diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index ab51b831..f4024fc7 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -13,6 +13,7 @@ and this project adheres to `Semantic Versioning <https://semver.org/spec/v2.0.0
 Changed
 -------
 * In bleak.backends.winrt.util the SetTimer, KillTimer and CoGetApartmentType functions define their own prototype and don't change ctypes' global state anymore
+* Improved performance of BlueZ backend when there are many adapters.
 
 `0.22.2`_ (2024-06-01)
 ======================
diff --git a/bleak/backends/bluezdbus/manager.py b/bleak/backends/bluezdbus/manager.py
index 1d5d16b5..a784f512 100644
--- a/bleak/backends/bluezdbus/manager.py
+++ b/bleak/backends/bluezdbus/manager.py
@@ -10,12 +10,12 @@
 import contextlib
 import logging
 import os
+from collections import defaultdict
 from typing import (
     Any,
     Callable,
     Coroutine,
     Dict,
-    Iterable,
     List,
     MutableMapping,
     NamedTuple,
@@ -55,22 +55,6 @@
 """
 
 
-class CallbackAndState(NamedTuple):
-    """
-    Encapsulates an :data:`AdvertisementCallback` and some state.
-    """
-
-    callback: AdvertisementCallback
-    """
-    The callback.
-    """
-
-    adapter_path: str
-    """
-    The D-Bus object path of the adapter associated with the callback.
-    """
-
-
 DevicePropertiesChangedCallback = Callable[[Optional[Any]], None]
 """
 A callback that is called when the properties of a device change in BlueZ.
@@ -194,7 +178,9 @@ def __init__(self):
         # map of characteristic d-bus object paths to set of descriptor d-bus object paths
         self._descriptor_map: Dict[str, Set[str]] = {}
 
-        self._advertisement_callbacks: List[CallbackAndState] = []
+        self._advertisement_callbacks: defaultdict[str, List[AdvertisementCallback]] = (
+            defaultdict(list)
+        )
         self._device_removed_callbacks: List[DeviceRemovedCallbackAndState] = []
         self._device_watchers: Dict[str, Set[DeviceWatcher]] = {}
         self._condition_callbacks: Dict[str, Set[DeviceConditionCallback]] = {}
@@ -404,8 +390,9 @@ async def active_scan(
             # error message.
             self._check_adapter(adapter_path)
 
-            callback_and_state = CallbackAndState(advertisement_callback, adapter_path)
-            self._advertisement_callbacks.append(callback_and_state)
+            self._advertisement_callbacks.setdefault(adapter_path, []).append(
+                advertisement_callback
+            )
 
             device_removed_callback_and_state = DeviceRemovedCallbackAndState(
                 device_removed_callback, adapter_path
@@ -441,7 +428,9 @@ async def stop() -> None:
                     # need to remove callbacks first, otherwise we get TxPower
                     # and RSSI properties removed during stop which causes
                     # incorrect advertisement data callbacks
-                    self._advertisement_callbacks.remove(callback_and_state)
+                    self._advertisement_callbacks[adapter_path].remove(
+                        advertisement_callback
+                    )
                     self._device_removed_callbacks.remove(
                         device_removed_callback_and_state
                     )
@@ -478,7 +467,9 @@ async def stop() -> None:
                 return stop
             except BaseException:
                 # if starting scanning failed, don't leak the callbacks
-                self._advertisement_callbacks.remove(callback_and_state)
+                self._advertisement_callbacks[adapter_path].remove(
+                    advertisement_callback
+                )
                 self._device_removed_callbacks.remove(device_removed_callback_and_state)
                 raise
 
@@ -512,8 +503,7 @@ async def passive_scan(
             # error message.
             self._check_adapter(adapter_path)
 
-            callback_and_state = CallbackAndState(advertisement_callback, adapter_path)
-            self._advertisement_callbacks.append(callback_and_state)
+            self._advertisement_callbacks[adapter_path].append(advertisement_callback)
 
             device_removed_callback_and_state = DeviceRemovedCallbackAndState(
                 device_removed_callback, adapter_path
@@ -556,7 +546,9 @@ async def stop() -> None:
                     # need to remove callbacks first, otherwise we get TxPower
                     # and RSSI properties removed during stop which causes
                     # incorrect advertisement data callbacks
-                    self._advertisement_callbacks.remove(callback_and_state)
+                    self._advertisement_callbacks[adapter_path].remove(
+                        advertisement_callback
+                    )
                     self._device_removed_callbacks.remove(
                         device_removed_callback_and_state
                     )
@@ -580,7 +572,9 @@ async def stop() -> None:
 
             except BaseException:
                 # if starting scanning failed, don't leak the callbacks
-                self._advertisement_callbacks.remove(callback_and_state)
+                self._advertisement_callbacks[adapter_path].remove(
+                    advertisement_callback
+                )
                 self._device_removed_callbacks.remove(device_removed_callback_and_state)
                 raise
 
@@ -926,7 +920,7 @@ def _parse_msg(self, message: Message) -> None:
                 # devices that only advertise once and then go to sleep for a while.
                 elif interface == defs.DEVICE_INTERFACE:
                     self._run_advertisement_callbacks(
-                        obj_path, cast(Device1, unpacked_props), unpacked_props.keys()
+                        obj_path, cast(Device1, unpacked_props)
                     )
         elif message.member == "InterfacesRemoved":
             obj_path, interfaces = message.body
@@ -1003,7 +997,7 @@ def _parse_msg(self, message: Message) -> None:
                     device_path = message_path
 
                     self._run_advertisement_callbacks(
-                        device_path, cast(Device1, self_interface), changed.keys()
+                        device_path, cast(Device1, self_interface)
                     )
 
                     # handle device condition watchers
@@ -1035,22 +1029,16 @@ def _parse_msg(self, message: Message) -> None:
                                     message_path, new_value
                                 )
 
-    def _run_advertisement_callbacks(
-        self, device_path: str, device: Device1, changed: Iterable[str]
-    ) -> None:
+    def _run_advertisement_callbacks(self, device_path: str, device: Device1) -> None:
         """
         Runs any registered advertisement callbacks.
 
         Args:
             device_path: The D-Bus object path of the remote device.
             device: The current D-Bus properties of the device.
-            changed: A list of properties that have changed since the last call.
         """
-        for callback, adapter_path in self._advertisement_callbacks:
-            # filter messages from other adapters
-            if adapter_path != device["Adapter"]:
-                continue
-
+        adapter_path = device["Adapter"]
+        for callback in self._advertisement_callbacks[adapter_path]:
             callback(device_path, device.copy())