENSG00000135316</td>\n",
       "      <td>SYNCRIP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>synaptotagmin binding cytoplasmic RNA interact...</td>\n",
       "      <td>6</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>85607785.0</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[85636967, 85637143, 85614106, 85615347, 85618...</td>\n",
       "      <td>443415</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.082352</td>\n",
       "      <td>1.574</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.016983</td>\n",
       "      <td>0.003953</td>\n",
       "      <td>0.010235</td>\n",
       "      <td>0.00093</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002809</td>\n",
       "      <td>0.008287</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_SPIROCHAETAL</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                                            bestGenes bestColocGenes  \\\n",
       "0   [{'gene': {'id': 'ENSG00000132693', 'symbol': ...             []   \n",
       "1   [{'gene': {'id': 'ENSG00000235532', 'symbol': ...             []   \n",
       "2   [{'gene': {'id': 'ENSG00000135336', 'symbol': ...             []   \n",
       "3   [{'gene': {'id': 'ENSG00000234225', 'symbol': ...             []   \n",
       "4   [{'gene': {'id': 'ENSG00000263443', 'symbol': ...             []   \n",
       "5                                                  []             []   \n",
       "6                                                  []             []   \n",
       "7   [{'gene': {'id': 'ENSG00000273396', 'symbol': ...             []   \n",
       "8   [{'gene': {'id': 'ENSG00000132693', 'symbol': ...             []   \n",
       "9   [{'gene': {'id': 'ENSG00000235532', 'symbol': ...             []   \n",
       "10                                                 []             []   \n",
       "11  [{'gene': {'id': 'ENSG00000135316', 'symbol': ...             []   \n",
       "\n",
       "                                      bestLocus2Genes  pvalMantissa  \\\n",
       "0   [{'gene': {'id': 'ENSG00000132693', 'symbol': ...         7.347   \n",
       "1   [{'gene': {'id': 'ENSG00000118922', 'symbol': ...         4.621   \n",
       "2   [{'gene': {'id': 'ENSG00000118434', 'symbol': ...         1.263   \n",
       "3   [{'gene': {'id': 'ENSG00000268043', 'symbol': ...         2.788   \n",
       "4   [{'gene': {'id': 'ENSG00000178764', 'symbol': ...         2.100   \n",
       "5   [{'gene': {'id': 'ENSG00000112818', 'symbol': ...         2.015   \n",
       "6                                                  []         4.906   \n",
       "7   [{'gene': {'id': 'ENSG00000163132', 'symbol': ...         4.990   \n",
       "8   [{'gene': {'id': 'ENSG00000132693', 'symbol': ...         6.133   \n",
       "9   [{'gene': {'id': 'ENSG00000118922', 'symbol': ...         4.023   \n",
       "10  [{'gene': {'id': 'ENSG00000112818', 'symbol': ...         1.552   \n",
       "11                                                 []         4.612   \n",
       "\n",
       "    pvalExponent  credibleSetSize  ldSetSize  totalSetSize          pval  \\\n",
       "0            -10                3          4             4  7.347000e-10   \n",
       "1             -8                8          0             8  4.621000e-08   \n",
       "2             -8               27         60            63  1.263000e-08   \n",
       "3             -8                1          1             1  2.788000e-08   \n",
       "4             -8                3          0             3  2.100000e-08   \n",
       "5             -8                2          0             2  2.015000e-08   \n",
       "6             -8               13          0            13  4.906000e-08   \n",
       "7             -8                2         13            13  4.990000e-08   \n",
       "8            -10                3          4             4  6.133000e-10   \n",
       "9             -8                8          0             8  4.023000e-08   \n",
       "10            -9                2          0             2  1.552000e-09   \n",
       "11            -8                3          0             3  4.612000e-08   \n",
       "\n",
       "       oddsRatio  oddsRatioCILower  oddsRatioCIUpper  beta betaCILower  \\\n",
       "0   8.750275e-01      8.386280e-01      9.130068e-01  None        None   \n",
       "1   1.994114e+00      1.556870e+00      2.554158e+00  None        None   \n",
       "2   1.350399e+00      1.217672e+00      1.497592e+00  None        None   \n",
       "3   7.198589e-01      6.410213e-01      8.083926e-01  None        None   \n",
       "4   1.351209e+00      1.216182e+00      1.501228e+00  None        None   \n",
       "5   7.938578e+09      2.763396e+06      2.280564e+13  None        None   \n",
       "6   1.988523e+33      2.155591e+21      1.834402e+45  None        None   \n",
       "7   5.525010e-01      4.463710e-01      6.838647e-01  None        None   \n",
       "8   8.747650e-01      8.384610e-01      9.126409e-01  None        None   \n",
       "9   1.997507e+00      1.560296e+00      2.557230e+00  None        None   \n",
       "10  2.013449e+10      9.112824e+06      4.448650e+13  None        None   \n",
       "11  2.967738e+00      2.009148e+00      4.383682e+00  None        None   \n",
       "\n",
       "   betaCIUpper direction variant_chromosome  variant_position  \\\n",
       "0         None         -                  1         159743672   \n",
       "1         None         +                 13          74291635   \n",
       "2         None         +                  6          87971973   \n",
       "3         None         -                  1         147027146   \n",
       "4         None         +                  8         122593984   \n",
       "5         None         +                  6          46877116   \n",
       "6         None         +                  7          72005814   \n",
       "7         None         -                  4           4864861   \n",
       "8         None         -                  1         159743672   \n",
       "9         None         +                 13          74291635   \n",
       "10        None         +                  6          46877116   \n",
       "11        None         +                  6          86087207   \n",
       "\n",
       "   variant_refAllele variant_altAllele variant_rsId variant_chromosomeB37  \\\n",
       "0                  A                 G   rs74596724                     1   \n",
       "1                  C                 T  rs117832616                    13   \n",
       "2                  T                 C    rs2474884                     6   \n",
       "3                  G                 A   rs11587105                     1   \n",
       "4                  C                 T  rs117622394                     8   \n",
       "5                  T                 G         None                  None   \n",
       "6                  T                 C         None                  None   \n",
       "7                  A                 C    rs6825765                     4   \n",
       "8                  A                 G   rs74596724                     1   \n",
       "9                  C                 T  rs117832616                    13   \n",
       "10                 T                 G         None                  None   \n",
       "11                 T                 C  rs184239803                     6   \n",
       "\n",
       "   variant_positionB37       variant_id variant_nearestGene_id  \\\n",
       "0            159713462  1_159743672_A_G        ENSG00000132693   \n",
       "1             74865772  13_74291635_C_T        ENSG00000235532   \n",
       "2             88681691   6_87971973_T_C        ENSG00000118434   \n",
       "3            146498703  1_147027146_G_A        ENSG00000234225   \n",
       "4            123606223  8_122593984_C_T        ENSG00000253819   \n",
       "5                 None   6_46877116_T_G                    NaN   \n",
       "6                 None   7_72005814_T_C                    NaN   \n",
       "7              4866588    4_4864861_A_C        ENSG00000163132   \n",
       "8            159713462  1_159743672_A_G        ENSG00000132693   \n",
       "9             74865772  13_74291635_C_T        ENSG00000235532   \n",
       "10                None   6_46877116_T_G                    NaN   \n",
       "11            86796925   6_86087207_T_C        ENSG00000135316   \n",
       "\n",
       "   variant_nearestGene_symbol variant_nearestGene_bioType  \\\n",
       "0                         CRP              protein_coding   \n",
       "1                   LINC00402                     lincRNA   \n",
       "2                      SPACA1              protein_coding   \n",
       "3                  AC244394.2                     lincRNA   \n",
       "4                   LINC01151                     lincRNA   \n",
       "5                         NaN                         NaN   \n",
       "6                         NaN                         NaN   \n",
       "7                        MSX1              protein_coding   \n",
       "8                         CRP              protein_coding   \n",
       "9                   LINC00402                     lincRNA   \n",
       "10                        NaN                         NaN   \n",
       "11                    SYNCRIP              protein_coding   \n",
       "\n",
       "                      variant_nearestGene_description  \\\n",
       "0   C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "1   long intergenic non-protein coding RNA 402 [So...   \n",
       "2   sperm acrosome associated 1 [Source:HGNC Symbo...   \n",
       "3                                    novel transcript   \n",
       "4   long intergenic non-protein coding RNA 1151 [S...   \n",
       "5                                                 NaN   \n",
       "6                                                 NaN   \n",
       "7   msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "8   C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "9   long intergenic non-protein coding RNA 402 [So...   \n",
       "10                                                NaN   \n",
       "11  synaptotagmin binding cytoplasmic RNA interact...   \n",
       "\n",
       "   variant_nearestGene_chromosome  variant_nearestGene_tss  \\\n",
       "0                               1              159714589.0   \n",
       "1                              13               74231457.0   \n",
       "2                               6               88047841.0   \n",
       "3                               1              147003618.0   \n",
       "4                               8              122694106.0   \n",
       "5                             NaN                      NaN   \n",
       "6                             NaN                      NaN   \n",
       "7                               4                4859665.0   \n",
       "8                               1              159714589.0   \n",
       "9                              13               74231457.0   \n",
       "10                            NaN                      NaN   \n",
       "11                              6               85643792.0   \n",
       "\n",
       "    variant_nearestGene_start  variant_nearestGene_end  \\\n",
       "0                 159712289.0              159714589.0   \n",
       "1                  74231457.0               74259976.0   \n",
       "2                  88047841.0               88066838.0   \n",
       "3                 147001931.0              147003618.0   \n",
       "4                 122670385.0              122694106.0   \n",
       "5                         NaN                      NaN   \n",
       "6                         NaN                      NaN   \n",
       "7                   4859665.0                4863936.0   \n",
       "8                 159712289.0              159714589.0   \n",
       "9                  74231457.0               74259976.0   \n",
       "10                        NaN                      NaN   \n",
       "11                 85607785.0               85643792.0   \n",
       "\n",
       "   variant_nearestGene_fwdStrand  \\\n",
       "0                          False   \n",
       "1                           True   \n",
       "2                           True   \n",
       "3                          False   \n",
       "4                          False   \n",
       "5                            NaN   \n",
       "6                            NaN   \n",
       "7                           True   \n",
       "8                          False   \n",
       "9                           True   \n",
       "10                           NaN   \n",
       "11                         False   \n",
       "\n",
       "                            variant_nearestGene_exons  \\\n",
       "0        [159714425, 159714589, 159712289, 159714138]   \n",
       "1            [74256933, 74259976, 74231457, 74231752]   \n",
       "2   [88066182, 88066838, 88064099, 88064219, 88059...   \n",
       "3   [147001931, 147002332, 147002897, 147003191, 1...   \n",
       "4   [122670385, 122670500, 122671269, 122671388, 1...   \n",
       "5                                                 NaN   \n",
       "6                                                 NaN   \n",
       "7                [4862701, 4863936, 4859665, 4860368]   \n",
       "8        [159714425, 159714589, 159712289, 159714138]   \n",
       "9            [74256933, 74259976, 74231457, 74231752]   \n",
       "10                                                NaN   \n",
       "11  [85636967, 85637143, 85614106, 85615347, 85618...   \n",
       "\n",
       "   variant_nearestGeneDistance variant_nearestCodingGene_id  \\\n",
       "0                        29083              ENSG00000132693   \n",
       "1                        60178              ENSG00000118922   \n",
       "2                        75868              ENSG00000118434   \n",
       "3                        23528              ENSG00000268043   \n",
       "4                       100122              ENSG00000178764   \n",
       "5                         None                          NaN   \n",
       "6                         None                          NaN   \n",
       "7                         5196              ENSG00000163132   \n",
       "8                        29083              ENSG00000132693   \n",
       "9                        60178              ENSG00000118922   \n",
       "10                        None                          NaN   \n",
       "11                      443415              ENSG00000135316   \n",
       "\n",
       "   variant_nearestCodingGene_symbol variant_nearestCodingGene_bioType  \\\n",
       "0                               CRP                    protein_coding   \n",
       "1                             KLF12                    protein_coding   \n",
       "2                            SPACA1                    protein_coding   \n",
       "3                            NBPF12                    protein_coding   \n",
       "4                              ZHX2                    protein_coding   \n",
       "5                               NaN                               NaN   \n",
       "6                               NaN                               NaN   \n",
       "7                              MSX1                    protein_coding   \n",
       "8                               CRP                    protein_coding   \n",
       "9                             KLF12                    protein_coding   \n",
       "10                              NaN                               NaN   \n",
       "11                          SYNCRIP                    protein_coding   \n",
       "\n",
       "                variant_nearestCodingGene_description  \\\n",
       "0   C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "1   Kruppel like factor 12 [Source:HGNC Symbol;Acc...   \n",
       "2   sperm acrosome associated 1 [Source:HGNC Symbo...   \n",
       "3   NBPF member 12 [Source:HGNC Symbol;Acc:HGNC:24...   \n",
       "4   zinc fingers and homeoboxes 2 [Source:HGNC Sym...   \n",
       "5                                                 NaN   \n",
       "6                                                 NaN   \n",
       "7   msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "8   C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "9   Kruppel like factor 12 [Source:HGNC Symbol;Acc...   \n",
       "10                                                NaN   \n",
       "11  synaptotagmin binding cytoplasmic RNA interact...   \n",
       "\n",
       "   variant_nearestCodingGene_chromosome  variant_nearestCodingGene_tss  \\\n",
       "0                                     1                    159714589.0   \n",
       "1                                    13                     73995056.0   \n",
       "2                                     6                     88047841.0   \n",
       "3                                     1                    146938744.0   \n",
       "4                                     8                    122781655.0   \n",
       "5                                   NaN                            NaN   \n",
       "6                                   NaN                            NaN   \n",
       "7                                     4                      4859665.0   \n",
       "8                                     1                    159714589.0   \n",
       "9                                    13                     73995056.0   \n",
       "10                                  NaN                            NaN   \n",
       "11                                    6                     85643792.0   \n",
       "\n",
       "    variant_nearestCodingGene_start  variant_nearestCodingGene_end  \\\n",
       "0                       159712289.0                    159714589.0   \n",
       "1                        73686089.0                     73995056.0   \n",
       "2                        88047841.0                     88066838.0   \n",
       "3                       146938744.0                    146996202.0   \n",
       "4                       122781655.0                    122974510.0   \n",
       "5                               NaN                            NaN   \n",
       "6                               NaN                            NaN   \n",
       "7                         4859665.0                      4863936.0   \n",
       "8                       159712289.0                    159714589.0   \n",
       "9                        73686089.0                     73995056.0   \n",
       "10                              NaN                            NaN   \n",
       "11                       85607785.0                     85643792.0   \n",
       "\n",
       "   variant_nearestCodingGene_fwdStrand  \\\n",
       "0                                False   \n",
       "1                                False   \n",
       "2                                 True   \n",
       "3                                 True   \n",
       "4                                 True   \n",
       "5                                  NaN   \n",
       "6                                  NaN   \n",
       "7                                 True   \n",
       "8                                False   \n",
       "9                                False   \n",
       "10                                 NaN   \n",
       "11                               False   \n",
       "\n",
       "                      variant_nearestCodingGene_exons  \\\n",
       "0        [159714425, 159714589, 159712289, 159714138]   \n",
       "1   [73686089, 73695671, 73715368, 73715525, 73764...   \n",
       "2   [88066182, 88066838, 88064099, 88064219, 88059...   \n",
       "3   [146987954, 146988126, 146987234, 146987285, 1...   \n",
       "4   [122973242, 122974510, 122951292, 122954028, 1...   \n",
       "5                                                 NaN   \n",
       "6                                                 NaN   \n",
       "7                [4862701, 4863936, 4859665, 4860368]   \n",
       "8        [159714425, 159714589, 159712289, 159714138]   \n",
       "9   [73686089, 73695671, 73715368, 73715525, 73764...   \n",
       "10                                                NaN   \n",
       "11  [85636967, 85637143, 85614106, 85615347, 85618...   \n",
       "\n",
       "   variant_nearestCodingGeneDistance variant_mostSevereConsequence  \\\n",
       "0                              29083            intergenic_variant   \n",
       "1                             296579         upstream_gene_variant   \n",
       "2                              75868            intergenic_variant   \n",
       "3                              88402                intron_variant   \n",
       "4                             187671            intergenic_variant   \n",
       "5                               None                          None   \n",
       "6                               None                          None   \n",
       "7                               5196       downstream_gene_variant   \n",
       "8                              29083            intergenic_variant   \n",
       "9                             296579         upstream_gene_variant   \n",
       "10                              None                          None   \n",
       "11                            443415         upstream_gene_variant   \n",
       "\n",
       "   variant_caddRaw variant_caddPhred variant_gnomadAFR variant_gnomadAMR  \\\n",
       "0         0.770176             11.64          0.011703          0.040094   \n",
       "1         -0.24534             0.528                 0          0.002358   \n",
       "2         0.263616             6.735          0.432896          0.116745   \n",
       "3        -0.260592             0.476          0.168334           0.15566   \n",
       "4         0.006131             2.717          0.002066          0.005896   \n",
       "5             None              None              None              None   \n",
       "6             None              None              None              None   \n",
       "7         0.129132             4.745          0.468369          0.612028   \n",
       "8         0.770176             11.64          0.011703          0.040094   \n",
       "9         -0.24534             0.528                 0          0.002358   \n",
       "10            None              None              None              None   \n",
       "11       -0.082352             1.574                 0                 0   \n",
       "\n",
       "   variant_gnomadASJ variant_gnomadEAS variant_gnomadFIN variant_gnomadNFE  \\\n",
       "0           0.096552          0.164103          0.063364          0.075765   \n",
       "1                  0          0.010296          0.003165          0.000519   \n",
       "2           0.177083          0.120513          0.122984           0.15179   \n",
       "3           0.248276          0.107742          0.142607          0.243909   \n",
       "4           0.024138                 0          0.014113          0.014388   \n",
       "5               None              None              None              None   \n",
       "6               None              None              None              None   \n",
       "7           0.375862          0.652706          0.601729          0.464031   \n",
       "8           0.096552          0.164103          0.063364          0.075765   \n",
       "9                  0          0.010296          0.003165          0.000519   \n",
       "10              None              None              None              None   \n",
       "11                 0                 0          0.016983          0.003953   \n",
       "\n",
       "   variant_gnomadNFEEST variant_gnomadNFENWE variant_gnomadNFESEU  \\\n",
       "0              0.096288             0.067939              0.09434   \n",
       "1              0.001093             0.000116                    0   \n",
       "2               0.16027             0.150675             0.150943   \n",
       "3              0.171875             0.278828             0.264151   \n",
       "4              0.020897             0.011636                    0   \n",
       "5                  None                 None                 None   \n",
       "6                  None                 None                 None   \n",
       "7              0.508534             0.448545             0.443396   \n",
       "8              0.096288             0.067939              0.09434   \n",
       "9              0.001093             0.000116                    0   \n",
       "10                 None                 None                 None   \n",
       "11             0.010235              0.00093                    0   \n",
       "\n",
       "   variant_gnomadNFEONF variant_gnomadOTH                               study  \\\n",
       "0              0.062324            0.0625          FINNGEN_R5_AB1_BACTINF_NOS   \n",
       "1              0.000935                 0          FINNGEN_R5_AB1_BACTINF_NOS   \n",
       "2              0.138109          0.168199      FINNGEN_R5_AB1_DERMATOPHYTOSIS   \n",
       "3              0.256098          0.185874                  FINNGEN_R5_AB1_EBV   \n",
       "4              0.012172           0.01107  FINNGEN_R5_AB1_GASTROENTERITIS_NOS   \n",
       "5                  None              None         FINNGEN_R5_AB1_GHLAMY_OTHER   \n",
       "6                  None              None              FINNGEN_R5_AB1_MALARIA   \n",
       "7              0.432116           0.48893              FINNGEN_R5_AB1_MEASLES   \n",
       "8              0.062324            0.0625      FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "9              0.000935                 0      FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "10                 None              None     FINNGEN_R5_AB1_OTHER_CHLAMYDIAE   \n",
       "11             0.002809          0.008287   FINNGEN_R5_AB1_OTHER_SPIROCHAETAL   \n",
       "\n",
       "   variant_nearestGene variant_nearestCodingGene  \n",
       "0                  NaN                       NaN  \n",
       "1                  NaN                       NaN  \n",
       "2                  NaN                       NaN  \n",
       "3                  NaN                       NaN  \n",
       "4                  NaN                       NaN  \n",
       "5                 None                      None  \n",
       "6                 None                      None  \n",
       "7                  NaN                       NaN  \n",
       "8                  NaN                       NaN  \n",
       "9                  NaN                       NaN  \n",
       "10                None                      None  \n",
       "11                 NaN                       NaN  "
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "df = api.manhattan(split_studies[0][:10])\n",
    "df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[0.6587790846824646,\n",
       " 0.8584963083267212,\n",
       " 0.6729658842086792,\n",
       " 0.7262475490570068,\n",
       " 0.6944537162780762,\n",
       " 0.6906188130378723,\n",
       " 0.6779915690422058,\n",
       " 0.6587790846824646,\n",
       " 0.8585225939750671,\n",
       " 0.6522198915481567]"
      ]
     },
     "execution_count": 22,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "[x[0]['score'] for x in df.bestLocus2Genes if len(x)]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 58,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "9f4e043a87c44e67afe7124209259cba",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/1705 [00:00<?, ?it/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 24min 41s, sys: 6.77 s, total: 24min 48s\n",
      "Wall time: 1h 17min 21s\n"
     ]
    }
   ],
   "source": [
    "%%time\n",
    "\n",
    "info = []\n",
    "bestgenes = []\n",
    "\n",
    "for st in tqdm(split_studies):\n",
    "    info.append(api.study_info(st))\n",
    "    time.sleep(0.2)\n",
    "    bestgenes.append(api.manhattan(st))\n",
    "    time.sleep(0.2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "metadata": {},
   "outputs": [],
   "source": [
    "info_df = pd.concat(info, axis=0).reset_index(drop=True)\n",
    "bestgenes_df = pd.concat(bestgenes, axis=0).reset_index(drop=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 60,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "((17054, 18), (225064, 63))"
      ]
     },
     "execution_count": 60,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "info_df.shape, bestgenes_df.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>studyId</th>\n",
       "      <th>traitReported</th>\n",
       "      <th>source</th>\n",
       "      <th>traitEfos</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pubDate</th>\n",
       "      <th>pubJournal</th>\n",
       "      <th>pubTitle</th>\n",
       "      <th>pubAuthor</th>\n",
       "      <th>hasSumstats</th>\n",
       "      <th>ancestryInitial</th>\n",
       "      <th>ancestryReplication</th>\n",
       "      <th>nInitial</th>\n",
       "      <th>nReplication</th>\n",
       "      <th>nCases</th>\n",
       "      <th>traitCategory</th>\n",
       "      <th>numAssocLoci</th>\n",
       "      <th>nTotal</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>14647</th>\n",
       "      <td>GCST90000025</td>\n",
       "      <td>Appendicular lean mass</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004980]</td>\n",
       "      <td>PMID:33097823</td>\n",
       "      <td>2020-10-23</td>\n",
       "      <td>Commun Biol</td>\n",
       "      <td>The genetic architecture of appendicular lean ...</td>\n",
       "      <td>Pei YF</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=450243]</td>\n",
       "      <td>[]</td>\n",
       "      <td>450243</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1538</td>\n",
       "      <td>450243</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16511</th>\n",
       "      <td>NEALE2_50_raw</td>\n",
       "      <td>Standing height</td>\n",
       "      <td>NEALE</td>\n",
       "      <td>[EFO_0004339]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-08-01</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB Neale v2</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=360388]</td>\n",
       "      <td>[]</td>\n",
       "      <td>360388</td>\n",
       "      <td>0</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1526</td>\n",
       "      <td>360388</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10345</th>\n",
       "      <td>GCST007841</td>\n",
       "      <td>Height</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004339]</td>\n",
       "      <td>PMID:30595370</td>\n",
       "      <td>2018-12-27</td>\n",
       "      <td>Am J Hum Genet</td>\n",
       "      <td>Leveraging Polygenic Functional Enrichment to ...</td>\n",
       "      <td>Kichaev G</td>\n",
       "      <td>False</td>\n",
       "      <td>[European=458000]</td>\n",
       "      <td>[]</td>\n",
       "      <td>458000</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1409</td>\n",
       "      <td>458000</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7577</th>\n",
       "      <td>GCST006571</td>\n",
       "      <td>Educational attainment (MTAG) [MTAG]</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004784]</td>\n",
       "      <td>PMID:30038396</td>\n",
       "      <td>2018-07-23</td>\n",
       "      <td>Nat Genet</td>\n",
       "      <td>Gene discovery and polygenic prediction from a...</td>\n",
       "      <td>Lee JJ</td>\n",
       "      <td>False</td>\n",
       "      <td>[European=1131438]</td>\n",
       "      <td>[]</td>\n",
       "      <td>1131438</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1366</td>\n",
       "      <td>1131438</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14768</th>\n",
       "      <td>GCST90002357</td>\n",
       "      <td>Platelet count</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004309]</td>\n",
       "      <td>PMID:32888493</td>\n",
       "      <td>2020-09-01</td>\n",
       "      <td>Cell</td>\n",
       "      <td>Trans-ethnic and Ancestry-Specific Blood-Cell ...</td>\n",
       "      <td>Chen MH</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=542827]</td>\n",
       "      <td>[]</td>\n",
       "      <td>542827</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1252</td>\n",
       "      <td>542827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7574</th>\n",
       "      <td>GCST006568</td>\n",
       "      <td>Highest math class taken (MTAG) [MTAG]</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004875]</td>\n",
       "      <td>PMID:30038396</td>\n",
       "      <td>2018-07-23</td>\n",
       "      <td>Nat Genet</td>\n",
       "      <td>Gene discovery and polygenic prediction from a...</td>\n",
       "      <td>Lee JJ</td>\n",
       "      <td>False</td>\n",
       "      <td>[European=811539]</td>\n",
       "      <td>[]</td>\n",
       "      <td>811539</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>biological process</td>\n",
       "      <td>1129</td>\n",
       "      <td>811539</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14745</th>\n",
       "      <td>GCST90002334</td>\n",
       "      <td>Mean corpuscular volume</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004526]</td>\n",
       "      <td>PMID:32888493</td>\n",
       "      <td>2020-09-01</td>\n",
       "      <td>Cell</td>\n",
       "      <td>Trans-ethnic and Ancestry-Specific Blood-Cell ...</td>\n",
       "      <td>Chen MH</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=544127]</td>\n",
       "      <td>[]</td>\n",
       "      <td>544127</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1121</td>\n",
       "      <td>544127</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14774</th>\n",
       "      <td>GCST90002363</td>\n",
       "      <td>Red blood cell count</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0007978]</td>\n",
       "      <td>PMID:32888493</td>\n",
       "      <td>2020-09-01</td>\n",
       "      <td>Cell</td>\n",
       "      <td>Trans-ethnic and Ancestry-Specific Blood-Cell ...</td>\n",
       "      <td>Chen MH</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=545203]</td>\n",
       "      <td>[]</td>\n",
       "      <td>545203</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1119</td>\n",
       "      <td>545203</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14785</th>\n",
       "      <td>GCST90002374</td>\n",
       "      <td>White blood cell count</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0007988]</td>\n",
       "      <td>PMID:32888493</td>\n",
       "      <td>2020-09-01</td>\n",
       "      <td>Cell</td>\n",
       "      <td>Trans-ethnic and Ancestry-Specific Blood-Cell ...</td>\n",
       "      <td>Chen MH</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=562243]</td>\n",
       "      <td>[]</td>\n",
       "      <td>562243</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1042</td>\n",
       "      <td>562243</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14757</th>\n",
       "      <td>GCST90002346</td>\n",
       "      <td>Mean platelet volume</td>\n",
       "      <td>GCST</td>\n",
       "      <td>[EFO_0004584]</td>\n",
       "      <td>PMID:32888493</td>\n",
       "      <td>2020-09-01</td>\n",
       "      <td>Cell</td>\n",
       "      <td>Trans-ethnic and Ancestry-Specific Blood-Cell ...</td>\n",
       "      <td>Chen MH</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=460935]</td>\n",
       "      <td>[]</td>\n",
       "      <td>460935</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>measurement</td>\n",
       "      <td>1037</td>\n",
       "      <td>460935</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "             studyId                           traitReported source  \\\n",
       "14647   GCST90000025                  Appendicular lean mass   GCST   \n",
       "16511  NEALE2_50_raw                         Standing height  NEALE   \n",
       "10345     GCST007841                                  Height   GCST   \n",
       "7577      GCST006571    Educational attainment (MTAG) [MTAG]   GCST   \n",
       "14768   GCST90002357                          Platelet count   GCST   \n",
       "7574      GCST006568  Highest math class taken (MTAG) [MTAG]   GCST   \n",
       "14745   GCST90002334                 Mean corpuscular volume   GCST   \n",
       "14774   GCST90002363                    Red blood cell count   GCST   \n",
       "14785   GCST90002374                  White blood cell count   GCST   \n",
       "14757   GCST90002346                    Mean platelet volume   GCST   \n",
       "\n",
       "           traitEfos           pmid     pubDate      pubJournal  \\\n",
       "14647  [EFO_0004980]  PMID:33097823  2020-10-23     Commun Biol   \n",
       "16511  [EFO_0004339]           None  2018-08-01            None   \n",
       "10345  [EFO_0004339]  PMID:30595370  2018-12-27  Am J Hum Genet   \n",
       "7577   [EFO_0004784]  PMID:30038396  2018-07-23       Nat Genet   \n",
       "14768  [EFO_0004309]  PMID:32888493  2020-09-01            Cell   \n",
       "7574   [EFO_0004875]  PMID:30038396  2018-07-23       Nat Genet   \n",
       "14745  [EFO_0004526]  PMID:32888493  2020-09-01            Cell   \n",
       "14774  [EFO_0007978]  PMID:32888493  2020-09-01            Cell   \n",
       "14785  [EFO_0007988]  PMID:32888493  2020-09-01            Cell   \n",
       "14757  [EFO_0004584]  PMID:32888493  2020-09-01            Cell   \n",
       "\n",
       "                                                pubTitle     pubAuthor  \\\n",
       "14647  The genetic architecture of appendicular lean ...        Pei YF   \n",
       "16511                                               None  UKB Neale v2   \n",
       "10345  Leveraging Polygenic Functional Enrichment to ...     Kichaev G   \n",
       "7577   Gene discovery and polygenic prediction from a...        Lee JJ   \n",
       "14768  Trans-ethnic and Ancestry-Specific Blood-Cell ...       Chen MH   \n",
       "7574   Gene discovery and polygenic prediction from a...        Lee JJ   \n",
       "14745  Trans-ethnic and Ancestry-Specific Blood-Cell ...       Chen MH   \n",
       "14774  Trans-ethnic and Ancestry-Specific Blood-Cell ...       Chen MH   \n",
       "14785  Trans-ethnic and Ancestry-Specific Blood-Cell ...       Chen MH   \n",
       "14757  Trans-ethnic and Ancestry-Specific Blood-Cell ...       Chen MH   \n",
       "\n",
       "       hasSumstats     ancestryInitial ancestryReplication  nInitial  \\\n",
       "14647         True   [European=450243]                  []    450243   \n",
       "16511         True   [European=360388]                  []    360388   \n",
       "10345        False   [European=458000]                  []    458000   \n",
       "7577         False  [European=1131438]                  []   1131438   \n",
       "14768         True   [European=542827]                  []    542827   \n",
       "7574         False   [European=811539]                  []    811539   \n",
       "14745         True   [European=544127]                  []    544127   \n",
       "14774         True   [European=545203]                  []    545203   \n",
       "14785         True   [European=562243]                  []    562243   \n",
       "14757         True   [European=460935]                  []    460935   \n",
       "\n",
       "      nReplication nCases       traitCategory  numAssocLoci   nTotal  \n",
       "14647          NaN    NaN         measurement          1538   450243  \n",
       "16511            0   None         measurement          1526   360388  \n",
       "10345          NaN    NaN         measurement          1409   458000  \n",
       "7577          None    NaN         measurement          1366  1131438  \n",
       "14768         None   None         measurement          1252   542827  \n",
       "7574          None    NaN  biological process          1129   811539  \n",
       "14745         None   None         measurement          1121   544127  \n",
       "14774         None   None         measurement          1119   545203  \n",
       "14785         None   None         measurement          1042   562243  \n",
       "14757         None   None         measurement          1037   460935  "
      ]
     },
     "execution_count": 61,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "info_df.sort_values('numAssocLoci', ascending=False).head(10)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 62,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>bestGenes</th>\n",
       "      <th>bestColocGenes</th>\n",
       "      <th>bestLocus2Genes</th>\n",
       "      <th>pvalMantissa</th>\n",
       "      <th>pvalExponent</th>\n",
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       "      <th>variant_refAllele</th>\n",
       "      <th>variant_altAllele</th>\n",
       "      <th>variant_rsId</th>\n",
       "      <th>variant_chromosomeB37</th>\n",
       "      <th>variant_positionB37</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_nearestGene</th>\n",
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       "      <th>variant_nearestCodingGene</th>\n",
       "      <th>variant_nearestCodingGeneDistance</th>\n",
       "      <th>variant_mostSevereConsequence</th>\n",
       "      <th>variant_caddRaw</th>\n",
       "      <th>variant_caddPhred</th>\n",
       "      <th>variant_gnomadAFR</th>\n",
       "      <th>variant_gnomadAMR</th>\n",
       "      <th>variant_gnomadASJ</th>\n",
       "      <th>variant_gnomadEAS</th>\n",
       "      <th>variant_gnomadFIN</th>\n",
       "      <th>variant_gnomadNFE</th>\n",
       "      <th>variant_gnomadNFEEST</th>\n",
       "      <th>variant_gnomadNFENWE</th>\n",
       "      <th>variant_gnomadNFESEU</th>\n",
       "      <th>variant_gnomadNFEONF</th>\n",
       "      <th>variant_gnomadOTH</th>\n",
       "      <th>study</th>\n",
       "      <th>variant_nearestGene_id</th>\n",
       "      <th>variant_nearestGene_symbol</th>\n",
       "      <th>variant_nearestGene_bioType</th>\n",
       "      <th>variant_nearestGene_description</th>\n",
       "      <th>variant_nearestGene_chromosome</th>\n",
       "      <th>variant_nearestGene_tss</th>\n",
       "      <th>variant_nearestGene_start</th>\n",
       "      <th>variant_nearestGene_end</th>\n",
       "      <th>variant_nearestGene_fwdStrand</th>\n",
       "      <th>variant_nearestGene_exons</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>variant_nearestCodingGene_bioType</th>\n",
       "      <th>variant_nearestCodingGene_description</th>\n",
       "      <th>variant_nearestCodingGene_chromosome</th>\n",
       "      <th>variant_nearestCodingGene_tss</th>\n",
       "      <th>variant_nearestCodingGene_start</th>\n",
       "      <th>variant_nearestCodingGene_end</th>\n",
       "      <th>variant_nearestCodingGene_fwdStrand</th>\n",
       "      <th>variant_nearestCodingGene_exons</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000112818', 'symbol': ...</td>\n",
       "      <td>2.015</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>2.015000e-08</td>\n",
       "      <td>7938577976.443386</td>\n",
       "      <td>2763395.679138</td>\n",
       "      <td>22805644795582.570312</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5_AB1_GHLAMY_OTHER</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>[]</td>\n",
       "      <td>4.906</td>\n",
       "      <td>-8</td>\n",
       "      <td>13</td>\n",
       "      <td>0</td>\n",
       "      <td>13</td>\n",
       "      <td>4.906000e-08</td>\n",
       "      <td>1988522560716156536299995277557760.0</td>\n",
       "      <td>2155591248384895221760.0</td>\n",
       "      <td>1834402499750309139325894491420177766780239872.0</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>7</td>\n",
       "      <td>72005814</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>7_72005814_T_C</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5_AB1_MALARIA</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000273396', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000163132', 'symbol': ...</td>\n",
       "      <td>4.990</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>13</td>\n",
       "      <td>13</td>\n",
       "      <td>4.990000e-08</td>\n",
       "      <td>0.552501</td>\n",
       "      <td>0.446371</td>\n",
       "      <td>0.683865</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>4</td>\n",
       "      <td>4864861</td>\n",
       "      <td>A</td>\n",
       "      <td>C</td>\n",
       "      <td>rs6825765</td>\n",
       "      <td>4</td>\n",
       "      <td>4866588</td>\n",
       "      <td>4_4864861_A_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>downstream_gene_variant</td>\n",
       "      <td>0.129132</td>\n",
       "      <td>4.745</td>\n",
       "      <td>0.468369</td>\n",
       "      <td>0.612028</td>\n",
       "      <td>0.375862</td>\n",
       "      <td>0.652706</td>\n",
       "      <td>0.601729</td>\n",
       "      <td>0.464031</td>\n",
       "      <td>0.508534</td>\n",
       "      <td>0.448545</td>\n",
       "      <td>0.443396</td>\n",
       "      <td>0.432116</td>\n",
       "      <td>0.48893</td>\n",
       "      <td>FINNGEN_R5_AB1_MEASLES</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000132693', 'symbol': ...</td>\n",
       "      <td>6.133</td>\n",
       "      <td>-10</td>\n",
       "      <td>3</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>6.133000e-10</td>\n",
       "      <td>0.874765</td>\n",
       "      <td>0.838461</td>\n",
       "      <td>0.912641</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>159743672</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs74596724</td>\n",
       "      <td>1</td>\n",
       "      <td>159713462</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.770176</td>\n",
       "      <td>11.64</td>\n",
       "      <td>0.011703</td>\n",
       "      <td>0.040094</td>\n",
       "      <td>0.096552</td>\n",
       "      <td>0.164103</td>\n",
       "      <td>0.063364</td>\n",
       "      <td>0.075765</td>\n",
       "      <td>0.096288</td>\n",
       "      <td>0.067939</td>\n",
       "      <td>0.09434</td>\n",
       "      <td>0.062324</td>\n",
       "      <td>0.0625</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>[{'gene': {'id': 'ENSG00000235532', 'symbol': ...</td>\n",
       "      <td>[]</td>\n",
       "      <td>[{'gene': {'id': 'ENSG00000118922', 'symbol': ...</td>\n",
       "      <td>4.023</td>\n",
       "      <td>-8</td>\n",
       "      <td>8</td>\n",
       "      <td>0</td>\n",
       "      <td>8</td>\n",
       "      <td>4.023000e-08</td>\n",
       "      <td>1.997507</td>\n",
       "      <td>1.560296</td>\n",
       "      <td>2.55723</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>13</td>\n",
       "      <td>74291635</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117832616</td>\n",
       "      <td>13</td>\n",
       "      <td>74865772</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>60178</td>\n",
       "      <td>NaN</td>\n",
       "      <td>296579</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.24534</td>\n",
       "      <td>0.528</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002358</td>\n",
       "      <td>0</td>\n",
       "      <td>0.010296</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.000519</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000935</td>\n",
       "      <td>0</td>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>ENSG00000235532</td>\n",
       "      <td>LINC00402</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 402 [So...</td>\n",
       "      <td>13</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74259976.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[74256933, 74259976, 74231457, 74231752]</td>\n",
       "      <td>ENSG00000118922</td>\n",
       "      <td>KLF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Kruppel like factor 12 [Source:HGNC Symbol;Acc...</td>\n",
       "      <td>13</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>73686089.0</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[73686089, 73695671, 73715368, 73715525, 73764...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                                           bestGenes bestColocGenes  \\\n",
       "0                                                 []             []   \n",
       "1                                                 []             []   \n",
       "2  [{'gene': {'id': 'ENSG00000273396', 'symbol': ...             []   \n",
       "3  [{'gene': {'id': 'ENSG00000132693', 'symbol': ...             []   \n",
       "4  [{'gene': {'id': 'ENSG00000235532', 'symbol': ...             []   \n",
       "\n",
       "                                     bestLocus2Genes  pvalMantissa  \\\n",
       "0  [{'gene': {'id': 'ENSG00000112818', 'symbol': ...         2.015   \n",
       "1                                                 []         4.906   \n",
       "2  [{'gene': {'id': 'ENSG00000163132', 'symbol': ...         4.990   \n",
       "3  [{'gene': {'id': 'ENSG00000132693', 'symbol': ...         6.133   \n",
       "4  [{'gene': {'id': 'ENSG00000118922', 'symbol': ...         4.023   \n",
       "\n",
       "   pvalExponent  credibleSetSize  ldSetSize  totalSetSize          pval  \\\n",
       "0            -8                2          0             2  2.015000e-08   \n",
       "1            -8               13          0            13  4.906000e-08   \n",
       "2            -8                2         13            13  4.990000e-08   \n",
       "3           -10                3          4             4  6.133000e-10   \n",
       "4            -8                8          0             8  4.023000e-08   \n",
       "\n",
       "                              oddsRatio          oddsRatioCILower  \\\n",
       "0                     7938577976.443386            2763395.679138   \n",
       "1  1988522560716156536299995277557760.0  2155591248384895221760.0   \n",
       "2                              0.552501                  0.446371   \n",
       "3                              0.874765                  0.838461   \n",
       "4                              1.997507                  1.560296   \n",
       "\n",
       "                                   oddsRatioCIUpper  beta betaCILower  \\\n",
       "0                             22805644795582.570312  None        None   \n",
       "1  1834402499750309139325894491420177766780239872.0  None        None   \n",
       "2                                          0.683865  None        None   \n",
       "3                                          0.912641  None        None   \n",
       "4                                           2.55723  None        None   \n",
       "\n",
       "  betaCIUpper direction variant_chromosome  variant_position  \\\n",
       "0        None         +                  6          46877116   \n",
       "1        None         +                  7          72005814   \n",
       "2        None         -                  4           4864861   \n",
       "3        None         -                  1         159743672   \n",
       "4        None         +                 13          74291635   \n",
       "\n",
       "  variant_refAllele variant_altAllele variant_rsId variant_chromosomeB37  \\\n",
       "0                 T                 G         None                  None   \n",
       "1                 T                 C         None                  None   \n",
       "2                 A                 C    rs6825765                     4   \n",
       "3                 A                 G   rs74596724                     1   \n",
       "4                 C                 T  rs117832616                    13   \n",
       "\n",
       "  variant_positionB37       variant_id variant_nearestGene  \\\n",
       "0                None   6_46877116_T_G                None   \n",
       "1                None   7_72005814_T_C                None   \n",
       "2             4866588    4_4864861_A_C                 NaN   \n",
       "3           159713462  1_159743672_A_G                 NaN   \n",
       "4            74865772  13_74291635_C_T                 NaN   \n",
       "\n",
       "  variant_nearestGeneDistance variant_nearestCodingGene  \\\n",
       "0                        None                      None   \n",
       "1                        None                      None   \n",
       "2                        5196                       NaN   \n",
       "3                       29083                       NaN   \n",
       "4                       60178                       NaN   \n",
       "\n",
       "  variant_nearestCodingGeneDistance variant_mostSevereConsequence  \\\n",
       "0                              None                          None   \n",
       "1                              None                          None   \n",
       "2                              5196       downstream_gene_variant   \n",
       "3                             29083            intergenic_variant   \n",
       "4                            296579         upstream_gene_variant   \n",
       "\n",
       "  variant_caddRaw variant_caddPhred variant_gnomadAFR variant_gnomadAMR  \\\n",
       "0            None              None              None              None   \n",
       "1            None              None              None              None   \n",
       "2        0.129132             4.745          0.468369          0.612028   \n",
       "3        0.770176             11.64          0.011703          0.040094   \n",
       "4        -0.24534             0.528                 0          0.002358   \n",
       "\n",
       "  variant_gnomadASJ variant_gnomadEAS variant_gnomadFIN variant_gnomadNFE  \\\n",
       "0              None              None              None              None   \n",
       "1              None              None              None              None   \n",
       "2          0.375862          0.652706          0.601729          0.464031   \n",
       "3          0.096552          0.164103          0.063364          0.075765   \n",
       "4                 0          0.010296          0.003165          0.000519   \n",
       "\n",
       "  variant_gnomadNFEEST variant_gnomadNFENWE variant_gnomadNFESEU  \\\n",
       "0                 None                 None                 None   \n",
       "1                 None                 None                 None   \n",
       "2             0.508534             0.448545             0.443396   \n",
       "3             0.096288             0.067939              0.09434   \n",
       "4             0.001093             0.000116                    0   \n",
       "\n",
       "  variant_gnomadNFEONF variant_gnomadOTH                           study  \\\n",
       "0                 None              None     FINNGEN_R5_AB1_GHLAMY_OTHER   \n",
       "1                 None              None          FINNGEN_R5_AB1_MALARIA   \n",
       "2             0.432116           0.48893          FINNGEN_R5_AB1_MEASLES   \n",
       "3             0.062324            0.0625  FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "4             0.000935                 0  FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "\n",
       "  variant_nearestGene_id variant_nearestGene_symbol  \\\n",
       "0                    NaN                        NaN   \n",
       "1                    NaN                        NaN   \n",
       "2        ENSG00000163132                       MSX1   \n",
       "3        ENSG00000132693                        CRP   \n",
       "4        ENSG00000235532                  LINC00402   \n",
       "\n",
       "  variant_nearestGene_bioType  \\\n",
       "0                         NaN   \n",
       "1                         NaN   \n",
       "2              protein_coding   \n",
       "3              protein_coding   \n",
       "4                     lincRNA   \n",
       "\n",
       "                     variant_nearestGene_description  \\\n",
       "0                                                NaN   \n",
       "1                                                NaN   \n",
       "2  msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "3  C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "4  long intergenic non-protein coding RNA 402 [So...   \n",
       "\n",
       "  variant_nearestGene_chromosome  variant_nearestGene_tss  \\\n",
       "0                            NaN                      NaN   \n",
       "1                            NaN                      NaN   \n",
       "2                              4                4859665.0   \n",
       "3                              1              159714589.0   \n",
       "4                             13               74231457.0   \n",
       "\n",
       "   variant_nearestGene_start  variant_nearestGene_end  \\\n",
       "0                        NaN                      NaN   \n",
       "1                        NaN                      NaN   \n",
       "2                  4859665.0                4863936.0   \n",
       "3                159712289.0              159714589.0   \n",
       "4                 74231457.0               74259976.0   \n",
       "\n",
       "  variant_nearestGene_fwdStrand                     variant_nearestGene_exons  \\\n",
       "0                           NaN                                           NaN   \n",
       "1                           NaN                                           NaN   \n",
       "2                          True          [4862701, 4863936, 4859665, 4860368]   \n",
       "3                         False  [159714425, 159714589, 159712289, 159714138]   \n",
       "4                          True      [74256933, 74259976, 74231457, 74231752]   \n",
       "\n",
       "  variant_nearestCodingGene_id variant_nearestCodingGene_symbol  \\\n",
       "0                          NaN                              NaN   \n",
       "1                          NaN                              NaN   \n",
       "2              ENSG00000163132                             MSX1   \n",
       "3              ENSG00000132693                              CRP   \n",
       "4              ENSG00000118922                            KLF12   \n",
       "\n",
       "  variant_nearestCodingGene_bioType  \\\n",
       "0                               NaN   \n",
       "1                               NaN   \n",
       "2                    protein_coding   \n",
       "3                    protein_coding   \n",
       "4                    protein_coding   \n",
       "\n",
       "               variant_nearestCodingGene_description  \\\n",
       "0                                                NaN   \n",
       "1                                                NaN   \n",
       "2  msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "3  C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "4  Kruppel like factor 12 [Source:HGNC Symbol;Acc...   \n",
       "\n",
       "  variant_nearestCodingGene_chromosome  variant_nearestCodingGene_tss  \\\n",
       "0                                  NaN                            NaN   \n",
       "1                                  NaN                            NaN   \n",
       "2                                    4                      4859665.0   \n",
       "3                                    1                    159714589.0   \n",
       "4                                   13                     73995056.0   \n",
       "\n",
       "   variant_nearestCodingGene_start  variant_nearestCodingGene_end  \\\n",
       "0                              NaN                            NaN   \n",
       "1                              NaN                            NaN   \n",
       "2                        4859665.0                      4863936.0   \n",
       "3                      159712289.0                    159714589.0   \n",
       "4                       73686089.0                     73995056.0   \n",
       "\n",
       "  variant_nearestCodingGene_fwdStrand  \\\n",
       "0                                 NaN   \n",
       "1                                 NaN   \n",
       "2                                True   \n",
       "3                               False   \n",
       "4                               False   \n",
       "\n",
       "                     variant_nearestCodingGene_exons  \n",
       "0                                                NaN  \n",
       "1                                                NaN  \n",
       "2               [4862701, 4863936, 4859665, 4860368]  \n",
       "3       [159714425, 159714589, 159712289, 159714138]  \n",
       "4  [73686089, 73695671, 73715368, 73715525, 73764...  "
      ]
     },
     "execution_count": 62,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.head()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Expand bestGenes columns and make a new bestLocus2GenesOrClosest column which uses the closest gene if L2G is empty"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 63,
   "metadata": {},
   "outputs": [],
   "source": [
    "bestgenes_df['bestGenes_id'] = [tuple([y['gene']['id'] for y in x]) for x in bestgenes_df.bestGenes]\n",
    "bestgenes_df['bestGenes_symbol'] = [tuple([y['gene']['symbol'] for y in x]) for x in bestgenes_df.bestGenes]\n",
    "\n",
    "bestgenes_df['bestColocGenes_id'] = [tuple([y['gene']['id'] for y in x]) for x in bestgenes_df.bestColocGenes]\n",
    "bestgenes_df['bestColocGenes_symbol'] = [tuple([y['gene']['symbol'] for y in x]) for x in bestgenes_df.bestColocGenes]\n",
    "\n",
    "bestgenes_df['bestLocus2Genes_id'] = [tuple([y['gene']['id'] for y in x]) for x in bestgenes_df.bestLocus2Genes]\n",
    "bestgenes_df['bestLocus2Genes_symbol'] = [tuple([y['gene']['symbol'] for y in x]) for x in bestgenes_df.bestLocus2Genes]\n",
    "bestgenes_df['bestLocus2Genes_score'] = [tuple([y['score'] for y in x]) for x in bestgenes_df.bestLocus2Genes]\n",
    "\n",
    "bestgenes_df['bestLocus2GenesOrClosest_id'] = [x if x else (y,) for x,y in zip(bestgenes_df.bestLocus2Genes_id, bestgenes_df.variant_nearestCodingGene_id)]\n",
    "bestgenes_df['bestLocus2GenesOrClosest_symbol'] = [x if x else (y,) for x,y in zip(bestgenes_df.bestLocus2Genes_symbol, bestgenes_df.variant_nearestCodingGene_symbol)]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 64,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "1467"
      ]
     },
     "execution_count": 64,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.variant_nearestCodingGene_id.isna().sum()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 65,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "958"
      ]
     },
     "execution_count": 65,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "nogenes = np.array([(len(x)==0) and y for x,y in zip(bestgenes_df.bestLocus2Genes_id, bestgenes_df.variant_nearestCodingGene_id.isna())])\n",
    "nogenes.sum()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 66,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(225064, 72)"
      ]
     },
     "execution_count": 66,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 67,
   "metadata": {},
   "outputs": [],
   "source": [
    "bestgenes_df = bestgenes_df[~nogenes]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 68,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(224106, 72)"
      ]
     },
     "execution_count": 68,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 69,
   "metadata": {},
   "outputs": [],
   "source": [
    "bestgenes_df.drop(columns=['bestGenes', 'bestColocGenes', 'bestLocus2Genes'], inplace=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "Index(['pvalMantissa', 'pvalExponent', 'credibleSetSize', 'ldSetSize',\n",
       "       'totalSetSize', 'pval', 'oddsRatio', 'oddsRatioCILower',\n",
       "       'oddsRatioCIUpper', 'beta', 'betaCILower', 'betaCIUpper', 'direction',\n",
       "       'variant_chromosome', 'variant_position', 'variant_refAllele',\n",
       "       'variant_altAllele', 'variant_rsId', 'variant_chromosomeB37',\n",
       "       'variant_positionB37', 'variant_id', 'variant_nearestGene',\n",
       "       'variant_nearestGeneDistance', 'variant_nearestCodingGene',\n",
       "       'variant_nearestCodingGeneDistance', 'variant_mostSevereConsequence',\n",
       "       'variant_caddRaw', 'variant_caddPhred', 'variant_gnomadAFR',\n",
       "       'variant_gnomadAMR', 'variant_gnomadASJ', 'variant_gnomadEAS',\n",
       "       'variant_gnomadFIN', 'variant_gnomadNFE', 'variant_gnomadNFEEST',\n",
       "       'variant_gnomadNFENWE', 'variant_gnomadNFESEU', 'variant_gnomadNFEONF',\n",
       "       'variant_gnomadOTH', 'study', 'variant_nearestGene_id',\n",
       "       'variant_nearestGene_symbol', 'variant_nearestGene_bioType',\n",
       "       'variant_nearestGene_description', 'variant_nearestGene_chromosome',\n",
       "       'variant_nearestGene_tss', 'variant_nearestGene_start',\n",
       "       'variant_nearestGene_end', 'variant_nearestGene_fwdStrand',\n",
       "       'variant_nearestGene_exons', 'variant_nearestCodingGene_id',\n",
       "       'variant_nearestCodingGene_symbol', 'variant_nearestCodingGene_bioType',\n",
       "       'variant_nearestCodingGene_description',\n",
       "       'variant_nearestCodingGene_chromosome', 'variant_nearestCodingGene_tss',\n",
       "       'variant_nearestCodingGene_start', 'variant_nearestCodingGene_end',\n",
       "       'variant_nearestCodingGene_fwdStrand',\n",
       "       'variant_nearestCodingGene_exons', 'bestGenes_id', 'bestGenes_symbol',\n",
       "       'bestColocGenes_id', 'bestColocGenes_symbol', 'bestLocus2Genes_id',\n",
       "       'bestLocus2Genes_symbol', 'bestLocus2Genes_score',\n",
       "       'bestLocus2GenesOrClosest_id', 'bestLocus2GenesOrClosest_symbol'],\n",
       "      dtype='object')"
      ]
     },
     "execution_count": 70,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.columns"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 71,
   "metadata": {},
   "outputs": [],
   "source": [
    "bestgenes_df = bestgenes_df[bestgenes_df.columns[-9:].tolist() + bestgenes_df.columns[:-9].tolist()].set_index('study').reset_index()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 72,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>study</th>\n",
       "      <th>bestGenes_id</th>\n",
       "      <th>bestGenes_symbol</th>\n",
       "      <th>bestColocGenes_id</th>\n",
       "      <th>bestColocGenes_symbol</th>\n",
       "      <th>bestLocus2Genes_id</th>\n",
       "      <th>bestLocus2Genes_symbol</th>\n",
       "      <th>bestLocus2Genes_score</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>pvalMantissa</th>\n",
       "      <th>pvalExponent</th>\n",
       "      <th>credibleSetSize</th>\n",
       "      <th>ldSetSize</th>\n",
       "      <th>totalSetSize</th>\n",
       "      <th>pval</th>\n",
       "      <th>oddsRatio</th>\n",
       "      <th>oddsRatioCILower</th>\n",
       "      <th>oddsRatioCIUpper</th>\n",
       "      <th>beta</th>\n",
       "      <th>betaCILower</th>\n",
       "      <th>betaCIUpper</th>\n",
       "      <th>direction</th>\n",
       "      <th>variant_chromosome</th>\n",
       "      <th>variant_position</th>\n",
       "      <th>variant_refAllele</th>\n",
       "      <th>variant_altAllele</th>\n",
       "      <th>variant_rsId</th>\n",
       "      <th>variant_chromosomeB37</th>\n",
       "      <th>variant_positionB37</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_nearestGene</th>\n",
       "      <th>variant_nearestGeneDistance</th>\n",
       "      <th>variant_nearestCodingGene</th>\n",
       "      <th>variant_nearestCodingGeneDistance</th>\n",
       "      <th>variant_mostSevereConsequence</th>\n",
       "      <th>variant_caddRaw</th>\n",
       "      <th>variant_caddPhred</th>\n",
       "      <th>variant_gnomadAFR</th>\n",
       "      <th>variant_gnomadAMR</th>\n",
       "      <th>variant_gnomadASJ</th>\n",
       "      <th>variant_gnomadEAS</th>\n",
       "      <th>variant_gnomadFIN</th>\n",
       "      <th>variant_gnomadNFE</th>\n",
       "      <th>variant_gnomadNFEEST</th>\n",
       "      <th>variant_gnomadNFENWE</th>\n",
       "      <th>variant_gnomadNFESEU</th>\n",
       "      <th>variant_gnomadNFEONF</th>\n",
       "      <th>variant_gnomadOTH</th>\n",
       "      <th>variant_nearestGene_id</th>\n",
       "      <th>variant_nearestGene_symbol</th>\n",
       "      <th>variant_nearestGene_bioType</th>\n",
       "      <th>variant_nearestGene_description</th>\n",
       "      <th>variant_nearestGene_chromosome</th>\n",
       "      <th>variant_nearestGene_tss</th>\n",
       "      <th>variant_nearestGene_start</th>\n",
       "      <th>variant_nearestGene_end</th>\n",
       "      <th>variant_nearestGene_fwdStrand</th>\n",
       "      <th>variant_nearestGene_exons</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>variant_nearestCodingGene_bioType</th>\n",
       "      <th>variant_nearestCodingGene_description</th>\n",
       "      <th>variant_nearestCodingGene_chromosome</th>\n",
       "      <th>variant_nearestCodingGene_tss</th>\n",
       "      <th>variant_nearestCodingGene_start</th>\n",
       "      <th>variant_nearestCodingGene_end</th>\n",
       "      <th>variant_nearestCodingGene_fwdStrand</th>\n",
       "      <th>variant_nearestCodingGene_exons</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>FINNGEN_R5_AB1_GHLAMY_OTHER</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(0.6906188130378723, 0.5723833441734314)</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>2.015</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>2.015000e-08</td>\n",
       "      <td>7938577976.443386</td>\n",
       "      <td>2763395.679138</td>\n",
       "      <td>22805644795582.570312</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>FINNGEN_R5_AB1_MEASLES</td>\n",
       "      <td>(ENSG00000273396, ENSG00000163132)</td>\n",
       "      <td>(LINC01396, MSX1)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "      <td>(0.6779915690422058,)</td>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "      <td>4.990</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>13</td>\n",
       "      <td>13</td>\n",
       "      <td>4.990000e-08</td>\n",
       "      <td>0.552501</td>\n",
       "      <td>0.446371</td>\n",
       "      <td>0.683865</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>4</td>\n",
       "      <td>4864861</td>\n",
       "      <td>A</td>\n",
       "      <td>C</td>\n",
       "      <td>rs6825765</td>\n",
       "      <td>4</td>\n",
       "      <td>4866588</td>\n",
       "      <td>4_4864861_A_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>downstream_gene_variant</td>\n",
       "      <td>0.129132</td>\n",
       "      <td>4.745</td>\n",
       "      <td>0.468369</td>\n",
       "      <td>0.612028</td>\n",
       "      <td>0.375862</td>\n",
       "      <td>0.652706</td>\n",
       "      <td>0.601729</td>\n",
       "      <td>0.464031</td>\n",
       "      <td>0.508534</td>\n",
       "      <td>0.448545</td>\n",
       "      <td>0.443396</td>\n",
       "      <td>0.432116</td>\n",
       "      <td>0.48893</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>(0.6587790846824646,)</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>6.133</td>\n",
       "      <td>-10</td>\n",
       "      <td>3</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>6.133000e-10</td>\n",
       "      <td>0.874765</td>\n",
       "      <td>0.838461</td>\n",
       "      <td>0.912641</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>159743672</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs74596724</td>\n",
       "      <td>1</td>\n",
       "      <td>159713462</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.770176</td>\n",
       "      <td>11.64</td>\n",
       "      <td>0.011703</td>\n",
       "      <td>0.040094</td>\n",
       "      <td>0.096552</td>\n",
       "      <td>0.164103</td>\n",
       "      <td>0.063364</td>\n",
       "      <td>0.075765</td>\n",
       "      <td>0.096288</td>\n",
       "      <td>0.067939</td>\n",
       "      <td>0.09434</td>\n",
       "      <td>0.062324</td>\n",
       "      <td>0.0625</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>(ENSG00000235532,)</td>\n",
       "      <td>(LINC00402,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000118922,)</td>\n",
       "      <td>(KLF12,)</td>\n",
       "      <td>(0.8585225939750671,)</td>\n",
       "      <td>(ENSG00000118922,)</td>\n",
       "      <td>(KLF12,)</td>\n",
       "      <td>4.023</td>\n",
       "      <td>-8</td>\n",
       "      <td>8</td>\n",
       "      <td>0</td>\n",
       "      <td>8</td>\n",
       "      <td>4.023000e-08</td>\n",
       "      <td>1.997507</td>\n",
       "      <td>1.560296</td>\n",
       "      <td>2.55723</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>13</td>\n",
       "      <td>74291635</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117832616</td>\n",
       "      <td>13</td>\n",
       "      <td>74865772</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>60178</td>\n",
       "      <td>NaN</td>\n",
       "      <td>296579</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.24534</td>\n",
       "      <td>0.528</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002358</td>\n",
       "      <td>0</td>\n",
       "      <td>0.010296</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.000519</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000935</td>\n",
       "      <td>0</td>\n",
       "      <td>ENSG00000235532</td>\n",
       "      <td>LINC00402</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 402 [So...</td>\n",
       "      <td>13</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74259976.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[74256933, 74259976, 74231457, 74231752]</td>\n",
       "      <td>ENSG00000118922</td>\n",
       "      <td>KLF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Kruppel like factor 12 [Source:HGNC Symbol;Acc...</td>\n",
       "      <td>13</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>73686089.0</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[73686089, 73695671, 73715368, 73715525, 73764...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_CHLAMYDIAE</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(0.6522198915481567, 0.568143904209137)</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>1.552</td>\n",
       "      <td>-9</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>1.552000e-09</td>\n",
       "      <td>20134487948.29578</td>\n",
       "      <td>9112823.906844</td>\n",
       "      <td>44486496072376.03125</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_SPIROCHAETAL</td>\n",
       "      <td>(ENSG00000135316,)</td>\n",
       "      <td>(SYNCRIP,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000135316,)</td>\n",
       "      <td>(SYNCRIP,)</td>\n",
       "      <td>4.612</td>\n",
       "      <td>-8</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>4.612000e-08</td>\n",
       "      <td>2.967738</td>\n",
       "      <td>2.009148</td>\n",
       "      <td>4.383682</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>86087207</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>rs184239803</td>\n",
       "      <td>6</td>\n",
       "      <td>86796925</td>\n",
       "      <td>6_86087207_T_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>443415</td>\n",
       "      <td>NaN</td>\n",
       "      <td>443415</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.082352</td>\n",
       "      <td>1.574</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.016983</td>\n",
       "      <td>0.003953</td>\n",
       "      <td>0.010235</td>\n",
       "      <td>0.00093</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002809</td>\n",
       "      <td>0.008287</td>\n",
       "      <td>ENSG00000135316</td>\n",
       "      <td>SYNCRIP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>synaptotagmin binding cytoplasmic RNA interact...</td>\n",
       "      <td>6</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>85607785.0</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[85636967, 85637143, 85614106, 85615347, 85618...</td>\n",
       "      <td>ENSG00000135316</td>\n",
       "      <td>SYNCRIP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>synaptotagmin binding cytoplasmic RNA interact...</td>\n",
       "      <td>6</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>85607785.0</td>\n",
       "      <td>85643792.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[85636967, 85637143, 85614106, 85615347, 85618...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_VIRAL</td>\n",
       "      <td>(ENSG00000224028,)</td>\n",
       "      <td>(LINC01853,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000168702,)</td>\n",
       "      <td>(LRP1B,)</td>\n",
       "      <td>(0.806581974029541,)</td>\n",
       "      <td>(ENSG00000168702,)</td>\n",
       "      <td>(LRP1B,)</td>\n",
       "      <td>2.698</td>\n",
       "      <td>-8</td>\n",
       "      <td>6</td>\n",
       "      <td>0</td>\n",
       "      <td>6</td>\n",
       "      <td>2.698000e-08</td>\n",
       "      <td>1.431897</td>\n",
       "      <td>1.261682</td>\n",
       "      <td>1.625075</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>2</td>\n",
       "      <td>140392828</td>\n",
       "      <td>A</td>\n",
       "      <td>C</td>\n",
       "      <td>rs115342755</td>\n",
       "      <td>2</td>\n",
       "      <td>141150397</td>\n",
       "      <td>2_140392828_A_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>261048</td>\n",
       "      <td>NaN</td>\n",
       "      <td>1612438</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>-0.025799</td>\n",
       "      <td>2.25</td>\n",
       "      <td>0.004705</td>\n",
       "      <td>0.016548</td>\n",
       "      <td>0.006897</td>\n",
       "      <td>0</td>\n",
       "      <td>0.022229</td>\n",
       "      <td>0.026797</td>\n",
       "      <td>0.030773</td>\n",
       "      <td>0.026199</td>\n",
       "      <td>0.009434</td>\n",
       "      <td>0.021536</td>\n",
       "      <td>0.024862</td>\n",
       "      <td>ENSG00000224028</td>\n",
       "      <td>LINC01853</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 1853 [S...</td>\n",
       "      <td>2</td>\n",
       "      <td>140131780.0</td>\n",
       "      <td>140103583.0</td>\n",
       "      <td>140131780.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[140103583, 140103770, 140114042, 140114104, 1...</td>\n",
       "      <td>ENSG00000144227</td>\n",
       "      <td>NXPH2</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>neurexophilin 2 [Source:HGNC Symbol;Acc:HGNC:8...</td>\n",
       "      <td>2</td>\n",
       "      <td>138780390.0</td>\n",
       "      <td>138669157.0</td>\n",
       "      <td>138780390.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[138669157, 138671665, 138780191, 138780390]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>FINNGEN_R5_AB1_PARASITIC_NOS</td>\n",
       "      <td>(ENSG00000257262,)</td>\n",
       "      <td>(AC023511.1,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000133687,)</td>\n",
       "      <td>(TMTC1,)</td>\n",
       "      <td>2.848</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>2.848000e-08</td>\n",
       "      <td>3007281914075618229259429730360229888.0</td>\n",
       "      <td>395407566600420796137472.0</td>\n",
       "      <td>2287195611475354555411830694106492820151831049...</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>12</td>\n",
       "      <td>30229782</td>\n",
       "      <td>C</td>\n",
       "      <td>A</td>\n",
       "      <td>rs193152916</td>\n",
       "      <td>12</td>\n",
       "      <td>30382715</td>\n",
       "      <td>12_30229782_C_A</td>\n",
       "      <td>NaN</td>\n",
       "      <td>28799</td>\n",
       "      <td>NaN</td>\n",
       "      <td>445023</td>\n",
       "      <td>downstream_gene_variant</td>\n",
       "      <td>-0.043819</td>\n",
       "      <td>2.013</td>\n",
       "      <td>0.001148</td>\n",
       "      <td>0.008274</td>\n",
       "      <td>0.034483</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.00389</td>\n",
       "      <td>0.001743</td>\n",
       "      <td>0.00419</td>\n",
       "      <td>0.009434</td>\n",
       "      <td>0.007022</td>\n",
       "      <td>0.003683</td>\n",
       "      <td>ENSG00000257262</td>\n",
       "      <td>AC023511.1</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>novel transcript</td>\n",
       "      <td>12</td>\n",
       "      <td>30200983.0</td>\n",
       "      <td>30200983.0</td>\n",
       "      <td>30217916.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[30217603, 30217916, 30208442, 30208572, 30200...</td>\n",
       "      <td>ENSG00000133687</td>\n",
       "      <td>TMTC1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>transmembrane and tetratricopeptide repeat con...</td>\n",
       "      <td>12</td>\n",
       "      <td>29784759.0</td>\n",
       "      <td>29500840.0</td>\n",
       "      <td>29784759.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[29512043, 29512120, 29500840, 29506986, 29514...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>FINNGEN_R5_AB1_SEPSIS</td>\n",
       "      <td>(ENSG00000248701,)</td>\n",
       "      <td>(AC008539.1,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000127184,)</td>\n",
       "      <td>(COX7C,)</td>\n",
       "      <td>2.651</td>\n",
       "      <td>-8</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>2.651000e-08</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>0.9322</td>\n",
       "      <td>0.603763</td>\n",
       "      <td>1.260637</td>\n",
       "      <td>+</td>\n",
       "      <td>5</td>\n",
       "      <td>86841238</td>\n",
       "      <td>A</td>\n",
       "      <td>T</td>\n",
       "      <td>rs189334156</td>\n",
       "      <td>5</td>\n",
       "      <td>86137055</td>\n",
       "      <td>5_86841238_A_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>43553</td>\n",
       "      <td>NaN</td>\n",
       "      <td>223310</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>1.663021</td>\n",
       "      <td>16.58</td>\n",
       "      <td>0.00195</td>\n",
       "      <td>0.002364</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.002301</td>\n",
       "      <td>0.008557</td>\n",
       "      <td>0.005009</td>\n",
       "      <td>0.010009</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.010768</td>\n",
       "      <td>0.004596</td>\n",
       "      <td>ENSG00000248701</td>\n",
       "      <td>AC008539.1</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>novel transcript</td>\n",
       "      <td>5</td>\n",
       "      <td>86797685.0</td>\n",
       "      <td>86797685.0</td>\n",
       "      <td>86800280.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[86799953, 86800280, 86797685, 86797838]</td>\n",
       "      <td>ENSG00000127184</td>\n",
       "      <td>COX7C</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>cytochrome c oxidase subunit 7C [Source:HGNC S...</td>\n",
       "      <td>5</td>\n",
       "      <td>86617928.0</td>\n",
       "      <td>86617928.0</td>\n",
       "      <td>86620962.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[86619353, 86620761, 86617956, 86618130]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>FINNGEN_R5_AB1_VARICELLA</td>\n",
       "      <td>(ENSG00000189079,)</td>\n",
       "      <td>(ARID2,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000189079,)</td>\n",
       "      <td>(ARID2,)</td>\n",
       "      <td>(0.8285683393478394,)</td>\n",
       "      <td>(ENSG00000189079,)</td>\n",
       "      <td>(ARID2,)</td>\n",
       "      <td>3.349</td>\n",
       "      <td>-8</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>3.349000e-08</td>\n",
       "      <td>22.102705</td>\n",
       "      <td>7.366391</td>\n",
       "      <td>66.318711</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>12</td>\n",
       "      <td>45880832</td>\n",
       "      <td>A</td>\n",
       "      <td>T</td>\n",
       "      <td>rs534784995</td>\n",
       "      <td>12</td>\n",
       "      <td>46274615</td>\n",
       "      <td>12_45880832_A_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>91643</td>\n",
       "      <td>NaN</td>\n",
       "      <td>111288</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>1.32566</td>\n",
       "      <td>15.04</td>\n",
       "      <td>0.000344</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.010345</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.004018</td>\n",
       "      <td>0.007622</td>\n",
       "      <td>0.002094</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.004213</td>\n",
       "      <td>0.003676</td>\n",
       "      <td>ENSG00000278475</td>\n",
       "      <td>AC009464.1</td>\n",
       "      <td>sense_intronic</td>\n",
       "      <td>novel transcript, sense intronic to ARID2</td>\n",
       "      <td>12</td>\n",
       "      <td>45789189.0</td>\n",
       "      <td>45789189.0</td>\n",
       "      <td>45789657.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[45789189, 45789657]</td>\n",
       "      <td>ENSG00000139218</td>\n",
       "      <td>SCAF11</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>SR-related CTD associated factor 11 [Source:HG...</td>\n",
       "      <td>12</td>\n",
       "      <td>45992120.0</td>\n",
       "      <td>45919131.0</td>\n",
       "      <td>45992120.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[45934447, 45934505, 45945249, 45945313, 45919...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                               study                        bestGenes_id  \\\n",
       "0        FINNGEN_R5_AB1_GHLAMY_OTHER                                  ()   \n",
       "1             FINNGEN_R5_AB1_MEASLES  (ENSG00000273396, ENSG00000163132)   \n",
       "2     FINNGEN_R5_AB1_OTHER_BACTERIAL                  (ENSG00000132693,)   \n",
       "3     FINNGEN_R5_AB1_OTHER_BACTERIAL                  (ENSG00000235532,)   \n",
       "4    FINNGEN_R5_AB1_OTHER_CHLAMYDIAE                                  ()   \n",
       "5  FINNGEN_R5_AB1_OTHER_SPIROCHAETAL                  (ENSG00000135316,)   \n",
       "6         FINNGEN_R5_AB1_OTHER_VIRAL                  (ENSG00000224028,)   \n",
       "7       FINNGEN_R5_AB1_PARASITIC_NOS                  (ENSG00000257262,)   \n",
       "8              FINNGEN_R5_AB1_SEPSIS                  (ENSG00000248701,)   \n",
       "9           FINNGEN_R5_AB1_VARICELLA                  (ENSG00000189079,)   \n",
       "\n",
       "    bestGenes_symbol bestColocGenes_id bestColocGenes_symbol  \\\n",
       "0                 ()                ()                    ()   \n",
       "1  (LINC01396, MSX1)                ()                    ()   \n",
       "2             (CRP,)                ()                    ()   \n",
       "3       (LINC00402,)                ()                    ()   \n",
       "4                 ()                ()                    ()   \n",
       "5         (SYNCRIP,)                ()                    ()   \n",
       "6       (LINC01853,)                ()                    ()   \n",
       "7      (AC023511.1,)                ()                    ()   \n",
       "8      (AC008539.1,)                ()                    ()   \n",
       "9           (ARID2,)                ()                    ()   \n",
       "\n",
       "                   bestLocus2Genes_id bestLocus2Genes_symbol  \\\n",
       "0  (ENSG00000112818, ENSG00000069122)        (MEP1A, ADGRF5)   \n",
       "1                  (ENSG00000163132,)                (MSX1,)   \n",
       "2                  (ENSG00000132693,)                 (CRP,)   \n",
       "3                  (ENSG00000118922,)               (KLF12,)   \n",
       "4  (ENSG00000112818, ENSG00000069122)        (MEP1A, ADGRF5)   \n",
       "5                                  ()                     ()   \n",
       "6                  (ENSG00000168702,)               (LRP1B,)   \n",
       "7                                  ()                     ()   \n",
       "8                                  ()                     ()   \n",
       "9                  (ENSG00000189079,)               (ARID2,)   \n",
       "\n",
       "                      bestLocus2Genes_score  \\\n",
       "0  (0.6906188130378723, 0.5723833441734314)   \n",
       "1                     (0.6779915690422058,)   \n",
       "2                     (0.6587790846824646,)   \n",
       "3                     (0.8585225939750671,)   \n",
       "4   (0.6522198915481567, 0.568143904209137)   \n",
       "5                                        ()   \n",
       "6                      (0.806581974029541,)   \n",
       "7                                        ()   \n",
       "8                                        ()   \n",
       "9                     (0.8285683393478394,)   \n",
       "\n",
       "          bestLocus2GenesOrClosest_id bestLocus2GenesOrClosest_symbol  \\\n",
       "0  (ENSG00000112818, ENSG00000069122)                 (MEP1A, ADGRF5)   \n",
       "1                  (ENSG00000163132,)                         (MSX1,)   \n",
       "2                  (ENSG00000132693,)                          (CRP,)   \n",
       "3                  (ENSG00000118922,)                        (KLF12,)   \n",
       "4  (ENSG00000112818, ENSG00000069122)                 (MEP1A, ADGRF5)   \n",
       "5                  (ENSG00000135316,)                      (SYNCRIP,)   \n",
       "6                  (ENSG00000168702,)                        (LRP1B,)   \n",
       "7                  (ENSG00000133687,)                        (TMTC1,)   \n",
       "8                  (ENSG00000127184,)                        (COX7C,)   \n",
       "9                  (ENSG00000189079,)                        (ARID2,)   \n",
       "\n",
       "   pvalMantissa  pvalExponent  credibleSetSize  ldSetSize  totalSetSize  \\\n",
       "0         2.015            -8                2          0             2   \n",
       "1         4.990            -8                2         13            13   \n",
       "2         6.133           -10                3          4             4   \n",
       "3         4.023            -8                8          0             8   \n",
       "4         1.552            -9                2          0             2   \n",
       "5         4.612            -8                3          0             3   \n",
       "6         2.698            -8                6          0             6   \n",
       "7         2.848            -8                2          0             2   \n",
       "8         2.651            -8                1          0             1   \n",
       "9         3.349            -8                3          0             3   \n",
       "\n",
       "           pval                                oddsRatio  \\\n",
       "0  2.015000e-08                        7938577976.443386   \n",
       "1  4.990000e-08                                 0.552501   \n",
       "2  6.133000e-10                                 0.874765   \n",
       "3  4.023000e-08                                 1.997507   \n",
       "4  1.552000e-09                        20134487948.29578   \n",
       "5  4.612000e-08                                 2.967738   \n",
       "6  2.698000e-08                                 1.431897   \n",
       "7  2.848000e-08  3007281914075618229259429730360229888.0   \n",
       "8  2.651000e-08                                     None   \n",
       "9  3.349000e-08                                22.102705   \n",
       "\n",
       "             oddsRatioCILower  \\\n",
       "0              2763395.679138   \n",
       "1                    0.446371   \n",
       "2                    0.838461   \n",
       "3                    1.560296   \n",
       "4              9112823.906844   \n",
       "5                    2.009148   \n",
       "6                    1.261682   \n",
       "7  395407566600420796137472.0   \n",
       "8                        None   \n",
       "9                    7.366391   \n",
       "\n",
       "                                    oddsRatioCIUpper    beta betaCILower  \\\n",
       "0                              22805644795582.570312    None        None   \n",
       "1                                           0.683865    None        None   \n",
       "2                                           0.912641    None        None   \n",
       "3                                            2.55723    None        None   \n",
       "4                               44486496072376.03125    None        None   \n",
       "5                                           4.383682    None        None   \n",
       "6                                           1.625075    None        None   \n",
       "7  2287195611475354555411830694106492820151831049...    None        None   \n",
       "8                                               None  0.9322    0.603763   \n",
       "9                                          66.318711    None        None   \n",
       "\n",
       "  betaCIUpper direction variant_chromosome  variant_position  \\\n",
       "0        None         +                  6          46877116   \n",
       "1        None         -                  4           4864861   \n",
       "2        None         -                  1         159743672   \n",
       "3        None         +                 13          74291635   \n",
       "4        None         +                  6          46877116   \n",
       "5        None         +                  6          86087207   \n",
       "6        None         +                  2         140392828   \n",
       "7        None         +                 12          30229782   \n",
       "8    1.260637         +                  5          86841238   \n",
       "9        None         +                 12          45880832   \n",
       "\n",
       "  variant_refAllele variant_altAllele variant_rsId variant_chromosomeB37  \\\n",
       "0                 T                 G         None                  None   \n",
       "1                 A                 C    rs6825765                     4   \n",
       "2                 A                 G   rs74596724                     1   \n",
       "3                 C                 T  rs117832616                    13   \n",
       "4                 T                 G         None                  None   \n",
       "5                 T                 C  rs184239803                     6   \n",
       "6                 A                 C  rs115342755                     2   \n",
       "7                 C                 A  rs193152916                    12   \n",
       "8                 A                 T  rs189334156                     5   \n",
       "9                 A                 T  rs534784995                    12   \n",
       "\n",
       "  variant_positionB37       variant_id variant_nearestGene  \\\n",
       "0                None   6_46877116_T_G                None   \n",
       "1             4866588    4_4864861_A_C                 NaN   \n",
       "2           159713462  1_159743672_A_G                 NaN   \n",
       "3            74865772  13_74291635_C_T                 NaN   \n",
       "4                None   6_46877116_T_G                None   \n",
       "5            86796925   6_86087207_T_C                 NaN   \n",
       "6           141150397  2_140392828_A_C                 NaN   \n",
       "7            30382715  12_30229782_C_A                 NaN   \n",
       "8            86137055   5_86841238_A_T                 NaN   \n",
       "9            46274615  12_45880832_A_T                 NaN   \n",
       "\n",
       "  variant_nearestGeneDistance variant_nearestCodingGene  \\\n",
       "0                        None                      None   \n",
       "1                        5196                       NaN   \n",
       "2                       29083                       NaN   \n",
       "3                       60178                       NaN   \n",
       "4                        None                      None   \n",
       "5                      443415                       NaN   \n",
       "6                      261048                       NaN   \n",
       "7                       28799                       NaN   \n",
       "8                       43553                       NaN   \n",
       "9                       91643                       NaN   \n",
       "\n",
       "  variant_nearestCodingGeneDistance variant_mostSevereConsequence  \\\n",
       "0                              None                          None   \n",
       "1                              5196       downstream_gene_variant   \n",
       "2                             29083            intergenic_variant   \n",
       "3                            296579         upstream_gene_variant   \n",
       "4                              None                          None   \n",
       "5                            443415         upstream_gene_variant   \n",
       "6                           1612438                intron_variant   \n",
       "7                            445023       downstream_gene_variant   \n",
       "8                            223310            intergenic_variant   \n",
       "9                            111288                intron_variant   \n",
       "\n",
       "  variant_caddRaw variant_caddPhred variant_gnomadAFR variant_gnomadAMR  \\\n",
       "0            None              None              None              None   \n",
       "1        0.129132             4.745          0.468369          0.612028   \n",
       "2        0.770176             11.64          0.011703          0.040094   \n",
       "3        -0.24534             0.528                 0          0.002358   \n",
       "4            None              None              None              None   \n",
       "5       -0.082352             1.574                 0                 0   \n",
       "6       -0.025799              2.25          0.004705          0.016548   \n",
       "7       -0.043819             2.013          0.001148          0.008274   \n",
       "8        1.663021             16.58           0.00195          0.002364   \n",
       "9         1.32566             15.04          0.000344               0.0   \n",
       "\n",
       "  variant_gnomadASJ variant_gnomadEAS variant_gnomadFIN variant_gnomadNFE  \\\n",
       "0              None              None              None              None   \n",
       "1          0.375862          0.652706          0.601729          0.464031   \n",
       "2          0.096552          0.164103          0.063364          0.075765   \n",
       "3                 0          0.010296          0.003165          0.000519   \n",
       "4              None              None              None              None   \n",
       "5                 0                 0          0.016983          0.003953   \n",
       "6          0.006897                 0          0.022229          0.026797   \n",
       "7          0.034483               0.0               0.0           0.00389   \n",
       "8               0.0               0.0          0.002301          0.008557   \n",
       "9          0.010345               0.0          0.003165          0.004018   \n",
       "\n",
       "  variant_gnomadNFEEST variant_gnomadNFENWE variant_gnomadNFESEU  \\\n",
       "0                 None                 None                 None   \n",
       "1             0.508534             0.448545             0.443396   \n",
       "2             0.096288             0.067939              0.09434   \n",
       "3             0.001093             0.000116                    0   \n",
       "4                 None                 None                 None   \n",
       "5             0.010235              0.00093                    0   \n",
       "6             0.030773             0.026199             0.009434   \n",
       "7             0.001743              0.00419             0.009434   \n",
       "8             0.005009             0.010009                  0.0   \n",
       "9             0.007622             0.002094                  0.0   \n",
       "\n",
       "  variant_gnomadNFEONF variant_gnomadOTH variant_nearestGene_id  \\\n",
       "0                 None              None                    NaN   \n",
       "1             0.432116           0.48893        ENSG00000163132   \n",
       "2             0.062324            0.0625        ENSG00000132693   \n",
       "3             0.000935                 0        ENSG00000235532   \n",
       "4                 None              None                    NaN   \n",
       "5             0.002809          0.008287        ENSG00000135316   \n",
       "6             0.021536          0.024862        ENSG00000224028   \n",
       "7             0.007022          0.003683        ENSG00000257262   \n",
       "8             0.010768          0.004596        ENSG00000248701   \n",
       "9             0.004213          0.003676        ENSG00000278475   \n",
       "\n",
       "  variant_nearestGene_symbol variant_nearestGene_bioType  \\\n",
       "0                        NaN                         NaN   \n",
       "1                       MSX1              protein_coding   \n",
       "2                        CRP              protein_coding   \n",
       "3                  LINC00402                     lincRNA   \n",
       "4                        NaN                         NaN   \n",
       "5                    SYNCRIP              protein_coding   \n",
       "6                  LINC01853                     lincRNA   \n",
       "7                 AC023511.1                     lincRNA   \n",
       "8                 AC008539.1                     lincRNA   \n",
       "9                 AC009464.1              sense_intronic   \n",
       "\n",
       "                     variant_nearestGene_description  \\\n",
       "0                                                NaN   \n",
       "1  msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "2  C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "3  long intergenic non-protein coding RNA 402 [So...   \n",
       "4                                                NaN   \n",
       "5  synaptotagmin binding cytoplasmic RNA interact...   \n",
       "6  long intergenic non-protein coding RNA 1853 [S...   \n",
       "7                                   novel transcript   \n",
       "8                                   novel transcript   \n",
       "9          novel transcript, sense intronic to ARID2   \n",
       "\n",
       "  variant_nearestGene_chromosome  variant_nearestGene_tss  \\\n",
       "0                            NaN                      NaN   \n",
       "1                              4                4859665.0   \n",
       "2                              1              159714589.0   \n",
       "3                             13               74231457.0   \n",
       "4                            NaN                      NaN   \n",
       "5                              6               85643792.0   \n",
       "6                              2              140131780.0   \n",
       "7                             12               30200983.0   \n",
       "8                              5               86797685.0   \n",
       "9                             12               45789189.0   \n",
       "\n",
       "   variant_nearestGene_start  variant_nearestGene_end  \\\n",
       "0                        NaN                      NaN   \n",
       "1                  4859665.0                4863936.0   \n",
       "2                159712289.0              159714589.0   \n",
       "3                 74231457.0               74259976.0   \n",
       "4                        NaN                      NaN   \n",
       "5                 85607785.0               85643792.0   \n",
       "6                140103583.0              140131780.0   \n",
       "7                 30200983.0               30217916.0   \n",
       "8                 86797685.0               86800280.0   \n",
       "9                 45789189.0               45789657.0   \n",
       "\n",
       "  variant_nearestGene_fwdStrand  \\\n",
       "0                           NaN   \n",
       "1                          True   \n",
       "2                         False   \n",
       "3                          True   \n",
       "4                           NaN   \n",
       "5                         False   \n",
       "6                         False   \n",
       "7                          True   \n",
       "8                          True   \n",
       "9                          True   \n",
       "\n",
       "                           variant_nearestGene_exons  \\\n",
       "0                                                NaN   \n",
       "1               [4862701, 4863936, 4859665, 4860368]   \n",
       "2       [159714425, 159714589, 159712289, 159714138]   \n",
       "3           [74256933, 74259976, 74231457, 74231752]   \n",
       "4                                                NaN   \n",
       "5  [85636967, 85637143, 85614106, 85615347, 85618...   \n",
       "6  [140103583, 140103770, 140114042, 140114104, 1...   \n",
       "7  [30217603, 30217916, 30208442, 30208572, 30200...   \n",
       "8           [86799953, 86800280, 86797685, 86797838]   \n",
       "9                               [45789189, 45789657]   \n",
       "\n",
       "  variant_nearestCodingGene_id variant_nearestCodingGene_symbol  \\\n",
       "0                          NaN                              NaN   \n",
       "1              ENSG00000163132                             MSX1   \n",
       "2              ENSG00000132693                              CRP   \n",
       "3              ENSG00000118922                            KLF12   \n",
       "4                          NaN                              NaN   \n",
       "5              ENSG00000135316                          SYNCRIP   \n",
       "6              ENSG00000144227                            NXPH2   \n",
       "7              ENSG00000133687                            TMTC1   \n",
       "8              ENSG00000127184                            COX7C   \n",
       "9              ENSG00000139218                           SCAF11   \n",
       "\n",
       "  variant_nearestCodingGene_bioType  \\\n",
       "0                               NaN   \n",
       "1                    protein_coding   \n",
       "2                    protein_coding   \n",
       "3                    protein_coding   \n",
       "4                               NaN   \n",
       "5                    protein_coding   \n",
       "6                    protein_coding   \n",
       "7                    protein_coding   \n",
       "8                    protein_coding   \n",
       "9                    protein_coding   \n",
       "\n",
       "               variant_nearestCodingGene_description  \\\n",
       "0                                                NaN   \n",
       "1  msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "2  C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "3  Kruppel like factor 12 [Source:HGNC Symbol;Acc...   \n",
       "4                                                NaN   \n",
       "5  synaptotagmin binding cytoplasmic RNA interact...   \n",
       "6  neurexophilin 2 [Source:HGNC Symbol;Acc:HGNC:8...   \n",
       "7  transmembrane and tetratricopeptide repeat con...   \n",
       "8  cytochrome c oxidase subunit 7C [Source:HGNC S...   \n",
       "9  SR-related CTD associated factor 11 [Source:HG...   \n",
       "\n",
       "  variant_nearestCodingGene_chromosome  variant_nearestCodingGene_tss  \\\n",
       "0                                  NaN                            NaN   \n",
       "1                                    4                      4859665.0   \n",
       "2                                    1                    159714589.0   \n",
       "3                                   13                     73995056.0   \n",
       "4                                  NaN                            NaN   \n",
       "5                                    6                     85643792.0   \n",
       "6                                    2                    138780390.0   \n",
       "7                                   12                     29784759.0   \n",
       "8                                    5                     86617928.0   \n",
       "9                                   12                     45992120.0   \n",
       "\n",
       "   variant_nearestCodingGene_start  variant_nearestCodingGene_end  \\\n",
       "0                              NaN                            NaN   \n",
       "1                        4859665.0                      4863936.0   \n",
       "2                      159712289.0                    159714589.0   \n",
       "3                       73686089.0                     73995056.0   \n",
       "4                              NaN                            NaN   \n",
       "5                       85607785.0                     85643792.0   \n",
       "6                      138669157.0                    138780390.0   \n",
       "7                       29500840.0                     29784759.0   \n",
       "8                       86617928.0                     86620962.0   \n",
       "9                       45919131.0                     45992120.0   \n",
       "\n",
       "  variant_nearestCodingGene_fwdStrand  \\\n",
       "0                                 NaN   \n",
       "1                                True   \n",
       "2                               False   \n",
       "3                               False   \n",
       "4                                 NaN   \n",
       "5                               False   \n",
       "6                               False   \n",
       "7                               False   \n",
       "8                                True   \n",
       "9                               False   \n",
       "\n",
       "                     variant_nearestCodingGene_exons  \n",
       "0                                                NaN  \n",
       "1               [4862701, 4863936, 4859665, 4860368]  \n",
       "2       [159714425, 159714589, 159712289, 159714138]  \n",
       "3  [73686089, 73695671, 73715368, 73715525, 73764...  \n",
       "4                                                NaN  \n",
       "5  [85636967, 85637143, 85614106, 85615347, 85618...  \n",
       "6       [138669157, 138671665, 138780191, 138780390]  \n",
       "7  [29512043, 29512120, 29500840, 29506986, 29514...  \n",
       "8           [86619353, 86620761, 86617956, 86618130]  \n",
       "9  [45934447, 45934505, 45945249, 45945313, 45919...  "
      ]
     },
     "execution_count": 72,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.head(10)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Fun exercise with L2G distribution"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 73,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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3cZyXVdXXq+quqrqjqi6tquO2UX+vqjqrqq6vqnur6ntV9YmqOmQW1w0AAOvZrEb235hk7yRfSPK+JP8lyX1JzkxyTVU9brpyVZ2Q5LIkRyb5ZJIPJNk9yXuSbJzvAFV1TpLzkuyf5MNJPp7k0CSfrqpT5qm/x3g+b09y53heX0zywiRXVtWzVnC9AACw7u02o372aa3dO3djVb0zyW8l+b+T/Otx2z4Zwvr9SZ7TWrty3P62JJckObGqTm6tbZzq5/Akpya5KckzW2s/GLe/O8lVSc6pqotaa5unDv+mJEck2ZTkxa21B8Y2FyS5MMlHqurQyXYAAOjNTEb25wv6o0+M5ROntp2Y5FFJNk6C/lQfbx1/fM2cfl49lu+cBP2xzeYMfxXYI8nLJ9urqqbavGU60LfWPpXkq0menOSo7V0bAADsrFb7Ad1fHstrprYdPZafm6f+ZUnuSXL4OA1nMW0+O6dOkhyY5PFJbmit3bLINvOqqqvm+yR50vbaAgDAWprVNJ4kSVW9OclDk+yb5BlJfj5D0D97qtrBY3nD3Pattfuq6pYkT0nyhCTXVdXeSR6b5K7W2q3zHPbGsTxoMcfYRhsAAOjKTMN+kjcn+UdTP38uya+31v7n1LZ9x/KOBfqYbH/4Musvt828WmuHzbd9HN1/+vbaAwDAWpnpNJ7W2mNaa5XkMUl+JcPo/J9X1VJCcU26W+rhd8AxAABgp7Eqc/Zba3/bWvtkkl9K8sgkfzi1ezKqvu+PNRzsM6fe9urPN4q/1GMAAEB3VvUB3dbaXyW5NslTquonx83Xj+WPzZevqt2SHJBhjf6bxz7uTvKdJA+tqv3nOcxkpZ/p+fkLHmMbbQAAoCurvRpPkvwfY3n/WF4ylsfMU/fIJA9JcnlrbevU9m21ed6cOsmwHv+3khxUVQcssg0AAHRlxWG/qp5UVY+ZZ/uDxpdqPTpDeJ+sj78pyW1JTq6qZ0zV3zPJO8YfPzinuw+N5elV9YipNhuSvDbJ1iQfnWxvrbWpNu+qqgdNtTkhybMz/MXhK0u7WgAA2HnMYjWeY5K8u6ouyzCi/v0MK/IcleEB3e8meeWkcmvtzqp6ZYbQf2lVbUxye5LjMyyZuSnJBdMHaK1dXlXnZngr7jVVtSnJ7klenGS/JK+b8/bcJDk3yXEZXuJ1RVV9KcPa+ydlWMv/Fd6eCwBAz2YR9r+Y5D8lOSLJz2RYzvLuDPPhP5bk/a2126cbtNYurKqjkpye5EVJ9kzyzQxh/v3jyHzmtDm1qq5JckqSVyV5IMnVSd7dWrtonvpbq+q5SU5L8pIkb0xyZ5ILk5zRWrt2xVcOAADr2IrDfmvtGxmm0iy13deSPH+Jbc5Pcv4S6m9Jcsb4AQCAXcqOeEAXAABYA8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0asVhv6oeWVW/UVWfrKpvVtWWqrqjqv6kqv5lVc17jKo6vKourqrbq+qeqrqmqt5QVQ/exrFeVlVfr6q7xmNcWlXHbaP+XlV1VlVdX1X3VtX3quoTVXXISq8bAADWu1mM7J+U5MNJnpXkiiTvTfJHSX46yX9O8omqqukGVXVCksuSHJnkk0k+kGT3JO9JsnG+g1TVOUnOS7L/eLyPJzk0yaer6pR56u+R5AtJ3p7kziTvS/LFJC9McmVVPWv5lwwAAOvfbjPo44Ykxyf5TGvtgcnGqvqtJF9P8qIkv5LhF4BU1T4Zwvr9SZ7TWrty3P62JJckObGqTm6tbZzq6/Akpya5KckzW2s/GLe/O8lVSc6pqotaa5unzutNSY5IsinJiyfnVlUXJLkwyUeq6tDpcwYAgJ6seGS/tXZJa+3Tc0Nza+27ST40/vicqV0nJnlUko2ToD/WvzfJW8cfXzPnMK8ey3dOgv7YZnOGvwrskeTlk+3jXxImbd4yfW6ttU8l+WqSJyc5atEXCgAAO5nVfkD378fyvqltR4/l5+apf1mSe5IcPk7DWUybz86pkyQHJnl8khtaa7csss28quqq+T5JnrS9tgAAsJZWLexX1W5Jfm38cTqkHzyWN8xt01q7L8ktGaYXPWHsZ+8kj01yV2vt1nkOdeNYHrSYY2yjDQAAdGUWc/YXcnaGh3Qvbq398dT2fcfyjgXaTbY/fJn1l9tmXq21w+bbPo7uP3177QEAYK2sysh+Vb0+wwO1f5nkpUttPpZtie2WUn+5xwAAgJ3GzMN+Vb02wzKX1yb5hdba7XOqTEbV98389plTb3v15xvFX+oxAACgOzMN+1X1hiS/l+QbGYL+d+epdv1Y/th8+XGe/wEZHui9OUlaa3cn+U6Sh1bV/vP098SxnJ6fv+AxttEGAAC6MrOwX1W/meGlWP89Q9D/3gJVLxnLY+bZd2SShyS5vLW2dZFtnjenTjKsx/+tJAdV1QGLbAMAAF2ZSdgfX4h1doYXXP1ia+22bVTflOS2JCdX1TOm+tgzyTvGHz84p81kvf7Tq+oRU202JHltkq1JPjrZ3lprU23eVVUPmmpzQpJnZ5hm9JVFXiIAAOx0VrwaT1W9LMlvZ3gj7leTvH54p9U/sLm1dl6StNburKpXZgj9l1bVxiS3Z3gL78Hj9gumG7fWLq+qczO8FfeaqtqUZPckL06yX5LXzXl7bpKcm+S4DC/xuqKqvpRh7f2TMqzl/wpvzwUAoGezWHpzMk3mwUnesECdryQ5b/JDa+3CqjoqyelJXpRkzyTfzBDm3z+OzP8DrbVTq+qaJKckeVWSB5JcneTdrbWL5qm/taqem+S0JC9J8sYkdya5MMkZrbVrl3qhAACwM1lx2G+tnZnkzGW0+1qS5y+xzflJzl9C/S1Jzhg/AACwS1m1N+gCAABrS9gHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU7ut9QkAAECSbDjtMzPtb/PZx860v52RkX0AAOiUsA8AAJ0S9gEAoFPCPgAAdErYBwCATgn7AADQKWEfAAA6JewDAECnhH0AAOiUsA8AAJ0S9gEAoFPCPgAAdErYBwCATgn7AADQKWEfAAA6JewDAECnhH0AAOiUsA8AAJ0S9gEAoFPCPgAAdErYBwCATgn7AADQKWEfAAA6JewDAECnhH0AAOiUsA8AAJ0S9gEAoFPCPgAAdErYBwCATgn7AADQKWEfAAA6JewDAECnhH0AAOjUTMJ+VZ1YVb9bVV+tqjurqlXVx7fT5vCquriqbq+qe6rqmqp6Q1U9eBttXlZVX6+qu6rqjqq6tKqO20b9varqrKq6vqrurarvVdUnquqQlVwvAADsDGY1sv/WJKckeWqS72yvclWdkOSyJEcm+WSSDyTZPcl7kmxcoM05Sc5Lsn+SDyf5eJJDk3y6qk6Zp/4eSb6Q5O1J7kzyviRfTPLCJFdW1bOWcH0AALDT2W1G/bwxybeTfDPJUUm+vFDFqtonQ1i/P8lzWmtXjtvfluSSJCdW1cmttY1TbQ5PcmqSm5I8s7X2g3H7u5NcleScqrqotbZ56lBvSnJEkk1JXtxae2Bsc0GSC5N8pKoOnWwHAIDezGRkv7X25dbaja21tojqJyZ5VJKNk6A/9nFvhr8QJMlr5rR59Vi+cxL0xzabM/xVYI8kL59sr6qaavOW6UDfWvtUkq8meXKGX0wAAKBLa/GA7tFj+bl59l2W5J4kh4/TcBbT5rNz6iTJgUken+SG1toti2wDAABdmdU0nqU4eCxvmLujtXZfVd2S5ClJnpDkuqraO8ljk9zVWrt1nv5uHMuDFnOMbbSZV1VdtcCuJ22vLQAArKW1GNnfdyzvWGD/ZPvDl1l/uW0AAKArazGyvz01louZ/z9tKfUXfYzW2mHzdjCM+D99CccEAIAdai1G9iej6vsusH+fOfW2V3++UfylHgMAALqzFmH/+rH8sfnyVbVbkgOS3Jfk5iRprd2dYe3+h1bV/vP098SxnJ6fv+AxttEGAAC6shZh/5KxPGaefUcmeUiSy1trWxfZ5nlz6iTDevzfSnJQVR2wyDYAANCVtQj7m5LcluTkqnrGZGNV7ZnkHeOPH5zT5kNjeXpVPWKqzYYkr02yNclHJ9vH9f4nbd5VVQ+aanNCkmcnuTbJV2ZwPQAAsC7N5AHdqnpBkheMPz5mLH+uqs4b//u21tqbk6S1dmdVvTJD6L+0qjYmuT3J8RmWzNyU5ILp/ltrl1fVuRneintNVW1KsnuSFyfZL8nr5rw9N0nOTXJchpd4XVFVX8qw9v5JGdbyf4W35wIA0LNZrcbz1CQvm7PtCeMnSf4qyZsnO1prF1bVUUlOT/KiJHsm+WaGMP/++d7E21o7taquSXJKklcleSDJ1Une3Vq7aJ76W6vquUlOS/KSJG9McmeSC5Oc0Vq7drkXCwAAO4OZhP3W2plJzlxim68lef4S25yf5Pwl1N+S5IzxAwAAu5S1mLMPAADsAMI+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU7ut9QkAAMBq2HDaZ2be5+azj515n6up+5H9qvrHVfWRqvqbqtpaVZur6r1V9Yi1PjcAAFhNXY/sV9WBSS5P8ugkn0ryl0l+Nsm/SXJMVR3RWvv+Gp4iAACsmt5H9v+fDEH/9a21F7TWTmutHZ3kPUkOTvLONT07AABYRd2G/ap6QpJfSrI5yQfm7D4jyd1JXlpVe+/gUwMAgB2i27Cf5Oix/Hxr7YHpHa21Hyb5WpKHJPlnO/rEAABgR+h5zv7BY3nDAvtvzDDyf1CSLy3USVVdtcCun7nuuuty2GGHLf8MV+DW79yxJscFANiVHfaFt+/wY1533XVJsmE5bXsO+/uO5UKpeLL94cvs//4tW7bccfXVV29eZvuVeNJY/uUaHJudm3uHlXD/sFzuHVZiXd0/V//tmhx2Q5I7l9Ow57C/PTWWbVuVWmtrM3S/DZO/NqzHc2N9c++wEu4flsu9w0q4f1am5zn7k5H7fRfYv8+cegAA0JWew/71Y3nQAvufOJYLzekHAICdWs9h/8tj+UtV9Q+us6oeluSIJFuS/NmOPjEAANgRug37rbWbknw+wwMNr52z+6wkeyf5w9ba3Tv41AAAYIfo/QHdf53k8iTvr6pfTHJdkmcl+YUM03dOX8NzAwCAVVWtbXMxmp1eVT0uyW8nOSbJI5PcmuTCJGe11m5fw1MDAIBV1X3YBwCAXVW3c/YBAGBXJ+wDAECnhH0AAOiUsA8AAJ0S9gEAoFPCPgAAdErYXweq6h9X1Ueq6m+qamtVba6q91bVI5bQx+aqagt8vrua58/amsX9M9XXs6vqj6rq1rGvW6vq81X1/NU4d9bWSu+dqvr1bXzvTD73r/Z1sDZm9d1TVceO3zPfrqotVXVzVf3Xqvq51Tp31taMck9V1Suq6s+q6odVdU9V/XlVvb6qHrya57+zsc7+GquqAzO85ffRST6V5C+T/GyGt/xen+SI1tr3F9HP5iQPT/LeeXbf1Vo7ZzZnzHoyq/tn7OutSf5dktuSXJThBXQ/meRpSb7cWnvLzC+ANTOLe6eqnprkBQvsfnaSo5N8prV23GzOmvVihv92/U6StyT5foYXXt6W5J8kOT7Jbkl+rbX28VW4BNbIDO+dP0zy0iTfS/LpJHcneW6SJyf5oyQnNSF30FrzWcNPkj9O0pK8bs72c8ftH1pkP5uTbF7r6/HZsZ8Z3j8njfW/kORh8+z/ibW+Vp/1ee9so/8/Hfs5fq2v1Wf2n1ncP0kek+T+JN9N8ug5+35h7Ofmtb5Wn3V577xgcn8k+cmp7T+R5JPjvl9f62tdLx8j+2uoqp6Q5KYMQf3A1toDU/selmFktTJ8Cd69nb42J0lrbcMqnS7rzKzun6p6UJJvJvlHSTa01v7nap43a2+W3z0L9P/TSf6/JN9J8lOtNVN5OjLD755nJfmzJP+ttXbCPPvvzDAD4WGzvQLWygzvncmo/imttQ/M2Tf5/rm6tXbYzC9iJ2TO/to6eiw/P33DJ0lr7YdJvpbkIUn+2SL726OqfrWqfquq/k1V/YJ5a12b1f1zeJIDklyc5Afj/NnfHO8hc2b7NOvvnrn+1Vj+gaDfpVndPzcm+V9JfraqfnJ6R1UdmeRhSb44kzNmvZjVvfOYsbx5nn2TbU+vqocv8zy7IuyvrYPH8oYF9t84lgctsr/HJPlYkndmmLt/SZIbq+qo5Z4g69qs7p9njuXfJrk6w3z9szPcQ5dX1Veq6lErOE/Wn1l/9/xIVe2V5FeTPJDkPy/91NgJzOT+aa3dnuQ3M/xV8dqq+k9V9R+q6hNJPp9hWuG/2lYf7HRm9d1z21geMM++J0z995MWeV5dE/bX1r5jeccC+yfbH76Ivj6a5BczBP69kxya5PeTbEjy2ar6mWWfJevVrO6fR4/lq5PsleEBp4cl+ekMcyuPTPJfl32WrEez/O6Z6/8c2322tfbXy2jP+jez+6e19t4kv5LhYdxXJjktwzNEf53kvNba91Zyoqw7s7p3LhrLN1XVfpONVbVbkrOm6i15VboeCfvrW43ldh+saK2d1Vq7pLX2t621e1pr32itvTrDAy97JTlzFc+T9Wmx989kqlclObG19qXW2l2ttb9I8sIk305ylCk9u5RFf/fM41Vj+fszOhd2Pou+f6rqLUk2JTkvyYEZBqsOyzAV479U1btW6RxZnxZ772xM8tkM98zkr0LvTfLfkzw///svBKYRRthfa5PfYPddYP8+c+otx4fG8sgV9MH6NKv75wdjeXNr7X9M72itbckwup8MS6PRh1X57qmqJ2d4BuTbGZ4BoU8zuX+q6jlJfifDA7pvaq3dPA5WXZ1hoOE7SU4dH+qkDzO5d8b5/scneXOG1ZxemuQVGb57fj7DUq7JsCznLk/YX1vXj+VCc9OeOJYLzW1bjMmNvvcK+mB9mtX9M+nn7xbYP/llYK/FnRY7gdX67vFg7q5hVvfP5P0LX567o7V2T5KvZ8gpT1vqCbJuzey7p7V2X2vtP7bWntpa26u1tk9r7Zgk1yZ5apItSf5ipSfcA2F/bU2+4H5pXP7wR8YlqI7IcLP+2QqOMZl6Md8T6+zcZnX/XJbkviRPrKrd59n/02O5efmnyjoz8++eqtozw+jaA0n+YEbnyfo0q/tnj7FcaAGAyfb/tZyTZF3aEbnnpUn2TPKJ1trfr6Cfbgj7a6i1dlOGFQc2JHntnN1nZRiN/8PJWrNV9RNV9aTx7XM/UlVPmX5AZWr7TyX5vfFHbyDszKzun9babUkuyPBn1bdP76uqf57kX2T4k+rnVuEyWAOzunfmOCnDw3AXezC3bzO8f746lq+qqsdO76iq52UIfvdmeNsqHZjld09V7TPPtmdmWE3uriS/Pduz33l5qdYam+e10dcleVaGtwfekOTwNr42uqo2JLklyV9Nvzyrqs7MsILBl8f9P8zw0MqxGX67vTjJC1trRkc6M4v7Z9z36AzrG/+TDP8Afz3JT2WYN9uSvKS1ZkWejszq3pnq76sZ5soe31r79GqfP2trRv92PSjDM0HPzfDv1iczzL8+JMMUn0ryhtba+3bIRbFDzPDfrSsy/BXgGxnun6dkeDh3a5Jfaa39cUgi7K8LVfW4DL+BHpPkkRneIHdhkrPGdYgn9TZk/i/MozIsm/i0/O+lN/8uw1PpH0vyseZ/dLdWev9M7d8vyVszBPzHZvjy/JMk/6G1tpI/qbJOzfDeOSTDPNlvZ3gLs/n6u4BZ3D9V9RMZRnhPTvLkDC9Uuj3DgMP7W2ufX+3rYMeb0b3zbzPcNwdmeKbsbzL88nh2a23zal/DzkTYBwCATpmzDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnRL2AQCgU8I+AAB0StgHAIBOCfsAANApYR8AADol7AMAQKeEfQAA6JSwDwAAnfr/AZLArXosgnvXAAAAAElFTkSuQmCC\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "image/png": {
       "height": 248,
       "width": 381
      },
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "l2g_scores = [y for x in bestgenes_df.bestLocus2Genes_score for y in x]\n",
    "plt.hist(l2g_scores, bins=30);"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 74,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.9243353605270386"
      ]
     },
     "execution_count": 74,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "np.nanmax(l2g_scores)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 75,
   "metadata": {},
   "outputs": [],
   "source": [
    "l2g_max_scores = [np.nanmax(x) if x else np.nan for x in bestgenes_df.bestLocus2Genes_score]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 76,
   "metadata": {},
   "outputs": [],
   "source": [
    "max_study_idx = np.nanargmax(l2g_max_scores)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 77,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>study</th>\n",
       "      <th>bestGenes_id</th>\n",
       "      <th>bestGenes_symbol</th>\n",
       "      <th>bestColocGenes_id</th>\n",
       "      <th>bestColocGenes_symbol</th>\n",
       "      <th>bestLocus2Genes_id</th>\n",
       "      <th>bestLocus2Genes_symbol</th>\n",
       "      <th>bestLocus2Genes_score</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>pvalMantissa</th>\n",
       "      <th>pvalExponent</th>\n",
       "      <th>credibleSetSize</th>\n",
       "      <th>ldSetSize</th>\n",
       "      <th>totalSetSize</th>\n",
       "      <th>pval</th>\n",
       "      <th>oddsRatio</th>\n",
       "      <th>oddsRatioCILower</th>\n",
       "      <th>oddsRatioCIUpper</th>\n",
       "      <th>beta</th>\n",
       "      <th>betaCILower</th>\n",
       "      <th>betaCIUpper</th>\n",
       "      <th>direction</th>\n",
       "      <th>variant_chromosome</th>\n",
       "      <th>variant_position</th>\n",
       "      <th>variant_refAllele</th>\n",
       "      <th>variant_altAllele</th>\n",
       "      <th>variant_rsId</th>\n",
       "      <th>variant_chromosomeB37</th>\n",
       "      <th>variant_positionB37</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_nearestGene</th>\n",
       "      <th>variant_nearestGeneDistance</th>\n",
       "      <th>variant_nearestCodingGene</th>\n",
       "      <th>variant_nearestCodingGeneDistance</th>\n",
       "      <th>variant_mostSevereConsequence</th>\n",
       "      <th>variant_caddRaw</th>\n",
       "      <th>variant_caddPhred</th>\n",
       "      <th>variant_gnomadAFR</th>\n",
       "      <th>variant_gnomadAMR</th>\n",
       "      <th>variant_gnomadASJ</th>\n",
       "      <th>variant_gnomadEAS</th>\n",
       "      <th>variant_gnomadFIN</th>\n",
       "      <th>variant_gnomadNFE</th>\n",
       "      <th>variant_gnomadNFEEST</th>\n",
       "      <th>variant_gnomadNFENWE</th>\n",
       "      <th>variant_gnomadNFESEU</th>\n",
       "      <th>variant_gnomadNFEONF</th>\n",
       "      <th>variant_gnomadOTH</th>\n",
       "      <th>variant_nearestGene_id</th>\n",
       "      <th>variant_nearestGene_symbol</th>\n",
       "      <th>variant_nearestGene_bioType</th>\n",
       "      <th>variant_nearestGene_description</th>\n",
       "      <th>variant_nearestGene_chromosome</th>\n",
       "      <th>variant_nearestGene_tss</th>\n",
       "      <th>variant_nearestGene_start</th>\n",
       "      <th>variant_nearestGene_end</th>\n",
       "      <th>variant_nearestGene_fwdStrand</th>\n",
       "      <th>variant_nearestGene_exons</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>variant_nearestCodingGene_bioType</th>\n",
       "      <th>variant_nearestCodingGene_description</th>\n",
       "      <th>variant_nearestCodingGene_chromosome</th>\n",
       "      <th>variant_nearestCodingGene_tss</th>\n",
       "      <th>variant_nearestCodingGene_start</th>\n",
       "      <th>variant_nearestCodingGene_end</th>\n",
       "      <th>variant_nearestCodingGene_fwdStrand</th>\n",
       "      <th>variant_nearestCodingGene_exons</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>190695</th>\n",
       "      <td>NEALE2_23119_raw</td>\n",
       "      <td>(ENSG00000038427,)</td>\n",
       "      <td>(VCAN,)</td>\n",
       "      <td>(ENSG00000038427,)</td>\n",
       "      <td>(VCAN,)</td>\n",
       "      <td>(ENSG00000038427,)</td>\n",
       "      <td>(VCAN,)</td>\n",
       "      <td>(0.9243353605270386,)</td>\n",
       "      <td>(ENSG00000038427,)</td>\n",
       "      <td>(VCAN,)</td>\n",
       "      <td>2.5618</td>\n",
       "      <td>-9</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>2.561800e-09</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-0.265494</td>\n",
       "      <td>-0.352839</td>\n",
       "      <td>-0.178149</td>\n",
       "      <td>-</td>\n",
       "      <td>5</td>\n",
       "      <td>83515065</td>\n",
       "      <td>T</td>\n",
       "      <td>C</td>\n",
       "      <td>rs34580448</td>\n",
       "      <td>5</td>\n",
       "      <td>82810884</td>\n",
       "      <td>5_83515065_T_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>43447</td>\n",
       "      <td>NaN</td>\n",
       "      <td>43447</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>-0.208701</td>\n",
       "      <td>0.675</td>\n",
       "      <td>0.006884</td>\n",
       "      <td>0.030733</td>\n",
       "      <td>0.055172</td>\n",
       "      <td>0</td>\n",
       "      <td>0.017271</td>\n",
       "      <td>0.036038</td>\n",
       "      <td>0.027233</td>\n",
       "      <td>0.039437</td>\n",
       "      <td>0.009434</td>\n",
       "      <td>0.042603</td>\n",
       "      <td>0.027574</td>\n",
       "      <td>ENSG00000038427</td>\n",
       "      <td>VCAN</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>versican [Source:HGNC Symbol;Acc:HGNC:2464]</td>\n",
       "      <td>5</td>\n",
       "      <td>83471618.0</td>\n",
       "      <td>83471618.0</td>\n",
       "      <td>83582303.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[83471744, 83472023, 83490098, 83490472, 83483...</td>\n",
       "      <td>ENSG00000038427</td>\n",
       "      <td>VCAN</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>versican [Source:HGNC Symbol;Acc:HGNC:2464]</td>\n",
       "      <td>5</td>\n",
       "      <td>83471618.0</td>\n",
       "      <td>83471618.0</td>\n",
       "      <td>83582303.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[83471744, 83472023, 83490098, 83490472, 83483...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                   study        bestGenes_id bestGenes_symbol  \\\n",
       "190695  NEALE2_23119_raw  (ENSG00000038427,)          (VCAN,)   \n",
       "\n",
       "         bestColocGenes_id bestColocGenes_symbol  bestLocus2Genes_id  \\\n",
       "190695  (ENSG00000038427,)               (VCAN,)  (ENSG00000038427,)   \n",
       "\n",
       "       bestLocus2Genes_symbol  bestLocus2Genes_score  \\\n",
       "190695                (VCAN,)  (0.9243353605270386,)   \n",
       "\n",
       "       bestLocus2GenesOrClosest_id bestLocus2GenesOrClosest_symbol  \\\n",
       "190695          (ENSG00000038427,)                         (VCAN,)   \n",
       "\n",
       "        pvalMantissa  pvalExponent  credibleSetSize  ldSetSize  totalSetSize  \\\n",
       "190695        2.5618            -9                4          4             4   \n",
       "\n",
       "                pval oddsRatio oddsRatioCILower oddsRatioCIUpper      beta  \\\n",
       "190695  2.561800e-09      None             None             None -0.265494   \n",
       "\n",
       "       betaCILower betaCIUpper direction variant_chromosome  variant_position  \\\n",
       "190695   -0.352839   -0.178149         -                  5          83515065   \n",
       "\n",
       "       variant_refAllele variant_altAllele variant_rsId variant_chromosomeB37  \\\n",
       "190695                 T                 C   rs34580448                     5   \n",
       "\n",
       "       variant_positionB37      variant_id variant_nearestGene  \\\n",
       "190695            82810884  5_83515065_T_C                 NaN   \n",
       "\n",
       "       variant_nearestGeneDistance variant_nearestCodingGene  \\\n",
       "190695                       43447                       NaN   \n",
       "\n",
       "       variant_nearestCodingGeneDistance variant_mostSevereConsequence  \\\n",
       "190695                             43447                intron_variant   \n",
       "\n",
       "       variant_caddRaw variant_caddPhred variant_gnomadAFR variant_gnomadAMR  \\\n",
       "190695       -0.208701             0.675          0.006884          0.030733   \n",
       "\n",
       "       variant_gnomadASJ variant_gnomadEAS variant_gnomadFIN  \\\n",
       "190695          0.055172                 0          0.017271   \n",
       "\n",
       "       variant_gnomadNFE variant_gnomadNFEEST variant_gnomadNFENWE  \\\n",
       "190695          0.036038             0.027233             0.039437   \n",
       "\n",
       "       variant_gnomadNFESEU variant_gnomadNFEONF variant_gnomadOTH  \\\n",
       "190695             0.009434             0.042603          0.027574   \n",
       "\n",
       "       variant_nearestGene_id variant_nearestGene_symbol  \\\n",
       "190695        ENSG00000038427                       VCAN   \n",
       "\n",
       "       variant_nearestGene_bioType  \\\n",
       "190695              protein_coding   \n",
       "\n",
       "                    variant_nearestGene_description  \\\n",
       "190695  versican [Source:HGNC Symbol;Acc:HGNC:2464]   \n",
       "\n",
       "       variant_nearestGene_chromosome  variant_nearestGene_tss  \\\n",
       "190695                              5               83471618.0   \n",
       "\n",
       "        variant_nearestGene_start  variant_nearestGene_end  \\\n",
       "190695                 83471618.0               83582303.0   \n",
       "\n",
       "       variant_nearestGene_fwdStrand  \\\n",
       "190695                          True   \n",
       "\n",
       "                                variant_nearestGene_exons  \\\n",
       "190695  [83471744, 83472023, 83490098, 83490472, 83483...   \n",
       "\n",
       "       variant_nearestCodingGene_id variant_nearestCodingGene_symbol  \\\n",
       "190695              ENSG00000038427                             VCAN   \n",
       "\n",
       "       variant_nearestCodingGene_bioType  \\\n",
       "190695                    protein_coding   \n",
       "\n",
       "              variant_nearestCodingGene_description  \\\n",
       "190695  versican [Source:HGNC Symbol;Acc:HGNC:2464]   \n",
       "\n",
       "       variant_nearestCodingGene_chromosome  variant_nearestCodingGene_tss  \\\n",
       "190695                                    5                     83471618.0   \n",
       "\n",
       "        variant_nearestCodingGene_start  variant_nearestCodingGene_end  \\\n",
       "190695                       83471618.0                     83582303.0   \n",
       "\n",
       "       variant_nearestCodingGene_fwdStrand  \\\n",
       "190695                                True   \n",
       "\n",
       "                          variant_nearestCodingGene_exons  \n",
       "190695  [83471744, 83472023, 83490098, 83490472, 83483...  "
      ]
     },
     "execution_count": 77,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.iloc[[max_study_idx]]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 78,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>study</th>\n",
       "      <th>bestGenes_id</th>\n",
       "      <th>bestGenes_symbol</th>\n",
       "      <th>bestColocGenes_id</th>\n",
       "      <th>bestColocGenes_symbol</th>\n",
       "      <th>bestLocus2Genes_id</th>\n",
       "      <th>bestLocus2Genes_symbol</th>\n",
       "      <th>bestLocus2Genes_score</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>pvalMantissa</th>\n",
       "      <th>pvalExponent</th>\n",
       "      <th>credibleSetSize</th>\n",
       "      <th>ldSetSize</th>\n",
       "      <th>totalSetSize</th>\n",
       "      <th>pval</th>\n",
       "      <th>oddsRatio</th>\n",
       "      <th>oddsRatioCILower</th>\n",
       "      <th>oddsRatioCIUpper</th>\n",
       "      <th>beta</th>\n",
       "      <th>betaCILower</th>\n",
       "      <th>betaCIUpper</th>\n",
       "      <th>direction</th>\n",
       "      <th>variant_chromosome</th>\n",
       "      <th>variant_position</th>\n",
       "      <th>variant_refAllele</th>\n",
       "      <th>variant_altAllele</th>\n",
       "      <th>variant_rsId</th>\n",
       "      <th>variant_chromosomeB37</th>\n",
       "      <th>variant_positionB37</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_nearestGene</th>\n",
       "      <th>variant_nearestGeneDistance</th>\n",
       "      <th>variant_nearestCodingGene</th>\n",
       "      <th>variant_nearestCodingGeneDistance</th>\n",
       "      <th>variant_mostSevereConsequence</th>\n",
       "      <th>variant_caddRaw</th>\n",
       "      <th>variant_caddPhred</th>\n",
       "      <th>variant_gnomadAFR</th>\n",
       "      <th>variant_gnomadAMR</th>\n",
       "      <th>variant_gnomadASJ</th>\n",
       "      <th>variant_gnomadEAS</th>\n",
       "      <th>variant_gnomadFIN</th>\n",
       "      <th>variant_gnomadNFE</th>\n",
       "      <th>variant_gnomadNFEEST</th>\n",
       "      <th>variant_gnomadNFENWE</th>\n",
       "      <th>variant_gnomadNFESEU</th>\n",
       "      <th>variant_gnomadNFEONF</th>\n",
       "      <th>variant_gnomadOTH</th>\n",
       "      <th>variant_nearestGene_id</th>\n",
       "      <th>variant_nearestGene_symbol</th>\n",
       "      <th>variant_nearestGene_bioType</th>\n",
       "      <th>variant_nearestGene_description</th>\n",
       "      <th>variant_nearestGene_chromosome</th>\n",
       "      <th>variant_nearestGene_tss</th>\n",
       "      <th>variant_nearestGene_start</th>\n",
       "      <th>variant_nearestGene_end</th>\n",
       "      <th>variant_nearestGene_fwdStrand</th>\n",
       "      <th>variant_nearestGene_exons</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>variant_nearestCodingGene_bioType</th>\n",
       "      <th>variant_nearestCodingGene_description</th>\n",
       "      <th>variant_nearestCodingGene_chromosome</th>\n",
       "      <th>variant_nearestCodingGene_tss</th>\n",
       "      <th>variant_nearestCodingGene_start</th>\n",
       "      <th>variant_nearestCodingGene_end</th>\n",
       "      <th>variant_nearestCodingGene_fwdStrand</th>\n",
       "      <th>variant_nearestCodingGene_exons</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>FINNGEN_R5_AB1_GHLAMY_OTHER</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(0.6906188130378723, 0.5723833441734314)</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>2.015</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>2.015000e-08</td>\n",
       "      <td>7938577976.443386</td>\n",
       "      <td>2763395.679138</td>\n",
       "      <td>22805644795582.570312</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>FINNGEN_R5_AB1_MEASLES</td>\n",
       "      <td>(ENSG00000273396, ENSG00000163132)</td>\n",
       "      <td>(LINC01396, MSX1)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "      <td>(0.6779915690422058,)</td>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "      <td>4.990</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>13</td>\n",
       "      <td>13</td>\n",
       "      <td>4.990000e-08</td>\n",
       "      <td>0.552501</td>\n",
       "      <td>0.446371</td>\n",
       "      <td>0.683865</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>4</td>\n",
       "      <td>4864861</td>\n",
       "      <td>A</td>\n",
       "      <td>C</td>\n",
       "      <td>rs6825765</td>\n",
       "      <td>4</td>\n",
       "      <td>4866588</td>\n",
       "      <td>4_4864861_A_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>NaN</td>\n",
       "      <td>5196</td>\n",
       "      <td>downstream_gene_variant</td>\n",
       "      <td>0.129132</td>\n",
       "      <td>4.745</td>\n",
       "      <td>0.468369</td>\n",
       "      <td>0.612028</td>\n",
       "      <td>0.375862</td>\n",
       "      <td>0.652706</td>\n",
       "      <td>0.601729</td>\n",
       "      <td>0.464031</td>\n",
       "      <td>0.508534</td>\n",
       "      <td>0.448545</td>\n",
       "      <td>0.443396</td>\n",
       "      <td>0.432116</td>\n",
       "      <td>0.48893</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "      <td>ENSG00000163132</td>\n",
       "      <td>MSX1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]</td>\n",
       "      <td>4</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4859665.0</td>\n",
       "      <td>4863936.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[4862701, 4863936, 4859665, 4860368]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>(0.6587790846824646,)</td>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>6.133</td>\n",
       "      <td>-10</td>\n",
       "      <td>3</td>\n",
       "      <td>4</td>\n",
       "      <td>4</td>\n",
       "      <td>6.133000e-10</td>\n",
       "      <td>0.874765</td>\n",
       "      <td>0.838461</td>\n",
       "      <td>0.912641</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>-</td>\n",
       "      <td>1</td>\n",
       "      <td>159743672</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs74596724</td>\n",
       "      <td>1</td>\n",
       "      <td>159713462</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>NaN</td>\n",
       "      <td>29083</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.770176</td>\n",
       "      <td>11.64</td>\n",
       "      <td>0.011703</td>\n",
       "      <td>0.040094</td>\n",
       "      <td>0.096552</td>\n",
       "      <td>0.164103</td>\n",
       "      <td>0.063364</td>\n",
       "      <td>0.075765</td>\n",
       "      <td>0.096288</td>\n",
       "      <td>0.067939</td>\n",
       "      <td>0.09434</td>\n",
       "      <td>0.062324</td>\n",
       "      <td>0.0625</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "      <td>ENSG00000132693</td>\n",
       "      <td>CRP</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>C-reactive protein [Source:HGNC Symbol;Acc:HGN...</td>\n",
       "      <td>1</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>159712289.0</td>\n",
       "      <td>159714589.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[159714425, 159714589, 159712289, 159714138]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_BACTERIAL</td>\n",
       "      <td>(ENSG00000235532,)</td>\n",
       "      <td>(LINC00402,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000118922,)</td>\n",
       "      <td>(KLF12,)</td>\n",
       "      <td>(0.8585225939750671,)</td>\n",
       "      <td>(ENSG00000118922,)</td>\n",
       "      <td>(KLF12,)</td>\n",
       "      <td>4.023</td>\n",
       "      <td>-8</td>\n",
       "      <td>8</td>\n",
       "      <td>0</td>\n",
       "      <td>8</td>\n",
       "      <td>4.023000e-08</td>\n",
       "      <td>1.997507</td>\n",
       "      <td>1.560296</td>\n",
       "      <td>2.55723</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>13</td>\n",
       "      <td>74291635</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs117832616</td>\n",
       "      <td>13</td>\n",
       "      <td>74865772</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>60178</td>\n",
       "      <td>NaN</td>\n",
       "      <td>296579</td>\n",
       "      <td>upstream_gene_variant</td>\n",
       "      <td>-0.24534</td>\n",
       "      <td>0.528</td>\n",
       "      <td>0</td>\n",
       "      <td>0.002358</td>\n",
       "      <td>0</td>\n",
       "      <td>0.010296</td>\n",
       "      <td>0.003165</td>\n",
       "      <td>0.000519</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000935</td>\n",
       "      <td>0</td>\n",
       "      <td>ENSG00000235532</td>\n",
       "      <td>LINC00402</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>long intergenic non-protein coding RNA 402 [So...</td>\n",
       "      <td>13</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74231457.0</td>\n",
       "      <td>74259976.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[74256933, 74259976, 74231457, 74231752]</td>\n",
       "      <td>ENSG00000118922</td>\n",
       "      <td>KLF12</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Kruppel like factor 12 [Source:HGNC Symbol;Acc...</td>\n",
       "      <td>13</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>73686089.0</td>\n",
       "      <td>73995056.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[73686089, 73695671, 73715368, 73715525, 73764...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>FINNGEN_R5_AB1_OTHER_CHLAMYDIAE</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(0.6522198915481567, 0.568143904209137)</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>1.552</td>\n",
       "      <td>-9</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>1.552000e-09</td>\n",
       "      <td>20134487948.29578</td>\n",
       "      <td>9112823.906844</td>\n",
       "      <td>44486496072376.03125</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>6</td>\n",
       "      <td>46877116</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>224101</th>\n",
       "      <td>SAIGE_960_2</td>\n",
       "      <td>(ENSG00000251075,)</td>\n",
       "      <td>(HTT-AS,)</td>\n",
       "      <td>(ENSG00000159788,)</td>\n",
       "      <td>(RGS12,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "      <td>2.950</td>\n",
       "      <td>-9</td>\n",
       "      <td>18</td>\n",
       "      <td>9</td>\n",
       "      <td>26</td>\n",
       "      <td>2.950000e-09</td>\n",
       "      <td>1.141108</td>\n",
       "      <td>1.09252</td>\n",
       "      <td>1.191857</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>4</td>\n",
       "      <td>3240118</td>\n",
       "      <td>C</td>\n",
       "      <td>T</td>\n",
       "      <td>rs362307</td>\n",
       "      <td>4</td>\n",
       "      <td>3241845</td>\n",
       "      <td>4_3240118_C_T</td>\n",
       "      <td>NaN</td>\n",
       "      <td>4251</td>\n",
       "      <td>NaN</td>\n",
       "      <td>4251</td>\n",
       "      <td>3_prime_UTR_variant</td>\n",
       "      <td>-0.124826</td>\n",
       "      <td>1.185</td>\n",
       "      <td>0.014696</td>\n",
       "      <td>0.117925</td>\n",
       "      <td>0.027586</td>\n",
       "      <td>0.001282</td>\n",
       "      <td>0.065055</td>\n",
       "      <td>0.081204</td>\n",
       "      <td>0.091266</td>\n",
       "      <td>0.079572</td>\n",
       "      <td>0.084906</td>\n",
       "      <td>0.066011</td>\n",
       "      <td>0.069853</td>\n",
       "      <td>ENSG00000188981</td>\n",
       "      <td>MSANTD1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Myb/SANT DNA binding domain containing 1 [Sour...</td>\n",
       "      <td>4</td>\n",
       "      <td>3244369.0</td>\n",
       "      <td>3244369.0</td>\n",
       "      <td>3271738.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[3255725, 3256613, 3253207, 3253482, 3249159, ...</td>\n",
       "      <td>ENSG00000188981</td>\n",
       "      <td>MSANTD1</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>Myb/SANT DNA binding domain containing 1 [Sour...</td>\n",
       "      <td>4</td>\n",
       "      <td>3244369.0</td>\n",
       "      <td>3244369.0</td>\n",
       "      <td>3271738.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[3255725, 3256613, 3253207, 3253482, 3249159, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>224102</th>\n",
       "      <td>SAIGE_965</td>\n",
       "      <td>(ENSG00000254239, ENSG00000253927, ENSG0000014...</td>\n",
       "      <td>(AC002428.2, AC002428.1, IL9)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "      <td>3.990</td>\n",
       "      <td>-8</td>\n",
       "      <td>4</td>\n",
       "      <td>0</td>\n",
       "      <td>4</td>\n",
       "      <td>3.990000e-08</td>\n",
       "      <td>2.083398</td>\n",
       "      <td>1.602164</td>\n",
       "      <td>2.709177</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>5</td>\n",
       "      <td>135834716</td>\n",
       "      <td>T</td>\n",
       "      <td>G</td>\n",
       "      <td>rs141243065</td>\n",
       "      <td>5</td>\n",
       "      <td>135170405</td>\n",
       "      <td>5_135834716_T_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>61111</td>\n",
       "      <td>NaN</td>\n",
       "      <td>61111</td>\n",
       "      <td>5_prime_UTR_variant</td>\n",
       "      <td>0.91253</td>\n",
       "      <td>12.69</td>\n",
       "      <td>0.000919</td>\n",
       "      <td>0.001179</td>\n",
       "      <td>0.006897</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.000288</td>\n",
       "      <td>0.004088</td>\n",
       "      <td>0.001532</td>\n",
       "      <td>0.005119</td>\n",
       "      <td>0.009434</td>\n",
       "      <td>0.005145</td>\n",
       "      <td>0.004604</td>\n",
       "      <td>ENSG00000145839</td>\n",
       "      <td>IL9</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>interleukin 9 [Source:HGNC Symbol;Acc:HGNC:6029]</td>\n",
       "      <td>5</td>\n",
       "      <td>135895827.0</td>\n",
       "      <td>135892246.0</td>\n",
       "      <td>135895827.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[135895440, 135895472, 135895555, 135895590, 1...</td>\n",
       "      <td>ENSG00000145839</td>\n",
       "      <td>IL9</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>interleukin 9 [Source:HGNC Symbol;Acc:HGNC:6029]</td>\n",
       "      <td>5</td>\n",
       "      <td>135895827.0</td>\n",
       "      <td>135892246.0</td>\n",
       "      <td>135895827.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[135895440, 135895472, 135895555, 135895590, 1...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>224103</th>\n",
       "      <td>SAIGE_965_1</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>(0.8918408751487732,)</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>1.810</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>1.810000e-08</td>\n",
       "      <td>2.539583</td>\n",
       "      <td>1.834247</td>\n",
       "      <td>3.516148</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>5</td>\n",
       "      <td>111211885</td>\n",
       "      <td>A</td>\n",
       "      <td>G</td>\n",
       "      <td>rs72793560</td>\n",
       "      <td>5</td>\n",
       "      <td>110547583</td>\n",
       "      <td>5_111211885_A_G</td>\n",
       "      <td>NaN</td>\n",
       "      <td>11768</td>\n",
       "      <td>NaN</td>\n",
       "      <td>11768</td>\n",
       "      <td>intergenic_variant</td>\n",
       "      <td>0.071646</td>\n",
       "      <td>3.792</td>\n",
       "      <td>0.003381</td>\n",
       "      <td>0.01706</td>\n",
       "      <td>0.024476</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.018482</td>\n",
       "      <td>0.02138</td>\n",
       "      <td>0.018255</td>\n",
       "      <td>0.023478</td>\n",
       "      <td>0.018868</td>\n",
       "      <td>0.019712</td>\n",
       "      <td>0.022857</td>\n",
       "      <td>ENSG00000152495</td>\n",
       "      <td>CAMK4</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>calcium/calmodulin dependent protein kinase IV...</td>\n",
       "      <td>5</td>\n",
       "      <td>111223653.0</td>\n",
       "      <td>111223653.0</td>\n",
       "      <td>111494886.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[111484026, 111494886, 111394710, 111394782, 1...</td>\n",
       "      <td>ENSG00000152495</td>\n",
       "      <td>CAMK4</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>calcium/calmodulin dependent protein kinase IV...</td>\n",
       "      <td>5</td>\n",
       "      <td>111223653.0</td>\n",
       "      <td>111223653.0</td>\n",
       "      <td>111494886.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[111484026, 111494886, 111394710, 111394782, 1...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>224104</th>\n",
       "      <td>SAIGE_967</td>\n",
       "      <td>(ENSG00000266450,)</td>\n",
       "      <td>(AC019183.1,)</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>()</td>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "      <td>3.340</td>\n",
       "      <td>-8</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>3.340000e-08</td>\n",
       "      <td>1.388189</td>\n",
       "      <td>1.235621</td>\n",
       "      <td>1.559595</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>18</td>\n",
       "      <td>1777012</td>\n",
       "      <td>G</td>\n",
       "      <td>A</td>\n",
       "      <td>rs4600536</td>\n",
       "      <td>18</td>\n",
       "      <td>1777013</td>\n",
       "      <td>18_1777012_G_A</td>\n",
       "      <td>NaN</td>\n",
       "      <td>3317</td>\n",
       "      <td>NaN</td>\n",
       "      <td>794497</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>-0.054059</td>\n",
       "      <td>1.888</td>\n",
       "      <td>0.657676</td>\n",
       "      <td>0.453682</td>\n",
       "      <td>0.458621</td>\n",
       "      <td>0.47365</td>\n",
       "      <td>0.495109</td>\n",
       "      <td>0.478046</td>\n",
       "      <td>0.507909</td>\n",
       "      <td>0.461556</td>\n",
       "      <td>0.481132</td>\n",
       "      <td>0.480319</td>\n",
       "      <td>0.534323</td>\n",
       "      <td>ENSG00000264080</td>\n",
       "      <td>AP005057.1</td>\n",
       "      <td>lincRNA</td>\n",
       "      <td>novel transcript</td>\n",
       "      <td>18</td>\n",
       "      <td>1780329.0</td>\n",
       "      <td>1780329.0</td>\n",
       "      <td>1782064.0</td>\n",
       "      <td>True</td>\n",
       "      <td>[1781714, 1782064, 1780578, 1780639, 1780329, ...</td>\n",
       "      <td>ENSG00000101574</td>\n",
       "      <td>METTL4</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>methyltransferase like 4 [Source:HGNC Symbol;A...</td>\n",
       "      <td>18</td>\n",
       "      <td>2571509.0</td>\n",
       "      <td>2537525.0</td>\n",
       "      <td>2571509.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[2537530, 2539145, 2544195, 2544286, 2544653, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>224105</th>\n",
       "      <td>SAIGE_971</td>\n",
       "      <td>(ENSG00000167306,)</td>\n",
       "      <td>(MYO5B,)</td>\n",
       "      <td>(ENSG00000154832,)</td>\n",
       "      <td>(CXXC1,)</td>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "      <td>(0.8350275158882141,)</td>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "      <td>4.110</td>\n",
       "      <td>-8</td>\n",
       "      <td>14</td>\n",
       "      <td>13</td>\n",
       "      <td>17</td>\n",
       "      <td>4.110000e-08</td>\n",
       "      <td>1.780688</td>\n",
       "      <td>1.449467</td>\n",
       "      <td>2.187597</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>+</td>\n",
       "      <td>18</td>\n",
       "      <td>50238751</td>\n",
       "      <td>G</td>\n",
       "      <td>C</td>\n",
       "      <td>rs35839946</td>\n",
       "      <td>18</td>\n",
       "      <td>47765121</td>\n",
       "      <td>18_50238751_G_C</td>\n",
       "      <td>NaN</td>\n",
       "      <td>17710</td>\n",
       "      <td>NaN</td>\n",
       "      <td>27744</td>\n",
       "      <td>intron_variant</td>\n",
       "      <td>0.606433</td>\n",
       "      <td>10.33</td>\n",
       "      <td>0.140313</td>\n",
       "      <td>0.206856</td>\n",
       "      <td>0.416667</td>\n",
       "      <td>0.060256</td>\n",
       "      <td>0.406936</td>\n",
       "      <td>0.396039</td>\n",
       "      <td>0.375599</td>\n",
       "      <td>0.404106</td>\n",
       "      <td>0.396226</td>\n",
       "      <td>0.407598</td>\n",
       "      <td>0.360185</td>\n",
       "      <td>ENSG00000277310</td>\n",
       "      <td>AC090246.1</td>\n",
       "      <td>sense_intronic</td>\n",
       "      <td>novel transcript, sense intronic to CCDC11</td>\n",
       "      <td>18</td>\n",
       "      <td>50256461.0</td>\n",
       "      <td>50256036.0</td>\n",
       "      <td>50256461.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[50256036, 50256461]</td>\n",
       "      <td>ENSG00000172361</td>\n",
       "      <td>CFAP53</td>\n",
       "      <td>protein_coding</td>\n",
       "      <td>cilia and flagella associated protein 53 [Sour...</td>\n",
       "      <td>18</td>\n",
       "      <td>50266495.0</td>\n",
       "      <td>50227193.0</td>\n",
       "      <td>50266495.0</td>\n",
       "      <td>False</td>\n",
       "      <td>[50227193, 50227609, 50238603, 50238705, 50242...</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>224106 rows × 69 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                  study  \\\n",
       "0           FINNGEN_R5_AB1_GHLAMY_OTHER   \n",
       "1                FINNGEN_R5_AB1_MEASLES   \n",
       "2        FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "3        FINNGEN_R5_AB1_OTHER_BACTERIAL   \n",
       "4       FINNGEN_R5_AB1_OTHER_CHLAMYDIAE   \n",
       "...                                 ...   \n",
       "224101                      SAIGE_960_2   \n",
       "224102                        SAIGE_965   \n",
       "224103                      SAIGE_965_1   \n",
       "224104                        SAIGE_967   \n",
       "224105                        SAIGE_971   \n",
       "\n",
       "                                             bestGenes_id  \\\n",
       "0                                                      ()   \n",
       "1                      (ENSG00000273396, ENSG00000163132)   \n",
       "2                                      (ENSG00000132693,)   \n",
       "3                                      (ENSG00000235532,)   \n",
       "4                                                      ()   \n",
       "...                                                   ...   \n",
       "224101                                 (ENSG00000251075,)   \n",
       "224102  (ENSG00000254239, ENSG00000253927, ENSG0000014...   \n",
       "224103                                 (ENSG00000152495,)   \n",
       "224104                                 (ENSG00000266450,)   \n",
       "224105                                 (ENSG00000167306,)   \n",
       "\n",
       "                     bestGenes_symbol   bestColocGenes_id  \\\n",
       "0                                  ()                  ()   \n",
       "1                   (LINC01396, MSX1)                  ()   \n",
       "2                              (CRP,)                  ()   \n",
       "3                        (LINC00402,)                  ()   \n",
       "4                                  ()                  ()   \n",
       "...                               ...                 ...   \n",
       "224101                      (HTT-AS,)  (ENSG00000159788,)   \n",
       "224102  (AC002428.2, AC002428.1, IL9)                  ()   \n",
       "224103                       (CAMK4,)                  ()   \n",
       "224104                  (AC019183.1,)                  ()   \n",
       "224105                       (MYO5B,)  (ENSG00000154832,)   \n",
       "\n",
       "       bestColocGenes_symbol                  bestLocus2Genes_id  \\\n",
       "0                         ()  (ENSG00000112818, ENSG00000069122)   \n",
       "1                         ()                  (ENSG00000163132,)   \n",
       "2                         ()                  (ENSG00000132693,)   \n",
       "3                         ()                  (ENSG00000118922,)   \n",
       "4                         ()  (ENSG00000112818, ENSG00000069122)   \n",
       "...                      ...                                 ...   \n",
       "224101              (RGS12,)                                  ()   \n",
       "224102                    ()                                  ()   \n",
       "224103                    ()                  (ENSG00000152495,)   \n",
       "224104                    ()                                  ()   \n",
       "224105              (CXXC1,)                  (ENSG00000172361,)   \n",
       "\n",
       "       bestLocus2Genes_symbol                     bestLocus2Genes_score  \\\n",
       "0             (MEP1A, ADGRF5)  (0.6906188130378723, 0.5723833441734314)   \n",
       "1                     (MSX1,)                     (0.6779915690422058,)   \n",
       "2                      (CRP,)                     (0.6587790846824646,)   \n",
       "3                    (KLF12,)                     (0.8585225939750671,)   \n",
       "4             (MEP1A, ADGRF5)   (0.6522198915481567, 0.568143904209137)   \n",
       "...                       ...                                       ...   \n",
       "224101                     ()                                        ()   \n",
       "224102                     ()                                        ()   \n",
       "224103               (CAMK4,)                     (0.8918408751487732,)   \n",
       "224104                     ()                                        ()   \n",
       "224105              (CFAP53,)                     (0.8350275158882141,)   \n",
       "\n",
       "               bestLocus2GenesOrClosest_id bestLocus2GenesOrClosest_symbol  \\\n",
       "0       (ENSG00000112818, ENSG00000069122)                 (MEP1A, ADGRF5)   \n",
       "1                       (ENSG00000163132,)                         (MSX1,)   \n",
       "2                       (ENSG00000132693,)                          (CRP,)   \n",
       "3                       (ENSG00000118922,)                        (KLF12,)   \n",
       "4       (ENSG00000112818, ENSG00000069122)                 (MEP1A, ADGRF5)   \n",
       "...                                    ...                             ...   \n",
       "224101                  (ENSG00000188981,)                      (MSANTD1,)   \n",
       "224102                  (ENSG00000145839,)                          (IL9,)   \n",
       "224103                  (ENSG00000152495,)                        (CAMK4,)   \n",
       "224104                  (ENSG00000101574,)                       (METTL4,)   \n",
       "224105                  (ENSG00000172361,)                       (CFAP53,)   \n",
       "\n",
       "        pvalMantissa  pvalExponent  credibleSetSize  ldSetSize  totalSetSize  \\\n",
       "0              2.015            -8                2          0             2   \n",
       "1              4.990            -8                2         13            13   \n",
       "2              6.133           -10                3          4             4   \n",
       "3              4.023            -8                8          0             8   \n",
       "4              1.552            -9                2          0             2   \n",
       "...              ...           ...              ...        ...           ...   \n",
       "224101         2.950            -9               18          9            26   \n",
       "224102         3.990            -8                4          0             4   \n",
       "224103         1.810            -8                2          0             2   \n",
       "224104         3.340            -8                2          3             3   \n",
       "224105         4.110            -8               14         13            17   \n",
       "\n",
       "                pval          oddsRatio oddsRatioCILower  \\\n",
       "0       2.015000e-08  7938577976.443386   2763395.679138   \n",
       "1       4.990000e-08           0.552501         0.446371   \n",
       "2       6.133000e-10           0.874765         0.838461   \n",
       "3       4.023000e-08           1.997507         1.560296   \n",
       "4       1.552000e-09  20134487948.29578   9112823.906844   \n",
       "...              ...                ...              ...   \n",
       "224101  2.950000e-09           1.141108          1.09252   \n",
       "224102  3.990000e-08           2.083398         1.602164   \n",
       "224103  1.810000e-08           2.539583         1.834247   \n",
       "224104  3.340000e-08           1.388189         1.235621   \n",
       "224105  4.110000e-08           1.780688         1.449467   \n",
       "\n",
       "             oddsRatioCIUpper  beta betaCILower betaCIUpper direction  \\\n",
       "0       22805644795582.570312  None        None        None         +   \n",
       "1                    0.683865  None        None        None         -   \n",
       "2                    0.912641  None        None        None         -   \n",
       "3                     2.55723  None        None        None         +   \n",
       "4        44486496072376.03125  None        None        None         +   \n",
       "...                       ...   ...         ...         ...       ...   \n",
       "224101               1.191857  None        None        None         +   \n",
       "224102               2.709177  None        None        None         +   \n",
       "224103               3.516148  None        None        None         +   \n",
       "224104               1.559595  None        None        None         +   \n",
       "224105               2.187597  None        None        None         +   \n",
       "\n",
       "       variant_chromosome  variant_position variant_refAllele  \\\n",
       "0                       6          46877116                 T   \n",
       "1                       4           4864861                 A   \n",
       "2                       1         159743672                 A   \n",
       "3                      13          74291635                 C   \n",
       "4                       6          46877116                 T   \n",
       "...                   ...               ...               ...   \n",
       "224101                  4           3240118                 C   \n",
       "224102                  5         135834716                 T   \n",
       "224103                  5         111211885                 A   \n",
       "224104                 18           1777012                 G   \n",
       "224105                 18          50238751                 G   \n",
       "\n",
       "       variant_altAllele variant_rsId variant_chromosomeB37  \\\n",
       "0                      G         None                  None   \n",
       "1                      C    rs6825765                     4   \n",
       "2                      G   rs74596724                     1   \n",
       "3                      T  rs117832616                    13   \n",
       "4                      G         None                  None   \n",
       "...                  ...          ...                   ...   \n",
       "224101                 T     rs362307                     4   \n",
       "224102                 G  rs141243065                     5   \n",
       "224103                 G   rs72793560                     5   \n",
       "224104                 A    rs4600536                    18   \n",
       "224105                 C   rs35839946                    18   \n",
       "\n",
       "       variant_positionB37       variant_id variant_nearestGene  \\\n",
       "0                     None   6_46877116_T_G                None   \n",
       "1                  4866588    4_4864861_A_C                 NaN   \n",
       "2                159713462  1_159743672_A_G                 NaN   \n",
       "3                 74865772  13_74291635_C_T                 NaN   \n",
       "4                     None   6_46877116_T_G                None   \n",
       "...                    ...              ...                 ...   \n",
       "224101             3241845    4_3240118_C_T                 NaN   \n",
       "224102           135170405  5_135834716_T_G                 NaN   \n",
       "224103           110547583  5_111211885_A_G                 NaN   \n",
       "224104             1777013   18_1777012_G_A                 NaN   \n",
       "224105            47765121  18_50238751_G_C                 NaN   \n",
       "\n",
       "       variant_nearestGeneDistance variant_nearestCodingGene  \\\n",
       "0                             None                      None   \n",
       "1                             5196                       NaN   \n",
       "2                            29083                       NaN   \n",
       "3                            60178                       NaN   \n",
       "4                             None                      None   \n",
       "...                            ...                       ...   \n",
       "224101                        4251                       NaN   \n",
       "224102                       61111                       NaN   \n",
       "224103                       11768                       NaN   \n",
       "224104                        3317                       NaN   \n",
       "224105                       17710                       NaN   \n",
       "\n",
       "       variant_nearestCodingGeneDistance variant_mostSevereConsequence  \\\n",
       "0                                   None                          None   \n",
       "1                                   5196       downstream_gene_variant   \n",
       "2                                  29083            intergenic_variant   \n",
       "3                                 296579         upstream_gene_variant   \n",
       "4                                   None                          None   \n",
       "...                                  ...                           ...   \n",
       "224101                              4251           3_prime_UTR_variant   \n",
       "224102                             61111           5_prime_UTR_variant   \n",
       "224103                             11768            intergenic_variant   \n",
       "224104                            794497                intron_variant   \n",
       "224105                             27744                intron_variant   \n",
       "\n",
       "       variant_caddRaw variant_caddPhred variant_gnomadAFR variant_gnomadAMR  \\\n",
       "0                 None              None              None              None   \n",
       "1             0.129132             4.745          0.468369          0.612028   \n",
       "2             0.770176             11.64          0.011703          0.040094   \n",
       "3             -0.24534             0.528                 0          0.002358   \n",
       "4                 None              None              None              None   \n",
       "...                ...               ...               ...               ...   \n",
       "224101       -0.124826             1.185          0.014696          0.117925   \n",
       "224102         0.91253             12.69          0.000919          0.001179   \n",
       "224103        0.071646             3.792          0.003381           0.01706   \n",
       "224104       -0.054059             1.888          0.657676          0.453682   \n",
       "224105        0.606433             10.33          0.140313          0.206856   \n",
       "\n",
       "       variant_gnomadASJ variant_gnomadEAS variant_gnomadFIN  \\\n",
       "0                   None              None              None   \n",
       "1               0.375862          0.652706          0.601729   \n",
       "2               0.096552          0.164103          0.063364   \n",
       "3                      0          0.010296          0.003165   \n",
       "4                   None              None              None   \n",
       "...                  ...               ...               ...   \n",
       "224101          0.027586          0.001282          0.065055   \n",
       "224102          0.006897               0.0          0.000288   \n",
       "224103          0.024476               0.0          0.018482   \n",
       "224104          0.458621           0.47365          0.495109   \n",
       "224105          0.416667          0.060256          0.406936   \n",
       "\n",
       "       variant_gnomadNFE variant_gnomadNFEEST variant_gnomadNFENWE  \\\n",
       "0                   None                 None                 None   \n",
       "1               0.464031             0.508534             0.448545   \n",
       "2               0.075765             0.096288             0.067939   \n",
       "3               0.000519             0.001093             0.000116   \n",
       "4                   None                 None                 None   \n",
       "...                  ...                  ...                  ...   \n",
       "224101          0.081204             0.091266             0.079572   \n",
       "224102          0.004088             0.001532             0.005119   \n",
       "224103           0.02138             0.018255             0.023478   \n",
       "224104          0.478046             0.507909             0.461556   \n",
       "224105          0.396039             0.375599             0.404106   \n",
       "\n",
       "       variant_gnomadNFESEU variant_gnomadNFEONF variant_gnomadOTH  \\\n",
       "0                      None                 None              None   \n",
       "1                  0.443396             0.432116           0.48893   \n",
       "2                   0.09434             0.062324            0.0625   \n",
       "3                         0             0.000935                 0   \n",
       "4                      None                 None              None   \n",
       "...                     ...                  ...               ...   \n",
       "224101             0.084906             0.066011          0.069853   \n",
       "224102             0.009434             0.005145          0.004604   \n",
       "224103             0.018868             0.019712          0.022857   \n",
       "224104             0.481132             0.480319          0.534323   \n",
       "224105             0.396226             0.407598          0.360185   \n",
       "\n",
       "       variant_nearestGene_id variant_nearestGene_symbol  \\\n",
       "0                         NaN                        NaN   \n",
       "1             ENSG00000163132                       MSX1   \n",
       "2             ENSG00000132693                        CRP   \n",
       "3             ENSG00000235532                  LINC00402   \n",
       "4                         NaN                        NaN   \n",
       "...                       ...                        ...   \n",
       "224101        ENSG00000188981                    MSANTD1   \n",
       "224102        ENSG00000145839                        IL9   \n",
       "224103        ENSG00000152495                      CAMK4   \n",
       "224104        ENSG00000264080                 AP005057.1   \n",
       "224105        ENSG00000277310                 AC090246.1   \n",
       "\n",
       "       variant_nearestGene_bioType  \\\n",
       "0                              NaN   \n",
       "1                   protein_coding   \n",
       "2                   protein_coding   \n",
       "3                          lincRNA   \n",
       "4                              NaN   \n",
       "...                            ...   \n",
       "224101              protein_coding   \n",
       "224102              protein_coding   \n",
       "224103              protein_coding   \n",
       "224104                     lincRNA   \n",
       "224105              sense_intronic   \n",
       "\n",
       "                          variant_nearestGene_description  \\\n",
       "0                                                     NaN   \n",
       "1       msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "2       C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "3       long intergenic non-protein coding RNA 402 [So...   \n",
       "4                                                     NaN   \n",
       "...                                                   ...   \n",
       "224101  Myb/SANT DNA binding domain containing 1 [Sour...   \n",
       "224102   interleukin 9 [Source:HGNC Symbol;Acc:HGNC:6029]   \n",
       "224103  calcium/calmodulin dependent protein kinase IV...   \n",
       "224104                                   novel transcript   \n",
       "224105         novel transcript, sense intronic to CCDC11   \n",
       "\n",
       "       variant_nearestGene_chromosome  variant_nearestGene_tss  \\\n",
       "0                                 NaN                      NaN   \n",
       "1                                   4                4859665.0   \n",
       "2                                   1              159714589.0   \n",
       "3                                  13               74231457.0   \n",
       "4                                 NaN                      NaN   \n",
       "...                               ...                      ...   \n",
       "224101                              4                3244369.0   \n",
       "224102                              5              135895827.0   \n",
       "224103                              5              111223653.0   \n",
       "224104                             18                1780329.0   \n",
       "224105                             18               50256461.0   \n",
       "\n",
       "        variant_nearestGene_start  variant_nearestGene_end  \\\n",
       "0                             NaN                      NaN   \n",
       "1                       4859665.0                4863936.0   \n",
       "2                     159712289.0              159714589.0   \n",
       "3                      74231457.0               74259976.0   \n",
       "4                             NaN                      NaN   \n",
       "...                           ...                      ...   \n",
       "224101                  3244369.0                3271738.0   \n",
       "224102                135892246.0              135895827.0   \n",
       "224103                111223653.0              111494886.0   \n",
       "224104                  1780329.0                1782064.0   \n",
       "224105                 50256036.0               50256461.0   \n",
       "\n",
       "       variant_nearestGene_fwdStrand  \\\n",
       "0                                NaN   \n",
       "1                               True   \n",
       "2                              False   \n",
       "3                               True   \n",
       "4                                NaN   \n",
       "...                              ...   \n",
       "224101                          True   \n",
       "224102                         False   \n",
       "224103                          True   \n",
       "224104                          True   \n",
       "224105                         False   \n",
       "\n",
       "                                variant_nearestGene_exons  \\\n",
       "0                                                     NaN   \n",
       "1                    [4862701, 4863936, 4859665, 4860368]   \n",
       "2            [159714425, 159714589, 159712289, 159714138]   \n",
       "3                [74256933, 74259976, 74231457, 74231752]   \n",
       "4                                                     NaN   \n",
       "...                                                   ...   \n",
       "224101  [3255725, 3256613, 3253207, 3253482, 3249159, ...   \n",
       "224102  [135895440, 135895472, 135895555, 135895590, 1...   \n",
       "224103  [111484026, 111494886, 111394710, 111394782, 1...   \n",
       "224104  [1781714, 1782064, 1780578, 1780639, 1780329, ...   \n",
       "224105                               [50256036, 50256461]   \n",
       "\n",
       "       variant_nearestCodingGene_id variant_nearestCodingGene_symbol  \\\n",
       "0                               NaN                              NaN   \n",
       "1                   ENSG00000163132                             MSX1   \n",
       "2                   ENSG00000132693                              CRP   \n",
       "3                   ENSG00000118922                            KLF12   \n",
       "4                               NaN                              NaN   \n",
       "...                             ...                              ...   \n",
       "224101              ENSG00000188981                          MSANTD1   \n",
       "224102              ENSG00000145839                              IL9   \n",
       "224103              ENSG00000152495                            CAMK4   \n",
       "224104              ENSG00000101574                           METTL4   \n",
       "224105              ENSG00000172361                           CFAP53   \n",
       "\n",
       "       variant_nearestCodingGene_bioType  \\\n",
       "0                                    NaN   \n",
       "1                         protein_coding   \n",
       "2                         protein_coding   \n",
       "3                         protein_coding   \n",
       "4                                    NaN   \n",
       "...                                  ...   \n",
       "224101                    protein_coding   \n",
       "224102                    protein_coding   \n",
       "224103                    protein_coding   \n",
       "224104                    protein_coding   \n",
       "224105                    protein_coding   \n",
       "\n",
       "                    variant_nearestCodingGene_description  \\\n",
       "0                                                     NaN   \n",
       "1       msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391]   \n",
       "2       C-reactive protein [Source:HGNC Symbol;Acc:HGN...   \n",
       "3       Kruppel like factor 12 [Source:HGNC Symbol;Acc...   \n",
       "4                                                     NaN   \n",
       "...                                                   ...   \n",
       "224101  Myb/SANT DNA binding domain containing 1 [Sour...   \n",
       "224102   interleukin 9 [Source:HGNC Symbol;Acc:HGNC:6029]   \n",
       "224103  calcium/calmodulin dependent protein kinase IV...   \n",
       "224104  methyltransferase like 4 [Source:HGNC Symbol;A...   \n",
       "224105  cilia and flagella associated protein 53 [Sour...   \n",
       "\n",
       "       variant_nearestCodingGene_chromosome  variant_nearestCodingGene_tss  \\\n",
       "0                                       NaN                            NaN   \n",
       "1                                         4                      4859665.0   \n",
       "2                                         1                    159714589.0   \n",
       "3                                        13                     73995056.0   \n",
       "4                                       NaN                            NaN   \n",
       "...                                     ...                            ...   \n",
       "224101                                    4                      3244369.0   \n",
       "224102                                    5                    135895827.0   \n",
       "224103                                    5                    111223653.0   \n",
       "224104                                   18                      2571509.0   \n",
       "224105                                   18                     50266495.0   \n",
       "\n",
       "        variant_nearestCodingGene_start  variant_nearestCodingGene_end  \\\n",
       "0                                   NaN                            NaN   \n",
       "1                             4859665.0                      4863936.0   \n",
       "2                           159712289.0                    159714589.0   \n",
       "3                            73686089.0                     73995056.0   \n",
       "4                                   NaN                            NaN   \n",
       "...                                 ...                            ...   \n",
       "224101                        3244369.0                      3271738.0   \n",
       "224102                      135892246.0                    135895827.0   \n",
       "224103                      111223653.0                    111494886.0   \n",
       "224104                        2537525.0                      2571509.0   \n",
       "224105                       50227193.0                     50266495.0   \n",
       "\n",
       "       variant_nearestCodingGene_fwdStrand  \\\n",
       "0                                      NaN   \n",
       "1                                     True   \n",
       "2                                    False   \n",
       "3                                    False   \n",
       "4                                      NaN   \n",
       "...                                    ...   \n",
       "224101                                True   \n",
       "224102                               False   \n",
       "224103                                True   \n",
       "224104                               False   \n",
       "224105                               False   \n",
       "\n",
       "                          variant_nearestCodingGene_exons  \n",
       "0                                                     NaN  \n",
       "1                    [4862701, 4863936, 4859665, 4860368]  \n",
       "2            [159714425, 159714589, 159712289, 159714138]  \n",
       "3       [73686089, 73695671, 73715368, 73715525, 73764...  \n",
       "4                                                     NaN  \n",
       "...                                                   ...  \n",
       "224101  [3255725, 3256613, 3253207, 3253482, 3249159, ...  \n",
       "224102  [135895440, 135895472, 135895555, 135895590, 1...  \n",
       "224103  [111484026, 111494886, 111394710, 111394782, 1...  \n",
       "224104  [2537530, 2539145, 2544195, 2544286, 2544653, ...  \n",
       "224105  [50227193, 50227609, 50238603, 50238705, 50242...  \n",
       "\n",
       "[224106 rows x 69 columns]"
      ]
     },
     "execution_count": 78,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 79,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['Uncategorised',\n",
       " 'biological process',\n",
       " 'cardiovascular disease',\n",
       " 'cell proliferation disorder',\n",
       " 'disease of ear',\n",
       " 'disease of visual system',\n",
       " 'endocrine system disease',\n",
       " 'gastrointestinal disease',\n",
       " 'genetic, familial or congenital disease',\n",
       " 'hematologic disease',\n",
       " 'immune system disease',\n",
       " 'infectious disease',\n",
       " 'injury, poisoning or other complication',\n",
       " 'integumentary system disease',\n",
       " 'measurement',\n",
       " 'musculoskeletal or connective tissue disease',\n",
       " 'nervous system disease',\n",
       " 'nutritional or metabolic disease',\n",
       " 'pancreas disease',\n",
       " 'phenotype',\n",
       " 'pregnancy or perinatal disease',\n",
       " 'psychiatric disorder',\n",
       " 'reproductive system or breast disease',\n",
       " 'respiratory or thoracic disease',\n",
       " 'urinary system disease']"
      ]
     },
     "execution_count": 79,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "sorted(info_df.traitCategory.unique())"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Add L2G and closest gene  info to info data frame as a list"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 80,
   "metadata": {},
   "outputs": [],
   "source": [
    "bestgenes_df.set_index('study', inplace=True)\n",
    "info_df.set_index('studyId', inplace=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 81,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_id</th>\n",
       "      <th>variant_bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_bestLocus2GenesOrClosest_id</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>study</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GHLAMY_OTHER</th>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>((MEP1A, ADGRF5), 6_46877116_T_G)</td>\n",
       "      <td>((ENSG00000112818, ENSG00000069122), 6_4687711...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_MEASLES</th>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "      <td>4_4864861_A_C</td>\n",
       "      <td>((MSX1,), 4_4864861_A_C)</td>\n",
       "      <td>((ENSG00000163132,), 4_4864861_A_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_BACTERIAL</th>\n",
       "      <td>(ENSG00000132693,)</td>\n",
       "      <td>(CRP,)</td>\n",
       "      <td>1_159743672_A_G</td>\n",
       "      <td>((CRP,), 1_159743672_A_G)</td>\n",
       "      <td>((ENSG00000132693,), 1_159743672_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_BACTERIAL</th>\n",
       "      <td>(ENSG00000118922,)</td>\n",
       "      <td>(KLF12,)</td>\n",
       "      <td>13_74291635_C_T</td>\n",
       "      <td>((KLF12,), 13_74291635_C_T)</td>\n",
       "      <td>((ENSG00000118922,), 13_74291635_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_CHLAMYDIAE</th>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>6_46877116_T_G</td>\n",
       "      <td>((MEP1A, ADGRF5), 6_46877116_T_G)</td>\n",
       "      <td>((ENSG00000112818, ENSG00000069122), 6_4687711...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_960_2</th>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "      <td>4_3240118_C_T</td>\n",
       "      <td>((MSANTD1,), 4_3240118_C_T)</td>\n",
       "      <td>((ENSG00000188981,), 4_3240118_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965</th>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "      <td>5_135834716_T_G</td>\n",
       "      <td>((IL9,), 5_135834716_T_G)</td>\n",
       "      <td>((ENSG00000145839,), 5_135834716_T_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965_1</th>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>5_111211885_A_G</td>\n",
       "      <td>((CAMK4,), 5_111211885_A_G)</td>\n",
       "      <td>((ENSG00000152495,), 5_111211885_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_967</th>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "      <td>18_1777012_G_A</td>\n",
       "      <td>((METTL4,), 18_1777012_G_A)</td>\n",
       "      <td>((ENSG00000101574,), 18_1777012_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_971</th>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "      <td>18_50238751_G_C</td>\n",
       "      <td>((CFAP53,), 18_50238751_G_C)</td>\n",
       "      <td>((ENSG00000172361,), 18_50238751_G_C)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>224106 rows × 5 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                        bestLocus2GenesOrClosest_id  \\\n",
       "study                                                                 \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER      (ENSG00000112818, ENSG00000069122)   \n",
       "FINNGEN_R5_AB1_MEASLES                           (ENSG00000163132,)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                   (ENSG00000132693,)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                   (ENSG00000118922,)   \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE  (ENSG00000112818, ENSG00000069122)   \n",
       "...                                                             ...   \n",
       "SAIGE_960_2                                      (ENSG00000188981,)   \n",
       "SAIGE_965                                        (ENSG00000145839,)   \n",
       "SAIGE_965_1                                      (ENSG00000152495,)   \n",
       "SAIGE_967                                        (ENSG00000101574,)   \n",
       "SAIGE_971                                        (ENSG00000172361,)   \n",
       "\n",
       "                                bestLocus2GenesOrClosest_symbol  \\\n",
       "study                                                             \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                     (MEP1A, ADGRF5)   \n",
       "FINNGEN_R5_AB1_MEASLES                                  (MSX1,)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                           (CRP,)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                         (KLF12,)   \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE                 (MEP1A, ADGRF5)   \n",
       "...                                                         ...   \n",
       "SAIGE_960_2                                          (MSANTD1,)   \n",
       "SAIGE_965                                                (IL9,)   \n",
       "SAIGE_965_1                                            (CAMK4,)   \n",
       "SAIGE_967                                             (METTL4,)   \n",
       "SAIGE_971                                             (CFAP53,)   \n",
       "\n",
       "                                      variant_id  \\\n",
       "study                                              \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER       6_46877116_T_G   \n",
       "FINNGEN_R5_AB1_MEASLES             4_4864861_A_C   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL   1_159743672_A_G   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL   13_74291635_C_T   \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE   6_46877116_T_G   \n",
       "...                                          ...   \n",
       "SAIGE_960_2                        4_3240118_C_T   \n",
       "SAIGE_965                        5_135834716_T_G   \n",
       "SAIGE_965_1                      5_111211885_A_G   \n",
       "SAIGE_967                         18_1777012_G_A   \n",
       "SAIGE_971                        18_50238751_G_C   \n",
       "\n",
       "                                variant_bestLocus2GenesOrClosest_symbol  \\\n",
       "study                                                                     \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER           ((MEP1A, ADGRF5), 6_46877116_T_G)   \n",
       "FINNGEN_R5_AB1_MEASLES                         ((MSX1,), 4_4864861_A_C)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                ((CRP,), 1_159743672_A_G)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL              ((KLF12,), 13_74291635_C_T)   \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE       ((MEP1A, ADGRF5), 6_46877116_T_G)   \n",
       "...                                                                 ...   \n",
       "SAIGE_960_2                                 ((MSANTD1,), 4_3240118_C_T)   \n",
       "SAIGE_965                                     ((IL9,), 5_135834716_T_G)   \n",
       "SAIGE_965_1                                 ((CAMK4,), 5_111211885_A_G)   \n",
       "SAIGE_967                                   ((METTL4,), 18_1777012_G_A)   \n",
       "SAIGE_971                                  ((CFAP53,), 18_50238751_G_C)   \n",
       "\n",
       "                                               variant_bestLocus2GenesOrClosest_id  \n",
       "study                                                                               \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER      ((ENSG00000112818, ENSG00000069122), 6_4687711...  \n",
       "FINNGEN_R5_AB1_MEASLES                         ((ENSG00000163132,), 4_4864861_A_C)  \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL               ((ENSG00000132693,), 1_159743672_A_G)  \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL               ((ENSG00000118922,), 13_74291635_C_T)  \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE  ((ENSG00000112818, ENSG00000069122), 6_4687711...  \n",
       "...                                                                            ...  \n",
       "SAIGE_960_2                                    ((ENSG00000188981,), 4_3240118_C_T)  \n",
       "SAIGE_965                                    ((ENSG00000145839,), 5_135834716_T_G)  \n",
       "SAIGE_965_1                                  ((ENSG00000152495,), 5_111211885_A_G)  \n",
       "SAIGE_967                                     ((ENSG00000101574,), 18_1777012_G_A)  \n",
       "SAIGE_971                                    ((ENSG00000172361,), 18_50238751_G_C)  \n",
       "\n",
       "[224106 rows x 5 columns]"
      ]
     },
     "execution_count": 81,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df['variant_bestLocus2GenesOrClosest_symbol'] = list(zip(bestgenes_df.bestLocus2GenesOrClosest_symbol, bestgenes_df.variant_id))\n",
    "bestgenes_df['variant_bestLocus2GenesOrClosest_id'] = list(zip(bestgenes_df.bestLocus2GenesOrClosest_id, bestgenes_df.variant_id))\n",
    "\n",
    "bestgenes_df[['bestLocus2GenesOrClosest_id', 'bestLocus2GenesOrClosest_symbol', 'variant_id', 'variant_bestLocus2GenesOrClosest_symbol', 'variant_bestLocus2GenesOrClosest_id']]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 82,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>study</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GHLAMY_OTHER</th>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_MEASLES</th>\n",
       "      <td>(ENSG00000163132,)</td>\n",
       "      <td>(MSX1,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_BACTERIAL</th>\n",
       "      <td>(ENSG00000132693, ENSG00000118922)</td>\n",
       "      <td>(CRP, KLF12)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_CHLAMYDIAE</th>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_OTHER_SPIROCHAETAL</th>\n",
       "      <td>(ENSG00000135316,)</td>\n",
       "      <td>(SYNCRIP,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_960_2</th>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965</th>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965_1</th>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_967</th>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_971</th>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>16485 rows × 2 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                          bestLocus2GenesOrClosest_id  \\\n",
       "study                                                                   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER        (ENSG00000112818, ENSG00000069122)   \n",
       "FINNGEN_R5_AB1_MEASLES                             (ENSG00000163132,)   \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL     (ENSG00000132693, ENSG00000118922)   \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE    (ENSG00000112818, ENSG00000069122)   \n",
       "FINNGEN_R5_AB1_OTHER_SPIROCHAETAL                  (ENSG00000135316,)   \n",
       "...                                                               ...   \n",
       "SAIGE_960_2                                        (ENSG00000188981,)   \n",
       "SAIGE_965                                          (ENSG00000145839,)   \n",
       "SAIGE_965_1                                        (ENSG00000152495,)   \n",
       "SAIGE_967                                          (ENSG00000101574,)   \n",
       "SAIGE_971                                          (ENSG00000172361,)   \n",
       "\n",
       "                                  bestLocus2GenesOrClosest_symbol  \n",
       "study                                                              \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                       (MEP1A, ADGRF5)  \n",
       "FINNGEN_R5_AB1_MEASLES                                    (MSX1,)  \n",
       "FINNGEN_R5_AB1_OTHER_BACTERIAL                       (CRP, KLF12)  \n",
       "FINNGEN_R5_AB1_OTHER_CHLAMYDIAE                   (MEP1A, ADGRF5)  \n",
       "FINNGEN_R5_AB1_OTHER_SPIROCHAETAL                      (SYNCRIP,)  \n",
       "...                                                           ...  \n",
       "SAIGE_960_2                                            (MSANTD1,)  \n",
       "SAIGE_965                                                  (IL9,)  \n",
       "SAIGE_965_1                                              (CAMK4,)  \n",
       "SAIGE_967                                               (METTL4,)  \n",
       "SAIGE_971                                               (CFAP53,)  \n",
       "\n",
       "[16485 rows x 2 columns]"
      ]
     },
     "execution_count": 82,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.groupby('study')[['bestLocus2GenesOrClosest_id', 'bestLocus2GenesOrClosest_symbol']].agg(lambda x: tuple([i for y in x for i in y]))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 83,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>traitReported</th>\n",
       "      <th>source</th>\n",
       "      <th>traitEfos</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pubDate</th>\n",
       "      <th>pubJournal</th>\n",
       "      <th>pubTitle</th>\n",
       "      <th>pubAuthor</th>\n",
       "      <th>hasSumstats</th>\n",
       "      <th>ancestryInitial</th>\n",
       "      <th>ancestryReplication</th>\n",
       "      <th>nInitial</th>\n",
       "      <th>nReplication</th>\n",
       "      <th>nCases</th>\n",
       "      <th>traitCategory</th>\n",
       "      <th>numAssocLoci</th>\n",
       "      <th>nTotal</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>studyId</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_BACTINF_NOS</th>\n",
       "      <td>\"Bacterial infection, other or unspecified\"</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0000771]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218637]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218637</td>\n",
       "      <td>0</td>\n",
       "      <td>20977</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>2</td>\n",
       "      <td>218637</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_DERMATOPHYTOSIS</th>\n",
       "      <td>Dermatophytosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0004678]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=216472]</td>\n",
       "      <td>[]</td>\n",
       "      <td>216472</td>\n",
       "      <td>0</td>\n",
       "      <td>1656</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>216472</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_EBV</th>\n",
       "      <td>Infectious mononucleosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0007326]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=214904]</td>\n",
       "      <td>[]</td>\n",
       "      <td>214904</td>\n",
       "      <td>0</td>\n",
       "      <td>1238</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>214904</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GASTROENTERITIS_NOS</th>\n",
       "      <td>Diarrhoea and gastroenteritis of presumed infe...</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0045031]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=212553]</td>\n",
       "      <td>[]</td>\n",
       "      <td>212553</td>\n",
       "      <td>0</td>\n",
       "      <td>15255</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>212553</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GHLAMY_OTHER</th>\n",
       "      <td>Other diseases caused by chlamydiae</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_1001288]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218772]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218772</td>\n",
       "      <td>0</td>\n",
       "      <td>167</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>218772</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_960_2</th>\n",
       "      <td>Allergy/adverse effect of penicillin</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=397887]</td>\n",
       "      <td>[]</td>\n",
       "      <td>397887</td>\n",
       "      <td>0</td>\n",
       "      <td>16090</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>397887</td>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965</th>\n",
       "      <td>Poisoning by analgesics, antipyretics, and ant...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=388707]</td>\n",
       "      <td>[]</td>\n",
       "      <td>388707</td>\n",
       "      <td>0</td>\n",
       "      <td>6910</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>388707</td>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965_1</th>\n",
       "      <td>Opiates and related narcotics causing adverse ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382947]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382947</td>\n",
       "      <td>0</td>\n",
       "      <td>1150</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382947</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_967</th>\n",
       "      <td>Adverse effects of sedatives or other central ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382385]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382385</td>\n",
       "      <td>0</td>\n",
       "      <td>588</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382385</td>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_971</th>\n",
       "      <td>Poisoning by drugs primarily affecting the aut...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=381988]</td>\n",
       "      <td>[]</td>\n",
       "      <td>381988</td>\n",
       "      <td>0</td>\n",
       "      <td>191</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>381988</td>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>17054 rows × 19 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                                                        traitReported  \\\n",
       "studyId                                                                                 \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                \"Bacterial infection, other or unspecified\"   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                        Dermatophytosis   \n",
       "FINNGEN_R5_AB1_EBV                                           Infectious mononucleosis   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  Diarrhoea and gastroenteritis of presumed infe...   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                       Other diseases caused by chlamydiae   \n",
       "...                                                                               ...   \n",
       "SAIGE_960_2                                      Allergy/adverse effect of penicillin   \n",
       "SAIGE_965                           Poisoning by analgesics, antipyretics, and ant...   \n",
       "SAIGE_965_1                         Opiates and related narcotics causing adverse ...   \n",
       "SAIGE_967                           Adverse effects of sedatives or other central ...   \n",
       "SAIGE_971                           Poisoning by drugs primarily affecting the aut...   \n",
       "\n",
       "                                     source        traitEfos  pmid  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN    [EFO_0000771]  None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN  [MONDO_0004678]  None   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN    [EFO_0007326]  None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN  [MONDO_0045031]  None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN    [EFO_1001288]  None   \n",
       "...                                     ...              ...   ...   \n",
       "SAIGE_960_2                           SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965                             SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965_1                           SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_967                             SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_971                             SAIGE    [EFO_0008546]  None   \n",
       "\n",
       "                                       pubDate pubJournal pubTitle  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_EBV                  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         2021-05-11       None     None   \n",
       "...                                        ...        ...      ...   \n",
       "SAIGE_960_2                         2018-10-24       None     None   \n",
       "SAIGE_965                           2018-10-24       None     None   \n",
       "SAIGE_965_1                         2018-10-24       None     None   \n",
       "SAIGE_967                           2018-10-24       None     None   \n",
       "SAIGE_971                           2018-10-24       None     None   \n",
       "\n",
       "                                     pubAuthor  hasSumstats  \\\n",
       "studyId                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN_R5         True   \n",
       "...                                        ...          ...   \n",
       "SAIGE_960_2                          UKB SAIGE         True   \n",
       "SAIGE_965                            UKB SAIGE         True   \n",
       "SAIGE_965_1                          UKB SAIGE         True   \n",
       "SAIGE_967                            UKB SAIGE         True   \n",
       "SAIGE_971                            UKB SAIGE         True   \n",
       "\n",
       "                                      ancestryInitial ancestryReplication  \\\n",
       "studyId                                                                     \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          [European=218637]                  []   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      [European=216472]                  []   \n",
       "FINNGEN_R5_AB1_EBV                  [European=214904]                  []   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  [European=212553]                  []   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         [European=218772]                  []   \n",
       "...                                               ...                 ...   \n",
       "SAIGE_960_2                         [European=397887]                  []   \n",
       "SAIGE_965                           [European=388707]                  []   \n",
       "SAIGE_965_1                         [European=382947]                  []   \n",
       "SAIGE_967                           [European=382385]                  []   \n",
       "SAIGE_971                           [European=381988]                  []   \n",
       "\n",
       "                                    nInitial nReplication nCases  \\\n",
       "studyId                                                            \n",
       "FINNGEN_R5_AB1_BACTINF_NOS            218637            0  20977   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS        216472            0   1656   \n",
       "FINNGEN_R5_AB1_EBV                    214904            0   1238   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS    212553            0  15255   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER           218772            0    167   \n",
       "...                                      ...          ...    ...   \n",
       "SAIGE_960_2                           397887            0  16090   \n",
       "SAIGE_965                             388707            0   6910   \n",
       "SAIGE_965_1                           382947            0   1150   \n",
       "SAIGE_967                             382385            0    588   \n",
       "SAIGE_971                             381988            0    191   \n",
       "\n",
       "                                                              traitCategory  \\\n",
       "studyId                                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                               infectious disease   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                           infectious disease   \n",
       "FINNGEN_R5_AB1_EBV                                       infectious disease   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                       infectious disease   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                              infectious disease   \n",
       "...                                                                     ...   \n",
       "SAIGE_960_2                         injury, poisoning or other complication   \n",
       "SAIGE_965                           injury, poisoning or other complication   \n",
       "SAIGE_965_1                         injury, poisoning or other complication   \n",
       "SAIGE_967                           injury, poisoning or other complication   \n",
       "SAIGE_971                           injury, poisoning or other complication   \n",
       "\n",
       "                                    numAssocLoci  nTotal  \\\n",
       "studyId                                                    \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                     2  218637   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                 1  216472   \n",
       "FINNGEN_R5_AB1_EBV                             1  214904   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS             1  212553   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                    1  218772   \n",
       "...                                          ...     ...   \n",
       "SAIGE_960_2                                    1  397887   \n",
       "SAIGE_965                                      1  388707   \n",
       "SAIGE_965_1                                    1  382947   \n",
       "SAIGE_967                                      1  382385   \n",
       "SAIGE_971                                      1  381988   \n",
       "\n",
       "                                           bestLocus2GenesOrClosest_id  \\\n",
       "studyId                                                                  \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                         NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                     NaN   \n",
       "FINNGEN_R5_AB1_EBV                                                 NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                 NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (ENSG00000112818, ENSG00000069122)   \n",
       "...                                                                ...   \n",
       "SAIGE_960_2                                         (ENSG00000188981,)   \n",
       "SAIGE_965                                           (ENSG00000145839,)   \n",
       "SAIGE_965_1                                         (ENSG00000152495,)   \n",
       "SAIGE_967                                           (ENSG00000101574,)   \n",
       "SAIGE_971                                           (ENSG00000172361,)   \n",
       "\n",
       "                                   bestLocus2GenesOrClosest_symbol  \n",
       "studyId                                                             \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                     NaN  \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                 NaN  \n",
       "FINNGEN_R5_AB1_EBV                                             NaN  \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                             NaN  \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                        (MEP1A, ADGRF5)  \n",
       "...                                                            ...  \n",
       "SAIGE_960_2                                             (MSANTD1,)  \n",
       "SAIGE_965                                                   (IL9,)  \n",
       "SAIGE_965_1                                               (CAMK4,)  \n",
       "SAIGE_967                                                (METTL4,)  \n",
       "SAIGE_971                                                (CFAP53,)  \n",
       "\n",
       "[17054 rows x 19 columns]"
      ]
     },
     "execution_count": 83,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "info_df = info_df.join(bestgenes_df.groupby('study')[['bestLocus2GenesOrClosest_id', 'bestLocus2GenesOrClosest_symbol']].agg(lambda x: tuple([i for y in x for i in y])), how='left')\n",
    "info_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 84,
   "metadata": {},
   "outputs": [],
   "source": [
    "info_df['variant_gene_id_pairs'] = bestgenes_df.groupby('study')[['variant_bestLocus2GenesOrClosest_id']].agg(tuple)\n",
    "info_df['variant_gene_symbol_pairs'] = bestgenes_df.groupby('study')[['variant_bestLocus2GenesOrClosest_symbol']].agg(tuple)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 85,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>traitReported</th>\n",
       "      <th>source</th>\n",
       "      <th>traitEfos</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pubDate</th>\n",
       "      <th>pubJournal</th>\n",
       "      <th>pubTitle</th>\n",
       "      <th>pubAuthor</th>\n",
       "      <th>hasSumstats</th>\n",
       "      <th>ancestryInitial</th>\n",
       "      <th>ancestryReplication</th>\n",
       "      <th>nInitial</th>\n",
       "      <th>nReplication</th>\n",
       "      <th>nCases</th>\n",
       "      <th>traitCategory</th>\n",
       "      <th>numAssocLoci</th>\n",
       "      <th>nTotal</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_gene_id_pairs</th>\n",
       "      <th>variant_gene_symbol_pairs</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>studyId</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_BACTINF_NOS</th>\n",
       "      <td>\"Bacterial infection, other or unspecified\"</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0000771]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218637]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218637</td>\n",
       "      <td>0</td>\n",
       "      <td>20977</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>2</td>\n",
       "      <td>218637</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_DERMATOPHYTOSIS</th>\n",
       "      <td>Dermatophytosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0004678]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=216472]</td>\n",
       "      <td>[]</td>\n",
       "      <td>216472</td>\n",
       "      <td>0</td>\n",
       "      <td>1656</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>216472</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_EBV</th>\n",
       "      <td>Infectious mononucleosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0007326]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=214904]</td>\n",
       "      <td>[]</td>\n",
       "      <td>214904</td>\n",
       "      <td>0</td>\n",
       "      <td>1238</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>214904</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GASTROENTERITIS_NOS</th>\n",
       "      <td>Diarrhoea and gastroenteritis of presumed infe...</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0045031]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=212553]</td>\n",
       "      <td>[]</td>\n",
       "      <td>212553</td>\n",
       "      <td>0</td>\n",
       "      <td>15255</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>212553</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GHLAMY_OTHER</th>\n",
       "      <td>Other diseases caused by chlamydiae</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_1001288]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218772]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218772</td>\n",
       "      <td>0</td>\n",
       "      <td>167</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>218772</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(((ENSG00000112818, ENSG00000069122), 6_468771...</td>\n",
       "      <td>(((MEP1A, ADGRF5), 6_46877116_T_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_960_2</th>\n",
       "      <td>Allergy/adverse effect of penicillin</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=397887]</td>\n",
       "      <td>[]</td>\n",
       "      <td>397887</td>\n",
       "      <td>0</td>\n",
       "      <td>16090</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>397887</td>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "      <td>(((ENSG00000188981,), 4_3240118_C_T),)</td>\n",
       "      <td>(((MSANTD1,), 4_3240118_C_T),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965</th>\n",
       "      <td>Poisoning by analgesics, antipyretics, and ant...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=388707]</td>\n",
       "      <td>[]</td>\n",
       "      <td>388707</td>\n",
       "      <td>0</td>\n",
       "      <td>6910</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>388707</td>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "      <td>(((ENSG00000145839,), 5_135834716_T_G),)</td>\n",
       "      <td>(((IL9,), 5_135834716_T_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965_1</th>\n",
       "      <td>Opiates and related narcotics causing adverse ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382947]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382947</td>\n",
       "      <td>0</td>\n",
       "      <td>1150</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382947</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>(((ENSG00000152495,), 5_111211885_A_G),)</td>\n",
       "      <td>(((CAMK4,), 5_111211885_A_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_967</th>\n",
       "      <td>Adverse effects of sedatives or other central ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382385]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382385</td>\n",
       "      <td>0</td>\n",
       "      <td>588</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382385</td>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "      <td>(((ENSG00000101574,), 18_1777012_G_A),)</td>\n",
       "      <td>(((METTL4,), 18_1777012_G_A),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_971</th>\n",
       "      <td>Poisoning by drugs primarily affecting the aut...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=381988]</td>\n",
       "      <td>[]</td>\n",
       "      <td>381988</td>\n",
       "      <td>0</td>\n",
       "      <td>191</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>381988</td>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "      <td>(((ENSG00000172361,), 18_50238751_G_C),)</td>\n",
       "      <td>(((CFAP53,), 18_50238751_G_C),)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>17054 rows × 21 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                                                        traitReported  \\\n",
       "studyId                                                                                 \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                \"Bacterial infection, other or unspecified\"   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                        Dermatophytosis   \n",
       "FINNGEN_R5_AB1_EBV                                           Infectious mononucleosis   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  Diarrhoea and gastroenteritis of presumed infe...   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                       Other diseases caused by chlamydiae   \n",
       "...                                                                               ...   \n",
       "SAIGE_960_2                                      Allergy/adverse effect of penicillin   \n",
       "SAIGE_965                           Poisoning by analgesics, antipyretics, and ant...   \n",
       "SAIGE_965_1                         Opiates and related narcotics causing adverse ...   \n",
       "SAIGE_967                           Adverse effects of sedatives or other central ...   \n",
       "SAIGE_971                           Poisoning by drugs primarily affecting the aut...   \n",
       "\n",
       "                                     source        traitEfos  pmid  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN    [EFO_0000771]  None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN  [MONDO_0004678]  None   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN    [EFO_0007326]  None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN  [MONDO_0045031]  None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN    [EFO_1001288]  None   \n",
       "...                                     ...              ...   ...   \n",
       "SAIGE_960_2                           SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965                             SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965_1                           SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_967                             SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_971                             SAIGE    [EFO_0008546]  None   \n",
       "\n",
       "                                       pubDate pubJournal pubTitle  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_EBV                  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         2021-05-11       None     None   \n",
       "...                                        ...        ...      ...   \n",
       "SAIGE_960_2                         2018-10-24       None     None   \n",
       "SAIGE_965                           2018-10-24       None     None   \n",
       "SAIGE_965_1                         2018-10-24       None     None   \n",
       "SAIGE_967                           2018-10-24       None     None   \n",
       "SAIGE_971                           2018-10-24       None     None   \n",
       "\n",
       "                                     pubAuthor  hasSumstats  \\\n",
       "studyId                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN_R5         True   \n",
       "...                                        ...          ...   \n",
       "SAIGE_960_2                          UKB SAIGE         True   \n",
       "SAIGE_965                            UKB SAIGE         True   \n",
       "SAIGE_965_1                          UKB SAIGE         True   \n",
       "SAIGE_967                            UKB SAIGE         True   \n",
       "SAIGE_971                            UKB SAIGE         True   \n",
       "\n",
       "                                      ancestryInitial ancestryReplication  \\\n",
       "studyId                                                                     \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          [European=218637]                  []   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      [European=216472]                  []   \n",
       "FINNGEN_R5_AB1_EBV                  [European=214904]                  []   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  [European=212553]                  []   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         [European=218772]                  []   \n",
       "...                                               ...                 ...   \n",
       "SAIGE_960_2                         [European=397887]                  []   \n",
       "SAIGE_965                           [European=388707]                  []   \n",
       "SAIGE_965_1                         [European=382947]                  []   \n",
       "SAIGE_967                           [European=382385]                  []   \n",
       "SAIGE_971                           [European=381988]                  []   \n",
       "\n",
       "                                    nInitial nReplication nCases  \\\n",
       "studyId                                                            \n",
       "FINNGEN_R5_AB1_BACTINF_NOS            218637            0  20977   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS        216472            0   1656   \n",
       "FINNGEN_R5_AB1_EBV                    214904            0   1238   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS    212553            0  15255   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER           218772            0    167   \n",
       "...                                      ...          ...    ...   \n",
       "SAIGE_960_2                           397887            0  16090   \n",
       "SAIGE_965                             388707            0   6910   \n",
       "SAIGE_965_1                           382947            0   1150   \n",
       "SAIGE_967                             382385            0    588   \n",
       "SAIGE_971                             381988            0    191   \n",
       "\n",
       "                                                              traitCategory  \\\n",
       "studyId                                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                               infectious disease   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                           infectious disease   \n",
       "FINNGEN_R5_AB1_EBV                                       infectious disease   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                       infectious disease   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                              infectious disease   \n",
       "...                                                                     ...   \n",
       "SAIGE_960_2                         injury, poisoning or other complication   \n",
       "SAIGE_965                           injury, poisoning or other complication   \n",
       "SAIGE_965_1                         injury, poisoning or other complication   \n",
       "SAIGE_967                           injury, poisoning or other complication   \n",
       "SAIGE_971                           injury, poisoning or other complication   \n",
       "\n",
       "                                    numAssocLoci  nTotal  \\\n",
       "studyId                                                    \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                     2  218637   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                 1  216472   \n",
       "FINNGEN_R5_AB1_EBV                             1  214904   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS             1  212553   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                    1  218772   \n",
       "...                                          ...     ...   \n",
       "SAIGE_960_2                                    1  397887   \n",
       "SAIGE_965                                      1  388707   \n",
       "SAIGE_965_1                                    1  382947   \n",
       "SAIGE_967                                      1  382385   \n",
       "SAIGE_971                                      1  381988   \n",
       "\n",
       "                                           bestLocus2GenesOrClosest_id  \\\n",
       "studyId                                                                  \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                         NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                     NaN   \n",
       "FINNGEN_R5_AB1_EBV                                                 NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                 NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (ENSG00000112818, ENSG00000069122)   \n",
       "...                                                                ...   \n",
       "SAIGE_960_2                                         (ENSG00000188981,)   \n",
       "SAIGE_965                                           (ENSG00000145839,)   \n",
       "SAIGE_965_1                                         (ENSG00000152495,)   \n",
       "SAIGE_967                                           (ENSG00000101574,)   \n",
       "SAIGE_971                                           (ENSG00000172361,)   \n",
       "\n",
       "                                   bestLocus2GenesOrClosest_symbol  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                     NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                 NaN   \n",
       "FINNGEN_R5_AB1_EBV                                             NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                             NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                        (MEP1A, ADGRF5)   \n",
       "...                                                            ...   \n",
       "SAIGE_960_2                                             (MSANTD1,)   \n",
       "SAIGE_965                                                   (IL9,)   \n",
       "SAIGE_965_1                                               (CAMK4,)   \n",
       "SAIGE_967                                                (METTL4,)   \n",
       "SAIGE_971                                                (CFAP53,)   \n",
       "\n",
       "                                                                variant_gene_id_pairs  \\\n",
       "studyId                                                                                 \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                                        NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                                    NaN   \n",
       "FINNGEN_R5_AB1_EBV                                                                NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                                NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (((ENSG00000112818, ENSG00000069122), 6_468771...   \n",
       "...                                                                               ...   \n",
       "SAIGE_960_2                                    (((ENSG00000188981,), 4_3240118_C_T),)   \n",
       "SAIGE_965                                    (((ENSG00000145839,), 5_135834716_T_G),)   \n",
       "SAIGE_965_1                                  (((ENSG00000152495,), 5_111211885_A_G),)   \n",
       "SAIGE_967                                     (((ENSG00000101574,), 18_1777012_G_A),)   \n",
       "SAIGE_971                                    (((ENSG00000172361,), 18_50238751_G_C),)   \n",
       "\n",
       "                                               variant_gene_symbol_pairs  \n",
       "studyId                                                                   \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                           NaN  \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                       NaN  \n",
       "FINNGEN_R5_AB1_EBV                                                   NaN  \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                   NaN  \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (((MEP1A, ADGRF5), 6_46877116_T_G),)  \n",
       "...                                                                  ...  \n",
       "SAIGE_960_2                               (((MSANTD1,), 4_3240118_C_T),)  \n",
       "SAIGE_965                                   (((IL9,), 5_135834716_T_G),)  \n",
       "SAIGE_965_1                               (((CAMK4,), 5_111211885_A_G),)  \n",
       "SAIGE_967                                 (((METTL4,), 18_1777012_G_A),)  \n",
       "SAIGE_971                                (((CFAP53,), 18_50238751_G_C),)  \n",
       "\n",
       "[17054 rows x 21 columns]"
      ]
     },
     "execution_count": 85,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "info_df"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Remove duplicates in gene lists using the ids as reference"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 86,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/home/gokcen/.miniconda3/lib/python3.8/site-packages/pandas/core/computation/expressions.py:204: UserWarning: evaluating in Python space because the '+' operator is not supported by numexpr for the bool dtype, use '|' instead\n",
      "  warnings.warn(\n"
     ]
    }
   ],
   "source": [
    "duplicates = [pd.Series(x).duplicated() + pd.Series(x).isnull() for x in info_df.bestLocus2GenesOrClosest_id]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 87,
   "metadata": {},
   "outputs": [],
   "source": [
    "info_df['bestLocus2GenesOrClosest_id'] = [tuple(np.array(i)[~dup]) if not pd.isnull(i) and i != 'nan' else i for dup, i in zip(duplicates, info_df['bestLocus2GenesOrClosest_id'])]\n",
    "info_df['bestLocus2GenesOrClosest_symbol'] = [tuple(np.array(i)[~dup]) if not pd.isnull(i) and i != 'nan' else i for dup, i in zip(duplicates, info_df['bestLocus2GenesOrClosest_symbol'])]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 88,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 88,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "'nan' in info_df[~info_df.bestLocus2GenesOrClosest_id.isnull()].explode('bestLocus2GenesOrClosest_id').bestLocus2GenesOrClosest_id.unique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 89,
   "metadata": {},
   "outputs": [],
   "source": [
    "assert info_df[~info_df.bestLocus2GenesOrClosest_id.isnull()].explode('bestLocus2GenesOrClosest_id').bestLocus2GenesOrClosest_id.isna().sum() == 0"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 90,
   "metadata": {},
   "outputs": [],
   "source": [
    "info_df.traitReported = info_df.traitReported.str.replace('\"', '').str.replace('Õ', \"'\").str.replace('Ê', '') # Sanitize FINNGEN trait names until https://github.com/FINNGEN/pheweb/issues/142 is fixed"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 91,
   "metadata": {},
   "outputs": [],
   "source": [
    "assert np.all([len(x) if not pd.isnull(x) else 0 for x in info_df['bestLocus2GenesOrClosest_id']] == [len(x) if not pd.isnull(x) else 0 for x in info_df['bestLocus2GenesOrClosest_symbol']])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Sanity check"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 92,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>bestLocus2Genes_id</th>\n",
       "      <th>variant_nearestCodingGene_id</th>\n",
       "      <th>bestLocus2Genes_symbol</th>\n",
       "      <th>variant_nearestCodingGene_symbol</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_bestLocus2GenesOrClosest_id</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>study</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000130940,)</td>\n",
       "      <td>ENSG00000130940</td>\n",
       "      <td>(CASZ1,)</td>\n",
       "      <td>CASZ1</td>\n",
       "      <td>(ENSG00000130940,)</td>\n",
       "      <td>(CASZ1,)</td>\n",
       "      <td>((CASZ1,), 1_10737371_G_GC)</td>\n",
       "      <td>((ENSG00000130940,), 1_10737371_G_GC)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000215910,)</td>\n",
       "      <td>ENSG00000215910</td>\n",
       "      <td>(C1orf167,)</td>\n",
       "      <td>C1orf167</td>\n",
       "      <td>(ENSG00000215910,)</td>\n",
       "      <td>(C1orf167,)</td>\n",
       "      <td>((C1orf167,), 1_11779866_C_T)</td>\n",
       "      <td>((ENSG00000215910,), 1_11779866_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000171303,)</td>\n",
       "      <td>ENSG00000171303</td>\n",
       "      <td>(KCNK3,)</td>\n",
       "      <td>KCNK3</td>\n",
       "      <td>(ENSG00000171303,)</td>\n",
       "      <td>(KCNK3,)</td>\n",
       "      <td>((KCNK3,), 2_26709928_C_T)</td>\n",
       "      <td>((ENSG00000171303,), 2_26709928_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000182263</td>\n",
       "      <td>()</td>\n",
       "      <td>FIGN</td>\n",
       "      <td>(ENSG00000182263,)</td>\n",
       "      <td>(FIGN,)</td>\n",
       "      <td>((FIGN,), 2_164151656_C_G)</td>\n",
       "      <td>((ENSG00000182263,), 2_164151656_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000163491,)</td>\n",
       "      <td>ENSG00000163491</td>\n",
       "      <td>(NEK10,)</td>\n",
       "      <td>NEK10</td>\n",
       "      <td>(ENSG00000163491,)</td>\n",
       "      <td>(NEK10,)</td>\n",
       "      <td>((NEK10,), 3_27322446_T_A)</td>\n",
       "      <td>((ENSG00000163491,), 3_27322446_T_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000033867,)</td>\n",
       "      <td>ENSG00000033867</td>\n",
       "      <td>(SLC4A7,)</td>\n",
       "      <td>SLC4A7</td>\n",
       "      <td>(ENSG00000033867,)</td>\n",
       "      <td>(SLC4A7,)</td>\n",
       "      <td>((SLC4A7,), 3_27521497_C_T)</td>\n",
       "      <td>((ENSG00000033867,), 3_27521497_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000085276,)</td>\n",
       "      <td>ENSG00000085276</td>\n",
       "      <td>(MECOM,)</td>\n",
       "      <td>MECOM</td>\n",
       "      <td>(ENSG00000085276,)</td>\n",
       "      <td>(MECOM,)</td>\n",
       "      <td>((MECOM,), 3_169379112_C_T)</td>\n",
       "      <td>((ENSG00000085276,), 3_169379112_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000138675,)</td>\n",
       "      <td>ENSG00000138675</td>\n",
       "      <td>(FGF5,)</td>\n",
       "      <td>FGF5</td>\n",
       "      <td>(ENSG00000138675,)</td>\n",
       "      <td>(FGF5,)</td>\n",
       "      <td>((FGF5,), 4_80246155_C_T)</td>\n",
       "      <td>((ENSG00000138675,), 4_80246155_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000164116,)</td>\n",
       "      <td>ENSG00000061918</td>\n",
       "      <td>(GUCY1A1,)</td>\n",
       "      <td>GUCY1B1</td>\n",
       "      <td>(ENSG00000164116,)</td>\n",
       "      <td>(GUCY1A1,)</td>\n",
       "      <td>((GUCY1A1,), 4_155724361_C_A)</td>\n",
       "      <td>((ENSG00000164116,), 4_155724361_C_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000113389,)</td>\n",
       "      <td>ENSG00000113389</td>\n",
       "      <td>(NPR3,)</td>\n",
       "      <td>NPR3</td>\n",
       "      <td>(ENSG00000113389,)</td>\n",
       "      <td>(NPR3,)</td>\n",
       "      <td>((NPR3,), 5_32709547_C_T)</td>\n",
       "      <td>((ENSG00000113389,), 5_32709547_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000113282</td>\n",
       "      <td>()</td>\n",
       "      <td>CLINT1</td>\n",
       "      <td>(ENSG00000113282,)</td>\n",
       "      <td>(CLINT1,)</td>\n",
       "      <td>((CLINT1,), 5_158417097_G_A)</td>\n",
       "      <td>((ENSG00000113282,), 5_158417097_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000171467</td>\n",
       "      <td>()</td>\n",
       "      <td>ZNF318</td>\n",
       "      <td>(ENSG00000171467,)</td>\n",
       "      <td>(ZNF318,)</td>\n",
       "      <td>((ZNF318,), 6_43385242_A_G)</td>\n",
       "      <td>((ENSG00000171467,), 6_43385242_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000105851, ENSG00000253276)</td>\n",
       "      <td>ENSG00000105851</td>\n",
       "      <td>(PIK3CG, CCDC71L)</td>\n",
       "      <td>PIK3CG</td>\n",
       "      <td>(ENSG00000105851, ENSG00000253276)</td>\n",
       "      <td>(PIK3CG, CCDC71L)</td>\n",
       "      <td>((PIK3CG, CCDC71L), 7_106776021_G_A)</td>\n",
       "      <td>((ENSG00000105851, ENSG00000253276), 7_1067760...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000164867,)</td>\n",
       "      <td>ENSG00000164867</td>\n",
       "      <td>(NOS3,)</td>\n",
       "      <td>NOS3</td>\n",
       "      <td>(ENSG00000164867,)</td>\n",
       "      <td>(NOS3,)</td>\n",
       "      <td>((NOS3,), 7_150993088_C_T)</td>\n",
       "      <td>((ENSG00000164867,), 7_150993088_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000275342,)</td>\n",
       "      <td>ENSG00000275342</td>\n",
       "      <td>(PRAG1,)</td>\n",
       "      <td>PRAG1</td>\n",
       "      <td>(ENSG00000275342,)</td>\n",
       "      <td>(PRAG1,)</td>\n",
       "      <td>((PRAG1,), 8_8520592_T_C)</td>\n",
       "      <td>((ENSG00000275342,), 8_8520592_T_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000173281,)</td>\n",
       "      <td>ENSG00000173281</td>\n",
       "      <td>(PPP1R3B,)</td>\n",
       "      <td>PPP1R3B</td>\n",
       "      <td>(ENSG00000173281,)</td>\n",
       "      <td>(PPP1R3B,)</td>\n",
       "      <td>((PPP1R3B,), 8_9172877_T_G)</td>\n",
       "      <td>((ENSG00000173281,), 8_9172877_T_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000173281,)</td>\n",
       "      <td>ENSG00000173281</td>\n",
       "      <td>(PPP1R3B,)</td>\n",
       "      <td>PPP1R3B</td>\n",
       "      <td>(ENSG00000173281,)</td>\n",
       "      <td>(PPP1R3B,)</td>\n",
       "      <td>((PPP1R3B,), 8_9293015_C_T)</td>\n",
       "      <td>((ENSG00000173281,), 8_9293015_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000175806</td>\n",
       "      <td>()</td>\n",
       "      <td>MSRA</td>\n",
       "      <td>(ENSG00000175806,)</td>\n",
       "      <td>(MSRA,)</td>\n",
       "      <td>((MSRA,), 8_9822124_A_G)</td>\n",
       "      <td>((ENSG00000175806,), 8_9822124_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000175806,)</td>\n",
       "      <td>ENSG00000175806</td>\n",
       "      <td>(MSRA,)</td>\n",
       "      <td>MSRA</td>\n",
       "      <td>(ENSG00000175806,)</td>\n",
       "      <td>(MSRA,)</td>\n",
       "      <td>((MSRA,), 8_9948185_T_C)</td>\n",
       "      <td>((ENSG00000175806,), 8_9948185_T_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000184647</td>\n",
       "      <td>()</td>\n",
       "      <td>PRSS55</td>\n",
       "      <td>(ENSG00000184647,)</td>\n",
       "      <td>(PRSS55,)</td>\n",
       "      <td>((PRSS55,), 8_10406750_A_G)</td>\n",
       "      <td>((ENSG00000184647,), 8_10406750_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000171060</td>\n",
       "      <td>()</td>\n",
       "      <td>C8orf74</td>\n",
       "      <td>(ENSG00000171060,)</td>\n",
       "      <td>(C8orf74,)</td>\n",
       "      <td>((C8orf74,), 8_10658864_A_G)</td>\n",
       "      <td>((ENSG00000171060,), 8_10658864_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000258724</td>\n",
       "      <td>()</td>\n",
       "      <td>PINX1</td>\n",
       "      <td>(ENSG00000258724,)</td>\n",
       "      <td>(PINX1,)</td>\n",
       "      <td>((PINX1,), 8_10817678_T_C)</td>\n",
       "      <td>((ENSG00000258724,), 8_10817678_T_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000254093</td>\n",
       "      <td>()</td>\n",
       "      <td>PINX1</td>\n",
       "      <td>(ENSG00000254093,)</td>\n",
       "      <td>(PINX1,)</td>\n",
       "      <td>((PINX1,), 8_10962344_C_T)</td>\n",
       "      <td>((ENSG00000254093,), 8_10962344_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000154319,)</td>\n",
       "      <td>ENSG00000177710</td>\n",
       "      <td>(FAM167A,)</td>\n",
       "      <td>SLC35G5</td>\n",
       "      <td>(ENSG00000154319,)</td>\n",
       "      <td>(FAM167A,)</td>\n",
       "      <td>((FAM167A,), 8_11398066_A_C)</td>\n",
       "      <td>((ENSG00000154319,), 8_11398066_A_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000136574,)</td>\n",
       "      <td>ENSG00000136574</td>\n",
       "      <td>(GATA4,)</td>\n",
       "      <td>GATA4</td>\n",
       "      <td>(ENSG00000136574,)</td>\n",
       "      <td>(GATA4,)</td>\n",
       "      <td>((GATA4,), 8_11610048_C_G)</td>\n",
       "      <td>((ENSG00000136574,), 8_11610048_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000154328</td>\n",
       "      <td>()</td>\n",
       "      <td>NEIL2</td>\n",
       "      <td>(ENSG00000154328,)</td>\n",
       "      <td>(NEIL2,)</td>\n",
       "      <td>((NEIL2,), 8_11752486_C_T)</td>\n",
       "      <td>((ENSG00000154328,), 8_11752486_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000165995,)</td>\n",
       "      <td>ENSG00000241058</td>\n",
       "      <td>(CACNB2,)</td>\n",
       "      <td>NSUN6</td>\n",
       "      <td>(ENSG00000165995,)</td>\n",
       "      <td>(CACNB2,)</td>\n",
       "      <td>((CACNB2,), 10_18418519_T_C)</td>\n",
       "      <td>((ENSG00000165995,), 10_18418519_T_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000183346,)</td>\n",
       "      <td>ENSG00000183346</td>\n",
       "      <td>(CABCOCO1,)</td>\n",
       "      <td>CABCOCO1</td>\n",
       "      <td>(ENSG00000183346,)</td>\n",
       "      <td>(CABCOCO1,)</td>\n",
       "      <td>((CABCOCO1,), 10_61758990_G_A)</td>\n",
       "      <td>((ENSG00000183346,), 10_61758990_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000043591,)</td>\n",
       "      <td>ENSG00000043591</td>\n",
       "      <td>(ADRB1,)</td>\n",
       "      <td>ADRB1</td>\n",
       "      <td>(ENSG00000043591,)</td>\n",
       "      <td>(ADRB1,)</td>\n",
       "      <td>((ADRB1,), 10_114032303_G_A)</td>\n",
       "      <td>((ENSG00000043591,), 10_114032303_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000130592,)</td>\n",
       "      <td>ENSG00000130592</td>\n",
       "      <td>(LSP1,)</td>\n",
       "      <td>LSP1</td>\n",
       "      <td>(ENSG00000130592,)</td>\n",
       "      <td>(LSP1,)</td>\n",
       "      <td>((LSP1,), 11_1871355_G_A)</td>\n",
       "      <td>((ENSG00000130592,), 11_1871355_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000214026</td>\n",
       "      <td>()</td>\n",
       "      <td>MRPL23</td>\n",
       "      <td>(ENSG00000214026,)</td>\n",
       "      <td>(MRPL23,)</td>\n",
       "      <td>((MRPL23,), 11_1989738_G_A)</td>\n",
       "      <td>((ENSG00000214026,), 11_1989738_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000110693,)</td>\n",
       "      <td>ENSG00000110696</td>\n",
       "      <td>(SOX6,)</td>\n",
       "      <td>C11orf58</td>\n",
       "      <td>(ENSG00000110693,)</td>\n",
       "      <td>(SOX6,)</td>\n",
       "      <td>((SOX6,), 11_16302860_G_A)</td>\n",
       "      <td>((ENSG00000110693,), 11_16302860_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000166689,)</td>\n",
       "      <td>ENSG00000166689</td>\n",
       "      <td>(PLEKHA7,)</td>\n",
       "      <td>PLEKHA7</td>\n",
       "      <td>(ENSG00000166689,)</td>\n",
       "      <td>(PLEKHA7,)</td>\n",
       "      <td>((PLEKHA7,), 11_16878556_T_G)</td>\n",
       "      <td>((ENSG00000166689,), 11_16878556_T_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000011405,)</td>\n",
       "      <td>ENSG00000011405</td>\n",
       "      <td>(PIK3C2A,)</td>\n",
       "      <td>PIK3C2A</td>\n",
       "      <td>(ENSG00000011405,)</td>\n",
       "      <td>(PIK3C2A,)</td>\n",
       "      <td>((PIK3C2A,), 11_17184972_A_T)</td>\n",
       "      <td>((ENSG00000011405,), 11_17184972_A_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000188211,)</td>\n",
       "      <td>ENSG00000187486</td>\n",
       "      <td>(NCR3LG1,)</td>\n",
       "      <td>KCNJ11</td>\n",
       "      <td>(ENSG00000188211,)</td>\n",
       "      <td>(NCR3LG1,)</td>\n",
       "      <td>((NCR3LG1,), 11_17383292_G_A)</td>\n",
       "      <td>((ENSG00000188211,), 11_17383292_G_A)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000213445,)</td>\n",
       "      <td>ENSG00000213445</td>\n",
       "      <td>(SIPA1,)</td>\n",
       "      <td>SIPA1</td>\n",
       "      <td>(ENSG00000213445,)</td>\n",
       "      <td>(SIPA1,)</td>\n",
       "      <td>((SIPA1,), 11_65638129_G_T)</td>\n",
       "      <td>((ENSG00000213445,), 11_65638129_G_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000165895,)</td>\n",
       "      <td>ENSG00000165895</td>\n",
       "      <td>(ARHGAP42,)</td>\n",
       "      <td>ARHGAP42</td>\n",
       "      <td>(ENSG00000165895,)</td>\n",
       "      <td>(ARHGAP42,)</td>\n",
       "      <td>((ARHGAP42,), 11_100701679_A_G)</td>\n",
       "      <td>((ENSG00000165895,), 11_100701679_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000172789</td>\n",
       "      <td>()</td>\n",
       "      <td>HOXC5</td>\n",
       "      <td>(ENSG00000172789,)</td>\n",
       "      <td>(HOXC5,)</td>\n",
       "      <td>((HOXC5,), 12_54039227_G_C)</td>\n",
       "      <td>((ENSG00000172789,), 12_54039227_G_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000139323,)</td>\n",
       "      <td>ENSG00000257594</td>\n",
       "      <td>(POC1B,)</td>\n",
       "      <td>GALNT4</td>\n",
       "      <td>(ENSG00000139323,)</td>\n",
       "      <td>(POC1B,)</td>\n",
       "      <td>((POC1B,), 12_89445110_C_T)</td>\n",
       "      <td>((ENSG00000139323,), 12_89445110_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000070961,)</td>\n",
       "      <td>ENSG00000070961</td>\n",
       "      <td>(ATP2B1,)</td>\n",
       "      <td>ATP2B1</td>\n",
       "      <td>(ENSG00000070961,)</td>\n",
       "      <td>(ATP2B1,)</td>\n",
       "      <td>((ATP2B1,), 12_89697090_A_G)</td>\n",
       "      <td>((ENSG00000070961,), 12_89697090_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000111252</td>\n",
       "      <td>()</td>\n",
       "      <td>SH2B3</td>\n",
       "      <td>(ENSG00000111252,)</td>\n",
       "      <td>(SH2B3,)</td>\n",
       "      <td>((SH2B3,), 12_111427245_C_G)</td>\n",
       "      <td>((ENSG00000111252,), 12_111427245_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000204842</td>\n",
       "      <td>()</td>\n",
       "      <td>ATXN2</td>\n",
       "      <td>(ENSG00000204842,)</td>\n",
       "      <td>(ATXN2,)</td>\n",
       "      <td>((ATXN2,), 12_111621753_C_T)</td>\n",
       "      <td>((ENSG00000204842,), 12_111621753_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000179295,)</td>\n",
       "      <td>ENSG00000089248</td>\n",
       "      <td>(PTPN11,)</td>\n",
       "      <td>ERP29</td>\n",
       "      <td>(ENSG00000179295,)</td>\n",
       "      <td>(PTPN11,)</td>\n",
       "      <td>((PTPN11,), 12_112049014_A_G)</td>\n",
       "      <td>((ENSG00000179295,), 12_112049014_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000135111,)</td>\n",
       "      <td>ENSG00000135111</td>\n",
       "      <td>(TBX3,)</td>\n",
       "      <td>TBX3</td>\n",
       "      <td>(ENSG00000135111,)</td>\n",
       "      <td>(TBX3,)</td>\n",
       "      <td>((TBX3,), 12_115114632_A_G)</td>\n",
       "      <td>((ENSG00000135111,), 12_115114632_A_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000140506,)</td>\n",
       "      <td>ENSG00000213578</td>\n",
       "      <td>(LMAN1L,)</td>\n",
       "      <td>CPLX3</td>\n",
       "      <td>(ENSG00000140506,)</td>\n",
       "      <td>(LMAN1L,)</td>\n",
       "      <td>((LMAN1L,), 15_74821981_T_C)</td>\n",
       "      <td>((ENSG00000140506,), 15_74821981_T_C)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>()</td>\n",
       "      <td>ENSG00000198794</td>\n",
       "      <td>()</td>\n",
       "      <td>SCAMP5</td>\n",
       "      <td>(ENSG00000198794,)</td>\n",
       "      <td>(SCAMP5,)</td>\n",
       "      <td>((SCAMP5,), 15_74954815_C_G)</td>\n",
       "      <td>((ENSG00000198794,), 15_74954815_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000182511,)</td>\n",
       "      <td>ENSG00000182511</td>\n",
       "      <td>(FES,)</td>\n",
       "      <td>FES</td>\n",
       "      <td>(ENSG00000182511,)</td>\n",
       "      <td>(FES,)</td>\n",
       "      <td>((FES,), 15_90877710_C_G)</td>\n",
       "      <td>((ENSG00000182511,), 15_90877710_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000140718,)</td>\n",
       "      <td>ENSG00000103494</td>\n",
       "      <td>(FTO,)</td>\n",
       "      <td>RPGRIP1L</td>\n",
       "      <td>(ENSG00000140718,)</td>\n",
       "      <td>(FTO,)</td>\n",
       "      <td>((FTO,), 16_53775211_C_T)</td>\n",
       "      <td>((ENSG00000140718,), 16_53775211_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000159640,)</td>\n",
       "      <td>ENSG00000159640</td>\n",
       "      <td>(ACE,)</td>\n",
       "      <td>ACE</td>\n",
       "      <td>(ENSG00000159640,)</td>\n",
       "      <td>(ACE,)</td>\n",
       "      <td>((ACE,), 17_63471557_C_T)</td>\n",
       "      <td>((ENSG00000159640,), 17_63471557_C_T)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000171105,)</td>\n",
       "      <td>ENSG00000171105</td>\n",
       "      <td>(INSR,)</td>\n",
       "      <td>INSR</td>\n",
       "      <td>(ENSG00000171105,)</td>\n",
       "      <td>(INSR,)</td>\n",
       "      <td>((INSR,), 19_7257979_C_G)</td>\n",
       "      <td>((ENSG00000171105,), 19_7257979_C_G)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCST006434_9</th>\n",
       "      <td>(ENSG00000124203,)</td>\n",
       "      <td>ENSG00000124203</td>\n",
       "      <td>(ZNF831,)</td>\n",
       "      <td>ZNF831</td>\n",
       "      <td>(ENSG00000124203,)</td>\n",
       "      <td>(ZNF831,)</td>\n",
       "      <td>((ZNF831,), 20_59175478_C_T)</td>\n",
       "      <td>((ENSG00000124203,), 20_59175478_C_T)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                              bestLocus2Genes_id variant_nearestCodingGene_id  \\\n",
       "study                                                                           \n",
       "GCST006434_9                  (ENSG00000130940,)              ENSG00000130940   \n",
       "GCST006434_9                  (ENSG00000215910,)              ENSG00000215910   \n",
       "GCST006434_9                  (ENSG00000171303,)              ENSG00000171303   \n",
       "GCST006434_9                                  ()              ENSG00000182263   \n",
       "GCST006434_9                  (ENSG00000163491,)              ENSG00000163491   \n",
       "GCST006434_9                  (ENSG00000033867,)              ENSG00000033867   \n",
       "GCST006434_9                  (ENSG00000085276,)              ENSG00000085276   \n",
       "GCST006434_9                  (ENSG00000138675,)              ENSG00000138675   \n",
       "GCST006434_9                  (ENSG00000164116,)              ENSG00000061918   \n",
       "GCST006434_9                  (ENSG00000113389,)              ENSG00000113389   \n",
       "GCST006434_9                                  ()              ENSG00000113282   \n",
       "GCST006434_9                                  ()              ENSG00000171467   \n",
       "GCST006434_9  (ENSG00000105851, ENSG00000253276)              ENSG00000105851   \n",
       "GCST006434_9                  (ENSG00000164867,)              ENSG00000164867   \n",
       "GCST006434_9                  (ENSG00000275342,)              ENSG00000275342   \n",
       "GCST006434_9                  (ENSG00000173281,)              ENSG00000173281   \n",
       "GCST006434_9                  (ENSG00000173281,)              ENSG00000173281   \n",
       "GCST006434_9                                  ()              ENSG00000175806   \n",
       "GCST006434_9                  (ENSG00000175806,)              ENSG00000175806   \n",
       "GCST006434_9                                  ()              ENSG00000184647   \n",
       "GCST006434_9                                  ()              ENSG00000171060   \n",
       "GCST006434_9                                  ()              ENSG00000258724   \n",
       "GCST006434_9                                  ()              ENSG00000254093   \n",
       "GCST006434_9                  (ENSG00000154319,)              ENSG00000177710   \n",
       "GCST006434_9                  (ENSG00000136574,)              ENSG00000136574   \n",
       "GCST006434_9                                  ()              ENSG00000154328   \n",
       "GCST006434_9                  (ENSG00000165995,)              ENSG00000241058   \n",
       "GCST006434_9                  (ENSG00000183346,)              ENSG00000183346   \n",
       "GCST006434_9                  (ENSG00000043591,)              ENSG00000043591   \n",
       "GCST006434_9                  (ENSG00000130592,)              ENSG00000130592   \n",
       "GCST006434_9                                  ()              ENSG00000214026   \n",
       "GCST006434_9                  (ENSG00000110693,)              ENSG00000110696   \n",
       "GCST006434_9                  (ENSG00000166689,)              ENSG00000166689   \n",
       "GCST006434_9                  (ENSG00000011405,)              ENSG00000011405   \n",
       "GCST006434_9                  (ENSG00000188211,)              ENSG00000187486   \n",
       "GCST006434_9                  (ENSG00000213445,)              ENSG00000213445   \n",
       "GCST006434_9                  (ENSG00000165895,)              ENSG00000165895   \n",
       "GCST006434_9                                  ()              ENSG00000172789   \n",
       "GCST006434_9                  (ENSG00000139323,)              ENSG00000257594   \n",
       "GCST006434_9                  (ENSG00000070961,)              ENSG00000070961   \n",
       "GCST006434_9                                  ()              ENSG00000111252   \n",
       "GCST006434_9                                  ()              ENSG00000204842   \n",
       "GCST006434_9                  (ENSG00000179295,)              ENSG00000089248   \n",
       "GCST006434_9                  (ENSG00000135111,)              ENSG00000135111   \n",
       "GCST006434_9                  (ENSG00000140506,)              ENSG00000213578   \n",
       "GCST006434_9                                  ()              ENSG00000198794   \n",
       "GCST006434_9                  (ENSG00000182511,)              ENSG00000182511   \n",
       "GCST006434_9                  (ENSG00000140718,)              ENSG00000103494   \n",
       "GCST006434_9                  (ENSG00000159640,)              ENSG00000159640   \n",
       "GCST006434_9                  (ENSG00000171105,)              ENSG00000171105   \n",
       "GCST006434_9                  (ENSG00000124203,)              ENSG00000124203   \n",
       "\n",
       "             bestLocus2Genes_symbol variant_nearestCodingGene_symbol  \\\n",
       "study                                                                  \n",
       "GCST006434_9               (CASZ1,)                            CASZ1   \n",
       "GCST006434_9            (C1orf167,)                         C1orf167   \n",
       "GCST006434_9               (KCNK3,)                            KCNK3   \n",
       "GCST006434_9                     ()                             FIGN   \n",
       "GCST006434_9               (NEK10,)                            NEK10   \n",
       "GCST006434_9              (SLC4A7,)                           SLC4A7   \n",
       "GCST006434_9               (MECOM,)                            MECOM   \n",
       "GCST006434_9                (FGF5,)                             FGF5   \n",
       "GCST006434_9             (GUCY1A1,)                          GUCY1B1   \n",
       "GCST006434_9                (NPR3,)                             NPR3   \n",
       "GCST006434_9                     ()                           CLINT1   \n",
       "GCST006434_9                     ()                           ZNF318   \n",
       "GCST006434_9      (PIK3CG, CCDC71L)                           PIK3CG   \n",
       "GCST006434_9                (NOS3,)                             NOS3   \n",
       "GCST006434_9               (PRAG1,)                            PRAG1   \n",
       "GCST006434_9             (PPP1R3B,)                          PPP1R3B   \n",
       "GCST006434_9             (PPP1R3B,)                          PPP1R3B   \n",
       "GCST006434_9                     ()                             MSRA   \n",
       "GCST006434_9                (MSRA,)                             MSRA   \n",
       "GCST006434_9                     ()                           PRSS55   \n",
       "GCST006434_9                     ()                          C8orf74   \n",
       "GCST006434_9                     ()                            PINX1   \n",
       "GCST006434_9                     ()                            PINX1   \n",
       "GCST006434_9             (FAM167A,)                          SLC35G5   \n",
       "GCST006434_9               (GATA4,)                            GATA4   \n",
       "GCST006434_9                     ()                            NEIL2   \n",
       "GCST006434_9              (CACNB2,)                            NSUN6   \n",
       "GCST006434_9            (CABCOCO1,)                         CABCOCO1   \n",
       "GCST006434_9               (ADRB1,)                            ADRB1   \n",
       "GCST006434_9                (LSP1,)                             LSP1   \n",
       "GCST006434_9                     ()                           MRPL23   \n",
       "GCST006434_9                (SOX6,)                         C11orf58   \n",
       "GCST006434_9             (PLEKHA7,)                          PLEKHA7   \n",
       "GCST006434_9             (PIK3C2A,)                          PIK3C2A   \n",
       "GCST006434_9             (NCR3LG1,)                           KCNJ11   \n",
       "GCST006434_9               (SIPA1,)                            SIPA1   \n",
       "GCST006434_9            (ARHGAP42,)                         ARHGAP42   \n",
       "GCST006434_9                     ()                            HOXC5   \n",
       "GCST006434_9               (POC1B,)                           GALNT4   \n",
       "GCST006434_9              (ATP2B1,)                           ATP2B1   \n",
       "GCST006434_9                     ()                            SH2B3   \n",
       "GCST006434_9                     ()                            ATXN2   \n",
       "GCST006434_9              (PTPN11,)                            ERP29   \n",
       "GCST006434_9                (TBX3,)                             TBX3   \n",
       "GCST006434_9              (LMAN1L,)                            CPLX3   \n",
       "GCST006434_9                     ()                           SCAMP5   \n",
       "GCST006434_9                 (FES,)                              FES   \n",
       "GCST006434_9                 (FTO,)                         RPGRIP1L   \n",
       "GCST006434_9                 (ACE,)                              ACE   \n",
       "GCST006434_9                (INSR,)                             INSR   \n",
       "GCST006434_9              (ZNF831,)                           ZNF831   \n",
       "\n",
       "                     bestLocus2GenesOrClosest_id  \\\n",
       "study                                              \n",
       "GCST006434_9                  (ENSG00000130940,)   \n",
       "GCST006434_9                  (ENSG00000215910,)   \n",
       "GCST006434_9                  (ENSG00000171303,)   \n",
       "GCST006434_9                  (ENSG00000182263,)   \n",
       "GCST006434_9                  (ENSG00000163491,)   \n",
       "GCST006434_9                  (ENSG00000033867,)   \n",
       "GCST006434_9                  (ENSG00000085276,)   \n",
       "GCST006434_9                  (ENSG00000138675,)   \n",
       "GCST006434_9                  (ENSG00000164116,)   \n",
       "GCST006434_9                  (ENSG00000113389,)   \n",
       "GCST006434_9                  (ENSG00000113282,)   \n",
       "GCST006434_9                  (ENSG00000171467,)   \n",
       "GCST006434_9  (ENSG00000105851, ENSG00000253276)   \n",
       "GCST006434_9                  (ENSG00000164867,)   \n",
       "GCST006434_9                  (ENSG00000275342,)   \n",
       "GCST006434_9                  (ENSG00000173281,)   \n",
       "GCST006434_9                  (ENSG00000173281,)   \n",
       "GCST006434_9                  (ENSG00000175806,)   \n",
       "GCST006434_9                  (ENSG00000175806,)   \n",
       "GCST006434_9                  (ENSG00000184647,)   \n",
       "GCST006434_9                  (ENSG00000171060,)   \n",
       "GCST006434_9                  (ENSG00000258724,)   \n",
       "GCST006434_9                  (ENSG00000254093,)   \n",
       "GCST006434_9                  (ENSG00000154319,)   \n",
       "GCST006434_9                  (ENSG00000136574,)   \n",
       "GCST006434_9                  (ENSG00000154328,)   \n",
       "GCST006434_9                  (ENSG00000165995,)   \n",
       "GCST006434_9                  (ENSG00000183346,)   \n",
       "GCST006434_9                  (ENSG00000043591,)   \n",
       "GCST006434_9                  (ENSG00000130592,)   \n",
       "GCST006434_9                  (ENSG00000214026,)   \n",
       "GCST006434_9                  (ENSG00000110693,)   \n",
       "GCST006434_9                  (ENSG00000166689,)   \n",
       "GCST006434_9                  (ENSG00000011405,)   \n",
       "GCST006434_9                  (ENSG00000188211,)   \n",
       "GCST006434_9                  (ENSG00000213445,)   \n",
       "GCST006434_9                  (ENSG00000165895,)   \n",
       "GCST006434_9                  (ENSG00000172789,)   \n",
       "GCST006434_9                  (ENSG00000139323,)   \n",
       "GCST006434_9                  (ENSG00000070961,)   \n",
       "GCST006434_9                  (ENSG00000111252,)   \n",
       "GCST006434_9                  (ENSG00000204842,)   \n",
       "GCST006434_9                  (ENSG00000179295,)   \n",
       "GCST006434_9                  (ENSG00000135111,)   \n",
       "GCST006434_9                  (ENSG00000140506,)   \n",
       "GCST006434_9                  (ENSG00000198794,)   \n",
       "GCST006434_9                  (ENSG00000182511,)   \n",
       "GCST006434_9                  (ENSG00000140718,)   \n",
       "GCST006434_9                  (ENSG00000159640,)   \n",
       "GCST006434_9                  (ENSG00000171105,)   \n",
       "GCST006434_9                  (ENSG00000124203,)   \n",
       "\n",
       "             bestLocus2GenesOrClosest_symbol  \\\n",
       "study                                          \n",
       "GCST006434_9                        (CASZ1,)   \n",
       "GCST006434_9                     (C1orf167,)   \n",
       "GCST006434_9                        (KCNK3,)   \n",
       "GCST006434_9                         (FIGN,)   \n",
       "GCST006434_9                        (NEK10,)   \n",
       "GCST006434_9                       (SLC4A7,)   \n",
       "GCST006434_9                        (MECOM,)   \n",
       "GCST006434_9                         (FGF5,)   \n",
       "GCST006434_9                      (GUCY1A1,)   \n",
       "GCST006434_9                         (NPR3,)   \n",
       "GCST006434_9                       (CLINT1,)   \n",
       "GCST006434_9                       (ZNF318,)   \n",
       "GCST006434_9               (PIK3CG, CCDC71L)   \n",
       "GCST006434_9                         (NOS3,)   \n",
       "GCST006434_9                        (PRAG1,)   \n",
       "GCST006434_9                      (PPP1R3B,)   \n",
       "GCST006434_9                      (PPP1R3B,)   \n",
       "GCST006434_9                         (MSRA,)   \n",
       "GCST006434_9                         (MSRA,)   \n",
       "GCST006434_9                       (PRSS55,)   \n",
       "GCST006434_9                      (C8orf74,)   \n",
       "GCST006434_9                        (PINX1,)   \n",
       "GCST006434_9                        (PINX1,)   \n",
       "GCST006434_9                      (FAM167A,)   \n",
       "GCST006434_9                        (GATA4,)   \n",
       "GCST006434_9                        (NEIL2,)   \n",
       "GCST006434_9                       (CACNB2,)   \n",
       "GCST006434_9                     (CABCOCO1,)   \n",
       "GCST006434_9                        (ADRB1,)   \n",
       "GCST006434_9                         (LSP1,)   \n",
       "GCST006434_9                       (MRPL23,)   \n",
       "GCST006434_9                         (SOX6,)   \n",
       "GCST006434_9                      (PLEKHA7,)   \n",
       "GCST006434_9                      (PIK3C2A,)   \n",
       "GCST006434_9                      (NCR3LG1,)   \n",
       "GCST006434_9                        (SIPA1,)   \n",
       "GCST006434_9                     (ARHGAP42,)   \n",
       "GCST006434_9                        (HOXC5,)   \n",
       "GCST006434_9                        (POC1B,)   \n",
       "GCST006434_9                       (ATP2B1,)   \n",
       "GCST006434_9                        (SH2B3,)   \n",
       "GCST006434_9                        (ATXN2,)   \n",
       "GCST006434_9                       (PTPN11,)   \n",
       "GCST006434_9                         (TBX3,)   \n",
       "GCST006434_9                       (LMAN1L,)   \n",
       "GCST006434_9                       (SCAMP5,)   \n",
       "GCST006434_9                          (FES,)   \n",
       "GCST006434_9                          (FTO,)   \n",
       "GCST006434_9                          (ACE,)   \n",
       "GCST006434_9                         (INSR,)   \n",
       "GCST006434_9                       (ZNF831,)   \n",
       "\n",
       "             variant_bestLocus2GenesOrClosest_symbol  \\\n",
       "study                                                  \n",
       "GCST006434_9             ((CASZ1,), 1_10737371_G_GC)   \n",
       "GCST006434_9           ((C1orf167,), 1_11779866_C_T)   \n",
       "GCST006434_9              ((KCNK3,), 2_26709928_C_T)   \n",
       "GCST006434_9              ((FIGN,), 2_164151656_C_G)   \n",
       "GCST006434_9              ((NEK10,), 3_27322446_T_A)   \n",
       "GCST006434_9             ((SLC4A7,), 3_27521497_C_T)   \n",
       "GCST006434_9             ((MECOM,), 3_169379112_C_T)   \n",
       "GCST006434_9               ((FGF5,), 4_80246155_C_T)   \n",
       "GCST006434_9           ((GUCY1A1,), 4_155724361_C_A)   \n",
       "GCST006434_9               ((NPR3,), 5_32709547_C_T)   \n",
       "GCST006434_9            ((CLINT1,), 5_158417097_G_A)   \n",
       "GCST006434_9             ((ZNF318,), 6_43385242_A_G)   \n",
       "GCST006434_9    ((PIK3CG, CCDC71L), 7_106776021_G_A)   \n",
       "GCST006434_9              ((NOS3,), 7_150993088_C_T)   \n",
       "GCST006434_9               ((PRAG1,), 8_8520592_T_C)   \n",
       "GCST006434_9             ((PPP1R3B,), 8_9172877_T_G)   \n",
       "GCST006434_9             ((PPP1R3B,), 8_9293015_C_T)   \n",
       "GCST006434_9                ((MSRA,), 8_9822124_A_G)   \n",
       "GCST006434_9                ((MSRA,), 8_9948185_T_C)   \n",
       "GCST006434_9             ((PRSS55,), 8_10406750_A_G)   \n",
       "GCST006434_9            ((C8orf74,), 8_10658864_A_G)   \n",
       "GCST006434_9              ((PINX1,), 8_10817678_T_C)   \n",
       "GCST006434_9              ((PINX1,), 8_10962344_C_T)   \n",
       "GCST006434_9            ((FAM167A,), 8_11398066_A_C)   \n",
       "GCST006434_9              ((GATA4,), 8_11610048_C_G)   \n",
       "GCST006434_9              ((NEIL2,), 8_11752486_C_T)   \n",
       "GCST006434_9            ((CACNB2,), 10_18418519_T_C)   \n",
       "GCST006434_9          ((CABCOCO1,), 10_61758990_G_A)   \n",
       "GCST006434_9            ((ADRB1,), 10_114032303_G_A)   \n",
       "GCST006434_9               ((LSP1,), 11_1871355_G_A)   \n",
       "GCST006434_9             ((MRPL23,), 11_1989738_G_A)   \n",
       "GCST006434_9              ((SOX6,), 11_16302860_G_A)   \n",
       "GCST006434_9           ((PLEKHA7,), 11_16878556_T_G)   \n",
       "GCST006434_9           ((PIK3C2A,), 11_17184972_A_T)   \n",
       "GCST006434_9           ((NCR3LG1,), 11_17383292_G_A)   \n",
       "GCST006434_9             ((SIPA1,), 11_65638129_G_T)   \n",
       "GCST006434_9         ((ARHGAP42,), 11_100701679_A_G)   \n",
       "GCST006434_9             ((HOXC5,), 12_54039227_G_C)   \n",
       "GCST006434_9             ((POC1B,), 12_89445110_C_T)   \n",
       "GCST006434_9            ((ATP2B1,), 12_89697090_A_G)   \n",
       "GCST006434_9            ((SH2B3,), 12_111427245_C_G)   \n",
       "GCST006434_9            ((ATXN2,), 12_111621753_C_T)   \n",
       "GCST006434_9           ((PTPN11,), 12_112049014_A_G)   \n",
       "GCST006434_9             ((TBX3,), 12_115114632_A_G)   \n",
       "GCST006434_9            ((LMAN1L,), 15_74821981_T_C)   \n",
       "GCST006434_9            ((SCAMP5,), 15_74954815_C_G)   \n",
       "GCST006434_9               ((FES,), 15_90877710_C_G)   \n",
       "GCST006434_9               ((FTO,), 16_53775211_C_T)   \n",
       "GCST006434_9               ((ACE,), 17_63471557_C_T)   \n",
       "GCST006434_9               ((INSR,), 19_7257979_C_G)   \n",
       "GCST006434_9            ((ZNF831,), 20_59175478_C_T)   \n",
       "\n",
       "                            variant_bestLocus2GenesOrClosest_id  \n",
       "study                                                            \n",
       "GCST006434_9              ((ENSG00000130940,), 1_10737371_G_GC)  \n",
       "GCST006434_9               ((ENSG00000215910,), 1_11779866_C_T)  \n",
       "GCST006434_9               ((ENSG00000171303,), 2_26709928_C_T)  \n",
       "GCST006434_9              ((ENSG00000182263,), 2_164151656_C_G)  \n",
       "GCST006434_9               ((ENSG00000163491,), 3_27322446_T_A)  \n",
       "GCST006434_9               ((ENSG00000033867,), 3_27521497_C_T)  \n",
       "GCST006434_9              ((ENSG00000085276,), 3_169379112_C_T)  \n",
       "GCST006434_9               ((ENSG00000138675,), 4_80246155_C_T)  \n",
       "GCST006434_9              ((ENSG00000164116,), 4_155724361_C_A)  \n",
       "GCST006434_9               ((ENSG00000113389,), 5_32709547_C_T)  \n",
       "GCST006434_9              ((ENSG00000113282,), 5_158417097_G_A)  \n",
       "GCST006434_9               ((ENSG00000171467,), 6_43385242_A_G)  \n",
       "GCST006434_9  ((ENSG00000105851, ENSG00000253276), 7_1067760...  \n",
       "GCST006434_9              ((ENSG00000164867,), 7_150993088_C_T)  \n",
       "GCST006434_9                ((ENSG00000275342,), 8_8520592_T_C)  \n",
       "GCST006434_9                ((ENSG00000173281,), 8_9172877_T_G)  \n",
       "GCST006434_9                ((ENSG00000173281,), 8_9293015_C_T)  \n",
       "GCST006434_9                ((ENSG00000175806,), 8_9822124_A_G)  \n",
       "GCST006434_9                ((ENSG00000175806,), 8_9948185_T_C)  \n",
       "GCST006434_9               ((ENSG00000184647,), 8_10406750_A_G)  \n",
       "GCST006434_9               ((ENSG00000171060,), 8_10658864_A_G)  \n",
       "GCST006434_9               ((ENSG00000258724,), 8_10817678_T_C)  \n",
       "GCST006434_9               ((ENSG00000254093,), 8_10962344_C_T)  \n",
       "GCST006434_9               ((ENSG00000154319,), 8_11398066_A_C)  \n",
       "GCST006434_9               ((ENSG00000136574,), 8_11610048_C_G)  \n",
       "GCST006434_9               ((ENSG00000154328,), 8_11752486_C_T)  \n",
       "GCST006434_9              ((ENSG00000165995,), 10_18418519_T_C)  \n",
       "GCST006434_9              ((ENSG00000183346,), 10_61758990_G_A)  \n",
       "GCST006434_9             ((ENSG00000043591,), 10_114032303_G_A)  \n",
       "GCST006434_9               ((ENSG00000130592,), 11_1871355_G_A)  \n",
       "GCST006434_9               ((ENSG00000214026,), 11_1989738_G_A)  \n",
       "GCST006434_9              ((ENSG00000110693,), 11_16302860_G_A)  \n",
       "GCST006434_9              ((ENSG00000166689,), 11_16878556_T_G)  \n",
       "GCST006434_9              ((ENSG00000011405,), 11_17184972_A_T)  \n",
       "GCST006434_9              ((ENSG00000188211,), 11_17383292_G_A)  \n",
       "GCST006434_9              ((ENSG00000213445,), 11_65638129_G_T)  \n",
       "GCST006434_9             ((ENSG00000165895,), 11_100701679_A_G)  \n",
       "GCST006434_9              ((ENSG00000172789,), 12_54039227_G_C)  \n",
       "GCST006434_9              ((ENSG00000139323,), 12_89445110_C_T)  \n",
       "GCST006434_9              ((ENSG00000070961,), 12_89697090_A_G)  \n",
       "GCST006434_9             ((ENSG00000111252,), 12_111427245_C_G)  \n",
       "GCST006434_9             ((ENSG00000204842,), 12_111621753_C_T)  \n",
       "GCST006434_9             ((ENSG00000179295,), 12_112049014_A_G)  \n",
       "GCST006434_9             ((ENSG00000135111,), 12_115114632_A_G)  \n",
       "GCST006434_9              ((ENSG00000140506,), 15_74821981_T_C)  \n",
       "GCST006434_9              ((ENSG00000198794,), 15_74954815_C_G)  \n",
       "GCST006434_9              ((ENSG00000182511,), 15_90877710_C_G)  \n",
       "GCST006434_9              ((ENSG00000140718,), 16_53775211_C_T)  \n",
       "GCST006434_9              ((ENSG00000159640,), 17_63471557_C_T)  \n",
       "GCST006434_9               ((ENSG00000171105,), 19_7257979_C_G)  \n",
       "GCST006434_9              ((ENSG00000124203,), 20_59175478_C_T)  "
      ]
     },
     "execution_count": 92,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bestgenes_df.loc['GCST006434_9'][[\n",
    "    'bestLocus2Genes_id', \n",
    "    'variant_nearestCodingGene_id', \n",
    "    'bestLocus2Genes_symbol',\n",
    "    'variant_nearestCodingGene_symbol', \n",
    "    'bestLocus2GenesOrClosest_id', \n",
    "    'bestLocus2GenesOrClosest_symbol', \n",
    "    'variant_bestLocus2GenesOrClosest_symbol',\n",
    "    'variant_bestLocus2GenesOrClosest_id',\n",
    "]]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Save objects"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 93,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 93,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "'nan' in info_df[~info_df.bestLocus2GenesOrClosest_id.isnull()].explode('bestLocus2GenesOrClosest_id').bestLocus2GenesOrClosest_id.unique()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 94,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>traitReported</th>\n",
       "      <th>source</th>\n",
       "      <th>traitEfos</th>\n",
       "      <th>pmid</th>\n",
       "      <th>pubDate</th>\n",
       "      <th>pubJournal</th>\n",
       "      <th>pubTitle</th>\n",
       "      <th>pubAuthor</th>\n",
       "      <th>hasSumstats</th>\n",
       "      <th>ancestryInitial</th>\n",
       "      <th>ancestryReplication</th>\n",
       "      <th>nInitial</th>\n",
       "      <th>nReplication</th>\n",
       "      <th>nCases</th>\n",
       "      <th>traitCategory</th>\n",
       "      <th>numAssocLoci</th>\n",
       "      <th>nTotal</th>\n",
       "      <th>bestLocus2GenesOrClosest_id</th>\n",
       "      <th>bestLocus2GenesOrClosest_symbol</th>\n",
       "      <th>variant_gene_id_pairs</th>\n",
       "      <th>variant_gene_symbol_pairs</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>studyId</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_BACTINF_NOS</th>\n",
       "      <td>Bacterial infection, other or unspecified</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0000771]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218637]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218637</td>\n",
       "      <td>0</td>\n",
       "      <td>20977</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>2</td>\n",
       "      <td>218637</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_DERMATOPHYTOSIS</th>\n",
       "      <td>Dermatophytosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0004678]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=216472]</td>\n",
       "      <td>[]</td>\n",
       "      <td>216472</td>\n",
       "      <td>0</td>\n",
       "      <td>1656</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>216472</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_EBV</th>\n",
       "      <td>Infectious mononucleosis</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_0007326]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=214904]</td>\n",
       "      <td>[]</td>\n",
       "      <td>214904</td>\n",
       "      <td>0</td>\n",
       "      <td>1238</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>214904</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GASTROENTERITIS_NOS</th>\n",
       "      <td>Diarrhoea and gastroenteritis of presumed infe...</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[MONDO_0045031]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=212553]</td>\n",
       "      <td>[]</td>\n",
       "      <td>212553</td>\n",
       "      <td>0</td>\n",
       "      <td>15255</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>212553</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FINNGEN_R5_AB1_GHLAMY_OTHER</th>\n",
       "      <td>Other diseases caused by chlamydiae</td>\n",
       "      <td>FINNGEN</td>\n",
       "      <td>[EFO_1001288]</td>\n",
       "      <td>None</td>\n",
       "      <td>2021-05-11</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>FINNGEN_R5</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=218772]</td>\n",
       "      <td>[]</td>\n",
       "      <td>218772</td>\n",
       "      <td>0</td>\n",
       "      <td>167</td>\n",
       "      <td>infectious disease</td>\n",
       "      <td>1</td>\n",
       "      <td>218772</td>\n",
       "      <td>(ENSG00000112818, ENSG00000069122)</td>\n",
       "      <td>(MEP1A, ADGRF5)</td>\n",
       "      <td>(((ENSG00000112818, ENSG00000069122), 6_468771...</td>\n",
       "      <td>(((MEP1A, ADGRF5), 6_46877116_T_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_960_2</th>\n",
       "      <td>Allergy/adverse effect of penicillin</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=397887]</td>\n",
       "      <td>[]</td>\n",
       "      <td>397887</td>\n",
       "      <td>0</td>\n",
       "      <td>16090</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>397887</td>\n",
       "      <td>(ENSG00000188981,)</td>\n",
       "      <td>(MSANTD1,)</td>\n",
       "      <td>(((ENSG00000188981,), 4_3240118_C_T),)</td>\n",
       "      <td>(((MSANTD1,), 4_3240118_C_T),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965</th>\n",
       "      <td>Poisoning by analgesics, antipyretics, and ant...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=388707]</td>\n",
       "      <td>[]</td>\n",
       "      <td>388707</td>\n",
       "      <td>0</td>\n",
       "      <td>6910</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>388707</td>\n",
       "      <td>(ENSG00000145839,)</td>\n",
       "      <td>(IL9,)</td>\n",
       "      <td>(((ENSG00000145839,), 5_135834716_T_G),)</td>\n",
       "      <td>(((IL9,), 5_135834716_T_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_965_1</th>\n",
       "      <td>Opiates and related narcotics causing adverse ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382947]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382947</td>\n",
       "      <td>0</td>\n",
       "      <td>1150</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382947</td>\n",
       "      <td>(ENSG00000152495,)</td>\n",
       "      <td>(CAMK4,)</td>\n",
       "      <td>(((ENSG00000152495,), 5_111211885_A_G),)</td>\n",
       "      <td>(((CAMK4,), 5_111211885_A_G),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_967</th>\n",
       "      <td>Adverse effects of sedatives or other central ...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0009658]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=382385]</td>\n",
       "      <td>[]</td>\n",
       "      <td>382385</td>\n",
       "      <td>0</td>\n",
       "      <td>588</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>382385</td>\n",
       "      <td>(ENSG00000101574,)</td>\n",
       "      <td>(METTL4,)</td>\n",
       "      <td>(((ENSG00000101574,), 18_1777012_G_A),)</td>\n",
       "      <td>(((METTL4,), 18_1777012_G_A),)</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAIGE_971</th>\n",
       "      <td>Poisoning by drugs primarily affecting the aut...</td>\n",
       "      <td>SAIGE</td>\n",
       "      <td>[EFO_0008546]</td>\n",
       "      <td>None</td>\n",
       "      <td>2018-10-24</td>\n",
       "      <td>None</td>\n",
       "      <td>None</td>\n",
       "      <td>UKB SAIGE</td>\n",
       "      <td>True</td>\n",
       "      <td>[European=381988]</td>\n",
       "      <td>[]</td>\n",
       "      <td>381988</td>\n",
       "      <td>0</td>\n",
       "      <td>191</td>\n",
       "      <td>injury, poisoning or other complication</td>\n",
       "      <td>1</td>\n",
       "      <td>381988</td>\n",
       "      <td>(ENSG00000172361,)</td>\n",
       "      <td>(CFAP53,)</td>\n",
       "      <td>(((ENSG00000172361,), 18_50238751_G_C),)</td>\n",
       "      <td>(((CFAP53,), 18_50238751_G_C),)</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>17054 rows × 21 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                                                        traitReported  \\\n",
       "studyId                                                                                 \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                  Bacterial infection, other or unspecified   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                        Dermatophytosis   \n",
       "FINNGEN_R5_AB1_EBV                                           Infectious mononucleosis   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  Diarrhoea and gastroenteritis of presumed infe...   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                       Other diseases caused by chlamydiae   \n",
       "...                                                                               ...   \n",
       "SAIGE_960_2                                      Allergy/adverse effect of penicillin   \n",
       "SAIGE_965                           Poisoning by analgesics, antipyretics, and ant...   \n",
       "SAIGE_965_1                         Opiates and related narcotics causing adverse ...   \n",
       "SAIGE_967                           Adverse effects of sedatives or other central ...   \n",
       "SAIGE_971                           Poisoning by drugs primarily affecting the aut...   \n",
       "\n",
       "                                     source        traitEfos  pmid  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN    [EFO_0000771]  None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN  [MONDO_0004678]  None   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN    [EFO_0007326]  None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN  [MONDO_0045031]  None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN    [EFO_1001288]  None   \n",
       "...                                     ...              ...   ...   \n",
       "SAIGE_960_2                           SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965                             SAIGE    [EFO_0008546]  None   \n",
       "SAIGE_965_1                           SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_967                             SAIGE    [EFO_0009658]  None   \n",
       "SAIGE_971                             SAIGE    [EFO_0008546]  None   \n",
       "\n",
       "                                       pubDate pubJournal pubTitle  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_EBV                  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  2021-05-11       None     None   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         2021-05-11       None     None   \n",
       "...                                        ...        ...      ...   \n",
       "SAIGE_960_2                         2018-10-24       None     None   \n",
       "SAIGE_965                           2018-10-24       None     None   \n",
       "SAIGE_965_1                         2018-10-24       None     None   \n",
       "SAIGE_967                           2018-10-24       None     None   \n",
       "SAIGE_971                           2018-10-24       None     None   \n",
       "\n",
       "                                     pubAuthor  hasSumstats  \\\n",
       "studyId                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_EBV                  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  FINNGEN_R5         True   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         FINNGEN_R5         True   \n",
       "...                                        ...          ...   \n",
       "SAIGE_960_2                          UKB SAIGE         True   \n",
       "SAIGE_965                            UKB SAIGE         True   \n",
       "SAIGE_965_1                          UKB SAIGE         True   \n",
       "SAIGE_967                            UKB SAIGE         True   \n",
       "SAIGE_971                            UKB SAIGE         True   \n",
       "\n",
       "                                      ancestryInitial ancestryReplication  \\\n",
       "studyId                                                                     \n",
       "FINNGEN_R5_AB1_BACTINF_NOS          [European=218637]                  []   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS      [European=216472]                  []   \n",
       "FINNGEN_R5_AB1_EBV                  [European=214904]                  []   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS  [European=212553]                  []   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         [European=218772]                  []   \n",
       "...                                               ...                 ...   \n",
       "SAIGE_960_2                         [European=397887]                  []   \n",
       "SAIGE_965                           [European=388707]                  []   \n",
       "SAIGE_965_1                         [European=382947]                  []   \n",
       "SAIGE_967                           [European=382385]                  []   \n",
       "SAIGE_971                           [European=381988]                  []   \n",
       "\n",
       "                                    nInitial nReplication nCases  \\\n",
       "studyId                                                            \n",
       "FINNGEN_R5_AB1_BACTINF_NOS            218637            0  20977   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS        216472            0   1656   \n",
       "FINNGEN_R5_AB1_EBV                    214904            0   1238   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS    212553            0  15255   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER           218772            0    167   \n",
       "...                                      ...          ...    ...   \n",
       "SAIGE_960_2                           397887            0  16090   \n",
       "SAIGE_965                             388707            0   6910   \n",
       "SAIGE_965_1                           382947            0   1150   \n",
       "SAIGE_967                             382385            0    588   \n",
       "SAIGE_971                             381988            0    191   \n",
       "\n",
       "                                                              traitCategory  \\\n",
       "studyId                                                                       \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                               infectious disease   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                           infectious disease   \n",
       "FINNGEN_R5_AB1_EBV                                       infectious disease   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                       infectious disease   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                              infectious disease   \n",
       "...                                                                     ...   \n",
       "SAIGE_960_2                         injury, poisoning or other complication   \n",
       "SAIGE_965                           injury, poisoning or other complication   \n",
       "SAIGE_965_1                         injury, poisoning or other complication   \n",
       "SAIGE_967                           injury, poisoning or other complication   \n",
       "SAIGE_971                           injury, poisoning or other complication   \n",
       "\n",
       "                                    numAssocLoci  nTotal  \\\n",
       "studyId                                                    \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                     2  218637   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                 1  216472   \n",
       "FINNGEN_R5_AB1_EBV                             1  214904   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS             1  212553   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                    1  218772   \n",
       "...                                          ...     ...   \n",
       "SAIGE_960_2                                    1  397887   \n",
       "SAIGE_965                                      1  388707   \n",
       "SAIGE_965_1                                    1  382947   \n",
       "SAIGE_967                                      1  382385   \n",
       "SAIGE_971                                      1  381988   \n",
       "\n",
       "                                           bestLocus2GenesOrClosest_id  \\\n",
       "studyId                                                                  \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                         NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                     NaN   \n",
       "FINNGEN_R5_AB1_EBV                                                 NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                 NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (ENSG00000112818, ENSG00000069122)   \n",
       "...                                                                ...   \n",
       "SAIGE_960_2                                         (ENSG00000188981,)   \n",
       "SAIGE_965                                           (ENSG00000145839,)   \n",
       "SAIGE_965_1                                         (ENSG00000152495,)   \n",
       "SAIGE_967                                           (ENSG00000101574,)   \n",
       "SAIGE_971                                           (ENSG00000172361,)   \n",
       "\n",
       "                                   bestLocus2GenesOrClosest_symbol  \\\n",
       "studyId                                                              \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                     NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                 NaN   \n",
       "FINNGEN_R5_AB1_EBV                                             NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                             NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER                        (MEP1A, ADGRF5)   \n",
       "...                                                            ...   \n",
       "SAIGE_960_2                                             (MSANTD1,)   \n",
       "SAIGE_965                                                   (IL9,)   \n",
       "SAIGE_965_1                                               (CAMK4,)   \n",
       "SAIGE_967                                                (METTL4,)   \n",
       "SAIGE_971                                                (CFAP53,)   \n",
       "\n",
       "                                                                variant_gene_id_pairs  \\\n",
       "studyId                                                                                 \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                                        NaN   \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                                    NaN   \n",
       "FINNGEN_R5_AB1_EBV                                                                NaN   \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                                NaN   \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (((ENSG00000112818, ENSG00000069122), 6_468771...   \n",
       "...                                                                               ...   \n",
       "SAIGE_960_2                                    (((ENSG00000188981,), 4_3240118_C_T),)   \n",
       "SAIGE_965                                    (((ENSG00000145839,), 5_135834716_T_G),)   \n",
       "SAIGE_965_1                                  (((ENSG00000152495,), 5_111211885_A_G),)   \n",
       "SAIGE_967                                     (((ENSG00000101574,), 18_1777012_G_A),)   \n",
       "SAIGE_971                                    (((ENSG00000172361,), 18_50238751_G_C),)   \n",
       "\n",
       "                                               variant_gene_symbol_pairs  \n",
       "studyId                                                                   \n",
       "FINNGEN_R5_AB1_BACTINF_NOS                                           NaN  \n",
       "FINNGEN_R5_AB1_DERMATOPHYTOSIS                                       NaN  \n",
       "FINNGEN_R5_AB1_EBV                                                   NaN  \n",
       "FINNGEN_R5_AB1_GASTROENTERITIS_NOS                                   NaN  \n",
       "FINNGEN_R5_AB1_GHLAMY_OTHER         (((MEP1A, ADGRF5), 6_46877116_T_G),)  \n",
       "...                                                                  ...  \n",
       "SAIGE_960_2                               (((MSANTD1,), 4_3240118_C_T),)  \n",
       "SAIGE_965                                   (((IL9,), 5_135834716_T_G),)  \n",
       "SAIGE_965_1                               (((CAMK4,), 5_111211885_A_G),)  \n",
       "SAIGE_967                                 (((METTL4,), 18_1777012_G_A),)  \n",
       "SAIGE_971                                (((CFAP53,), 18_50238751_G_C),)  \n",
       "\n",
       "[17054 rows x 21 columns]"
      ]
     },
     "execution_count": 94,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "info_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 95,
   "metadata": {},
   "outputs": [],
   "source": [
    "info_df.to_pickle('data/info.pkl')\n",
    "bestgenes_df.to_pickle('data/bestgenes.pkl')"
   ]
  }
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