diff --git a/src/sbomnix/cpe.py b/src/sbomnix/cpe.py
index e6b33cf..082640b 100644
--- a/src/sbomnix/cpe.py
+++ b/src/sbomnix/cpe.py
@@ -4,10 +4,12 @@
 
 # pylint: disable=too-few-public-methods
 
-""" Generate CPE (Common Platform Enumeration) identifiers"""
+"""Generate CPE (Common Platform Enumeration) identifiers"""
 
 import sys
 import string
+import time
+from sqlite3 import OperationalError
 from dfdiskcache import DataFrameDiskCache
 from common.utils import (
     LOG,
@@ -43,7 +45,19 @@ def __init__(self):
                     "Failed downloading cpedict: CPE information might not be accurate"
                 )
             else:
-                self.cache.set(_CPE_CSV_URL, self.df_cpedict, ttl=_CPE_CSV_CACHE_TTL)
+                waiting = True
+                while waiting:
+                    try:
+                        self.cache.set(
+                            _CPE_CSV_URL, self.df_cpedict, ttl=_CPE_CSV_CACHE_TTL
+                        )
+                        waiting = False
+                    except OperationalError:
+                        LOG.warning(
+                            "CPE Sqlite database is locked! Retrying in 1 second"
+                        )
+                        time.sleep(1)
+
         if self.df_cpedict is not None:
             # Verify the loaded cpedict contains at least the following columns
             required_cols = {"vendor", "product"}
diff --git a/src/sbomnix/meta.py b/src/sbomnix/meta.py
index 5853adb..3e08a8b 100644
--- a/src/sbomnix/meta.py
+++ b/src/sbomnix/meta.py
@@ -6,10 +6,12 @@
 
 """Cache nixpkgs meta information"""
 
+import time
 import os
 import re
 import logging
 
+from sqlite3 import OperationalError
 import pandas as pd
 from dfdiskcache import DataFrameDiskCache
 from nixmeta.scanner import NixMetaScanner, nixref_to_nixpkgs_path
@@ -33,7 +35,15 @@ class Meta:
     """Cache nixpkgs meta information"""
 
     def __init__(self):
-        self.cache = DataFrameDiskCache(cache_dir_path=DFCACHE_PATH)
+        waiting = True
+        while waiting:
+            try:
+                self.cache = DataFrameDiskCache(cache_dir_path=DFCACHE_PATH)
+                waiting = False
+            except OperationalError:
+                LOG.warning("DFCACHE Sqlite database is locked! Retrying in 1 second")
+                time.sleep(1)
+
         # df_nixmeta includes the meta-info from _NIXMETA_CSV_URL
         self.df_nixmeta = self.cache.get(_NIXMETA_CSV_URL)
         if self.df_nixmeta is not None and not self.df_nixmeta.empty: